yersinia pestis

Summary

Summary: The etiologic agent of PLAGUE in man, rats, ground squirrels, and other rodents.

Top Publications

  1. pmc Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity
    Giovanna Morelli
    Max Planck Institut für Infektionsbiologie, Department of Molecular Biology, Berlin, Germany
    Nat Genet 42:1140-3. 2010
  2. pmc A draft genome of Yersinia pestis from victims of the Black Death
    Kirsten I Bos
    McMaster Ancient DNA Centre, Department of Anthropology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8, Canada
    Nature 478:506-10. 2011
  3. ncbi Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response
    Sara W Montminy
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Immunol 7:1066-73. 2006
  4. ncbi CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies
    C Pourcel
    GPMS, Institut de Genetique et Microbiologie, Universite Paris XI, 91405 Orsay Cedex, France
    Microbiology 151:653-63. 2005
  5. pmc Targeted enrichment of ancient pathogens yielding the pPCP1 plasmid of Yersinia pestis from victims of the Black Death
    Verena J Schuenemann
    Institut für Naturwissenschaftliche Archäologie, University of Tubingen, 72072 Tubingen, Germany
    Proc Natl Acad Sci U S A 108:E746-52. 2011
  6. pmc Yersinia pestis--etiologic agent of plague
    R D Perry
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536, USA
    Clin Microbiol Rev 10:35-66. 1997
  7. pmc Phylogeography and molecular epidemiology of Yersinia pestis in Madagascar
    Amy J Vogler
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, USA
    PLoS Negl Trop Dis 5:e1319. 2011
  8. pmc Progression of primary pneumonic plague: a mouse model of infection, pathology, and bacterial transcriptional activity
    Wyndham W Lathem
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:17786-91. 2005
  9. pmc Reliable detection of Bacillus anthracis, Francisella tularensis and Yersinia pestis by using multiplex qPCR including internal controls for nucleic acid extraction and amplification
    Ingmar Janse
    National Institute for Public Health and the Environment, Laboratory for Zoonoses and Environmental Microbiology, Bilthoven, The Netherlands
    BMC Microbiol 10:314. 2010
  10. pmc Modification of the structure and activity of lipid A in Yersinia pestis lipopolysaccharide by growth temperature
    Kazuyoshi Kawahara
    Department of Bacteriology, The Kitasato Institute, Tokyo 108 8642, Japan
    Infect Immun 70:4092-8. 2002

Detail Information

Publications291 found, 100 shown here

  1. pmc Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity
    Giovanna Morelli
    Max Planck Institut für Infektionsbiologie, Department of Molecular Biology, Berlin, Germany
    Nat Genet 42:1140-3. 2010
    Plague is a pandemic human invasive disease caused by the bacterial agent Yersinia pestis. We here report a comparison of 17 whole genomes of Y. pestis isolates from global sources. We also screened a global collection of 286 Y...
  2. pmc A draft genome of Yersinia pestis from victims of the Black Death
    Kirsten I Bos
    McMaster Ancient DNA Centre, Department of Anthropology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8, Canada
    Nature 478:506-10. 2011
    ..Here we report a reconstructed ancient genome of Yersinia pestis at 30-fold average coverage from Black Death victims securely dated to episodes of pestilence-associated ..
  3. ncbi Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response
    Sara W Montminy
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Immunol 7:1066-73. 2006
    At mammalian body temperature, the plague bacillus Yersinia pestis synthesizes lipopolysaccharide (LPS)-lipid A with poor Toll-like receptor 4 (TLR4)-stimulating activity...
  4. ncbi CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies
    C Pourcel
    GPMS, Institut de Genetique et Microbiologie, Universite Paris XI, 91405 Orsay Cedex, France
    Microbiology 151:653-63. 2005
    ..In the Yersinia pestis genome, three such elements are found at three distinct loci, one of them being highly polymorphic...
  5. pmc Targeted enrichment of ancient pathogens yielding the pPCP1 plasmid of Yersinia pestis from victims of the Black Death
    Verena J Schuenemann
    Institut für Naturwissenschaftliche Archäologie, University of Tubingen, 72072 Tubingen, Germany
    Proc Natl Acad Sci U S A 108:E746-52. 2011
    Although investigations of medieval plague victims have identified Yersinia pestis as the putative etiologic agent of the pandemic, methodological limitations have prevented large-scale genomic investigations to evaluate changes in the ..
  6. pmc Yersinia pestis--etiologic agent of plague
    R D Perry
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536, USA
    Clin Microbiol Rev 10:35-66. 1997
    Plague is a widespread zoonotic disease that is caused by Yersinia pestis and has had devastating effects on the human population throughout history...
  7. pmc Phylogeography and molecular epidemiology of Yersinia pestis in Madagascar
    Amy J Vogler
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, USA
    PLoS Negl Trop Dis 5:e1319. 2011
    ..pestis in Madagascar...
  8. pmc Progression of primary pneumonic plague: a mouse model of infection, pathology, and bacterial transcriptional activity
    Wyndham W Lathem
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:17786-91. 2005
    Although pneumonic plague is the deadliest manifestation of disease caused by the bacterium Yersinia pestis, there is surprisingly little information on the cellular and molecular mechanisms responsible for Y...
  9. pmc Reliable detection of Bacillus anthracis, Francisella tularensis and Yersinia pestis by using multiplex qPCR including internal controls for nucleic acid extraction and amplification
    Ingmar Janse
    National Institute for Public Health and the Environment, Laboratory for Zoonoses and Environmental Microbiology, Bilthoven, The Netherlands
    BMC Microbiol 10:314. 2010
    ..To reduce the impact of such highly pathogenic micro-organisms, rapid and accurate diagnostic tools are needed for their detection in various samples, including environmental samples...
  10. pmc Modification of the structure and activity of lipid A in Yersinia pestis lipopolysaccharide by growth temperature
    Kazuyoshi Kawahara
    Department of Bacteriology, The Kitasato Institute, Tokyo 108 8642, Japan
    Infect Immun 70:4092-8. 2002
    b>Yersinia pestis strain Yreka was grown at 27 or 37 degrees C, and the lipid A structures (lipid A-27 degrees C and lipid A-37 degrees C) of the respective lipopolysaccharides (LPS) were investigated by matrix-assisted laser desorption ..
  11. pmc The human-bacterial pathogen protein interaction networks of Bacillus anthracis, Francisella tularensis, and Yersinia pestis
    Matthew D Dyer
    Virginia Bioinformatics Institute, Blacksburg, Virginia, United States of America
    PLoS ONE 5:e12089. 2010
    Bacillus anthracis, Francisella tularensis, and Yersinia pestis are bacterial pathogens that can cause anthrax, lethal acute pneumonic disease, and bubonic plague, respectively, and are listed as NIAID Category A priority pathogens for ..
  12. pmc Global discovery of small RNAs in Yersinia pseudotuberculosis identifies Yersinia-specific small, noncoding RNAs required for virulence
    Jovanka T Koo
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 108:E709-17. 2011
    ..Six sRNAs are Y. pseudotuberculosis specific and are absent from the genome of the closely related species Yersinia pestis. We found that the expression of many sRNAs conserved between Y. pseudotuberculosis and Y...
  13. ncbi Transcriptional profiling of a mice plague model: insights into interaction between Yersinia pestis and its host
    Haihong Liu
    Laboratory of Analytical Microbiology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China
    J Basic Microbiol 49:92-9. 2009
    Despite the importance of pneumonic plague caused by Yersinia pestis, a few is known about the interaction between Y. pestis and its host at the molecular level during the pneumonic plague development...
  14. pmc Intraspecific diversity of Yersinia pestis
    Andrey P Anisimov
    Department of Infectious Diseases, State Research Center for Applied Microbiology, 142279 Obolensk, Serpukhov District, Moscow Region, Russia
    Clin Microbiol Rev 17:434-64. 2004
    Increased interest in the pathogenic potential of Yersinia pestis has emerged because of the potential threats from bioterrorism...
  15. pmc Yersinia pestis caf1 variants and the limits of plague vaccine protection
    Lauriane E Quenee
    Department of Microbiology, University of Chicago, Chicago, Illinois 60637, USA
    Infect Immun 76:2025-36. 2008
    b>Yersinia pestis, the highly virulent agent of plague, is a biological weapon...
  16. pmc Experimental evidence for negative selection in the evolution of a Yersinia pestis pseudogene
    Yi Cheng Sun
    Program in Microbial Pathogenesis, Department of Cell and Tissue Biology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 105:8097-101. 2008
    b>Yersinia pestis, the agent of bubonic plague, evolved from the enteric pathogen Yersinia pseudotuberculosis within the past 20,000 years...
  17. pmc Plague: past, present, and future
    Nils Chr Stenseth
    Centre for Ecological and Evolutionary Synthesis, Department of Biology, University of Oslo, Oslo, Norway
    PLoS Med 5:e3. 2008
  18. pmc Role of the Yersinia pestis plasminogen activator in the incidence of distinct septicemic and bubonic forms of flea-borne plague
    Florent Sebbane
    Laboratory of Zoonotic Pathogens and Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 103:5526-30. 2006
    b>Yersinia pestis is transmitted by fleas and causes bubonic plague, characterized by severe local lymphadenitis that progresses rapidly to systemic infection and life-threatening septicemia...
  19. pmc Insight into microevolution of Yersinia pestis by clustered regularly interspaced short palindromic repeats
    Yujun Cui
    State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, China
    PLoS ONE 3:e2652. 2008
    b>Yersinia pestis, the pathogen of plague, has greatly influenced human history on a global scale...
  20. ncbi Poor vector competence of fleas and the evolution of hypervirulence in Yersinia pestis
    Ellen A Lorange
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Infect Dis 191:1907-12. 2005
    ..Yersinia species have indicated that arthropodborne transmission is an evolutionarily recent adaptation in Yersinia pestis, the agent of plague. We show that the infectivity of Y...
  21. pmc RovA, a global regulator of Yersinia pestis, specifically required for bubonic plague
    Jason S Cathelyn
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:13514-9. 2006
    ..Here, we show the involvement of RovA in the virulence of Yersinia pestis, which naturally lacks a functional inv gene. A Y...
  22. pmc Distinct CCR2(+) Gr1(+) cells control growth of the Yersinia pestis ΔyopM mutant in liver and spleen during systemic plague
    Zhan Ye
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536 0298, USA
    Infect Immun 79:674-87. 2011
    ..to identify the cells and pathways that are undermined by the virulence protein YopM of the plague bacterium Yersinia pestis. In this study, we pursued previous findings that Gr1(+) cells are required to selectively limit growth of Δ..
  23. pmc Imaging of bubonic plague dynamics by in vivo tracking of bioluminescent Yersinia pestis
    Toan Nham
    Yersinia Research Unit, Institut Pasteur, Paris, France
    PLoS ONE 7:e34714. 2012
    b>Yersinia pestis dissemination in a host is usually studied by enumerating bacteria in the tissues of animals sacrificed at different times...
  24. ncbi Microarray expression profiling of Yersinia pestis in response to chloramphenicol
    Jingfu Qiu
    Laboratory of Analytical Microbiology, State Key Laboratory of Pathogen and Biosecurity, National Center for Biomedical Analysis, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China
    FEMS Microbiol Lett 263:26-31. 2006
    Plague is a deadly disease caused by Yersinia pestis. Human plague can be effectively controlled by timely antibiotic administration, chloramphenicol being a drug of choice...
  25. pmc Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation
    Paul A Price
    Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 109:3083-8. 2012
    ..In a coinfection model of pneumonic plague, it appears that Yersinia pestis quickly creates a localized, dominant anti-inflammatory state that allows for the survival and rapid growth ..
  26. ncbi Fibrin and fibrinolysis in infection and host defense
    J L Degen
    Division of Developmental Biology, Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Thromb Haemost 5:24-31. 2007
    ..activation to the evasion of the inflammatory response is particularly conspicuous with the plague agent, Yersinia pestis. Infection of control mice with wild-type Y...
  27. pmc Transcriptomic and innate immune responses to Yersinia pestis in the lymph node during bubonic plague
    Jason E Comer
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 78:5086-98. 2010
    A delayed inflammatory response is a prominent feature of infection with Yersinia pestis, the agent of bubonic and pneumonic plague...
  28. pmc High throughput, multiplexed pathogen detection authenticates plague waves in medieval Venice, Italy
    Thi Nguyen Ny Tran
    Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS 6236 IRD 198, IFR48, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    PLoS ONE 6:e16735. 2011
    ..Historical records suggest that multiple burial sites from the 14th-16th centuries in Venice, Italy, were used during the Black Death and subsequent plague epidemics...
  29. pmc Adaptive response of Yersinia pestis to extracellular effectors of innate immunity during bubonic plague
    Florent Sebbane
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 103:11766-71. 2006
    b>Yersinia pestis causes bubonic plague, characterized by an enlarged, painful lymph node, termed a bubo, that develops after bacterial dissemination from a fleabite site...
  30. pmc Global gene expression profiling of Yersinia pestis replicating inside macrophages reveals the roles of a putative stress-induced operon in regulating type III secretion and intracellular cell division
    Hana S Fukuto
    Center for Infectious Diseases, Department of Molecular Genetics and Biology, Stony Brook University, Stony Brook, NY 11794 5120, USA
    Infect Immun 78:3700-15. 2010
    b>Yersinia pestis, the causative agent of plague, is a facultative intracellular pathogen. Previous studies have indicated that the ability of Y...
  31. pmc Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis
    Alexander G Bobrov
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY, USA
    Mol Microbiol 79:533-51. 2011
    ..we systematically examine the functionality of the genes encoding putative c-di-GMP metabolic enzymes in Yersinia pestis. We determine that, in addition to hmsT and hmsP, only the gene y3730 encodes a functional enzyme capable of ..
  32. pmc The NlpD lipoprotein is a novel Yersinia pestis virulence factor essential for the development of plague
    Avital Tidhar
    Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona, Israel
    PLoS ONE 4:e7023. 2009
    b>Yersinia pestis is the causative agent of plague. Previously we have isolated an attenuated Y. pestis transposon insertion mutant in which the pcm gene was disrupted...
  33. pmc Immunization with recombinant V10 protects cynomolgus macaques from lethal pneumonic plague
    Claire A Cornelius
    Department of Microbiology, University of Chicago, Chicago, Illinois 60637, USA
    Infect Immun 76:5588-97. 2008
    Vaccine and therapeutic strategies that prevent infections with Yersinia pestis have been sought for over a century...
  34. pmc Ail binding to fibronectin facilitates Yersinia pestis binding to host cells and Yop delivery
    Tiffany M Tsang
    Department of Microbiology and Immunology, University of Michigan School of Medicine, 1011 N University, Ann Arbor, MI 48109 1078, USA
    Infect Immun 78:3358-68. 2010
    b>Yersinia pestis, the causative agent of plague, evades host immune responses and rapidly causes disease. The Y. pestis adhesin Ail mediates host cell binding and is critical for Yop delivery...
  35. pmc Yersinia pestis biofilm in the flea vector and its role in the transmission of plague
    B J Hinnebusch
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIH, NIAID, Hamilton, MT 59840, USA
    Curr Top Microbiol Immunol 322:229-48. 2008
    Transmission by fleabite is a relatively recent evolutionary adaptation of Yersinia pestis, the bacterial agent of bubonic plague. To produce a transmissible infection, Y...
  36. pmc Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis
    R William DePaolo
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Cell Host Microbe 4:350-61. 2008
    ..b>Yersinia pestis virulence factor LcrV is reported to induce IL-10 production via interaction with Toll-like receptor (TLR) 2...
  37. pmc Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals new insights into the evolution and pangenome of the plague bacterium
    Mark Eppinger
    Institute for Genome Sciences and Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    J Bacteriol 192:1685-99. 2010
    To gain insights into the origin and genome evolution of the plague bacterium Yersinia pestis, we have sequenced the deep-rooted strain Angola, a virulent Pestoides isolate...
  38. pmc Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
    M Achtman
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 96:14043-8. 1999
    Plague, one of the most devastating diseases of human history, is caused by Yersinia pestis. In this study, we analyzed the population genetic structure of Y. pestis and the two other pathogenic Yersinia species, Y...
  39. pmc Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1-capsule-positive and -negative strains of Yersinia pestis
    G W Anderson
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Infect Immun 64:4580-5. 1996
    The purified recombinant V antigen from Yersinia pestis, expressed in Escherichia coli and adsorbed to aluminum hydroxide, an adjuvant approved for human use, was used to immunize outbred Hsd:ND4 mice subcutaneously...
  40. pmc Innate immune response during Yersinia infection: critical modulation of cell death mechanisms through phagocyte activation
    Tessa Bergsbaken
    Department of Microbiology, University of Washington, Seattle, WA, USA
    J Leukoc Biol 86:1153-8. 2009
    b>Yersinia pestis, the etiological agent of plague, is one of the most deadly pathogens on our planet...
  41. pmc Immune defense against pneumonic plague
    Stephen T Smiley
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Rev 225:256-71. 2008
    b>Yersinia pestis is one of the world's most virulent human pathogens. Inhalation of this Gram-negative bacterium causes pneumonic plague, a rapidly progressing and usually fatal disease. Extensively antibiotic-resistant strains of Y...
  42. pmc Yersinia pestis two-component gene regulatory systems promote survival in human neutrophils
    Jason L O'Loughlin
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Infect Immun 78:773-82. 2010
    ..Pathogens such as Yersinia pestis resist destruction by the innate immune system and are able to survive in macrophages and neutrophils...
  43. ncbi The RovA regulons of Yersinia enterocolitica and Yersinia pestis are distinct: evidence that many RovA-regulated genes were acquired more recently than the core genome
    Jason S Cathelyn
    Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Ave, Saint Louis, MO 63110, USA
    Mol Microbiol 66:189-205. 2007
    ..This repression can be selectively relieved by regulators such as RovA, and the observation that nearly all RovA-activated genes are repressed by H-NS is consistent with this model...
  44. ncbi Temperature and growth phase influence the outer-membrane proteome and the expression of a type VI secretion system in Yersinia pestis
    Rembert Pieper
    J Craig Venter Institute, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Microbiology 155:498-512. 2009
    b>Yersinia pestis cells were grown in vitro at 26 and 37 degrees C, the ambient temperatures of its flea vector and its mammalian hosts, respectively, and subjected to subcellular fractionation...
  45. ncbi An active site water network in the plasminogen activator pla from Yersinia pestis
    Elif Eren
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Structure 18:809-18. 2010
    The plasminogen activator Pla from Yersinia pestis is an outer membrane protease (omptin) that is important for the virulence of plague. Here, we present the high-resolution crystal structure of wild-type, enzymatically active Pla at 1...
  46. pmc Involvement of the post-transcriptional regulator Hfq in Yersinia pestis virulence
    Jing Geng
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
    PLoS ONE 4:e6213. 2009
    b>Yersinia pestis is the causative agent of plague, which is transmitted primarily between fleas and mammals and is spread to humans through the bite of an infected flea or contact with afflicted animals...
  47. ncbi Susceptibility to Yersinia pestis experimental infection in wild Rattus rattus, reservoir of plague in Madagascar
    C Tollenaere
    IRD, UMR CBGP INRA IRD Cirad Montpellier SupAgro, Campus International de Baillarguet, CS 30016, 34988 Montferrier sur Lez Cedex, France
    Ecohealth 7:242-7. 2010
    In Madagascar, the black rat, Rattus rattus, is the main reservoir of plague (Yersinia pestis infection), a disease still responsible for hundreds of cases each year in this country...
  48. pmc Kinetics of disease progression and host response in a rat model of bubonic plague
    Florent Sebbane
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Am J Pathol 166:1427-39. 2005
    Plague, caused by the gram-negative bacterium Yersinia pestis, primarily affects rodents but is also an important zoonotic disease of humans...
  49. ncbi Lack of O-antigen is essential for plasminogen activation by Yersinia pestis and Salmonella enterica
    Maini Kukkonen
    Division of General Microbiology, Department of Biosciences, FIN 00014 University of Helsinki, Helsinki, Finland
    Mol Microbiol 51:215-25. 2004
    ..virulence factor in enterobacterial infections, and the advantage of its genetic loss in the lethal pathogen Yersinia pestis has remained unresolved. Y...
  50. pmc TNFα and IFNγ contribute to F1/LcrV-targeted immune defense in mouse models of fully virulent pneumonic plague
    Jr Shiuan Lin
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Vaccine 29:357-62. 2010
    Immunization with the Yersinia pestis F1 and LcrV proteins improves survival in mouse and non-human primate models of pneumonic plague...
  51. pmc The NLRP12 inflammasome recognizes Yersinia pestis
    Gregory I Vladimer
    Division of Infectious Diseases and Immunology, UMass Medical School, Worcester, MA 01605, USA
    Immunity 37:96-107. 2012
    b>Yersinia pestis, the causative agent of plague, is able to suppress production of inflammatory cytokines IL-18 and IL-1β, which are generated through caspase-1-activating nucleotide-binding domain and leucine-rich repeat (NLR)-..
  52. pmc Humans and evolutionary and ecological forces shaped the phylogeography of recently emerged diseases
    PAUL S KEIM
    The Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ 86011 4073, USA
    Nat Rev Microbiol 7:813-21. 2009
    ..This Review describes the distributions of the bacteria that cause anthrax, plague and tularaemia and investigates the forces that created clonal structures in these species...
  53. pmc Role of the Yersinia pestis yersiniabactin iron acquisition system in the incidence of flea-borne plague
    Florent Sebbane
    Equipe Peste et Yersinia pestis, Centre d Infection et d Immunité de Lille, Institut Pasteur de Lille, Lille, France
    PLoS ONE 5:e14379. 2010
    Plague is a flea-borne zoonosis caused by the bacterium Yersinia pestis. Y...
  54. ncbi Translocation of YopE and YopN into eukaryotic cells by Yersinia pestis yopN, tyeA, sycN, yscB and lcrG deletion mutants measured using a phosphorylatable peptide tag and phosphospecific antibodies
    James B Day
    Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33101, USA
    Mol Microbiol 47:807-23. 2003
    b>Yersinia pestis, the causative agent of plague, exports a set of virulence proteins called Yops upon contact with eukaryotic cells. A subset of these Yops is translocated directly into the cytosol of host cells...
  55. pmc Plague and climate: scales matter
    Tamara Ben-Ari
    Centre for Ecological and Evolutionary Synthesis CEES, University of Oslo, Oslo, Norway
    PLoS Pathog 7:e1002160. 2011
    ..Its causative agent Yersinia pestis relies on wild rodent hosts and flea vectors for its maintenance in nature...
  56. pmc Structural insights into Ail-mediated adhesion in Yersinia pestis
    Satoshi Yamashita
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 8030, USA
    Structure 19:1672-82. 2011
    Ail is an outer membrane protein from Yersinia pestis that is highly expressed in a rodent model of bubonic plague, making it a good candidate for vaccine development...
  57. ncbi Early systemic bacterial dissemination and a rapid innate immune response characterize genetic resistance to plague of SEG mice
    Christian E Demeure
    Yersinia Research Unit, Institut Pasteur, Paris, France
    J Infect Dis 205:134-43. 2012
    Although laboratory mice are usually highly susceptible to Yersinia pestis, we recently identified a mouse strain (SEG) that exhibited an exceptional capacity to resist bubonic plague and used it to identify immune mechanisms associated ..
  58. pmc Historical variations in mutation rate in an epidemic pathogen, Yersinia pestis
    Yujun Cui
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China
    Proc Natl Acad Sci U S A 110:577-82. 2013
    The genetic diversity of Yersinia pestis, the etiologic agent of plague, is extremely limited because of its recent origin coupled with a slow clock rate. Here we identified 2,326 SNPs from 133 genomes of Y...
  59. pmc Structural basis for activation of an integral membrane protease by lipopolysaccharide
    Elif Eren
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 287:23971-6. 2012
    ..The plasminogen activator (Pla) of Yersinia pestis is an omptin family member that is very important for development of both bubonic and pneumonic plague...
  60. pmc Molecular characterization of transcriptional regulation of rovA by PhoP and RovA in Yersinia pestis
    Yiquan Zhang
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People s Republic of China
    PLoS ONE 6:e25484. 2011
    b>Yersinia pestis is the causative agent of plague. The two transcriptional regulators, PhoP and RovA, are required for the virulence of Y. pestis through the regulation of various virulence-associated loci...
  61. ncbi The phosphodiesterase activity of the HmsP EAL domain is required for negative regulation of biofilm formation in Yersinia pestis
    Alexander G Bobrov
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536 0298, USA
    FEMS Microbiol Lett 247:123-30. 2005
    In Yersinia pestis, biofilm formation is stimulated by HmsT, a GGDEF-domain containing protein that synthesizes cyclic-di-GMP (c-di-GMP), and inhibited by HmsP, an EAL-domain protein...
  62. pmc An experimentally-supported genome-scale metabolic network reconstruction for Yersinia pestis CO92
    Pep Charusanti
    Department of Bioengineering, University of California, San Diego, La Jolla, California, USA
    BMC Syst Biol 5:163. 2011
    b>Yersinia pestis is a gram-negative bacterium that causes plague, a disease linked historically to the Black Death in Europe during the Middle Ages and to several outbreaks during the modern era. Metabolism in Y...
  63. pmc Genotyping, Orientalis-like Yersinia pestis, and plague pandemics
    Michel Drancourt
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 10:1585-92. 2004
    Three pandemics have been attributed to plague in the last 1,500 years. Yersinia pestis caused the third, and its DNA was found in human remains from the second. The Antiqua biovar of Y...
  64. ncbi Genome sequence of Yersinia pestis, the causative agent of plague
    J Parkhill
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 413:523-7. 2001
    The Gram-negative bacterium Yersinia pestis is the causative agent of the systemic invasive infectious disease classically referred to as plague, and has been responsible for three human pandemics: the Justinian plague (sixth to eighth ..
  65. pmc IL-17 contributes to cell-mediated defense against pulmonary Yersinia pestis infection
    Jr Shiuan Lin
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 186:1675-84. 2011
    Pneumonic plague is one of the world's most deadly infectious diseases. The causative bacterium, Yersinia pestis, has the potential to be exploited as a biological weapon, and no vaccine is available...
  66. pmc Novel genetic tools for diaminopimelic acid selection in virulence studies of Yersinia pestis
    David M Bland
    Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, United States of America
    PLoS ONE 6:e17352. 2011
    ..For highly pathogenic bacteria, such as Yersinia pestis, these studies are currently limited because deliberate introduction of antibiotic resistance is restricted ..
  67. ncbi Characterizing the dynamic nature of the Yersinia pestis periplasmic proteome in response to nutrient exhaustion and temperature change
    Rembert Pieper
    J Craig Venter Institute, Rockville, MD 20850, USA
    Proteomics 8:1442-58. 2008
    The periplasmic proteome of Yersinia pestis strain KIM6+ was characterized using differential 2-DE display of proteins isolated from several subcellular fractions...
  68. pmc A live attenuated strain of Yersinia pestis KIM as a vaccine against plague
    Wei Sun
    Center for Infectious Disease and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
    Vaccine 29:2986-98. 2011
    b>Yersinia pestis, the causative agent of plague, is a potential weapon of bioterrorism. Y...
  69. pmc Role of the Yersinia pestis Ail protein in preventing a protective polymorphonuclear leukocyte response during bubonic plague
    B Joseph Hinnebusch
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 79:4984-9. 2011
    The ability of Yersinia pestis to forestall the mammalian innate immune response is a fundamental aspect of plague pathogenesis. In this study, we examined the effect of Ail, a 17-kDa outer membrane protein that protects Y...
  70. pmc Current trends in plague research: from genomics to virulence
    Xiao Zhe Huang
    Division of Communicable Immunology, Department of Bacterial Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Clin Med Res 4:189-99. 2006
    b>Yersinia pestis is the causative agent of plague, which diverged from Yersinia pseudotuberculosis within the past 20,000 years...
  71. pmc Development and comparison of two assay formats for parallel detection of four biothreat pathogens by using suspension microarrays
    Ingmar Janse
    Laboratory for Zoonoses and Environmental Microbiology, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    PLoS ONE 7:e31958. 2012
    ..suspension microarrays for sensitive and specific detection of the biothreat pathogens Bacillus anthracis, Yersinia pestis, Francisella tularensis and Coxiella burnetii...
  72. pmc Proteomic analysis of iron acquisition, metabolic and regulatory responses of Yersinia pestis to iron starvation
    Rembert Pieper
    J Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA
    BMC Microbiol 10:30. 2010
    The Gram-negative bacterium Yersinia pestis is the causative agent of the bubonic plague. Efficient iron acquisition systems are critical to the ability of Y...
  73. pmc The dependence of the Yersinia pestis capsule on pathogenesis is influenced by the mouse background
    Eric H Weening
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
    Infect Immun 79:644-52. 2011
    b>Yersinia pestis is a highly pathogenic Gram-negative organism and the causative agent of bubonic and pneumonic plague. Y...
  74. pmc Influence of Na(+), dicarboxylic amino acids, and pH in modulating the low-calcium response of Yersinia pestis
    Robert R Brubaker
    Department of Microbiology and Molecular Genetics, 2209 Biophysical Medical Sciences Building, Michigan State University, East Lansing, MI 48824, USA
    Infect Immun 73:4743-52. 2005
    The virulence of yersiniae is promoted in part by shared approximately 70-kb plasmids (pCD in Yersinia pestis and pYV in enteropathogenic Yersinia pseudotuberculosis and Yersinia enterocolitica) that mediate a low-calcium response...
  75. pmc Distinct clones of Yersinia pestis caused the black death
    Stephanie Haensch
    Institute for Anthropology, Johannes Gutenberg University, Mainz, Germany
    PLoS Pathog 6:e1001134. 2010
    ..ranging from claims based on genetics and the historical descriptions of symptoms that it was caused by Yersinia pestis to conclusions that it must have been caused by other pathogens...
  76. ncbi A rapid multiplex assay for nucleic acid-based diagnostics
    Alina Deshpande
    Decision Applications Division, Mail Stop K551, Los Alamos National Laboratory, Los Alamos, NM 87545, United States
    J Microbiol Methods 80:155-63. 2010
    ..anthracis, Y. pestis, and F. tularensis. Combined with the ease and robustness of this assay, the results presented here show a strong potential of our assay for use in diagnostics and surveillance...
  77. ncbi Plague
    E D Williamson
    Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wilts SP4 0JQ, UK
    Vaccine 27:D56-60. 2009
    ..This paper reviews the progress towards an improved vaccine for plague and assesses the likely impact of a prophylactic vaccine for bubonic and pneumonic plague...
  78. pmc MLVA distribution characteristics of Yersinia pestis in China and the correlation analysis
    Xiaoai Zhang
    National Institute for Communicable Disease Control and Prevention, and State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Changping, Beijing 102206, PR China
    BMC Microbiol 9:205. 2009
    b>Yersinia pestis, the aetiological agent of plague, has been well defined genotypically on local and worldwide scales...
  79. pmc Caspase-12 and the inflammatory response to Yersinia pestis
    Bart Ferwerda
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 4:e6870. 2009
    ..In African-Americans, it has been shown that caspase-12 inhibits the pro-inflammatory cytokine production...
  80. pmc Plasminogen activator Pla of Yersinia pestis utilizes murine DEC-205 (CD205) as a receptor to promote dissemination
    Shu sheng Zhang
    Department of Biomedical Sciences, College of Medicine Rockford, University of Illinois at Chicago, Rockford, Illinois 61107, USA
    J Biol Chem 283:31511-21. 2008
    b>Yersinia pestis, a Gram-negative bacterium that causes bubonic and pneumonic plague, is able to rapidly disseminate to other parts of its mammalian hosts. Y...
  81. ncbi Environmental monitoring for biological threat agents using the autonomous pathogen detection system with multiplexed polymerase chain reaction
    John F Regan
    Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, California 94550, USA
    Anal Chem 80:7422-9. 2008
    ..During laboratory testing, we evaluated the APDS instrument's response to Bacillus anthracis and Yersinia pestis by spiking the liquid sample stream with viable spores and cells, bead-beaten lysates, and purified DNA ..
  82. pmc YopK regulates the Yersinia pestis type III secretion system from within host cells
    Rebecca Dewoody
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Mol Microbiol 79:1445-61. 2011
    ..These results suggest a novel role for YopK in controlling the Yersinia type III secretion system...
  83. pmc Biogenesis of the fraction 1 capsule and analysis of the ultrastructure of Yersinia pestis
    Lisa M Runco
    Center for Infectious Diseases, Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794 512, USA
    J Bacteriol 190:3381-5. 2008
    Analysis of a Yersinia pestis Delta caf1A mutant demonstrated that the Caf1A usher is required for the assembly and secretion of the fraction 1 capsule...
  84. ncbi A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis
    Feng Shao
    Department of Biological Chemistry, Medical School and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 109:575-88. 2002
    ..These findings provide new insights into mechanisms of animal and plant pathogenesis...
  85. pmc Periplasmic location of the pesticin immunity protein suggests inactivation of pesticin in the periplasm
    H Pilsl
    Mikrobiologie II, Universitat Tubingen, Germany
    J Bacteriol 178:2431-5. 1996
    The pesticin activity and immunity genes on plasmid pPCP1 of Yersinia pestis were sequenced. They encoded proteins of 40 kDa (pesticin) and 16 kDa (immunity protein); the latter was found in the periplasm...
  86. pmc The response regulator PhoP negatively regulates Yersinia pseudotuberculosis and Yersinia pestis biofilms
    Yi Cheng Sun
    Department of Cell and Tissue Biology, Program in Microbial Pathogenesis, University of California, San Francisco, CA, USA
    FEMS Microbiol Lett 290:85-90. 2009
    ..elegans, deletion of phoP was sufficient to produce robust biofilms. In Yersinia pestis, a phoP mutant made more extensive biofilms in vitro than did the wild type...
  87. ncbi The abundance threshold for plague as a critical percolation phenomenon
    S Davis
    Theoretical Epidemiology, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 7, 3584 CL Utrecht, The Netherlands
    Nature 454:634-7. 2008
    ..Archived records of plague (infection with Yersinia pestis) in populations of great gerbils (Rhombomys opimus) in Kazakhstan have been used to show that epizootics only ..
  88. pmc Oligomerization of PcrV and LcrV, protective antigens of Pseudomonas aeruginosa and Yersinia pestis
    Caroline Gebus
    Laboratoire de Biochimie et Biophysique des Systèmes Intégrés Unité mixte de recherche 5092, CNRS, Universite Joseph Fourier, Commissariat a l Energie Atomique, DSV, iRTSV, 17 rue des Martyrs, Grenoble, France
    J Biol Chem 283:23940-9. 2008
    Protective antigens of Pseudomonas aeruginosa (PcrV) and Yersinia pestis (LcrV) are key elements of specialized machinery, the type III secretion system (T3SS), which enables the injection of effector molecules into eukaryotic cells...
  89. ncbi Herpesvirus latency confers symbiotic protection from bacterial infection
    Erik S Barton
    Departments of Pathology and Immunology, Washington University Medical School, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 447:326-9. 2007
    ..respectively, are resistant to infection with the bacterial pathogens Listeria monocytogenes and Yersinia pestis. Latency-induced protection is not antigen specific but involves prolonged production of the antiviral ..
  90. pmc Molecular characterization of the hemin uptake locus (hmu) from Yersinia pestis and analysis of hmu mutants for hemin and hemoprotein utilization
    J M Thompson
    Department of Microbiology and Immunology, University of Kentucky, Lexington, Kentucky 40536 0084, USA
    Infect Immun 67:3879-92. 1999
    Sequence analysis of the hemin uptake locus (hmu) of Yersinia pestis revealed five genes, hmuRSTUV, required for use of hemin and hemoproteins as iron sources...
  91. pmc Vibrio cholerae O139 multiple-drug resistance mediated by Yersinia pestis pIP1202-like conjugative plasmids
    Jing Cao Pan
    Microbiology Laboratory, Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang, People s Republic of China
    Antimicrob Agents Chemother 52:3829-36. 2008
    ..sequences covering 15 backbone regions, the plasmid is most similar to pIP1202, an IncA/C plasmid in an MDR Yersinia pestis isolate from a Madagascar bubonic plague patient, at an identity of 99.99% (22,180/22,183 nucleotides)...
  92. pmc Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV
    Kristin L Debord
    Department of Microbiology, University of Chicago, 920 E 58th Street, Chicago, Illinois 60637, USA
    Infect Immun 74:4910-4. 2006
    In contrast to Yersinia pestis LcrV, the recombinant V10 (rV10) variant (lacking residues 271 to 300) does not suppress the release of proinflammatory cytokines by immune cells...
  93. pmc Pneumonic plague pathogenesis and immunity in Brown Norway rats
    Deborah M Anderson
    Department of Veterinary Pathobiology, University of Missouri, 302 Connaway Hall, 1600 E Rollins St, Columbia, MO 65211, USA
    Am J Pathol 174:910-21. 2009
    ..Thus, the Brown Norway rat is an appealing alternative small animal model for the study of pneumonic plague pathogenesis and immunity...
  94. pmc Intraspecies and temperature-dependent variations in susceptibility of Yersinia pestis to the bactericidal action of serum and to polymyxin B
    Andrey P Anisimov
    State Research Center for Applied Microbiology, Obolensk, Moscow Region 142279, Russia
    Infect Immun 73:7324-31. 2005
    ..Cultivation of different subspecies strains of Yersinia pestis isolated from unrelated geographic origins at various temperatures (mammals, 37 degrees C; fleas, 25 degrees ..
  95. pmc LcrV plague vaccine with altered immunomodulatory properties
    Katie A Overheim
    Department of Microbiology, University of Chicago, CLSC607B, 920 East 58th Street, Chicago, IL 60637, USA
    Infect Immun 73:5152-9. 2005
    b>Yersinia pestis, the causative agent of plague, secretes LcrV (low-calcium-response V or V antigen) during infection...
  96. pmc The cyclic AMP receptor protein, CRP, is required for both virulence and expression of the minimal CRP regulon in Yersinia pestis biovar microtus
    Lingjun Zhan
    Institute of Laboratory Animal Sciences, Chinese Academy of Medicine Peking Union Medical College, Beijing 100021, China
    Infect Immun 76:5028-37. 2008
    ..In the present study, a null deletion of the crp gene was constructed for Yersinia pestis bv. microtus strain 201. Microarray expression analysis disclosed that at least 6% of Y...
  97. ncbi A horizontally acquired filamentous phage contributes to the pathogenicity of the plague bacillus
    Anne Derbise
    Yersinia Research Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 63:1145-57. 2007
    b>Yersinia pestis, the plague bacillus, has an exceptional pathogenicity but the factors responsible for its extreme virulence are still unknown...
  98. ncbi Structure and biogenesis of the capsular F1 antigen from Yersinia pestis: preserved folding energy drives fiber formation
    Anton V Zavialov
    Department of Molecular Biosciences Structural Biology, Uppsala Biomedical Center, Swedish University of Agricultural Sciences, Box 590, SE 751 24 Uppsala, Sweden
    Cell 113:587-96. 2003
    ..The F1 capsular antigen from the plague pathogen Yersinia pestis consists of linear fibers of a single subunit (Caf1) and serves as a prototype for nonpilus organelles ..
  99. ncbi Estimation of vector infectivity rates for plague by means of a standard curve-based competitive polymerase chain reaction method to quantify Yersinia pestis in fleas
    B J Hinnebusch
    Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Am J Trop Med Hyg 58:562-9. 1998
    ..In the case of bubonic plague, infective flea vectors contain large numbers of Yersinia pestis within a bacterial mass that blocks the flea's foregut, and only such blocked fleas are important for ..
  100. pmc Yersinia pestis Orientalis in remains of ancient plague patients
    Michel Drancourt
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 13:332-3. 2007
    b>Yersinia pestis DNA was recently detected in human remains from 2 ancient plague pandemics in France and Germany. We have now sequenced Y pestis glpD gene in such remains, showing a 93-bp deletion specific for biotype Orientalis...
  101. pmc Single-dose, virus-vectored vaccine protection against Yersinia pestis challenge: CD4+ cells are required at the time of challenge for optimal protection
    Anasuya Chattopadhyay
    Department of Pathology, Yale University School of Medicine, 310 Cedar Street LH 315, New Haven, CT 06510, USA
    Vaccine 26:6329-37. 2008
    ..recombinant vesicular stomatitis virus (VSV) vectored plague vaccine expressing a secreted form of Yersinia pestis low calcium response protein V (LcrV) from the first position of the VSV genome...

Research Grants78

  1. Characterization of Hemolysin A from Proteus mirabilis
    Todd Weaver; Fiscal Year: 2004
    ..including the Ca2+-independent cytolysins/hemolyins from Serratia marcescens, Edwardsiella tarda, Yersinia pestis and Proteus mirabilis. HpmA is secreted and activated by HpmB allowing Proteus to lyse red blood cells...
  2. Lung Injury and Shock Pathogenesis in Y. pestis Sepsis
    ANDREW LECHNER; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Yersinia pestis is the causative agent of plague, a pandemic clinically divided into bubonic, septicemic, and pneumonic diseases...
  3. Rapid Detection and Identification of Zoonotic Pathogens
    John Dunn; Fiscal Year: 2007
    ..We plan to use Borrelia burgdorferi, the arthropod-borne etiologic agent of Lyme disease and Yersinia pestis, the etiologic agent of plague, as our principle test agents to work through the systems...
  4. Optimization of Neoglycoside Antibiotics for Nosocomial Pathogens and Select Agen
    Arnold Louie; Fiscal Year: 2013
    ..Resistance has also been defined in Select Agents, such as aminoglycoside resistance in Yersinia pestis in Madagascar. Achaogen has developed several series of new aminoglycoside antibiotics (neoglycosides)...
  5. Analogs of GTP as novel inhibitors of bacterial c-di-GMP-synthesizing enzymes
    George E Wright; Fiscal Year: 2010
    ..plays an essential role in the regulation of biofilm formation of important pathogens as Vibrio cholerae, Yersinia pestis, P. aeruginosa, E. coli, S. enteric and S. aureus...
  6. Inhibitors of the Y. pestis cell surface plasminogen activator for biodefense
    Marjorie H Barnes; Fiscal Year: 2010
    b>Yersinia pestis is a Gram-negative bacillus, which is the etiological agent of plague. Human infection by this pathogen may occur by subcutaneous (e.g...
  7. Rapid point-of-care diagnostic for bioterrorism "A" agents and Pandemic influenza
    Kelly J Henrickson; Fiscal Year: 2010
    ..potential threat (Category "A" agents) include Variola major (smallpox), Bacillus anthracis (anthrax), Yersinia pestis (plague), Clostridium botulinum toxin (botulism), Francisella tularensis (tularaemia), and a group of RNA ..
  8. Defining the functions of uncharacterized genes in priority pathogens
    Sean Crosson; Fiscal Year: 2013
    ..and physiological functions of 235 uncharacterized genes in NIAID Category A (Bacillus anthracis and Yersinia pestis) and Category B (Brucella abortus and Coxiella burnetii) priority pathogens...
  9. Structures of RNA processing and Silencing Enzymes in Prokaryotes
    Hong Li; Fiscal Year: 2013
    ..CRISPR elements are found in medically important bacteria that include but not limited to Yersinia pestis, Mycobacterium tuberculosis, Haemophilus influenzae, Helicobacter pylori, Neisseria meningitides, Vibrio ..
  10. A. L. lactis-based vaccine for children with broad spectrum for enteric pathogens
    Wendy L Picking; Fiscal Year: 2013
    ..Preliminary studies evaluating GEM particles displaying Yersinia pestis LcrV showed that they are highly immunogenic and confer full protection against lethal bacterial infection in ..
  11. Plague biofilm formation--regulation and function
    ROBERT DONALD PERRY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Yersinia pestis is the causative agent of plague which has caused widespread loss of human life during recurrent pandemics...
  12. Novel anti-toxin compounds against Yersinia infections
    Maurizio Pellecchia; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Yersinia pestis is the infectious agent of bubonic plague, however it can also cause pneumonic and septicemic plague...
  13. HTS assay development targeting Yersinia pestis topoisomerase I
    Yuk Ching Tse-Dinh; Fiscal Year: 2011
    ..The lack of drugs in the pipeline for gram-negative bacteria is especially critical. Yersinia pestis is the causative agent for plague, and multi-drug resistant Y...
  14. Structure and mechanism of CRISPR interference.
    Ailong Ke; Fiscal Year: 2013
    ..human jejuni, Clostridium botulinum, Escherichia coli, Listeria monocytogenes, Mycobacterium tuberculosis and Yersinia pestis. It has been shown to modulate the horizontal gene transfer and biofilm formation...
  15. Isolation of new phage enzymes to kill B. anthracis
    Vincent A Fischetti; Fiscal Year: 2013
    ..anthracis virulence, but that of other Category A biological agents with extended soil phases, like Yersinia pestis and Francisella tularensis, which also have extensive environmental phage systems...
  16. Regulation of Pore Formation by Type III Secretion System
    Gloria I Viboud; Fiscal Year: 2010
    ..well agents causing severe pneumonia, like the opportunistic bacteria Pseudomonas aeruginosa, or the deadly Yersinia pestis. Interestingly, Y...
  17. Probing localiztion, interactions, and effector properties of Shigella lpaD
    NICHOLAS EUGENE DICKENSON; Fiscal Year: 2010
    ..S. flexneri along with numerous other important pathogens such as Yersinia pestis (plague), Salmonella (gastroenteritis), and Pseudomonas aeruginosa (lung infection) utilize the type III ..
  18. Cell-mediated protection against pneumonic plague
    Jr Shiuan Lin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Yersinia pestis (Yp) - one of the world's most virulent human pathogens - is the gram-negative bacterium that causes pneumonic plague...
  19. The Electrochemistry of Diheme Cytochrome c Peroxidases
    Sean J Elliott; Fiscal Year: 2010
    ..Further, our study of triheme CCPs will elucidate the CCP machinery which is unique to pathogens such as Salmonella enterica and Yersinia pestis, providing new insights into their biochemical pathways.
  20. Alternative approaches for NALT-based immunity to respiratory pathogens
    Prosper N Boyaka; Fiscal Year: 2013
    ..derivative enhanced mucosal and systemic immunity to co-administered unrelated antigens such as recombinant Yersinia pestis F1-V antigen...
  21. Structural and functional studies of autoinducer-2 processing proteins
    Stephen T Miller; Fiscal Year: 2012
    ..the gene for LuxS, the AI-2 synthase, including pathogens such as Salmonella typhimurium, Bacillus anthracis, Yersinia pestis, and Vibrio cholerae [84]...
  22. Evaluation of Ail as a protective immunogen for plague
    Eric S Krukonis; Fiscal Year: 2012
    ..We have recently shown that Ail is important for delivery of cytotoxic Yop proteins from Yersinia pestis to phagocytic and non-phagocytic human cells...
  23. Immunotherapeutic Potential of Modified Lipooligosaccharides and Lipid A's
    Robert K Ernst; Fiscal Year: 2013
    ..by modifying the lipid A structure of the lipooligosaccharide (LOS) from an attenuated (BSL-2 approved) Yersinia pestis (Yp) strain...
  24. Multivalent Plague, Anthrax Vaccines Using Bacteriophage T4 Display
    Venigalla B Rao; Fiscal Year: 2013
    ..plague and multivalent plague-anthrax vaccines that can confer protection against Bacillus anthracis and Yersinia pestis, two Category A biodefense pathogens...
  25. Biochemical Characterization of Yersinia Effector YopJ
    Kim Orth; Fiscal Year: 2012
    ..In the case of Yersinia pestis, these virulence factors promote the pathogens proliferation at the deadly expense of the host...
  26. Role of the Plasminogen Activator Protease during Pneumonic Plague
    Wyndham W Lathem; Fiscal Year: 2013
    ..The Gram-negative bacterium Yersinia pestis causes the disease plague, which can manifest in three distinct forms: bubonic, septicemic, and pneumonic...
  27. Development of a Novel Lead Series Against Category A &B Bacterial Pathogens
    Terry L Bowlin; Fiscal Year: 2013
    ..of the growth of Gram-negative bacterial species, including a number of Category A and B agents such as Yersinia pestis, Francisella tularensis, Burkholderia mallei and pseudomallei...
  28. Immune Responses to Biodefense Vaccines Early in Life
    Marcela F Pasetti; Fiscal Year: 2010
    ..vaccines based on attenuated Salmonella as a live vector to mucosally deliver protective antigens from Yersinia pestis and Bacillus anthracis...
  29. Non-clinical Development of Bactericidal Proteins Targeting Plague
    DAVID WILLIAM MARTIN; Fiscal Year: 2010
    ..1 project we have developed R-type pyocins, targetable bactericidal proteins, that kill the plague bacterium, Yersinia pestis, in vitro and are not sensitive to the mechanisms that bacteria use to resist antibiotics...
  30. NMR studies of heterocyclization and epimerization in yersiniabactin synthesis
    DOMINIQUE PASCAL FRUEH; Fiscal Year: 2013
    ..that participates in the synthesis of yersiniabactin (Ybt), a virulence factor found in pathogens such as Yersinia pestis, the causative agent of the bubonic plague, Y. enterocolitica, a food pathogen, and uropathogenic E...
  31. Novel antiobiotic development for biodefense
    Michael E Johnson; Fiscal Year: 2010
    Bacillus anthracis, Francisella tularensis and Yersinia pestis, the causative agents for anthrax, tularemia and plague, respectively, are all classed as Category A agents due to their potential use in bioterrorism and biowarfare...
  32. Modulation of Inflammasome Activation by Yersinia
    Igor E Brodsky; Fiscal Year: 2013
    ..which expresses many of the same virulence factors as its close relative and plague pathogen Yersinia pestis, as a model to understand the host- pathogen interface and discover shared features of host innate immune ..
  33. An Animal Biosafety Level 3 Laboratory for Stony Brook University
    Samuel L Stanley; Fiscal Year: 2010
    ..for research involving laboratory animals and studies with the Select Agents Francisella tularensis and Yersinia pestis (both CDC Category A);Mycobacterium tuberculosis;pathogens of unknown in vivo virulence;arthropods infected ..
  34. NOD-Like Receptor Signaling is Critical to Secondhand Smoke-Induced Immunity and
    Sanjay Batra; Fiscal Year: 2013
    ..along with attenuated production of IL-18, IL-1[unreadable], and IFN-? after subcutaneous or intraperitoneal Yersinia pestis infection...
  35. Evaluating the Progression of Pneumonic Plague
    Roger Pechous; Fiscal Year: 2012
    Pneumonic plague results from the inhalation of the bacterium Yersinia pestis. Due to its lethality, rapid disease progression, and ability to be disseminated via aerosolization, Y. pestis is categorized by the U.S...
  36. Genetic and molecular basis of host resistance to Yersinia pestis.
    RICHARD IAN TAPPING; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Yersinia pestis is the causative agent of bubonic, septicemic and pneumonic plague and represents a serious bioterrorism threat. Most studies on Y...
  37. The role of LPS-TLR4 signaling in live vaccine-induced protective responses
    Egil Lien; Fiscal Year: 2013
    ..goal is to define mechanisms for immune protection by Gram-negative bacterial vaccine strains, using novel Yersinia pestis strains as model systems. The gram-negative bacterium Yersinia pestis is the causative agent of plague...
  38. Molecular Mechanism of Translocon Assembly into Cell Plasma Membranes
    ALEJANDRO PABLO HEUCK; Fiscal Year: 2013
    ..g., blocking phagocytosis), modulating the host response in favor of infection. Collected evidence in Yersinia pestis and Pseudomonas aeruginosa suggests that two secreted T3S proteins insert into the target cell membrane and ..
  39. ROLE OF YAPS IN Y. PESTIS PATHOGENESIS
    Virginia L Miller; Fiscal Year: 2010
    b>Yersinia pestis is a Gram-negative bacterial human pathogen that is the causative agent of plague. Historically Y. pestis has been responsible for significant human morbidity and mortality. However, Y...
  40. Small, noncoding RNAs and the evolution of Yersinia pestis virulence
    Wyndham W Lathem; Fiscal Year: 2013
    ..These alterations may result in genetically related bacteria that are phenotypically quite distinct. Yersinia pestis, responsible for the devastating disease plague, and Yersinia pseudotuberculosis, the causative agent of the ..
  41. Regulation of Innate Immunity by Pyrin Proteins
    Jonathan A Harton; Fiscal Year: 2012
    ..diseases and innate immune response towards a growing number of pathogens, including Bacillus anthracis, Yersinia pestis, and Francisella tularensis...
  42. Targeting bacterial phosphatases for novel anti-bacterial agents.
    Maurizio Pellecchia; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Yersinia pestis, Salmonella enterica, and Yersinia enterocolitica use a number of toxins to evade the immune system one of which is the protein tyrosine phosphatase YopH...
  43. Improved plague vaccine by targeting dendritic cell subsets
    Yoonkyung Do; Fiscal Year: 2010
    Plague caused by the bacterium, Yersinia pestis (Y. pestis) remains an infectious disease of concern to public health due to the absence of a vaccine for humans and the isolation of antibiotic-resistant bacteria. Y...
  44. Sodium bioenergetics in Yersinia pestis
    CLAUDIA C HASE; Fiscal Year: 2010
    ..Although little is known about the role of the sodium cycle of energy during infection by Yersinia pestis, the presence of several sodium-dependent systems in the genome of this organism strongly suggests that this ..
  45. Attenuated Live and Recombinant Yersinia pestis Vaccines
    Roy Curtiss; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Yersinia pestis, in three pandemics, resulted in some 200 million plague deaths and is still endemic throughout the world resulting in sporadic infections...
  46. Phage-mediated bioluminescent detection of Yersinia pestis
    David A Schofield; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Yersinia pestis is designated by the Centers for Disease Control (CDC) and NIAID as a Category A bacterial pathogen. Y...
  47. Developing a Novel Plague Antibiotic by Targeting Protein Secretion
    Floyd E Romesberg; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Yersinia pestis, the causative agent of plague, was the most deadly of all the bacterial pathogens in ancient and medieval times...
  48. A novel ternary virulence system in plague
    Susan C Straley; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Yersinia pestis is the causative agent of plague in humans...
  49. Bacteriolytic phage enzymes as novel antibacterials against Yersinia pestis
    Ian Molineux; Fiscal Year: 2009
    ..In particular, some isolates of Yersinia pestis, the causative agent of plague, are known to harbor multiple resistance determinants to commonly used ..
  50. Development and Formulation of Broad Spectrum Antimicrobials for Biodefense
    Richard A Slayden; Fiscal Year: 2010
    ..the diseases caused by priority pathogens such as Francisella tularensis, Burkholderia pseudomallei and Yersinia pestis. We have developed a series of high affinity inhibitors of the fatty acid biosynthesis enoyl reductase (Fabl) ..
  51. Oral Vaccine Platform for Yersinia pestis
    Lloyd F Mayer; Fiscal Year: 2012
    ..In this RO1, we propose to expand our platform technology to develop an oral vaccine against a Category A, bacterial bioterrorism agent, Y. pestis, a highly lethal agent capable of inducing mass casualties. ..
  52. Bacterial cell killing by topoisomerase I mediated DNA lesion
    Yuk Ching Tse-Dinh; Fiscal Year: 2013
    ..would be given to compounds with low toxicity that are active against gram negative Escherichia coli and Yersinia pestis in order to identify leads that can be used in development of therapeutic agents against gram negative ..
  53. Yersiniabactin and plague pathogenesis
    ROBERT DONALD PERRY; Fiscal Year: 2013
    b>Yersinia pestis causes a zoonotic disease, plague, with well established reservoirs on every inhabited continent except Australia...
  54. Regulation of Yersenia pestis virulence genes in response to host cell contact
    Deborah M Anderson; Fiscal Year: 2010
    b>Yersinia pestis translocate virulence factors from the bacterial cytoplasm into host immune cells during infections through the Type III Secretion System (TTSS)...
  55. Multiplex PCR Detection of CDC 'A' Bioterrorism Agents
    Kelly Henrickson; Fiscal Year: 2005
    ..category "A") to pose the greatest threat include Variola major (smallpox), Bacillus anthracis (anthrax), Yersinia pestis (plague), Clostridium botulinum toxin (botulism), Francisella tularensis (tularemia), and a group of RNA ..
  56. Translocation through TonB-dependent transporters
    Karen Jakes; Fiscal Year: 2013
    ..coli bacteria, as well as pathogens such as Yersinia pestis, acquire essential nutrients such as iron and vitamin B12 through a group of ligand-gated outer membrane ..
  57. Factors Affecting Dissemination Events Early in Bubonic Plague
    Virginia L Miller; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Yersinia pestis is the causative agent of disease in a variety of mammals, and humans can become infected when human and animal ecologies intersect...
  58. The Role of LPS and Toll-like Receptors in Plague
    Egil Lien; Fiscal Year: 2010
    The gram-negative bacterium Yersinia pestis is the causative agent of plague. Y...
  59. Role of Yersinia pestis Ail in Yop delivery and plague
    Eric S Krukonis; Fiscal Year: 2012
    ..We have recently determined that the Yersinia pestis adhesin Ail facilitates T3S of Yersinia outer proteins (Yops) via binding to host fibronectin...
  60. Siderophore Biosynthesis Inhibitors as New Antibiotics for Biodefense
    Derek S Tan; Fiscal Year: 2010
    ..of siderophore biosynthesis in two bacteria that are NIAID Priority Pathogens for biodefense research: Yersinia pestis, the causative agent of plague, and Yersinia enterocolitica, a gastroenteritic water- and foodborne pathogen...
  61. HTS assay and configuration for inhibitors of the UDP-Mur formation pathway
    Michael McNeil; Fiscal Year: 2009
    ..a methicillin resistant Staphylococcus aureus and bioterrorist agents including Burkholderia pseudomallei and Yersinia pestis. Here, we target the formation of the key PG biosynthetic precursor, UDP-N-acetyl muramic acid (UDP-MurNAc)...
  62. MOLECULAR MECHANISMS OF YERSINIA PESTIS PERSISTENCE IN THE FLEA VECTOR
    Viveka Vadyvaloo; Fiscal Year: 2013
    ..the risk of transmission and human disease, and an enzootic/quiescent stage in which the causative bacterium, Yersinia pestis, persists and maintains the reservoir...
  63. Development of a Drosophila model to study vector colonization by Yersinia pestis
    MELANIE MARKETON; Fiscal Year: 2013
    ..by developing a new model system in which to identify genetic factors important for the interaction of Yersinia pestis (causative agent of plague) with its flea vector...
  64. Early Events in the Pathogenesis of Pneumonic Plague
    William E Goldman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pneumonic plague is the deadliest form of disease caused by Yersinia pestis and the basis for this bacterium's classification as a Category A Select Agent...
  65. HTS assay development for bacterial transcription factors
    Richard E Wolf; Fiscal Year: 2013
    ..the efficacy of these compounds using in vitro and in vivo infection models for Salmonella Typhimurium, a bacterium responsible for millions of infections annually in the US, and Yersinia pestis (plague), a major bioterrorism threat.
  66. Development of RSK Inhibitors as Novel Therapeutics for Yersinia pestis
    Jeffrey Smith; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Yersinia pestis, the causative agent of the plague, has been weaponized as an agent of biowarfare. The deliberate release of weaponized Y...
  67. Applicability of smartDNA Rapid Detection of Priority Agents in Food
    RICHARD BLIDNER; Fiscal Year: 2009
    ..responders for the detection of multiple bio-terrorism agents (Bacillus anthracis, Francisella tularensis and Yersinia pestis)...
  68. Bacterial Pathogen Amplification & Real-Time Detection
    JACK U REN; Fiscal Year: 2003
    ..However in addition to the Category A agents like anthrax, Yersinia pestis and smallpox, which are difficult to safely grow and disseminate, exist the Category B agents that could be ..
  69. Molecular mechanism of immune evasion by Yersinia pestis
    Tomas Mustelin; Fiscal Year: 2003
    ..Due to its very rapid replication and effective immune evading capacity, Yersinia pestis has recently been recognized as a potential tool for bioterrorism...
  70. BACTERIAL PATHOGEN GENOME INITIATIVE
    Frederick Blattner; Fiscal Year: 1999
    ..In addition to these E. coli genomes we will determine the genomic sequence of Yersinia pestis KIM, causative agent of plague, Shigella flexneri 2 a, the principle agent of dysentary, and Salmonella typhi ..
  71. Choosing Drug Doses for Biodefense Pathogens
    George Drusano; Fiscal Year: 2009
    ..doses and schedules of drugs to treat patients infected with the Bioterror pathogens Bacillus anthracis, Yersinia pestis and the Pox viruses Vaccinia Virus and Cowpox Virus...
  72. Structure of the multidrug efflux protein AcrA
    Partho Ghosh; Fiscal Year: 2006
    ..RND efflux systems are also encoded by Escherichia coli O157:H7, Salmonella enterica, Shigella flexneri, and Yersinia pestis. The most thoroughly characterized RND system is the E...
  73. Phage-mediated bioluminescent detection of Yersinia pestis.
    David Schofield; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Yersinia pestis is designated by the Centers for Disease Control (CDC) and NIAID as a Category A priority bacterial pathogen. Y...
  74. Mechanism of anti-phagocytosis by Yersinia pestis
    Kristiina Vuori; Fiscal Year: 2005
    b>Yersinia pestis, the causative agent of plague, is one of the most pathogenic bacteria known to mankind. Due to its high pathogenicity, Yersinia has been recognized as a potential weapon for bioterrorism...
  75. A Novel Treatment in a Bioterrorism Model of Pneumonic Plague Targets A1 ARs
    CONSTANCE WILSON; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Yersinia pestis (Y...
  76. RovA regulon of Yersinia pestis
    VIRGINIA MILLER; Fiscal Year: 2003
    b>Yersinia pestis is a Gram-negative bacterial human pathogen that is the causative agent of plague. Historically Y. pestis has been responsible for significant human morbidity and mortality...
  77. Development, Production and Evaluation of a Multivalent Adenoviral Plague Vaccine
    CHRIS LENTZ; Fiscal Year: 2009
    ..construct and test a multivalent adenoviral vaccine candidate that elicits a potent immune response against Yersinia pestis, the causative agent of plague...
  78. SYSTEMIC LYMPH NODE SPECIFIC AGENTS
    MIKHAIL PAPISOV; Fiscal Year: 2003
    ..and treatment of diseases caused by Category A pathogens, in particular Bacillus anthracis (anthrax), Yersinia pestis (plague), and Francisella tularensis (tularemia)...