yersinia enterocolitica

Summary

Summary: A species of the genus YERSINIA, isolated from both man and animal. It is a frequent cause of bacterial gastroenteritis in children.

Top Publications

  1. ncbi Molecular epidemiology of Yersinia enterocolitica infections
    Maria Fredriksson-Ahomaa
    Institute of Hygiene and Technology of Food of Animal Origin, Ludwig Maximilian University, Munich, Germany
    FEMS Immunol Med Microbiol 47:315-29. 2006
  2. pmc Role of lipid A acylation in Yersinia enterocolitica virulence
    Camino Pérez-Gutiérrez
    Fundación Caubet CIMERA Illes Balears, 07110 Bunyola, Spain
    Infect Immun 78:2768-81. 2010
  3. pmc Pathogenic strains of Yersinia enterocolitica isolated from domestic dogs (Canis familiaris) belonging to farmers are of the same subtype as pathogenic Y. enterocolitica strains isolated from humans and may be a source of human infection in Jiangsu Provin
    Xin Wang
    National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, P O Box 5, Changping 102206, Beijing, People s Republic of China
    J Clin Microbiol 48:1604-10. 2010
  4. pmc Low occurrence of pathogenic Yersinia enterocolitica in clinical, food, and environmental samples: a methodological problem
    Maria Fredriksson-Ahomaa
    Department of Food and Environmental Hygiene, University of Helsinki, Helsinki, Finland
    Clin Microbiol Rev 16:220-9. 2003
  5. ncbi Epidemiological data on pathogenic Yersinia enterocolitica in Southern Germany during 2000-2006
    Michael Bucher
    Bayerisches Landesamt fuer Gesundheit und Lebensmittelsicherheit, Oberschleissheim, Germany
    Foodborne Pathog Dis 5:273-80. 2008
  6. pmc Deciphering the assembly of the Yersinia type III secretion injectisome
    Andreas Diepold
    Infection Biology, Biozentrum der Universitat Basel, Basel, Switzerland
    EMBO J 29:1928-40. 2010
  7. pmc Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica
    Deyan Luo
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 187:1866-76. 2011
  8. pmc Polymerization of a single protein of the pathogen Yersinia enterocolitica into needles punctures eukaryotic cells
    E Hoiczyk
    Laboratory of Cell Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 98:4669-74. 2001
  9. pmc Characterization of a large chromosomal "high-pathogenicity island" in biotype 1B Yersinia enterocolitica
    E Carniel
    Unité de bactériologie moléculaire et médicale, Laboratoire des Yersinia, Institut Pasteur, Paris, France
    J Bacteriol 178:6743-51. 1996
  10. pmc Genomic characterization of the Yersinia genus
    Peter E Chen
    Biological Defense Research Directorate, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, USA
    Genome Biol 11:R1. 2010

Detail Information

Publications311 found, 100 shown here

  1. ncbi Molecular epidemiology of Yersinia enterocolitica infections
    Maria Fredriksson-Ahomaa
    Institute of Hygiene and Technology of Food of Animal Origin, Ludwig Maximilian University, Munich, Germany
    FEMS Immunol Med Microbiol 47:315-29. 2006
    b>Yersinia enterocolitica is an important food-borne pathogen that can cause yersiniosis in humans and animals. The epidemiology of Y. enterocolitica infections is complex and remains poorly understood...
  2. pmc Role of lipid A acylation in Yersinia enterocolitica virulence
    Camino Pérez-Gutiérrez
    Fundación Caubet CIMERA Illes Balears, 07110 Bunyola, Spain
    Infect Immun 78:2768-81. 2010
    b>Yersinia enterocolitica is an important human pathogen. Y. enterocolitica must adapt to the host environment, and temperature is an important cue regulating the expression of most Yersinia virulence factors. Here, we report that Y...
  3. pmc Pathogenic strains of Yersinia enterocolitica isolated from domestic dogs (Canis familiaris) belonging to farmers are of the same subtype as pathogenic Y. enterocolitica strains isolated from humans and may be a source of human infection in Jiangsu Provin
    Xin Wang
    National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, P O Box 5, Changping 102206, Beijing, People s Republic of China
    J Clin Microbiol 48:1604-10. 2010
    We isolated 326 Yersinia enterocolitica strains from 5,919 specimens from patients with diarrhea at outpatient clinics, livestock, poultry, wild animals, insect vectors, food, and the environment in the cities of Nantong and Xuzhou in ..
  4. pmc Low occurrence of pathogenic Yersinia enterocolitica in clinical, food, and environmental samples: a methodological problem
    Maria Fredriksson-Ahomaa
    Department of Food and Environmental Hygiene, University of Helsinki, Helsinki, Finland
    Clin Microbiol Rev 16:220-9. 2003
    While Yersinia enterocolitica is an important pathogen, which can cause yersiniosis in humans and animals, its epidemiology remains obscure. The pig is the major reservoir of pathogenic Y...
  5. ncbi Epidemiological data on pathogenic Yersinia enterocolitica in Southern Germany during 2000-2006
    Michael Bucher
    Bayerisches Landesamt fuer Gesundheit und Lebensmittelsicherheit, Oberschleissheim, Germany
    Foodborne Pathog Dis 5:273-80. 2008
    b>Yersinia enterocolitica is the most common species causing enteric yersiniosis, which is still the third most frequently reported foodborne gastroenteritis in Europe. Y...
  6. pmc Deciphering the assembly of the Yersinia type III secretion injectisome
    Andreas Diepold
    Infection Biology, Biozentrum der Universitat Basel, Basel, Switzerland
    EMBO J 29:1928-40. 2010
    The assembly of the Yersinia enterocolitica type III secretion injectisome was investigated by grafting fluorescent proteins onto several components, YscC (outer-membrane (OM) ring), YscD (forms the inner-membrane (IM) ring together with ..
  7. pmc Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica
    Deyan Luo
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 187:1866-76. 2011
    ..for coagulation leading to fibrin deposition during host defense against the Gram-negative bacterium Yersinia enterocolitica. After i.p. inoculation with Y...
  8. pmc Polymerization of a single protein of the pathogen Yersinia enterocolitica into needles punctures eukaryotic cells
    E Hoiczyk
    Laboratory of Cell Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 98:4669-74. 2001
    ..In the pathogen Yersinia enterocolitica, the primary structure of the secreted proteins as well as of the components of the secretion machinery, ..
  9. pmc Characterization of a large chromosomal "high-pathogenicity island" in biotype 1B Yersinia enterocolitica
    E Carniel
    Unité de bactériologie moléculaire et médicale, Laboratoire des Yersinia, Institut Pasteur, Paris, France
    J Bacteriol 178:6743-51. 1996
    ..enterocolitica strains of biotype 1B indicates that most of the island is conserved, apart from 15 kb at the left-hand end which is variable, especially in the region where three repeated sequences are clustered...
  10. pmc Genomic characterization of the Yersinia genus
    Peter E Chen
    Biological Defense Research Directorate, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, USA
    Genome Biol 11:R1. 2010
    ..genus Yersinia that cause invasive human diseases (Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica) had been sequenced...
  11. ncbi Construction and characterisation of a Yersinia enterocolitica O:8 ompR mutant
    N Dorrell
    Department of Medical Microbiology, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
    FEMS Microbiol Lett 165:145-51. 1998
    ..A Yersinia enterocolitica O:8 ompR homologue was amplified, cloned and sequenced, showing 99...
  12. ncbi The osmotic regulator OmpR is involved in the response of Yersinia enterocolitica O:9 to environmental stresses and survival within macrophages
    Katarzyna Brzostek
    Institute of Microbiology, Warsaw University, 02 096 Warsaw Miecznikowa 1, Poland
    FEMS Microbiol Lett 228:265-71. 2003
    Various environmental signals control the expression of the virulence factors in pathogenic Yersinia enterocolitica strains...
  13. pmc Yersinia enterocolitica serum resistance proteins YadA and ail bind the complement regulator C4b-binding protein
    Vesa Kirjavainen
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland
    PLoS Pathog 4:e1000140. 2008
    ..b>Yersinia enterocolitica, a Gram-negative enteric pathogen with invasive properties, efficiently resists the deleterious action of ..
  14. ncbi Type III secretion translocation pores of Yersinia enterocolitica trigger maturation and release of pro-inflammatory IL-1beta
    Hwain Shin
    Biozentrum, University of Basel, Basel, Switzerland
    Cell Microbiol 9:2893-902. 2007
    ..While macrophages infected by wild-type Yersinia enterocolitica did not release mature IL-1beta, macrophages infected by Y...
  15. ncbi The RovA regulons of Yersinia enterocolitica and Yersinia pestis are distinct: evidence that many RovA-regulated genes were acquired more recently than the core genome
    Jason S Cathelyn
    Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Ave, Saint Louis, MO 63110, USA
    Mol Microbiol 66:189-205. 2007
    ..This repression can be selectively relieved by regulators such as RovA, and the observation that nearly all RovA-activated genes are repressed by H-NS is consistent with this model...
  16. ncbi C-terminal amino acid residues of the trimeric autotransporter adhesin YadA of Yersinia enterocolitica are decisive for its recognition and assembly by BamA
    U Lehr
    Institute for Medical Microbiology und Hygiene, University Hospital Tubingen, Elfriede Aulhornstr 6, Tubingen D 72076, Germany
    Mol Microbiol 78:932-46. 2010
    ..The Yersinia enterocolitica Adhesin A (YadA) is the prototype of trimeric auotransporter adhesins (TAAs), consisting of a head, stalk ..
  17. pmc Functional mapping of YadA- and Ail-mediated binding of human factor H to Yersinia enterocolitica serotype O:3
    Marta Biedzka-Sarek
    Department of Bacteriology and Immunology, Haartman Institute, P O Box 21, 00014 University of Helsinki, Helsinki, Finland
    Infect Immun 76:5016-27. 2008
    b>Yersinia enterocolitica is an enteric pathogen that exploits diverse means to survive in the human host. Upon Y. enterocolitica entry into the human host, bacteria sense and respond to variety of signals, one of which is the temperature...
  18. pmc Outbreak of Yersinia enterocolitica serogroup O:9 infection and processed pork, Norway
    Danica Grahek-Ogden
    Norwegian Institute of Public Health, Oslo, Norway
    Emerg Infect Dis 13:754-6. 2007
    An outbreak involving 11 persons infected with Yersinia enterocolitica O:9 was investigated in Norway in February 2006. A case-control study and microbiologic investigation indicated a ready-to-eat pork product as the probable source...
  19. pmc VirG, a Yersinia enterocolitica lipoprotein involved in Ca2+ dependency, is related to exsB of Pseudomonas aeruginosa
    A Allaoui
    Microbial Pathogenesis Unit, Universite Catholique de Louvain, Brussels, Belgium
    J Bacteriol 177:4230-7. 1995
    ..Here we describe the virG gene of Yersinia enterocolitica; virG is located just upstream of the virF gene, which encodes the transcriptional activator of some ..
  20. ncbi Characterization of the ysa pathogenicity locus in the chromosome of Yersinia enterocolitica and phylogeny analysis of type III secretion systems
    Boris Foultier
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Faculté de Médecine, Universite Catholique de Louvain, Belgium
    J Mol Evol 55:37-51. 2002
    ..All the TTSSs fall into five different clusters. The phylogenetic tree of these TTSSs is completely different from the evolutionary tree based on 16S RNA, indicating that TTSSs have been distributed by horizontal transfer...
  21. ncbi Common antigenicity between Yersinia enterocolitica-derived heat-shock protein and the retina, and its role in uveitis
    T Tanaka
    Department of Ophthalmology, Tokyo Medical College Hospital, Japan
    Ophthalmic Res 28:284-8. 1996
    b>Yersinia enterocolitica-derived heat-shock protein (HSP60) was recently demonstrated to be associated with certain systemic autoimmune diseases...
  22. ncbi Activation of NF-kappaB and IL-8 by Yersinia enterocolitica invasin protein is conferred by engagement of Rac1 and MAP kinase cascades
    Guntram A Grassl
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Universitatsklinikum Tubingen, D 72076 Tubingen, Germany
    Cell Microbiol 5:957-71. 2003
    b>Yersinia enterocolitica triggers activation of the nuclear factor (NF)-kappaB and production of the proinflammatory chemokine interleukin (IL)-8 in intestinal epithelial cells...
  23. pmc Passive immunity to infection with Yersinia spp. mediated by anti-recombinant V antigen is dependent on polymorphism of V antigen
    A Roggenkamp
    Max von Pettenkofer Institute for Hygiene and Microbiology, Ludwig Maximilian University of Munich, Germany
    Infect Immun 65:446-51. 1997
    ..DNA sequencing of the most common serotypes of human pathogenic Yersinia enterocolitica and Y...
  24. pmc Genotyping of human and porcine Yersinia enterocolitica, Yersinia intermedia, and Yersinia bercovieri strains from Switzerland by amplified fragment length polymorphism analysis
    Kathrin Kuehni Boghenbor
    Institute of Veterinary Bacteriology, Postfach, CH 3001 Bern, Switzerland
    Appl Environ Microbiol 72:4061-6. 2006
    In this study, 231 strains of Yersinia enterocolitica, 25 strains of Y. intermedia, and 10 strains of Y...
  25. pmc A program of Yersinia enterocolitica type III secretion reactions is activated by specific signals
    V T Lee
    Department of Microbiology and Immunology, University of California Los Angeles School of Medicine, Los Angeles, California 90095, USA
    J Bacteriol 183:4970-8. 2001
    ..b>Yersinia enterocolitica cells sense an increase in extracellular amino acids (glutamate, glutamine, aspartate, and asparagine) ..
  26. pmc Unique cell adhesion and invasion properties of Yersinia enterocolitica O:3, the most frequent cause of human Yersiniosis
    Frank Uliczka
    Department of Molecular Infection Biology, Helmholtz Zentrum für Infektionsforschung, Braunschweig, Germany
    PLoS Pathog 7:e1002117. 2011
    ....
  27. pmc YmoA negatively regulates expression of invasin from Yersinia enterocolitica
    Damon W Ellison
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Bacteriol 185:7153-9. 2003
    inv encodes invasin, which is the primary invasion factor of Yersinia enterocolitica. inv expression in vitro is regulated in response to temperature, pH, and growth phase...
  28. pmc From pig to pacifier: chitterling-associated yersiniosis outbreak among black infants
    Timothy F Jones
    Tennessee Department of Health, Nashville, Tennessee 37247, USA
    Emerg Infect Dis 9:1007-9. 2003
    In this case-control study of Yersinia enterocolitica infections among black infants, chitterling preparation was significantly associated with illness (p<0.001)...
  29. ncbi Contamination of carcasses with human pathogenic Yersinia enterocolitica 4/O:3 originates from pigs infected on farms
    Riikka Laukkanen
    Department of Food and Environmental Hygiene, Helsinki University, Finland
    Foodborne Pathog Dis 6:681-8. 2009
    Pigs are considered as a major reservoir of human pathogenic Yersinia enterocolitica and a source of human yersiniosis. However, the transmission route of Y. enterocolitica from farm to pork is still unclear...
  30. ncbi Molecular epidemiology of Yersinia enterocolitica 4/O:3
    Maria Fredriksson-Ahomaa
    Institute of Hygiene and Technology of Food of Animal Origin, Ludwig Maximilians University, Munich, Germany
    Adv Exp Med Biol 529:295-302. 2003
  31. pmc Development of multiple-locus variable-number tandem-repeat analysis for Yersinia enterocolitica subsp. palearctica and its application to bioserogroup 4/O3 subtyping
    Rafał Gierczyński
    Department of Bacteriology, National Institute of Hygiene, Chocimska 24, 00 791 Warsaw, Poland
    J Clin Microbiol 45:2508-15. 2007
    b>Yersinia enterocolitica bioserogroup 4/O3 is the predominant causative agent of yersiniosis in Europe and North America...
  32. ncbi Detection of Salmonella spp., Yersinia enterocolitica and verocytotoxin-producing Escherichia coli O157 in pigs at slaughter in Italy
    S Bonardi
    Dipartimento di Salute Animale, Sezione di Ispezione degli Alimenti di Origine Animale, Facolta di Medicina Veterinaria, Universita di Parma, Via del Taglio 8, 43100, Parma, Italy
    Int J Food Microbiol 85:101-10. 2003
    ..Caecal material and carcass swabs were collected and examined for Salmonella, Yersinia enterocolitica, and Escherichia coli O157. Tonsils were examined for Salmonella and Y. enterocolitica...
  33. ncbi Outbreak of food poisoning by Yersinia enterocolitica serotype O8 in Nara prefecture: the first case report in Japan
    Takeshi Sakai
    Division of Bacteriology, Nara Prefectural Institute of Hygiene and Environment, Nara 630 8131, Japan
    Jpn J Infect Dis 58:257-8. 2005
  34. pmc Role of the pilot protein YscW in the biogenesis of the YscC secretin in Yersinia enterocolitica
    Peter Burghout
    Department of Molecular Microbiology and Institute of Biomembranes, Utrecht University, 3584 CH Utrecht, The Netherlands
    J Bacteriol 186:5366-75. 2004
    The YscC secretin is a major component of the type III protein secretion system of Yersinia enterocolitica and forms an oligomeric structure in the outer membrane...
  35. ncbi YopT, a new Yersinia Yop effector protein, affects the cytoskeleton of host cells
    M Iriarte
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology, and Faculté de Médecine, Universite Catholique de Louvain, Brussels, Belgium
    Mol Microbiol 29:915-29. 1998
    ..This cytotoxic effect was caused by YopT and dependent on YopB. YopT is thus a new effector Yop and a new bacterial toxin affecting the cytoskeleton of eukaryotic cells...
  36. pmc Complete genome sequence of a Yersinia enterocolitica "Old World" (3/O:9) strain and comparison with the "New World" (1B/O:8) strain
    Xin Wang
    National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, 102206 Beijing, China
    J Clin Microbiol 49:1251-9. 2011
    b>Yersinia enterocolitica is a heterogeneous bacterial species with a wide range of animal reservoirs through which human intestinal illness can be facilitated...
  37. ncbi Catalytically active Yersinia outer protein P induces cleavage of RIP and caspase-8 at the level of the DISC independently of death receptors in dendritic cells
    Sabine Gröbner
    Institute of Medical Microbiology and Hygiene, University of Tubingen, Elfriede Aulhorn Str, 6, 72076, Tuebingen, Germany
    Apoptosis 12:1813-25. 2007
    ..Here we show the pathways involved in DC death caused by the catalytic activity of YopP. Infection with Yersinia enterocolitica, translocating catalytically active YopP into DC, triggered procaspase-8 cleavage and c-FLIPL degradation...
  38. pmc Yersinia pestis endowed with increased cytotoxicity is avirulent in a bubonic plague model and induces rapid protection against pneumonic plague
    Ayelet Zauberman
    Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona, Israel
    PLoS ONE 4:e5938. 2009
    ..effector YopJ, as opposed to the readily translocated YopP, the YopJ homologue of the enteropathogen Yersinia enterocolitica Oratio8...
  39. ncbi Function and molecular architecture of the Yersinia injectisome tip complex
    Petr Broz
    Biozentrum der Universitat Basel, Basel, Switzerland
    Mol Microbiol 65:1311-20. 2007
    ..analyses and scanning transmission electron microscopy (STEM), we determined that the needle of the Yersinia enterocolitica E40 injectisome consists of 139 +/- 19 YscF subunits and that the tip complex is formed by three to five ..
  40. ncbi Sporadic human Yersinia enterocolitica infections caused by bioserotype 4/O : 3 originate mainly from pigs
    Maria Fredriksson-Ahomaa
    Institute of Hygiene and Technology of Food of Animal Origin, Ludwig Maximilian University, Munich, Germany
    J Med Microbiol 55:747-9. 2006
    b>Yersinia enterocolitica 4/O : 3 is the most frequent cause of sporadic human yersiniosis in Finland and Germany...
  41. ncbi Presence of a functional flagellar cluster Flag-2 and low-temperature expression of flagellar genes in Yersinia enterocolitica W22703
    Geraldine Bresolin
    Zentralinstitut für Ernährungs und Lebensmittelforschung ZIEL, Abteilung Mikrobiologie, Technische Universitat Munchen, Weihenstephaner Berg 3, 85354 Freising, Germany
    Microbiology 154:196-206. 2008
    Twelve Yersinia enterocolitica mutants carrying luxCDABE-transposon insertions in motility and chemotaxis genes were isolated on the basis of strong low-temperature induction. Two transposons were located within an 11...
  42. ncbi Transport of haemin across the cytoplasmic membrane through a haemin-specific periplasmic binding-protein-dependent transport system in Yersinia enterocolitica
    I Stojiljkovic
    Lehrstuhl für Mikrobiologie II, Tubingen, Germany
    Mol Microbiol 13:719-32. 1994
    The Yersinia enterocolitica O:8 periplasmic binding-protein-dependent transport (PBT) system for haemin was cloned and characterized...
  43. pmc YopB and YopD constitute a novel class of Yersinia Yop proteins
    S Hakansson
    Department of Cell and Molecular Biology, University of Umea, Sweden
    Infect Immun 61:71-80. 1993
    ..present here the sequence of the distal part of the V-antigen operons of Yersinia pseudotuberculosis and Yersinia enterocolitica. The sequence information encompasses the yopB and yopD genes and a downstream region in both species...
  44. ncbi A chromosomally encoded regulator is required for expression of the Yersinia enterocolitica inv gene and for virulence
    P A Revell
    Department of Molecular Microbiology and Pediatrics, Campus Box 8230, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Microbiol 35:677-85. 2000
    The primary invasion factor of Yersinia enterocolitica, invasin, is encoded by inv. inv expression is regulated in response to pH, growth phase and temperature. In vitro, inv is maximally expressed at 26 degrees C, pH 8...
  45. pmc LcrF is the temperature-regulated activator of the yadA gene of Yersinia enterocolitica and Yersinia pseudotuberculosis
    M Skurnik
    Department of Medical Microbiology, Turku University, Finland
    J Bacteriol 174:2047-51. 1992
    ..Unlike the yop regulon, the yadA gene is not under Ca2+ regulation. Here, we show that LcrF (VirF), the temperature-regulated activator of the yop regulon, also acts as an activator for yadA...
  46. ncbi Characterization of a Type III secretion substrate specificity switch (T3S4) domain in YscP from Yersinia enterocolitica
    Céline Agrain
    Biozentrum der Universitat Basel, Basel, Switzerland
    Mol Microbiol 56:54-67. 2005
    ....
  47. ncbi OmpR negatively regulates expression of invasin in Yersinia enterocolitica
    Katarzyna Brzostek
    Department of Applied Microbiology, Institute of Microbiology, Warsaw University, Miecznikowa 1, 02 096 Warsaw, Poland
    Microbiology 153:2416-25. 2007
    Invasin, the major adhesion and invasion factor of Yersinia enterocolitica, is encoded by the inv gene, which is regulated by growth phase and in response to a variety of environmental conditions such as temperature, pH and osmolarity...
  48. pmc A specific role for TLR1 in protective T(H)17 immunity during mucosal infection
    R William DePaolo
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Exp Med 209:1437-44. 2012
    ..Using Yersinia enterocolitica, we show that oral infection promotes T(H)17 immunity, whereas systemic infection promotes T(H)1 immunity...
  49. ncbi Lipopolysaccharide O antigen status of Yersinia enterocolitica O:8 is essential for virulence and absence of O antigen affects the expression of other Yersinia virulence factors
    José Antonio Bengoechea
    Unidad de Investigación and Institut Universitari d Investigacions en Ciències de la Salut, Hospital Son Dureta, Palma de Mallorca, Spain
    Mol Microbiol 52:451-69. 2004
    ..In this work we have studied in-depth the role of the O antigen in Yersinia enterocolitica serotype O:8 pathogenesis...
  50. ncbi The pathogenic potential of Yersinia enterocolitica 1A
    Julia Batzilla
    Max von Pettenkofer Institute, LMU, Munich, Germany
    Int J Med Microbiol 301:556-61. 2011
    b>Yersinia enterocolitica 1A strains are generally considered apathogenic...
  51. pmc Molecular basis of Yersinia enterocolitica temperature-dependent resistance to antimicrobial peptides
    Mar Reinés
    Laboratory Microbial Pathogenesis, Fundació d Investigació Sanitària de les Illes Balears FISIB, Recinto Hospital Joan March, Bunyola, Spain
    J Bacteriol 194:3173-88. 2012
    ..Studies from our laboratory demonstrated that Yersinia enterocolitica is more susceptible to polymyxin B, a model AP, when grown at 37°C than at 22°C (J. A. Bengoechea, R...
  52. pmc Characterization of complement factor H binding to Yersinia enterocolitica serotype O:3
    Marta Biedzka-Sarek
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, 00014 Helsinki, Finland
    Infect Immun 76:4100-9. 2008
    ..Here we show that a gram-negative enteric pathogen, Yersinia enterocolitica serotype O:3, uses two virulence-related outer membrane (OM) proteins to bind FH. With Y...
  53. ncbi Investigation of virulence genes in clinical isolates of Yersinia enterocolitica
    Haoxuan Zheng
    Institute of Digestive Disease, Nanfang Hospital, Southern Medical University, Guangzhou, China
    FEMS Immunol Med Microbiol 53:368-74. 2008
    ..study, we aimed to investigate the distribution of virulence genes in clinical isolates of pathogenic Yersinia enterocolitica. Two thousand six hundred stool samples were collected from 2600 patients with diarrhea, and were tested ..
  54. pmc Blockade of catecholamine-induced growth by adrenergic and dopaminergic receptor antagonists in Escherichia coli O157:H7, Salmonella enterica and Yersinia enterocolitica
    Primrose P E Freestone
    Department of Infection, Immunity and Inflammation, University of Leicester School of Medicine, Leicester, UK
    BMC Microbiol 7:8. 2007
    ....
  55. pmc Roles of LcrG and LcrV during type III targeting of effector Yops by Yersinia enterocolitica
    K L DeBord
    Department of Microbiology and Immunology, University of California-Los Angeles School of Medicine, Los Angeles, CA 90095, USA
    J Bacteriol 183:4588-98. 2001
    b>Yersinia enterocolitica target effector Yop proteins into the cytosol of eukaryotic cells by a mechanism requiring the type III machinery...
  56. pmc Translocators YopB and YopD from Yersinia enterocolitica form a multimeric integral membrane complex in eukaryotic cell membranes
    Caroline Montagner
    Biozentrum der Universitat Basel, Basel, Switzerland
    J Bacteriol 193:6923-8. 2011
    ..Upon contact, it exports two hydrophobic proteins called translocators (YopB and YopD in Yersinia enterocolitica) and the effectors...
  57. ncbi Characterization of a Yersinia enterocolitica biotype 1A strain harbouring an ail gene
    B Kraushaar
    Department of Biological Safety, Federal Institute for Risk Assessment, Berlin, Germany
    J Appl Microbiol 111:997-1005. 2011
    ..We isolated an ail-positive strain and characterized this strain with phenotypic and genotypic methods to study its possible relation to pathogenic Y. enterocolitica strains...
  58. pmc Membrane association of PspA depends on activation of the phage-shock-protein response in Yersinia enterocolitica
    Saori Yamaguchi
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Mol Microbiol 78:429-43. 2010
    ..studies were used to distinguish between spatial models for this putative signal transduction pathway in Yersinia enterocolitica. In non-inducing conditions PspA and PspF were almost exclusively in the soluble fraction, consistent ..
  59. ncbi The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study
    L W Lamps
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Am J Surg Pathol 25:508-15. 2001
    ..b>Yersinia enterocolitica (YE) and Y...
  60. ncbi Inhibition of quorum sensing (QS) in Yersinia enterocolitica by an orange extract rich in glycosylated flavanones
    Pilar Truchado
    Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS CSIC, P O Box 164, 30100 Campus de Espinardo, Murcia, Spain
    J Agric Food Chem 60:8885-94. 2012
    ....
  61. pmc Broad-host-range Yersinia phage PY100: genome sequence, proteome analysis of virions, and DNA packaging strategy
    Dominik Schwudke
    Bundesinstitut für Risikobewertung, Federal Institute for Risk Assessment, Diedersdorfer Weg 1, 12277 Berlin, Germany
    J Bacteriol 190:332-42. 2008
    ..The phage forms plaques on strains of the three human pathogenic species Yersinia enterocolitica, Y. pseudotuberculosis, and Y. pestis at 37 degrees C...
  62. ncbi Modulation of inv gene expression by the OmpR two-component response regulator protein of Yersinia enterocolitica
    A Raczkowska
    Department of Applied Microbiology, University of Warsaw, Faculty of Biology, Institute of Microbiology, Miecznikowa 1, Warsaw, Poland
    Folia Microbiol (Praha) 56:313-9. 2011
    To elucidate the physiological meaning of OmpR-dependent expression of invasin gene (inv) inhibition in Yersinia enterocolitica, the function of the EnvZ/OmpR regulatory pathway in osmoregulation of inv expression was analyzed in detail...
  63. ncbi A dominant role of Toll-like receptor 4 in the signaling of apoptosis in bacteria-faced macrophages
    Rudolf Haase
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Munich, Germany
    J Immunol 171:4294-303. 2003
    ..In this study, we investigated the roles of TLR2 and TLR4 as inducers of apoptosis in Yersinia enterocolitica-infected macrophages...
  64. ncbi The quorum-hindered transcription factor YenR of Yersinia enterocolitica inhibits pheromone production and promotes motility via a small non-coding RNA
    Ching Sung Tsai
    Department of Microbiology, Cornell University, Ithaca, NY 14853, USA
    Mol Microbiol 80:556-71. 2011
    The YenR and YenI proteins of Yersinia enterocolitica resemble the quorum sensing proteins LuxR and LuxI of Vibrio fischeri. Apo-YenR activated a gene, designated yenS, that lies adjacent to and divergent from yenR...
  65. ncbi In vivo analysis of Yersinia enterocolitica infection using luxCDABE
    Janja Trcek
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilans Universität, Munich, Germany
    FEMS Microbiol Lett 307:201-6. 2010
    ..Experiments with an invasin mutant expressing luxCDABE revealed a significantly reduced number of abscessed PPs, cecal lymph follicles, and lymph nodes in yersiniae lacking invasin...
  66. ncbi Different Yersinia enterocolitica 4:O3 genotypes found in pig tonsils in Southern Germany and Finland
    M Fredriksson-Ahomaa
    Institute of Hygiene and Technology of Food of Animal Origin, University of Munich, Germany
    Syst Appl Microbiol 26:132-7. 2003
    ..These results indicate that Y. enterocolitica 4:O3 genotypes have a differential geographical distribution and thus can be used in epidemiological studies...
  67. ncbi Prevalence, antibiotic susceptibility, and virulence factors of Yersinia enterocolitica and related species from ready-to-eat vegetables available in Korea
    Tex Soo Lee
    Institute of Health and Environment of Kangwondo, Chunchon 200 702, Korea
    J Food Prot 67:1123-7. 2004
    ..biotypes, serotypes, and susceptibility to 12 antibiotics and tested for virulence genes of pathogenic Yersinia enterocolitica isolates by PCR assay. Among the samples, 27 (4.0%) were found to be contaminated with Yersinia spp...
  68. ncbi Yersinia enterocolitica serovar O:8 infection in breeding monkeys in Japan
    Taketoshi Iwata
    Division of Animal Life Science, Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan
    Microbiol Immunol 49:1-7. 2005
    ..We examined the organs of 3 of the dead squirrel monkeys and of the dark-handed gibbon, and Yersinia enterocolitica serovar O:8, which is the most pathogenic serovar of Y. enterocolitica, was isolated...
  69. ncbi Genotypic and phenotypic characteristics of Yersinia enterocolitica isolated from the surface of chicken eggshells obtained in Argentina
    Gabriela I Favier
    Microbiología General, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, 5700 San Luis, Argentina
    J Food Prot 68:1812-5. 2005
    The prevalence of Yersinia enterocolitica on chicken eggshell surfaces in San Luis, Argentina, was investigated...
  70. ncbi Invasion and dissemination of Yersinia enterocolitica in the mouse infection model
    Konrad Trulzsch
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximillians University, Munich, Germany
    Adv Exp Med Biol 603:279-85. 2007
    b>Yersinia enterocolitica is one of the most common causes of food borne gastrointestinal disease. After oral uptake yersiniae replicate in the small intestine, invade Peyer's patches of the distal ileum and disseminate to spleen and liver...
  71. ncbi Molecular genetic typing of Yersinia enterocolitica serovar O:8 isolated in Japan
    Hideki Hayashidani
    Tokyo University of Agriculture and Technology, 3 5 8 Saiwai cho, Fuchu, Tokyo 183 8509, Japan
    Adv Exp Med Biol 529:363-5. 2003
  72. pmc Identification and characterization of pathogenic Yersinia enterocolitica isolates by PCR and pulsed-field gel electrophoresis
    S Thisted Lambertz
    National Food Administration, Research and Development Department, PO Box 622, SE 751 26 Uppsala, Sweden
    Appl Environ Microbiol 71:3674-81. 2005
    ..Although pigs are thought to be the main reservoir of food-borne pathogenic Yersinia enterocolitica, the role of pork meat as a vehicle for transmission to humans is still unclear...
  73. ncbi Detection of chromosomal and plasmid--encoded virulence determinants in Yersinia enterocolitica and other Yersinia spp. isolated from food animals in Greece
    Nektaria Kechagia
    Athens Medical School, Aeginition Hospital, Department of Biopathology and Clinical Microbiology, Vass Sophias av 72 74, 115 28, Athens, Greece
    Int J Food Microbiol 118:326-31. 2007
    ..Remarkable was the association between the presence of each virulence gene separately and resistance to some antimicrobials, a matter of further investigation...
  74. ncbi O:8 serotype Yersinia enterocolitica strains in China
    Xin Wang
    National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 102206, Beijing, China
    Int J Food Microbiol 125:259-66. 2008
    Serotypes O:3, O:8 and O:9 Yersinia enterocolitica strains carrying virulence determinants are common pathogens causing human infections. In many years of surveillance in China for Y...
  75. ncbi Prevalence of pathogenic Yersinia enterocolitica in pigs slaughtered at a Swiss abattoir
    Maria Fredriksson-Ahomaa
    Institute of Hygiene and Technology of Food of Animal Origin, Faculty of Veterinary Medicine, Ludwig Maximilian University, Munich, Germany
    Int J Food Microbiol 119:207-12. 2007
    ..However, epidemiological data on the prevalence of pathogenic Yersinia enterocolitica in animals and humans is insufficient. Pigs are assumed to be the main reservoir of pathogenic Y...
  76. pmc Axillary abscess due to Yersinia enterocolitica
    Barbara E Menzies
    Infectious Disease Section, S 111 ID, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    J Clin Microbiol 48:3438-9. 2010
    b>Yersinia enterocolitica rarely causes extraintestinal disease. A 54-year-old construction worker with chronic hepatitis C developed an axillary abscess following an injury to his finger. An aspirate from the axillary mass grew Y...
  77. ncbi Occurrence of pathogenic Yersinia enterocolitica in Norwegian pork products determined by a PCR method and a traditional culturing method
    G S Johannessen
    National Veterinary Institute, Oslo, Norway
    Int J Food Microbiol 54:75-80. 2000
    From October 1997 to April 1998, a survey was conducted to assess the occurrence of pathogenic Yersinia enterocolitica in Norwegian pork products, using a traditional culturing method and a PCR assay...
  78. ncbi The ail gene is present in some Yersinia enterocolitica biotype 1A strains
    Leila M Sihvonen
    Bacteriology Unit, National Institute for Health and Welfare THL, Helsinki, Finland
    Foodborne Pathog Dis 8:455-7. 2011
    ..Here, we report two Yersinia enterocolitica biotype 1A strains that are usually nonpathogenic and carry the ail gene...
  79. ncbi Familial outbreak of Yersinia enterocolitica serotype O9 biotype 2
    Shoji Moriki
    Clinical and Laboratory Medicine, Shimane University Hospital, Izumo, Shimane, Japan
    J Infect Chemother 16:56-8. 2010
    In Japan, infection with Yersinia enterocolitica of the pathogenic serobiogroup serotype O9 biotype 2 (O9/2) has rarely occurred, and familial outbreaks of Y. enterocolitica are also infrequently reported...
  80. ncbi The cytotoxin YopT of Yersinia enterocolitica induces modification and cellular redistribution of the small GTP-binding protein RhoA
    R Zumbihl
    Max von Pettenkofer Institut für Hygiene und Mikrobiologie, Pettenkoferstrasse 9a, 80336 Munich, Germany
    J Biol Chem 274:29289-93. 1999
    Pathogenic Yersinia enterocolitica produces two virulence plasmid-encoded cytotoxins, YopE and YopT, that are translocated into target cells where they disrupt the actin cytoskeleton. Here we show that infection of cells with wild type Y...
  81. ncbi Contamination of carcasses, offals, and the environment with yadA-positive Yersinia enterocolitica in a pig slaughterhouse
    M Fredriksson-Ahomaa
    Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, University of Helsinki, Finland
    J Food Prot 63:31-5. 2000
    ..study was carried out in order to evaluate the contamination of the pig-slaughtering line with pathogenic Yersinia enterocolitica carrying the yadA gene...
  82. pmc Use of a single procedure for selective enrichment, isolation, and identification of plasmid-bearing virulent Yersinia enterocolitica of various serotypes from pork samples
    S Bhaduri
    Microbial Food Safety Research Unit, U S Department of Agriculture, Wyndmoor, Pennsylvania 19038, USA
    Appl Environ Microbiol 63:1657-60. 1997
    Many selective enrichment methods for the isolation of Yersinia enterocolitica from foods have been described...
  83. ncbi Regulation of the phage-shock-protein stress response in Yersinia enterocolitica
    Andrew J Darwin
    Department of Microbiology, New York University School of Medicine, New York, USA
    Adv Exp Med Biol 603:167-77. 2007
    The phage-shock-protein (Psp) system of Yersinia enterocolitica encodes a stress response that is essential for viability when the secretin component of its Ysc type III secretion system is produced...
  84. ncbi Structure of the type III secretion recognition protein YscU from Yersinia enterocolitica
    Ulrich Wiesand
    Division of Structural Biology, Helmholtz Centre for Infection Research HZI, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    J Mol Biol 385:854-66. 2009
    The inner-membrane protein YscU has an important role during the assembly of the Yersinia enterocolitica type III secretion injectisome...
  85. ncbi Yersinia enterocolitica 16S rRNA gene types belong to the same genospecies but form three homology groups
    H Neubauer
    Institute of Microbiology, German Armed Forces Medical Academy, Munchen
    Int J Med Microbiol 290:61-4. 2000
    ..Based on different DNA-DNA hybridization values and the 16S rRNA gene sequences a division into two Yersinia enterocolitica subspecies is justified. We propose the names Yersinia enterocolitica subsp...
  86. ncbi The YompC protein of Yersinia enterocolitica: molecular and physiological characterization
    K Brzostek
    Department of Applied Microbiology, Institute of Microbiology, Warsaw University, 02 096 Warsaw, Poland
    Folia Microbiol (Praha) 52:73-80. 2007
    The structural gene coding for YompC has been identified in the genome of a pathogenic strain of Yersinia enterocolitica O:9, and was subsequently cloned and sequenced...
  87. pmc Salmonella enterica serovar Typhimurium can detect acyl homoserine lactone production by Yersinia enterocolitica in mice
    Jessica L Dyszel
    Department of Microbiology, Ohio State University, 484 West 12th Ave, 376 Biological Sciences Building, Columbus, OH 43210, USA
    J Bacteriol 192:29-37. 2010
    ..Typhimurium through mice infected with the AHL-producing pathogen Yersinia enterocolitica. SdiA is not activated during transit through mice infected with a yenI mutant of Y...
  88. ncbi The psychrotrophic bacterium Yersinia enterocolitica requires expression of pnp, the gene for polynucleotide phosphorylase, for growth at low temperature (5 degrees C)
    R L Goverde
    University of Utrecht, Faculty of Veterinary Medicine, Department of the Science of Food of Animal Origin, The Netherlands
    Mol Microbiol 28:555-69. 1998
    The psychrotrophic bacterium Yersinia enterocolitica is characterized by temperature-dependent adaptations. To investigate Y...
  89. pmc Real-time PCR method for detection of pathogenic Yersinia enterocolitica in food
    S Thisted Lambertz
    National Food Administration Research and Development Department, PO Box 622, SE 751 26 Uppsala, Sweden
    Appl Environ Microbiol 74:6060-7. 2008
    The current methods for the detection of pathogenic Yersinia enterocolitica bacteria in food are time consuming and inefficient...
  90. pmc Structure and electrophysiological properties of the YscC secretin from the type III secretion system of Yersinia enterocolitica
    Peter Burghout
    Department of Molecular Microbiology and Institute of Biomembranes, Utrecht University, Utrecht, The Netherlands
    J Bacteriol 186:4645-54. 2004
    YscC is the integral outer membrane component of the type III protein secretion machinery of Yersinia enterocolitica and belongs to the family of secretins...
  91. ncbi Invasin and beyond: regulation of Yersinia virulence by RovA
    Damon W Ellison
    Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8230, St Louis, MO 63110, USA
    Trends Microbiol 12:296-300. 2004
    ..transcription factors, regulates expression of invasin, the major adhesion and invasion factor in Yersinia enterocolitica and Yersinia pseudotuberculosis...
  92. ncbi Identification of rpoE and nadB as host responsive elements of Yersinia enterocolitica
    Gerhard Heusipp
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    FEMS Microbiol Lett 226:291-8. 2003
    We describe the identification of the Yersinia enterocolitica rpoE gene, which encodes the alternative sigma factor sigmaE, and the divergently transcribed nadB gene, as genes that are expressed during infection of mice...
  93. ncbi Growth phase and low pH affect the thermal regulation of the Yersinia enterocolitica inv gene
    J C Pepe
    Department of Microbiology and Molecular Genetics, University of California at Los Angeles 90024 1489
    Mol Microbiol 11:123-35. 1994
    The inv gene encodes the protein invasin, which is the primary invasion factor for Yersinia enterocolitica in vitro and in vivo...
  94. ncbi Molecular typing and virulence markers of Yersinia enterocolitica strains from human, animal and food origins isolated between 1968 and 2000 in Brazil
    Juliana P Falcão
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto USP, Av do Cafe S N, Campus Universitário USP, Ribeirao Preto, SP 14040 903, Brazil
    J Med Microbiol 55:1539-48. 2006
    ..typing and virulence markers were used to evaluate the genetic profiles and virulence potential of 106 Yersinia enterocolitica strains...
  95. ncbi The outer membrane component, YscC, of the Yop secretion machinery of Yersinia enterocolitica forms a ring-shaped multimeric complex
    M Koster
    Microbial Pathogenesis Unit, International Institute of Cellular and Molecular Pathology and Faculté de Médecine, Universite Catholique de Louvain, Brussels, Belgium
    Mol Microbiol 26:789-97. 1997
    The YscC protein of Yersinia enterocolitica is essential for the secretion of anti-host factors, called Yops, into the extracellular environment...
  96. ncbi Gene array analysis of Yersinia enterocolitica FlhD and FlhC: regulation of enzymes affecting synthesis and degradation of carbamoylphosphate
    Vinayak Kapatral
    Integrated Genomics, Inc, 2201 West Campbell Park Dr, Chicago, IL 60612, USA
    Microbiology 150:2289-300. 2004
    This paper focuses on global gene regulation by FlhD/FlhC in enteric bacteria. Even though Yersinia enterocolitica FlhD/FlhC can complement an Escherichia coli flhDC mutant for motility, it is not known if the Y...
  97. ncbi Temperature-dependent regulation of Yersinia enterocolitica Class III flagellar genes
    V Kapatral
    Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow 83843, USA
    Mol Microbiol 19:1061-71. 1996
    Temperature is a key environmental cue for Yersinia enterocolitica as well as for the two other closely related pathogens, Yersinia pestis and Yersinia pseudotuberculosis. Between the range of 30 degrees C and 37 degrees C, Y...
  98. pmc Quorum sensing in Yersinia enterocolitica controls swimming and swarming motility
    Steve Atkinson
    Institute of Infections, Immunity and Inflammation, Centre for Biomolecular Science, University of Nottingham, Nottingham NG7 2RD, United Kingdom
    J Bacteriol 188:1451-61. 2006
    The Yersinia enterocolitica LuxI homologue YenI directs the synthesis of N-3-(oxohexanoyl)homoserine lactone (3-oxo-C6-HSL) and N-hexanoylhomoserine lactone (C6-HSL). In a Y...
  99. pmc Bacteriophage phiYeO3-12, specific for Yersinia enterocolitica serotype O:3, is related to coliphages T3 and T7
    M Pajunen
    Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, University of Turku, Finland
    J Bacteriol 182:5114-20. 2000
    Bacteriophage phiYeO3-12 is a lytic phage of Yersinia enterocolitica serotype O:3. The phage receptor is the lipopolysaccharide O chain of this serotype that consists of the rare sugar 6-deoxy-L-altropyranose...
  100. ncbi Interaction of Yersinia enterocolitica with epithelial cells: invasin beyond invasion
    Guntram A Grassl
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Universitatsklinikum Tubingen, Elfriede Aulhorn Str 6, D 72076 Tubingen, Germany
    Int J Med Microbiol 293:41-54. 2003
    ..is an outer membrane protein that is functionally expressed in the enteropathogenic Yersinia species Yersinia enterocolitica and Yersinia pseudotuberculosis...
  101. ncbi The needle length of bacterial injectisomes is determined by a molecular ruler
    Laure Journet
    Biozentrum, Universitat Basel, 4056 Basel, Switzerland
    Science 302:1757-60. 2003
    ..Here, we provide evidence that the length of this needle is determined by the size of a protein, YscP, acting as a molecular ruler...

Research Grants46

  1. Fatty acid related regulation of enteric infectious disease
    FREDRICK JON KULL; Fiscal Year: 2012
    ..several types of Escherichia coli, Salmonella typhi, Salmonella typhimurium, Shigella flexneri, and Yersinia enterocolitica, contain A/X regulators with homologous positively charged residues and ligand binding pockets...
  2. A. L. lactis-based vaccine for children with broad spectrum for enteric pathogens
    Wendy L Picking; Fiscal Year: 2013
    ..pediatric vaccine against Category B Biodefense food and water borne pathogens: Shigella, Salmonella and Yersinia enterocolitica. Newborns, infants and young children are among the most vulnerable groups of the population who may not ..
  3. Pathogen-Specific Regulation of Protein Assembly
    ALLEN BERNARD REITZ; Fiscal Year: 2010
    ..three compounds that block the PBGS, essential for life, in the NIAID Category B priority pathogen Yersinia enterocolitica, but not human PBGS, and are active in a Y. enterocolitica zone inhibition assay...
  4. Multiplexed Detection of Food and Waterborne Pathogens
    Francis Barany; Fiscal Year: 2011
    ..multiplexed and nested PCR/LDR assays to identify Category B bacterial pathogens (Campylocbacter jejuni, Yersinia enterocolitica, Salmonella spp, Shigella spp, Diarrheagenic E. coli, Pathogenic Vibrio spp, and Listeria monocytogenes)...
  5. Regulation of Pore Formation by Type III Secretion System
    Gloria I Viboud; Fiscal Year: 2010
    ..Some of these organisms include important entropathogens such as Salmonella spp., Shigella spp., Yersinia enterocolitica, Y...
  6. RovA regulon and virulence of Yersinia enterocolitica
    Virginia L Miller; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Yersinia enterocolitica is a Gram-negative pathogen responsible for a range of clinical syndromes but is primarily associated with gastrointestinal disorders...
  7. Molecular interactions: oral bacteria & matrix proteins
    Keith Mintz; Fiscal Year: 2010
    ..is structurally related to YadA, a multipurpose ECM protein adhesin of the enteropathogenic bacterium Yersinia enterocolitica, and is associated with bacterial cell surface appendages...
  8. The developing intestinal immune system in Yersinia enterocolitica infection
    REBECCA D ADKINS; Fiscal Year: 2010
    ..period, we have developed a novel murine model of orogastric infection with the extracellular bacterium Yersinia enterocolitica. Strikingly, neonates are markedly more resistant than adults to this enteropathogen, an observation ..
  9. INTERACTIONS BETWEEN AGROBACTERIUM AND HOST PLANTS
    Stephen C Winans; Fiscal Year: 2010
    ..regulate many genes on several chromosomes and plasmid of this bacterium, while Yenl and YenR of Yersinia enterocolitica regulate an unknown number of genes, including yenS, which appears to encode a small regulatory RNA...
  10. The Psp response of Yersinia enterocolitica
    Andrew J Darwin; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The bacterium Yersinia enterocolitica causes human gastroenteritis, and is closely related to the causative agent of Plague, Y. pestis...
  11. Development of Novel Antimicrobial Peptide Mimics
    Paul B Savage; Fiscal Year: 2011
    ..coli, Vibrios, Salmonella, Listeria monocytogenes, Campylobacteria jejuni and Yersinia enterocolitica (all Category B Pathogens)...
  12. Salmonella polymicrobial interactions
    BRIAN M AHMER; Fiscal Year: 2012
    ..To date, we have determined that Salmonella can detect Aeromonas hydrophila in turtles and Yersinia enterocolitica in mice and pigs...
  13. Role of TRIF-dependent TLR signaling in intestinal immunity
    Masayuki Fukata; Fiscal Year: 2013
    ..Using Yersinia enterocolitica as a model enteric pathogen, we found that TRIF-deficient mice had a significant defect in macrophage ..
  14. Targeting bacterial phosphatases for novel anti-bacterial agents.
    Maurizio Pellecchia; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Yersinia pestis, Salmonella enterica, and Yersinia enterocolitica use a number of toxins to evade the immune system one of which is the protein tyrosine phosphatase YopH...
  15. Role of TRIF-dependent TLR signaling in intestinal immunity
    Masayuki Fukata; Fiscal Year: 2011
    ..Using Yersinia enterocolitica as a model enteric pathogen, we found that TRIF-deficient mice had a significant defect in macrophage ..
  16. Siderophore Biosynthesis Inhibitors as New Antibiotics for Biodefense
    Derek S Tan; Fiscal Year: 2010
    ..are NIAID Priority Pathogens for biodefense research: Yersinia pestis, the causative agent of plague, and Yersinia enterocolitica, a gastroenteritic water- and foodborne pathogen...
  17. Spatial Control of Host Cell Signaling by a Bacterial Pathogen
    GREGORY THOMAS CRIMMINS; Fiscal Year: 2012
    ..species that caused the Black Plague and the gastro-intestinal pathogens Yersinia pseudotuberculosis and Yersinia enterocolitica, all share a common factor that they inject into their mammalian host...
  18. The impact of TLR1 on dysbiosis and intestinal inflammation
    RANDY WILLIAM DEPAOLO; Fiscal Year: 2013
    ..examine the cause of dysbiosis in the absence of TLR1-signaling after infection by the enteropathogen, Yersinia enterocolitica. The project will look to identify host factors, pathogenic strategies and the contribution of commensal ..
  19. Bacterial Pathogen Amplification & Real-Time Detection
    JACK U REN; Fiscal Year: 2003
    ..cholera, Shigella dysentery, Salmonella species, Listeria monocytogenes, Camphylobacter jejuni, and Yersinia enterocolitica will be detected in this program...
  20. Hexameric PBGS as a Bioterrorism Defense
    Eileen Jaffe; Fiscal Year: 2006
    ..pseudomallei, Brucella mefitensis, Burkholderia mallei, Rickettsia prowazekii, Vibrio cholerae, and Yersinia enterocolitica. The aims of this exploratory proposal are: 1) To build protein structure models for hexamers of PBGS ..
  21. Y ENTEROCOLITICA VIRULENCE PLASMID
    John Morris; Fiscal Year: 1991
    b>Yersinia enterocolitica has been implicated as a significant cause of enteritis and enterocolitis, may cause mesenteric adenitis, hepatosplenic abcesses, and septicemia. Virulence of Y...
  22. IMMUNOPATHOLOGY OF CHLAMYDIA--INDUCED REACTIVE ARTHRITIS
    Roger Rank; Fiscal Year: 1991
    Reactive arthritis has been found to result from gastrointestinal infections with Yersinia enterocolitica, Salmonella, Shigella, and Campylobacter and from genital tract infections with Chlamydia trachomatis...
  23. The Type III Pathway of Yersinia Pestis
    Olaf Schneewind; Fiscal Year: 2004
    The human pathogen Yersinia pestis, as well as its close relatives Yersinia pseudotuberculosis and Yersinia enterocolitica, employ a virulence plasmid-encoded type Ill secretion pathway to escape phagocytic killing during host infection...
  24. NOVEL VIRULENCE GENES OF YERSINIA
    VIRGINIA MILLER; Fiscal Year: 2003
    DESCRIPTION (Adapted from the Applicant's Abstract): Yersinia enterocolitica causes a variety of gastrointestinal syndromes; systemic spread of the organism frequently occurs in immunocompromised individuals and has a mortality rate of ..
  25. YsrRS regulon of Y. enterocolitica
    VIRGINIA MILLER; Fiscal Year: 2009
    b>Yersinia enterocolitica is one of three pathogenic species of the genus Yersinia. It is responsible for disease symptoms ranging from a mild gastroenteritis to systemic infection, which is often fatal...
  26. IMMUNE RESPONSES TO YERSINIA IN THYROID DISEASE
    Louis Shenkman; Fiscal Year: 1980
    ..have revealed that patients with thyroid disease have a significantly higher pervalence of antibodies to Yersinia enterocolitica than do controls. Studies outlined in this proposal are directed at elucidating this association...
  27. MOLECULAR MIMICRY BETWEEN Y ENTEROCOLITICS AND TSHR
    Bellur Prabhakar; Fiscal Year: 2001
    ..that there is molecular mimicry between a chromosomally encoded low molecular weight protein (LP) of Yersinia enterocolitica and the thyrotropin receptor...
  28. STRESS/BACTERIAL INTERACTIONS IN INFECTIOUS DISEASE
    Mark Lyte; Fiscal Year: 2000
    ..in mice to infectious oral challenge with the primary model of human bacterial invasiveness, Yersinia enterocolitica. The second Specific Aim will examine the in vitro molecular mechanisms by which catecholamines influence ..
  29. INVASION FACTORS OF YERSINIA ENTEROCOLITICA
    VIRGINIA MILLER; Fiscal Year: 2001
    ..She proposes to identify and characterize this regulator and how it affects inv expression. If time permits, she also hopes to do preliminary studies to investigate the association of Ye with macrophages in vivo. ..
  30. RESEARCH CAREER ENHANCEMENT PROGRAM
    DANA DIEDRICH; Fiscal Year: 1993
    ..to proteins; Studies on the molecular basis of regulon repression in the facultative parasite Yersinia enterocolitica; Saccharomyces cerevisiae as a model to test the prediction that allele variants will have negligible ..
  31. VALIDATION TEST FOR PATHOGEN INACTIVATION USING THE PCR
    Lily Lin; Fiscal Year: 1993
    ..the inactivation of additional pathogens in platelet concentrates, including HIV-1, HBV, HCV, CMV and Yersinia enterocolitica, without affecting in vitro platelet function...
  32. YSA locus of high-virulent Yersinia enterocolitica
    GLENN YOUNG; Fiscal Year: 2003
    ..enterocolitica maintain two contact-dependent TTSS systems, each of which transports a defined set of proteins and each of which is under separate control. ..
  33. TITLE OMITTED
    Lawrence Johnson; Fiscal Year: 1991
    ..Additional pathogens under study include: Salmonella typhimurium, Yersinia enterocolitica, Pneumococcus pneumoniae and Toxoplasma gondii...
  34. Role of IL-1 in Yersinia Induced Intestinal Inflammation
    Peter Dube; Fiscal Year: 2002
    b>Yersinia enterocolitica infection is a food born pathogen that causes severe intestinal inflammation. Recently a regulator was cloned, rovA, that does not cause severe intestinal inflammation...
  35. EXPERIMENTAL PATHOLOGY SHARED RESOURCE LABORATORY
    Laura Lamps; Fiscal Year: 2003
    ..abstract_text> ..
  36. RovA regulon of Yersinia pestis
    VIRGINIA MILLER; Fiscal Year: 2003
    ..pestis, and (2) Identification of the Y. pestis RovA regulated gene products; we predict some of these rovA regulated genes will be unique to Y. pestis (compared to Y. enterocolitica or Salmonella). ..
  37. Autotransporter proteins and virulence of Y. pestis
    VIRGINIA MILLER; Fiscal Year: 2006
    ..Functional analysis of the Yaps. We will begin to investigate the function of the Yaps by testing E. coli expressing individual Yaps for a variety of known functions previously associated with autotransporter proteins. ..
  38. The Psp response of Yersinia enterocolitica
    Andrew Darwin; Fiscal Year: 2008
    ..Therefore, by understanding the Psp system we will gain further insight into the essential ability of bacteria to respond to stressful conditions that occur during host infection. ..
  39. STAPHYLOCOCCUS AUREUS FIBRONECTIN-BINDING ADHESINS
    Barbara Menzies; Fiscal Year: 2003
    ..The use of FnBP as an anti-adhesin presents a novel therapeutic tool for the prevention of S. aureus infections. ..
  40. Identifying targets for diagnosing oral candidiasis
    David Schofield; Fiscal Year: 2005
    ..Since Candida species are the most important fungal pathogen of the oral cavity, the rapid and accurate diagnosis of oral candidiasis using novel disease biomarkers will significantly improve oral health. ..
  41. Regulation of murine neonatal Th2 function
    REBECCA D ADKINS; Fiscal Year: 2010
    ..This idea is supported by our findings that the function of peripheral CD4+ cells in neonates resembles that of RTE in adults. ..
  42. Food Safety Task Force Conference
    Timothy Jones; Fiscal Year: 2005
    ..Abstract Not Provided ..
  43. The cAMP regulatory system of pathogenic Yersinia
    GLENN YOUNG; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..