salmonella typhi

Summary

Summary: A serotype of SALMONELLA ENTERICA which is the etiologic agent of TYPHOID FEVER.

Top Publications

  1. pmc Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants
    Gemma C Langridge
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
    Genome Res 19:2308-16. 2009
  2. pmc A strand-specific RNA-Seq analysis of the transcriptome of the typhoid bacillus Salmonella typhi
    Timothy T Perkins
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    PLoS Genet 5:e1000569. 2009
  3. pmc A study of typhoid fever in five Asian countries: disease burden and implications for controls
    R Leon Ochiai
    International Vaccine Institute, Seoul, Republic of Korea
    Bull World Health Organ 86:260-8. 2008
  4. pmc High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi
    Kathryn E Holt
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nat Genet 40:987-93. 2008
  5. pmc Invasive salmonellosis among children admitted to a rural Tanzanian hospital and a comparison with previous studies
    George Mtove
    National Institute for Medical Research Amani Centre, Tanga, Tanzania
    PLoS ONE 5:e9244. 2010
  6. ncbi Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18
    J Parkhill
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Nature 413:848-52. 2001
  7. pmc Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi
    Kathryn E Holt
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    BMC Genomics 10:36. 2009
  8. ncbi Antimicrobial resistance in typhoidal salmonellae
    B N Harish
    Department of Microbiology, Institute of National Importance, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India
    Indian J Med Microbiol 29:223-9. 2011
  9. pmc Typhoid fever and invasive nontyphoid salmonellosis, Malawi and South Africa
    Nicholas A Feasey
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi
    Emerg Infect Dis 16:1448-51. 2010
  10. pmc A mouse model for the human pathogen Salmonella typhi
    Jeongmin Song
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Host Microbe 8:369-76. 2010

Detail Information

Publications360 found, 100 shown here

  1. pmc Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants
    Gemma C Langridge
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
    Genome Res 19:2308-16. 2009
    ..Typhi in the gall bladder. This screen validated our hypothesis that we can simultaneously assay every gene in the genome to identify niche-specific essential genes...
  2. pmc A strand-specific RNA-Seq analysis of the transcriptome of the typhoid bacillus Salmonella typhi
    Timothy T Perkins
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    PLoS Genet 5:e1000569. 2009
    ..Typhi OmpR regulon and identify novel OmpR regulated transcripts. Thus, ssRNA-seq provides a novel and powerful approach to the characterization of the bacterial transcriptome...
  3. pmc A study of typhoid fever in five Asian countries: disease burden and implications for controls
    R Leon Ochiai
    International Vaccine Institute, Seoul, Republic of Korea
    Bull World Health Organ 86:260-8. 2008
    ..To inform policy-makers about introduction of preventive interventions against typhoid, including vaccination...
  4. pmc High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi
    Kathryn E Holt
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nat Genet 40:987-93. 2008
    ..The observed patterns of genetic isolation and drift are consistent with the proposed key role of asymptomatic carriers of Typhi as the main reservoir of this pathogen, highlighting the need for identification and treatment of carriers...
  5. pmc Invasive salmonellosis among children admitted to a rural Tanzanian hospital and a comparison with previous studies
    George Mtove
    National Institute for Medical Research Amani Centre, Tanga, Tanzania
    PLoS ONE 5:e9244. 2010
    ..We compared our main findings with those from previous studies among children in sub-Saharan Africa...
  6. ncbi Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18
    J Parkhill
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Nature 413:848-52. 2001
    ..typhi. CT18 harbours a 218,150-bp multiple-drug-resistance incH1 plasmid (pHCM1), and a 106,516-bp cryptic plasmid (pHCM2), which shows recent common ancestry with a virulence plasmid of Yersinia pestis...
  7. pmc Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi
    Kathryn E Holt
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    BMC Genomics 10:36. 2009
    ..The accumulation of pseudogenes is a key feature of these and other host-adapted pathogens, and overlapping pseudogene complements are evident in Paratyphi A and Typhi...
  8. ncbi Antimicrobial resistance in typhoidal salmonellae
    B N Harish
    Department of Microbiology, Institute of National Importance, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India
    Indian J Med Microbiol 29:223-9. 2011
    ..This review is based on published research from our centre and literature from elsewhere in the world. This brief review tries to summarize the history and recent trends in antimicrobial resistance in typhoidal salmonellae...
  9. pmc Typhoid fever and invasive nontyphoid salmonellosis, Malawi and South Africa
    Nicholas A Feasey
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi
    Emerg Infect Dis 16:1448-51. 2010
    ..Invasive nontyphoid salmonellosis showed a clear bimodal age distribution; the infection developed in women at a younger age than in men. Case frequency for typhoid fever was lower than for salmonellosis...
  10. pmc A mouse model for the human pathogen Salmonella typhi
    Jeongmin Song
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Host Microbe 8:369-76. 2010
    ..We expect that this mouse model will be a useful resource for understanding S. Typhi pathogenesis and for evaluating potential vaccine candidates against typhoid fever...
  11. ncbi Antimicrobial resistance in typhoidal and nontyphoidal salmonellae
    Christopher M Parry
    Division of Medical Microbiology and Genitourinary Medicine and The National Centre for Zoonosis Research, Faculty of Medicine, University of Liverpool, Liverpool, UK
    Curr Opin Infect Dis 21:531-8. 2008
    ..Recent studies documenting the occurrence and types of resistance, with particular reference to quinolones and extended spectrum cephalosporins, and new approaches to treatment are reviewed...
  12. pmc Typhoid in Kenya is associated with a dominant multidrug-resistant Salmonella enterica serovar Typhi haplotype that is also widespread in Southeast Asia
    Samuel Kariuki
    Centre for Microbiology Research, Kenya Medical Research Institute, P O Box 43640 00100, Nairobi, Kenya
    J Clin Microbiol 48:2171-6. 2010
    ..Given the emergence of this aggressive MDR haplotype, careful selection and monitoring of antibiotic usage will be required in Kenya, and potentially other regions of sub-Saharan Africa...
  13. pmc Salmonella enterica serovar Typhi possesses a unique repertoire of fimbrial gene sequences
    S M Townsend
    Department of Medical Microbiology and Immunology, College of Medicine, Texas A and M University, College Station, Texas 77843, USA
    Infect Immun 69:2894-901. 2001
    ..However, the serotype Typhi genome differed from that of all other Salmonella serotypes investigated in that it contained a unique combination of putative fimbrial operons...
  14. pmc Emergence of a globally dominant IncHI1 plasmid type associated with multiple drug resistant typhoid
    Kathryn E Holt
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS Negl Trop Dis 5:e1245. 2011
    ..Typhi host. The PST6 plasmid conferred the ability to grow in high salt medium (4.7% NaCl), which we demonstrate is due to the presence in PST6 of the Tn6062 transposon encoding BetU...
  15. pmc Live oral typhoid vaccine Ty21a induces cross-reactive humoral immune responses against Salmonella enterica serovar Paratyphi A and S. Paratyphi B in humans
    Rezwanul Wahid
    Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Vaccine Immunol 19:825-34. 2012
    ..Whereas cross-reactive humoral immune responses to S. Paratyphi A or B antigens are demonstrable following Ty21a immunization, they cannot explain the efficacy data gleaned from controlled field trials...
  16. pmc A mouse model of Salmonella typhi infection
    Ramkumar Mathur
    Department of Microbiology and Immunology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Cell 151:590-602. 2012
    ..Typhi. Therefore, tlr11(-/-) mice represent a small-animal model for the study of the immune response to S. Typhi and for the development of vaccines against this important human pathogen...
  17. pmc Characterization of anti-Salmonella enterica serotype Typhi antibody responses in bacteremic Bangladeshi patients by an immunoaffinity proteomics-based technology
    Richelle C Charles
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Clin Vaccine Immunol 17:1188-95. 2010
    ..Typhi-infected patients and detected anti-HlyE responses at the time of clinical presentation in patients but not in controls. These findings could assist in the development of improved diagnostic assays...
  18. pmc Evaluation in volunteers of a candidate live oral attenuated Salmonella typhi vector vaccine
    D M Hone
    Department of Medicine, University of Maryland, Baltimore 21201
    J Clin Invest 90:412-20. 1992
    Candidate vector vaccine strain CVD 906 (aroC- and aroD- derivative of virulent Salmonella typhi strain ISP1820) was evaluated in phase 1 clinical trials. The first nine volunteers ingested a single dose of 5 x 10(7) CVD 906 bacilli...
  19. pmc Chronic and acute infection of the gall bladder by Salmonella Typhi: understanding the carrier state
    Geoffrey Gonzalez-Escobedo
    Center for Microbial Interface Biology and the Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    Nat Rev Microbiol 9:9-14. 2011
    ..In this Progress article, we explore recent advances in our understanding of the mechanisms by which Salmonella spp.--predominantly S. Typhi--colonize and persist in the human gall bladder...
  20. pmc Bacteremic typhoid fever in children in an urban slum, Bangladesh
    W Abdullah Brooks
    ICDDR, B Centre for Health and Population Research, Mohakhali, Dhaka 1000, Bangladesh
    Emerg Infect Dis 11:326-9. 2005
    ..The relative risk for preschool children compared with older persons was 8.9. Our regression model showed that these children were clinically ill, which suggests a role for preschool immunization...
  21. ncbi So similar, yet so different: uncovering distinctive features in the genomes of Salmonella enterica serovars Typhimurium and Typhi
    Sébastien C Sabbagh
    Department of Microbiology and Immunology, University of Montreal, Montreal, QC, Canada
    FEMS Microbiol Lett 305:1-13. 2010
    ..This comparative genomic overview highlights hypotheses for future investigations on S. enterica pathogenesis and the basis of host specificity...
  22. pmc Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection
    Stephen J Libby
    Departments of Laboratory Medicine and Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:15589-94. 2010
    ..Typhi in mice. The hu-SRC-SCID mouse provides an unprecedented opportunity to gain insights into S. Typhi pathogenesis and devise strategies for the prevention of typhoid fever...
  23. ncbi The efficacy of a Salmonella typhi Vi conjugate vaccine in two-to-five-year-old children
    F Y Lin
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
    N Engl J Med 344:1263-9. 2001
    ..A newly devised conjugate of the capsular polysaccharide of Salmonella typhi, Vi, bound to nontoxic recombinant Pseudomonas aeruginosa exotoxin A (rEPA), has enhanced immunogenicity in ..
  24. ncbi Typhoid fever
    Christopher M Parry
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    N Engl J Med 347:1770-82. 2002
  25. pmc The sensitivity of real-time PCR amplification targeting invasive Salmonella serovars in biological specimens
    Tran Vu Thieu Nga
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    BMC Infect Dis 10:125. 2010
    ..Invasive Salmonella serovars, which cause enteric fever, can be commonly cultured from the blood of infected patients. Yet, the isolation of invasive Salmonella serovars from blood is protracted and potentially insensitive...
  26. pmc Experimental identification and characterization of 97 novel npcRNA candidates in Salmonella enterica serovar Typhi
    Suresh V Chinni
    Institute of Experimental Pathology ZMBE, University of Muenster, Von Esmarch Str 56, 48149 Muenster, Germany
    Nucleic Acids Res 38:5893-908. 2010
    ..typhi Hfq protein, supporting an important role of Hfq in npcRNA networks. This study points to novel functional npcRNA candidates potentially involved in various regulatory roles including the pathogenicity of S. typhi...
  27. pmc Clinical response and outcome of infection with Salmonella enterica serotype Typhi with decreased susceptibility to fluoroquinolones: a United States foodnet multicenter retrospective cohort study
    John A Crump
    Enteric Diseases Epidemiology Branch, National Center for Zoonotic, Vectorborne, and Enteric Diseases, MS A 38, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 52:1278-84. 2008
    ..We demonstrate that patients infected with Salmonella serotype Typhi isolates with DCS show evidence of a longer time to fever clearance and more frequent treatment failure. Nalidixic acid screening does not detect all isolates with DCS...
  28. ncbi Typhoid fever in the United States, 1999-2006
    Michael F Lynch
    Enteric Diseases Epidemiology Branch, Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F 22, Atlanta, GA 30341, USA
    JAMA 302:859-65. 2009
    ..Typhoid fever in the United States has increasingly been due to infection with antimicrobial-resistant Salmonella ser Typhi. National surveillance for typhoid fever can inform prevention and treatment recommendations...
  29. pmc Oral priming with Salmonella Typhi vaccine strain CVD 909 followed by parenteral boost with the S. Typhi Vi capsular polysaccharide vaccine induces CD27+IgD-S. Typhi-specific IgA and IgG B memory cells in humans
    Rezwanul Wahid
    Center for Vaccine Development, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA
    Clin Immunol 138:187-200. 2011
    Attenuated live oral typhoid vaccine candidate CVD 909 constitutively expresses Salmonella Typhi capsular polysaccharide antigen (Vi)...
  30. ncbi A cluster-randomized effectiveness trial of Vi typhoid vaccine in India
    Dipika Sur
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    N Engl J Med 361:335-44. 2009
    ..Uncertainties about the protective effect of Vi polysaccharide vaccine in children under the age of 5 years and about the vaccine's effect under programmatic conditions have inhibited its use in developing countries...
  31. pmc Characterization of Salmonella enterica derivatives harboring defined aroC and Salmonella pathogenicity island 2 type III secretion system (ssaV) mutations by immunization of healthy volunteers
    Zoe Hindle
    Microscience, Wokingham Berkshire RG41 5TU, United Kingdom
    Infect Immun 70:3457-67. 2002
    ..These data indicate that mutations in type III secretion systems may provide a route to the development of live vaccines in humans and highlight significant differences in the potential use of serovars Typhimurium and Typhi...
  32. ncbi Specimens and culture media for the laboratory diagnosis of typhoid fever
    John Wain
    The Wellcome Trust Clinical Research Unit, Centre for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Infect Dev Ctries 2:469-74. 2008
    ..However, current methods are not fully optimised and sourcing culture media and bottles for culture media may be problematic...
  33. pmc The influence of reduced susceptibility to fluoroquinolones in Salmonella enterica serovar Typhi on the clinical response to ofloxacin therapy
    Christopher M Parry
    Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS Negl Trop Dis 5:e1163. 2011
    ..Data from 540 patients randomised to ofloxacin treatment was analysed to identify an MIC of the infecting organism associated with treatment failure...
  34. ncbi A large outbreak of typhoid fever associated with a high rate of intestinal perforation in Kasese District, Uganda, 2008-2009
    Karen P Neil
    Epidemic Intelligence Service, Scientific Education and Professional Development Office, Centers for Disease Control and Prevention CDC, Atlanta, Georgia, USA
    Clin Infect Dis 54:1091-9. 2012
    Salmonella enterica serovar Typhi (Salmonella Typhi) causes an estimated 22 million typhoid fever cases and 216 000 deaths annually worldwide...
  35. ncbi The diagnosis of typhoid fever in the Democratic Republic of the Congo
    Octavie Lunguya
    National Institute for Biomedical Research, Kinshasa, The Democratic Republic of the Congo
    Trans R Soc Trop Med Hyg 106:348-55. 2012
    ..2% and 40.8% requested the Widal test for treatment follow-up and detection of chronic carriers respectively. Salmonella Typhi was recovered from the blood in 2...
  36. pmc Heterogeneity of multifunctional IL-17A producing S. Typhi-specific CD8+ T cells in volunteers following Ty21a typhoid immunization
    Monica A McArthur
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e38408. 2012
    ....
  37. ncbi Killing of enteric bacteria in drinking water by a copper device for use in the home: laboratory evidence
    V B Preethi Sudha
    Centre for Pharmacognosy and Pharmaceutics, Foundation for Revitalisation of Local Health Traditions FRLHT, 74 2, Jarakabande kaval, Yelahanka via Attur, Karnataka, India
    Trans R Soc Trop Med Hyg 103:819-22. 2009
    Water inoculated with 500-1000 colony forming units/ml of Escherichia coli, Salmonella Typhi and Vibrio cholerae was stored overnight at room temperature in copper pots or in glass bottles containing a copper coil devised by us...
  38. pmc Salmonella enterica serovar typhi uses type IVB pili to enter human intestinal epithelial cells
    X L Zhang
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Infect Immun 68:3067-73. 2000
    ..4 microM prePilS)...
  39. pmc Multiple-locus variable-number tandem-repeat analysis of Salmonella enterica serovar Typhi
    Sophie Octavia
    University of New South Wales, Sydney, NSW, Australia
    J Clin Microbiol 47:2369-76. 2009
    ..We suggest that seven of the nine most polymorphic VNTRs be used as a standardized typing scheme for epidemiological typing...
  40. ncbi Trends in Salmonella enteric serovar Typhi in Nairobi, Kenya from 2004 to 2006
    Doris Mueni Mengo
    Institute of Tropical Medicine and Infectious Diseases, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya
    J Infect Dev Ctries 4:393-6. 2010
    ..Typhoid fever is a global health problem. The World Health Organization (WHO) estimates that the current annual global burden of typhoid is approximately 22 million new cases, 5% of which are fatal...
  41. pmc Comparison of serological test kits for diagnosis of typhoid fever in the Philippines
    Razel L Kawano
    National Reference Laboratory for HIV AIDS, Hepatitis and Other STDs, STD AIDS Cooperative Central Laboratory, Manila, Philippines
    J Clin Microbiol 45:246-7. 2007
    ..TUBEX performed best, achieving 94.7% sensitivity and 80.4% specificity. Typhidot, SD Bioline Typhoid, and Mega Salmonella were less specific and, in most cases, less sensitive...
  42. ncbi Salmonella typhi: from a human pathogen to a vaccine vector
    Xiao Lian Zhang
    Department of Immunology, The State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy and Immune related Diseases, Wuhan University, School of Medicine, Wuhan, China
    Cell Mol Immunol 5:91-7. 2008
    ..This review aims to highlight some of the milestones attained in the fight against the disease from the time S. typhi was seen as a pathogen causing typhoid fever to the use of Salmonella as a vaccine vector...
  43. ncbi Vaccines against typhoid fever
    Carlos A Guzman
    Vaccine Research Group, Division of Microbiology, GBF German Research Centre for Biotechnology, Mascheroder Weg 1, Braunschweig, Germany
    Vaccine 24:3804-11. 2006
    ..The advantages and disadvantages of the various approaches taken in the development of a vaccine against typhoid fever are discussed, along with the potential for future vaccine candidates...
  44. pmc Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18
    Wen Deng
    Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Bacteriol 185:2330-7. 2003
    ..The two strains exhibit differences in prophages, insertion sequences, and island structures. While CT18 carries two plasmids, one conferring multiple drug resistance, Ty2 has no plasmids and is sensitive to antibiotics...
  45. ncbi Typhoid fever vaccines: systematic review and meta-analysis of randomised controlled trials
    Abigail Fraser
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Vaccine 25:7848-57. 2007
    ..Neither vaccine is currently registered for administration to children below 2 years of age. Given the recent finding that typhoid fever also affects infants, development of a conjugate vaccine is warranted...
  46. pmc Identification of a bile-induced exopolysaccharide required for Salmonella biofilm formation on gallstone surfaces
    Robert W Crawford
    Center for Microbial Interface Biology and Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 76:5341-9. 2008
    ..These studies provide new therapeutic targets for preventing asymptomatic serovar Typhi gallbladder carriage...
  47. ncbi Identification of typhoid fever and paratyphoid fever cases at presentation in outpatient clinics in Jakarta, Indonesia
    Albert M Vollaard
    Department of Infectious Diseases, C5 P, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Trans R Soc Trop Med Hyg 99:440-50. 2005
    ....
  48. pmc Navigating the future of bacterial molecular epidemiology
    Stephen Baker
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Viet Nam
    Curr Opin Microbiol 13:640-5. 2010
    ..As genome sequencing, SNP detection and geospatial information become more accessible these methods will continue to transform the way molecular epidemiology is used to study populations of bacterial pathogens...
  49. pmc Vaccination against typhoid fever: present status
    B Ivanoff
    WHO Global Programme for Vaccines and Immunization, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 72:957-71. 1994
    ..The first results are promising, but they must be improved before use in a large-scale study. These strains could be used as live vector to deliver foreign antigens to the intestinal mucosa...
  50. pmc Aptamers that preferentially bind type IVB pili and inhibit human monocytic-cell invasion by Salmonella enterica serovar typhi
    Qin Pan
    Department of Immunology, College of Medicine, Wuhan University, People s Republic of China
    Antimicrob Agents Chemother 49:4052-60. 2005
    ..enterica serovar Typhi bacterial infections, useful both in prevention of infection and in therapeutic treatment...
  51. ncbi From bench to bedside: stealth of enteroinvasive pathogens
    Renee M Tsolis
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, 95616 California, USA
    Nat Rev Microbiol 6:883-92. 2008
    ..Host responses contribute to the clinical presentation of disease and improved understanding of these responses in the laboratory is beginning to bridge the gap between bench and bedside...
  52. pmc Molecular analysis of incHI1 antimicrobial resistance plasmids from Salmonella serovar Typhi strains associated with typhoid fever
    John Wain
    Wellcome Trust Clinical Research Unit, Department of Biological Sciences, Imperial College, London
    Antimicrob Agents Chemother 47:2732-9. 2003
    ..In 1996 a single RFLP type, RFLP7, was found to carry the dfrA7 and sul-1 genes, which were not present on R27 or pHCM1. This plasmid type appears to have a selective advantage over other plasmids with the same resistance phenotype...
  53. pmc Serology of typhoid fever in an area of endemicity and its relevance to diagnosis
    D House
    Department of Biochemistry, Imperial College of Science, Technology and Medicine, Exhibition Road, South Kensington, London SW7 2AZ, United Kingdom
    J Clin Microbiol 39:1002-7. 2001
    ..007). These tests could be of use for the diagnosis of typhoid fever in patients who have clinical typhoid fever but are culture negative or in regions where bacterial culturing facilities are not available...
  54. pmc Efficacy trial of Vi polysaccharide vaccine against typhoid fever in south-western China
    H H Yang
    Guangxi Health and Anti epidemic Centre GHAEC, 80 Taoyuan Road, Nanning, Guangxi 530021, China
    Bull World Health Organ 79:625-31. 2001
    ..To test the efficacy of locally produced Vi vaccine over a time period of longer than one year...
  55. pmc Multidrug-resistant Salmonella enterica serovar paratyphi A harbors IncHI1 plasmids similar to those found in serovar typhi
    Kathryn E Holt
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    J Bacteriol 189:4257-64. 2007
    ..Our data show that these serovar Typhi and Paratyphi A IncHI1 plasmids share highly conserved core DNA and have acquired similar mobile elements encoding antibiotic resistance genes in past decades...
  56. ncbi Evaluation of new-generation serologic tests for the diagnosis of typhoid fever: data from a community-based surveillance in Calcutta, India
    Shanta Dutta
    National Institute of Cholera and Enteric Diseases, P 33 CIT Road, Scheme XM, Beliaghata, P O Box 177, Calcutta 700010, India
    Diagn Microbiol Infect Dis 56:359-65. 2006
    ..There is a need for more efficient rapid diagnostic test for typhoid fever especially during the acute stage of the disease. Until then, culture remains the method of choice...
  57. pmc Identification of in vivo-induced bacterial protein antigens during human infection with Salmonella enterica serovar Typhi
    Jason B Harris
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Infect Immun 74:5161-8. 2006
    ..Serovar Typhi antigens identified by IVIAT warrant further evaluation for their contributions to pathogenesis, and they may have diagnostic, therapeutic, or preventive uses...
  58. pmc Vi polysaccharide of Salmonella typhi targets the prohibitin family of molecules in intestinal epithelial cells and suppresses early inflammatory responses
    Amita Sharma
    Hybridoma Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India
    Proc Natl Acad Sci U S A 101:17492-7. 2004
    Vi capsular polysaccharide (Vi) was first identified as a virulence antigen of Salmonella typhi, the causative agent of typhoid fever in humans; it renders S. typhi resistant to phagocytosis and the action of serum complement...
  59. pmc Characterization of MgtC, a virulence factor of Salmonella enterica Serovar Typhi
    Patricio Retamal
    Departamento de Ciencias Biologicas, Universidad Andres Bello, Santiago, Chile
    PLoS ONE 4:e5551. 2009
    ..Typhi. We suggest that MgtC is the most important virulence factor codified in the SPI-3 of S. Typhi...
  60. ncbi Salmonella typhi, the causative agent of typhoid fever, is approximately 50,000 years old
    Claire Kidgell
    Centre for Molecular Microbiology and Infection, Imperial College of Science, Technology and Medicine, The Flowers Building, Exhibition Road, South Kensington, London SW7 2AY, UK
    Infect Genet Evol 2:39-45. 2002
    A global collection of 26 isolates of Salmonella typhi was investigated by sequencing a total of 3336 bp in seven housekeeping genes. Only three polymorphic sites were found and the isolates fell into four sequence types...
  61. pmc Evolutionary history of Salmonella typhi
    Philippe Roumagnac
    Max Planck Institut für Infektionsbiologie, Department of Molecular Biology, Chariteplatz 1, 10117 Berlin, Germany
    Science 314:1301-4. 2006
    ..Neutral evolution in Typhi appears to reflect the asymptomatic carrier state, and adaptive evolution depends on the rapid transmission of phenotypic changes through acute infections...
  62. pmc The capsule encoding the viaB locus reduces interleukin-17 expression and mucosal innate responses in the bovine intestinal mucosa during infection with Salmonella enterica serotype Typhi
    Manuela Raffatellu
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Ave, Davis, CA 95616 8645, USA
    Infect Immun 75:4342-50. 2007
    ..Our data support the idea that the viaB region plays a role in reducing intestinal inflammation in vivo...
  63. ncbi Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid
    Michael McClelland
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, California 92121, USA
    Nat Genet 36:1268-74. 2004
    ..Loss of function also occurs by mutation in different genes in the same pathway (e.g., in chemotaxis and in the production of fimbriae)...
  64. pmc Combined high-resolution genotyping and geospatial analysis reveals modes of endemic urban typhoid fever transmission
    Stephen Baker
    The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Vietnam
    Open Biol 1:110008. 2011
    Typhoid is a systemic infection caused by Salmonella Typhi and Salmonella Paratyphi A, human-restricted bacteria that are transmitted faeco-orally. Salmonella Typhi and S...
  65. pmc Characterization of candidate live oral Salmonella typhi vaccine strains harboring defined mutations in aroA, aroC, and htrA
    D C Lowe
    Department of Cellular Physiology, The Babraham Institute, Babraham, Cambridge CB2 4AT, Imperial College of Science, Technology and Medicine, London SW7 2AY, United Kingdom
    Infect Immun 67:700-7. 1999
    The properties of two candidate Salmonella typhi-based live oral typhoid vaccine strains, BRD691 (S. typhi Ty2 harboring mutations in aroA and aroC) and BRD1116 (S...
  66. pmc In vivo expression of Salmonella enterica serotype Typhi genes in the blood of patients with typhoid fever in Bangladesh
    Alaullah Sheikh
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    PLoS Negl Trop Dis 5:e1419. 2011
    ..Salmonella enterica serotype Typhi is the cause of typhoid fever. It is a human-restricted pathogen, and few data exist on S. Typhi gene expression in humans...
  67. ncbi Treatment of typhoid fever in the 21st century: promises and shortcomings
    T Butler
    Department of Microbiology and Immunology, Ross University School of Medicine, North Brunswick, NJ 08902, USA
    Clin Microbiol Infect 17:959-63. 2011
    ....
  68. ncbi Enteric fever in Mumbai--clinical profile, sensitivity patterns and response to antimicrobials
    S Jog
    Dept of Infectious Diseases, P D Hinduja National Hospital and Medical Research Centre, Veer Savarkar Marg, Mahim, Mumbai 400016, India
    J Assoc Physicians India 56:237-40. 2008
    ..Our main aim was to study the clinical profile, haematological features of culture proven typhoid cases, the antimicrobial susceptibility pattern of the isolates and the time to defervescence with the treatment received...
  69. pmc Sensitivity and specificity of typhoid fever rapid antibody tests for laboratory diagnosis at two sub-Saharan African sites
    Karen H Keddy
    Enteric Diseases Reference Unit, National Institute for Communicable Diseases of the National Health Laboratory Service, Sandringham, South Africa
    Bull World Health Organ 89:640-7. 2011
    To evaluate three commercial typhoid rapid antibody tests for Salmonella Typhi antibodies in patients suspected of having typhoid fever in Mpumalanga, South Africa, and Moshi, United Republic of Tanzania.
  70. pmc Complete nucleotide sequence and molecular characterization of ViaB region encoding Vi antigen in Salmonella typhi
    Y Hashimoto
    Department of Microbiology, Gifu University School of Medicine, Japan
    J Bacteriol 175:4456-65. 1993
    Plasmid pGBM124, which contains a 14-kb Salmonella typhi chromosomal DNA fragment capable of producing the Vi antigen in Escherichia coli HB101 and ViaB-deleted S. typhi GIFU 10007-3, was studied...
  71. pmc Variation in Salmonella enterica serovar typhi IncHI1 plasmids during the global spread of resistant typhoid fever
    Minh Duy Phan
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    Antimicrob Agents Chemother 53:716-27. 2009
    ..We propose that antibiotic selection acts to maintain resistance genes on the plasmid, but there is also competition between plasmids encoding the same resistance phenotype...
  72. ncbi Enteric fever: a travel medicine oriented view
    Eyal Meltzer
    Center for Geographic Medicine and Department of Medicine C, Sheba Medical Center, Tel Hashomer, Israel
    Curr Opin Infect Dis 23:432-7. 2010
    ..This review aims to describe recent epidemiological trends and developments in diagnosis, treatment and prevention...
  73. ncbi Antimicrobial resistance trends in blood culture positive Salmonella Typhi isolates from Pondicherry, India, 2005-2009
    G A Menezes
    Department of Microbiology, Institute of National Importance, Jawaharlal Institute of Postgraduate Medical Education and Research JIPMER, Pondicherry, India
    Clin Microbiol Infect 18:239-45. 2012
    ..This is most likely to be due to an increased use of ciprofloxacin as a first-line drug of choice over more traditional antimicrobial agents for the treatment of typhoid fever...
  74. ncbi An outbreak of peritonitis caused by multidrug-resistant Salmonella Typhi in Kinshasa, Democratic Republic of Congo
    J J Muyembe-Tamfum
    National Institute for Biomedical Research, Kinshasa, the Democratic Republic of Congo
    Travel Med Infect Dis 7:40-3. 2009
    ..On bacteriological investigation, Salmonella Typhi was isolated from the blood of 11 patients with peritonitis...
  75. ncbi Conformational epitope mapping of OmpC, a major cell surface antigen from Salmonella typhi
    A Arockiasamy
    Department of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, 625 021, India
    J Struct Biol 148:22-33. 2004
    ..a trimer made of 16 stranded beta-barrel monomers, is a major cell surface antigen from the human pathogen Salmonella typhi. The relative stability of the epitopes recognising a Salmonella specific MAb (referred as MPN5) and an ..
  76. pmc High-throughput bacterial SNP typing identifies distinct clusters of Salmonella Typhi causing typhoid in Nepalese children
    Kathryn E Holt
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    BMC Infect Dis 10:144. 2010
    b>Salmonella Typhi (S. Typhi) causes typhoid fever, which remains an important public health issue in many developing countries...
  77. ncbi Use of multilocus variable-number tandem repeat analysis in molecular subtyping of Salmonella enterica serovar Typhi isolates
    Yung Yen Tien
    Department of International Trade, Tamkang University, New Taipei, Taiwan, ROC
    J Med Microbiol 61:223-32. 2012
    ..Because seven of the 11 VNTRs are highly variable, the VNTR markers may only be useful in determining genetic relationships among very closely related isolates in short-term epidemiological studies and not for discerning S. Typhi clones...
  78. pmc Vi antigen biosynthesis in Salmonella typhi: characterization of UDP-N-acetylglucosamine C-6 dehydrogenase (TviB) and UDP-N-acetylglucosaminuronic acid C-4 epimerase (TviC)
    Hua Zhang
    Division of Medicinal Chemistry, College of Pharmacy, and Department of Chemistry and Biochemistry, University of Texas, Austin, Texas 78712, USA
    Biochemistry 45:8163-73. 2006
    Vi antigen, the virulence factor of Salmonella typhi, has been used clinically as a molecular vaccine...
  79. ncbi Etiological agents of bacteraemia and antibiotic susceptibility pattern in Kathmandu Model Hospital
    N M Amatya
    Central Department of Microbiology, TU, Kathmandu, Nepal
    JNMA J Nepal Med Assoc 46:112-8. 2007
    ..Out of 532 culture requests, 123 samples showed evidential microbial growth. The number of isolate of Salmonella typhi, Salmonella paratyphi A and Escherichia coli were 78, 44 and one respectively...
  80. pmc A bivalent vaccine to protect against Streptococcus pneumoniae and Salmonella typhi
    Ying Jie Lu
    Division of Infectious Diseases, Children s Hospital Boston, and Harvard Medical School, Boston, MA 02115, United States
    Vaccine 30:3405-12. 2012
    Pneumococcal and Salmonella typhi infections are two major diseases for children in developing countries. For typhoid fever, licensed Vi polysaccharide vaccines are ineffective in children <2-year old...
  81. pmc Highly resistant Salmonella enterica serovar Typhi with a novel gyrA mutation raises questions about the long-term efficacy of older fluoroquinolones for treating typhoid fever
    Kanika Deshpande Koirala
    Oxford University Clinical Research Unit Patan Academy of Health Sciences, Kathmandu, Nepal
    Antimicrob Agents Chemother 56:2761-2. 2012
    ..The isolation of this organism has serious implications for the long-term efficacy of ciprofloxacin and ofloxacin for typhoid treatment...
  82. ncbi Comparative analysis of the Salmonella typhi and Escherichia coli ompC genes
    J L Puente
    Departamento de Biologia Molecular, Universidad Nacional Autonoma de Mexico
    Gene 83:197-206. 1989
    The nucleotide (nt) sequence of the gene encoding the Salmonella typhi OmpC outer membrane protein, and its deduced amino acid (aa) sequence are presented here. The S...
  83. pmc Capsular Vi polysaccharide antigen in Salmonella enterica serovar typhi isolates
    Geeta Mehta
    J Clin Microbiol 40:1127-8. 2002
  84. ncbi Multidrug-resistant typhoid fever with neurologic findings on the Malawi-Mozambique border
    Emily Lutterloh
    Epidemic Intelligence Service, Scientific Education and Professional Development Program Office, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Clin Infect Dis 54:1100-6. 2012
    ..We investigated an outbreak of unexplained febrile illnesses with neurologic findings, determined to be typhoid fever, along the Malawi-Mozambique border...
  85. ncbi Evaluation of a simple and rapid dipstick assay for the diagnosis of typhoid fever in Indonesia
    M Hussein Gasem
    Department of Medicine, Dr Kariadi Hospital and Faculty of Medicine, Diponegoro University, Semarang, Indonesia
    J Med Microbiol 51:173-7. 2002
    ..most hospitals and health centres have no facilities for culture, a rapid dipstick assay for the detection of Salmonella typhi-specific IgM antibodies was evaluated on serum samples from 127 patients clinically suspected of having ..
  86. pmc Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis and pathogenic convergence with Salmonella typhi
    Wei Qiao Liu
    Genomics Research Center, Harbin Medical University, Harbin, China
    PLoS ONE 4:e4510. 2009
    Although over 1400 Salmonella serovars cause usually self-limited gastroenteritis in humans, a few, e.g., Salmonella typhi and S. paratyphi C, cause typhoid, a potentially fatal systemic infection...
  87. pmc Salmonella typhi in the democratic republic of the congo: fluoroquinolone decreased susceptibility on the rise
    Octavie Lunguya
    National Institute for Biomedical Research, Kinshasa, Democratic Republic of the Congo
    PLoS Negl Trop Dis 6:e1921. 2012
    Drug resistance of Salmonella enterica serovar Typhi (Salmonella Typhi) to first-line antibiotics is emerging in Central Africa...
  88. ncbi Multidrug-resistant typhoid fever: a review
    Syed Ahmed Zaki
    Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, India
    J Infect Dev Ctries 5:324-37. 2011
    ..Since the mid-1980s, MDRTF has caused outbreaks in several countries in the developing world, resulting in increased morbidity and mortality, especially in affected children below five years of age and those who are malnourished...
  89. pmc Comparative proteomic analysis of the PhoP regulon in Salmonella enterica serovar Typhi versus Typhimurium
    Richelle C Charles
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS ONE 4:e6994. 2009
    ..The PhoP regulon is a well studied two component (PhoP/Q) coordinately regulated network of genes whose expression is required for intracellular survival of S. enterica...
  90. pmc Constitutive expression of the Vi polysaccharide capsular antigen in attenuated Salmonella enterica serovar typhi oral vaccine strain CVD 909
    J Y Wang
    Center for Vaccine Development, Division of Infectious Diseases and Tropical Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 68:4647-52. 2000
    ..043) or mice given CVD 908-htrA (9 of 10, P = 0.0065)...
  91. pmc The burden and characteristics of enteric fever at a healthcare facility in a densely populated area of Kathmandu
    Abhilasha Karkey
    Oxford University Clinical Research Unit, Patan Academy of Health Sciences, Lagankhel, Kathmandu, Nepal
    PLoS ONE 5:e13988. 2010
    ..These findings are important for initiating a vaccination scheme and improvements in sanitation. We suggest any such intervention should be implemented throughout the LSMC area...
  92. ncbi Nalidixic acid susceptibility test to screen ciprofloxacin resistance in Salmonella typhi
    Arti Kapil
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 115:49-54. 2002
    ..encountered in endemic areas possibly due to the increase in the levels of resistance to ciprofloxacin in Salmonella typhi. The antimicrobial susceptibility tests for S...
  93. ncbi Cell-mediated immunity and antibody responses elicited by attenuated Salmonella enterica Serovar Typhi strains used as live oral vaccines in humans
    Marcelo B Sztein
    Center for Vaccine Development and Departments of Pediatrics and Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Infect Dis 45:S15-9. 2007
    ..In sum, human immunity to S. Typhi elicited by immunization is unexpectedly broad and complex. However, the immunologic correlates of protection remain largely undefined...
  94. ncbi Antimicrobial evaluation of some medicinal plants for their anti-enteric potential against multi-drug resistant Salmonella typhi
    Phulan Rani
    Department of Biotechnology, Panjab University, Chandigarh 160 014, India
    Phytother Res 18:670-3. 2004
    ..Fifty four plant extracts (methanol and aqueous) were assayed for their activity against multi-drug resistant Salmonella typhi. Strong antibacterial activity was shown by the methanol extracts of Aegle marmelos, Salmalia malabarica, ..
  95. pmc Vi-CRM 197 as a new conjugate vaccine against Salmonella Typhi
    F Micoli
    Novartis Vaccines Institute for Global Health, Via Fiorentina 1, 53100 Siena, Italy
    Vaccine 29:712-20. 2011
    ..The virulence capsular polysaccharide of Salmonella Typhi (Vi) coupled to recombinant mutant Pseudomonas aeruginosa exoprotein A (Vi-rEPA) has been shown to be highly ..
  96. ncbi CVD 908, CVD 908-htrA, and CVD 909 live oral typhoid vaccines: a logical progression
    Carol O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Infect Dis 45:S20-3. 2007
    ..This review summarizes the clinical data that directed the logical progression of this vaccine development strategy...
  97. pmc Safety of live oral Salmonella typhi vaccine strains with deletions in htrA and aroC aroD and immune response in humans
    C O Tacket
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 65:452-6. 1997
    A single-dose, oral Salmonella typhi vaccine strain has been sought as a carrier or vector of cloned genes encoding protective antigens of other pathogens...
  98. pmc Temporal fluctuation of multidrug resistant salmonella typhi haplotypes in the mekong river delta region of Vietnam
    Kathryn E Holt
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS Negl Trop Dis 5:e929. 2011
    ..Typhi isolated from 267 typhoid fever patients in the Mekong delta region participating in a randomized trial conducted between 2004 and 2005...
  99. ncbi Typhoid fever: pathogenesis and disease
    D House
    Centre for Molecular Microbiology and Infection, Imperial College of Science Technology and Medicine, London, UK
    Curr Opin Infect Dis 14:573-8. 2001
    ..In addition, we attempt to put current salmonella research into the context of typhoid fever...
  100. pmc Application of an in vitro infection model and simulation for reevaluation of fluoroquinolone breakpoints for Salmonella enterica serotype typhi
    Brent M Booker
    The University at Buffalo School of Pharmacy and Pharmaceutical Sciences, Applied Pharmacodynamics Labooratory, New York, USA
    Antimicrob Agents Chemother 49:1775-81. 2005
    ....
  101. pmc Priming of Salmonella enterica serovar typhi-specific CD8(+) T cells by suicide dendritic cell cross-presentation in humans
    Rosângela Salerno-Goncalves
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA
    PLoS ONE 4:e5879. 2009
    ..Recent studies in mice have shown that dendritic cells (DC) can either directly (upon uptake and processing of Salmonella) or indirectly (by bystander mechanisms) elicit Salmonella-specific CD8(+) T cells...

Research Grants62

  1. Mucosal Immunity, Vaccines and Microbiota Interplay in Humans and Animal
    Marcelo B Sztein; Fiscal Year: 2013
    ..Given the shortcomings of available measures to successfully control this infection, and its bioterrorism potential, to develop a S. dysenteriae type 1 vaccine is of great importance. ..
  2. Fatty acid related regulation of enteric infectious disease
    FREDRICK JON KULL; Fiscal Year: 2012
    ..analysis has indicated that a number of pathogenic bacteria, including several types of Escherichia coli, Salmonella typhi, Salmonella typhimurium, Shigella flexneri, and Yersinia enterocolitica, contain A/X regulators with ..
  3. Recombinant Attenuated Salmonella Vaccines for Humans
    Roy Curtiss; Fiscal Year: 2012
    ..The numbers of annual deaths due to infections by Salmonella Typhi and S...
  4. Biochemistry and Function of a Novel Bacterial Photosensory Two-Component System
    MELISSA MARKS; Fiscal Year: 2010
    ..Health Organization, over 130,000 cases of cholera (Vibrio cholerae) and 17 million cases of Typhoid fever (Salmonella typhi) occur annually...
  5. Multiplex Serodiagnostic Protein Microarray
    PHILIP LOUIS FELGNER; Fiscal Year: 2012
    ..will fabricate whole proteome microarrays for Coxiella burnetii, Rickettsia prowazekii, Brucella melitensis, Salmonella typhi, and non-homologous proteins from related strains of each agent...
  6. Structures of RNA processing and Silencing Enzymes in Prokaryotes
    Hong Li; Fiscal Year: 2013
    ..influenzae, Helicobacter pylori, Neisseria meningitides, Vibrio vulnificus, Staphylococcus aureus, Salmonella Typhi and Clostridium tetani...
  7. Modular Subunit Vaccine for Salmonella
    MARC KEVIN JENKINS; Fiscal Year: 2011
    ..abstract_text> ..
  8. Functional genomics of human variation to Salmonella invasion
    DENNIS CHUN YONE KO; Fiscal Year: 2013
    ..how human genetic differences contribute to variation in infection by the bacteria that causes typhoid fever, Salmonella typhi. The first aim is to identify human genetic differences that modify invasion of S. typhi into cultured cells...
  9. SIV-specific Mamu-E-restricted CD8+ T cells
    David I Watkins; Fiscal Year: 2012
    ..Mycobacterium tuberculosis (Mtb)-, Cytomegalovirus (CMV)- and Salmonella typhi-specific CD8+ T cells have been shown to recognize peptides bound by HLA-E...
  10. A Humanized Mouse Model of Typhoid Fever
    Ferric C Fang; Fiscal Year: 2012
    ..a novel humanized mouse model of human typhoid and to use this model to identify genetic determinants of Salmonella Typhi virulence...
  11. Organ-specific CD4 T cell responses regulate Salmonella persistence
    James B McLachlan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Typhoid fever, caused by the intracellular bacterium Salmonella typhi, is responsible for more than a half million deaths annually worldwide...
  12. Mucosal live vector vaccine against recurrent Clostridium difficile infections
    James E Galen; Fiscal Year: 2013
    ..difficile antigens will be further tested for protection in mice similarly immunized with he multivalent strain and challenged orogastrically with spores from an epidemic strain of C. difficile. ..
  13. Rapid and sensitive detection of Salmonella from blood, food and feces
    SHARON MEI TENNANT; Fiscal Year: 2013
    ....
  14. Immune Mechanisms of Protection in S. Typhi Vaccines
    Marcelo B Sztein; Fiscal Year: 2013
    ..Typhi, and (3) test the hypothesis that protective MHC class II-, class Ia- and HLA-E-restricted CMI against S. Typhi is determined by a restricted set of epitopes derived from S. Typhi proteins. ..
  15. SALMONELLA ANTIMICROBIAL PEPTIDE RESISTANCE
    John S Gunn; Fiscal Year: 2013
    ..Our proposed work will uncover new therapeutic approaches through a better understanding of these important Salmonella sensory mechanisms. ..
  16. Rabbit model to assess reactogenicity and immunogenicity of Salmonella vaccines
    Kenneth L Roland; Fiscal Year: 2013
    ..This animal model will expand our current knowledge of S. Typhi vaccines by providing a means to test the effects of a wide variety of genetic manipulations on reactogenicity and immunogenicity prior to testing in humans. ..
  17. Virulence factors of Salmonella Typhi
    Jorge E Galan; Fiscal Year: 2012
    ..It is estimated that there are 16,000,000 cases of typhoid fever every year, resulting in 600,000 deaths. Knowledge gained from this research should help develop novel therapeutic and prevention strategies. ..
  18. Probiotics to Enhance Influenza Vaccine Immunogenicity
    Patricia L Hibberd; Fiscal Year: 2013
    ..volunteers suggest that LGG boosts the immune response to mucosally administered vaccines such as oral Salmonella typhi, rotavirus and polio virus...
  19. Development of New Beta-Lactamase Inhibitors for Resistant Category B Food/Water-
    CHRISTOPHER JOHN BURNS; Fiscal Year: 2012
    ..The development of an orally available (-lactamase inhibitor-cefpodoxime combination will offer an important therapeutic option for mass administration in the event of a bioterror attack with a category B agent. ..
  20. Increased resistance to low pH to improve Salmonella vaccine immunogenicity
    Kenneth L Roland; Fiscal Year: 2012
    ..However, many Salmonella Typhi vaccines are more sensitive to acid than the wild-type strain and have poor efficacy...
  21. Molecular Mechanisms of Salmonella typhi Pathogenicity
    Jorge E Galan; Fiscal Year: 2010
    ..abstract_text> ..
  22. A Bioengineerable Self-adjuvating Nanoparticle for Antigen Delivery
    Shiladitya Dassarma; Fiscal Year: 2013
    ..The development of a safe, oral adjuvant and vaccine delivery vehicle which is inexpensive, effective, and shelf-stable should lead to a global revolution in the prevention of infectious diseases. ..
  23. Bacterial Pathogen Amplification & Real-Time Detection
    JACK U REN; Fiscal Year: 2003
    ..If the group had used a more deadly pathogen like Salmonella typhi that causes typhoid fever many people would certainly have died...
  24. ANALYSIS TYPHIMURIUM ADHESION TO PEYERS PATCHES
    ANDREAS BAUMLER; Fiscal Year: 2001
    ..The Peyer's patches also serve as main port of entry during typhoid fever, a disease caused Salmonella typhi in humans...
  25. SYNTHETIC PEPTIDE VACCINES FOR DENTAL CARIES
    Martin Taubman; Fiscal Year: 2005
    ..as determined by TT-GTF peptide conjugate vaccine studies will be expressed recombinantly in attenuated Salmonella typhi vectors which can target these epitopes to appropriate mucosal inductive sites...
  26. Live, oral, heat Stable S. typhi TY21a vaccine
    ERIC PATZER; Fiscal Year: 2006
    ..Aridis' vaccine stabilization and delivery technologies to develop a room temperature stable, live, oral Salmonella typhi Ty21a vaccine in a delivery system, that requires no reconstitution or preparation time, e.g...
  27. SALMONELLA ANTIMICROBIAL PEPTIDE RESISTANCE
    John Gunn; Fiscal Year: 2002
    ..Salmonella typhimurium infection of mice causes a similar illness to, and is a model for, Salmonella typhi infection of humans...
  28. DNA Minor Groove-binding Drugs and Food-borne Pathogens
    MARK PERRELLA; Fiscal Year: 2009
    ..Over the past several years we have been interested in the pathophysiology of endotoxin from Salmonella typhi and Escherichia coli...
  29. PHOP/PHOQ DELETED S TYPHI VACCINE STRAINS
    Elizabeth Hohmann; Fiscal Year: 2002
    ..A Salmonella typhi strain (Ty800) deleted for the phoP/phoQ virulence regulon of Salmonellae is very safe and immunogenic in ..
  30. MOLECULAR MECHANISMS OF BACTERIAL MEDIATED APOPTOSIS
    Claudio Basilico; Fiscal Year: 2002
    ..Recently, both Salmonella typhi and S...
  31. BACTERIAL PATHOGEN GENOME INITIATIVE
    Frederick Blattner; Fiscal Year: 1999
    ..Yersinia pestis KIM, causative agent of plague, Shigella flexneri 2 a, the principle agent of dysentary, and Salmonella typhi Ty2, causing Typhoid fever...
  32. Discovery of Salmonella signature SNPs by microarrays.
    Andrew Sparks; Fiscal Year: 2003
    ..Salmonella is a NIAID Category B pathogen. Worldwide, Salmonella typhi is responsible for 16 million cases of typhoid fever and 600,000 deaths annually...
  33. Development and cGMP Manufacture of a Vitrified Typhoid Vaccine
    SIMS KOCHI; Fiscal Year: 2006
    ..The etiologic agent of typhoid fever, Salmonella typhi (S. typhi), is transmitted to humans by the fecal-oral route through contaminated water or food...
  34. CELLULAR TRAFFICKING TO INFLAMED FEMALE GENITAL MUCOSA
    Kathleen Kelly; Fiscal Year: 2001
    ..mucosa homing T cells and mature dendritic cells will be monitored in volunteers following immunization with Salmonella typhi vaccine via different routes...
  35. VIRULENCE MECHANISMS OF SALMONELLA TYPHI
    ANDREAS BAUMLER; Fiscal Year: 2006
    ..This outcome will be significant because it promises to establish a new paradigm in host pathogen interaction that may be applicable to a number of other capsulated pathogens. [unreadable] [unreadable] [unreadable]..
  36. Live Attenuated Salmonella Vaccine Against Campylobacter
    Kenneth Roland; Fiscal Year: 2005
    ..Live, attenuated Salmonella typhi is the most frequently studied vector for delivering foreign (vaccine) antigens in humans...
  37. Feasibility Evaluation of an Oral Typhoid Fever Vaccine
    LAWRENCE THOMAS; Fiscal Year: 2003
    Ty800 is a live attenuated Salmonella typhi organism intended to be used as a prophylactic single dose oral vaccine for Typhoid fever...
  38. DIAGNOSTIC ASSAYS FOR TYPHOID FEVER
    Felipe Cabello; Fiscal Year: 1993
    The molecular cloning and the expression of the Salmonella typhi 36 kDal porin in Escherichia coli, the sequence analysis of its gene, the preparation of monoclonal antibodies against this antigen, and immunoblots and ..
  39. ROLE OF T CELLS IN IMMUNITY TO SALMONELLA TYPHIMURIUM
    Marc Brodkin; Fiscal Year: 1991
    Experimental murine salmonellosis is accepted as an animal model for human infection with Salmonella typhi, which causes significant worldwide illness...
  40. NOVEL HIV VACCINES
    George Lewis; Fiscal Year: 2005
    ..Env immunogen that elicits a broader spectrum of neutralizing antibodies than gp120 which can be delivered by Salmonella typhi as a DNA vaccine and as a soluble protein immunogen...
  41. Gamma-Delta T cells and Cryptosporidiosis
    Beth Kirkpatrick; Fiscal Year: 2008
    ..These data will advance our understanding of the mucosal immune response to cryptosporidiosis, which will lead to further advances in prevention and therapy. ..
  42. RECOMBINANT & LIVE ORAL SALMONELLA TYPHI HYBRID VACCINES
    Myron Levine; Fiscal Year: 2008
    ..abstract_text> ..
  43. Salmonella Gene Expression in Complex Environments
    Michael McClelland; Fiscal Year: 2004
    ..As a class, these methods should be applicable to studying gene expression in any bacterial or eukaryotic microbial community. ..
  44. BACTERIAL LIVE VECTOR-BASED VACCINE AGAINST MALARIA
    Myron Levine; Fiscal Year: 2004
    ..hypothesis of this research plan is that it will be possible, by appropriate manipulation of attenuated Salmonella typhi and Shigella live vectors, to develop a mucosally administered multivalent vaccine to prevent Plasmodium ..
  45. Immune Responses to Biodefense Vaccines Early in Life
    Marcela F Pasetti; Fiscal Year: 2010
    ..It will also provide knowledge to better understand the mechanisms mediating neonatal-infant immunity to develop more effectivevaccines to prevent diseases early in life. ..
  46. IN VIVO INDUCED ANTIGEN TECHNOLOGY OF AA IN LJP
    Martin Handfield; Fiscal Year: 2003
    ..In vivo induced antigens discovered using this method are excellent candidates for consideration as potential diagnostic tools, new targets for antimicrobial therapy, or for vaccine design. ..
  47. Probabilistic methods to identify noncoding RNA genes
    Elena Rivas; Fiscal Year: 2003
    ..elegans and E. coli. ..
  48. Protective Immunity by Shigella vaccines in humans
    MARCELO SZTEIN; Fiscal Year: 2008
    ..g., integrin alpha4beta7)and (b) expanded effector (Teff) and peripheral memory T cell (TEM)pools. ..
  49. H PYLORI RECOMBINATION AND GASTRIC COLONIZATION
    Martin Blaser; Fiscal Year: 2001
    ..pylori infections. ..
  50. Development of a small molecule screen for PhoP regulon inhibitors in Salmonella
    Jason Harris; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  51. Regulatory and functional RNAs: computational approaches
    Elena Rivas; Fiscal Year: 2003
    ..Inference of RNA function. (3) RNA structural alignments and homology searches. How to improve RNA similarity searches by taking into account the structure as well as the sequence information. ..
  52. CELL-SURFACE PROTEINS IN CAMPYLOBACTER FETUS VIRULENCE
    Martin Blaser; Fiscal Year: 2004
    ..Finally, the data generated can be used to develop a mathematical model of antigenic variation that focuses on the relationship between microbial recombination generating diversity and host selection determining the direction of change. ..
  53. Nonpathogenic Mycobacteria:Anti-Bladder Tumor Therapy
    Glenn Fennelly; Fiscal Year: 2005
    ..abstract_text> ..
  54. Computational methods to identify noncoding RNA genes
    Elena Rivas; Fiscal Year: 2006
    ..abstract_text> ..
  55. Computational approaches to noncoding RNAs
    Elena Rivas; Fiscal Year: 2006
    ..How to improve RNA similarity searches by taking into account the structure as well as the sequence information. (5) RNA-based phylogenetic methods. (6) ncRNA families and RNA databases. [unreadable] [unreadable]..
  56. Development of furanones for treatment of anthrax
    Martin Blaser; Fiscal Year: 2005
    ..In initial studies, spores will be given subcutaneosly. Efficacy parameters will be defined as above. Successful trials can lead to phase I studies in humans, and treatment studies in non-human primates. ..
  57. Stringent response and bmp expression in B. burgdorferi
    Felipe Cabello; Fiscal Year: 2007
    ..burgdorferi from a descriptive paradigm to a paradigm framed by mechanistic and causal interpretations. ..
  58. RNA editing and its inhibition of HIV-1 replication in human macrophage
    Yoshihiko Hoshino; Fiscal Year: 2007
    ..These studies will establish if ADAR1 impacts on viral replication and mutation and will be the basis of further investigation on the impact of drug abuse on the expression of ADAR1. [unreadable] [unreadable] [unreadable]..
  59. Regulatory Networks of Helicobacter pylori
    D Scott Merrell; Fiscal Year: 2011
    ..Our studies will help to shed light on genes involved in the process of surviving in the human body and should provide novel targets for vaccine and therapeutic design. ..
  60. Regulated expression of B. burgdorferi virulence genes
    FELIPE CARDENAS CABELLO; Fiscal Year: 2010
    ..burgdorferi. These tools will be used to identify genes that are potentially responsible for this organism's virulence and which could be targets for new vaccines and antibiotics against Lyme disease. ..