Genomes and Genes
Summary: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria found in soil, water, food, and clinical specimens. It is a prominent opportunistic pathogen for hospitalized patients.
Publications266 found, 100 shown here
- Outbreak of Serratia marcescens in a neonatal intensive care unit: contaminated unmedicated liquid soap and risk factorsS Buffet-Bataillon
Unité d Hygiène Hospitalière, Pôle Microorganismes, CHU Pontchaillou, Rennes, France
J Hosp Infect 72:17-22. 2009This study describes an outbreak of Serratia marcescens and its investigation and control in a neonatal intensive care unit (NICU). During a three-month period, five infants were colonised or infected by a single strain of S. marcescens...
- The opportunistic pathogen Serratia marcescens utilizes type VI secretion to target bacterial competitorsSarah L Murdoch
Division of Molecular Microbiology, College of Life Sciences, University of Dundee, United Kingdom
J Bacteriol 193:6057-69. 2011..b>Serratia marcescens is an opportunistic enteric pathogen, a class of bacteria responsible for a significant proportion of ..
- Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in DrosophilaChristine Kocks
Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Cell 123:335-46. 2005..Our results suggest that Eater is a major phagocytic receptor for a broad range of bacterial pathogens in Drosophila and provide a powerful model to address the role of phagocytosis in vivo...
- A Serratia marcescens OxyR homolog mediates surface attachment and biofilm formationRobert M Q Shanks
Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, UPMC Eye Center, Pittsburgh, PA 15213, USA
J Bacteriol 189:7262-72. 2007..From a genetic screen for genes that modulate biofilm formation in the opportunistic pathogen Serratia marcescens, mutations in an oxyR homolog and predicted fimbria structural genes were identified. S...
- Serratia infections: from military experiments to current practiceSteven D Mahlen
Department of Pathology and Area Laboratory Services, Madigan Healthcare System, Tacoma, WA 98143, USA
Clin Microbiol Rev 24:755-91. 2011Serratia species, in particular Serratia marcescens, are significant human pathogens. S. marcescens has a long and interesting taxonomic, medical experimentation, military experimentation, and human clinical infection history...
- Cyclic AMP negatively regulates prodigiosin production by Serratia marcescensEric J Kalivoda
Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Eye Center, Pittsburgh, PA 15213, USA
Res Microbiol 161:158-67. 2010Many Serratia marcescens strains produce the red pigment prodigiosin, which has antimicrobial and anti-tumor properties. Previous reports suggest that cyclic AMP (cAMP) is a positive regulator of prodigiosin production...
- The cyclic AMP-dependent catabolite repression system of Serratia marcescens mediates biofilm formation through regulation of type 1 fimbriaeEric J Kalivoda
Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Appl Environ Microbiol 74:3461-70. 2008..This study investigates the roles of glucose and the catabolite repression system in Serratia marcescens biofilm formation...
- Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospitalJia Chang Cai
2nd Affiliated Hospital of Zhejiang University, 88 Jiefang Rd, Hangzhou, China 310009
Antimicrob Agents Chemother 52:2014-8. 2008Twenty-one Serratia marcescens, ten Klebsiella pneumoniae, and one Escherichia coli isolate with carbapenem resistance or reduced carbapenem susceptibility were recovered from intensive care units (ICUs) in our hospital...
- Detection and avoidance of a natural product from the pathogenic bacterium Serratia marcescens by Caenorhabditis elegansElizabeth Pradel
Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
Proc Natl Acad Sci U S A 104:2295-300. 2007..Under laboratory conditions, C. elegans will avoid certain pathogens, such as Serratia marcescens, by exiting a bacterial lawn a few hours after entering it...
- The non-catalytic chitin-binding protein CBP21 from Serratia marcescens is essential for chitin degradationGustav Vaaje-Kolstad
Department of Chemistry, Biotechnology, and Food Science, Norwegian University of Life Sciences, P O Box 5003, 1432 As, Norway
J Biol Chem 280:28492-7. 2005The Gram-negative soil bacterium Serratia marcescens uses three different family 18 chitinases to degrade chitin, an abundant insoluble carbohydrate polymer composed of beta(1,4)-linked units of N-acetylglucosamine...
- Biofilm formation and sloughing in Serratia marcescens are controlled by quorum sensing and nutrient cuesS A Rice
The Centre for Marine Biofouling and Bio Innovation, The University of New South Wales, Sydney, NSW 2052 Australia
J Bacteriol 187:3477-85. 2005We describe here a role for quorum sensing in the detachment, or sloughing, of Serratia marcescens filamentous biofilms, and we show that nutrient conditions affect the biofilm morphotype. Under reduced carbon or nitrogen conditions, S...
- Growth of microorganisms in total parenteral nutrition solutions containing lipidTakashi Kuwahara
Preclinical Assessment Department, Otsuka Pharmaceutical Factory, Inc, Tokushima, Japan
Int J Med Sci 7:101-9. 2010..nutrition (TPN) solutions, we investigated the growth of the major causes of catheter-related blood stream infection (Staphylococcus aureus, Serratia marcescens, Bacillus cereus, and Candida albicans) in TPN solutions containing lipid.
- Catabolite repression control of flagellum production by Serratia marcescensNicholas A Stella
Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Eye Center, EEI 1020, 203 Lothrop Street, Pittsburgh, PA 15213, USA
Res Microbiol 159:562-8. 2008b>Serratia marcescens is an emerging opportunistic pathogen with a remarkably broad host range. The cAMP-regulated catabolite repression system of S...
- Reactive oxygen species-mediated immunity against Leishmania mexicana and Serratia marcescens in the sand phlebotomine fly Lutzomyia longipalpisHector Diaz-Albiter
Vector Group, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom
J Biol Chem 287:23995-4003. 2012..we show that the concentration of ROS increased in sand fly midguts after they fed on the insect pathogen Serratia marcescens but not after feeding on the Leishmania that uses the sand fly as a vector...
- Smaqnr, a new chromosome-encoded quinolone resistance determinant in Serratia marcescensC Velasco
Department of Microbiology, University of Seville, Seville, Spain
J Antimicrob Chemother 65:239-42. 2010A new pentapeptide repeat (PRP) protein, named SmaQnr, from the clinically relevant species Serratia marcescens, which decreased susceptibility to quinolones when expressed in Escherichia coli, is reported herein.
- Transcriptional downregulator hexS controlling prodigiosin and serrawettin W1 biosynthesis in Serratia marcescensTaichiro Tanikawa
Department of Applied Biological Chemistry, Faculty of Agriculture, Niigata University, Niigata, Japan
Microbiol Immunol 50:587-96. 2006b>Serratia marcescens has been known as a temperature-dependent producer of two chemically different exolipids (red pigment prodigiosin and biosurfactant serrawettin W1) in parallel...
- A mobile quorum-sensing system in Serratia marcescensJun Rong Wei
Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, No 1 Chang Der Street, Taipei 100, Taiwan, Republic of China
J Bacteriol 188:1518-25. 2006..Here we report that the spnIR quorum-sensing system identified in the enterobacterium Serratia marcescens strain SS-1 is carried in a transposon, TnTIR, which has common characteristics of Tn3 family transposons ..
- High temperature and bacteriophages can indirectly select for bacterial pathogenicity in environmental reservoirsVille Petri Friman
Centre of Excellence in Evolutionary Research, Department of Biological and Environmental Science, University of Jyvaskyla, Jyvaskyla, Finland
PLoS ONE 6:e17651. 2011..To investigate this, an opportunistic bacterial pathogen, Serratia marcescens, was cultured in the absence and presence of the lytic bacteriophage PPV (Podoviridae) at 25°C and 37°C ..
- Serratia marcescens gene required for surfactant serrawettin W1 production encodes putative aminolipid synthetase belonging to nonribosomal peptide synthetase familyHong Li
Department of Applied Biological Chemistry, Faculty of Agriculture, Niigata University, Niigata, Japan
Microbiol Immunol 49:303-10. 2005Serrawettin W1 produced by Serratia marcescens is a surface active exolipid having various functions supporting behaviors of bacteria on surface environments. Through the genetic analyses of serrawettin-less mutants of S...
- Atomic structure of the Serratia marcescens endonuclease at 1.1 A resolution and the enzyme reaction mechanismS V Shlyapnikov
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str 32, Moscow 117984, Russia
Acta Crystallogr D Biol Crystallogr 56:567-72. 2000The three-dimensional crystal structure of Serratia marcescens endonuclease has been refined at 1.1 A resolution to an R factor of 12.9% and an R(free) of 15.6% with the use of anisotropic temperature factors...
- Isolation of Serratia marcescens in the midgut of Rhodnius prolixus: impact on the establishment of the parasite Trypanosoma cruzi in the vectorP Azambuja
Departamento de Bioquimica e Biologia Molecular, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Av Brasil 4365, CEP 21045 900, Rio de Janeiro, RJ, Brazil
Exp Parasitol 107:89-96. 2004..The hemolytic bacteria were isolated and identified as Serratia marcescens biotype A1a (referenced as RPH), which produces the pigment prodigiosin...
- SMB-1, a novel subclass B3 metallo-beta-lactamase, associated with ISCR1 and a class 1 integron, from a carbapenem-resistant Serratia marcescens clinical isolateJun ichi Wachino
Department of Bacteriology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
Antimicrob Agents Chemother 55:5143-9. 2011A carbapenem-resistant Serratia marcescens strain, 10mdr148, was identified in a Japanese hospital in 2010...
- SmdAB, a heterodimeric ABC-Type multidrug efflux pump, in Serratia marcescensTaira Matsuo
Department of Genome Applied Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Tsushima, Okayama, 700 8530, Japan
J Bacteriol 190:648-54. 2008..designated smdAB, that encode a multidrug efflux pump from the chromosomal DNA of clinically isolated Serratia marcescens NUSM8906...
- Cell density and mobility protect swarming bacteria against antibioticsMitchell T Butler
University of Texas, Austin, TX 78712, USA
Proc Natl Acad Sci U S A 107:3776-81. 2010..This work has relevance to the adaptive antibiotic resistance of bacterial biofilms...
- The Serratia marcescens bioH gene encodes an esteraseHiroyuki Akatsuka
Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, Kawagishi 2 chome, Toda, 335 8505, Saitama, Japan
Gene 302:185-92. 2003The 3.9 kb chromosomal DNA was cloned from Serratia marcescens Sr41, which confers on Escherichia coli cells a phenotype of clear halo formation on tributyrin agar plates...
- Inducible antibacterial defense system in C. elegansGustavo V Mallo
Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Case 906, France
Curr Biol 12:1209-14. 2002..elegans by the Gram-negative bacterium Serratia marcescens provokes a marked upregulation of the expression of many genes...
- The role of RsmA in the regulation of swarming motility in Serratia marcescensS Ang
School and Graduate Institute of Medical Technology, College of Medicine, National Taiwan University, No. 1, Chan-Der Street, Taipei 100, Taiwan, ROC
J Biomed Sci 8:160-9. 2001..In Serratia marcescens, a network exists in which the flhDC flagellar regulatory master operon, temperature, nutrient status, and ..
- The LuxR family protein SpnR functions as a negative regulator of N-acylhomoserine lactone-dependent quorum sensing in Serratia marcescensYu Tze Horng
School and Graduate Institute of Medical Technology, College of Medicine, National Taiwan University, Taipei, ROC
Mol Microbiol 45:1655-71. 2002b>Serratia marcescens SS-1 produces at least four N-acylhomoserine lactones (AHLs) which were identified using high-resolution mass spectrometry and chemical synthesis, as N-(3-oxohexanoyl) homo-serine lactone (3-oxo-C6-HSL), N-hexanoyl- (..
- A generalized transducing phage (phiIF3) for the genomically sequenced Serratia marcescens strain Db11: a tool for functional genomics of an opportunistic human pathogenNicola K Petty
Department of Biochemistry, University of Cambridge, Building O, Tennis Court Road, Cambridge CB2 1QW, UK
Microbiology 152:1701-8. 2006A bacteriophage (phiIF3) capable of mediating generalized transduction in Serratia marcescens strain Db11 has been isolated and characterized...
- Inhibition of quorum sensing in Serratia marcescens AS-1 by synthetic analogs of N-acylhomoserine lactoneTomohiro Morohoshi
Department of Applied Chemistry, Utsunomiya University, 7 1 2 Yoto, Utsunomiya 321 8585, Japan
Appl Environ Microbiol 73:6339-44. 2007..b>Serratia marcescens is a gram-negative opportunistic pathogen which is responsible for an increasing number of serious ..
- Outbreak of multidrug-resistant Serratia marcescens infection in a neonatal intensive care unitLisa L Maragakis
Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Infect Control Hosp Epidemiol 29:418-23. 2008b>Serratia marcescens causes healthcare-associated infections and significant morbidity and mortality in neonatal intensive care units (NICUs). We report the investigation and control of an outbreak of multidrug-resistant (MDR) S...
- SME-type carbapenem-hydrolyzing class A beta-lactamases from geographically diverse Serratia marcescens strainsA M Queenan
The R W Johnson Pharmaceutical Research Institute, Raritan, New Jersey 08869, USA
Antimicrob Agents Chemother 44:3035-9. 2000Three sets of carbapenem-resistant Serratia marcescens isolates have been identified in the United States: 1 isolate in Minnesota in 1985 (before approval of carbapenems for clinical use), 5 isolates in Los Angeles (University of ..
- The hemolytic and cytolytic activities of Serratia marcescens phospholipase A (PhlA) depend on lysophospholipid production by PhlAKen Shimuta
Department of Bacteriology I, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
BMC Microbiol 9:261. 2009b>Serratia marcescens is a gram-negative bacterium and often causes nosocomial infections. There have been few studies of the virulence factors of this bacterium. The only S...
- Serratamolide is a hemolytic factor produced by Serratia marcescensRobert M Q Shanks
Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 7:e36398. 2012b>Serratia marcescens is a common contaminant of contact lens cases and lenses. Hemolytic factors of S. marcescens contribute to the virulence of this opportunistic bacterial pathogen...
- AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells: interference with the Akt/NF-kappaB survival pathwayE Escobar-Díaz
Departamento de Inmunologia, Centro de Investigaciones Biologicas, CSIC, Madrid, Spain
Leukemia 19:572-9. 2005..We have studied the effect of the novel cyclodepsipeptide AT514 (serratamolide) from Serratia marcescens on B-CLL cell viability...
- RssAB-FlhDC-ShlBA as a major pathogenesis pathway in Serratia marcescensChuan Sheng Lin
Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Kweishan, Taoyuan, Taiwan, Republic of China
Infect Immun 78:4870-81. 2010b>Serratia marcescens has long been recognized as an important opportunistic pathogen, but the underlying pathogenesis mechanism is not completely clear. Here, we report a key pathogenesis pathway in S...
- Pulsed-resource dynamics constrain the evolution of predator-prey interactionsVille Petri Friman
Centre of Excellence in Evolutionary Research, Department of Biological and Environmental Science, University of Jyvaskyla, Finland
Am Nat 177:334-45. 2011..how extrinsic resource pulses affect evolutionary and ecological dynamics between the prey bacterium Serratia marcescens and the predatory protozoan Tetrahymena thermophila...
- Inhibitory effects of d-mannose on trypanosomatid lysis induced by Serratia marcescensDaniele P Castro
Departamento de Bioquimica e Biologia Molecular, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Avenida Brasil 4354, Manguinhos, CEP 21045 900, Rio de Janeiro, RJ, Brazil
Exp Parasitol 115:200-4. 2007..carbohydrates on the lysis of Trypanosoma cruzi, Trypanosoma rangeli and erythocytes caused by the bacteria Serratia marcescens variants SM 365 and RPH. High concentrations of d-mannose were found to protect T. cruzi and T...
- Predation on multiple trophic levels shapes the evolution of pathogen virulenceVille Petri Friman
Department of Biological and Environmental Science, Centre of Excellence in Evolutionary Research, University of Jyvaskyla, Jyvaskyla, Finland
PLoS ONE 4:e6761. 2009..Exposing opportunistic bacterial pathogen Serratia marcescens to predation by protozoan Tetrahymena thermophila decreased its virulence when measured as host moth ..
- HasB, the Serratia marcescens TonB paralog, is specific to HasRNajla Benevides-Matos
Unité des Membranes Bactériennes Institut Pasteur CNRS URA 2172, 25 rue du Dr Roux, Paris Cedex 15, France
J Bacteriol 190:21-7. 2008b>Serratia marcescens possesses two functional TonB paralogs, TonB(Sm) and HasB, for energizing TonB-dependent transport receptors (TBDT)...
- Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberisDouglas D Bannerman
Bovine Functional Genomics Laboratory, Beltsville Agricultural Research Center, USDA Agricultural Research Service, Beltsville, MD 20705, USA
Vet Res 35:681-700. 2004Streptococcus uberis and Serratia marcescens are Gram-positive and Gram-negative bacteria, respectively, that induce clinical mastitis...
- Trypanosoma cruzi: ultrastructural studies of adhesion, lysis and biofilm formation by Serratia marcescensDaniele P Castro
Departamento de Bioquimica e Biologia Molecular, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Avenida Brasil 4354, Manguinhos, Rio de Janeiro, CEP 21045 900 RJ, Brazil
Exp Parasitol 117:201-7. 2007..Incubation of T. cruzi with Serratia marcescens variant SM365, lead to parasite lysis...
- The RssAB two-component signal transduction system in Serratia marcescens regulates swarming motility and cell envelope architecture in response to exogenous saturated fatty acidsHsin Chih Lai
Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China
J Bacteriol 187:3407-14. 2005b>Serratia marcescens swarms at 30 degrees C but not at 37 degrees C on a nutrient-rich (LB) agar surface. Mini-Tn5 mutagenesis of S...
- Prevalence and diversity of qnr alleles in AmpC-producing Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii and Serratia marcescens: a multicentre study from KoreaYeon Joon Park
Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Kangnam St Mary s Hospital, 505 Banpo Dong, Seocho Ku, Seoul 137 701, Korea
J Antimicrob Chemother 60:868-71. 2007..To investigate the prevalence of qnr determinants, their influence on quinolone susceptibility and their association with other plasmid-mediated genes in AmpC-producing Enterobacteriaceae without any selection criteria...
- A model of bacterial intestinal infections in Drosophila melanogasterNadine T Nehme
Equipe Fondation Recherche Médicale, UPR 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire du CNRS, Strasbourg, France
PLoS Pathog 3:e173. 2007b>Serratia marcescens is an entomopathogenic bacterium that opportunistically infects a wide range of hosts, including humans...
- Growth of microorganisms in total parenteral nutrition solutions without lipidTakashi Kuwahara
Preclinical Assessment Department, Otsuka Pharmaceutical Factory, Inc, 115 Tateiwa, Naruto, Tokushima 772 8601, Japan
Int J Med Sci 7:43-7. 2010..nutrition (TPN) solutions, we investigated the growth of the major causes of catheter-related blood stream infection (Staphylococcus aureus, Serratia marcescens, Bacillus cereus, and Candida albicans) in TPN solutions without lipid.
- Characterization of the dapA-nlpB genetic locus involved in regulation of swarming motility, cell envelope architecture, hemolysin production, and cell attachment ability in Serratia marcescensPo Chi Soo
Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, No 1 Chan Der Street, Taipei 100, Taiwan, Republic of China
Infect Immun 73:6075-84. 2005Swarming migration of Serratia marcescens requires both flagellar motility and cellular differentiation and is a population-density-dependent behavior...
- Occurrence of extended-spectrum beta-lactamases among chromosomal AmpC-producing Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens in Korea and investigation of screening criteriaYeon Joon Park
Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Kangnam St Mary s Hospital, Seoul 137 040, Korea
Diagn Microbiol Infect Dis 51:265-9. 2005..beta-lactamases (ESBLs) among AmpC-producing Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens. The 413 isolates (158 E. cloacae, 126 C. freundii, and 129 S...
- Induction of cytokines from polymorphonuclear leukocytes and epithelial cells by ocular isolates of Serratia marcescensEmma Hume
Cooperative Research Centre for Eye Research and Technology, The University of New South Wales, Sydney, Australia
Ocul Immunol Inflamm 12:287-95. 2004..Inflammatory mediators released by the host may heighten the response. We have examined the ability of human corneal epithelial cells and polymorphonuclear leukocytes (PMNs) to release cytokines upon stimulation with bacteria...
- Molecular characterization of polyphosphate kinase (ppk) gene from Serratia marcescensSeung Jin Lee
Division of Biotechnology, Faculty of Natural Resources and Life Science, Dong A University, Busan 604 714, Korea
Biotechnol Lett 25:191-7. 2003..phosphate accumulation, a gene encoding polyphosphate kinase (PPK) was cloned from the genomic library of Serratia marcescens by Southern hybridization...
- Removal of biofilm from contact lens storage casesYvonne T Wu
Brien Holden Vision Institute, School of Optometry and Vision Science, The University of New South Wales, Sydney, New South Wales, Australia
Invest Ophthalmol Vis Sci 51:6329-33. 2010..This in vitro study aimed to evaluate and compare the efficacy of cleaning practices that are most commonly carried out by lens wearers and recommended by practitioners...
- Stabilization of a chitinase from Serratia marcescens by Gly-->Ala and Xxx-->Pro mutationsSigrid Gåseidnes
Department of Chemistry and Biotechnology, Agricultural University of Norway, PO Box 5040, 1432 As, Norway
Protein Eng 16:841-6. 2003This paper describes attempts to increase the kinetic stability of chitinase B from Serratia marcescens (ChiB) by the introduction of semi-automatically designed rigidifying mutations of the Gly-->Ala and Xxx-->Pro type...
- Isolation and analyses of uranium tolerant Serratia marcescens strains and their utilization for aerobic uranium U(VI) bioadsorptionRakshak Kumar
Microbiology Laboratory, Department of Biotechnology and Bioinformatics, North Eastern Hill University, Umshing, Shillong, Meghalaya 793022, India
J Microbiol 49:568-74. 2011..1 % U(3)O(8)), indicated a wide occurrence of Serratia marcescens. Five representative S. marcescens isolates were characterized by a polyphasic taxonomic approach...
- Analyses of ampC gene expression in Serratia marcescens reveal new regulatory propertiesSteven D Mahlen
Center for Research in Anti Infectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
J Antimicrob Chemother 51:791-802. 2003b>Serratia marcescens encodes an inducible, chromosomal beta-lactamase, ampC. Studies addressing the regulation of inducible ampC genes have focused primarily on Enterobacter cloacae and Citrobacter freundii...
- Ventriculoperitoneal shunt infection due to Serratia marcescensAndrew A Bremer
Medical Service, Infectious Disease Section, Veterans Affairs Medical Center, and Center for Prostheses Infection, Baylor College of Medicine, 1333 Moursund Avenue, Suite A221, Houston, TX 77030, USA
J Infect 50:138-41. 2005b>Serratia marcescens is an opportunistic Gram-negative bacillus that is most often associated with infections of the respiratory tract, urinary tract, wounds, and bloodstream...
- Effects of anti-odor automobile air-conditioning system products on adherence of Serratia marcescens to aluminumG K Drago
Department of Biology, Environmental Research Center, Georgia State University, Atlanta 30303, USA
J Ind Microbiol Biotechnol 29:373-5. 2002..were examined for their potential to inhibit attachment and to detach cells of the Gram-negative bacterium Serratia marcescens on aluminum sections...
- SME-3, a novel member of the Serratia marcescens SME family of carbapenem-hydrolyzing beta-lactamasesAnne Marie Queenan
Antimicrobial Agents Research Team, Johnson and Johnson Pharmaceutical Research and Development, LLC, Raritan, NJ 08869, USA
Antimicrob Agents Chemother 50:3485-7. 2006Imipenem-resistant Serratia marcescens isolates were cultured from a lung transplant patient given multiple antibiotics over several months. The strains expressed SME-3, a beta-lactamase of the rare SME carbapenem-hydrolyzing family...
- Microbial production of 2,3-butanediol by a mutagenized strain of Serratia marcescens H30Liaoyuan Zhang
State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, PR China
Bioresour Technol 101:1961-7. 2010The production of 2,3-butanediol (2,3-BD) by Serratia marcescens H30 from sucrose was studied. Medium composition for 2,3-BD production by S...
- Efficacy of contact lens multipurpose solutions against serratia marcescensEmma B H Hume
Institute for Eye Research, Sydney, New South Wales, Australia
Optom Vis Sci 84:316-20. 2007To compare the susceptibilities of clinical isolates of Serratia marcescens and the standard ISO ATCC 13880 strain to five contact lens multipurpose disinfection solutions (MPDSs).
- The RssB/RssA two-component system regulates biosynthesis of the tripyrrole antibiotic, prodigiosin, in Serratia marcescensYu Tze Horng
Department of Laboratory Medicine and Biotechnology, Tzu Chi University, College of Medicine, 701 Section 3, Zhongyang Road, Hualien 97004, Taiwan, ROC
Int J Med Microbiol 300:304-12. 2010b>Serratia marcescens CH-1 produces a red, cell-associated pigment, prodigiosin, synthesized by enzymes encoded in the pig operon...
- What is the best screening method to detect Serratia marcescens colonization during an outbreak in a neonatal intensive care nursery?M Giles
Department of Microbiology and Infectious Diseases, The Royal Women s Hospital, Melbourne, Victoria, Australia
J Hosp Infect 62:349-52. 2006b>Serratia marcescens can cause outbreaks in neonatal intensive care units (NICUs), but the optimum method of screening for carriage has not been determined in this group of patients. During an outbreak of S...
- Identification and characterization of the pswP gene required for the parallel production of prodigiosin and serrawettin W1 in Serratia marcescensShinyu Sunaga
Department of Applied Biological Chemistry, Faculty of Agriculture, Niigata University, Niigata, Japan
Microbiol Immunol 48:723-8. 2004b>Serratia marcescens mutants defective in production of the red pigment prodigiosin and the biosurfactant serrawettin W1 in parallel were isolated by transposon mutagenesis of strain 274...
- Characterization of HasB, a Serratia marcescens TonB-like protein specifically involved in the haemophore-dependent haem acquisition systemA Paquelin
, Institut Pasteur (CNRS URA 2172, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Mol Microbiol 42:995-1005. 2001..We present evidence that Serratia marcescens, like several other Gram-negative bacteria, has two TonB proteins: the previously characterized TonBSM, and ..
- Phenotypic diversification and adaptation of Serratia marcescens MG1 biofilm-derived morphotypesKai Shyang Koh
The Centre for Marine Biofouling and Bio Innovation, The University of New South Wales, Sydney, NSW 2052, Australia
J Bacteriol 189:119-30. 2007We report here the characterization of dispersal variants from microcolony-type biofilms of Serratia marcescens MG1...
- Comparison of four hemolysin-producing organisms (Escherichia coli, Serratia marcescens, Aeromonas hydrophila, and Listeria monocytogenes) for release of inflammatory mediators from various cellsJ Scheffer
, , Federal Republic of Germany
J Clin Microbiol 26:544-51. 1988We investigated the role of various hemolysin-producing strains (Escherichia coli, Serratia marcescens, Aeromonas hydrophila, and Listeria monocytogenes) in induction of inflammatory mediators, e.g...
- Structure of the imipenem-hydrolyzing class A beta-lactamase SME-1 from Serratia marcescensWladimir Sougakoff
Laboratoire de Recherche Moléculaire sur les Antibiotiques LRMA, INSERM EMI0004, Faculté de Médecine Pitié Salpêtrière, Universite Pierre et Marie Curie, 75634 Paris Cedex 13, France
Acta Crystallogr D Biol Crystallogr 58:267-74. 2002The structure of the beta-lactamase SME-1 from Serratia marcescens, a class A enzyme characterized by its significant activity against imipenem, has been determined to 2.13 A resolution...
- Serratia marcescens quinoprotein glucose dehydrogenase activity mediates medium acidification and inhibition of prodigiosin production by glucoseJames E Fender
Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Eye Center, Pittsburgh, Pennsylvania, USA
Appl Environ Microbiol 78:6225-35. 2012b>Serratia marcescens is a model organism for the study of secondary metabolites...
- Purification and partial characterization of psychrotrophic Serratia marcescens lipaseAdham M Abdou
Department of Food Hygiene, Faculty of Veterinary Medicine, Benha University, Moshtohor 13736 Kaliobyia, Egypt
J Dairy Sci 86:127-32. 2003b>Serratia marcescens isolated from raw milk was found to produce extracellular lipase. The growth of this organism could contribute to flavor defects in milk and dairy products...
- Investigation of an outbreak of Serratia marcescens in a neonatal unit via a case-control study and molecular typingN Deborah Friedman
Department of Infectious Diseases, Southern Health, Monash Medical Centre, Clayton, Melbourne, Victoria, Australia
Am J Infect Control 36:22-8. 2008In March 2004, infection or colonization with Serratia marcescens affected one third of all neonates in a newborn services unit (NBS).
- Clustering of Serratia marcescens infections in a neonatal intensive care unitEmmi Sarvikivi
Hospital for Children and Adolescents, Helsinki, Finland
Infect Control Hosp Epidemiol 25:723-9. 2004To study clusters of infections caused by Serratia marcescens in a neonatal intensive care unit (NICU) and to determine risk factors for S. marcescens infection or colonization.
- Occurrence of an SME-2-producing Serratia marcescens isolate in CanadaAmélie Carrër
Int J Antimicrob Agents 31:181-2. 2008
- Cytotoxic activity of Serratia marcescens clinical isolatesSylwia Krzyminska
Department of Microbiology, Faculty of Biology, A Mickiewicz University, Poznan, Poland
Pol J Microbiol 59:201-5. 2010Twenty Serratia marcescens isolates from clinical specimens were examined for their cytotoxic activity on four cell lines (HEp-2, Vero, CHO, J774)...
- Mutation of crp mediates Serratia marcescens serralysin and global secreted protein productionRobert M Q Shanks
The Charles T Campbell Laboratory, UPMC Eye Center, Ophthalmology and Visual Sciences Research Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15208, USA
Res Microbiol 164:38-45. 2013The bacterial species Serratia marcescens secretes both beneficial and cytotoxic proteins. Here we report that a crp mutant exhibited elevated secreted protease activity...
- A novel quorum sensing system co-regulated by chromosome- and plasmid-encoded genes in Serratia marcescens H30Hu Zhu
Center for Bioengineering and Biotechnology, China University of Petroleum, Qingdao, People s Republic of China
Mol Cell Biochem 319:87-90. 2008The key genes, SpnI and SpnR, involved in AI-1-quorum sensing system of Serratia marcescens strain H30 were cloned and localized using specific primers (5'-CTTGAACTGTTTGACGTCAGC-3' and 5'-AGCGGCCAGGTAATAACTGA-3', 5'-GCCTTCAATGAAAATCAGACC-..
- Serratia marcescens sepsis outbreak in a neonatal intensive care unitUgur Arslan
Department of Clinical Microbiology, Selcuk University Meram Medical Faculty, Konya, Turkey
Pediatr Int 52:208-12. 2010..Many organisms have been reported to cause contamination resulting in outbreaks in intensive care units. The aim of the present study was to investigate an outbreak caused by Serratia marcescens in a neonatal intensive care unit (NICU).
- Infectious crystalline keratopathy caused by Serratia marcescensChing Long Chen
Department of Ophthalmology, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
Cornea 26:1011-3. 2007..To report the case of a 70-year-old woman with Serratia infectious crystalline keratopathy...
- Nosocomial outbreak of Serratia marcescens in a neonatal intensive care unitOjan Assadian
Division of Hospital Hygiene, Clinical Institute for Hygiene and Medical Microbiology, University of Vienna Medical School, Austria
Infect Control Hosp Epidemiol 23:457-61. 2002To investigate and describe an outbreak of Serratia marcescens in a neonatal intensive care unit (NICU) and to report the interventions leading to cessation of the outbreak.
- A method for overcoming DNA degradation during PFGE for Serratia marcescensL C O'Reilly
Division of Microbiology and Infectious Diseases, PathWest Laboratory Medicine WA, Nedlands, WA, Australia
J Microbiol Methods 85:173-4. 2011..For a particular group of isolates of Serratia marcescens this method was unsuccessful. A combination of techniques was used to overcome the problem.
- Consecutive Serratia marcescens multiclone outbreaks in a neonatal intensive care unitHelena C Maltezou
Department for Interventions in Health Care Facilities, Hellenic Center for Disease Control and Prevention, Athens, Greece
Am J Infect Control 40:637-42. 2012This report describes 3 consecutive outbreaks caused by genetically unrelated Serratia marcescens clones that occurred in a neonatal intensive care unit (NICU) over a 35-month period.
- Ligand delivery by haem carrier proteins: the binding of Serratia marcescens haemophore to its outer membrane receptor is mediated by two distinct peptide regionsSylvie Létoffé
Unité des Membranes Bactériennes, Institut Pasteur CNRS URA2172 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Mol Microbiol 50:77-88. 2003..The Serratia marcescens haemophore (HasA) is folded into a globular form and tyrosine and histidine are involved in haem ligation...
- Evaluation of the effect of nutrient ratios on biosurfactant production by Serratia marcescens using a Box-Behnken designT Roldán-Carrillo
Instituto Mexicano del Petroleo, Eje Central Lázaro Cárdenas, Norte 152 Col, San Bartolo Atepehuacan, Del Gustavo A Madero, C P 07730, Mexico, Distrito Federal, Mexico
Colloids Surf B Biointerfaces 86:384-9. 2011The strain SmSA, identified as Serratia marcescens and known as a biosurfactant producer, was isolated from hydrocarbon contaminated soil from Veracruz, México...
- In vivo acquisition of a plasmid-mediated bla(KPC-2) gene among clonal isolates of Serratia marcescensAthanassios Tsakris
Department of Microbiology, Medical School, University of Athens, Athens, Greece
J Clin Microbiol 48:2546-9. 2010Three patients admitted to a Greek hospital were infected with Serratia marcescens isolates that exhibited reduced susceptibility to carbapenems and harbored Klebsiella pneumoniae carbapenemase (KPC) enzymes...
- Molecular cloning and purification of an endochitinase from Serratia marcescens (Nima)Alejandro Ruiz-Sanchez
Instituto de Ciencias, Agrícolas, Universidad de Guanajuato, Guanajuato, Mexico
Mol Biotechnol 31:103-11. 2005An endochitinase gene from the Serratia marcescens Nima strain (chiA Nima) was cloned, sequenced, and expressed in Escherichia coli DH5alphaF', and the recombinant protein (ChiA Nima) was purified by hydrophobic interaction ..
- Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescensHideaki Maseda
Institute of Technology and Science, The University of Tokushima Graduate School, Tokushima, Japan
Antimicrob Agents Chemother 53:5230-5. 2009b>Serratia marcescens is an important opportunistic pathogen in hospitals, where quaternary ammonium compounds are often used for disinfection...
- Nosocomial Serratia marcescens outbreak in Osaka, Japan, from 1999 to 2000Hiroshi Takahashi
Infectious Disease Surveillance Center, National Institute of Infectious Disease, Tokyo, Japan
Infect Control Hosp Epidemiol 25:156-61. 2004To investigate and control an outbreak of bloodstream infections (BSIs) caused by Serratia marcescens and to identify risk factors for respiratory colonization or infection with S. marcescens.
- Using pulsed-field gel electrophoresis in the molecular investigation of an outbreak of Serratia marcescens infection in an intensive care unitH Alfizah
Department of Medical Microbiology and Immunology, Faculty of Medicine, National University of Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia
Singapore Med J 45:214-8. 2004b>Serratia marcescens is a well-known cause of nosocomial infections and outbreaks, particularly in immunocompromised patients with severe underlying disease. An outbreak due to S...
- Prevalence of derepressed ampC mutants and extended-spectrum beta-lactamase producers among clinical isolates of Citrobacter freundii, Enterobacter spp., and Serratia marcescens in Korea: dissemination of CTX-M-3, TEM-52, and SHV-12Jungmin Kim
Department of Microbiology, Kyungpook University School of Medicine, Daegu, Korea
J Clin Microbiol 43:2452-5. 2005..and Serratia marcescens was studied. Of 152 isolates, 45 isolates (29.6%) were derepressed AmpC mutants and 39 isolates (25...
- Optimization of Serratia marcescens lipase production for enantioselective hydrolysis of 3-phenylglycidic acid esterLi Gao
Laboratory of Biocatalysis and Bioprocessing, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China
J Ind Microbiol Biotechnol 31:525-30. 2004Lipase production and cell growth of Serratia marcescens ECU1010 were optimized in shake flasks, with lipase production being enhanced 9.5-fold (4,780 U/l) compared with the initial activity (500 U/l)...
- Three consecutive outbreaks of Serratia marcescens in a neonatal intensive care unitFelix Fleisch
Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, CH 8091 Zurich, Switzerland
Clin Infect Dis 34:767-73. 2002We investigated an outbreak of Serratia marcescens in the neonatal intensive care unit (NICU) of the University Hospital of Zurich. S...
- Nosocomial neonatal outbreak of Serratia marcescens--analysis of pathogens by pulsed field gel electrophoresis and polymerase chain reactionK Steppberger
Children s Hospital, University of Leipzig, Oststr 21 25, D 04317 Leipzig, Germany
Infection 30:277-81. 2002We investigated an outbreak of Serratia marcescens in the neonatal intensive care unit (NICU) and the pediatric intensive care unit (ICU) of the University Children's Hospital Leipzig, Germany.
- Premature termination of nursing secondary to Serratia marcescens breast pump contaminationJonathan Faro
Department of Obstetrics, Gynecology, Reproductive Sciences, University of Texas Health Science Center at Houston, Houston, Texas, USA
Obstet Gynecol 117:485-6. 2011b>Serratia marcescens, a known pathogen associated with postpartum mastitis, may be identified by its characteristic pigmentation.
- Neutrophilic eccrine hidradenitis secondary to infection with Serratia marcescensP Combemale
Department of Dermatology, Instruction Military Hospital Desgenettes, 108 boulevard Pinel, 69003 Lyon, France
Br J Dermatol 142:784-8. 2000..Culture of a skin biopsy revealed Serratia marcescens. The dermatosis improved after antibiotic therapy but recurred twice and culture again isolated S...
- Effects of temperature, nutrients, organic matter and coral mucus on the survival of the coral pathogen, Serratia marcescens PDL100Erin E Looney
Department of Environmental Health Science, The University of Georgia, Athens, GA, USA
Environ Microbiol 12:2479-85. 2010b>Serratia marcescens is an enteric bacterium that causes white pox disease in elkhorn coral, Acropora palmata; however, it remains unclear if the pathogenic strain has adapted to seawater or if it requires a host or reservoir for survival...
- Concomitant infections of Anopheles stephensi with Plasmodium berghei and Serratia marcescens: additive detrimental effectsH M Seitz
Zentralbl Bakteriol Mikrobiol Hyg A 266:155-66. 1987..In fact we were able to demonstrate that in our A. stephensi colony great numbers of Serratia marcescens could be found in the midgut of the insects. The highest value was 2.3 x 10(7) cfu/ml...
- Regulation of swarming motility and flhDC(Sm) expression by RssAB signaling in Serratia marcescensPo Chi Soo
Department of Medical Biotechnology and Laboratory Science, Chang Gung University, 259 Wen Hua First Road, Kweishan, Taoyuan, 333 Taiwan, Republic of China
J Bacteriol 190:2496-504. 2008b>Serratia marcescens cells swarm at 30 degrees C but not at 37 degrees C, and the underlying mechanism is not characterized...
- Tigecycline resistance in Serratia marcescens associated with up-regulation of the SdeXY-HasF efflux system also active against ciprofloxacin and cefpiromeMichael Hornsey
Antibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK
J Antimicrob Chemother 65:479-82. 2010..by RND-type transporters is known to confer resistance to tigecycline in several Enterobacteriaceae species and we examined the potential of this mechanism in Serratia marcescens using a clinical isolate and laboratory-selected mutants.
- Comparative evaluation of an automated repetitive-sequence-based PCR instrument versus pulsed-field gel electrophoresis in the setting of a Serratia marcescens nosocomial infection outbreakMarco Ligozzi
Dipartimento di Patologia, Universita di Verona, and Servizio di Microbiologia, Immunologia e Virologia, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
J Clin Microbiol 48:1690-5. 2010..was evaluated in comparison with pulsed-field gel electrophoresis (PFGE) to investigate an outbreak of Serratia marcescens infections in a neonatal intensive care unit (NICU)...
- Zymar (Gatifloxacin 0.3%) shows excellent Gram-negative activity against Serratia marcescens and Pseudomonas aeruginosa in a New Zealand White rabbit keratitis modelFrancis S Mah
Charles T Campbell Ophthalmic Microbiology Laboratory, UPMC Eye Center, Ophthalmology and Visual Sciences Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Cornea 26:585-8. 2007..3%), and fortified tobramycin (14 mg/mL) in the treatment of experimental Gram-negative bacterial infections of Serratia marcescens (SM) and Pseudomonas aeruginosa (PA) in the New Zealand White (NZW) rabbit keratitis model.
- Independent prognostic factors for fatality in patients with urinary tract infection caused by Serratia marcescensJien Wei Liu
Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung Hsien, Taiwan, Republic of China
Infect Control Hosp Epidemiol 25:80-2. 2004In a retrospective study of 329 cases of nosocomial urinary tract infection caused by Serratia marcescens, 16 (4.9%) were fatal. Female gender (OR, 3.9; CI95, 1.3-11.7; P = .014) and secondary S. marcescens bacteremia (OR, 6.5; CI95, 1...
- Enhanced undecylprodigiosin production from Serratia marcescens SS-1 by medium formulation and amino-acid supplementationYu Hong Wei
Graduate School of Biotechnology and Bioinformatics, Yuan Ze University, Chung Li, Taoyuan 320, Taiwan
J Biosci Bioeng 100:466-71. 2005b>Serratia marcescens Simon Swift-1 (SS-1) was used to produce a prodigiosin-like pigment, undecylprodigiosin (UP), known to have antitumor activities and potential as an anticancer drug...
- Genetic analysis of the chitinase system of Serratia marcescens 2170T Watanabe
Department of Biosystem Science, Graduate School of Science and Technology, Niigata University, Ikarashi, Japan
J Bacteriol 179:7111-7. 1997To carry out a genetic analysis of the degradation and utilization of chitin by Serratia marcescens 2170, various Tn5 insertion mutants with characteristic defects in chitinase production were isolated and partially characterized...
- Campylobacter jejuni DNA methylation and gene regulationStuart Thompson; Fiscal Year: 2004..Specific Aim 3. Elucidate the upstream factors and signals controlling Cj1461 and Cj0355 expression to reveal the entire regulatory circuit. ..
- ENZYMOLOGY OF ANTIBIOTIC RESISTANCERichard Armstrong; Fiscal Year: 2009..Plasmid encoded versions of FosA and FosX have been found in multi-drug resistant plasmids Serratia marcescens and P. putida...
- Novel virulence and exoenzyme regulatorsROBERT M SHANKS; Fiscal Year: 2013..Bacterial keratitis is a costly and global problem that results in vision loss and blindness, and Serratia marcescens is a leading agent of community-acquired Gram-negative bacterial keratitis. S...
- Toll like receptors in bacterial keratitisEric Pearlman; Fiscal Year: 2012..Proposed experiments will also examine TLR responses to Pseudomonas aeruginosa and Serratia marcescens, which cause bacterial keratitis...
- Characterization of Hemolysin A from Proteus mirabilisTodd Weaver; Fiscal Year: 2004..for the secretion of large exoproteins, including the Ca2+-independent cytolysins/hemolyins from Serratia marcescens, Edwardsiella tarda, Yersinia pestis and Proteus mirabilis...
- Novel anti-bacterial therapy for gram negative pneumoniaKanneganti Murthy; Fiscal Year: 2001..strategies that target the N-terminal domain of flagellin reduce mortality in LD9O-100 murine models of Serratia marcescens induced acute pneumonia to less than 10 percent...
- HPMB AS A MODEL FOR HEMOLYSIN SECRETION/ACTIVATIONTIMOTHY UPHOFF; Fiscal Year: 1999..Proteins related to HpmA and B have been identified as virulence factors among other species of Proteus, Serratia marcescens and a variety of other gram-negative bacterial pathogens...
- EVOLUTION AND REGULATION OF MERCURIAL RESISTANCE GENESTAPAN MISRA; Fiscal Year: 1992..The regulatory genes from the broad spectrum mercurial resistance operons of the Serratia marcescens plasmid pDU1358 and Staphylococcus aureus plasmid pI258 will be cloned into a hyperexpression vector (pI258)..
- Evolutionary Genomics of Anti-Malaria Genes in MosquitoBrian P Lazzaro; Fiscal Year: 2010..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..
- Gene expression in commensal tsetse symbiontsBrian Weiss; Fiscal Year: 2007..These 'paratransgenic' flies and their offspring will then be monitored for changes in fitness, stability of recombinant protein expression and trypanosome vectorial capacity. ..
- Campylobacter jejuni proteins induced at 37CStuart Thompson; Fiscal Year: 2007..jejuni proteins that are induced at 37C.Specific Aim 3. Elucidate the roles of specific 37C-induced proteins in human epithelial cell binding and invasion in vitro, and in colonization in a mouse model. ..
- Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB InfectionsLisa Maragakis; Fiscal Year: 2009..This research is designed to better understand how providers use information from various microbiology laboratory testing methods to choose treatments and to identify strategies that lead to the best patient outcomes. ..
- CAMPYLOBACTER FETUS SURFACE LAYER PROTEIN SECRETIONStuart Thompson; Fiscal Year: 2002..coli. They will use deletion and mutational analyses to define the C. fetus SapA C-terminal secretion signal. The ability of the SapA secretion to mediate the transport of normally non-secreted proteins also will be assessed. ..
- Campylobacter jejuni outer membrane protein vaccineStuart Thompson; Fiscal Year: 2009..Specific Aim 3. We will determine whether immunization of mice with conserved, purified recombinant OMPs protects against subsequent experimental C. jejuni infection. ..
- Prevention of Healthcare-Associated Drug-Resistant GNRLisa Maragakis; Fiscal Year: 2006..Maragakis with the skills she needs to develop into an independent clinical investigator in epidemiologic research for the prevention of healthcare-associated infections. ..