serratia marcescens

Summary

Summary: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria found in soil, water, food, and clinical specimens. It is a prominent opportunistic pathogen for hospitalized patients.

Top Publications

  1. ncbi Outbreak of Serratia marcescens in a neonatal intensive care unit: contaminated unmedicated liquid soap and risk factors
    S Buffet-Bataillon
    Unité d Hygiène Hospitalière, Pôle Microorganismes, CHU Pontchaillou, Rennes, France
    J Hosp Infect 72:17-22. 2009
  2. pmc The opportunistic pathogen Serratia marcescens utilizes type VI secretion to target bacterial competitors
    Sarah L Murdoch
    Division of Molecular Microbiology, College of Life Sciences, University of Dundee, United Kingdom
    J Bacteriol 193:6057-69. 2011
  3. ncbi Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila
    Christine Kocks
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cell 123:335-46. 2005
  4. pmc A Serratia marcescens OxyR homolog mediates surface attachment and biofilm formation
    Robert M Q Shanks
    Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, UPMC Eye Center, Pittsburgh, PA 15213, USA
    J Bacteriol 189:7262-72. 2007
  5. pmc Serratia infections: from military experiments to current practice
    Steven D Mahlen
    Department of Pathology and Area Laboratory Services, Madigan Healthcare System, Tacoma, WA 98143, USA
    Clin Microbiol Rev 24:755-91. 2011
  6. pmc Cyclic AMP negatively regulates prodigiosin production by Serratia marcescens
    Eric J Kalivoda
    Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Eye Center, Pittsburgh, PA 15213, USA
    Res Microbiol 161:158-67. 2010
  7. pmc The cyclic AMP-dependent catabolite repression system of Serratia marcescens mediates biofilm formation through regulation of type 1 fimbriae
    Eric J Kalivoda
    Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Appl Environ Microbiol 74:3461-70. 2008
  8. pmc Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital
    Jia Chang Cai
    2nd Affiliated Hospital of Zhejiang University, 88 Jiefang Rd, Hangzhou, China 310009
    Antimicrob Agents Chemother 52:2014-8. 2008
  9. pmc Detection and avoidance of a natural product from the pathogenic bacterium Serratia marcescens by Caenorhabditis elegans
    Elizabeth Pradel
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    Proc Natl Acad Sci U S A 104:2295-300. 2007
  10. ncbi The non-catalytic chitin-binding protein CBP21 from Serratia marcescens is essential for chitin degradation
    Gustav Vaaje-Kolstad
    Department of Chemistry, Biotechnology, and Food Science, Norwegian University of Life Sciences, P O Box 5003, 1432 As, Norway
    J Biol Chem 280:28492-7. 2005

Research Grants

  1. Campylobacter jejuni DNA methylation and gene regulation
    Stuart Thompson; Fiscal Year: 2004
  2. ENZYMOLOGY OF ANTIBIOTIC RESISTANCE
    Richard Armstrong; Fiscal Year: 2009
  3. Novel virulence and exoenzyme regulators
    ROBERT M SHANKS; Fiscal Year: 2013
  4. Toll like receptors in bacterial keratitis
    Eric Pearlman; Fiscal Year: 2012
  5. Characterization of Hemolysin A from Proteus mirabilis
    Todd Weaver; Fiscal Year: 2004
  6. Novel anti-bacterial therapy for gram negative pneumonia
    Kanneganti Murthy; Fiscal Year: 2001
  7. HPMB AS A MODEL FOR HEMOLYSIN SECRETION/ACTIVATION
    TIMOTHY UPHOFF; Fiscal Year: 1999
  8. EVOLUTION AND REGULATION OF MERCURIAL RESISTANCE GENES
    TAPAN MISRA; Fiscal Year: 1992
  9. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    Brian P Lazzaro; Fiscal Year: 2010
  10. Gene expression in commensal tsetse symbionts
    Brian Weiss; Fiscal Year: 2007

Detail Information

Publications266 found, 100 shown here

  1. ncbi Outbreak of Serratia marcescens in a neonatal intensive care unit: contaminated unmedicated liquid soap and risk factors
    S Buffet-Bataillon
    Unité d Hygiène Hospitalière, Pôle Microorganismes, CHU Pontchaillou, Rennes, France
    J Hosp Infect 72:17-22. 2009
    This study describes an outbreak of Serratia marcescens and its investigation and control in a neonatal intensive care unit (NICU). During a three-month period, five infants were colonised or infected by a single strain of S. marcescens...
  2. pmc The opportunistic pathogen Serratia marcescens utilizes type VI secretion to target bacterial competitors
    Sarah L Murdoch
    Division of Molecular Microbiology, College of Life Sciences, University of Dundee, United Kingdom
    J Bacteriol 193:6057-69. 2011
    ..b>Serratia marcescens is an opportunistic enteric pathogen, a class of bacteria responsible for a significant proportion of ..
  3. ncbi Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila
    Christine Kocks
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cell 123:335-46. 2005
    ..Our results suggest that Eater is a major phagocytic receptor for a broad range of bacterial pathogens in Drosophila and provide a powerful model to address the role of phagocytosis in vivo...
  4. pmc A Serratia marcescens OxyR homolog mediates surface attachment and biofilm formation
    Robert M Q Shanks
    Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, UPMC Eye Center, Pittsburgh, PA 15213, USA
    J Bacteriol 189:7262-72. 2007
    ..From a genetic screen for genes that modulate biofilm formation in the opportunistic pathogen Serratia marcescens, mutations in an oxyR homolog and predicted fimbria structural genes were identified. S...
  5. pmc Serratia infections: from military experiments to current practice
    Steven D Mahlen
    Department of Pathology and Area Laboratory Services, Madigan Healthcare System, Tacoma, WA 98143, USA
    Clin Microbiol Rev 24:755-91. 2011
    Serratia species, in particular Serratia marcescens, are significant human pathogens. S. marcescens has a long and interesting taxonomic, medical experimentation, military experimentation, and human clinical infection history...
  6. pmc Cyclic AMP negatively regulates prodigiosin production by Serratia marcescens
    Eric J Kalivoda
    Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Eye Center, Pittsburgh, PA 15213, USA
    Res Microbiol 161:158-67. 2010
    Many Serratia marcescens strains produce the red pigment prodigiosin, which has antimicrobial and anti-tumor properties. Previous reports suggest that cyclic AMP (cAMP) is a positive regulator of prodigiosin production...
  7. pmc The cyclic AMP-dependent catabolite repression system of Serratia marcescens mediates biofilm formation through regulation of type 1 fimbriae
    Eric J Kalivoda
    Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Appl Environ Microbiol 74:3461-70. 2008
    ..This study investigates the roles of glucose and the catabolite repression system in Serratia marcescens biofilm formation...
  8. pmc Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital
    Jia Chang Cai
    2nd Affiliated Hospital of Zhejiang University, 88 Jiefang Rd, Hangzhou, China 310009
    Antimicrob Agents Chemother 52:2014-8. 2008
    Twenty-one Serratia marcescens, ten Klebsiella pneumoniae, and one Escherichia coli isolate with carbapenem resistance or reduced carbapenem susceptibility were recovered from intensive care units (ICUs) in our hospital...
  9. pmc Detection and avoidance of a natural product from the pathogenic bacterium Serratia marcescens by Caenorhabditis elegans
    Elizabeth Pradel
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    Proc Natl Acad Sci U S A 104:2295-300. 2007
    ..Under laboratory conditions, C. elegans will avoid certain pathogens, such as Serratia marcescens, by exiting a bacterial lawn a few hours after entering it...
  10. ncbi The non-catalytic chitin-binding protein CBP21 from Serratia marcescens is essential for chitin degradation
    Gustav Vaaje-Kolstad
    Department of Chemistry, Biotechnology, and Food Science, Norwegian University of Life Sciences, P O Box 5003, 1432 As, Norway
    J Biol Chem 280:28492-7. 2005
    The Gram-negative soil bacterium Serratia marcescens uses three different family 18 chitinases to degrade chitin, an abundant insoluble carbohydrate polymer composed of beta(1,4)-linked units of N-acetylglucosamine...
  11. pmc Biofilm formation and sloughing in Serratia marcescens are controlled by quorum sensing and nutrient cues
    S A Rice
    The Centre for Marine Biofouling and Bio Innovation, The University of New South Wales, Sydney, NSW 2052 Australia
    J Bacteriol 187:3477-85. 2005
    We describe here a role for quorum sensing in the detachment, or sloughing, of Serratia marcescens filamentous biofilms, and we show that nutrient conditions affect the biofilm morphotype. Under reduced carbon or nitrogen conditions, S...
  12. pmc Growth of microorganisms in total parenteral nutrition solutions containing lipid
    Takashi Kuwahara
    Preclinical Assessment Department, Otsuka Pharmaceutical Factory, Inc, Tokushima, Japan
    Int J Med Sci 7:101-9. 2010
    ..nutrition (TPN) solutions, we investigated the growth of the major causes of catheter-related blood stream infection (Staphylococcus aureus, Serratia marcescens, Bacillus cereus, and Candida albicans) in TPN solutions containing lipid.
  13. pmc Catabolite repression control of flagellum production by Serratia marcescens
    Nicholas A Stella
    Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Eye Center, EEI 1020, 203 Lothrop Street, Pittsburgh, PA 15213, USA
    Res Microbiol 159:562-8. 2008
    b>Serratia marcescens is an emerging opportunistic pathogen with a remarkably broad host range. The cAMP-regulated catabolite repression system of S...
  14. pmc Reactive oxygen species-mediated immunity against Leishmania mexicana and Serratia marcescens in the sand phlebotomine fly Lutzomyia longipalpis
    Hector Diaz-Albiter
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom
    J Biol Chem 287:23995-4003. 2012
    ..we show that the concentration of ROS increased in sand fly midguts after they fed on the insect pathogen Serratia marcescens but not after feeding on the Leishmania that uses the sand fly as a vector...
  15. ncbi Smaqnr, a new chromosome-encoded quinolone resistance determinant in Serratia marcescens
    C Velasco
    Department of Microbiology, University of Seville, Seville, Spain
    J Antimicrob Chemother 65:239-42. 2010
    A new pentapeptide repeat (PRP) protein, named SmaQnr, from the clinically relevant species Serratia marcescens, which decreased susceptibility to quinolones when expressed in Escherichia coli, is reported herein.
  16. ncbi Transcriptional downregulator hexS controlling prodigiosin and serrawettin W1 biosynthesis in Serratia marcescens
    Taichiro Tanikawa
    Department of Applied Biological Chemistry, Faculty of Agriculture, Niigata University, Niigata, Japan
    Microbiol Immunol 50:587-96. 2006
    b>Serratia marcescens has been known as a temperature-dependent producer of two chemically different exolipids (red pigment prodigiosin and biosurfactant serrawettin W1) in parallel...
  17. pmc A mobile quorum-sensing system in Serratia marcescens
    Jun Rong Wei
    Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, No 1 Chang Der Street, Taipei 100, Taiwan, Republic of China
    J Bacteriol 188:1518-25. 2006
    ..Here we report that the spnIR quorum-sensing system identified in the enterobacterium Serratia marcescens strain SS-1 is carried in a transposon, TnTIR, which has common characteristics of Tn3 family transposons ..
  18. pmc High temperature and bacteriophages can indirectly select for bacterial pathogenicity in environmental reservoirs
    Ville Petri Friman
    Centre of Excellence in Evolutionary Research, Department of Biological and Environmental Science, University of Jyvaskyla, Jyvaskyla, Finland
    PLoS ONE 6:e17651. 2011
    ..To investigate this, an opportunistic bacterial pathogen, Serratia marcescens, was cultured in the absence and presence of the lytic bacteriophage PPV (Podoviridae) at 25°C and 37°C ..
  19. ncbi Serratia marcescens gene required for surfactant serrawettin W1 production encodes putative aminolipid synthetase belonging to nonribosomal peptide synthetase family
    Hong Li
    Department of Applied Biological Chemistry, Faculty of Agriculture, Niigata University, Niigata, Japan
    Microbiol Immunol 49:303-10. 2005
    Serrawettin W1 produced by Serratia marcescens is a surface active exolipid having various functions supporting behaviors of bacteria on surface environments. Through the genetic analyses of serrawettin-less mutants of S...
  20. ncbi Atomic structure of the Serratia marcescens endonuclease at 1.1 A resolution and the enzyme reaction mechanism
    S V Shlyapnikov
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str 32, Moscow 117984, Russia
    Acta Crystallogr D Biol Crystallogr 56:567-72. 2000
    The three-dimensional crystal structure of Serratia marcescens endonuclease has been refined at 1.1 A resolution to an R factor of 12.9% and an R(free) of 15.6% with the use of anisotropic temperature factors...
  21. ncbi Isolation of Serratia marcescens in the midgut of Rhodnius prolixus: impact on the establishment of the parasite Trypanosoma cruzi in the vector
    P Azambuja
    Departamento de Bioquimica e Biologia Molecular, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Av Brasil 4365, CEP 21045 900, Rio de Janeiro, RJ, Brazil
    Exp Parasitol 107:89-96. 2004
    ..The hemolytic bacteria were isolated and identified as Serratia marcescens biotype A1a (referenced as RPH), which produces the pigment prodigiosin...
  22. pmc SMB-1, a novel subclass B3 metallo-beta-lactamase, associated with ISCR1 and a class 1 integron, from a carbapenem-resistant Serratia marcescens clinical isolate
    Jun ichi Wachino
    Department of Bacteriology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    Antimicrob Agents Chemother 55:5143-9. 2011
    A carbapenem-resistant Serratia marcescens strain, 10mdr148, was identified in a Japanese hospital in 2010...
  23. pmc SmdAB, a heterodimeric ABC-Type multidrug efflux pump, in Serratia marcescens
    Taira Matsuo
    Department of Genome Applied Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Tsushima, Okayama, 700 8530, Japan
    J Bacteriol 190:648-54. 2008
    ..designated smdAB, that encode a multidrug efflux pump from the chromosomal DNA of clinically isolated Serratia marcescens NUSM8906...
  24. pmc Cell density and mobility protect swarming bacteria against antibiotics
    Mitchell T Butler
    University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 107:3776-81. 2010
    ..This work has relevance to the adaptive antibiotic resistance of bacterial biofilms...
  25. ncbi The Serratia marcescens bioH gene encodes an esterase
    Hiroyuki Akatsuka
    Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, Kawagishi 2 chome, Toda, 335 8505, Saitama, Japan
    Gene 302:185-92. 2003
    The 3.9 kb chromosomal DNA was cloned from Serratia marcescens Sr41, which confers on Escherichia coli cells a phenotype of clear halo formation on tributyrin agar plates...
  26. ncbi Inducible antibacterial defense system in C. elegans
    Gustavo V Mallo
    Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Case 906, France
    Curr Biol 12:1209-14. 2002
    ..elegans by the Gram-negative bacterium Serratia marcescens provokes a marked upregulation of the expression of many genes...
  27. ncbi The role of RsmA in the regulation of swarming motility in Serratia marcescens
    S Ang
    School and Graduate Institute of Medical Technology, College of Medicine, National Taiwan University, No. 1, Chan-Der Street, Taipei 100, Taiwan, ROC
    J Biomed Sci 8:160-9. 2001
    ..In Serratia marcescens, a network exists in which the flhDC flagellar regulatory master operon, temperature, nutrient status, and ..
  28. ncbi The LuxR family protein SpnR functions as a negative regulator of N-acylhomoserine lactone-dependent quorum sensing in Serratia marcescens
    Yu Tze Horng
    School and Graduate Institute of Medical Technology, College of Medicine, National Taiwan University, Taipei, ROC
    Mol Microbiol 45:1655-71. 2002
    b>Serratia marcescens SS-1 produces at least four N-acylhomoserine lactones (AHLs) which were identified using high-resolution mass spectrometry and chemical synthesis, as N-(3-oxohexanoyl) homo-serine lactone (3-oxo-C6-HSL), N-hexanoyl- (..
  29. ncbi A generalized transducing phage (phiIF3) for the genomically sequenced Serratia marcescens strain Db11: a tool for functional genomics of an opportunistic human pathogen
    Nicola K Petty
    Department of Biochemistry, University of Cambridge, Building O, Tennis Court Road, Cambridge CB2 1QW, UK
    Microbiology 152:1701-8. 2006
    A bacteriophage (phiIF3) capable of mediating generalized transduction in Serratia marcescens strain Db11 has been isolated and characterized...
  30. pmc Inhibition of quorum sensing in Serratia marcescens AS-1 by synthetic analogs of N-acylhomoserine lactone
    Tomohiro Morohoshi
    Department of Applied Chemistry, Utsunomiya University, 7 1 2 Yoto, Utsunomiya 321 8585, Japan
    Appl Environ Microbiol 73:6339-44. 2007
    ..b>Serratia marcescens is a gram-negative opportunistic pathogen which is responsible for an increasing number of serious ..
  31. ncbi Outbreak of multidrug-resistant Serratia marcescens infection in a neonatal intensive care unit
    Lisa L Maragakis
    Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Infect Control Hosp Epidemiol 29:418-23. 2008
    b>Serratia marcescens causes healthcare-associated infections and significant morbidity and mortality in neonatal intensive care units (NICUs). We report the investigation and control of an outbreak of multidrug-resistant (MDR) S...
  32. pmc SME-type carbapenem-hydrolyzing class A beta-lactamases from geographically diverse Serratia marcescens strains
    A M Queenan
    The R W Johnson Pharmaceutical Research Institute, Raritan, New Jersey 08869, USA
    Antimicrob Agents Chemother 44:3035-9. 2000
    Three sets of carbapenem-resistant Serratia marcescens isolates have been identified in the United States: 1 isolate in Minnesota in 1985 (before approval of carbapenems for clinical use), 5 isolates in Los Angeles (University of ..
  33. pmc The hemolytic and cytolytic activities of Serratia marcescens phospholipase A (PhlA) depend on lysophospholipid production by PhlA
    Ken Shimuta
    Department of Bacteriology I, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    BMC Microbiol 9:261. 2009
    b>Serratia marcescens is a gram-negative bacterium and often causes nosocomial infections. There have been few studies of the virulence factors of this bacterium. The only S...
  34. pmc Serratamolide is a hemolytic factor produced by Serratia marcescens
    Robert M Q Shanks
    Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e36398. 2012
    b>Serratia marcescens is a common contaminant of contact lens cases and lenses. Hemolytic factors of S. marcescens contribute to the virulence of this opportunistic bacterial pathogen...
  35. ncbi AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells: interference with the Akt/NF-kappaB survival pathway
    E Escobar-Díaz
    Departamento de Inmunologia, Centro de Investigaciones Biologicas, CSIC, Madrid, Spain
    Leukemia 19:572-9. 2005
    ..We have studied the effect of the novel cyclodepsipeptide AT514 (serratamolide) from Serratia marcescens on B-CLL cell viability...
  36. pmc RssAB-FlhDC-ShlBA as a major pathogenesis pathway in Serratia marcescens
    Chuan Sheng Lin
    Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Kweishan, Taoyuan, Taiwan, Republic of China
    Infect Immun 78:4870-81. 2010
    b>Serratia marcescens has long been recognized as an important opportunistic pathogen, but the underlying pathogenesis mechanism is not completely clear. Here, we report a key pathogenesis pathway in S...
  37. ncbi Pulsed-resource dynamics constrain the evolution of predator-prey interactions
    Ville Petri Friman
    Centre of Excellence in Evolutionary Research, Department of Biological and Environmental Science, University of Jyvaskyla, Finland
    Am Nat 177:334-45. 2011
    ..how extrinsic resource pulses affect evolutionary and ecological dynamics between the prey bacterium Serratia marcescens and the predatory protozoan Tetrahymena thermophila...
  38. ncbi Inhibitory effects of d-mannose on trypanosomatid lysis induced by Serratia marcescens
    Daniele P Castro
    Departamento de Bioquimica e Biologia Molecular, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Avenida Brasil 4354, Manguinhos, CEP 21045 900, Rio de Janeiro, RJ, Brazil
    Exp Parasitol 115:200-4. 2007
    ..carbohydrates on the lysis of Trypanosoma cruzi, Trypanosoma rangeli and erythocytes caused by the bacteria Serratia marcescens variants SM 365 and RPH. High concentrations of d-mannose were found to protect T. cruzi and T...
  39. pmc Predation on multiple trophic levels shapes the evolution of pathogen virulence
    Ville Petri Friman
    Department of Biological and Environmental Science, Centre of Excellence in Evolutionary Research, University of Jyvaskyla, Jyvaskyla, Finland
    PLoS ONE 4:e6761. 2009
    ..Exposing opportunistic bacterial pathogen Serratia marcescens to predation by protozoan Tetrahymena thermophila decreased its virulence when measured as host moth ..
  40. pmc HasB, the Serratia marcescens TonB paralog, is specific to HasR
    Najla Benevides-Matos
    Unité des Membranes Bactériennes Institut Pasteur CNRS URA 2172, 25 rue du Dr Roux, Paris Cedex 15, France
    J Bacteriol 190:21-7. 2008
    b>Serratia marcescens possesses two functional TonB paralogs, TonB(Sm) and HasB, for energizing TonB-dependent transport receptors (TBDT)...
  41. ncbi Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberis
    Douglas D Bannerman
    Bovine Functional Genomics Laboratory, Beltsville Agricultural Research Center, USDA Agricultural Research Service, Beltsville, MD 20705, USA
    Vet Res 35:681-700. 2004
    Streptococcus uberis and Serratia marcescens are Gram-positive and Gram-negative bacteria, respectively, that induce clinical mastitis...
  42. ncbi Trypanosoma cruzi: ultrastructural studies of adhesion, lysis and biofilm formation by Serratia marcescens
    Daniele P Castro
    Departamento de Bioquimica e Biologia Molecular, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Avenida Brasil 4354, Manguinhos, Rio de Janeiro, CEP 21045 900 RJ, Brazil
    Exp Parasitol 117:201-7. 2007
    ..Incubation of T. cruzi with Serratia marcescens variant SM365, lead to parasite lysis...
  43. pmc The RssAB two-component signal transduction system in Serratia marcescens regulates swarming motility and cell envelope architecture in response to exogenous saturated fatty acids
    Hsin Chih Lai
    Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China
    J Bacteriol 187:3407-14. 2005
    b>Serratia marcescens swarms at 30 degrees C but not at 37 degrees C on a nutrient-rich (LB) agar surface. Mini-Tn5 mutagenesis of S...
  44. ncbi Prevalence and diversity of qnr alleles in AmpC-producing Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii and Serratia marcescens: a multicentre study from Korea
    Yeon Joon Park
    Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Kangnam St Mary s Hospital, 505 Banpo Dong, Seocho Ku, Seoul 137 701, Korea
    J Antimicrob Chemother 60:868-71. 2007
    ..To investigate the prevalence of qnr determinants, their influence on quinolone susceptibility and their association with other plasmid-mediated genes in AmpC-producing Enterobacteriaceae without any selection criteria...
  45. pmc A model of bacterial intestinal infections in Drosophila melanogaster
    Nadine T Nehme
    Equipe Fondation Recherche Médicale, UPR 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire du CNRS, Strasbourg, France
    PLoS Pathog 3:e173. 2007
    b>Serratia marcescens is an entomopathogenic bacterium that opportunistically infects a wide range of hosts, including humans...
  46. pmc Growth of microorganisms in total parenteral nutrition solutions without lipid
    Takashi Kuwahara
    Preclinical Assessment Department, Otsuka Pharmaceutical Factory, Inc, 115 Tateiwa, Naruto, Tokushima 772 8601, Japan
    Int J Med Sci 7:43-7. 2010
    ..nutrition (TPN) solutions, we investigated the growth of the major causes of catheter-related blood stream infection (Staphylococcus aureus, Serratia marcescens, Bacillus cereus, and Candida albicans) in TPN solutions without lipid.
  47. pmc Characterization of the dapA-nlpB genetic locus involved in regulation of swarming motility, cell envelope architecture, hemolysin production, and cell attachment ability in Serratia marcescens
    Po Chi Soo
    Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, No 1 Chan Der Street, Taipei 100, Taiwan, Republic of China
    Infect Immun 73:6075-84. 2005
    Swarming migration of Serratia marcescens requires both flagellar motility and cellular differentiation and is a population-density-dependent behavior...
  48. ncbi Occurrence of extended-spectrum beta-lactamases among chromosomal AmpC-producing Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens in Korea and investigation of screening criteria
    Yeon Joon Park
    Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Kangnam St Mary s Hospital, Seoul 137 040, Korea
    Diagn Microbiol Infect Dis 51:265-9. 2005
    ..beta-lactamases (ESBLs) among AmpC-producing Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens. The 413 isolates (158 E. cloacae, 126 C. freundii, and 129 S...
  49. ncbi Induction of cytokines from polymorphonuclear leukocytes and epithelial cells by ocular isolates of Serratia marcescens
    Emma Hume
    Cooperative Research Centre for Eye Research and Technology, The University of New South Wales, Sydney, Australia
    Ocul Immunol Inflamm 12:287-95. 2004
    ..Inflammatory mediators released by the host may heighten the response. We have examined the ability of human corneal epithelial cells and polymorphonuclear leukocytes (PMNs) to release cytokines upon stimulation with bacteria...
  50. ncbi Molecular characterization of polyphosphate kinase (ppk) gene from Serratia marcescens
    Seung Jin Lee
    Division of Biotechnology, Faculty of Natural Resources and Life Science, Dong A University, Busan 604 714, Korea
    Biotechnol Lett 25:191-7. 2003
    ..phosphate accumulation, a gene encoding polyphosphate kinase (PPK) was cloned from the genomic library of Serratia marcescens by Southern hybridization...
  51. ncbi Removal of biofilm from contact lens storage cases
    Yvonne T Wu
    Brien Holden Vision Institute, School of Optometry and Vision Science, The University of New South Wales, Sydney, New South Wales, Australia
    Invest Ophthalmol Vis Sci 51:6329-33. 2010
    ..This in vitro study aimed to evaluate and compare the efficacy of cleaning practices that are most commonly carried out by lens wearers and recommended by practitioners...
  52. ncbi Stabilization of a chitinase from Serratia marcescens by Gly-->Ala and Xxx-->Pro mutations
    Sigrid Gåseidnes
    Department of Chemistry and Biotechnology, Agricultural University of Norway, PO Box 5040, 1432 As, Norway
    Protein Eng 16:841-6. 2003
    This paper describes attempts to increase the kinetic stability of chitinase B from Serratia marcescens (ChiB) by the introduction of semi-automatically designed rigidifying mutations of the Gly-->Ala and Xxx-->Pro type...
  53. ncbi Isolation and analyses of uranium tolerant Serratia marcescens strains and their utilization for aerobic uranium U(VI) bioadsorption
    Rakshak Kumar
    Microbiology Laboratory, Department of Biotechnology and Bioinformatics, North Eastern Hill University, Umshing, Shillong, Meghalaya 793022, India
    J Microbiol 49:568-74. 2011
    ..1 % U(3)O(8)), indicated a wide occurrence of Serratia marcescens. Five representative S. marcescens isolates were characterized by a polyphasic taxonomic approach...
  54. ncbi Analyses of ampC gene expression in Serratia marcescens reveal new regulatory properties
    Steven D Mahlen
    Center for Research in Anti Infectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Antimicrob Chemother 51:791-802. 2003
    b>Serratia marcescens encodes an inducible, chromosomal beta-lactamase, ampC. Studies addressing the regulation of inducible ampC genes have focused primarily on Enterobacter cloacae and Citrobacter freundii...
  55. ncbi Ventriculoperitoneal shunt infection due to Serratia marcescens
    Andrew A Bremer
    Medical Service, Infectious Disease Section, Veterans Affairs Medical Center, and Center for Prostheses Infection, Baylor College of Medicine, 1333 Moursund Avenue, Suite A221, Houston, TX 77030, USA
    J Infect 50:138-41. 2005
    b>Serratia marcescens is an opportunistic Gram-negative bacillus that is most often associated with infections of the respiratory tract, urinary tract, wounds, and bloodstream...
  56. ncbi Effects of anti-odor automobile air-conditioning system products on adherence of Serratia marcescens to aluminum
    G K Drago
    Department of Biology, Environmental Research Center, Georgia State University, Atlanta 30303, USA
    J Ind Microbiol Biotechnol 29:373-5. 2002
    ..were examined for their potential to inhibit attachment and to detach cells of the Gram-negative bacterium Serratia marcescens on aluminum sections...
  57. pmc SME-3, a novel member of the Serratia marcescens SME family of carbapenem-hydrolyzing beta-lactamases
    Anne Marie Queenan
    Antimicrobial Agents Research Team, Johnson and Johnson Pharmaceutical Research and Development, LLC, Raritan, NJ 08869, USA
    Antimicrob Agents Chemother 50:3485-7. 2006
    Imipenem-resistant Serratia marcescens isolates were cultured from a lung transplant patient given multiple antibiotics over several months. The strains expressed SME-3, a beta-lactamase of the rare SME carbapenem-hydrolyzing family...
  58. ncbi Microbial production of 2,3-butanediol by a mutagenized strain of Serratia marcescens H30
    Liaoyuan Zhang
    State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, PR China
    Bioresour Technol 101:1961-7. 2010
    The production of 2,3-butanediol (2,3-BD) by Serratia marcescens H30 from sucrose was studied. Medium composition for 2,3-BD production by S...
  59. ncbi Efficacy of contact lens multipurpose solutions against serratia marcescens
    Emma B H Hume
    Institute for Eye Research, Sydney, New South Wales, Australia
    Optom Vis Sci 84:316-20. 2007
    To compare the susceptibilities of clinical isolates of Serratia marcescens and the standard ISO ATCC 13880 strain to five contact lens multipurpose disinfection solutions (MPDSs).
  60. ncbi The RssB/RssA two-component system regulates biosynthesis of the tripyrrole antibiotic, prodigiosin, in Serratia marcescens
    Yu Tze Horng
    Department of Laboratory Medicine and Biotechnology, Tzu Chi University, College of Medicine, 701 Section 3, Zhongyang Road, Hualien 97004, Taiwan, ROC
    Int J Med Microbiol 300:304-12. 2010
    b>Serratia marcescens CH-1 produces a red, cell-associated pigment, prodigiosin, synthesized by enzymes encoded in the pig operon...
  61. ncbi What is the best screening method to detect Serratia marcescens colonization during an outbreak in a neonatal intensive care nursery?
    M Giles
    Department of Microbiology and Infectious Diseases, The Royal Women s Hospital, Melbourne, Victoria, Australia
    J Hosp Infect 62:349-52. 2006
    b>Serratia marcescens can cause outbreaks in neonatal intensive care units (NICUs), but the optimum method of screening for carriage has not been determined in this group of patients. During an outbreak of S...
  62. ncbi Identification and characterization of the pswP gene required for the parallel production of prodigiosin and serrawettin W1 in Serratia marcescens
    Shinyu Sunaga
    Department of Applied Biological Chemistry, Faculty of Agriculture, Niigata University, Niigata, Japan
    Microbiol Immunol 48:723-8. 2004
    b>Serratia marcescens mutants defective in production of the red pigment prodigiosin and the biosurfactant serrawettin W1 in parallel were isolated by transposon mutagenesis of strain 274...
  63. ncbi Characterization of HasB, a Serratia marcescens TonB-like protein specifically involved in the haemophore-dependent haem acquisition system
    A Paquelin
    , Institut Pasteur (CNRS URA 2172, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 42:995-1005. 2001
    ..We present evidence that Serratia marcescens, like several other Gram-negative bacteria, has two TonB proteins: the previously characterized TonBSM, and ..
  64. pmc Phenotypic diversification and adaptation of Serratia marcescens MG1 biofilm-derived morphotypes
    Kai Shyang Koh
    The Centre for Marine Biofouling and Bio Innovation, The University of New South Wales, Sydney, NSW 2052, Australia
    J Bacteriol 189:119-30. 2007
    We report here the characterization of dispersal variants from microcolony-type biofilms of Serratia marcescens MG1...
  65. pmc Comparison of four hemolysin-producing organisms (Escherichia coli, Serratia marcescens, Aeromonas hydrophila, and Listeria monocytogenes) for release of inflammatory mediators from various cells
    J Scheffer
    , , Federal Republic of Germany
    J Clin Microbiol 26:544-51. 1988
    We investigated the role of various hemolysin-producing strains (Escherichia coli, Serratia marcescens, Aeromonas hydrophila, and Listeria monocytogenes) in induction of inflammatory mediators, e.g...
  66. ncbi Structure of the imipenem-hydrolyzing class A beta-lactamase SME-1 from Serratia marcescens
    Wladimir Sougakoff
    Laboratoire de Recherche Moléculaire sur les Antibiotiques LRMA, INSERM EMI0004, Faculté de Médecine Pitié Salpêtrière, Universite Pierre et Marie Curie, 75634 Paris Cedex 13, France
    Acta Crystallogr D Biol Crystallogr 58:267-74. 2002
    The structure of the beta-lactamase SME-1 from Serratia marcescens, a class A enzyme characterized by its significant activity against imipenem, has been determined to 2.13 A resolution...
  67. pmc Serratia marcescens quinoprotein glucose dehydrogenase activity mediates medium acidification and inhibition of prodigiosin production by glucose
    James E Fender
    Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Eye Center, Pittsburgh, Pennsylvania, USA
    Appl Environ Microbiol 78:6225-35. 2012
    b>Serratia marcescens is a model organism for the study of secondary metabolites...
  68. ncbi Purification and partial characterization of psychrotrophic Serratia marcescens lipase
    Adham M Abdou
    Department of Food Hygiene, Faculty of Veterinary Medicine, Benha University, Moshtohor 13736 Kaliobyia, Egypt
    J Dairy Sci 86:127-32. 2003
    b>Serratia marcescens isolated from raw milk was found to produce extracellular lipase. The growth of this organism could contribute to flavor defects in milk and dairy products...
  69. ncbi Investigation of an outbreak of Serratia marcescens in a neonatal unit via a case-control study and molecular typing
    N Deborah Friedman
    Department of Infectious Diseases, Southern Health, Monash Medical Centre, Clayton, Melbourne, Victoria, Australia
    Am J Infect Control 36:22-8. 2008
    In March 2004, infection or colonization with Serratia marcescens affected one third of all neonates in a newborn services unit (NBS).
  70. ncbi Clustering of Serratia marcescens infections in a neonatal intensive care unit
    Emmi Sarvikivi
    Hospital for Children and Adolescents, Helsinki, Finland
    Infect Control Hosp Epidemiol 25:723-9. 2004
    To study clusters of infections caused by Serratia marcescens in a neonatal intensive care unit (NICU) and to determine risk factors for S. marcescens infection or colonization.
  71. ncbi Occurrence of an SME-2-producing Serratia marcescens isolate in Canada
    Amélie Carrër
    Int J Antimicrob Agents 31:181-2. 2008
  72. ncbi Cytotoxic activity of Serratia marcescens clinical isolates
    Sylwia Krzyminska
    Department of Microbiology, Faculty of Biology, A Mickiewicz University, Poznan, Poland
    Pol J Microbiol 59:201-5. 2010
    Twenty Serratia marcescens isolates from clinical specimens were examined for their cytotoxic activity on four cell lines (HEp-2, Vero, CHO, J774)...
  73. pmc Mutation of crp mediates Serratia marcescens serralysin and global secreted protein production
    Robert M Q Shanks
    The Charles T Campbell Laboratory, UPMC Eye Center, Ophthalmology and Visual Sciences Research Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15208, USA
    Res Microbiol 164:38-45. 2013
    The bacterial species Serratia marcescens secretes both beneficial and cytotoxic proteins. Here we report that a crp mutant exhibited elevated secreted protease activity...
  74. ncbi A novel quorum sensing system co-regulated by chromosome- and plasmid-encoded genes in Serratia marcescens H30
    Hu Zhu
    Center for Bioengineering and Biotechnology, China University of Petroleum, Qingdao, People s Republic of China
    Mol Cell Biochem 319:87-90. 2008
    The key genes, SpnI and SpnR, involved in AI-1-quorum sensing system of Serratia marcescens strain H30 were cloned and localized using specific primers (5'-CTTGAACTGTTTGACGTCAGC-3' and 5'-AGCGGCCAGGTAATAACTGA-3', 5'-GCCTTCAATGAAAATCAGACC-..
  75. ncbi Serratia marcescens sepsis outbreak in a neonatal intensive care unit
    Ugur Arslan
    Department of Clinical Microbiology, Selcuk University Meram Medical Faculty, Konya, Turkey
    Pediatr Int 52:208-12. 2010
    ..Many organisms have been reported to cause contamination resulting in outbreaks in intensive care units. The aim of the present study was to investigate an outbreak caused by Serratia marcescens in a neonatal intensive care unit (NICU).
  76. ncbi Infectious crystalline keratopathy caused by Serratia marcescens
    Ching Long Chen
    Department of Ophthalmology, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Cornea 26:1011-3. 2007
    ..To report the case of a 70-year-old woman with Serratia infectious crystalline keratopathy...
  77. ncbi Nosocomial outbreak of Serratia marcescens in a neonatal intensive care unit
    Ojan Assadian
    Division of Hospital Hygiene, Clinical Institute for Hygiene and Medical Microbiology, University of Vienna Medical School, Austria
    Infect Control Hosp Epidemiol 23:457-61. 2002
    To investigate and describe an outbreak of Serratia marcescens in a neonatal intensive care unit (NICU) and to report the interventions leading to cessation of the outbreak.
  78. ncbi A method for overcoming DNA degradation during PFGE for Serratia marcescens
    L C O'Reilly
    Division of Microbiology and Infectious Diseases, PathWest Laboratory Medicine WA, Nedlands, WA, Australia
    J Microbiol Methods 85:173-4. 2011
    ..For a particular group of isolates of Serratia marcescens this method was unsuccessful. A combination of techniques was used to overcome the problem.
  79. ncbi Consecutive Serratia marcescens multiclone outbreaks in a neonatal intensive care unit
    Helena C Maltezou
    Department for Interventions in Health Care Facilities, Hellenic Center for Disease Control and Prevention, Athens, Greece
    Am J Infect Control 40:637-42. 2012
    This report describes 3 consecutive outbreaks caused by genetically unrelated Serratia marcescens clones that occurred in a neonatal intensive care unit (NICU) over a 35-month period.
  80. ncbi Ligand delivery by haem carrier proteins: the binding of Serratia marcescens haemophore to its outer membrane receptor is mediated by two distinct peptide regions
    Sylvie Létoffé
    Unité des Membranes Bactériennes, Institut Pasteur CNRS URA2172 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 50:77-88. 2003
    ..The Serratia marcescens haemophore (HasA) is folded into a globular form and tyrosine and histidine are involved in haem ligation...
  81. ncbi Evaluation of the effect of nutrient ratios on biosurfactant production by Serratia marcescens using a Box-Behnken design
    T Roldán-Carrillo
    Instituto Mexicano del Petroleo, Eje Central Lázaro Cárdenas, Norte 152 Col, San Bartolo Atepehuacan, Del Gustavo A Madero, C P 07730, Mexico, Distrito Federal, Mexico
    Colloids Surf B Biointerfaces 86:384-9. 2011
    The strain SmSA, identified as Serratia marcescens and known as a biosurfactant producer, was isolated from hydrocarbon contaminated soil from Veracruz, México...
  82. pmc In vivo acquisition of a plasmid-mediated bla(KPC-2) gene among clonal isolates of Serratia marcescens
    Athanassios Tsakris
    Department of Microbiology, Medical School, University of Athens, Athens, Greece
    J Clin Microbiol 48:2546-9. 2010
    Three patients admitted to a Greek hospital were infected with Serratia marcescens isolates that exhibited reduced susceptibility to carbapenems and harbored Klebsiella pneumoniae carbapenemase (KPC) enzymes...
  83. ncbi Molecular cloning and purification of an endochitinase from Serratia marcescens (Nima)
    Alejandro Ruiz-Sanchez
    Instituto de Ciencias, Agrícolas, Universidad de Guanajuato, Guanajuato, Mexico
    Mol Biotechnol 31:103-11. 2005
    An endochitinase gene from the Serratia marcescens Nima strain (chiA Nima) was cloned, sequenced, and expressed in Escherichia coli DH5alphaF', and the recombinant protein (ChiA Nima) was purified by hydrophobic interaction ..
  84. pmc Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens
    Hideaki Maseda
    Institute of Technology and Science, The University of Tokushima Graduate School, Tokushima, Japan
    Antimicrob Agents Chemother 53:5230-5. 2009
    b>Serratia marcescens is an important opportunistic pathogen in hospitals, where quaternary ammonium compounds are often used for disinfection...
  85. ncbi Nosocomial Serratia marcescens outbreak in Osaka, Japan, from 1999 to 2000
    Hiroshi Takahashi
    Infectious Disease Surveillance Center, National Institute of Infectious Disease, Tokyo, Japan
    Infect Control Hosp Epidemiol 25:156-61. 2004
    To investigate and control an outbreak of bloodstream infections (BSIs) caused by Serratia marcescens and to identify risk factors for respiratory colonization or infection with S. marcescens.
  86. ncbi Using pulsed-field gel electrophoresis in the molecular investigation of an outbreak of Serratia marcescens infection in an intensive care unit
    H Alfizah
    Department of Medical Microbiology and Immunology, Faculty of Medicine, National University of Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia
    Singapore Med J 45:214-8. 2004
    b>Serratia marcescens is a well-known cause of nosocomial infections and outbreaks, particularly in immunocompromised patients with severe underlying disease. An outbreak due to S...
  87. pmc Prevalence of derepressed ampC mutants and extended-spectrum beta-lactamase producers among clinical isolates of Citrobacter freundii, Enterobacter spp., and Serratia marcescens in Korea: dissemination of CTX-M-3, TEM-52, and SHV-12
    Jungmin Kim
    Department of Microbiology, Kyungpook University School of Medicine, Daegu, Korea
    J Clin Microbiol 43:2452-5. 2005
    ..and Serratia marcescens was studied. Of 152 isolates, 45 isolates (29.6%) were derepressed AmpC mutants and 39 isolates (25...
  88. ncbi Optimization of Serratia marcescens lipase production for enantioselective hydrolysis of 3-phenylglycidic acid ester
    Li Gao
    Laboratory of Biocatalysis and Bioprocessing, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China
    J Ind Microbiol Biotechnol 31:525-30. 2004
    Lipase production and cell growth of Serratia marcescens ECU1010 were optimized in shake flasks, with lipase production being enhanced 9.5-fold (4,780 U/l) compared with the initial activity (500 U/l)...
  89. ncbi Three consecutive outbreaks of Serratia marcescens in a neonatal intensive care unit
    Felix Fleisch
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, CH 8091 Zurich, Switzerland
    Clin Infect Dis 34:767-73. 2002
    We investigated an outbreak of Serratia marcescens in the neonatal intensive care unit (NICU) of the University Hospital of Zurich. S...
  90. ncbi Nosocomial neonatal outbreak of Serratia marcescens--analysis of pathogens by pulsed field gel electrophoresis and polymerase chain reaction
    K Steppberger
    Children s Hospital, University of Leipzig, Oststr 21 25, D 04317 Leipzig, Germany
    Infection 30:277-81. 2002
    We investigated an outbreak of Serratia marcescens in the neonatal intensive care unit (NICU) and the pediatric intensive care unit (ICU) of the University Children's Hospital Leipzig, Germany.
  91. ncbi Premature termination of nursing secondary to Serratia marcescens breast pump contamination
    Jonathan Faro
    Department of Obstetrics, Gynecology, Reproductive Sciences, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Obstet Gynecol 117:485-6. 2011
    b>Serratia marcescens, a known pathogen associated with postpartum mastitis, may be identified by its characteristic pigmentation.
  92. ncbi Neutrophilic eccrine hidradenitis secondary to infection with Serratia marcescens
    P Combemale
    Department of Dermatology, Instruction Military Hospital Desgenettes, 108 boulevard Pinel, 69003 Lyon, France
    Br J Dermatol 142:784-8. 2000
    ..Culture of a skin biopsy revealed Serratia marcescens. The dermatosis improved after antibiotic therapy but recurred twice and culture again isolated S...
  93. ncbi Effects of temperature, nutrients, organic matter and coral mucus on the survival of the coral pathogen, Serratia marcescens PDL100
    Erin E Looney
    Department of Environmental Health Science, The University of Georgia, Athens, GA, USA
    Environ Microbiol 12:2479-85. 2010
    b>Serratia marcescens is an enteric bacterium that causes white pox disease in elkhorn coral, Acropora palmata; however, it remains unclear if the pathogenic strain has adapted to seawater or if it requires a host or reservoir for survival...
  94. ncbi Concomitant infections of Anopheles stephensi with Plasmodium berghei and Serratia marcescens: additive detrimental effects
    H M Seitz

    Zentralbl Bakteriol Mikrobiol Hyg A 266:155-66. 1987
    ..In fact we were able to demonstrate that in our A. stephensi colony great numbers of Serratia marcescens could be found in the midgut of the insects. The highest value was 2.3 x 10(7) cfu/ml...
  95. pmc Regulation of swarming motility and flhDC(Sm) expression by RssAB signaling in Serratia marcescens
    Po Chi Soo
    Department of Medical Biotechnology and Laboratory Science, Chang Gung University, 259 Wen Hua First Road, Kweishan, Taoyuan, 333 Taiwan, Republic of China
    J Bacteriol 190:2496-504. 2008
    b>Serratia marcescens cells swarm at 30 degrees C but not at 37 degrees C, and the underlying mechanism is not characterized...
  96. ncbi Tigecycline resistance in Serratia marcescens associated with up-regulation of the SdeXY-HasF efflux system also active against ciprofloxacin and cefpirome
    Michael Hornsey
    Antibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 65:479-82. 2010
    ..by RND-type transporters is known to confer resistance to tigecycline in several Enterobacteriaceae species and we examined the potential of this mechanism in Serratia marcescens using a clinical isolate and laboratory-selected mutants.
  97. pmc Comparative evaluation of an automated repetitive-sequence-based PCR instrument versus pulsed-field gel electrophoresis in the setting of a Serratia marcescens nosocomial infection outbreak
    Marco Ligozzi
    Dipartimento di Patologia, Universita di Verona, and Servizio di Microbiologia, Immunologia e Virologia, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
    J Clin Microbiol 48:1690-5. 2010
    ..was evaluated in comparison with pulsed-field gel electrophoresis (PFGE) to investigate an outbreak of Serratia marcescens infections in a neonatal intensive care unit (NICU)...
  98. ncbi Zymar (Gatifloxacin 0.3%) shows excellent Gram-negative activity against Serratia marcescens and Pseudomonas aeruginosa in a New Zealand White rabbit keratitis model
    Francis S Mah
    Charles T Campbell Ophthalmic Microbiology Laboratory, UPMC Eye Center, Ophthalmology and Visual Sciences Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Cornea 26:585-8. 2007
    ..3%), and fortified tobramycin (14 mg/mL) in the treatment of experimental Gram-negative bacterial infections of Serratia marcescens (SM) and Pseudomonas aeruginosa (PA) in the New Zealand White (NZW) rabbit keratitis model.
  99. ncbi Independent prognostic factors for fatality in patients with urinary tract infection caused by Serratia marcescens
    Jien Wei Liu
    Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung Hsien, Taiwan, Republic of China
    Infect Control Hosp Epidemiol 25:80-2. 2004
    In a retrospective study of 329 cases of nosocomial urinary tract infection caused by Serratia marcescens, 16 (4.9%) were fatal. Female gender (OR, 3.9; CI95, 1.3-11.7; P = .014) and secondary S. marcescens bacteremia (OR, 6.5; CI95, 1...
  100. ncbi Enhanced undecylprodigiosin production from Serratia marcescens SS-1 by medium formulation and amino-acid supplementation
    Yu Hong Wei
    Graduate School of Biotechnology and Bioinformatics, Yuan Ze University, Chung Li, Taoyuan 320, Taiwan
    J Biosci Bioeng 100:466-71. 2005
    b>Serratia marcescens Simon Swift-1 (SS-1) was used to produce a prodigiosin-like pigment, undecylprodigiosin (UP), known to have antitumor activities and potential as an anticancer drug...
  101. pmc Genetic analysis of the chitinase system of Serratia marcescens 2170
    T Watanabe
    Department of Biosystem Science, Graduate School of Science and Technology, Niigata University, Ikarashi, Japan
    J Bacteriol 179:7111-7. 1997
    To carry out a genetic analysis of the degradation and utilization of chitin by Serratia marcescens 2170, various Tn5 insertion mutants with characteristic defects in chitinase production were isolated and partially characterized...

Research Grants17

  1. Campylobacter jejuni DNA methylation and gene regulation
    Stuart Thompson; Fiscal Year: 2004
    ..Specific Aim 3. Elucidate the upstream factors and signals controlling Cj1461 and Cj0355 expression to reveal the entire regulatory circuit. ..
  2. ENZYMOLOGY OF ANTIBIOTIC RESISTANCE
    Richard Armstrong; Fiscal Year: 2009
    ..Plasmid encoded versions of FosA and FosX have been found in multi-drug resistant plasmids Serratia marcescens and P. putida...
  3. Novel virulence and exoenzyme regulators
    ROBERT M SHANKS; Fiscal Year: 2013
    ..Bacterial keratitis is a costly and global problem that results in vision loss and blindness, and Serratia marcescens is a leading agent of community-acquired Gram-negative bacterial keratitis. S...
  4. Toll like receptors in bacterial keratitis
    Eric Pearlman; Fiscal Year: 2012
    ..Proposed experiments will also examine TLR responses to Pseudomonas aeruginosa and Serratia marcescens, which cause bacterial keratitis...
  5. Characterization of Hemolysin A from Proteus mirabilis
    Todd Weaver; Fiscal Year: 2004
    ..for the secretion of large exoproteins, including the Ca2+-independent cytolysins/hemolyins from Serratia marcescens, Edwardsiella tarda, Yersinia pestis and Proteus mirabilis...
  6. Novel anti-bacterial therapy for gram negative pneumonia
    Kanneganti Murthy; Fiscal Year: 2001
    ..strategies that target the N-terminal domain of flagellin reduce mortality in LD9O-100 murine models of Serratia marcescens induced acute pneumonia to less than 10 percent...
  7. HPMB AS A MODEL FOR HEMOLYSIN SECRETION/ACTIVATION
    TIMOTHY UPHOFF; Fiscal Year: 1999
    ..Proteins related to HpmA and B have been identified as virulence factors among other species of Proteus, Serratia marcescens and a variety of other gram-negative bacterial pathogens...
  8. EVOLUTION AND REGULATION OF MERCURIAL RESISTANCE GENES
    TAPAN MISRA; Fiscal Year: 1992
    ..The regulatory genes from the broad spectrum mercurial resistance operons of the Serratia marcescens plasmid pDU1358 and Staphylococcus aureus plasmid pI258 will be cloned into a hyperexpression vector (pI258)..
  9. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    Brian P Lazzaro; Fiscal Year: 2010
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..
  10. Gene expression in commensal tsetse symbionts
    Brian Weiss; Fiscal Year: 2007
    ..These 'paratransgenic' flies and their offspring will then be monitored for changes in fitness, stability of recombinant protein expression and trypanosome vectorial capacity. ..
  11. Campylobacter jejuni proteins induced at 37C
    Stuart Thompson; Fiscal Year: 2007
    ..jejuni proteins that are induced at 37C.Specific Aim 3. Elucidate the roles of specific 37C-induced proteins in human epithelial cell binding and invasion in vitro, and in colonization in a mouse model. ..
  12. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2009
    ..This research is designed to better understand how providers use information from various microbiology laboratory testing methods to choose treatments and to identify strategies that lead to the best patient outcomes. ..
  13. CAMPYLOBACTER FETUS SURFACE LAYER PROTEIN SECRETION
    Stuart Thompson; Fiscal Year: 2002
    ..coli. They will use deletion and mutational analyses to define the C. fetus SapA C-terminal secretion signal. The ability of the SapA secretion to mediate the transport of normally non-secreted proteins also will be assessed. ..
  14. Campylobacter jejuni outer membrane protein vaccine
    Stuart Thompson; Fiscal Year: 2009
    ..Specific Aim 3. We will determine whether immunization of mice with conserved, purified recombinant OMPs protects against subsequent experimental C. jejuni infection. ..
  15. Prevention of Healthcare-Associated Drug-Resistant GNR
    Lisa Maragakis; Fiscal Year: 2006
    ..Maragakis with the skills she needs to develop into an independent clinical investigator in epidemiologic research for the prevention of healthcare-associated infections. ..