Summary: A genus of gram-positive, microaerophilic, rod-shaped bacteria occurring widely in nature. Its species are also part of the many normal flora of the mouth, intestinal tract, and vagina of many mammals, including humans. Pathogenicity from this genus is rare.

Top Publications

  1. pmc Complete genome sequence of Lactobacillus plantarum WCFS1
    Michiel Kleerebezem
    Wageningen Centre for Food Sciences, P O Box 557, 6700 AN Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 100:1990-5. 2003
  2. pmc Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and Methanogens in anorexic patients
    Fabrice Armougom
    URMITE UMR CNRS 6236, IRD 3R198, Universite de la Mediterranee, Faculte de Medecine, and Nutrition and Diabetology Department, University Hospital Sainte Marguerite, Marseille, France
    PLoS ONE 4:e7125. 2009
  3. ncbi Molecular identification of bacteria associated with bacterial vaginosis
    David N Fredricks
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    N Engl J Med 353:1899-911. 2005
  4. pmc Temporal variability of human vaginal bacteria and relationship with bacterial vaginosis
    Sujatha Srinivasan
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 5:e10197. 2010
  5. ncbi Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
    M Kalliomaki
    Department of Paediatrics, University of Turku and Turku University Hospital, Finland
    Lancet 357:1076-9. 2001
  6. ncbi Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin
    Hermelijn H Smits
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Allergy Clin Immunol 115:1260-7. 2005
  7. ncbi The extracellular biology of the lactobacilli
    Michiel Kleerebezem
    TI Food and Nutrition, Wageningen, The Netherlands
    FEMS Microbiol Rev 34:199-230. 2010
  8. pmc Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
    Javier A Bravo
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Proc Natl Acad Sci U S A 108:16050-5. 2011
  9. ncbi Bacteriocins: developing innate immunity for food
    Paul D Cotter
    Alimentary Pharmabiotic Centre, Microbiology Department, University College Cork, Cork, Ireland
    Nat Rev Microbiol 3:777-88. 2005
  10. pmc Deep sequencing of the vaginal microbiota of women with HIV
    Ruben Hummelen
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Canada
    PLoS ONE 5:e12078. 2010

Detail Information

Publications349 found, 100 shown here

  1. pmc Complete genome sequence of Lactobacillus plantarum WCFS1
    Michiel Kleerebezem
    Wageningen Centre for Food Sciences, P O Box 557, 6700 AN Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 100:1990-5. 2003
    The 3,308,274-bp sequence of the chromosome of Lactobacillus plantarum strain WCFS1, a single colony isolate of strain NCIMB8826 that was originally isolated from human saliva, has been determined, and contains 3,052 predicted protein-..
  2. pmc Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and Methanogens in anorexic patients
    Fabrice Armougom
    URMITE UMR CNRS 6236, IRD 3R198, Universite de la Mediterranee, Faculte de Medecine, and Nutrition and Diabetology Department, University Hospital Sainte Marguerite, Marseille, France
    PLoS ONE 4:e7125. 2009
    ..The roles of the archaeon Methanobrevibacter smithii and Lactobacillus species have not been described in these studies.
  3. ncbi Molecular identification of bacteria associated with bacterial vaginosis
    David N Fredricks
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    N Engl J Med 353:1899-911. 2005
    ..The cause of bacterial vaginosis remains poorly understood despite numerous studies based on cultures. Bacteria in microbial communities can be identified without cultivation by characterizing their ribosomal DNA (rDNA) sequences...
  4. pmc Temporal variability of human vaginal bacteria and relationship with bacterial vaginosis
    Sujatha Srinivasan
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 5:e10197. 2010
    ..This study used PCR to assess the variability in concentrations of key vaginal bacteria in healthy women and the immediate response to antibiotic treatment in women with bacterial vaginosis (BV)...
  5. ncbi Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
    M Kalliomaki
    Department of Paediatrics, University of Turku and Turku University Hospital, Finland
    Lancet 357:1076-9. 2001
    ..We assessed the effect on atopic disease of Lactobacillus GG (which is safe at an early age and effective in treatment of allergic inflammation and food allergy).
  6. ncbi Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin
    Hermelijn H Smits
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Allergy Clin Immunol 115:1260-7. 2005
    ..On the basis of pathogenic or tissue-specific priming, dendritic cells (DC) acquire different T cell-instructive signals and drive the differentiation of naive T H cells into either T H 1, T H 2, or regulatory effector T cells...
  7. ncbi The extracellular biology of the lactobacilli
    Michiel Kleerebezem
    TI Food and Nutrition, Wageningen, The Netherlands
    FEMS Microbiol Rev 34:199-230. 2010
    ..Next to their role in fermentation processes, specific strains of Lactobacillus are currently marketed as health-promoting cultures or probiotics...
  8. pmc Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
    Javier A Bravo
    Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Proc Natl Acad Sci U S A 108:16050-5. 2011
    ..However, it is unknown whether lactic acid bacteria such as Lactobacillus rhamnosus could have a direct effect on neurotransmitter receptors in the CNS in normal, healthy animals...
  9. ncbi Bacteriocins: developing innate immunity for food
    Paul D Cotter
    Alimentary Pharmabiotic Centre, Microbiology Department, University College Cork, Cork, Ireland
    Nat Rev Microbiol 3:777-88. 2005
    ..In this sense, bacteriocins can be used to confer a rudimentary form of innate immunity to foodstuffs, helping processors extend their control over the food flora long after manufacture...
  10. pmc Deep sequencing of the vaginal microbiota of women with HIV
    Ruben Hummelen
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Canada
    PLoS ONE 5:e12078. 2010
    ..It is poorly understood which bacterial communities constitute BV or the normal vaginal microbiota among this population and how the microbiota associated with BV responds to antibiotic treatment...
  11. ncbi Genome-scale analyses of health-promoting bacteria: probiogenomics
    Marco Ventura
    Department of Genetics, Anthropology and Evolution, University of Parma, Italy
    Nat Rev Microbiol 7:61-71. 2009
    ..In this Review, we discuss the application of probiogenomics in the elucidation of the molecular basis of probiosis using the well-recognized model probiotic bacteria genera Bifidobacterium and Lactobacillus as examples.
  12. ncbi Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria
    Jerry M Wells
    Host Microbe Interactomics, University of Wageningen, Animal Sciences Department, P O Box 338, 6700 AH, Wageningen, The Netherlands
    Nat Rev Microbiol 6:349-62. 2008
  13. pmc Comparative genomics of the lactic acid bacteria
    K Makarova
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Proc Natl Acad Sci U S A 103:15611-6. 2006
  14. ncbi The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells
    C Caballero-Franco
    Institute of Parasitology, McGill University, Saint Anne de Bellevue, Quebec, Canada
    Am J Physiol Gastrointest Liver Physiol 292:G315-22. 2007
    ..Among the three bacterial groups (Lactobacilli, Bifidobacteria, and Streptococci) contained in VSL#3, the Lactobacillus species were the strongest potentiator of mucin secretion in vitro...
  15. ncbi Effect of Lactobacillus gasseri BNR17 on blood glucose levels and body weight in a mouse model of type 2 diabetes
    S I Yun
    R and D Center, BIONEER Co, Daejeon, South Korea
    J Appl Microbiol 107:1681-6. 2009
    To investigate the effect of Lactobacillus gasseri BNR17 isolated from human breast milk on blood glucose and body weight in type 2 diabetic animals.
  16. ncbi Probiotic table olives: microbial populations adhering on olive surface in fermentation sets inoculated with the probiotic strain Lactobacillus paracasei IMPC2.1 in an industrial plant
    Palmira De Bellis
    Institute of Sciences of Food Production ISPA, National Research Council CNR, Via Amendola, 122 O, 70126 Bari, Italy
    Int J Food Microbiol 140:6-13. 2010
    ..Bella di Cerignola in fermentation sets inoculated with the probiotic strain Lactobacillus paracasei IMPC2.1 in different brining conditions (4% and 8% (w/v) NaCl) at room temperature and 4 degrees C...
  17. ncbi Efficacy of Lactobacillus GG in maintaining remission of ulcerative colitis
    M A Zocco
    Department of Internal Medicine, Catholic University of Rome, Rome, Italy
    Aliment Pharmacol Ther 23:1567-74. 2006
    ..Aminosalicylates are the mainstay of therapy to prevent relapse of quiescent ulcerative colitis. The rationale for using probiotics is based on the evidence implicating intestinal bacteria in the pathogenesis of this disorder...
  18. pmc Quantitative determination by real-time PCR of four vaginal Lactobacillus species, Gardnerella vaginalis and Atopobium vaginae indicates an inverse relationship between L. gasseri and L. iners
    Ellen De Backer
    Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, UGent, Ghent, Belgium
    BMC Microbiol 7:115. 2007
    ..Here we applied existing real-time PCR formats for Lactobacillus crispatus, L. gasseri and Gardnerella vaginalis and developed new formats for Atopobium vaginae, L...
  19. ncbi Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial
    Y Kadooka
    Technology and Research Institute, Snow Brand Milk Products Co Ltd, Kawagoe, Saitama, Japan
    Eur J Clin Nutr 64:636-43. 2010
    ..We evaluated the effects of the probiotic Lactobacillus gasseri SBT2055 (LG2055) on abdominal adiposity, body weight and other body measures in adults with obese ..
  20. pmc Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus
    Samuel K Lai
    Department of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Johns Hopkins University, 3400 N Charles Street, Baltimore, Maryland 21218, USA
    J Virol 83:11196-200. 2009
    ..Here, we report that human cervicovaginal mucus (CVM), obtained from donors with normal lactobacillus-dominated vaginal flora, efficiently traps HIV, causing it to diffuse more than 1,000-fold more slowly than it ..
  21. pmc Quantitative analysis of diverse Lactobacillus species present in advanced dental caries
    Roy Byun
    Institute of Dental Research, Westmead Centre for Oral Health, P O Box 533, Wentworthville, NSW 2145, Australia
    J Clin Microbiol 42:3128-36. 2004
    ..Pooled DNA was amplified by PCR with Lactobacillus genus-specific primers for subsequent cloning, sequencing, and phylogenetic analysis...
  22. ncbi Altered early infant gut microbiota in children developing allergy up to 5 years of age
    Y M Sjögren
    Department of Immunology, The Wenner Gren Institute, Arrhenius Laboratory of Natural Sciences F5, Stockholm University, Stockholm, Sweden
    Clin Exp Allergy 39:518-26. 2009
    ..Previous studies of infant gut microbiota in relation to subsequent allergy development have mostly employed culture-dependent techniques, studied genera of bacteria and the follow-up period was limited to 2 years...
  23. pmc Genes and molecules of lactobacilli supporting probiotic action
    Sarah Lebeer
    Centre of Microbial and Plant Genetics, K U Leuven, Kasteelpark Arenberg 20, 3001 Leuven, Belgium
    Microbiol Mol Biol Rev 72:728-64, Table of Contents. 2008
    ..less attention being focused on the specificities of the bacterial partners, notwithstanding the completion of Lactobacillus genome sequencing projects, and increasing possibilities of genomics-based and dedicated mutant analyses...
  24. pmc pH-, Lactic acid-, and non-lactic acid-dependent activities of probiotic Lactobacilli against Salmonella enterica Serovar Typhimurium
    Domitille Fayol-Messaoudi
    Faculte de Pharmacie, Inserm Unité 510, F 92296 Chatenay Malabry, France
    Appl Environ Microbiol 71:6008-13. 2005
    The mechanism(s) underlying the antibacterial activity of probiotic Lactobacillus strains appears to be multifactorial and includes lowering of the pH and the production of lactic acid and of antibacterial compounds, including ..
  25. ncbi Bacterial teichoic acids reverse predominant IL-12 production induced by certain lactobacillus strains into predominant IL-10 production via TLR2-dependent ERK activation in macrophages
    Rumi Kaji
    Yakult Central Institute for Microbiological Research, Tokyo, Japan
    J Immunol 184:3505-13. 2010
    ..To clarify the mechanism whereby Lactobacillus strains differentially induce production of IL-10 and IL-12, we examined the potential relationship between ..
  26. pmc Prevention of vaginal SHIV transmission in macaques by a live recombinant Lactobacillus
    L A Lagenaur
    Gene Structure and Regulation Section, Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Mucosal Immunol 4:648-57. 2011 women occur through the cervicovaginal mucosa, which is coated by a bacterial biofilm including Lactobacillus. This commensal bacterium has a role in maintaining a healthy mucosa and can be genetically engineered to ..
  27. ncbi Randomized placebo-controlled trial of lactobacillus on asthmatic children with allergic rhinitis
    Yue Sheng Chen
    Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Pediatr Pulmonol 45:1111-20. 2010
    ..To determine whether daily supplementation with specific Lactobacillus gasseri A5 for 8 weeks can improve the clinical symptoms and immunoregulatory changes in school children ..
  28. ncbi Effect of intranasal administration of Lactobacillus pentosus S-PT84 on influenza virus infection in mice
    Takayuki Izumo
    Institute for Health Care Science, Suntory Wellness Limited, 1 1 1 Wakayamadai, Shimamoto cho, Mishima gun, Osaka 618 8503, Japan
    Int Immunopharmacol 10:1101-6. 2010
    b>Lactobacillus pentosus strain S-PT84 isolated from Kyoto pickles enhances splenic natural killer (NK) cell activity and exhibit anti-allergic effects by modulating the Th1/Th2 (T-helper1/T-helper2) balance...
  29. ncbi Lactobacillus sepsis associated with probiotic therapy
    Michael H Land
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Pediatrics 115:178-81. 2005
    ..patients who received probiotic lactobacilli and subsequently developed bacteremia and sepsis attributable to Lactobacillus species...
  30. pmc Pyrosequencing of the genital microbiotas of HIV-seropositive and -seronegative women reveals Lactobacillus iners as the predominant Lactobacillus Species
    Gregory T Spear
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    Appl Environ Microbiol 77:378-81. 2011
    ..b>Lactobacillus iners sequences were the predominant lactobacillus sequences in 66% of HIV(+) women and 90% of HIV(-) women...
  31. ncbi New scientific paradigms for probiotics and prebiotics
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, N6A 4V2, Canada
    J Clin Gastroenterol 37:105-18. 2003
  32. ncbi Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles
    Liam O'Mahony
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Gastroenterology 128:541-51. 2005
    The aim of this study was to compare the response of symptoms and cytokine ratios in irritable bowel syndrome (IBS) with ingestion of probiotic preparations containing a lactobacillus or bifidobacterium strain.
  33. ncbi Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    Diabetes 57:1470-81. 2008
    ..e., metabolic endotoxemia. Therefore, it remained to demonstrate whether changes in gut microbiota control the occurrence of metabolic diseases...
  34. ncbi Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice
    K L Madsen
    Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    Gastroenterology 116:1107-14. 1999
    ..The aim of this study was to determine the role of colonic aerobic luminal bacteria and Lactobacillus species in the development of colitis in interleukin (IL)-10 gene-deficient mice.
  35. ncbi Randomized, double-blind, placebo-controlled trial of probiotics for primary prevention: no clinical effects of Lactobacillus GG supplementation
    Matthias Volkmar Kopp
    University Children s Hospital, Mathildenstrasse 1, D 79106 Freiburg, Germany
    Pediatrics 121:e850-6. 2008
    ..The value of probiotics for primary prevention is controversial. Published trials vary considerably in study design and the applied probiotics, thereby limiting comparability of the results...
  36. ncbi The anti-allergic effects of lactic acid bacteria are strain dependent and mediated by effects on both Th1/Th2 cytokine expression and balance
    Daisuke Fujiwara
    Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, Yokohama, Kanagawa, Japan
    Int Arch Allergy Immunol 135:205-15. 2004
    ..However, no comprehensive studies have been done that compare the immune-stimulating potential of LAB strains...
  37. ncbi A delicate balance: risk factors for acquisition of bacterial vaginosis include sexual activity, absence of hydrogen peroxide-producing lactobacilli, black race, and positive herpes simplex virus type 2 serology
    Thomas L Cherpes
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Sex Transm Dis 35:78-83. 2008
    ..The etiology of bacterial vaginosis (BV) is poorly understood, but better definition of the risk factors associated with its acquisition should improve our understanding of this complex disease entity...
  38. ncbi Taxonomy of Lactobacilli and Bifidobacteria
    Giovanna E Felis
    Dipartimento Scientifico e Tecnologico, Facolta di Scienze MM FF NN, Universita degli Studi di Verona, Strada Le Grazie 15, 37134 Verona, Italy
    Curr Issues Intest Microbiol 8:44-61. 2007
    Genera Lactobacillus and Bifidobacterium include a large number of species and strains exhibiting important properties in an applied context, especially in the area of food and probiotics...
  39. pmc Potential uses of probiotics in clinical practice
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, The Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
    Clin Microbiol Rev 16:658-72. 2003
    ..Based upon the evidence to date, future advances with single- and multiple-strain therapies are on the horizon for the management of a number of debilitating and even fatal conditions...
  40. pmc Differentiation of Lactobacillus plantarum, L. pentosus, and L. paraplantarum by recA gene sequence analysis and multiplex PCR assay with recA gene-derived primers
    S Torriani
    Dipartimento Scientifico e Tecnologico, , , 37134 Verona, Italy
    Appl Environ Microbiol 67:3450-4. 2001
    In this study, we succeeded in differentiating Lactobacillus plantarum, Lactobacillus pentosus, and Lactobacillus paraplantarum by means of recA gene sequence comparison...
  41. ncbi High-level, inducible gene expression in Lactobacillus sakei and Lactobacillus plantarum using versatile expression vectors
    Elisabeth Sørvig
    MATFORSK, Norwegian Food Research Institute, Osloveien 1, N 1430 As, Norway
    Microbiology 151:2439-49. 2005
    Vectors have been developed for inducible gene expression in Lactobacillus sakei and Lactobacillus plantarum in which expression of the gene of interest is driven by strong, regulated promoters from bacteriocin operons found in L...
  42. pmc Longitudinal analysis of the vaginal microflora in pregnancy suggests that L. crispatus promotes the stability of the normal vaginal microflora and that L. gasseri and/or L. iners are more conducive to the occurrence of abnormal vaginal microflora
    Hans Verstraelen
    Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
    BMC Microbiol 9:116. 2009
    ..It remains elusive however to what extent interindividual differences in vaginal Lactobacillus community composition determine the stability of this microflora...
  43. ncbi Factors influencing the composition of the intestinal microbiota in early infancy
    John Penders
    Department of Epidemiology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, Netherlands
    Pediatrics 118:511-21. 2006
    ..The aim of this study was to examine the contribution of a broad range of external influences to the gut microbiotic composition in early infancy...
  44. ncbi Exclusion of vanA, vanB and vanC type glycopeptide resistance in strains of Lactobacillus reuteri and Lactobacillus rhamnosus used as probiotics by polymerase chain reaction and hybridization methods
    G Klein
    Institute of Meat Hygiene and Technology, Veterinary Faculty, Free University of Berlin, Germany
    J Appl Microbiol 89:815-24. 2000
    Strains of Lactobacillus reuteri and Lact. rhamnosus are used as probiotics in man and animal. The aim of this study was to determine whether the glycopeptide resistance in these lactobacilli has a similar genetic basis as in enterococci...
  45. ncbi Rapid PCR-based procedure to identify lactic acid bacteria: application to six common Lactobacillus species
    P Chagnaud
    Département de Microbiologie des Ecosystèmes, Institut Pasteur de Lille 1, rue du Professeur Calmette, BP 245, 59019 Cedex, Lille, France
    J Microbiol Methods 44:139-48. 2001
    ..develop a method allowing rapid identification of the lactic acid bacteria strains in use in the laboratory (Lactobacillus plantarum NCIMB8826; L. fermentum KLD; L. reuteri 100-23; L. salivarius UCC43321; L. paracasei LbTGS1.4; L...
  46. ncbi Protection against translocating Salmonella typhimurium infection in mice by feeding the immuno-enhancing probiotic Lactobacillus rhamnosus strain HN001
    H S Gill
    Milk and Health Research Centre, Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand
    Med Microbiol Immunol 190:97-104. 2001
    The probiotic lactic acid bacterium Lactobacillus rhamnosus (strain HN001) is known to stimulate enhanced innate and acquired immune responses in mice. following oral delivery...
  47. ncbi Protective action of Lactobacillus kefir carrying S-layer protein against Salmonella enterica serovar Enteritidis
    M A Golowczyc
    Centro de Investigación y Desarrollo en Criotecnología de Alimentos CIDCA, Argentina
    Int J Food Microbiol 118:264-73. 2007
    Eight Lactobacillus kefir strains isolated from different kefir grains were tested for their ability to antagonize Salmonella enterica serovar Enteritidis (Salmonella enteritidis) interaction with epithelial cells. L...
  48. ncbi Effects of feeding an infant formula containing Lactobacillus GG on the colonization of the intestine: a dose-response study in healthy infants
    Bryon W Petschow
    Mead Johnson Nutritionals, Evansville, IN 47721, USA
    J Clin Gastroenterol 39:786-90. 2005
    This study aimed to determine whether feeding Lactobacillus GG (LGG) at varying levels (10 to 10 cfu/day) would result in colonization, defined as > or =1,000 cfu of LGG per gram of stool in 3 of 5 samples collected during the feeding ..
  49. ncbi Predominant genera of fecal microbiota in children with atopic dermatitis are not altered by intake of probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07
    Nadja Larsen
    Department of Food Science, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    FEMS Microbiol Ecol 75:482-96. 2011
    The effect of probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 on the composition of the Lactobacillus group, Bifidobacterium and the total bacterial population in feces from young children with atopic ..
  50. ncbi Lactobacillus GG improves recovery in infants with blood in the stools and presumptive allergic colitis compared with extensively hydrolyzed formula alone
    Maria Elisabetta Baldassarre
    Neonatology and Neonatal Intensive Care Unit, Department of Gynecology, Obstetrics and Neonatology, University of Bari Policlinic Hospital, Bari, Italy
    J Pediatr 156:397-401. 2010
    To determine the benefits of Lactobacillus rhamnosus GG (LGG) in an extensively hydrolyzed casein formula (EHCF) in improving hematochezia and fecal calprotectin over EHCF alone.
  51. ncbi Effect of orthodontic treatment on saliva, plaque and the levels of Streptococcus mutans and Lactobacillus
    Edith Lara-Carrillo
    Department of Orthodontics, Research Center, School of Dentistry, Universidad Autonoma del Estado de Mexico, Toluca, Estado de Mexico, Mexico
    Med Oral Patol Oral Cir Bucal 15:e924-9. 2010
    ..The aim of this study was to identify changes in the oral environment with clinical, salivary and bacterial risk markers after placement of fixed orthodontic appliances on permanent dentition...
  52. pmc Immunobiotic Lactobacillus jensenii elicits anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the Toll-like receptor signaling pathway
    Tomoyuki Shimazu
    Food Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Infect Immun 80:276-88. 2012
    The effect of Lactobacillus jensenii TL2937 on the inflammatory immune response triggered by enterotoxigenic Escherichia coli (ETEC) and lipopolysaccharide (LPS) in a porcine intestinal epitheliocyte cell line (PIE cells) was evaluated...
  53. pmc Lactobacillus adhesion to mucus
    Maxwell L Van Tassell
    Department of Food Science and Human Nutrition, University of Illinois, 905 S Goodwin Ave, Urbana, IL 61801, USA
    Nutrients 3:613-36. 2011
    ..polymerize, forming a framework to which certain microbial populations can adhere, including probiotic Lactobacillus species...
  54. ncbi Treatment of green table olive solutions with ozone. Effect on their polyphenol content and on Lactobacillus pentosus and Saccharomyces cerevisiae growth
    K A Segovia Bravo
    Food Biotechnology Department, Instituto de la Grasa CSIC, Avda Padre Garcia Tejero, 4 41012, Seville, Spain
    Int J Food Microbiol 114:60-8. 2007
    ..In this study we evaluated the effect of ozone treated GTOS on the growth of Saccharomyces cerevisiae and Lactobacillus pentosus. GTOS were treated with ozone for 24 and 72 h...
  55. ncbi Effects of ingesting Lactobacillus- and Bifidobacterium-containing yogurt in subjects with colonized Helicobacter pylori
    Kuan Yuan Wang
    Department of Internal Medicine, Kaohsiung Municipal United Hospital, Kaohsiung, Taiwan, Republic of China
    Am J Clin Nutr 80:737-41. 2004
    ..Supplementing with Lactobacillus- and Bifidobacterium-containing yogurt (AB-yogurt) was shown to improve the rates of eradication of H...
  56. ncbi Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial
    Marko Kalliomaki
    Department of Paediatrics, University of Turku, Finland
    Lancet 361:1869-71. 2003
    Perinatal administration of the probiotic Lactobacillus rhamnosus strain GG (ATCC 53103), reduces incidence of atopic eczema in at-risk children during the first 2 years of life (infancy)...
  57. pmc Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial
    K Hatakka
    Valio Research and Development, PO Box 30, FIN-00039 Valio, Helsinki, Finland
    BMJ 322:1327. 2001
    ..4 (1.5) years) in the control group. Intervention: Milk with or without Lactobacillus GG. Average daily consumption of milk in both groups was 260 ml...
  58. pmc Histamine-producing pathway encoded on an unstable plasmid in Lactobacillus hilgardii 0006
    Patrick M Lucas
    Faculté d Oenologie, UMR 1219, INRA Université Victor Segalen Bordeaux 2, 351, Cours de la Liberation, 33405 Talence, France
    Appl Environ Microbiol 71:1417-24. 2005
    ..We have isolated a histamine-producing lactic acid bacterium, Lactobacillus hilgardii strain IOEB 0006, which could retain or lose the ability to produce histamine depending on culture ..
  59. pmc Comparison of the diversity of the vaginal microbiota in HIV-infected and HIV-uninfected women with or without bacterial vaginosis
    Gregory T Spear
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, Illinois, USA
    J Infect Dis 198:1131-40. 2008
    ..Whether human immunodeficiency virus (HIV) infection is associated with a change in the diversity of genital microbiota in women was investigated...
  60. ncbi PCR-based identification of eight Lactobacillus species and 18 hr-HPV genotypes in fixed cervical samples of South African women at risk of HIV and BV
    Joke A M Dols
    Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Diagn Cytopathol 40:472-7. 2012
    ..An inventory of lactobacilli organisms was performed using microarray technology. On the basis of the Lactobacillus and Lactobacillus biofilm scoring, the cases were identified as Leiden bacterial vaginosis (BV) negative (BV-; ..
  61. ncbi Lactic acid bacteria and their effect on the immune system
    G Perdigon
    Centro de Referencias para Lactobacilos CERELA, Chacabuco 145, 4000 Tucuman, Argentina, Instituto de Microbiologia, Facultad de Bioquimica, Quimica y Farmacia, Universidad Nacional de Tucuman, Argentina
    Curr Issues Intest Microbiol 2:27-42. 2001
    ..The basic knowledge of LAB immunostimulation and the criteria for selection of LAB by their immunostimulatory capacity, will be extensively discussed and appraised in this review...
  62. pmc Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitro
    D R Mack
    Department of Pediatrics, University of Ottawa, Canada
    Gut 52:827-33. 2003
    ..Increased MUC3 mRNA transcription is induced by incubation of intestinal epithelial cells with a Lactobacillus strain known to be adherent to them.
  63. ncbi Impact of supplement with Lactobacillus- and Bifidobacterium-containing yogurt on triple therapy for Helicobacter pylori eradication
    B S Sheu
    Department of Internal Medicine, Medical College, National Cheng Kung University, Tainan, Taiwan
    Aliment Pharmacol Ther 16:1669-75. 2002
    To test whether supplements of Lactobacillus- and Bifidobacterium-containing yogurt (AB-Yogurt) affect the success of Helicobacter pylori eradication.
  64. pmc Cell surface-associated lipoteichoic acid acts as an adhesion factor for attachment of Lactobacillus johnsonii La1 to human enterocyte-like Caco-2 cells
    D Granato
    Nestle Research Center, CH 1000 Lausanne 26, Switzerland
    Appl Environ Microbiol 65:1071-7. 1999
    The influence of pH on the adhesion of two Lactobacillus strains to Caco-2 human intestinal cells was investigated. One strain, Lactobacillus johnsonii La1, was adherent at any pH between 4 and 7. The other one, L...
  65. ncbi Synergy between Lactobacillus paracasei and its bacterial products to counteract stress-induced gut permeability and sensitivity increase in rats
    Helene Eutamene
    Neuro Gastroenterology and Nutrition Unit, UMR 1054 INRA EI Purpan, Toulouse, France
    J Nutr 137:1901-7. 2007
    Stressful events result in the alteration of gut permeability and sensitivity. Lactobacillus paracasei NCC2461 (Lpa) therapy prevents antibiotic-induced visceral hyperalgesia in mice...
  66. ncbi Effects of Lactobacillus gasseri BNR17 on body weight and adipose tissue mass in diet-induced overweight rats
    Ji Hee Kang
    R and D Center, BIONEER Co, Daejeon 306 220, Republic of Korea
    J Microbiol 48:712-4. 2010
    We investigated the weight-gain suppressive effect of Lactobacillus gasseri BNR17 isolated from human breast milk. Rats were fed a high-carbohydrate diet and administered BNR17 (BNR17 group) twice daily for twelve weeks...
  67. ncbi Effect of probiotic Lactobacillus strains in children with atopic dermatitis
    Vibeke Rosenfeldt
    Research Department of Human Nutrition and the LMC Center for Advanced Food Studies, The Royal Veterinary and Agricultural University, Copenhagen, Denmark
    J Allergy Clin Immunol 111:389-95. 2003
    ..Recent studies suggest that oral bacteriotherapy with probiotics might be useful in the management of atopic dermatitis (AD)...
  68. pmc Comparative and functional analysis of sortase-dependent proteins in the predicted secretome of Lactobacillus salivarius UCC118
    Jan Peter van Pijkeren
    Department of Microbiology, University College Cork, Cork, Ireland
    Appl Environ Microbiol 72:4143-53. 2006
    ..We performed a comparative bioinformatic analysis of four publicly available Lactobacillus genomes and the genome of Lactobacillus salivarius subsp...
  69. ncbi Quantification of Bifidobacterium spp. and Lactobacillus spp. in rat fecal samples by real-time PCR
    Jean Marc Delroisse
    FUSAGx, Unité de Biologie Animale et Microbienne, avenue Maréchal Juin, 6, 5030 Gembloux, Belgium
    Microbiol Res 163:663-70. 2008
    ..Real-time PCR detection of serially diluted DNA isolated from reference strains of Bifidobacterium longum and Lactobacillus acidophilus was linear for cell counts ranging from 10(6) to 10 cells per PCR assay...
  70. pmc Lactobacillus GG as an immune adjuvant for live-attenuated influenza vaccine in healthy adults: a randomized double-blind placebo-controlled trial
    L E Davidson
    Division of Geographic Medicine and Infectious Diseases, Department of Medicine, Tufts Medical Center, Boston, MA 02111, USA
    Eur J Clin Nutr 65:501-7. 2011
    ..We hypothesized that Lactobacillus GG (LGG) would function as an immune adjuvant to increase rates of seroconversion after LAIV administration.
  71. ncbi The Lactobacillus and Bifidobacterium microflora of the human intestine: composition and succession
    G Reuter
    Department of Food Hygiene, Veterinary Faculty, Free University of Berlin, Bruemmerstr. 10, D-14195 Berlin, Dahlem, Germany
    Curr Issues Intest Microbiol 2:43-53. 2001
    b>Lactobacillus and bifidobacterial cultures are increasingly used as probiotics in pharmaceuticals and in foods. The selection of strains is performed often for technological rather than for microecological reasons...
  72. ncbi Lactobacillus kefiranofaciens M1 isolated from milk kefir grains ameliorates experimental colitis in vitro and in vivo
    Y P Chen
    Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan, ROC
    J Dairy Sci 95:63-74. 2012
    b>Lactobacillus kefiranofaciens M1, isolated from and identified in Taiwanese milk kefir grain, has demonstrated immune-modulating activity. In the present study, we further investigated the effects of Lb...
  73. ncbi Species diversity and relative abundance of vaginal lactic acid bacteria from women in Uganda and Korea
    L Jin
    Department of Oral Biology, University of Illinois, Chicago, IL 60612, USA
    J Appl Microbiol 102:1107-15. 2007
    ..The aim of this study was to compare the species richness and relative abundance of Lactobacillus and other lactic acid bacteria in women of two geographically distant countries, Uganda and Korea.
  74. ncbi Extracellular proteins of Lactobacillus crispatus enhance activation of human plasminogen
    Veera Hurmalainen
    General Microbiology, Faculty of Biosciences, PO Box 56, FIN00014 University of Helsinki, Finland
    Microbiology 153:1112-22. 2007
    ..This paper reports that a commensal bacterium, Lactobacillus crispatus, interacts with the Plg system. Strain ST1 of L...
  75. ncbi The novel porcine Lactobacillus sobrius strain protects intestinal cells from enterotoxigenic Escherichia coli K88 infection and prevents membrane barrier damage
    Marianna Roselli
    Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione, 00178 Rome, Italy
    J Nutr 137:2709-16. 2007
    ..porcine intestinal IPEC-1 epithelial cells as a model to investigate a possible protective activity of a new Lactobacillus species, the L...
  76. ncbi Environmental stress responses in Lactobacillus: a review
    Maria de Angelis
    Istituto di Scienze delle Produzioni Alimentari, CNR, Bari, Italy
    Proteomics 4:106-22. 2004
    Environmental stress responses in Lactobacillus, which have been investigated mainly by proteomics approaches, are reviewed...
  77. ncbi Early enteral supply of fiber and Lactobacilli versus conventional nutrition: a controlled trial in patients with major abdominal surgery
    Nada Rayes
    Department of Surgery, Charite, Campus Virchow, Augustenberger Platz 1, 13355 Berlin, Germany
    Nutrition 18:609-15. 2002
    Early enteral nutrition with fiber-containing solutions plus Lactobacillus may reduce bacterial translocation and minimize the incidence of infections after surgery.
  78. ncbi Characterization and heterologous expression of a class IIa bacteriocin, plantaricin 423 from Lactobacillus plantarum 423, in Saccharomyces cerevisiae
    C A Van Reenen
    Department of Microbiology, University of Stellenbosch, J C Smuts Building, Block A De Beer Avenue, 7600, Stellenbosch, South Africa
    Int J Food Microbiol 81:29-40. 2003
    b>Lactobacillus plantarum 423 produces a small heat-stable antimicrobial protein designated plantaricin 423. This protein is bactericidal for many Gram-positive foodborne pathogens and spoilage bacteria, including Listeria spp...
  79. ncbi Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses
    Y M Sjögren
    Department of Immunology, Wenner Gren Institute, Stockholm University, Stockholm, Sweden
    Clin Exp Allergy 39:1842-51. 2009
    ..Although animal and in vitro studies emphasize the role of the commensal gut microbiota in the development of the immune system, the influence of the gut microbiota on immune development in infants is unclear...
  80. ncbi Lactobacillus rhamnosus alleviates intestinal barrier dysfunction in part by increasing expression of zonula occludens-1 and myosin light-chain kinase in vivo
    E Miyauchi
    Graduate School of Biosphere Science, Hiroshima University, 1 4 4 Kagamiyama, Higashi Hiroshima, Hiroshima 739 8528, Japan
    J Dairy Sci 92:2400-8. 2009
    ..Among the 4 lactobacilli studied, Lactobacillus rhamnosus OLL2838 most effectively suppressed barrier impairment and increased IL-8 secretion induced by tumor ..
  81. ncbi Genome shuffling of Lactobacillus for improved acid tolerance
    Ranjan Patnaik
    Codexis, 515 Galveston Drive, Redwood City, CA 94063, USA
    Nat Biotechnol 20:707-12. 2002
    ..the use of genome shuffling to improve the acid tolerance of a poorly characterized industrial strain of Lactobacillus. We used classical strain-improvement methods to generate populations with subtle improvements in pH tolerance,..
  82. ncbi Lactobacillus phylogenomics--towards a reclassification of the genus
    Marcus J Claesson
    Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Int J Syst Evol Microbiol 58:2945-54. 2008
    The extremely diverse genus Lactobacillus is the largest among the lactic acid bacteria, with over 145 recognized species...
  83. pmc Ineffectiveness of Lactobacillus johnsonii LA1 for prophylaxis of postoperative recurrence in Crohn's disease: a randomised, double blind, placebo controlled GETAID trial
    P Marteau
    Department Gastroenterology, Hopital Europeen Georges Pompidou, Paris, France
    Gut 55:842-7. 2006
    ..Bacteria are involved, and probiotics may modulate immune responses to the intestinal flora. Here we tested the probiotic strain Lactobacillus johnsonii LA1 in this setting.
  84. pmc Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: a randomised controlled trial with Lactobacillus GG
    C Prantera
    Division of Gastroenterology, Azienda Ospedaliera S Camillo Forlanini, Rome, Italy
    Gut 51:405-9. 2002
    ..The aim of this randomised placebo controlled study was to determine if Lactobacillus GG, given by mouth for one year, could prevent Crohn's recurrent lesions after surgery or to reduce their ..
  85. ncbi Probiotics: an overview of beneficial effects
    Arthur C Ouwehand
    Department of Biochemistry and Food Chemistry, University of Turku, FIN 20014 Turku, Finland
    Antonie Van Leeuwenhoek 82:279-89. 2002
    ..Results from well conducted clinical studies will expand and increase the acceptance of probiotics for the treatment and prevention of selected diseases...
  86. ncbi Lactobacillus reuteri (DSM 17938) in infants with functional chronic constipation: a double-blind, randomized, placebo-controlled study
    Paola Coccorullo
    Department of Pediatrics, University of Naples Federico II, Naples, Italy
    J Pediatr 157:598-602. 2010
    To evaluate the beneficial effects of Lactobacillus reuteri (DSM 17938) in infants with functional chronic constipation.
  87. ncbi Lactic acid bacteria colonization and clinical outcome after probiotic supplementation in conventionally treated bacterial vaginosis and vulvovaginal candidiasis
    Sophia Ehrstrom
    Karolinska Institutet, Department of Clinical Sciences, Division of Obstetrics and Gynecology, Danderyd Hospital, Stockholm, PA 182 88, Sweden
    Microbes Infect 12:691-9. 2010
    ..Vaginal capsules containing L gasseri LN40, Lactobacillus fermentum LN99, L. casei subsp. rhamnosus LN113 and P...
  88. ncbi The S-layer proteins of Lactobacillus crispatus strain ZJ001 is responsible for competitive exclusion against Escherichia coli O157:H7 and Salmonella typhimurium
    Xueyan Chen
    Zhejiang University Institute of Preventive Veterinary Medicine, and Zhejiang Provincial Key Laboratory of Prevent Veterinary Medicine, Hangzhou, PR China
    Int J Food Microbiol 115:307-12. 2007
    b>Lactobacillus crispatus ZJ001, isolated from pig intestines and identified by sequencing analysis based on partial 16S rRNA gene, was examined in vitro for probiotic activity exerted by the surface layer proteins (S-layer)...
  89. pmc Lactobacillus GG in inducing and maintaining remission of Crohn's disease
    Michael Schultz
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    BMC Gastroenterol 4:5. 2004
    ..The aim of this randomized, placebo-controlled trial was to determine the effect of oral Lactobacillus GG (L. GG) to induce or maintain medically induced remission.
  90. ncbi Multicenter randomized-controlled clinical trial of probiotics (Lactobacillus johnsonii, LA1) on early endoscopic recurrence of Crohn's disease after lleo-caecal resection
    Andre Van Gossum
    Erasme University Hospital, ULB, Brussels, Belgium
    Inflamm Bowel Dis 13:135-42. 2007
    ..This study is a multicenter clinical trial evaluating the efficacy of an oral administration of the probiotic LAl on early post-operative endoscopic recurrence of CD...
  91. ncbi Antimicrobial activity of lactic acid bacteria isolated from sour doughs: purification and characterization of bavaricin A, a bacteriocin produced by Lactobacillus bavaricus MI401
    A G Larsen
    Department of Dairy and Food Science, Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Appl Bacteriol 75:113-22. 1993
    ..These 18 isolates belonged to three different Lactobacillus species: Lactobacillus bavaricus, Lactobacillus curvatus and Lactobacillus plantarum...
  92. pmc Lactobacillus johnsonii La1 antagonizes Giardia intestinalis in vivo
    Martín A Humen
    CIDCA, Universidad Nacional de La Plata, Calle 47 y 116 CC 553, 1900 La Plata, Argentina
    Infect Immun 73:1265-9. 2005
    This study describes the in vivo activity of Lactobacillus johnsonii La1 (NCC533) in Giardia intestinalis-infected gerbils (Meriones unguiculatus)...
  93. pmc Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization
    Mansour Mohamadzadeh
    National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 102:2880-5. 2005
    ..Many Lactobacillus species are normal members of the human gut microflora and most are regarded as safe when administered as ..
  94. ncbi Lactobacillus acidipiscis sp. nov. and Weissella thailandensis sp. nov., isolated from fermented fish in Thailand
    S Tanasupawat
    Department of Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    Int J Syst Evol Microbiol 50:1479-85. 2000
    ..They were identified as new species and named Lactobacillus acidipiscis sp. nov. and Weissella thailandensis sp. nov...
  95. pmc Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria
    Benoit Foligne
    Bactéries Lactiques and Immunité des Muqueuses, Institut Pasteur de Lille, 1 rue du Professeur Calmette, Lille cedex F 59019, France
    World J Gastroenterol 13:236-43. 2007
    ..To investigate the correlation between in vitro and in vivo immunomodulation potential of the probiotic strain and its ability to prevent experimental colitis in mice...
  96. ncbi Overview of gut flora and probiotics
    W H Holzapfel
    Institute of Hygiene and Toxicology, Federal Research Centre for Nutrition, Karlsruhe, Germany
    Int J Food Microbiol 41:85-101. 1998
  97. ncbi Survival of freeze-dried Lactobacillus bulgaricus KFRI 673 in chitosan-coated calcium alginate microparticles
    J S Lee
    Graduate School of Biotechnology, Korea University, 1, 5 Ka, Anam Dong, Sungbuk Ku, Seoul 136 701, Korea
    J Agric Food Chem 52:7300-5. 2004
    ..alginate microparticles coated with three kinds of chitosans of different molecular weights on the survival of Lactobacillus bulgaricus KFRI 673 in simulated gastric (SGJ) and intestinal juices (SIJ) and on their stability during ..
  98. ncbi Lactobacillus strains differentially modulate cytokine production by hPBMC from pollen-allergic patients
    Yvonne M Vissers
    Cell Biology and Immunology Group, Wageningen University and Research Centre, Wageningen, The Netherlands
    FEMS Immunol Med Microbiol 61:28-40. 2011
    The objective of this study was to assess the potential immunomodulatory effect of six Lactobacillus strains on human peripheral blood mononuclear cells (hPBMC) isolated from allergic patients...
  99. pmc Improved stress tolerance of GroESL-overproducing Lactococcus lactis and probiotic Lactobacillus paracasei NFBC 338
    C Desmond
    Teagasc, Biotechnology Centre, Moorepark, Fermoy, County Cork, Ireland
    Appl Environ Microbiol 70:5929-36. 2004
    ..Two-dimensional polyacrylamide gel electrophoresis revealed that GroEL expression in probiotic Lactobacillus paracasei NFBC 338 was increased under heat adaptation conditions (52 degrees C for 15 min)...
  100. ncbi Monostrain, multistrain and multispecies probiotics--A comparison of functionality and efficacy
    H M Timmerman
    Department of Nutrition, Faculty of Veterinary Medicine, Utrecht University, P O Box 80 152, 3508 TD Utrecht, The Netherlands
    Int J Food Microbiol 96:219-33. 2004
    ..It is also emphasized that strains used in multistrain and multispecies probiotics should be compatible or, preferably, synergistic. The design and use of multistrain and multispecies probiotics should be encouraged...
  101. pmc Mixed-culture transcriptome analysis reveals the molecular basis of mixed-culture growth in Streptococcus thermophilus and Lactobacillus bulgaricus
    Sander Sieuwerts
    Top Institute Food and Nutrition, P O Box 557, 6700 AN Wageningen, Netherlands
    Appl Environ Microbiol 76:7775-84. 2010
    ..Yogurt fermentation by Streptococcus thermophilus and Lactobacillus bulgaricus (basonym, Lactobacillus delbrueckii subsp...

Research Grants74

  1. Natural antimicrobials against bacterial vaginosis
    Michael Chikindas; Fiscal Year: 2006
    ..Healthy vaginal Lactobacillus rhamnosus strain 160 produces an antimicrobial peptide, bacteriocin, designated as lactocin 160, which is ..
  2. Effect of Lactobacillus GG on gut permeability and microbiome in VLBW neonates
    ROSE MARIE VISCARDI; Fiscal Year: 2013
    ..Our long-term goal is to determine the safety and efficacy of Lactobacillus rhamnosus GG (LGG) to prevent NEC in VLBW infants...
  3. Diet and Gastrointestinal Cancer Risk in African Americans and Rural Africans
    STEPHEN JD O'KEEFE; Fiscal Year: 2012
    ..In contrast, a high resistant starch diet stimulates mucosal-protective Lactobacillus species were, indeed, found to be more common in Africans...
  4. Mucosal Immunity and Microbiota in Intestinal Graft-versus-Host Disease
    Marcel R m van den Brink; Fiscal Year: 2013
    ..flora, including a loss of microbial diversity, dysbiosis (imbalance of intestinal flora) and the expansion of Lactobacillus or Enterobacteriaceae, which have opposite effects on GVHD...
  5. Probiotic-Induced Elimination of Oxalate to treat Hyperoxaluria
    Marguerite Hatch; Fiscal Year: 2013
    ..Other bacteria including Lactobacillus sp. and Bifidobacterium sp...
  6. Development of transformed lactobacilli as a microbicide
    Richard B Markham; Fiscal Year: 2010
    ..b>Lactobacillus rhamnosus GR-1 will be used in a mouse model that does not require progesterone pre-treatment, as this strain ..
  7. Probiotics and HIF signaling in Alcoholic Liver Disease
    Wenke Feng; Fiscal Year: 2013
    ..Supplementation of a probiotic strain, lactobacillus rhamnosus GG (LGG), attenuates those deleterious effects and ALD. However, the mechanisms are unknown...
  8. (PQA1) Mechanism of Vitamin D Chemoprevention Against Colon Cancer
    Yan Chun Li; Fiscal Year: 2013
    ..We will compare tumorigenesis in gnotobiotic mice mono-associated with Lactobacillus acidophilus lacking 7-DH to mice also associated with Clostridium scindens expressing 7-DH fed Western diet or ..
  9. Development of Site-Specific Mutagenesis in Coxiella burnetti
    JAMES EVANS SAMUEL; Fiscal Year: 2012
    ..burnetii using allelic exchange or the retrohoming mechanism of the mobile group II intron LtrB of Lactobacillus lactis (TargeTron technology, Sigma-Aldrich)...
  10. Gut microflora: Impact on neonatal immunity, viral gastroenteritis and vaccines
    ..Neonates undergo progressive changes in the gut microflora which we will model by colonizing Gn pigs with Lactobacillus spp (Gram, G+), E. coli (G- ), both, or a commensal cocktail from conventional piglets...
  11. New composite material design based on studies of tooth-composite and microbial i
    J Paul Santerre; Fiscal Year: 2013
    ..Post degradation specimens will be exposed to S. mutans UA159 alone or with Lactobacillus casei ATCC 746 in a chemostat based biofilms fermentor (CBBF), mimicking oral conditions for 7 days...
  12. Lactogenic immunity/probiotics: Effect on neonatal gut immunity
    Linda J Saif; Fiscal Year: 2010
    ..Bifidobacteria and lactobacillus strains differ in breastfed vs formula fed infants...
  13. Probiotics-derived soluble proteins regulate intestinal inflammation
    Fang Yan; Fiscal Year: 2013
    Project Summary/Abstract Lactobacillus rhamnosus GG (LGG) is one of the best-studied probiotic bacteria in clinical trials for treating and/or preventing several intestinal disorders, includig inflammatory bowel disease (IBD)...
  14. Phenotype MicroArray Analysis of Fastidious Pathogens
    Barry Bochner; Fiscal Year: 2009
    ..Arcobacter, Wolinella), and important colonizers of the colon and vagina (Bacteroides, Clostridium, Lactobacillus, Escherichia)...
  15. Enhancement of NAFLD risk by vinyl chloride: interaction of gut-liver-adipose axi
    JULIANE INGEBORG BEIER; Fiscal Year: 2013
    ..signaling cascades, impairs barrier function integrity in NAFLD and that probiotic supplementation [Lactobacillus rhamnosus Gorbach-Goldin (LGG)] will attenuate these effects. Aim 1...
  16. Probiotics and Innate Intestinal Defense
    ..Our long term goal is to explain how the probiotic commensal bacterium Lactobacillus rhamnosus (LGG) might act to prevent NEC in newborn humans...
  17. Mechanisms of Immune Modulation by Probiotics
    Lijuan Yuan; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Some probiotic Lactobacillus strains demonstrated intrinsic adjuvanticity and enhanced antigen-specific immune responses to rotavirus infection and to viral and bacterial vaccines...
    David A Haake; Fiscal Year: 2013
    ..coli and Lactobacillus oral OMP-based vaccines that prevent acquisition of renal infection by reservoir hosts and effectively block ..
  19. Immature intestinal NF-kB regulation, probiotics, and necrotizing enterocolitis
    Erika C Claud; Fiscal Year: 2013
    ..2. Determine the ability of secreted bacterial products from the probiotic organisms Lactobacillus plantarum, Lactobacillus acidophilus, and Bifidobacterium infantis to protect against necrotizing ..
  20. Gut micro biota in patients with multiple sclerosis
    Howard L Weiner; Fiscal Year: 2012
    ..In the EAE mouse model of MS, probiotic administration of lactobacillus reduces disease activity and depletion of microflora using antibiotics in inbred SJL and C57BL/6 mice impaired ..
  21. Identification of Lactobacillus Secreted Factors in Regulation of Pgp
    Seema Saksena; Fiscal Year: 2013
    ..In this regard, we have recently shown that probiotic, Lactobacillus acidophilus (24 h) culture supernatant (CS) increased Pgp function and expression in human intestinal ..
  22. Role of stress-induced reduction in Lactobacillus reuteri on colonic inflammation
    Michael T Bailey; Fiscal Year: 2013
    ..and widely used social stressor, called social disruption (SDR) reduces the abundance of commensal Lactobacillus reuteri in the colon...
  23. VSL for Asthma
    Alessio Fasano; Fiscal Year: 2010
    ..Probiotics (those microbes that produce only beneficial effects in the host gut), such as Lactobacillus and Bifidobacterium are reduced in the intestinal microbiota of atopic individuals and westernized populations...
  24. Mechanistic basis of probiotic prevention of osteoporosis
    Narayanan Parameswaran; Fiscal Year: 2013
    ..Most importantly, oral administration of a human derived probiotic, Lactobacillus reuteri ATCC PTA 6475, inhibits ovx induced intestinal changes, bone marrow T-cell changes and prevents bone ..
  25. Female Genital Innate Immune Response to Vaginal Microbiota
    Caroline M Mitchell; Fiscal Year: 2013
    ..are more vulnerable to colonization due to low baseline levels of those antimicrobial peptides;3) that Lactobacillus species and BV-associated pathogens activate the innate immune response differently via pattern-recognition ..
  26. Vaginal Ring for Preventing Bacterial Vaginosis
    THOMAS RAY MOENCH; Fiscal Year: 2010
    ..provided by applicant): Bacterial Vaginosis (BV) is an exceptionally common vaginal condition in which robust lactobacillus microflora in the vagina is replaced by a dense polymicrobial overgrowth...
  27. Delivery of passive immunity against HIV using commensal vaginal Lactobacillus bi
    Laurel A Lagenaur; Fiscal Year: 2012
    ..In healthy women of childbearing age, mucosal antibodies and microflora, including Lactobacillus jensenii, help protect these surfaces and serve to block the colonization and infection by intruding pathogens...
  28. Development of a Live Combinational Microbicide for Women
    Qiang Xu; Fiscal Year: 2010
    ..The company's lead product, LACTIN-V, is a naturally occurring human vaginal isolate of Lactobacillus crispatus presently undergoing phase II clinical trials to examine its safety and efficacy in preventing ..
  29. Effect of Lactobacillus on genital HIV-1 RNA and DNA shedding in women
    Jane E Hitti; Fiscal Year: 2010
    ..We hypothesize that hydrogen peroxide-producing Lactobacillus (L. crispatus and L...
  30. Lactobacilli as a source of natural microbicides against HIV-1
    RUTH INGRID CONNOR; Fiscal Year: 2011
    ..b>Lactobacillus species are the predominant commensal bacteria found in genital tract secretions of healthy women...
  31. IMpact of PRObiotics for reducing infections in VEterans: The IMPROVE Study
    Nasia Safdar; Fiscal Year: 2013
    ..Middleton Memorial Veterans Hospital, Madison, WI will evaluate the use of a biotherapeutic agent, Lactobacillus rhamnosus HN001, to reduce colonization by antimicrobial-resistant bacteria and thereby prevent serious ..
  32. Safety and Effect of L. reuteri on Biomarkers of Inflammation in Healthy Infants
    Jon Marc Rhoads; Fiscal Year: 2013
    ..Thus, our Primary Aim is to demonstrate (in a two-year trial) if Lactobacillus reuteri is safe in healthy newborns with colic (n=45), at 3 different doses: 5 x 106, 5 x 107, and 5 x 108 c.f...
  33. Probiotic Yogurt for the Treatment of Minimal Hepatic Encephalopathy
    Jasmohan S Bajaj; Fiscal Year: 2011
    ..This proposal intends to define Lactobacillus GG (LGG) as a biologically-based alternative therapy for MHE with special focus on metabolic and stool ..
  34. Vitamin D and the prevalence, incidence, and persistence of bacterial vaginosis
    Abigail Norris Turner; Fiscal Year: 2012 applicant): Bacterial vaginosis (BV) is a vaginal condition that develops when the concentration of healthy Lactobacillus species in the vagina declines and is replaced by other (largely anaerobic) bacterial species...
  35. Novel multivalent vaccine for anthrax and botulinum
    Mansour Mohamadzadeh; Fiscal Year: 2013
    ..A new generation of mucosal vaccines is being developed using probiotic Lactobacillus (L.) strains expressing anthrax-protective antigen (PA) fusion protein...
  36. Microbiome as Therapeutic Target in Alcoholic Hepatitis
    BERND G SCHNABL; Fiscal Year: 2013
    ..qualitative changes are characterized by a profound suppression of commensal probiotic bacteria including Lactobacillus. Pathway analysis revealed that genes involved in fatty acid biosynthesis are underrepresented in the ..
  37. Estrogenic Modulation of Genitourinary Epithelial-Probiotic Cross-Talk
    MICHAEL HARRISON HSIEH; Fiscal Year: 2013
    ..However, commensal Lactobacillus biofilms may prime genitourinary epithelial cells for anti-pathogenic responses by regulating genes which ..
    Diane R Gold; Fiscal Year: 2013
    ..of maternal vitamin D during pregnancy will increase numbers of total and specific anaerobes (B fragilis, and Lactobacillus) in the maternal and child intestinal flora;(2) Increased numbers of anaerobes in the maternal intestinal ..
  39. Development of Bacterial Therapeutics Targeting Bacterial Vaginosis-Associated Bi
    Qiang Xu; Fiscal Year: 2010
    ..vaginosis (BV)-associated biofilm for the prevention and treatment of recurrent BV using a novel strain of Lactobacillus jensenii with a disrupted pox1 gene in the chromosome that exhibits highly potent activity against a ..
  40. Relationship between vaginal micobiota and T. vaginalis acquisition
    OLAMIDE DAPHNA JARRETT; Fiscal Year: 2013
    ..vaginalis and vaginal flora by evaluating: 1) the change in total vaginal Lactobacillus spp concentration and total vaginal bacterial load after T...
  41. Probiotics to Improve Outcomes of Clostridium difficile
    Nasia Safdar; Fiscal Year: 2013 the University of Wisconsin Hospital and Clinics Madison, WI to evaluate the use of a biotherapeutic agent, Lactobacillus rhamnosus HN001, as an adjunct to antibiotic treatment to reduce the duration of diarrhea in hospitalized ..
  42. Mechanisms by which Human Milk Oligosaccharides Protect Against Rotavirus
    SHARON MARIE DONOVAN; Fiscal Year: 2012
    ..Second, we hypothesize that HMO will promote the growth of Lactobacillus and Bifidobacterium, leading to fermentation of oligosaccharides and enhanced mucosal resistance to RV ..
  43. Nature inspired treatments for persistent C. difficile infections
    Julian G Hurdle; Fiscal Year: 2013
    ..e. probiotics), including Lactobacillus spp., to suppress gut pathogens such as C...
  44. Defining the Role of WxL Proteins in Enterococcus faecium
    ..have been implicated as important in peritonitis infections caused by Enterococcus faecalis and aggregation in Lactobacillus coryniformis. My preliminary data have shown that the WxL proteins of E...
    W Allan Walker; Fiscal Year: 2013
    ..a representative breast milk oligosaccharide, galacto-oligosaccharide and 3) the effect of Bifidobacteria and Lactobacillus, the predominantly colonizing bacteria in breast fed infants, media secretory products on the development of ..
  46. Ethanol metabolizing Lactobacillus for cancer prevention
    Lin Tao; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ethanol metabolizing Lactobacillus for cancer prevention. Mortality from colorectal cancer (CRC) is second only to that from lung cancer in men and breast cancer in women...
  47. Recombinant Lactobacillus as an Oral Mucosal Vaccine Against HIV-1
    Gregg A Dean; Fiscal Year: 2012
    ..Recently members of the lactic acid bacteria family have been explored as vaccine vectors. Lactobacillus gasseri is a common commensal of the human oral cavity and gastrointestinal tract and may be particularly ..
  48. Revealing the role of the cervico-vaginal microbiome in spontaneous preterm birth
    Michal A Elovitz; Fiscal Year: 2013
    ..We hypothesize that microbial communities in the CV space will be stably composed of Lactobacillus spp. throughout pregnancy in women who are destined to have a term delivery...
  49. Probiotics: Potential Therapeutic Roles in Diarrhea
    Pradeep K Dudeja; Fiscal Year: 2013
    ..during our previous funding cycle provided pioneering in vitro and in vivo evidence for a potential probiotic Lactobacillus acidophilus (LA) based approach for the amelioration of diarrhea...
  50. Potential Role of IL-1B Therapies for Treatment of Vasculitis of Kawasaki Disease
    Moshe Arditi; Fiscal Year: 2013
    ..The pathogenesis and molecular mechanisms are still unclear. The injection of Lactobacillus casei cell wall extract (LCCWE) to C57BL/6 mice causes a focal coronary arteritis that histopathologically ..
  51. Modulation of NF-kB Signaling by Immunoprobiotics
    James Versalovic; Fiscal Year: 2011
    ..1. Generate insertional mutants of immunoprobiotic Lactobacillus reuteri and identify key bacterial genes that regulate factors affecting NF-?B and MAP kinase signaling ..
  52. Probiotics in Pediatric Diarrhea in Peru_Supplement
    Richard A Oberhelman; Fiscal Year: 2012
    ..We propose to evaluate the relative efficacy of Lactobacillus GG (LGG) and Bifidobacterium bifidum (Bb), two promising probiotic agents, in a randomized double-blinded ..
  53. The Role of the Microbiome in the Development/Prevention of Food Allergies
    Gary B Huffnagle; Fiscal Year: 2011
    ..and lamina propria of microbiota-disrupted mice following oral delivery of OVA;2) to determine the effect of a Lactobacillus probiotic, a prebiotic (scFOS) or the combination of the two on the cellular, humoral and cytokine responses ..
  54. Probiotics to Enhance Influenza Vaccine Immunogenicity
    Patricia L Hibberd; Fiscal Year: 2013
    ..In vitro studies and animal data show that probiotics, particularly Lactobacillus GG (LGG), have immunomodulatory properties...
  55. Effects of Probiotics in Patients with Cystic Fibrosis
    Patricia L Hibberd; Fiscal Year: 2013
    ..Probiotics, particularly Lactobacillus GG (LGG) are capable of killing various bacteria, including S aureus and P aeruginosa, in vitro, by a variety ..
  56. The Semen Enhancer of HIV Infection as a Novel Microbicide Target
    Stephen Dewhurst; Fiscal Year: 2012
    ..will assess the toxicity and inflammatory effects of the most promising candidate molecules, using beneficial Lactobacillus strains and cervical explants...
  57. Probiotic Outcomes in Enteric Microflora (POEM) Study
    Michael D Cabana; Fiscal Year: 2010
    ..TIPS was designed to examine the effects of daily Lactobacillus casei supplementation in infants for 6 months on the development of early markers of asthma to age three;using ..
  58. Microbicide Loaded Nanocarriers for Topical Delivery in HIV/AIDS Prevention
    BI BOTTI CELESTIN YOUAN; Fiscal Year: 2010
    ..NC, we will thoroughly characterize the developed NC physico-chemically, assess their safety by MTT and Lactobacillus toxicity assay, test their efficacy in vitro (with seminal plasma, human PBMC-based and cervical explants ..
  59. Oral Vaccine Platform for Yersinia pestis
    Lloyd F Mayer; Fiscal Year: 2012
    ..We will achieve this goal with the following aims: Specific Aim 1. Construct and characterize Lactobacillus spp. oral Y. pestis vaccine candidates...
  60. Gastrointestinal Colonization of Diarrheagenic Clostridium difficile
    GAYATRI PH D VEDANTAM; Fiscal Year: 2013
    ..This will involve construction of a targeted CD colonization inhibitor, by engineering a probiotic bacterium (Lactobacillus acidophilus) to express the CD colonization protein SlpA...
  61. Impact of suppressive antimicrobial therapy on the vaginal microbiota and BV
    ..Interventions that promote vaginal health by increasing the prevalence and quantity of Lactobacillus species and reducing the prevalence and quantity of species associated with BV could have a substantial impact ..
  62. Innate Immunity and Mouse Model of Kawasaki Disease
    Danica Jenine Schulte; Fiscal Year: 2010
    ..Injection of a cell wall extract derived from Lactobacillus casei;LCCWE, into mice causes coronary arteritis that is histopathologically similar to the arteritis seen in ..
  63. Prevention of neonatal infection in the Indian community setting using probiotics
    Pinaki Panigrahi; Fiscal Year: 2011
    ..Using a well-defined, commercially available supplement of Lactobacillus plantarum (FDA registered in the U.S...
  64. Use of Probiotic Conditioned Media to Protect Against Necrotizing Enterocolitis
    ERIKA CLAUD; Fiscal Year: 2009
    ..the hypothesis that conditioned media (CM) obtained by filtering the broth used to grow the probiotic bacteria Lactobacillus plantarum can decrease the incidence and severity of NEC by improving intestinal host defense mechanisms, ..
  65. Developing acid-activated antimicrobial peptides to control dental caries
    Maxwell Anderson; Fiscal Year: 2009
    ..together with a limited number of acid- producing (cariogenic) bacteria such as Streptococcus mutans and Lactobacillus species...
    Greg Germaine; Fiscal Year: 1991
    ..and, in some cases, serotype levels will be prepared against oral Streptococcus, Actinomyces, Veillonella, Lactobacillus, Neisseria, Hemophilus, Bacteroides, Fusobacterium, Capnocytophaga, Actinobacillus and Treponena...
    David Eschenbach; Fiscal Year: 1999
    ..Quantitative vaginal cultures will be performed for selected species, attachment of Lactobacillus and Escherichia coli to the subject's vaginal epithelial cells will be examined and colposcopic, cytologic and ..
  68. Role of Bacterial Vaginosis in Preterm Delivery
    ROBIN ROSS; Fiscal Year: 2003
    ..Concentrations of the normally dominant Lactobacillus decrease while other microflora increase (Prevotella, Peptostreptococcus, Gardnerella, Mobiluncus)...
  69. VSL for Asthma
    Alessio Fasano; Fiscal Year: 2009
    ..Probiotics (those microbes that produce only beneficial effects in the host gut), such as Lactobacillus and Bifidobacterium are reduced in the intestinal microbiota of atopic individuals and westernized populations...
    Walter Stamm; Fiscal Year: 2007
    ..Project 1 will undertake a double-blind placebo-controlled trial to determine whether a Lactobacillus crispatis vaginal probiotic will reduce the incidence of recurrent UTIs in women...
  71. Probiotics for Infectious Diarrhea in Children in South India
    Honorine Ward; Fiscal Year: 2009
    ..Based on the established efficacy of Lactobacillus rhamnosus GG (LGG) for the treatment of a variety of diarrheal diseases and the documented modulation of ..
    GARY GERFEN; Fiscal Year: 2005
    ..cycles of glutamate mutase from Clostridium cochlearium and ribonucleoside triphosphate reductase (RTPR) from Lactobacillus leichmannIi...
  73. Mechanisms of bacterial-induced colitis in HLA-B27 rats
    LEVINUS DIELEMAN; Fiscal Year: 2002
    ..b>Lactobacillus casei GG (L.GG) can prevent the disease recurrence after treatment with antibiotics...
  74. Feasibility Study of Probiotics for Growth Faltering
    Christine Wanke; Fiscal Year: 2006
    ..will determine the feasibility of conducting a randomized-double blinded controlled study of the probiotic Lactobacillus GG (LGG) given in yogurt to infants at the time of weaning as a culturally and economically appropriate ..