gardnerella vaginalis

Summary

Summary: The only species in the genus GARDNERELLA, and previously classed as Haemophilus vaginalis. This bacterium, also isolated from the female genital tract of healthy women, is implicated in the cause of bacterial vaginosis (VAGINOSIS, BACTERIAL). It occasionally causes postpartum bacteremia and bacteremia following a transurethral resection of the prostate.

Top Publications

  1. pmc Comparative genomics of Gardnerella vaginalis strains reveals substantial differences in metabolic and virulence potential
    Carl J Yeoman
    Institute for Genomic Biology, University of Illinois, Urbana, Illinois, USA
    PLoS ONE 5:e12411. 2010
  2. ncbi Molecular identification of bacteria associated with bacterial vaginosis
    David N Fredricks
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    N Engl J Med 353:1899-911. 2005
  3. pmc Temporal variability of human vaginal bacteria and relationship with bacterial vaginosis
    Sujatha Srinivasan
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 5:e10197. 2010
  4. pmc Cloning of 16S rRNA genes amplified from normal and disturbed vaginal microflora suggests a strong association between Atopobium vaginae, Gardnerella vaginalis and bacterial vaginosis
    Rita Verhelst
    Department Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent, Belgium
    BMC Microbiol 4:16. 2004
  5. pmc Deep sequencing of the vaginal microbiota of women with HIV
    Ruben Hummelen
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Canada
    PLoS ONE 5:e12078. 2010
  6. pmc Quantitative determination by real-time PCR of four vaginal Lactobacillus species, Gardnerella vaginalis and Atopobium vaginae indicates an inverse relationship between L. gasseri and L. iners
    Ellen De Backer
    Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, UGent, Ghent, Belgium
    BMC Microbiol 7:115. 2007
  7. pmc Exploring the diversity of Gardnerella vaginalis in the genitourinary tract microbiota of monogamous couples through subtle nucleotide variation
    A Murat Eren
    Department of Computer Science, University of New Orleans, New Orleans, Louisiana, United States of America
    PLoS ONE 6:e26732. 2011
  8. pmc The aetiology of bacterial vaginosis
    Y Turovskiy
    Rutgers, The State University of New Jersey, New Brunswick, NJ, USA
    J Appl Microbiol 110:1105-28. 2011
  9. pmc Drawing the line between commensal and pathogenic Gardnerella vaginalis through genome analysis and virulence studies
    Michael D Harwich
    Department of Microbiology and Immunology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA 23298, USA
    BMC Genomics 11:375. 2010
  10. ncbi An adherent Gardnerella vaginalis biofilm persists on the vaginal epithelium after standard therapy with oral metronidazole
    Alexander Swidsinski
    Molekulargenetisches Labor für polymikrobielle Infektionen und bakterielle Biofilme, Berlin, Germany
    Am J Obstet Gynecol 198:97.e1-6. 2008

Detail Information

Publications195 found, 100 shown here

  1. pmc Comparative genomics of Gardnerella vaginalis strains reveals substantial differences in metabolic and virulence potential
    Carl J Yeoman
    Institute for Genomic Biology, University of Illinois, Urbana, Illinois, USA
    PLoS ONE 5:e12411. 2010
    b>Gardnerella vaginalis is described as a common vaginal bacterial species whose presence correlates strongly with bacterial vaginosis (BV). Here we report the genome sequencing and comparative analyses of three strains of G. vaginalis...
  2. ncbi Molecular identification of bacteria associated with bacterial vaginosis
    David N Fredricks
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    N Engl J Med 353:1899-911. 2005
    ..The cause of bacterial vaginosis remains poorly understood despite numerous studies based on cultures. Bacteria in microbial communities can be identified without cultivation by characterizing their ribosomal DNA (rDNA) sequences...
  3. pmc Temporal variability of human vaginal bacteria and relationship with bacterial vaginosis
    Sujatha Srinivasan
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 5:e10197. 2010
    ..This study used PCR to assess the variability in concentrations of key vaginal bacteria in healthy women and the immediate response to antibiotic treatment in women with bacterial vaginosis (BV)...
  4. pmc Cloning of 16S rRNA genes amplified from normal and disturbed vaginal microflora suggests a strong association between Atopobium vaginae, Gardnerella vaginalis and bacterial vaginosis
    Rita Verhelst
    Department Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent, Belgium
    BMC Microbiol 4:16. 2004
    The pathogenesis of bacterial vaginosis remains largely elusive, although some microorganisms, including Gardnerella vaginalis, are suspected of playing a role in the etiology of this disorder...
  5. pmc Deep sequencing of the vaginal microbiota of women with HIV
    Ruben Hummelen
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Canada
    PLoS ONE 5:e12078. 2010
    ..It is poorly understood which bacterial communities constitute BV or the normal vaginal microbiota among this population and how the microbiota associated with BV responds to antibiotic treatment...
  6. pmc Quantitative determination by real-time PCR of four vaginal Lactobacillus species, Gardnerella vaginalis and Atopobium vaginae indicates an inverse relationship between L. gasseri and L. iners
    Ellen De Backer
    Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, UGent, Ghent, Belgium
    BMC Microbiol 7:115. 2007
    ..Here we applied existing real-time PCR formats for Lactobacillus crispatus, L. gasseri and Gardnerella vaginalis and developed new formats for Atopobium vaginae, L. iners and L...
  7. pmc Exploring the diversity of Gardnerella vaginalis in the genitourinary tract microbiota of monogamous couples through subtle nucleotide variation
    A Murat Eren
    Department of Computer Science, University of New Orleans, New Orleans, Louisiana, United States of America
    PLoS ONE 6:e26732. 2011
    ..vaginalis biotypes, as well as more recent genomic comparisons of G. vaginalis isolates from symptomatic and asymptomatic women, suggest that particular G. vaginalis strains may play a key role in the pathogenesis of BV...
  8. pmc The aetiology of bacterial vaginosis
    Y Turovskiy
    Rutgers, The State University of New Jersey, New Brunswick, NJ, USA
    J Appl Microbiol 110:1105-28. 2011
    ..Many of these factors are yet to be characterized because a clear understanding of their relative contribution to the aetiology of BV is pivotal to the formulation of an effective treatment for and prophylaxis of this condition...
  9. pmc Drawing the line between commensal and pathogenic Gardnerella vaginalis through genome analysis and virulence studies
    Michael D Harwich
    Department of Microbiology and Immunology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA 23298, USA
    BMC Genomics 11:375. 2010
    ..b>Gardnerella vaginalis was originally identified as the causative agent, but subsequent findings that it is commonly isolated ..
  10. ncbi An adherent Gardnerella vaginalis biofilm persists on the vaginal epithelium after standard therapy with oral metronidazole
    Alexander Swidsinski
    Molekulargenetisches Labor für polymikrobielle Infektionen und bakterielle Biofilme, Berlin, Germany
    Am J Obstet Gynecol 198:97.e1-6. 2008
    ..The purpose of this study was to determine the efficacy of standard treatment with oral metronidazole in the eradication of the bacterial vaginosis biofilm...
  11. ncbi The genital econiche: focus on microbiota and bacterial vaginosis
    Dan Danielsson
    Department of Clinical Microbiology and Immunology, Division of Laboratory Medicine, University Hospital, Orebro, Sweden
    Ann N Y Acad Sci 1230:48-58. 2011
    ..Recent studies have implicated the development of a vaginal biofilm with Gardnerella vaginalis and Atopobium vaginae as main players in the pathogenesis of bacterial vaginosis...
  12. ncbi Female genital-tract HIV load correlates inversely with Lactobacillus species but positively with bacterial vaginosis and Mycoplasma hominis
    Beverly E Sha
    Department of Medicine, Section of Infectious Diseases, Rush University Medical Center, University of Illinois at Chicago, Illinois, USA
    J Infect Dis 191:25-32. 2005
    ..Bacterial vaginosis (BV) is associated with human immunodeficiency virus (HIV) acquisition. We examined the association between BV and BV-associated bacteria and expression of HIV in the female genital tract...
  13. ncbi Gardnerella vaginalis comprises three distinct genotypes of which only two produce sialidase
    Guido Lopes Dos Santos Santiago
    Department of Clinical Chemistry, Microbiology, and Immunology, Laboratory for Bacteriology Research, Faculty of Medicine and Health Sciences, Ghent University, Belgium
    Am J Obstet Gynecol 204:450.e1-7. 2011
    Sialidase and the presence of Gardnerella vaginalis have been proposed as biomarkers for bacterial vaginosis. Sialidase has been associated with adverse pregnancy outcome...
  14. ncbi Response of Gardnerella vaginalis biofilm to 5 days of moxifloxacin treatment
    Alexander Swidsinski
    Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, Charite Universitatsmedizin Berlin, Berlin, Germany
    FEMS Immunol Med Microbiol 61:41-6. 2011
    Polymicrobial communities are often recalcitrant to antibiotics. We tested whether the polymicrobial Gardnerella vaginalis biofilm can be eradicated with moxifloxacin...
  15. ncbi In vitro secretion profile of pro-inflammatory cytokines IL-1β, TNF-α, IL-6, and of human beta-defensins (HBD)-1, HBD-2, and HBD-3 from human chorioamniotic membranes after selective stimulation with Gardnerella vaginalis
    Veronica Zaga-Clavellina
    Cell Biology Department, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City, Mexico
    Am J Reprod Immunol 67:34-43. 2012
    Preterm labor associated with infection is a major clinical condition; in this work, we analyze the response of human chorioamniotic membranes stimulated with Gardnerella vaginalis.
  16. ncbi Genetic and biochemical diversity of Gardnerella vaginalis strains isolated from women with bacterial vaginosis
    Milda Pleckaityte
    Institute of Biotechnology, Vilnius University, Vilnius, Lithuania
    FEMS Immunol Med Microbiol 65:69-77. 2012
    b>Gardnerella vaginalis is considered a substantial player in the progression of bacterial vaginosis (BV). We analysed 17 G...
  17. ncbi Detection of bacterial vaginosis-related organisms by real-time PCR for Lactobacilli, Gardnerella vaginalis and Mycoplasma hominis
    M Reza Zariffard
    Department of Immunology Microbiology, Rush University, 1653 West Congress Parkway, Chicago, IL 60612, USA
    FEMS Immunol Med Microbiol 34:277-81. 2002
    ..lavage (CVL) samples from 21 women were analyzed by real-time PCR for the numbers of Mycoplasma hominis, Gardnerella vaginalis and lactobacilli. Lactobacilli organisms were detected in all CVL samples, G...
  18. ncbi In vitro inhibitory activity of human vaginal lactobacilli against pathogenic bacteria associated with bacterial vaginosis in Kenyan women
    Martin N Matu
    Department of Biochemistry and Biotechnology, Kenyatta University, P O Box 43844, 00100 Nairobi, Kenya
    Anaerobe 16:210-5. 2010
    ..fragilis while 23% (37/158), 28% (45/158) and 29% (46/158) inhibited the growth of Prevotella bivia, Gardnerella vaginalis and Mobiluncus spp. respectively. The lactobacilli produced supernatants with a pH range between 2...
  19. pmc Resolution and characterization of distinct cpn60-based subgroups of Gardnerella vaginalis in the vaginal microbiota
    Teenus Paramel Jayaprakash
    Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    PLoS ONE 7:e43009. 2012
    ..The Nugent score, based on Gram stain, is used to diagnose BV and Gardnerella vaginalis abundance in the sample is one factor determining Nugent score...
  20. ncbi Dissimilarity in the occurrence of Bifidobacteriaceae in vaginal and perianal microbiota in women with bacterial vaginosis
    Alexander Swidsinski
    Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, 10098 Berlin, Germany
    Anaerobe 16:478-82. 2010
    ..vaginosis, the most common perturbation of the vaginal microflora involving primarily overgrowth of Gardnerella vaginalis, has also been suggested to involve a recto-vaginal pathway...
  21. pmc Comparative genomic analyses of 17 clinical isolates of Gardnerella vaginalis provide evidence of multiple genetically isolated clades consistent with subspeciation into genovars
    Azad Ahmed
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, USA
    J Bacteriol 194:3922-37. 2012
    b>Gardnerella vaginalis is associated with a spectrum of clinical conditions, suggesting high degrees of genetic heterogeneity among stains. Seventeen G...
  22. pmc Extravaginal reservoirs of vaginal bacteria as risk factors for incident bacterial vaginosis
    Jeanne M Marrazzo
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, WA, USA
    J Infect Dis 205:1580-8. 2012
    ..to diverse anaerobes. Although antibiotics relieve symptoms and temporarily eradicate BV-associated bacteria (BVAB), BV usually recurs. We investigated the role of extravaginal BVAB reservoirs in recurrence...
  23. ncbi Biotypes and virulence factors of Gardnerella vaginalis isolated from cases of bacterial vaginosis
    J Udayalaxmi
    Department of Microbiology, Kasturba Medical College, Manipal University, Mangalore 575 001, India
    Indian J Med Microbiol 29:165-8. 2011
    The present study was conducted to correlate the biotypes of Gardnerella vaginalis strains isolated from cases of bacterial vaginosis and their virulence factors. Thirty-two strains of G...
  24. pmc Longitudinal qPCR study of the dynamics of L. crispatus, L. iners, A. vaginae, (sialidase positive) G. vaginalis, and P. bivia in the vagina
    Guido Lopes Dos Santos Santiago
    Laboratory for Bacteriology Research, Department of Clinical Chemistry, Microbiology, and Immunology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
    PLoS ONE 7:e45281. 2012
    ..To obtain more detailed understanding of the causes of disturbance of the vaginal microflora (VMF), a longitudinal study was carried out for 17 women during two menstrual cycles...
  25. ncbi [Biotypes and antibiotic resistance patterns of Gardnerella vaginalis strains isolated from healthy women and women with bacterial vaginosis]
    Ilknur Tosun
    Karadeniz Teknik Universitesi Tip Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Trabzon
    Mikrobiyol Bul 41:21-7. 2007
    As Gardnerella vaginalis is accepted as a member of normal vaginal flora, it is one of the dominant species which has been related to bacterial vaginosis (BV)...
  26. ncbi Correlation of local interleukin-8 with immunoglobulin A against Gardnerella vaginalis hemolysin and with prolidase and sialidase levels in women with bacterial vaginosis
    Sabina Cauci
    Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Piazzale Kolbe 4, 33100 Udine, Italy
    J Infect Dis 185:1614-20. 2002
    ..Concentrations of sialidase, prolidase, and anti-Gardnerella vaginalis hemolysin (Gvh) immunoglobulin A (IgA) were higher in vaginal fluids of 75 fertile women with BV, compared ..
  27. ncbi Gardnerella biofilm involves females and males and is transmitted sexually
    Alexander Swidsinski
    Laboratory for Molecular Genetics, Charite, Gastroenterology, Berlin, Germany alexander swidsinski charite de
    Gynecol Obstet Invest 70:256-63. 2010
    To study the incidence and distribution of adherent Gardnerella vaginalis.
  28. ncbi High vaginal concentrations of Atopobium vaginae and Gardnerella vaginalis in women undergoing preterm labor
    Jean Pierre Menard
    Department of Obstetrics and Gynecology, Marseille Public Hospital System APHM, Marseille, France
    Obstet Gynecol 115:134-40. 2010
    ..To estimate the relationship between vaginal quantification of the main microorganisms related with bacterial vaginosis and the risk of preterm delivery among women with preterm labor...
  29. ncbi Gardnerella vaginalis isolated from patients with bacterial vaginosis and from patients with healthy vaginal ecosystems
    A A Aroutcheva
    Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Clin Infect Dis 33:1022-7. 2001
    The differences in the phenotype and genotype of Gardnerella vaginalis isolates from patients with bacterial vaginosis (BV) and from patients without BV are unknown. In our study, 43 isolates of G...
  30. ncbi Correlation of local interleukin-1beta levels with specific IgA response against Gardnerella vaginalis cytolysin in women with bacterial vaginosis
    Sabina Cauci
    Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Italy
    Am J Reprod Immunol 47:257-64. 2002
    ....
  31. pmc Glycerol monolaurate inhibits Candida and Gardnerella vaginalis in vitro and in vivo but not Lactobacillus
    Kristi L Strandberg
    Department of Microbiology, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Antimicrob Agents Chemother 54:597-601. 2010
    We investigated the effects of glycerol monolaurate (GML) on Lactobacillus, Candida, and Gardnerella vaginalis human vaginal microflora...
  32. pmc Functional and phylogenetic characterization of Vaginolysin, the human-specific cytolysin from Gardnerella vaginalis
    Shari E Gelber
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Bacteriol 190:3896-903. 2008
    Pore-forming toxins are essential to the virulence of a wide variety of pathogenic bacteria. Gardnerella vaginalis is a bacterial species associated with bacterial vaginosis (BV) and its significant adverse sequelae, including preterm ..
  33. ncbi Bacterial vaginosis: what is physiological in vaginal bacteriology? An update and opinion
    Pentti A Leppäluoto
    Acta Obstet Gynecol Scand 90:1302-6. 2011
    ..vaginosis, characterized by low vaginal acidity (elevated pH) and replacement of vaginal Lactobacillus by Gardnerella vaginalis flora, could be caused by unprotected intercourse when a low pH changes through the neutralizing power of ..
  34. ncbi A multiplex polymerase chain reaction-based diagnostic method for bacterial vaginosis
    Mana Obata-Yasuoka
    Department of Obstetrics and Gynecology, Institute of Clinical Medicine, Tsukuba, Japan
    Obstet Gynecol 100:759-64. 2002
    ..To develop a polymerase chain reaction (PCR)-based diagnostic method for bacterial vaginosis using bacterial vaginosis-associated anaerobes...
  35. ncbi Antibiotic resistance of Gardnerella vaginalis in recurrent bacterial vaginosis
    P Nagaraja
    Department of Microbiology, Farwaniya Hospital, Post Box 18373, Kuwait 81004, State of Kuwait
    Indian J Med Microbiol 26:155-7. 2008
    Fifty strains of Gardnerella vaginalis isolated from 321 high vaginal swabs over a period of five months were tested for their antibiotic sensitivity...
  36. pmc DNA hybridization test: rapid diagnostic tool for excluding bacterial vaginosis in pregnant women with symptoms suggestive of infection
    Armin Witt
    Department of Obstetrics and Gynecology, University of Vienna Medical School, Austria
    J Clin Microbiol 40:3057-9. 2002
    ..The DNA hybridization test compared well with Gram stain and can be used as a rapid diagnostic tool to exclude bacterial vaginosis...
  37. ncbi Frequency of Trichomonas vaginalis, Candida sp and Gardnerella vaginalis in cervical-vaginal smears in four different decades
    S J Adad
    Discipline of Special Pathology, Faculdade de Medicina do Triangulo Mineiro, Uberaba, Brazil
    Sao Paulo Med J 119:200-5. 2001
    ..Vaginitis is one of the principal motives that lead women to seek out an obstetrician or gynecologist. Bacterial vaginosis, candidiasis and trichomoniasis are responsible for 90% of the cases of infectious vaginitis...
  38. pmc In vitro activities of Garenoxacin (BMS 284756) against 108 clinical isolates of Gardnerella vaginalis
    Ellie J C Goldstein
    R M Alden Research Laboratory, Santa Monica University of California Los Angeles Medical Center, 90404, USA
    Antimicrob Agents Chemother 46:3995-6. 2002
    Garenoxacin (BMS 284756) was active against 105 of 108 (97%) recent clinical Gardnerella vaginalis isolates at < or =2 micro g/ml by using the reference agar dilution method for anaerobes...
  39. ncbi Antagonism and synergism in Gardnerella vaginalis strains isolated from women with bacterial vaginosis
    G S Teixeira
    Departamento de Microbiologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    J Med Microbiol 59:891-7. 2010
    ..In the present study, such compounds produced by Gardnerella vaginalis strains isolated from women with bacterial vaginosis (BV) were detected in vitro and the antagonistic ones ..
  40. ncbi Artemisia princeps Pamp. Essential oil and its constituents eucalyptol and α-terpineol ameliorate bacterial vaginosis and vulvovaginal candidiasis in mice by inhibiting bacterial growth and NF-κB activation
    Hien Trung Trinh
    Department of Life and Pharmaceutical Sciences, Kyung Hee University, Seoul, Korea
    Planta Med 77:1996-2002. 2011
    ..against bacterial vaginosis and vulvovaginal candidiasis, their antimicrobial activities against Gardnerella vaginalis and Candida albicans in vitro and their anti-inflammatory effects against G...
  41. ncbi Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae
    Hans Verstraelen
    Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, B 9000 Ghent, Belgium
    J Reprod Immunol 79:163-73. 2009
    ..condition characterised by the presence of a vaginal biofilm consisting of the Gram-positive anaerobes Gardnerella vaginalis and Atopobium vaginae...
  42. ncbi Bacterial vaginosis a "broad overview"
    A González Pedraza Avilés
    C S C Dr José Castro Villagrana, Departamento de Medicina Familiar, Facultad de Medicina, UNAM, Instituto de Servicios de Salud del Distrito Federal, Mexico D F
    Rev Latinoam Microbiol 41:25-34. 1999
    ..also described a "new" causative organism, which they named "Haemophilus vaginalis", subsequently renamed Gardnerella vaginalis. BV is currently the most prevalent cause of infectious vaginitis among women attending for genitourinary ..
  43. pmc Evidence for Gardnerella vaginalis uptake and internalization by squamous vaginal epithelial cells: implications for the pathogenesis of bacterial vaginosis
    Christy N Marrs
    Meharry Medical College, School of Medicine, Center for AIDS Health Disparities Research, Hubbard Hospital, Nashville, TN 37208, USA
    Microbes Infect 14:500-8. 2012
    ..b>Gardnerella vaginalis is the predominant bacterial species associated with BV, although its exact role in the pathology of BV is ..
  44. ncbi Self-collected vaginal swabs for the quantitative real-time polymerase chain reaction assay of Atopobium vaginae and Gardnerella vaginalis and the diagnosis of bacterial vaginosis
    J P Menard
    Service de Gynecologie Obstetrique, Hôpital Nord Marseille, Chemin des Bourrely, 13915, Marseille, France
    Eur J Clin Microbiol Infect Dis 31:513-8. 2012
    ..748 for Atopobium vaginae, 0.918 for Lactobacillus species, 0.940 for Gardnerella vaginalis; p < 0.001), especially for high concentrations of A...
  45. ncbi Rates of bacterial vaginosis in women undergoing in vitro fertilisation for different types of infertility
    Janet D Wilson
    The General Infirmary at Leeds, UK
    BJOG 109:714-7. 2002
    ..To assess whether the rate of bacterial vaginosis (BV) is higher in women with tubal factor infertility compared with those with other causes of infertility...
  46. pmc The natural antimicrobial peptide subtilosin acts synergistically with glycerol monolaurate, lauric arginate, and ε-poly-L-lysine against bacterial vaginosis-associated pathogens but not human lactobacilli
    Katia Sutyak Noll
    Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA
    Antimicrob Agents Chemother 56:1756-61. 2012
    ..that has antimicrobial activity against the bacterial vaginosis-associated human pathogen Gardnerella vaginalis. The ability of subtilosin to inhibit G...
  47. ncbi Lactobacillus johnsonii HY7042 ameliorates Gardnerella vaginalis-induced vaginosis by killing Gardnerella vaginalis and inhibiting NF-κB activation
    Hyun Min Joo
    Department of Food and Nutrition, Kyung Hee University, 1, Hoegi, Dongdaemun ku, Seoul 130 701, Republic of Korea
    Int Immunopharmacol 11:1758-65. 2011
    ..lactic acid bacteria (LAB) were isolated from women's vaginas and their anti-inflammatory effects against Gardnerella vaginalis-induced vaginosis were examined in β-estradiol-immunosuppressed mice...
  48. ncbi Activation of human immunodeficiency virus type 1 expression by Gardnerella vaginalis
    F B Hashemi
    Department of Immunology Microbiology, Rush University, Chicago, IL 60612, USA
    J Infect Dis 179:924-30. 1999
    ..associated with an increased rate of sexual transmission of human immunodeficiency virus (HIV) type 1, and Gardnerella vaginalis is frequently isolated from the genital tracts of women with BV. G...
  49. ncbi Gardnerella vaginalis septicaemia with pyelonephritis, infective endocarditis and septic emboli in the kidney and brain of an adult male
    H J Yoon
    Department of Internal Medicine, Eulji University College of Medicine, Daejeon, Korea
    Int J STD AIDS 21:653-7. 2010
    b>Gardnerella vaginalis is typically associated with bacterial vaginosis in women. However, balanitis, urethritis, urinary tract infections and asymptomatic bacteraemia have also been described in men. Here we report a case of G...
  50. ncbi Cytologically diagnosed Gardnerella vaginalis infection and cervical (pre)neoplasia as established in population-based cervical screening
    Johanna M Klomp
    Leiden Cytology and Pathology Laboratory, Leiden, The Netherlands
    Am J Obstet Gynecol 199:480.e1-5. 2008
    ..The purpose of this study was to document the prevalence of cervical (pre)neoplastic changes in asymptomatic women with a cytologically diagnosed Gardnerella vaginalis infection.
  51. ncbi Inhibitory activity of thymol on native and mature Gardnerella vaginalis biofilms: in vitro study
    Pier Carlo Braga
    Department of Pharmacology, School of Medicine, University of Milan, Italy
    Arzneimittelforschung 60:675-81. 2010
    ..with BV show the growth of bacteria in the form of biofilms as against only 10% without BV, and that Gardnerella vaginalis was the predominant species. The propensity of G...
  52. ncbi Bacterial vaginosis and risk of pelvic inflammatory disease
    Roberta B Ness
    University of Pittsburgh, Graduate School of Public Health, Magee Womens Hospital and Research Institute, Pittsburgh, PA 15261, USA
    Obstet Gynecol 104:761-9. 2004
    ..Bacterial vaginosis commonly is found in women with pelvic inflammatory disease (PID), but it is unclear whether bacterial vaginosis leads to incident PID...
  53. pmc Utility of Amsel criteria, Nugent score, and quantitative PCR for Gardnerella vaginalis, Mycoplasma hominis, and Lactobacillus spp. for diagnosis of bacterial vaginosis in human immunodeficiency virus-infected women
    Beverly E Sha
    Department of Medicine, Section of Infectious Diseases, Rush University Medical Center, Chicago, IL 60612, USA
    J Clin Microbiol 43:4607-12. 2005
    ..Lactobacilli, Gardnerella vaginalis, and Mycoplasma hominis in cervicovaginal lavage samples were quantified by PCR...
  54. ncbi The association of Atopobium vaginae and Gardnerella vaginalis with bacterial vaginosis and recurrence after oral metronidazole therapy
    C S Bradshaw
    Melbourne Sexual Health Centre, The Alfred Hospital, Carlton, 3053, Victoria, Australia
    J Infect Dis 194:828-36. 2006
    ..We investigated associations between Atopobium vaginae and bacterial vaginosis (BV) and the role that A. vaginae plays in recurrent BV after oral metronidazole therapy...
  55. ncbi Lactobacillus strains isolated from the vaginal microbiota of healthy women inhibit Prevotella bivia and Gardnerella vaginalis in coculture and cell culture
    Fabrice Atassi
    INSERM and Université Paris XI, Faculte de Pharmacie, Chatenay Malabry, France
    FEMS Immunol Med Microbiol 48:424-32. 2006
    ..jensenii, Lactobacillus gasseri and Lactobacillus crispatus inhibit the vaginosis-associated pathogens Gardnerella vaginalis and Prevotella bivia. Results show that all the strains in coculture condition reduced the viability of G...
  56. ncbi Probiotics for the treatment of women with bacterial vaginosis
    M E Falagas
    Alfa Institute of Biomedical Sciences, Marousi, Greece
    Clin Microbiol Infect 13:657-64. 2007
    ..studies have suggested that certain specific strains of lactobacilli are able to inhibit the adherence of Gardnerella vaginalis to the vaginal epithelium and/or produce H2O2, lactic acid and/or bacteriocins, which inhibit the growth ..
  57. ncbi The polymicrobial hypothesis of bacterial vaginosis causation: a reassessment
    W E Josey
    Department of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA
    Int J STD AIDS 19:152-4. 2008
    The cause of bacterial vaginosis remains controversial. The two leading hypotheses are that Gardnerella vaginalis is the specific aetiologic agent versus the polymicrobial hypothesis that G...
  58. pmc Vaginal microflora associated with bacterial vaginosis in nonpregnant women: reliability of sialidase detection
    J Smayevsky
    Laboratorio de Microbiologia, Centro de Educación Médica e Investigaciones Clínicas Dr Norberto Quirno CEMIC, Buenos Aires, Argentina
    Infect Dis Obstet Gynecol 9:17-22. 2001
    To determine the prevalence of Gardnerella vaginalis, anaerobic bacteria and Mycoplasma hominis in vaginal specimens of women with and without bacterial vaginosis (BV) as well as to determine the sensitivity and specificity of the direct ..
  59. ncbi Characterization of vaginal microflora of healthy, nonpregnant women by chaperonin-60 sequence-based methods
    Janet E Hill
    National Research Council of Canada, Plant Biotechnology Institute, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Am J Obstet Gynecol 193:682-92. 2005
    ..The purpose of this study was to use a novel method that was based on the application of chaperonin-60 sequencing to describe the vaginal microflora of 16 healthy women...
  60. pmc Effect of biofilm phenotype on resistance of Gardnerella vaginalis to hydrogen peroxide and lactic acid
    Jennifer L Patterson
    Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Obstet Gynecol 197:170.e1-7. 2007
    ..H2O2 and lactic acid, which normally suppress growth of anaerobes; however, in bacterial vaginosis, Gardnerella vaginalis and other anaerobes proliferate, and the number of lactobacilli decreases. G...
  61. ncbi Molecular quantification of Gardnerella vaginalis and Atopobium vaginae loads to predict bacterial vaginosis
    Jean Pierre Menard
    Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Clin Infect Dis 47:33-43. 2008
    ..Bacterial vaginosis (BV) is a poorly detected public health problem that is associated with preterm delivery and for which no reliable diagnostic tool exists...
  62. pmc Antibiotic susceptibility of Atopobium vaginae
    Ellen De Backer
    Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent, Belgium
    BMC Infect Dis 6:51. 2006
    ..Thus far the four isolates of this fastidious micro-organism were found to be highly resistant to metronidazole and susceptible for clindamycin, two antibiotics preferred for the treatment of BV...
  63. pmc Comparison between Gram stain and culture for the characterization of vaginal microflora: definition of a distinct grade that resembles grade I microflora and revised categorization of grade I microflora
    Rita Verhelst
    Department Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, UGent, Ghent, Belgium
    BMC Microbiol 5:61. 2005
    ..purpose we compared Gram stain based categorization of vaginal smears with i) species specific PCR for the detection of Gardnerella vaginalis and Atopobium vaginae and with ii) tDNA-PCR for the identification of most cultivable species.
  64. pmc Gardnerella vaginalis bacteremia in a previously healthy man: case report and characterization of the isolate
    Philippe R S Lagacé-Wiens
    Department of Medical Microbiology and Infectious Diseases, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Clin Microbiol 46:804-6. 2008
    b>Gardnerella vaginalis in women causes vaginitis or infections in other sites, such as the urinary tract, but is an infrequent cause of bacteremia. Bacteremia in men is very rare and is typically associated with immunocompromised states...
  65. ncbi Prevalence of Gardnerella vaginalis and Atopobium vaginae in virginal women
    Sepehr N Tabrizi
    Department of Microbiology and Infectious Diseases, The Royal Women s Hospital, 132 Grattan Street, Victoria 3053, Australia
    Sex Transm Dis 33:663-5. 2006
    The objectives of this study was to determine the prevalence of Gardnerella vaginalis and Atopobium vaginae in virginal women and to establish if nonpenetrative sexual activity is associated with these organisms.
  66. ncbi Effect of Lactobacillus challenge on Gardnerella vaginalis biofilms
    Sheri Saunders
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, F2 116, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
    Colloids Surf B Biointerfaces 55:138-42. 2007
    ..b>Gardnerella vaginalis is commonly associated with these infections. Microscopy analysis showed that within 72 h, viable G...
  67. pmc Isolation of the Bacillus subtilis antimicrobial peptide subtilosin from the dairy product-derived Bacillus amyloliquefaciens
    K E Sutyak
    Rutgers, The State University of New Jersey, Piscataway, NJ, USA
    J Appl Microbiol 104:1067-74. 2008
    ..To purify and characterize an antimicrobial protein (bacteriocin) isolated from the dairy product-derived Bacillus amyloliquefaciens...
  68. ncbi Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis
    Fabio Peixoto
    Laboratory of Human Reproduction, Teaching Hospital, Federal University of Minas Gerais, Brazil
    Int J Gynaecol Obstet 102:287-92. 2008
    ..To evaluate the efficacy and tolerability of a vaginal pessary containing 750 mg of metronidazole and 200 mg of miconazole nitrate used daily for 7 days in the treatment of vaginitis...
  69. ncbi Human immunodeficiency virus type 1 stimulatory activity by Gardnerella vaginalis: relationship to biotypes and other pathogenic characteristics
    J A Simoes
    Departments of Obstetrics and Gynecology, Rush Medical College, Chicago, Illinois 60612, USA
    J Infect Dis 184:22-7. 2001
    Stimulation of human immunodeficiency virus (HIV) type 1 expression by Gardnerella vaginalis is one possible cause for an increase in the amount of virus in the genital tract. The ability of G...
  70. ncbi Production and characterization of monoclonal antibodies against vaginolysin: mapping of a region critical for its cytolytic activity
    Aurelija Zvirbliene
    Institute of Biotechnology, V Graiciuno 8, LT 02241 Vilnius, Lithuania
    Toxicon 56:19-28. 2010
    Vaginolysin (VLY) is a protein toxin released by Gardnerella vaginalis. VLY belongs to the group of cholesterol-dependent cytolysins (CDCs). We have generated a panel of novel monoclonal antibodies (MAbs) against VLY...
  71. ncbi Vaginal hydrolytic enzymes, immunoglobulin A against Gardnerella vaginalis toxin, and risk of early preterm birth among women in preterm labor with bacterial vaginosis or intermediate flora
    Sabina Cauci
    Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Udine, Italy
    Am J Obstet Gynecol 187:877-81. 2002
    ..whether the microbial hydrolytic enzymes, sialidase and prolidase, and immunoglobulin A against the Gardnerella vaginalis cytolysin (anti-Gvh IgA) increase the risk for early preterm birth (< or =34 weeks of gestation) among ..
  72. ncbi Gardnerella vaginalis bacteremia in a premature neonate
    Rene A Amaya
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Perinatol 22:585-7. 2002
    b>Gardnerella vaginalis is a normal component of the human vaginal flora and commonly associated with bacterial vaginosis. Invasive infection in obstetrical patients due to G. vaginalis has also been reported...
  73. pmc Two novel vaginal microbicides (polystyrene sulfonate and cellulose sulfate) inhibit Gardnerella vaginalis and anaerobes commonly associated with bacterial vaginosis
    Jose A Simoes
    Department of Obstetrics and Gynecology, Rush University, Rush Presbyterian St Luke s Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
    Antimicrob Agents Chemother 46:2692-5. 2002
    ..Vaginal application of these microbicides not only may reduce the risk of acquisition of human immunodeficiency virus and other sexually transmitted infection-causing organisms but may also decrease the incidence of BV...
  74. ncbi Characterization of vaginal flora and bacterial vaginosis in women who have sex with women
    Jeanne M Marrazzo
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 185:1307-13. 2002
    ..These data support the hypothesis that sexual exchange of vaginal secretions is a possible mechanism for acquisition of BV...
  75. ncbi Bacteriocin susceptibility of Gardnerella vaginalis and its relationship to biotype, genotype, and metronidazole susceptibility
    J A Simoes
    Department of Obstetrics and Gynecology, Rush Medical College, Chicago, Ill, USA
    Am J Obstet Gynecol 185:1186-90. 2001
    OBJECTIVE: Our purpose was to investigate the bacteriocin susceptibility of Gardnerella vaginalis and its relationship to biotype, genotype, and resistance to metronidazole...
  76. ncbi Definition of a type of abnormal vaginal flora that is distinct from bacterial vaginosis: aerobic vaginitis
    Gilbert G G Donders
    Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Catholic University of Leuven, Belgium
    BJOG 109:34-43. 2002
    ..To define an entity of abnormal vaginal flora: aerobic vaginitis...
  77. pmc Analysis of adherence, biofilm formation and cytotoxicity suggests a greater virulence potential of Gardnerella vaginalis relative to other bacterial-vaginosis-associated anaerobes
    Jennifer L Patterson
    Department of Microbiology and Immunology, PO Box 980678, Virginia Commonwealth University, Richmond, VA 23928, USA
    Microbiology 156:392-9. 2010
    ..In most cases of BV, the predominant bacterial species found is Gardnerella vaginalis. However, pure cultures of G...
  78. ncbi Vertebral osteomyelitis and discitis due to Gardnerella vaginalis
    Simon Graham
    Academic Department of Trauma and Orthopaedics, University of Leeds, School of Medicine, Clarendon Wing A, Leeds General Infirmary Teaching Hospitals NHS Trust, Great George Street, Leeds LS1 3EX, UK
    J Med Microbiol 58:1382-4. 2009
    b>Gardnerella vaginalis is a facultative anaerobic Gram-variable pleomorphic rod that forms part of the normal vaginal flora. It is most commonly associated with infection of the genital tract in women, but recognition of extravaginal G...
  79. pmc Antibody-based detection and inhibition of vaginolysin, the Gardnerella vaginalis cytolysin
    Tara M Randis
    Department of Pediatrics, Columbia University, New York, NY, USA
    PLoS ONE 4:e5207. 2009
    ..We have recently characterized vaginolysin (VLY), the human-specific cytotoxin produced by Gardnerella vaginalis and believed to play a critical role in the pathogenesis of BV and its associated morbidities...
  80. ncbi Importance of isolation and biotypization of Gardnerella vaginalis in diagnosis of bacterial vaginosis
    Fatima Numanovic
    Polyclinic for Laboratory Diagnostics, Department for Microbiology, University Clinics Centre Tuzla, Trnovac bb, 75 000 Tuzla, Bosnia and Herzegovina
    Bosn J Basic Med Sci 8:270-6. 2008
    The natural habitat of Gardnerella vaginalis is a vagina since it could be located among 69% of women who have no signs of vaginal infection and in the vagina of as many as 13.5% girls. G...
  81. pmc Acquisition of iron by Gardnerella vaginalis
    G P Jarosik
    Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    Infect Immun 66:5041-7. 1998
    Six Gardnerella vaginalis strains were examined for the ability to utilize various iron-containing compounds as iron sources...
  82. ncbi Vaginal microflora in healthy women with Gardnerella vaginalis
    H Mikamo
    Department of Obstetrics and Gynecology, School of Medicine, Gifu University, 40 Tsukasa Machi, Gifu 500 8705, Japan
    J Infect Chemother 6:173-7. 2000
    In order to find the vaginal prevalence of Gardnerella vaginalis in a normal female population, we determined the incidence of G. vaginalis in relation to that of other bacterial genera and species in the vagina...
  83. pmc Antimicrobial protein produced by vaginal Lactobacillus acidophilus that inhibits Gardnerella vaginalis
    A A Aroutcheva
    Department of Obstetrics and Gynecology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA
    Infect Dis Obstet Gynecol 9:33-9. 2001
    ..growth-inhibiting activity of bacteriocin was determined by a bioassay using nine different isolates of Gardnerella vaginalis. RESULTS: MRS broth is not a suitable medium for extracting bacteriocin, because it binds with Tween 80...
  84. pmc Gardnerella vaginalis acute hip arthritis in a renal transplant recipient
    Valérie Sivadon-Tardy
    Laboratoire de Microbiologie, Hopital Raymond Poincare, 104 Bd Raymond Poincaré, 92380 Garches, France
    J Clin Microbiol 47:264-5. 2009
    We report the case of an acute hip septic arthritis caused by Gardnerella vaginalis in a 48-year-old woman under immunosuppressive therapy for kidney transplantation...
  85. ncbi Detection of Bifidobacterium species and Gardnerella vaginalis in the vagina using PCR and denaturing gradient gel electrophoresis (DGGE)
    J P Burton
    The Lawson Health Research Institute, St Joseph s Hospital, London, Ontario, Canada
    Int J Gynaecol Obstet 81:61-3. 2003
  86. pmc Clinical evaluation of affirm VPIII in the detection and identification of Trichomonas vaginalis, Gardnerella vaginalis, and Candida species in vaginitis/vaginosis
    Haywood L Brown
    Department of Obstetrics, Gynecology and Pathology, St Vincent Hospitals and Health Service, Indianapolis, IN, USA
    Infect Dis Obstet Gynecol 12:17-21. 2004
    To compare the Affirm VPIII Microbial Identification Test for detection and identification of Candida species, Gardnerella vaginalis and Trichomonas vaginalis to clinical and microscopic criteria commonly used to diagnose vaginitis.
  87. pmc Vaginal flora morphotypic profiles and assessment of bacterial vaginosis in women at risk for HIV infection
    Beth C Tohill
    Centers for Disease Control and Prevention, National Center for Chronic Disease and Public Health Prevention, Division of Nutrition and Physical Activity, Atlanta, GA 30341, USA
    Infect Dis Obstet Gynecol 12:121-6. 2004
    ..The proposed profiles from the Gram stain reflect the morphotypic categories describing vaginal flora that may enable clearer elucidation of gynecologic and obstetric outcomes in various populations...
  88. pmc Evaluation of the Affirm Ambient Temperature Transport System for the detection and identification of Trichomonas vaginalis, Gardnerella vaginalis, and Candida species from vaginal fluid specimens
    H L Brown
    Department of Obstetrics and Gynecology and Pathology, St Vincent Hospitals and Health Services, Indianapolis, Indiana 46240, USA
    J Clin Microbiol 39:3197-9. 2001
    ..containing the three common organisms causing vaginitis: Trichomonas vaginalis, Candida species, and Gardnerella vaginalis (one of the causative agents of bacterial vaginosis)...
  89. ncbi An altered immunity hypothesis for the development of symptomatic bacterial vaginosis
    Steven S Witkin
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Clin Infect Dis 44:554-7. 2007
    ..A deficit in vaginal mannose-binding lectin concentrations would further decrease the capacity for microbial killing and increase the likelihood of bacterial migration from the vagina to the upper genital tract...
  90. ncbi [Causation and treatment of infectious leucorrhoea at the Cocody University Hospital (Abidjan, Côte d'Ivoire)]
    Raphaël Abauleth
    Service de gynécologie et d obstétrique du CHU de Cocody, B P V 13, Abidjan, Cote d Ivoire
    Sante 16:191-5. 2006
    ..to determine the frequency of different bacteria causing infectious leucorrhoea and to calculate the percentage of cures after standard treatment...
  91. ncbi The International Infections in Pregnancy (IIP) study: variations in the prevalence of bacterial vaginosis and distribution of morphotypes in vaginal smears among pregnant women
    Jorge E Tolosa
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Thomas Jefferson University for The Global Network for Perinatal and Reproductive Health, Philadelphia, PA, USA
    Am J Obstet Gynecol 195:1198-204. 2006
    ..The objective of the study was to determine the prevalence of bacterial vaginosis and the distribution of associated morphotypes among asymptomatic pregnant women in different countries...
  92. ncbi [The bacterial vaginosis--treatment problems]
    Małgorzata K Romanik
    Z Katedry i Zakladu Mikrobiologii Lekarskiej Slaskiej Akademii Medycznej w Katowicach
    Wiad Lek 60:64-7. 2007
    ..and increasing number of Mobiluncus spp., Gardnerella vaginalis, Atopobium vaginae, Prevotella spp., Mycoplasma hominis, Peptostreptococcus spp...
  93. ncbi Symptomatic candidiasis: Using self sampled vaginal smears to establish the presence of Candida, lactobacilli, and Gardnerella vaginalis
    M K Engberts
    Leiden Cytology and Pathology Laboratory, Leiden, The Netherlands
    Diagn Cytopathol 35:635-9. 2007
    ..Thereafter, the smears were restained with Giemsa-stain to determine presence of lactobacilli, Gardnerella vaginalis ("clue cells") and neutrophils...
  94. ncbi Relationship of abnormal vaginal flora, proinflammatory cytokines and idiopathic infertility in women undergoing IVF
    S D Spandorfer
    Center for Reproductive Medicine and Infertility and Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York, USA
    J Reprod Med 46:806-10. 2001
    ..The induction of proinflammatory cytokines by an altered vaginal ecosystem may be a previously unrecognized cause of idiopathic infertility...
  95. ncbi [Protease and phospholipase activities of Candida albicans isolated from vaginal secretions with different pH values]
    Adriana M Ombrella
    Catedra de Microbiologia, Virologia y Parasitologia, Facultad de Ciencias Medicas, Universidad Nacional de Rosario, Argentina
    Rev Iberoam Micol 25:12-6. 2008
    ..0001). Based on these results we postulate that the simultaneous occurrence of bacterial vaginosis and vulvovaginal candidiasis could be related to the proteolytic activity but unrelated to phospholipases activity...
  96. ncbi Atopobium vaginae triggers an innate immune response in an in vitro model of bacterial vaginosis
    Erika K Libby
    Molecular and Cellular Biology Division, Medical Diagnostic Laboratories, LLC 2439 Kuser Rd, Hamilton, NJ 08690, USA
    Microbes Infect 10:439-46. 2008
    ..flora from the predominant Lactobacillus species to other bacterial species such as Atopobium vaginae and Gardnerella vaginalis. This change is associated with an increase in vaginal cytokine secretion...
  97. ncbi Gardnerella vaginalis and Lactobacillus sp in liquid-based cervical samples in healthy and disturbed vaginal flora using cultivation-independent methods
    Johanna M Klomp
    Leiden Cytology and Pathology Laboratory, Leiden, The Netherlands
    Diagn Cytopathol 36:277-84. 2008
    ..DNA of five bacterial species: Lactobacillus acidophilus, Lactobacillus crispatus, Lactobacillus jensenii, Gardnerella vaginalis, and Mycoplasma hominis...
  98. ncbi Longitudinal trajectory of bacterial vaginosis during pregnancy
    Thaddeus P Waters
    Department of Obstetrics and Gynecology, MetroHealth Medical Center, Cleveland, OH, USA
    Am J Obstet Gynecol 199:431.e1-5. 2008
    ..This study was undertaken to characterize the course of bacterial vaginosis in pregnancy and to discern the bacterial morphotypes responsible for infection...
  99. pmc Spermicidal activity of the safe natural antimicrobial peptide subtilosin
    Katia E Sutyak
    Department of Microbiology and Molecular Genetics, Rutgers, The State University of New Jersey, New Brunswick, NJ 08854 8097, USA
    Infect Dis Obstet Gynecol 2008:540758. 2008
    ..BV), a condition affecting millions of women each year, is primarily caused by the gram-variable organism Gardnerella vaginalis. A number of organisms associated with BV cases have been reported to develop multidrug resistance, ..
  100. doi Bacterial vaginosis: a sexually enhanced disease
    Hans Verstraelen
    Int J STD AIDS 19:575-6. 2008
  101. ncbi [Vulvovaginitis: vaginal pH changes and associated microflora]
    Ana Conceição Ribeiro Dantas Saturnino
    Departamento de Análises Clínicas e Toxicológicas da Universidade Federal do Rio Grande do Norte
    Acta Cir Bras 20:266-9. 2005
    ..To establish a correlation between pH vaginal and the microflora associated in carriers of vulvovaginites...

Research Grants23

  1. Bacteriocins inhibiting growth of vaginal lactobacilli
    Vivien Pybus; Fiscal Year: 2004
    ..such that the Lactobacillus-dominated populations present in healthy individuals are replaced by Gardnerella vaginalis, anaerobes, and genital mycoplasmas...
  2. The role of novel, uncultivable bacteria in incident PID
    CATHERINE L contact HAGGERTY; Fiscal Year: 2011
    ..hypothesis that BV-associated bacteria (Bacterial Vaginosis Associated Bacteria 1 (BVAB1), BVAB2, BVAB3, Gardnerella vaginalis, Atopobium vaginae, Eggerthella-like bacterium, Leptotrichia spp...
  3. Gardnerella vaginalis: toxin production and pathogenesis
    ADAM JONATHAN RATNER; Fiscal Year: 2013
    ..We have recently characterized vaginolysin (VLY), a cholesterol-dependent cytolysin from Gardnerella vaginalis (a bacterial species present on the vaginal mucosa in the setting of BV and thought to contribute to the ..
  4. Development of Bacterial Therapeutics Targeting Bacterial Vaginosis-Associated Bi
    Qiang Xu; Fiscal Year: 2010
    ..jensenii with a disrupted pox1 gene in the chromosome that exhibits highly potent activity against a Gardnerella vaginalis strain (ATCC 14018)...
  5. RCT of Treatment of Male Partners of Women with Recurrent Bacterial Vaginosis
    Jane R Schwebke; Fiscal Year: 2012
    ..It is clear that Gardnerella vaginalis plays a role in this syndrome since it is present in high concentrations in all women with BV...
  6. DNase For Prevention Of Reproductive Tract Infections In Pregnancy
    ADAM JONATHAN RATNER; Fiscal Year: 2013
    ..We have found that both Gardnerella vaginalis (the major constituent of the vaginal microbiota during bacterial vaginosis) and group B Streptococcus (..
  7. Impact of suppressive antimicrobial therapy on the vaginal microbiota and BV
    RAYMOND SCOTT MCCLELLAND; Fiscal Year: 2013
    ..effect of PPT on the detection and concentration of BV-associated bacterial species (BVAB1, BVAB2, BVAB3, Gardnerella vaginalis, Atopobium vaginae, Leptotrichia amnionii, and Megasphaera species)...
  8. GU Infection Self-Diagnosis for Deployed Military Women
    Nancy Ryan Wenger; Fiscal Year: 2004
    ..self- diagnoses in comparison with laboratory reference standards (urine culture and DNA probe testing for gardnerella vaginalis, trichomonas vaginalis, and candida species)...
  9. Natural antimicrobials against bacterial vaginosis
    Michael Chikindas; Fiscal Year: 2006
    ..associated with the depletion of lactobacilli, the major flora of a healthy vagina and the overgrowth of Gardnerella vaginalis, Peptostreptococcus spp. and Prevotella bivia. BV may lead to premature labor...
  10. HIV activation in alcohol-aided G. vaginalis virulence
    Abraham Rosenberg; Fiscal Year: 2005
    ..The application proposes to test the novel hypothesis that Gardnerella vaginalis is a major opportunistic HIV co-infection agent for women that features alcohol enhanced activity of its ..
  11. Inflammation and Ovarian Cancer
    Clareann Bunker; Fiscal Year: 2008
    ..In particular, NSAID use may prove to be a potentially important chemopreventative for this often-fatal disease. ..
  12. The Molecular Microbiology of Bacterial Vaginosis
    David Fredricks; Fiscal Year: 2003
    ..In future studies, vaginal fluid samples from a larger cohort of women will be assayed to determine if a candidate pathogen is specifically associated with BV. ..
  13. Quantitative PCR for the Detection of Fungal Infections
    David Fredricks; Fiscal Year: 2008
    ..Hypothesis: Fungal 18S rDNA qPCR employing a broad range fungal probe, or a system of multiple specific probes, will be useful for detecting emerging fungal pathogens in the transplant setting. [unreadable] [unreadable]..
  14. VIOLENCE AND SPONTANEOUS ABORTION IN INNER CITY WOMEN
    Deborah Nelson; Fiscal Year: 2002
    ....
  15. The Acquisition of Bacterial Vaginosis in Lesbians
    Jeanne Marrazzo; Fiscal Year: 2006
    ..Lesbian couples provide a unique opportunity to conduct comparative studies of vaginal microbial ecology in sex partners, and to directly analyze determinants of transmission. ..
  16. EFFECTIVENESS OF OUTPATIENT TREATMENT OF PID
    Roberta Ness; Fiscal Year: 2003
    ..We gain great efficiency in the use of the extensive resources and excellent follow-up success within the PEACH cohort. ..
  17. DOUCHING, VAGINAL MICROBIOLOGY, AND PID
    Roberta Ness; Fiscal Year: 2003
    ..Given the paucity of information regarding the relationship between douching and reproductive outcomes, the proposed study is imperative in order to direct future public health recommendations. ..
  18. Trichomonas Lipophosphoglycan in Regulation Immune Responses
    Raina Fichorova; Fiscal Year: 2008
    ..vaginalis infections and complications. [unreadable] [unreadable] [unreadable]..
  19. QUANTITATIVE MICROBIOLOGIC MODEL FOR PRETERM DELIVERY
    Andrew Onderdonk; Fiscal Year: 2004
    ....
  20. ANTI-HIV-1 ACTIVITY OF MANNAN-BINDING LECTIN
    Gregory Spear; Fiscal Year: 2003
    ..3. Utilize inhibitors of glycosylation to enhance biological effects of MBL. Exarnine the interaction of MBL with anti-viral antibodies in mediating anti-viral effects. Deterrnine the interaction of HIV-1 with MBL in vivo. ..
  21. Gene Polymorphisms, Preterm Birth, Neonatal Complicatio*
    Steven Witkin; Fiscal Year: 2005
    ..Identification of genetic factors in mothers or their neonates that influence susceptibility to preterm labor and fetal morbidity in different racial groups will aid in development of improved protocols for monitoring and treatment...