shigella

Summary

Summary: A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that ferments sugar without gas production. Its organisms are intestinal pathogens of man and other primates and cause bacillary dysentery (DYSENTERY, BACILLARY).

Top Publications

  1. ncbi Shigella type III secretion effectors: how, where, when, for what purposes?
    Claude Parsot
    Institut Pasteur, Unite de Pathogenie Microbienne Moleculaire, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Curr Opin Microbiol 12:110-6. 2009
  2. ncbi Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet
    Efrain M Ribot
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Foodborne Pathog Dis 3:59-67. 2006
  3. ncbi Shigellosis
    Swapan Kumar Niyogi
    National Institute of Cholera and Enteric Diseases P 33, C I T Road, Scheme XM, Beliaghata Kolkata 700 010, India
    J Microbiol 43:133-43. 2005
  4. pmc Whole-genome phylogeny of Escherichia coli/Shigella group by feature frequency profiles (FFPs)
    Gregory E Sims
    Department of Informatics, J Craig Venter Institute, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 108:8329-34. 2011
  5. pmc Phenylbutyrate counteracts Shigella mediated downregulation of cathelicidin in rabbit lung and intestinal epithelia: a potential therapeutic strategy
    Protim Sarker
    International Centre for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh
    PLoS ONE 6:e20637. 2011
  6. ncbi Involvement of FIS in the H-NS-mediated regulation of virF gene of Shigella and enteroinvasive Escherichia coli
    M Falconi
    Laboratorio di Genetica, Dipartimento di Biologia MCA, , 62032 Camerino (MC, Italy
    Mol Microbiol 42:439-52. 2001
  7. ncbi Structure and genetics of Shigella O antigens
    Bin Liu
    TEDA School of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, China
    FEMS Microbiol Rev 32:627-53. 2008
  8. ncbi Shigella are versatile mucosal pathogens that circumvent the host innate immune system
    Hiroshi Ashida
    Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Curr Opin Immunol 23:448-55. 2011
  9. pmc Decrease in shigellosis-related deaths without Shigella spp.-specific interventions, Asia
    Pradip Bardhan
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Emerg Infect Dis 16:1718-23. 2010
  10. ncbi Study of polymorphic variable-number of tandem repeats loci in the ECOR collection and in a set of pathogenic Escherichia coli and Shigella isolates for use in a genotyping assay
    Bjørn Arne Lindstedt
    Norwegian Institute of Public Health, Division for Infectious Diseases Control, N 0403 Oslo, Norway
    J Microbiol Methods 69:197-205. 2007

Detail Information

Publications289 found, 100 shown here

  1. ncbi Shigella type III secretion effectors: how, where, when, for what purposes?
    Claude Parsot
    Institut Pasteur, Unite de Pathogenie Microbienne Moleculaire, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Curr Opin Microbiol 12:110-6. 2009
    Bacteria of Shigella spp., the causative agents of shigellosis in humans, possess a repertoire of approximately 25-30 effectors injected into host cells by a type III secretion apparatus (T3SA)...
  2. ncbi Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet
    Efrain M Ribot
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Foodborne Pathog Dis 3:59-67. 2006
    ..gel electrophoresis (PFGE) protocols for the subtyping of Escherichia coli O157:H7, Salmonella serotypes, and Shigella species are described...
  3. ncbi Shigellosis
    Swapan Kumar Niyogi
    National Institute of Cholera and Enteric Diseases P 33, C I T Road, Scheme XM, Beliaghata Kolkata 700 010, India
    J Microbiol 43:133-43. 2005
    Shigellosis is a global human health problem. Four species of Shigella i.e. S. dysenteriae, S. flexneri, S. boydii and S. sonnei are able to cause the disease...
  4. pmc Whole-genome phylogeny of Escherichia coli/Shigella group by feature frequency profiles (FFPs)
    Gregory E Sims
    Department of Informatics, J Craig Venter Institute, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 108:8329-34. 2011
    A whole-genome phylogeny of the Escherichia coli/Shigella group was constructed by using the feature frequency profile (FFP) method...
  5. pmc Phenylbutyrate counteracts Shigella mediated downregulation of cathelicidin in rabbit lung and intestinal epithelia: a potential therapeutic strategy
    Protim Sarker
    International Centre for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh
    PLoS ONE 6:e20637. 2011
    ..Oral treatment of Shigella infected rabbits with sodium butyrate (NaB) reduces clinical severity and counteracts the downregulation of ..
  6. ncbi Involvement of FIS in the H-NS-mediated regulation of virF gene of Shigella and enteroinvasive Escherichia coli
    M Falconi
    Laboratorio di Genetica, Dipartimento di Biologia MCA, , 62032 Camerino (MC, Italy
    Mol Microbiol 42:439-52. 2001
    The mechanism of pathogenicity in Shigella and enteroinvasive Escherichia coli (EIEC) requires the co-ordinated expression of several genes located on both the virulence plasmid and the chromosome...
  7. ncbi Structure and genetics of Shigella O antigens
    Bin Liu
    TEDA School of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, China
    FEMS Microbiol Rev 32:627-53. 2008
    This review covers the O antigens of the 46 serotypes of Shigella, but those of most Shigella flexneri are variants of one basic structure, leaving 34 Shigella distinct O antigens to review, together with their gene clusters...
  8. ncbi Shigella are versatile mucosal pathogens that circumvent the host innate immune system
    Hiroshi Ashida
    Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Curr Opin Immunol 23:448-55. 2011
    ..Here we review current topics on host defense mechanisms against bacterial infection and the countermeasures that Shigella use to evade the innate immune system.
  9. pmc Decrease in shigellosis-related deaths without Shigella spp.-specific interventions, Asia
    Pradip Bardhan
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Emerg Infect Dis 16:1718-23. 2010
    ..b>Shigella spp.-related deaths decreased substantially during a period without Shigella spp.-specific interventions...
  10. ncbi Study of polymorphic variable-number of tandem repeats loci in the ECOR collection and in a set of pathogenic Escherichia coli and Shigella isolates for use in a genotyping assay
    Bjørn Arne Lindstedt
    Norwegian Institute of Public Health, Division for Infectious Diseases Control, N 0403 Oslo, Norway
    J Microbiol Methods 69:197-205. 2007
    ..A set of 61 pathogenic isolates of both E. coli and Shigella spp. was then tested with the same set of VNTR loci, and revealed 54 distinct genotypes...
  11. pmc Within-species lateral genetic transfer and the evolution of transcriptional regulation in Escherichia coli and Shigella
    Elizabeth Skippington
    The University of Queensland, Institute for Molecular Bioscience and Australian Research Council Centre of Excellence in Bioinformatics, Brisbane, Queensland 4072, Australia
    BMC Genomics 12:532. 2011
    ..methods to investigate the relationship between units of lateral transfer and recombination within the Escherichia coli - Shigella clade and the topological properties of genes in the E. coli transcriptional regulatory network (TRN).
  12. pmc Detection of Shigella by a PCR assay targeting the ipaH gene suggests increased prevalence of shigellosis in Nha Trang, Vietnam
    Dinh Thiem Vu
    National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
    J Clin Microbiol 42:2031-5. 2004
    b>Shigella spp. are exquisitely fastidious gram-negative organisms which frequently escape detection by traditional culture methods...
  13. pmc Cleavage of Shigella surface protein VirG occurs at a specific site, but the secretion is not essential for intracellular spreading
    I Fukuda
    Department of Bacteriology, University of Tokyo, Japan
    J Bacteriol 177:1719-26. 1995
    The large plasmid-encoded outer membrane protein VirG (IcsA) of Shigella flexneri is essential for bacterial spreading by eliciting polar deposition of filamentous actin (F-actin) in the cytoplasm of epithelial cells...
  14. pmc Shigella: a model of virulence regulation in vivo
    Benoit Marteyn
    Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, Paris, France
    Gut Microbes 3:104-20. 2012
    Much is known about the molecular effectors of pathogenicity of gram-negative enteric pathogens, among which Shigella can be considered a model...
  15. ncbi Extended-spectrum beta-lactamase-mediated third-generation cephalosporin resistance in Shigella isolates in Bangladesh
    Mahbubur Rahman
    J Antimicrob Chemother 54:846-7. 2004
  16. pmc Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard road
    Myron M Levine
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Nat Rev Microbiol 5:540-53. 2007
    More than 50 years of research has yielded numerous Shigella vaccine candidates that have exemplified both the promise of vaccine-induced prevention of shigellosis and the impediments to developing a safe and effective vaccine for ..
  17. ncbi The molecular evolutionary history of Shigella spp. and enteroinvasive Escherichia coli
    Junping Peng
    State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing 100730, China
    Infect Genet Evol 9:147-52. 2009
    Shigellosis, which caused by Shigella and enteroinvasive Escherichia coli (EIEC), was still a threat to public health. Compelling evidence indicates that Shigella species and EIEC are derived from multiple origins of E...
  18. pmc Lytic and lysogenic infection of diverse Escherichia coli and Shigella strains with a verocytotoxigenic bacteriophage
    C E James
    School of Biological Sciences, University of Liverpool, Liverpool, L69 7ZB, United Kingdom
    Appl Environ Microbiol 67:4335-7. 2001
    ..A number of Shigella and E. coli strains were susceptible to lysogenic infection, and a smooth E...
  19. pmc Estimating the burden of shigellosis in Thailand: 36-month population-based surveillance study
    Pornthip Chompook
    Chiang Rai Regional Hospital, Chiang Rai Province, Ministry of Public Health, Thailand
    Bull World Health Organ 83:739-46. 2005
    ..To estimate incidence of shigellosis in the Kaengkhoi district, Saraburi Province, Thailand...
  20. pmc High prevalence of antimicrobial resistance among Shigella isolates in the United States tested by the National Antimicrobial Resistance Monitoring System from 1999 to 2002
    Sumathi Sivapalasingam
    Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Antimicrob Agents Chemother 50:49-54. 2006
    b>Shigella spp. infect approximately 450,000 persons annually in the United States, resulting in over 6,000 hospitalizations...
  21. ncbi Capping of actin filaments by vinculin activated by the Shigella IpaA carboxyl-terminal domain
    Nalini Ramarao
    Unite de Pathogenie Microbienne Moleculaire, INSERM U786, Institut Pasteur, 75724 Paris Cedex 15, France
    FEBS Lett 581:853-7. 2007
    b>Shigella, the causative agent of bacillary dysentery, invades epithelial cells...
  22. pmc Laboratory surveillance of bacterial gastroenteric pathogens in The Netherlands, 1991-2001
    W van Pelt
    Department of Infectious Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Epidemiol Infect 130:431-41. 2003
    ..Reported rates of Shigella spp. and Yersinia spp. varied little, with average annual incidences of 3.2 and 1...
  23. ncbi Shigella's ways of manipulating the host intestinal innate and adaptive immune system: a tool box for survival?
    Armelle Phalipon
    Unite de Pathogenie Microbienne Moleculaire, INSERM U786, Institut Pasteur 25, rue du Dr Roux, Paris, France
    Immunol Cell Biol 85:119-29. 2007
    b>Shigella, a Gram-negative invasive enteropathogenic bacterium, causes the rupture, invasion and inflammatory destruction of the human colonic epithelium. This complex and aggressive process accounts for the symptoms of bacillary dysentery...
  24. pmc Reduced selection leads to accelerated gene loss in Shigella
    Ruth Hershberg
    Department of Biological Sciences, Stanford University, Serra Mall, Stanford, CA 94305, USA
    Genome Biol 8:R164. 2007
    ..It was suggested that the increased gene loss in obligate pathogens may be due to a reduction in the effectiveness of purifying selection. Less attention has been given to the causes of increased gene loss in facultative pathogens...
  25. pmc Actin-based motility of intracellular microbial pathogens
    M B Goldberg
    Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Microbiol Mol Biol Rev 65:595-626, table of contents. 2001
    A diverse group of intracellular microorganisms, including Listeria monocytogenes, Shigella spp., Rickettsia spp., and vaccinia virus, utilize actin-based motility to move within and spread between mammalian host cells...
  26. ncbi Shigella targets epithelial tricellular junctions and uses a noncanonical clathrin-dependent endocytic pathway to spread between cells
    Makoto Fukumatsu
    Department of Infectious Disease Control, International Research Center for Infectious Disease, University of Tokyo, Shirokanedai, Minato ku, Tokyo, Japan
    Cell Host Microbe 11:325-36. 2012
    ..We show that during cell-to-cell movement, Shigella-containing pseudopodia target epithelial tricellular junctions, the contact point where three epithelial cells ..
  27. ncbi Development of a duplex real-time PCR for differentiation between E. coli and Shigella spp
    M Pavlovic
    Bavarian Health and Food Safety Authority, Oberschleissheim, Germany
    J Appl Microbiol 110:1245-51. 2011
    The aim of this study was to develop a real-time PCR test for differentiation between Shigella spp. and E. coli, in particular enteroinvasive Escherichia coli (EIEC).
  28. ncbi The virF promoter in Shigella: more than just a curved DNA stretch
    Gianni Prosseda
    Dip Biologia Cellulare e dello Sviluppo, University La Sapienza, 00185 Roma, Italy
    Mol Microbiol 51:523-37. 2004
    In the human enteropathogen Shigella transcription of virF, the primary regulator of the invasion functions, is strictly temperature-dependent and is antagonistically mediated by H-NS and FIS, which bind to specific sites on the virF ..
  29. pmc Detection of intra-familial transmission of shigella infection using conventional serotyping and pulsed-field gel electrophoresis
    A I Khan
    Clinical Sciences Division, ICDDR, B Centre for Health and Population Research, Dhaka, Bangladesh
    Epidemiol Infect 134:605-11. 2006
    ..Our objective was to evaluate the intra-familial transmission of shigella infection using PFGE...
  30. ncbi Antimicrobial-resistant Shigella infections from Iran: an overlooked problem?
    Mercedeh Tajbakhsh
    Research Center for Gastroenterology and Liver Disease, Shahid Beheshti University, Medical Sciences, Tehran, Iran
    J Antimicrob Chemother 67:1128-33. 2012
    ..to assess the level of antimicrobial resistance, the presence of genes encoding resistance to cephalosporins and plasmid-mediated quinolone resistance (PMQR), and genetic relatedness among Shigella isolates obtained from Iranian patients.
  31. ncbi Emergence of CTX-M-type beta-lactam resistance in Shigella spp. in Hong Kong
    Terence Kin Man Cheung
    Int J Antimicrob Agents 25:350-2. 2005
  32. pmc A multi-center randomized trial to assess the efficacy of gatifloxacin versus ciprofloxacin for the treatment of shigellosis in Vietnamese children
    Ha Vinh
    The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS Negl Trop Dis 5:e1264. 2011
    The bacterial genus Shigella is the leading cause of dysentery. There have been significant increases in the proportion of Shigella isolated that demonstrate resistance to nalidixic acid...
  33. pmc Detection of virulence genes in Malaysian Shigella species by multiplex PCR assay
    Kwai Lin Thong
    Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    BMC Infect Dis 5:8. 2005
    In Malaysia, Shigella spp. was reported to be the third commonest bacterial agent responsible for childhood diarrhoea...
  34. pmc Gene decay in Shigella as an incipient stage of host-adaptation
    Ye Feng
    Genomics Research Center, Harbin Medical University, Harbin, China
    PLoS ONE 6:e27754. 2011
    ..b>Shigella, the causative agents of human shigellosis, have arisen from different E...
  35. ncbi Frequency of isolation of various subtypes and antimicrobial resistance of Shigella from urban slums of Karachi, Pakistan
    Afia Zafar
    Department of Pathology and Microbiology, Aga Khan University Hospitals, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    Int J Infect Dis 13:668-72. 2009
    ..Therefore we conducted a prospective study to determine the frequency of isolation of Shigella serotypes and antimicrobial resistance.
  36. ncbi Liquid chromatography/mass spectrometry characterization of Escherichia coli and Shigella species
    Robert A Everley
    Division of Consolidated Laboratory Services, Commonwealth of Virginia, and Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23219, USA
    J Am Soc Mass Spectrom 19:1621-8. 2008
    ..LC/QTOF MS) utilizing electrospray ionization was employed to monitor protein expression in Escherichia coli and Shigella organisms. Comparison with MALDI/TOF-MS revealed more proteins, particularly above 15 kDa...
  37. pmc Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic
    Rubhana Raqib
    International Centre for Diarrhoeal Disease Research Bangladesh, Centre for Health and Population Research, Dhaka 1212, Bangladesh
    Proc Natl Acad Sci U S A 103:9178-83. 2006
    b>Shigella is a major cause of morbidity, mortality, and growth retardation for children in developing countries. Emergence of antibiotic resistance among Shigellae demands the development of effective medicines...
  38. ncbi Shigella targets the mitochondrial checkpoint of programmed necrosis
    Lorenzo Galluzzi
    INSERM, U848, Villejuif, France
    Cell Host Microbe 5:107-9. 2009
    In nonmyeloid cells, Shigella hijacks the mitochondrial checkpoint of cell death, thereby inducing a regulated form of necrosis depending on Bnip3 and cyclophilin D. Carneiro et al...
  39. ncbi Changing patterns of antimicrobial susceptibility of Shigella serotypes isolated from children with acute diarrhea in Manipal, South India, a 5 year study
    Ballal Mamatha
    Department of Microbiology, Kasturba Medical College, Karnataka, Manipal, India
    Southeast Asian J Trop Med Public Health 38:863-6. 2007
    This study was carried out to determine the current pattern of Shigella serogroups and their antimicrobial resistance in children with acute gastroenteritis in Manipal, South India...
  40. ncbi Epidemiology of shigellosis in Lagos, Nigeria: trends in antimicrobial resistance
    B A Iwalokun
    Biochemistry Department, College of Medicine, University of Lagos, P M B 12003, Lagos, Nigeria
    J Health Popul Nutr 19:183-90. 2001
    Antimicrobial susceptibility of Shigella spp. and Escherichia coli, isolated from diarrhoeal patients in Lagos, was studied from March 1999 to February 2000. Four hundred fifty-nine isolates were identified as shigellae (62) and E...
  41. pmc Rapid detection of Shigella species in environmental sewage by an immunocapture PCR with universal primers
    Xuanxian Peng
    The Key Laboratory of Education Ministry for Cell Biology and Tumor Cell Engineering, Department of Biology, School of Life Sciences, Xiamen University, Xiamen 361005, People s Republic of China
    Appl Environ Microbiol 68:2580-3. 2002
    In the present study, we developed a quick, highly specific method for detection of Shigella species by combining immunocapturing of the bacteria and a universal primer PCR...
  42. ncbi A comparison of disease caused by Shigella and Campylobacter species: 24 months community based surveillance in 4 slums of Karachi, Pakistan
    Sajid Bashir Soofi
    Department of Paediatrics and Child Health, Aga Khan University, Pakistan
    J Infect Public Health 4:12-21. 2011
    ..We report country specific results for Shigella diarrhea that were derived from a multicenter study conducted in six Asian countries...
  43. ncbi Shigella deploy multiple countermeasures against host innate immune responses
    Hiroshi Ashida
    Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Curr Opin Microbiol 14:16-23. 2011
    ..In this review we highlight current topics concerning Shigella's tactics that interfere with the innate immune systems.
  44. ncbi Frequency and antimicrobial susceptibility of Shigella species isolated in Children Medical Center Hospital, Tehran, Iran, 2001-2006
    Babak Pourakbari
    Pediatrics Infectious Diseases Research Center, Department of Pediatrics Infectious Disease, Tehran University of Medical Sciences, No 62 Gharib Street, Tehran, Iran
    Braz J Infect Dis 14:153-7. 2010
    ..From 15,255 stool samples, 682 (4.5%) were positive for Shigella species. The most common species of Shigella were S. flexneri (48%) and S. sonnei (45%); other results were S...
  45. ncbi Shigella spp. and enteroinvasive Escherichia coli pathogenicity factors
    Claude Parsot
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    FEMS Microbiol Lett 252:11-8. 2005
    Bacteria of Shigella spp. (S. boydii, S. dysenteriae, S. flexneri and S...
  46. ncbi Molecular characterization of multidrug-resistant Shigella species isolated from epidemic and endemic cases of shigellosis in India
    Gururaja Perumal Pazhani
    1National Institute of Cholera and Enteric Diseases, Kolkata, India
    J Med Microbiol 57:856-63. 2008
    b>Shigella species represent one of the growing numbers of antimicrobial-resistant bacteria in developing countries...
  47. ncbi Trends in antimicrobial resistance of fecal Shigella and Salmonella isolates in Tehran, Iran
    Mohammad Taghi Hghi Ashtiani
    Associate Professor of Clinical and Anatomical Pathology, Tehran University of Medical Sciences, Tehran, Iran
    Indian J Pathol Microbiol 52:52-5. 2009
    ..The present study was therefore undertaken to report resistance rates to antimicrobial agents in 2487 stool culture isolates in a tertiary care hospital between 1996 and 2000 and 2001 and 2005...
  48. ncbi Antimicrobial resistance in Shigella species isolated in Dakar, Senegal (2004-2006)
    Jean Marie Sire
    Laboratoire de Biologie Medicale, Institut Pasteur, Dakar, Senegal
    Jpn J Infect Dis 61:307-9. 2008
    ..study was carried out in Dakar, Senegal, to update information about the antimicrobial susceptibility of Shigella spp. isolated from stool specimens...
  49. pmc Regulation of IcsP, the outer membrane protease of the Shigella actin tail assembly protein IcsA, by virulence plasmid regulators VirF and VirB
    Helen J Wing
    Infectious Disease Division, Massachusetts General Hospital, Cambridge, Massachusetts 02139, USA
    J Bacteriol 186:699-705. 2004
    The Shigella outer membrane protease IcsP removes the actin assembly protein IcsA from the bacterial surface, and consequently modulates Shigella actin-based motility and cell-to-cell spread...
  50. ncbi Growing antimicrobial resistance of Shigella isolates
    Shai Ashkenazi
    Department of Paediatrics A, Schneider Children s Medical Center of Israel, 14 Kaplan Street, Petah Tiqva 49202, Israel
    J Antimicrob Chemother 51:427-9. 2003
    Appropriate antibiotic treatment of shigellosis depends on identifying resistance patterns. By studying Shigella isolates in central Israel from 1998 to 2000, and comparing with the period 1991-1992, we identified a significantly ..
  51. ncbi The roles of two-component systems in virulence of pathogenic Escherichia coli and Shigella spp
    Toru Tobe
    Division of Applied Bacteriology, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Adv Exp Med Biol 631:189-99. 2008
    ..coli strains, including pathogenic E. coli and also closely related Shigella spp. Although 25% of the genome of pathogenic E...
  52. pmc A new paradigm of bacteria-gut interplay brought through the study of Shigella
    Chihiro Sasakawa
    Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 86:229-43. 2010
    ..b>Shigella species (abbreviated here as Shigella), the causative agent of bacillary dysentery (shigellosis), are highly ..
  53. pmc Antimicrobial susceptibility and mechanisms of resistance in Shigella and Salmonella isolates from children under five years of age with diarrhea in rural Mozambique
    Inacio Mandomando
    Centro de Investigação em Saúde da Manhiça, Vila da Manhiça, Rua 12, P O Box 1929, Maputo, Mozambique
    Antimicrob Agents Chemother 53:2450-4. 2009
    The antimicrobial susceptibility and mechanisms of resistance of 109 Shigella and 40 Salmonella isolates from children with diarrhea in southern Mozambique were assessed...
  54. ncbi High rate of resistance to locally used antibiotics among enteric bacteria from children in Northern Ghana
    Andrea Djie-Maletz
    Institute of Microbiology and Hygiene, Charite University Medicine Berlin, Berlin, Germany
    J Antimicrob Chemother 61:1315-8. 2008
    ....
  55. pmc Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells
    K Kaniga
    Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York at Stony Brook 11794 5222, USA
    J Bacteriol 177:3965-71. 1995
    ..of the genes encoding two of these secreted proteins, SipB and SipC, indicated that they are homologous to the Shigella sp. invasins IpaB and IpaC, respectively...
  56. ncbi Escherichia coli in disguise: molecular origins of Shigella
    Ruiting Lan
    School of Molecular and Microbial Biosciences, The University of Sydney, NSW 2006, Australia
    Microbes Infect 4:1125-32. 2002
    b>Shigella, which still stands as a genus with four species today, in reality belongs to the extremely diverse species Escherichia coli...
  57. ncbi Shigellosis : challenges & management issues
    Dipika Sur
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    Indian J Med Res 120:454-62. 2004
    ..Shigellosis is caused by Shigella spp. which can be subdivided into four serogroups namely S.sonnei, S.boydii, S.flexneri and S.dysenteriae...
  58. ncbi Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells
    Leticia A M Carneiro
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Cell Host Microbe 5:123-36. 2009
    b>Shigella rapidly kills myeloid cells via a caspase-1 inflammasome-dependent cell death mechanism...
  59. ncbi A role for H-NS in the regulation of the virF gene of Shigella and enteroinvasive Escherichia coli
    G Prosseda
    Dip Biologia Cellulare e dello Sviluppo, Universita La Sapienza, Rome, Italy
    Res Microbiol 149:15-25. 1998
    ..of the bacterial nucleoid, in the expression of the virF gene present on the large virulence plasmid of Shigella and enteroinvasive Escherichia coli in response to different environmental conditions...
  60. ncbi The purified Shigella IpaB and Salmonella SipB translocators share biochemical properties and membrane topology
    Peter J Hume
    University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge, CB2 1QP, UK
    Mol Microbiol 49:425-39. 2003
    An essential early event in Shigella and Salmonella pathogenesis is invasion of non-phagocytic intestinal epithelial cells. Pathogen entry is triggered by the delivery of multiple bacterial effector proteins into target mammalian cells...
  61. pmc Identification and cloning of a novel plasmid-encoded enterotoxin of enteroinvasive Escherichia coli and Shigella strains
    J P Nataro
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, USA
    Infect Immun 63:4721-8. 1995
    ..By DNA hybridization, this gene (designated sen for shigella enterotoxin) was found in 75% of EIEC strains and 83% of Shigella strains and was localized to the inv plasmid of ..
  62. pmc The sudden dominance of blaCTX-M harbouring plasmids in Shigella spp. Circulating in Southern Vietnam
    Nhu Thi Khanh Nguyen
    The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS Negl Trop Dis 4:e702. 2010
    ..Vietnam is representative of a typical transitional middle income country where the spectrum of infectious diseases combined with the spread of drug resistance is shifting and bringing new healthcare challenges...
  63. ncbi Antimicrobial resistance trends of Shigella serotypes in New York City, 2006-2009
    Melissa R Wong
    Bureau of Communicable Disease, New York City Department of Health and Mental Hygiene, New York, New York 10013, USA
    Microb Drug Resist 16:155-61. 2010
    ..Because of increasing antimicrobial resistance to Shigella, empiric treatment options are decreasing...
  64. ncbi Shigella infections in children: new insights
    Shai Ashkenazi
    Department of Pediatrics A, Schneider Children s Medical Center of Israel, 14 Kaplan Street, Petah Tikva 49202, Israel
    Semin Pediatr Infect Dis 15:246-52. 2004
    Shigellosis , the acute enteric infection caused by bacteria of the genus Shigella , has a worldwide distribution with an estimated annual incidence of 164.7 million cases, of which 163.2 million occur in developing countries, and 1...
  65. pmc Emerging resistance to newer antimicrobial agents among Shigella isolated from Finnish foreign travellers
    K Haukka
    Enteric Bacteria Laboratory, Department of Bacterial and Inflammatory Diseases, National Public Health Institute KTL, Helsinki, Finland
    Epidemiol Infect 136:476-82. 2008
    In Finland, most cases of shigellosis are related to travel abroad. Antimicrobial drug resistance of 1814 Shigella strains isolated from Finnish patients during 1990-2005 was studied using discs of 12 antimicrobial agents...
  66. pmc A multicentre study of Shigella diarrhoea in six Asian countries: disease burden, clinical manifestations, and microbiology
    Lorenz von Seidlein
    International Vaccine Institute, Seoul, Korea
    PLoS Med 3:e353. 2006
    ..We conducted a prospective, population-based study in six Asian countries to gain a better understanding of the current disease burden, clinical manifestations, and microbiology of shigellosis in Asia...
  67. ncbi Randomised comparison of ciprofloxacin suspension and pivmecillinam for childhood shigellosis
    M A Salam
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka
    Lancet 352:522-7. 1998
    Infections caused by multiply resistant Shigella species are a major cause of childhood morbidity and mortality in Third World countries...
  68. pmc Synthesis, characterization, and clinical evaluation of conjugate vaccines composed of the O-specific polysaccharides of Shigella dysenteriae type 1, Shigella flexneri type 2a, and Shigella sonnei (Plesiomonas shigelloides) bound to bacterial toxoids
    D N Taylor
    Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Washington, D C 20307 5100
    Infect Immun 61:3678-87. 1993
    ..Y. Chu, and R. Schneerson, Clin. Infect. Dis. 15:346-361, 1992). The O-specific polysaccharides (O-SPs) of Shigella dysenteriae type 1, S. flexneri type 2a, and S. sonnei were covalently bound to carrier proteins...
  69. ncbi Histone-like proteins and the Shigella invasivity regulon
    Gianni Prosseda
    Dip Biologia Cellulare e dello Sviluppo, Universita La Sapienza, Rome, Italy
    Res Microbiol 153:461-8. 2002
    ..In this article we review current knowledge about the regulative role of major histone-like proteins in the silencing/activation of the invasivity phenotype of Shigella, the etiological agent of bacillary dissentery.
  70. pmc Shigella induced reactive arthritis
    J S Hill Gaston
    University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ
    Ann Rheum Dis 64:517-8. 2005
  71. ncbi Shigella and Shiga toxin-producing Escherichia coli causing bloody diarrhea in Latin America
    E L Lopez
    School of Medicine, Universidad de Salvador, Buenos Aires, Argentina
    Infect Dis Clin North Am 14:41-65, viii. 2000
    In Latin America, Shigella and shiga toxin-producing Escherichia coli are the two leading agents in the cause of bloody diarrhea. The already high and increasing antimicrobial resistance of Shigella also is a significant problem...
  72. ncbi Comparison of antimicrobial susceptibility between invasive and non-invasive Shigella organisms
    Yasuko Honma
    Department of Microbiology, School of Medicine, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Int J Antimicrob Agents 21:262-6. 2003
    Antimicrobial susceptibility was determined for ten strains of Shigella spp. comparing invasive (invasion plasmid containing) and non-invasive members of each strain...
  73. ncbi Role of Shigella infection in endometriosis: a novel hypothesis
    V L Kodati
    Vasavi Hospital, 6 1 91 Khairtabad, Hyderabad, AP 500004, India
    Med Hypotheses 70:239-43. 2008
    ..BLAST search results revealed sequence homology to shigella bacterial DNA leading us to hypothesize that infection may be playing a role in the etiology of endometriosis...
  74. pmc Prospective study of systemic and mucosal immune responses in dysenteric patients to specific Shigella invasion plasmid antigens and lipopolysaccharides
    R A Oberhelman
    Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205
    Infect Immun 59:2341-50. 1991
    ..from Peru for the presence of specific antibody to invasion plasmid antigens (Ipa) common to all virulent Shigella strains, by using both a whole-organism enzyme-linked immunosorbent assay (ELISA) and a Western blot (immunoblot) ..
  75. pmc Phylogeny rather than ecology or lifestyle biases the construction of Escherichia coli-Shigella genetic exchange communities
    Elizabeth Skippington
    Institute for Molecular Bioscience and Australian Research Council Centre of Excellence in Bioinformatics, The University of Queensland, Brisbane, Queensland 4072, Australia
    Open Biol 2:120112. 2012
    ..using a graph-based abstraction of inferred genetic-exchange relationships among 27 Escherichia coli and Shigella genomes. We show that although barriers to inter-phylogenetic group lateral transfer are low, E...
  76. pmc MST (molecular serotyping tool): a program for computer-assisted molecular identification of Escherichia coli and Shigella O antigens
    Roney S Coimbra
    Center for Excellence in Bioinformatics, Research Center Rene Rachou, FIOCRUZ MG, Rua Araguari, 741, Room 301, Barro Preto, Belo Horizonte, MG, Brazil CEP 30190 002
    J Clin Microbiol 48:1921-3. 2010
    Escherichia coli and Shigella O antigens can be inferred using the rfb-restriction fragment length polymorphism (RFLP) molecular test...
  77. ncbi Frequency of serovars and antimicrobial resistance in Shigella spp. from Brazil
    Gisele Peirano
    Laboratório de Referência Nacional de Cólera e Outras Enteroinfecções Bacterianas, Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro, RJ, 21045 900, Brasil
    Mem Inst Oswaldo Cruz 101:245-50. 2006
    A total of 296 Shigella spp. were received from State Public Health Laboratories, during the period from 1999 to 2004, by National Reference Laboratory for Cholera and Enteric Diseases (NRLCED)--IOC/Fiocruz, Rio de Janeiro, Brazil...
  78. ncbi Shigella as a foodborne pathogen and current methods for detection in food
    B R Warren
    University of Florida, Department of Food Science and Human Nutrition, 359 FSHN Bldg, Newell Drive, Gainesville, FL 32611, USA
    Crit Rev Food Sci Nutr 46:551-67. 2006
    b>Shigella, the causative agent of shigellosis or "bacillary dysentery," has been increasingly involved in foodborne outbreaks...
  79. ncbi Identification and characterization of simple sequence repeats in the genomes of Shigella species
    Jian Yang
    Laboratory of Bioinformatics, Institute of Biophysics, CAS, Datun Road 15, Chaoyang District, 100101 Beijing, China
    Gene 322:85-92. 2003
    A variety of simple sequence repeats (SSRs) have been identified in the genome of Shigella flexneri serotype 2a (strain Sf301), an enteric pathogen that causes bacillary dysentery in man...
  80. ncbi Shigella infection of intestinal epithelium and circumvention of the host innate defense system
    Hiroshi Ashida
    Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Curr Top Microbiol Immunol 337:231-55. 2009
    b>Shigella, Gram-negative bacteria closely related to Escherichia coli, are highly adapted human pathogens that cause bacillary dysentery...
  81. ncbi The prevalence and antibiotic resistance of Shigella sp. recovered from patients admitted to Bouali Hospital, Tehran, Iran during 1999-2001
    M J Hosseini
    Research Center of Molecular Biology, Baqiyatallah University of Medical Sciences, Tehran, Iran
    Pak J Biol Sci 10:2778-80. 2007
    The present study was conducted to determine the prevalence of serotypes and antibiotic resistance in Shigella spp. isolated from patients admitted to Bouali hospital, Tehran, Iran during 1999 to 2001...
  82. ncbi A five-year antimicrobial resistance pattern of Shigella isolated from stools in the Gondar University hospital, northwest Ethiopia
    Gizachew Yismaw
    Department of Microbiology and Parasitology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
    Trop Doct 38:43-5. 2008
    ..In the last two decades Shigella isolates have become increasingly resistant to many commonly used drugs...
  83. ncbi Systemic shigellosis in South Africa
    Karen H Keddy
    Centre for Enteric Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa
    Clin Infect Dis 54:1448-54. 2012
    ..We examined the clinical and microbiologic characteristics of systemic shigellosis in South Africa, where rates of HIV infection are high...
  84. ncbi Subtype prevalence, plasmid profiles and growing fluoroquinolone resistance in Shigella from Kolkata, India (2001-2007): a hospital-based study
    Suman Nandy
    Bacteriology Division, National Institute of Cholera and Enteric Diseases, Kolkata, India
    Trop Med Int Health 15:1499-507. 2010
    ..We report isolation frequency, plasmid profiles and antimicrobial resistance of Shigella subtypes in Kolkata, India, from a prospective hospital-based study.
  85. ncbi High prevalence of trimethoprim-resistance cassettes in class 1 and 2 integrons in Senegalese Shigella spp isolates
    Amy Gassama Sow
    Unité de Bactériologie Expérimentale, Institut Pasteur, Dakar, Senegal
    J Infect Dev Ctries 4:207-12. 2010
    ..Shigellae are noteworthy for their multiple drug resistance, having gradually acquired resistance to most widely use and inexpensive antimicrobial drugs...
  86. ncbi Prevalence of enterotoxigenic Staphylococcus aureus and Shigella spp. in some raw street vended Indian foods
    Moushumi Ghosh
    Department of Biotechnology and Environmental Sciences, Thapar Institute of Engineering and Technology, Patiala, India
    Int J Environ Health Res 17:151-6. 2007
    ..coriander sauce, of ready-to-eat salads and coconut slices collected were analysed for Staphylococcus aureus and Shigella spp...
  87. ncbi When Shigella tells the cell to hang on
    Guy Tran Van Nhieu
    Inserm U971, Unité de Communications Intercellulaires et Infections Microbiennes, College de France, 11, place Marcelin Berthelot, 75005 Paris Cedex, France
    J Mol Cell Biol 1:64-5. 2009
    OspE, a Shigella type III effector binds to integrin-like kinase and enhances cell adhesion to better disseminate and colonize the intestinal epithelium...
  88. ncbi Neural Wiskott-Aldrich syndrome protein (N-WASP) is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreading
    Toshihiko Suzuki
    PRESTO, Japan Science and Technology Corporation JST, Japan
    Cell Microbiol 4:223-33. 2002
    b>Shigella, the causative agent of bacillary dysentery, is capable of directing its movement within host cells by forming an actin comet tail...
  89. pmc Transposition in Shigella dysenteriae: isolation and analysis of IS911, a new member of the IS3 group of insertion sequences
    M F Prere
    Centre de Biochimie et Génétique Cellulaires du Centre National de la Recherche Scientifique, Toulouse, France
    J Bacteriol 172:4090-9. 1990
    Twenty-nine clear-plaque mutants of bacteriophage lambda were isolated from a Shigella dysenteriae lysogen...
  90. pmc Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery
    Fan Yang
    State Key Laboratory for Molecular Virology and Genetic Engineering, Chinese Ministry of Public Health, Beijing 100052, China
    Nucleic Acids Res 33:6445-58. 2005
    The Shigella bacteria cause bacillary dysentery, which remains a significant threat to public health...
  91. ncbi Distribution of Shigella enterotoxin genes and secreted autotransporter toxin gene among diverse species and serotypes of shigella isolated from Andaman Islands, India
    Subarna Roy
    Regional Medical Research Centre Indian Council of Medical Research, Port Blair, Andaman and Nicobar Islands, India
    Trop Med Int Health 11:1694-8. 2006
    We studied the prevalence and distribution of the newly described genes for Shigella enterotoxins (ShET1 and ShET2, encoded by set and sen genes) and secreted auto-transporter toxin (encoded by sat gene) in clinical isolates from the ..
  92. pmc Automated use of WHONET and SaTScan to detect outbreaks of Shigella spp. using antimicrobial resistance phenotypes
    J Stelling
    Department of Medicine, Brigham and Women s Hospital, WHO Collaborating Centre for Surveillance of Antimicrobial Resistance, Boston, MA 02115, USA
    Epidemiol Infect 138:873-83. 2010
    ..of antimicrobial resistance, we applied the system to the detection of local and regional outbreaks of Shigella spp...
  93. ncbi Live-attenuated Shigella vaccines
    Malabi M Venkatesan
    Division of Bacterial and Rickettsial Diseases, Walter Reed Army Institute of Research, 503 Robert Forney Drive, Room 3s12, Silver Spring, MD 20910, USA
    Expert Rev Vaccines 5:669-86. 2006
    Several live-attenuated Shigella vaccines, with well-defined mutations in specific genes, have shown great promise in eliciting significant immune responses when given orally to volunteers...
  94. ncbi Characteristics of children with Shigella encephalopathy: experience from a large urban diarrhea treatment center in Bangladesh
    Mohammod Jobayer Chisti
    Clinical Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Pediatr Infect Dis J 29:444-7. 2010
    ..Encephalopathy is a serious neurologic complication from shigellosis often with fatal outcome but data on simple clinical and sociodemographic predicting factors are limited. We sought to identify those factors in children...
  95. ncbi Trends in antimicrobial resistance in Shigella species in Karachi, Pakistan
    Erum Khan
    Department of Pathology and Microbiology, Aga Khan University Hospital, Stadium Road, PO Box 3500, Karachi 74800, Sindh, Pakistan
    J Infect Dev Ctries 3:798-802. 2009
    ..The disease is treated with antibiotics. Surveillance of antimicrobial resistance trends is essential owing to the global emergence of antimicrobial resistance...
  96. ncbi Interference of the CadC regulator in the arginine-dependent acid resistance system of Shigella and enteroinvasive E. coli
    Mariassunta Casalino
    Dipartimento di Biologia, Universita Roma Tre, 00146 Rome, Italy
    Int J Med Microbiol 300:289-95. 2010
    A typical pathoadaptive mutation of Shigella and enteroinvasive Escherichia coli (EIEC) is the inactivation of the cad locus which comprises the genes necessary for lysine decarboxylation, an enzyme involved in pH homoeostasis. In E...
  97. ncbi Involvement of the neuropeptide corticotropin-releasing hormone in an animal model of Shigella-related seizures
    Yael Yuhas
    Laboratory of Infectious Diseases, Felsenstein Medical Research Center, Petach Tikva, Israel
    J Neuroimmunol 153:36-9. 2004
    ..We investigated the role of CRH in Shigella-related seizures...
  98. ncbi Isolation of Salmonella and Shigella from fish harvested from the Winam Gulf of Lake Victoria, Kenya
    David Miruka Onyango
    Department of Zoology and School of Public Health and Community, Box 333 40105, Kenya
    J Infect Dev Ctries 3:99-104. 2009
    ..Human infections caused by pathogens transmitted from fish are quite common. The aim of this study was to isolate enteric pathogenic bacteria from fish that might be transmitted to humans after the handling or consumption of such fish...
  99. pmc Detection of Escherichia coli, Salmonella spp., Shigella spp., Yersinia enterocolitica, Vibrio cholerae, and Campylobacter spp. enteropathogens by 3-reaction multiplex polymerase chain reaction
    Oscar G Gomez-Duarte
    Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Iowa Children s Hospital, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 63:1-9. 2009
    ..coli diarrheogenic strains, including Salmonella spp., Shigella spp., Campylobacter spp., Yersinia enterocolitica, and Vibrio cholerae...
  100. ncbi A sensitive seminested PCR method for the detection of Shigella in spiked environmental water samples
    J Theron
    Department of Microbiology and Plant Pathology, University of Pretoria, South Africa
    Water Res 35:869-74. 2001
    A rapid seminested polymerase chain reaction (PCR) method for the specific, sensitive detection of virulent Shigella spp. in spiked environmental water samples was developed...
  101. ncbi Immune responses elicited against multiple enterotoxigenic Escherichia coli fimbriae and mutant LT expressed in attenuated Shigella vaccine strains
    Eileen M Barry
    Center for Vaccine Development, University of Maryland, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Vaccine 21:333-40. 2003
    b>Shigella and enterotoxigenic Escherichia coli (ETEC) continue to be important causes of diarrheal disease in infants and young children in developing countries and are major etiologic agents of traveler's diarrhea...

Research Grants79

  1. Mucosal Immunity, Vaccines and Microbiota Interplay in Humans and Animal
    Marcelo B Sztein; Fiscal Year: 2013
    ..gram negative bacterial human pathogens including Helicobacter pylori, Salmonella enterica serovar Typhi and Shigella, each primarily affecting a distinct major segment of the Gl tract (i.e...
  2. Fatty acid related regulation of enteric infectious disease
    FREDRICK JON KULL; Fiscal Year: 2012
    ..of pathogenic bacteria, including several types of Escherichia coli, Salmonella typhi, Salmonella typhimurium, Shigella flexneri, and Yersinia enterocolitica, contain A/X regulators with homologous positively charged residues and ..
  3. Hospital - Based Surveillance of Acute Febrile Illness in Western Ghat Region of
    ARUNKUMAR GOVINDAKARNAVAR; Fiscal Year: 2013
    ..pneumoniae, H.influenzae, N. meningitidis, Shigella, Campylobacter etc...
  4. Salmonella Vaccines Against Bacterial Enteropathogens
    Roy Curtiss; Fiscal Year: 2013
    ..2 (UNESCO) million are due to infections with enteric pathogens including Salmonella, Escherichia coli and Shigella sp., and other entero-pathogens such as Yersinia sp...
  5. OmpR and SsrB Regulation of Salmonella Virulence
    Linda J Kenney; Fiscal Year: 2013
    ..OmpR has been shown to be required for virulence in Vibrio cholerae, Shigella, Yersinia and other infectious species...
  6. Inhibitors of the Y. pestis cell surface plasminogen activator for biodefense
    Marjorie H Barnes; Fiscal Year: 2010
    ..Furthermore, homologous omptins are virulence factors in E. coli, Salmonella and Shigella, enhancing evasion of the host innate immune system and facilitating inter- and intracellular movement...
  7. Anthrax Toxins Impair Phagocyte Actin-based Motility
    Frederick Southwick; Fiscal Year: 2010
    ..C. Examine the effects of LT on Listeria and Shigella actin-based motility in infected cells, as well as cytoplasmic and reconstituted extracts, using rhodamine actin ..
  8. CT EIP Capacities ACA Grant
    TRACEY L WEEKS; Fiscal Year: 2011
    ..This person will be responsible for testing of specimens for organisms related to FoodNet activities (Salmonella, Shigella, E. coli, Vibrio) as well as the active bacterial core surveillance project (Streptococcus pneumoniae, N...
  9. A. L. lactis-based vaccine for children with broad spectrum for enteric pathogens
    Wendy L Picking; Fiscal Year: 2013
    ..development of a broad-spectrum pediatric vaccine against Category B Biodefense food and water borne pathogens: Shigella, Salmonella and Yersinia enterocolitica...
  10. Molecular mechanisms of pathogen recognition by the Nod-like receptor NLRC4
    Fayyaz S Sutterwala; Fiscal Year: 2012
    ..aeruginosa in vivo. In addition to Pseudomonas, other Gram-negative bacteria such as Salmonella, Legionella and Shigella have also been found to activate the NLRC4 inflammasome...
  11. MOLECULAR GENETIC ANALYSIS OF CHLAMYDIA PATHOGENICITY
    Anthony T Maurelli; Fiscal Year: 2012
    ..Mechanisms of iron acquisition by Chlamydia are completely unknown and our innovative approach will use a Shigella mutant to screen a Chlamydia library. Since the genes for biotin synthesis are absent in C...
  12. Research and Development of a Novel System to Produce Polysaccharide Conjugate Va
    Peng George Wang; Fiscal Year: 2013
    ..The first includes E. coli O157, O104 and Shigella sonnei;the second includes Staphylococcus aureus...
  13. Targeting Bacterial Virulence Transcription Factors, a Novel Antibiotic Approach
    George A Garcia; Fiscal Year: 2011
    ..One example is Shigella flexneri, in which VirF, an AraC-type transcriptional regulator, is responsible for the expression of all ..
  14. The Role of PtdIns-5-P in Cell Function and Signaling
    LUCIA RAMEH-PLANT; Fiscal Year: 2012
    ..upon bacterial invasion of host cells, due to the activity of the bacterial virulence factors IpgD (from Shigella flexneri) and SigD/SopB (from Salmonella enterica), which are phosphatases that use PI-4,5-P2 as substrate...
  15. Multiplexed Detection of Food and Waterborne Pathogens
    Francis Barany; Fiscal Year: 2011
    ..to identify Category B bacterial pathogens (Campylocbacter jejuni, Yersinia enterocolitica, Salmonella spp, Shigella spp, Diarrheagenic E. coli, Pathogenic Vibrio spp, and Listeria monocytogenes)...
  16. Regulation of Pore Formation by Type III Secretion System
    Gloria I Viboud; Fiscal Year: 2010
    ..Some of these organisms include important entropathogens such as Salmonella spp., Shigella spp., Yersinia enterocolitica, Y...
  17. Probing localiztion, interactions, and effector properties of Shigella lpaD
    NICHOLAS EUGENE DICKENSON; Fiscal Year: 2010
    ..of invasion plasmid antigen D (IpaD) in cellular invasion and intercellular spread of the bacterial pathogen Shigella flexneri, the causative agent of bacillary dysentery. S...
  18. Structure-Function of the Shigella dysenteriae heme uptake operon (shu)
    Angela Wilks; Fiscal Year: 2012
    ..b>Shigella spp. and enteroinvasive E...
  19. Understanding transcriptional silencing &anti-silencing mechanisms in Shigella
    Helen J Wing; Fiscal Year: 2013
    ..Here we propose to use the bacterial pathogen Shigella as a model system to study this mechanism of transcriptional regulation...
  20. Campylobacter jejuni outer membrane protein vaccine
    Stuart Thompson; Fiscal Year: 2009
    ..4 million cases of C. jejuni disease in the U.S. annually, with an incidence exceeding that of Salmonella and Shigella combined (5). C...
  21. LISTERIA AND SHIGELLA USE ACTIN TO SPREAD CELL TO CELL
    Frederick Southwick; Fiscal Year: 2013
    ..gram positive bacillus Listeria monocytogenes causes bacteremia and meningitis, while the gram negative bacillus Shigella flexneri causes severe diarrhea and dehydration...
  22. Optimization of novel pyranopyridine efflux pump inhibitors
    Son Truong Nguyen; Fiscal Year: 2013
    ..MBX-2319) that enhances the antibacterial activity of FQ and beta-lactam antibiotics against Escherichia coli, Shigella flexneri, Salmonella enterica, Enterobacter cloacae, and Klebsiella pneumoniae by inhibiting the major efflux ..
  23. RmpA, a unique virulence regulator in emerging Klebsiella pneumoniae
    Valley J Stewart; Fiscal Year: 2012
    ..and extraintestinal infections are caused by specific strains of the closely-related species Escherichia, Shigella, Salmonella and Klebsiella...
  24. MOLECULAR GENETIC ANALYSIS OF CHLAMYDIA PATHOGENICITY
    Anthony T Maurelli; Fiscal Year: 2013
    ..Mechanisms of iron acquisition by Chlamydia are completely unknown and our innovative approach will use a Shigella mutant to screen a Chlamydia library. Since the genes for biotin synthesis are absent in C...
  25. Microbial Invasion of the Intestine at the Cell Extrusion Zone of the Villus Tip
    Manuel R Amieva; Fiscal Year: 2012
    ..Other important pathogens that invade the epithelium include rotavirus, Salmonella, Shigella, Yersinia, enteroinvasive E. coli, and Campylobacter...
  26. Iron transport in Shigella and pathogenic E.coli
    Shelley M Payne; Fiscal Year: 2012
    b>Shigella species and enteroinvasive E. coli invade and multiply within intestinal epithelial cells of their human host...
  27. Bacterial effectors targeting the IKK/NF-kB pathway
    PHILIP ROSS HARDWIDGE; Fiscal Year: 2013
    ..coli (STEC) and related enteric pathogens (e.g. Salmonella, Shigella, Yersinia) are causing increasingly frequent outbreaks of food-borne diarrheal disease, thus constituting ..
  28. A New Point of Use Decontamination Method for Fresh Produce
    ADRIAN J DENVIR; Fiscal Year: 2010
    ..to several microbial species, including Escherichia coli O157:H7, Salmonella species, Listeria monocytogenes, Shigella species, Cyclospora cayetanensis, Hepatitis A virus, and Norwalk-like virus...
  29. Recombinant Attenuated Bacterial Vaccines Against Biodefense Agents
    Roy Curtiss; Fiscal Year: 2013
    ..vectors to deliver additional protective antigens to protect against all pathogenic Yersinia species, all Shigella species and serotypes and most Escherichia coli EPEC and ExPEC pathovars...
  30. Virulence in Enteroaggregative Escherichia coli
    James P Nataro; Fiscal Year: 2013
    ..Aim 4. Role of the Pic protease in EAEC metabolism. Most EAEC strains and nearly all Shigella flexneri 2a strains secrete the Pic protease into the extracellular compartment...
  31. Anti-inflammatory promoting commensal E. coli
    CAMMIE LESSER; Fiscal Year: 2013
    ..of the anti-inflammatory effectors characterized to date are found in enteric pathogens, including Salmonella, Shigella, Yersinia and enteropathogenic E...
  32. Bacterial effectors targeting the IKK/NF-kB pathway
    PHILIP ROSS HARDWIDGE; Fiscal Year: 2012
    ..coli (STEC) and related enteric pathogens (e.g. Salmonella, Shigella, Yersinia) are causing increasingly frequent outbreaks of food borne diarrheal disease, thus constituting ..
  33. Partnership for Detection of Infection by Category B Pathogens
    Frances S Ligler; Fiscal Year: 2011
    ..Target analytes will include, but are not limited to, Brucella, Coxiella, Salmonella, Campylobacter, E. coli, Shigella, Listeria, Cryptosporidium parvum, Giardia lamblia, and VEE...
  34. Blood Transcriptional Biomarker Profiles for Category B Pathogens
    Damien Chaussabel; Fiscal Year: 2013
    ..de Marseille Luminy, France) and diarrheal diseases (Escherichia coli, pathogenic Vibrio strains, Shigella spp, Salmonella, Campylobacter jejuni and Caliciviruses / Department of Molecular Biomedicine, CINVESTAV&..
  35. Disruption of NF-kB signaling by diarrheagenic Escherichia coli
    PHILIP ROSS HARDWIDGE; Fiscal Year: 2010
    ..EHEC and other enteric pathogens (e.g. enteropathogenic E. coli (EPEC), Salmonella, Shigella, Yersinia) utilize a type III secretion system (T3SS) to inject virulence proteins (effectors) into host cells...
  36. Host factors involved in Listeria monocytogenes spread from cell to cell
    HERVE F AGAISSE; Fiscal Year: 2010
    ..Intracellular bacterial pathogens, such as Listeria ssp, Rickettsia spp. and Shigella spp...
  37. Inhibition of T cell Responses by Bacteria
    Michael N Starnbach; Fiscal Year: 2010
    ..initiated studies to characterize the role of CD8+ T cells in immunity to the intracellular bacterial pathogen, Shigella flexneri. During infection, S. flexneri enter cells and escape into the host cell cytosol...
  38. EMERGING INFECTIONS PROGRAM
    Timothy F Jones; Fiscal Year: 2011
    ..cell O157:H7, Salmonella, Shigella, Campylobacter and Listeria over time in a population-based active surveillance program...
  39. Molecular Mechanisms of Modulation of N-WASP activity
    Leigh A Baxt; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Shigella sp. cause 550 million cases of diarrhea or dysentery and 1.1 million deaths annually worldwide. S...
  40. Development of Novel Antimicrobial Peptide Mimics
    Paul B Savage; Fiscal Year: 2011
    ..difficile. RELEVANCE (See instructions): Targeted organisms are Shigella spp. and C. difficile (including drug-resistant forms)...
  41. MOLECULAR GENETICS OF ENTEROPATHOGENIC E. COLI ADHESION
    James B Kaper; Fiscal Year: 2013
    ..S. suggest that the incidence of infections with this pathogen may equal or exceed that of Salmonella, Shigella, Campylobacter, or E. coil O157:H7...
  42. Structural insight into novel mechanisms of type III secretion
    CHARALAMPOS KALODIMOS; Fiscal Year: 2011
    Project Summary A large number of bacterial pathogens, including Shigella, Salmonella, Bordetella, Pseudomonas, and pathogenic E...
  43. Interferon gamma-mediated restriction of Shigella flexneri replication
    Michael N Starnbach; Fiscal Year: 2013
    ..However, very little is known about how IFN? restricts the growth of bacteria, such as Shigella flexneri, that replicate in the host cytoplasm. S...
  44. Structural insight into novel mechanisms of type III secretion
    CHARALAMPOS KALODIMOS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A large number of bacterial pathogens, including Shigella, Salmonella, Bordetella, Pseudomonas, and pathogenic E...
  45. Inhibitors of Type III Secretion and Translocation in yersinia
    Joan Mecsas; Fiscal Year: 2009
    Many gram negative bacterial pathogens, including Yersinia, Salmonella, Pseudomonas, Shigella, enteropathogenic E...
  46. Development of a Laboratory Quality Management System for Food Testing to Meet th
    JACK R MORGAN; Fiscal Year: 2013
    ..capability to isolate and identify bacterial contamination of food by several organisms including Salmonella, Shigella, E. coli O157 and non-O157, and Listeria...
  47. Molecular signaling in Shigella dissemination
    Marcia B Goldberg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Shigella, a major etiologic agent of diarrhea, dysentery, and mortality worldwide, causes disease by invading and disseminating through the colonic mucosa. Shigella sp...
  48. NMR studies of bacterial needle and tip proteins
    Roberto N De Guzman; Fiscal Year: 2012
    ..used NMR to identify the key residues involved in the binding interaction between the needle and tip proteins of Shigella flexneri...
  49. Regulation of intestinal barrier by E. coli curli fibrils
    Cagla Tukel; Fiscal Year: 2013
    ..Alfred Nissle from the feces of a soldier who did not develop diarrhea during a severe Shigella outbreak during World War I...
  50. Role of carbon metabolism in virulence of Shigella flexneri
    Shelley M Payne; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Shigella spp. cause disease by invading and multiplying within human colonic epithelial cells...
  51. MOLECULAR GENETIC ANALYSIS OF SHIGELLA PATHOGENICITY
    Anthony T Maurelli; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Shigella is the causative agent of bacillary dysentery in humans and primates. Over 200 million cases are reported annually and about 650,000 persons die of shigellosis each year...
  52. Mechanisms of intracellular pathogen dissemination
    HERVE F AGAISSE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Listeria monocytogenes and Shigella flexneri are human intestinal pathogens that replicate in the cytosol of infected cells and spread directly from primarily infected cells to neighboring cells...
  53. Development of the www.EcoliCommunity.org Information Resource
    Barry Wanner; Fiscal Year: 2009
    ..coli, Shigella, and Salmonella species, and because many cellular processes are universal...
  54. Probiotics in Pediatric Diarrhea in Peru_Supplement
    Richard A Oberhelman; Fiscal Year: 2012
    ..coli, Shigella, Giardia and Campylobacter...
  55. Antibiotic Resistance and Virulence Gene Transfer in Environmental Pathogens
    Rebekah Potts Nash; Fiscal Year: 2012
    ..Environmental pathogens such as Escherchia coli, Salmonella, and Shigella, which are transmitted to the food chain from polluted irrigation and fertilization systems, have been shown to ..
  56. Manipulation of epithelial cells by Shigella
    CAMMIE LESSER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Shigella, NIAID category B pathogens, cause ~550 million cases of diarrhea or dysentery and 1.1 million deaths each year...
  57. Bacterial avoidance of innate immune detection
    Lovett Evan Reddick; Fiscal Year: 2013
    ..In Aim 2, we propose to define innate immune signaling disruption caused by EspG and its homologue from Shigella, VirA...
  58. Development of New Beta-Lactamase Inhibitors for Resistant Category B Food/Water-
    CHRISTOPHER JOHN BURNS; Fiscal Year: 2012
    ..Their excellent activity against Salmonella (typhi and non-typhi) and Shigella coupled with the fact that they are safe for women and children makes them the sole therapy for complicated ..
  59. Regulation of bacterial pathogen actin-based motility by host cell kinases
    HERVE F AGAISSE; Fiscal Year: 2012
    ..and Shigella spp...
  60. Peptidoglycan metabolism and fragment release
    Joseph P Dillard; Fiscal Year: 2013
    ..In infections caused by Neisseria gonorrhoeae, Bordetella pertussis, or Shigella flexneri, peptidoglycan fragments are thought to induce a large inflammatory response that exacerbates disease or ..
  61. Center for Biomedical Research Excellence in Pathogen-Host Interactions
    Stephen B Pruett; Fiscal Year: 2013
    ..in this COBRE represent a wide range of important human pathogens {Streptococcus pneumoniae, influenza virus, Shigella species, Listeria monocytogenes, and Staphylococcus aureus)...
  62. Bioluminescent reporter phage for the diagnostic detection of shigellosis
    David A Schofield; Fiscal Year: 2013
    ..The disease, caused by Shigella species, is a significant cause of morbidity and mortality accounting for 164 million cases worldwide and 1...
  63. S. typhimiurium Vaccine Against Bacterial Enteropathogens
    Roy Curtiss; Fiscal Year: 2007
    ..the result of infections by Salmonella and other related bacterial enteropathogens including Escherichia coli and Shigella species, and less closely related enteropathogens such as Vibrio cholerae, Campylobacter jejuni and Listeria ..
  64. Intervention strategies of hemorrhagic colitis and HUS
    Edgar Boedeker; Fiscal Year: 2004
    ..produce potent protein toxins named Shiga-like toxins (Stxs) because of their relatedness to Shiga toxin of Shigella dysenteriae...
  65. SHIGA-LIKE TOXIN OF ESCHERICHIA COLI
    ALISON O BRIEN; Fiscal Year: 1991
    ..and SLT-II are antigenically distinct members of a family of cytotoxins that are related to the Shiga toxin of Shigella dysenteriae 1...
  66. Bacterial heme transport and hemoglobin expression
    Douglas Henderson; Fiscal Year: 2009
    ..has indicated that this hypothesis is valid and that heme transport systems from Plesiomonas shigelloides and Shigella dysenteriae are best suited for this work. "One plasmid" systems were created which contain P...
  67. Pathogen-host Interactions that Remodel the Cytoskeleton
    Tina Izard; Fiscal Year: 2010
    The deadly enteropathogen Shigella flexneri usurps components of the actin cytoskeleton for entry and movement in the host cell, and for the formation of protrusions used to infect neighboring cells...
  68. REGULATION BY THE ESCHERICHIA COLI SMALL RNA, DSRA
    DARREN SLEDJESKI; Fiscal Year: 2002
    ..H-NS is an important regulator of virulence factors and other genes in E. coli and related bacteria. In Shigella spp. and enteroinvasive E...
  69. Identification of small molecule furin-like protease inhibitors
    JULIA COPPOLA; Fiscal Year: 2009
    ..Furin-like proteases activate bacterial toxins found in anthrax, shigella, botulinum, pseudomonas, and diphtheria...
  70. THE CLONAL NATURE OF CYTOTOXIGENIC E. COLI
    THOMAS WHITTAM; Fiscal Year: 1992
    ..potent cytotoxins -- called Shiga-like toxins (SLTs) because of their functional similarity to Shiga toxin of Shigella dysenteriae - appears to play an important role in pathogenesis...
  71. THE CLONAL NATURE OF CYTOTOXIGENIC E. COLI
    THOMAS WHITTAM; Fiscal Year: 1991
    ..potent cytotoxins -- called Shiga-like toxins (SLTs) because of their functional similarity to Shiga toxin of Shigella dysenteriae - appears to play an important role in pathogenesis...
  72. B27 BINDING BACTERIAL AND SELF PEPTIDES IN B27 ARTHRITIS
    R Scofield; Fiscal Year: 2000
    ..with the presence of the HLA Class 1 allele B27 and infection with enteric bacteria such as Salmonella, Shigella, Campylobacter, Yersinia, and Klebsiella...
  73. VIRUL FACTORS OF UROPATH ESCHERICHIA COLI
    Peter Redford; Fiscal Year: 2003
    ..is the homology of some PAI sequences to virulence genes recognized in other pathogens such as Salmonella, Shigella, Yersinia, Serratia, Vibrio, Bordetella and Streptococcus...
  74. PATHOGENESIS & INTERVENTION STRATEGIES IN HEMORRHAGIC CO
    Peter Bloom; Fiscal Year: 1999
    ..I. Division at the University of Maryland. With the support of an NRSA, he studied attenuated Shigella vaccine constructs as vectors for foreign antigen delivery in an animal model...
  75. Campylobacter colonization and virulence determinants
    Alain Stintzi; Fiscal Year: 2007
    ..food-borne, are the leading cause of gastroenteritis worldwide, surpassing the number of cases of Salmonella and Shigella combined. Campylobacter spp...
  76. Identification of the ribosomal target of Shiga-like toxins
    NILGUN TUMER; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Infections with Shigella dysenteriae, producing Shiga toxin and Diarrheagenic E. coli, producing Shiga-like toxins (Stx) are responsible for widespread disease and death...
  77. INTERVENTIONAL STRATEGIES FOR HEMORRHAGIC COLITIS
    Edgar Boedeker; Fiscal Year: 2000
    ..potent toxins which are referred to as Shiga-like toxins (SLTs) because of their relatedness to shiga toxin of shigella dysenteriae...
  78. GENETIC AND BIOCHEMICAL ANALYSES OF SHIGA-LIKE TOXINS
    Stephen Calderwood; Fiscal Year: 1993
    ..Shiga toxin from Shigella dysenteriae 1 and Shiga-like toxin (SLT) from Escherichia coli are cytotoxic proteins important in diarrhea and ..
  79. BACTERIAL PATHOGEN GENOME INITIATIVE
    Frederick Blattner; Fiscal Year: 1999
    ..coli genomes we will determine the genomic sequence of Yersinia pestis KIM, causative agent of plague, Shigella flexneri 2 a, the principle agent of dysentary, and Salmonella typhi Ty2, causing Typhoid fever...