salmonella paratyphi a

Summary

Summary: A serotype of SALMONELLA ENTERICA that causes mild PARATYPHOID FEVER in humans.

Top Publications

  1. ncbi Emerging Salmonella Paratyphi A enteric fever and changing trends in antimicrobial resistance pattern of salmonella in Shimla
    S Verma
    Department of Microbiology, IGMC, Shimla 171 001, India
    Indian J Med Microbiol 28:51-3. 2010
  2. ncbi Antibiogram, phage typing and biotyping of Salmonella Typhi and Salmonella Paratyphi A from Rourkela, Orissa
    Usha Das
    Indian J Med Res 124:109-11. 2006
  3. pmc Alternatives to ciprofloxacin use for enteric Fever, United kingdom
    E John Threlfall
    Emerg Infect Dis 14:860-1. 2008
  4. pmc Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi
    Kathryn E Holt
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    BMC Genomics 10:36. 2009
  5. pmc The sensitivity of real-time PCR amplification targeting invasive Salmonella serovars in biological specimens
    Tran Vu Thieu Nga
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    BMC Infect Dis 10:125. 2010
  6. ncbi Vaccines against typhoid fever
    Carlos A Guzman
    Vaccine Research Group, Division of Microbiology, GBF German Research Centre for Biotechnology, Mascheroder Weg 1, Braunschweig, Germany
    Vaccine 24:3804-11. 2006
  7. ncbi Identification of typhoid fever and paratyphoid fever cases at presentation in outpatient clinics in Jakarta, Indonesia
    Albert M Vollaard
    Department of Infectious Diseases, C5 P, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Trans R Soc Trop Med Hyg 99:440-50. 2005
  8. pmc Multidrug-resistant Salmonella enterica serovar paratyphi A harbors IncHI1 plasmids similar to those found in serovar typhi
    Kathryn E Holt
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    J Bacteriol 189:4257-64. 2007
  9. ncbi Emergence of Salmonella enterica serotype Paratyphi A as a major cause of enteric fever in Kathmandu, Nepal
    Christopher W Woods
    Duke University Medical Center, Durham, NC, USA
    Trans R Soc Trop Med Hyg 100:1063-7. 2006
  10. pmc Efficacy trial of Vi polysaccharide vaccine against typhoid fever in south-western China
    H H Yang
    Guangxi Health and Anti epidemic Centre GHAEC, 80 Taoyuan Road, Nanning, Guangxi 530021, China
    Bull World Health Organ 79:625-31. 2001

Research Grants

Detail Information

Publications158 found, 100 shown here

  1. ncbi Emerging Salmonella Paratyphi A enteric fever and changing trends in antimicrobial resistance pattern of salmonella in Shimla
    S Verma
    Department of Microbiology, IGMC, Shimla 171 001, India
    Indian J Med Microbiol 28:51-3. 2010
    ..Paratyphi A. There was decrease in resistance to ampicillin, cotrimoxazole in 2004 and nalidixic acid beyond 2005 and increase in resistance to cefuroxime. We also documented a decrease in resistance to ciprofloxacin after 2005...
  2. ncbi Antibiogram, phage typing and biotyping of Salmonella Typhi and Salmonella Paratyphi A from Rourkela, Orissa
    Usha Das
    Indian J Med Res 124:109-11. 2006
  3. pmc Alternatives to ciprofloxacin use for enteric Fever, United kingdom
    E John Threlfall
    Emerg Infect Dis 14:860-1. 2008
  4. pmc Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi
    Kathryn E Holt
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    BMC Genomics 10:36. 2009
    ..The accumulation of pseudogenes is a key feature of these and other host-adapted pathogens, and overlapping pseudogene complements are evident in Paratyphi A and Typhi...
  5. pmc The sensitivity of real-time PCR amplification targeting invasive Salmonella serovars in biological specimens
    Tran Vu Thieu Nga
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    BMC Infect Dis 10:125. 2010
    ..Invasive Salmonella serovars, which cause enteric fever, can be commonly cultured from the blood of infected patients. Yet, the isolation of invasive Salmonella serovars from blood is protracted and potentially insensitive...
  6. ncbi Vaccines against typhoid fever
    Carlos A Guzman
    Vaccine Research Group, Division of Microbiology, GBF German Research Centre for Biotechnology, Mascheroder Weg 1, Braunschweig, Germany
    Vaccine 24:3804-11. 2006
    ..The advantages and disadvantages of the various approaches taken in the development of a vaccine against typhoid fever are discussed, along with the potential for future vaccine candidates...
  7. ncbi Identification of typhoid fever and paratyphoid fever cases at presentation in outpatient clinics in Jakarta, Indonesia
    Albert M Vollaard
    Department of Infectious Diseases, C5 P, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Trans R Soc Trop Med Hyg 99:440-50. 2005
    ..Paratyphoid fever (Salmonella paratyphi A) could not be distinguished clinically from typhoid fever...
  8. pmc Multidrug-resistant Salmonella enterica serovar paratyphi A harbors IncHI1 plasmids similar to those found in serovar typhi
    Kathryn E Holt
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    J Bacteriol 189:4257-64. 2007
    ..Our data show that these serovar Typhi and Paratyphi A IncHI1 plasmids share highly conserved core DNA and have acquired similar mobile elements encoding antibiotic resistance genes in past decades...
  9. ncbi Emergence of Salmonella enterica serotype Paratyphi A as a major cause of enteric fever in Kathmandu, Nepal
    Christopher W Woods
    Duke University Medical Center, Durham, NC, USA
    Trans R Soc Trop Med Hyg 100:1063-7. 2006
    ..In contrast, only 21 (36%) of the 58 S. Typhi isolates exhibited a common genotype, which is consistent with endemic disease from multiple sources...
  10. pmc Efficacy trial of Vi polysaccharide vaccine against typhoid fever in south-western China
    H H Yang
    Guangxi Health and Anti epidemic Centre GHAEC, 80 Taoyuan Road, Nanning, Guangxi 530021, China
    Bull World Health Organ 79:625-31. 2001
    ..To test the efficacy of locally produced Vi vaccine over a time period of longer than one year...
  11. ncbi Optimization of pulsed-field gel electrophoresis protocols for Salmonella Paratyphi A subtyping
    Chunxia Chen
    State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 155 Changbai Road, Beijing, China
    Foodborne Pathog Dis 9:325-30. 2012
    ..restriction endonucleases and electrophoresis parameters were compared for the PFGE subtyping by using Salmonella Paratyphi A strain panels...
  12. ncbi Enteric fever in Mumbai--clinical profile, sensitivity patterns and response to antimicrobials
    S Jog
    Dept of Infectious Diseases, P D Hinduja National Hospital and Medical Research Centre, Veer Savarkar Marg, Mahim, Mumbai 400016, India
    J Assoc Physicians India 56:237-40. 2008
    ..Our main aim was to study the clinical profile, haematological features of culture proven typhoid cases, the antimicrobial susceptibility pattern of the isolates and the time to defervescence with the treatment received...
  13. pmc First report of Salmonella enterica serotype paratyphi A azithromycin resistance leading to treatment failure
    Aoife Molloy
    Department of Infectious Diseases, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Clin Microbiol 48:4655-7. 2010
    ..Resistance to fluoroquinolones is common and leads to more frequent use of newer agents like azithromycin. We report the first case of azithromycin resistance and treatment failure in a patient with S. Paratyphi A infection...
  14. ncbi Etiological agents of bacteraemia and antibiotic susceptibility pattern in Kathmandu Model Hospital
    N M Amatya
    Central Department of Microbiology, TU, Kathmandu, Nepal
    JNMA J Nepal Med Assoc 46:112-8. 2007
    ..The number of isolate of Salmonella typhi, Salmonella paratyphi A and Escherichia coli were 78, 44 and one respectively...
  15. ncbi Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid
    Michael McClelland
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, California 92121, USA
    Nat Genet 36:1268-74. 2004
    ..Loss of function also occurs by mutation in different genes in the same pathway (e.g., in chemotaxis and in the production of fimbriae)...
  16. ncbi Conjugate vaccines for enteric fever: proceedings of a meeting organized in New Delhi, India in 2009
    Audino Podda
    Novartis Vaccines Institute for Global Health, 53100 Siena, Italy
    J Infect Dev Ctries 4:404-11. 2010
    ..The role of Salmonella Paratyphi A as a cause of enteric fever was discussed and consensus reached that a bivalent S. Typhi-S...
  17. ncbi Prospective evaluation of a rapid diagnostic test Typhidot for typhoid fever
    Mary V Jesudason
    Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India
    Indian J Med Res 123:513-6. 2006
    ..A simple, reliable and affordable rapid diagnostic test has been a long felt need of the clinicians. We therefore prospectively evaluated the sensitivity and specificity of Typhidot test...
  18. pmc Phase 1 and phase 2 studies of Salmonella enterica serovar paratyphi A O-specific polysaccharide-tetanus toxoid conjugates in adults, teenagers, and 2- to 4-year-old children in Vietnam
    E Y Konadu
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2720, USA
    Infect Immun 68:1529-34. 2000
    ..0001); a second injection did not elicit a booster response. Representative sera from all groups had bactericidal activity that could be adsorbed by S. enterica serovar Paratyphi A LPS...
  19. pmc The burden and characteristics of enteric fever at a healthcare facility in a densely populated area of Kathmandu
    Abhilasha Karkey
    Oxford University Clinical Research Unit, Patan Academy of Health Sciences, Lagankhel, Kathmandu, Nepal
    PLoS ONE 5:e13988. 2010
    ..These findings are important for initiating a vaccination scheme and improvements in sanitation. We suggest any such intervention should be implemented throughout the LSMC area...
  20. pmc Pan-genomic analysis provides insights into the genomic variation and evolution of Salmonella Paratyphi A
    Weili Liang
    State Key Laboratory for Infectious Disease Prevention and Control, and National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People s Republic of China
    PLoS ONE 7:e45346. 2012
    b>Salmonella Paratyphi A (S. Paratyphi A) is a highly adapted, human-specific pathogen that causes paratyphoid fever...
  21. pmc Combined high-resolution genotyping and geospatial analysis reveals modes of endemic urban typhoid fever transmission
    Stephen Baker
    The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Vietnam
    Open Biol 1:110008. 2011
    Typhoid is a systemic infection caused by Salmonella Typhi and Salmonella Paratyphi A, human-restricted bacteria that are transmitted faeco-orally. Salmonella Typhi and S...
  22. ncbi Treatment of enteric fever in children on the basis of current trends of antimicrobial susceptibility of Salmonella enterica serovar typhi and paratyphi A
    V Manchanda
    Department of Clinical Microbiology, Maulana Azad Medical College and Associated Chacha Nehru Children Hospital, Geeta Colony, New Delhi 110 031, India
    Indian J Med Microbiol 24:101-6. 2006
    ....
  23. ncbi Enteric fever in Israeli travelers: a nationwide study
    Eyal Meltzer
    The Infectious Disease Unit and the Center of Geographic Medicine and Tropical Diseases at the Sheba Medical Center, Tel Aviv, Israel
    J Travel Med 12:275-81. 2005
    ..We compared the incidence and clinical and microbiologic findings in travelers returning with EF, according to pretravel vaccination status and vaccine type...
  24. pmc Controlled evaluation of Bactec Peds Plus/F and Bactec lytic/10 anaerobic/F media for isolation of Salmonella enterica serovars typhi and paratyphi A from blood
    Megan E Reller
    Department of Medicine, Children s Hospital Boston, Boston, Massachusetts, USA
    J Clin Microbiol 47:245-6. 2009
    ..The yields from AL and Peds Plus/F media were the same with equal volumes of blood, but recovery was faster from AL medium than Peds Plus/F medium (10.7 and 16.4 h, respectively) (P < 0.001)...
  25. pmc Synthesis, characterization, and immunological properties in mice of conjugates composed of detoxified lipopolysaccharide of Salmonella paratyphi A bound to tetanus toxoid with emphasis on the role of O acetyls
    E Konadu
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 64:2709-15. 1996
    b>Salmonella paratyphi A, the second most common cause of enteric fever in Southeast Asia, is a habitant of and a pathogen for humans only...
  26. ncbi [Multilocus sequence typing and pulsed-field gel electrophoresis analysis of Salmonella Paratyphi A isolates from 2000 to 2008, China]
    Hui Han
    National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
    Zhonghua Yu Fang Yi Xue Za Zhi 44:810-4. 2010
    To analyze molecular and evolution characteristics of Salmonella Paratyphi A isolates from 2000 to 2008, China.
  27. pmc Salmonella paratyphi A rates, Asia
    R Leon Ochiai
    International Vaccine Institute, Kwanak PO Box 14, Seoul, South Korea 151 600
    Emerg Infect Dis 11:1764-6. 2005
    ..Paratyphi A. We compared their incidences by using standardized methods from population-based studies in China, Indonesia, India, and Pakistan...
  28. ncbi Ty21a live oral typhoid vaccine and prevention of paratyphoid fever caused by Salmonella enterica Serovar Paratyphi B
    Myron M Levine
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Infect Dis 45:S24-8. 2007
    ..In the pooled analysis, Ty21a conferred significant protection against paratyphoid B fever (efficacy, 49%; 95% confidence interval, 8%-73%; P=.019)...
  29. ncbi Reduced susceptibility to ciprofloxacin and gyra gene mutation in North Indian strains of Salmonella enterica serotype Typhi and serotype Paratyphi A
    K Renuka
    Department of Microbiology, India Institute of Medical Sciences, New Delhi, India
    Microb Drug Resist 10:146-53. 2004
    ..Hence, it can increase morbidity and mortality due to delay in appropriate antibiotic treatment...
  30. ncbi Recombinant SpaO and H1a as immunogens for protection of mice from lethal infection with Salmonella paratyphi A: implications for rational design of typhoid fever vaccines
    Ping Ruan
    Division of Basic Medical Microbiology, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310003, PR China
    Vaccine 26:6639-44. 2008
    ..However, in recent years a Salmonella paratyphi A strain that is naturally devoid of capsule has caused frequent outbreaks of typhoid fever in Southern ..
  31. ncbi Reactogenicity and immunogenicity of live attenuated Salmonella enterica serovar Paratyphi A enteric fever vaccine candidates
    Kenneth L Roland
    Celldex Therapeutics, Inc, 119 Fourth Avenue, Needham, MA 02494, USA
    Vaccine 28:3679-87. 2010
    ..All DeltaphoPQ strains were immunogenic following a single oral dose. The in vitro profile coupled with the favorable reactogenicity and immunogenicity profiles render MGN10028 a suitable live attenuated Paratyphi A vaccine candidate...
  32. ncbi Molecular characterization of ciprofloxacin-resistant Salmonella enterica serovar Typhi and Paratyphi A causing enteric fever in India
    R Gaind
    Department of Microbiology, Safdarjung Hospital and Assoc VMMC, New Delhi, India
    J Antimicrob Chemother 58:1139-44. 2006
    ..To define the genetic characteristics and resistance mechanisms of clinical isolates of Salmonella enterica serovar Typhi (S. Typhi) and S. enterica serovar Paratyphi A (S. Paratyphi A) exhibiting high-level fluoroquinolones resistance...
  33. ncbi A sudden rise in occurrence of Salmonella paratyphi a infection in Rourkela orissa
    S S Bhattacharya
    Indian J Med Microbiol 25:78-9. 2007
  34. pmc Drug-resistant Salmonella enterica serotype paratyphi A in India
    D S Chandel
    All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Emerg Infect Dis 6:420-1. 2000
    ..Paratyphi A abruptly increased in the New Delhi region. In the first 6 months of 1999, 32% of isolates were resistant to both chloramphenicol and cotrimoxazole and another 13% were resistant to more than two antibiotics...
  35. pmc DNA sequence analysis of DNA gyrase and DNA topoisomerase IV quinolone resistance-determining regions of Salmonella enterica serovar Typhi and serovar Paratyphi A
    Kenji Hirose
    Department of Bacteriology, National Institute of Infectious Diseases, 1 23 1, Toyama, Shinjuku ku, Tokyo, 162 8640, Japan
    Antimicrob Agents Chemother 46:3249-52. 2002
    ....
  36. ncbi Laboratory-based surveillance of paratyphoid fever in the United States: travel and antimicrobial resistance
    Sundeep K Gupta
    Division of Foodborne, Bacterial, and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Infect Dis 46:1656-63. 2008
    ..However, the epidemiologic and laboratory characteristics of paratyphoid fever in the United States have never been studied...
  37. ncbi Multiplex PCR for differential diagnosis of emerging typhoidal pathogens directly from blood samples
    A Ali
    Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering NIBGE, Faisalabad, Pakistan
    Epidemiol Infect 137:102-7. 2009
    ..Tests with several common pathogens confirmed the specificity of the assay. We conclude that the proposed multiplex PCR is rapid, sensitive and specific for the diagnosis of typhoidal pathogens directly from blood samples...
  38. ncbi High-resolution melting assay for the detection of gyrA mutations causing quinolone resistance in Salmonella enterica serovars Typhi and Paratyphi
    Robert Slinger
    Division of Bacteriology, Department of Pathology and Laboratory Medicine, Children s Hospital of Eastern Ontario, Ottawa, ON, Canada K1H 8L1
    Diagn Microbiol Infect Dis 57:455-8. 2007
    ..The presence of gyrA mutations led to small but consistent changes in amplicon melting temperatures that allowed quinolone-resistant isolates to be differentiated from susceptible ones...
  39. pmc PCR method to identify Salmonella enterica serovars Typhi, Paratyphi A, and Paratyphi B among Salmonella Isolates from the blood of patients with clinical enteric fever
    Haim Levy
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Clin Microbiol 46:1861-6. 2008
    ..Blinded testing of 664 Malian and Chilean Salmonella blood isolates demonstrated 100% sensitivity and specificity...
  40. pmc Fluoroquinolone-resistant Salmonella Paratyphi A
    Takuya Adachi
    Emerg Infect Dis 11:172-4. 2005
  41. ncbi Salmonella enterica serovar Paratyphi A and S. enterica serovar Typhi cause indistinguishable clinical syndromes in Kathmandu, Nepal
    Ashish P Maskey
    Patan Hospital, Lagankhel, Lalitpur, Bagmati, Kathmandu, Nepal
    Clin Infect Dis 42:1247-53. 2006
    ..enterica serovar Typhi. There are few data on which to base this assumption, little is known of the serovar's antibacterial susceptibilities, and there is no readily available tolerable vaccination...
  42. ncbi Genetic diversity of Salmonella enterica serovar Paratyphi A from different geographical regions in Asia
    Y L Goh
    Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Appl Microbiol 92:1167-71. 2002
    Subtyping of Salmonella Paratyphi A isolates from India, Pakistan, Indonesia and Malaysia was carried out by pulsed-field gel electrophoresis (PFGE) to assess the extent of genetic diversity of these isolates from different endemic ..
  43. ncbi Salmonella Paratyphi A liver abscess--secondary infection of an amoebic liver abscess?
    A R Jeans
    Department of Infection and Tropical Medicine, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    Travel Med Infect Dis 5:144-6. 2007
    ..We present an unusual case of Salmonella Paratyphi A liver abscess, where secondary bacterial infection of an amoebic liver abscess was suspected.
  44. ncbi The etiology of febrile illness in adults presenting to Patan hospital in Kathmandu, Nepal
    David R Murdoch
    Department of Pathology, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand
    Am J Trop Med Hyg 70:670-5. 2004
    ..Given the lack of reliable clinical predictors, the development of cheap and accurate diagnostic tests are likely to be of great clinical utility in this setting...
  45. ncbi Drug-resistant enteric fever in the UK
    E J Threlfall
    Lancet 367:1576. 2006
  46. ncbi Kathmandu, Nepal: still an enteric fever capital of the world
    Abhilasha Karkey
    Oxford University Clinical Research Unit, Patan Hospital, Lagankhel, Lalitpur, Bagmati, Kathmandu, Nepal
    J Infect Dev Ctries 2:461-5. 2008
    ..Our findings highlight the requirement for better understanding of the disease within the city; in turn, this will aid development of a targeted control strategy...
  47. pmc Molecular analysis of fluoroquinolone-resistant Salmonella Paratyphi A isolate, India
    Satheesh Nair
    The Wellcome Trust Sanger Institute, Cambridgeshire, United Kingdom
    Emerg Infect Dis 12:489-91. 2006
    ....
  48. ncbi Isolated high-level ciprofloxacin resistance in Salmonella enterica subsp. enterica serotype Paratyphi A
    B N Harish
    J Med Microbiol 53:819. 2004
  49. ncbi Re-emergence of Salmonella paratyphi A: a shift in immunity?
    V Padmapriya
    Natl Med J India 16:47-8. 2003
  50. ncbi Further evaluation of a multiplex PCR for differentiation of Salmonella paratyphi A from other salmonellae
    Cindy Shuan Ju Teh
    Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    Jpn J Infect Dis 61:313-4. 2008
    ..We believe that this multiplex PCR is a promising technique for the specific and sensitive detection of S. Paratyphi A in clinical, environmental, and food samples...
  51. pmc Comparisons of predictors for typhoid and paratyphoid fever in Kolkata, India
    Dipika Sur
    1National Institute of Cholera and Enteric Diseases, Kolkata, India
    BMC Public Health 7:289. 2007
    ..such as water improvement or vaccination campaigns are implemented for groups of individuals we were interested whether risk factors not only for the individual but for households, neighbourhoods and larger areas can be recognised?..
  52. pmc A bimodal pattern of relatedness between the Salmonella Paratyphi A and Typhi genomes: convergence or divergence by homologous recombination?
    Xavier Didelot
    Department of Statistics, University of Oxford, Oxford OX1 3SY, United Kingdom
    Genome Res 17:61-8. 2007
    ..We propose that recombination between Typhi and Paratyphi A has allowed the exchange of gene variants that are important for their adaptation to their common ecological niche, the human host...
  53. ncbi LightCycler gyrA mutation assay (GAMA) identifies heterogeneity in GyrA in Salmonella enterica serotypes Typhi and Paratyphi A with decreased susceptibility to ciprofloxacin
    R A Walker
    Health Protection Agency, Specialist and Reference Microbiology Division, Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT, UK
    Int J Antimicrob Agents 22:622-5. 2003
    ..No mutations in gyrA were identified in four Cp(L) strains of S. Typhi that were sensitive to nalidixic acid. The mechanism of decreased susceptibility to ciprofloxacin in these strains is under investigation...
  54. ncbi Vertical transmission of Salmonella paratyphi A
    R Raveendran
    Department of Clinical Microbiology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, India
    Indian J Pediatr 74:784-6. 2007
    ..The role of blood culture in accurate diagnosis and treatment is also discussed...
  55. ncbi Mixed salmonella infection: case report and review of literature
    Subhash C Arya
    J Travel Med 14:356; author reply 356-7. 2007
  56. ncbi Enteric fever due to Salmonella typhi and paratyphi A a neglected and emerging problem
    Henry Wilde
    Vaccine 25:5246-7. 2007
  57. ncbi Enteric fever perspective in India: emergence of high-level ciprofloxacin resistance and rising MIC to cephalosporins
    Malini R Capoor
    J Med Microbiol 56:1131-2. 2007
  58. ncbi Typhoid and paratyphoid fever: a 10-year retrospective study of 41 cases in a Parisian hospital
    E Caumes
    Service des Maladies Infectieuses et Tropicales, Hopital Pitie Salpetriere, Paris, France
    J Travel Med 8:293-7. 2001
    ..criteria were the presence of signs compatible with enteric fever and isolation of Salmonella typhi or Salmonella paratyphi A, B, or C from blood or stool cultures or any other site...
  59. ncbi Comparison of blood, bone marrow aspirate, stool and urine cultures in the diagnosis of enteric fever
    K B Tanyigna
    Department of Medical Microbiology, University of Jos, P.M.B. 2084 Jos-Nigeria
    Niger J Med 10:21-4. 2001
    ..Malaria parasite microscopy should also be done because majority of the suspected enteric fevers may actually only be malaria fever in an environment like Nigeria which is endemic for the two diseases (malaria and typhoid fever)...
  60. ncbi Changing trends in drug resistance among typhoid salmonellae in Rawalpindi, Pakistan
    T Butt
    Microbiology Department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan
    East Mediterr Health J 11:1038-44. 2005
    ..typhi decreased dramatically from 80% to 14%, while in S. paratyphi A resistance increased from 14% to 44%. Susceptibility to the fluoroquinolones decreased in both. No resistance to third generation cephalosporins was detected...
  61. ncbi Re: typhoid fever vaccines: systematic review and meta-analysis of randomised clinical trials
    Subhash C Arya
    Vaccine 26:291. 2008
  62. ncbi Mixed Salmonella infection: case report and review of the literature
    Nelun Perera
    Department of Microbiology, University Hospitals of Leicester, Leicester, UK
    J Travel Med 14:134-5. 2007
    ..We present a case of enteric fever in which both Salmonella Typhi and Salmonella Paratyphi A were isolated from the blood of a patient traveling from India.
  63. ncbi Ciprofloxacin treatment failure in a case of typhoid fever caused by Salmonella enterica serotype Paratyphi A with reduced susceptibility to ciprofloxacin
    Tzonyo Dimitrov
    Department of Medical Laboratories, Microbiology Section, Infectious Diseases Hospital, and Department of Microbiology, Faculty of Medicine, Kuwait University, Safat 13048, Kuwait
    J Med Microbiol 56:277-9. 2007
    ....
  64. ncbi Enteric fever: an Israeli perspective
    Eyal Meltzer
    Infectious Disease Unit, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 9:736-41. 2007
    ..Unfortunately, with the limited efficacy of the current typhoid vaccinations and the increase in multidrug-resistant strains, cases among travelers are expected to continue to increase and become ever challenging to treat...
  65. ncbi In vitro activity of azithromycin, newer quinolones and cephalosporins in ciprofloxacin-resistant Salmonella causing enteric fever
    Malini R Capoor
    Department of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
    J Med Microbiol 56:1490-4. 2007
    ..Typhi and S. Paratyphi was 24 mug ml(-1). Gatifloxacin demonstrated lower resistance (80.8 %) compared with the other quinolones (92-100 %) in S. Typhi. The rise in MIC levels of these antimicrobials is a matter for serious concern...
  66. ncbi Increasing prevalence of Salmonella enterica serotype Paratyphi-A in patients with enteric fever in a periurban slum setting of Kolkata, India
    Anup Palit
    Division of Microbiology, National Institute of Cholera and Enteric Diseases ICMR, Kolkata, India
    Int J Environ Health Res 16:455-9. 2006
    ..Future vaccination strategies should include bivalent vaccines with protection capacities against both ST as well as SPTA...
  67. ncbi Evaluation of the effectiveness and efficiency of the public health management of cases of infection due to Salmonella typhi/paratyphi in North East London
    H L Thomas
    North East London Health Protection Unit, London, UK
    Public Health 120:1188-93. 2006
    ....
  68. ncbi Serodiagnosis of Salmonella enterica serovar Typhi and S. enterica serovars Paratyphi A, B and C human infections
    Henrik Chart
    Laboratory of Enteric Pathogens, Department of Gastrointestinal Infections, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Med Microbiol 56:1161-6. 2007
    ..for the detection of human serum antibodies to the LPS and flagellar antigens of Salmonella Typhi and Salmonella Paratyphi A, B and C, and to the Vi capsular polysaccharide of S. Typhi and S. Paratyphi C...
  69. ncbi Experts call for surveillance of drug-resistant typhoid at a global level
    Khabir Ahmad
    Lancet 359:592. 2002
  70. ncbi Changing trends in the antibiograms of Salmonella isolates at a tertiary care hospital in Hyderabad
    V Lakshmi
    Department of Microbiology, Nizam s Institute of Medical Sciences, Hyderabad 500 082, Andhra Pradesh, India
    Indian J Med Microbiol 24:45-8. 2006
    ..paratyphi A showed a decline. With increasing resistance to ciprofloxacin and the possibility of re-emergence of sensitivity to chloramphenicol, the policy of empirical treatment of enteric fever needs to be rationalized...
  71. ncbi Mixed Salmonella infection
    D Debdas
    Indian J Med Microbiol 26:287. 2008
  72. ncbi [Typhoid and paratyphoid fever]
    Hiroko Sagara
    Department of Infectious Diseases, Yokohama Citizen s Hospital
    Nihon Rinsho 61:395-400. 2003
  73. ncbi Sensitivity pattern of Salmonella serotypes in Northern India
    Vikas Gautam
    Department of Microbiology, PGIMS, Rohtak, India
    Braz J Infect Dis 6:281-7. 2002
    ..The minimum inhibitory concentration (MIC) was also determined for 60 isolates of S. typhi to various commonly used antimicrobial agents...
  74. ncbi [Diagnostic difficulties in febrile travellers returning from the tropics. Two cases of typhoid fever imported from India]
    Elzbieta Kacprzak
    Katedra i Klinika ChorĂ³b Tropikalnych i Pasozytniczych AM, Poznaniu
    Pol Merkur Lekarski 13:509-15. 2002
    ..typhi from peripheral blood cultures. The effectiveness of treatment of choice with ciprofloxacin or ceftriaxone in a case of multidrug-resistant (MDR) strain of S. typhi was documented...
  75. ncbi Effect of socio-economic status, age and sex on antibody titre profile to Salmonella typhi/paratyphi in Ile-Ife, Nigeria
    S B Zailani
    Niger J Med 13:383-7. 2004
    ....
  76. pmc Suboptimal clinical response to ciprofloxacin in patients with enteric fever due to Salmonella spp. with reduced fluoroquinolone susceptibility: a case series
    Robert Slinger
    Division of Infectious Disease, Children s Hospital of Eastern Ontario, 401 Smyth Rd, Ottawa, ON, Canada
    BMC Infect Dis 4:36. 2004
    ..Delayed treatment response to fluoroquinolones has been noted, especially in cases of enteric fever due to such strains. We reviewed the ciprofloxacin susceptibility and clinical outcome of our recent enteric fever cases...
  77. ncbi Screening method for Salmonella enterica serovar Typhi and serovar Paratyphi A with reduced susceptibility to fluoroquinolones by PCR-restriction fragment length polymorphism
    Kenji Hirose
    Department of Bacteriology, National Institute of Infectious Diseases, Shinjuku ku, Tokyo 162 8640, Japan
    Microbiol Immunol 47:161-5. 2003
    ..enterica serovar Typhi and serovar Paratyphi A clinical isolates. This method successfully screened the gyrA mutations of S. enterica serovar Typhi and serovar Paratyphi A with reduced susceptibility to fluoroquinolones...
  78. ncbi Current pattern of enteric fever: a prospective clinical and microbiological study
    Madhoolika Verma
    Department of Paediatrics, Holy Family Hospital, New Delhi
    J Indian Med Assoc 105:582, 584, 586 passim. 2007
    ..Among other drugs, sensitivity to imepenam-100%, azithromycin-49%, aztreonam-65%, amikacin-98%. Nalidixic acid resistance is very high ie, 88%...
  79. ncbi Significance of knowing baseline widal test titres in pediatric population in Delhi
    V L Malhotra
    Lady Hardinge Medical College and Kalawati Saran Children s Hospital, New Delhi
    J Commun Dis 36:70-1. 2004
  80. ncbi Current perspectives of enteric fever: a hospital-based study from India
    Mandeep Walia
    Department of Pediatrics, V M Medical College and Safdarjang Hospital, New Delhi, India
    Ann Trop Paediatr 25:161-74. 2005
    ..The last two decades have seen a change in the pattern of enteric fever with the emergence of multidrug-resistant strains (MDRS), particularly strains resistant to nalidixic acid...
  81. ncbi High level ciprofloxacin resistance in Salmonella enterica isolated from blood
    R Raveendran
    Department of Clinical Microbiology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110 060, India
    Indian J Med Microbiol 26:50-3. 2008
    ..Over the last few years, resistance to ciprofloxacin in Salmonella enterica has become a global concern. The present study was undertaken to find out the susceptibility pattern of Salmonella enterica isolates in our hospital...
  82. pmc Antibiogram pattern and seasonality of Salmonella serotypes in a North Indian tertiary care hospital
    S Mohanty
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India
    Epidemiol Infect 134:961-6. 2006
    ..A knowledge of the seasonal distribution and antibiotic resistance pattern of Salmonella in a particular geographical region is helpful in the delineation of appropriate control measures required for prevention of enteric fever...
  83. ncbi Short-course azithromycin for the treatment of uncomplicated typhoid fever in children and adolescents
    Robert W Frenck
    US Naval Medical Research Unit 3, Cairo, Egypt
    Clin Infect Dis 38:951-7. 2004
    ..No patient who received azithromycin had a relapse, compared with 6 patients who received ceftriaxone. A 5-day course of azithromycin was found to be an effective treatment for uncomplicated typhoid fever in children and adolescents...
  84. ncbi Decreased susceptibility to fluoroquinolones and gyrA gene mutation in the Salmonella enterica serovar Typhi and Paratyphi A isolated in Katmandu, Nepal, in 2003
    Toshiro Shirakawa
    International Center for Medical Research and Treatment, Kobe University School of Medicine, Japan
    Diagn Microbiol Infect Dis 54:299-303. 2006
    ..Typhi and S. Paratyphi A strains with decreased susceptibility to fluoroquinolones...
  85. pmc Value of a single-tube widal test in diagnosis of typhoid fever in Vietnam
    C M Parry
    Wellcome Trust Clinical Research Unit, Cho Quan Hospital, Ho Chi Minh City, Vietnam
    J Clin Microbiol 37:2882-6. 1999
    ..Test patients had suspected typhoid fever and a blood culture positive for Salmonella typhi (n= 1,400) or Salmonella paratyphi A (n = 45)...
  86. pmc Salmonella enterica serovar Typhimurium RamA, intracellular oxidative stress response, and bacterial virulence
    Tahar van der Straaten
    Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Infect Immun 72:996-1003. 2004
    ....
  87. ncbi Minimum inhibitory concentration of carbapenems and tigecycline against Salmonella spp
    Malini R Capoor
    Department of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
    J Med Microbiol 58:337-41. 2009
    ..growth of 90 % of the strains) of the carbapenems (imipenem and meropenem) for Salmonella Typhi and Salmonella Paratyphi A was 0.064 microg ml(-1). MIC(90) of faropenem was 0.25 microg ml(-1) for S. Typhi, S...
  88. ncbi The TUBEX test detects not only typhoid-specific antibodies but also soluble antigens and whole bacteria
    Frankie C H Tam
    Clinical Immunology Unit, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    J Med Microbiol 57:316-23. 2008
    ..Expectedly, Salmonella Paratyphi A (7 strains), Salmonella Typhimurium (1 strain) and Escherichia coli (2 strains) were negative in the test...
  89. ncbi Enteric fever in south China: Guangxi province
    Yang Jin
    Guangxi Center for Disease Prevention and Control, Nanning 530028, Guangxi Province, China
    J Infect Dev Ctries 2:283-8. 2008
    ..This is of particular concern in the post Vi vaccine era due to the emergence and worldwide spread of multi-drug resistant S. Paratyphi A strains and the lack of a vaccine...
  90. ncbi Shelf life extension of minimally processed cabbage and cucumber through gamma irradiation
    Amal Badshah Khattak
    Nuclear Institute for Food and Agriculture, Tarnab, Peshawar, Pakistan
    J Food Prot 68:105-10. 2005
    ..0-kGy irradiation. The D-values for Escherichia coli in cucumber and cabbage were 0.19 and 0.17 kGy, and those for Salmonella Paratyphi A were 0.25 and 0.29 kGy for cucumber and cabbage, respectively.
  91. ncbi Emerging trends in enteric fever in Nepal: 9124 cases confirmed by blood culture 1993-2003
    Ashish P Maskey
    Patan Hospital, GPO Box 252, Kathmandu, Nepal
    Trans R Soc Trop Med Hyg 102:91-5. 2008
    ..hospital in Kathmandu, Nepal to determine the changing burden of salmonella septicaemia, the proportion of Salmonella paratyphi A, and the emergence of drug-resistant organisms...
  92. ncbi Bone marrow culture vs. blood culture in FUO
    A Jha
    Department of Pathology, Manipal College of Medical Sciences, Pokhara, Nepal
    JNMA J Nepal Med Assoc 48:135-8. 2009
    ..Bone marrow culture is considered superior to blood culture in evaluation of FUO. The aim of this study was to compare the usefulness of these two cultures...
  93. ncbi Conservative management of isolated splenic abscess in children
    Subhasis Roy Choudhury
    Department of Pediatric Surgery, Lady Hardinge Medical, College and Kalawati Saran Children s Hospital, New Delhi 110001, India
    J Pediatr Surg 45:372-5. 2010
    ..Isolated splenic abscesses (SAs) are rare in children. We report a single-center experience with emphasis on their diagnosis, etiology, treatment, and outcome...
  94. ncbi Distribution trends of Salmonella serovars in India (2001-2005)
    Yashwant Kumar
    National Salmonella and Escherichia Centre, Central Research Institute, Kasauli 173204, Himachal Pradesh, India
    Trans R Soc Trop Med Hyg 103:390-4. 2009
    ..The most common serovars from humans were Salmonella Typhi (73%) and Salmonella Paratyphi A (24%) among typhoidal serovars, and Salmonella Worthington (28.2%) and Salmonella Typhimurium (22...
  95. ncbi Antibacterial effects of goat and chicken heart tissues against human pathogenic bacteria
    M Sundaramoorthy
    Department of Biotechnology, ARJ College of Engineering and Technology, Mannargudi, India
    Indian J Exp Biol 48:407-14. 2010
    ..The peptides of low molecular weight ( <30 kDa) were also separated from the acid extracted crude proteins of goat and chicken heart tissues by SDS-PAGE after staining with silver nitrate solution...
  96. ncbi Role of enteric fever in ileal perforations: an overstated problem in tropics?
    M R Capoor
    Department of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi 110 029, India
    Indian J Med Microbiol 26:54-7. 2008
    ..To determine the role of enteric fever in ileal perforations...
  97. ncbi Plasmid-mediated quinolone resistance in typhoidal Salmonellae: a preliminary report from South India
    V K Geetha
    Department of Microbiology, Jawaharlal Institute of Post Graduate Medical Education and Research, Gorimedu, Puducherry, India
    Indian J Med Microbiol 32:31-4. 2014
    ....
  98. pmc Gatifloxacin versus ofloxacin for the treatment of uncomplicated enteric fever in Nepal: an open-label, randomized, controlled trial
    Samir Koirala
    Oxford University Clinical Research Unit Nepal, Patan Academy of Health Sciences, Patan Hospital, Patan, Nepal
    PLoS Negl Trop Dis 7:e2523. 2013
    ....
  99. pmc Antimicrobial efficacy and phytochemical analysis of Indigofera trita Linn
    Raju Senthil Kumar
    Department of Pharmaceutical Chemistry, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode, Namakkal 637 205, Tamil Nadu, India
    Afr J Tradit Complement Altern Med 10:518-25. 2013
    ..40 mm), S. epidermidis (14.20 mm), Salmonella paratyphi A (12.80 mm), Streptococcus mutans (12.20 mm), Escherichia coli, Proteus vulgaris, S...
  100. ncbi [Ofloxacin in the treatment of infection caused by Salmonella paratyphi A]
    K Takaki
    Medical Center for Infectious Diseases, Kukuoka City
    Kansenshogaku Zasshi 65:1361-4. 1991
    ..No side effect and no changes of laboratory data were observed and no recurrence was observed clinically and bacteriologically for three months after his discharge...
  101. pmc Cell-associated flagella enhance the protection conferred by mucosally-administered attenuated Salmonella Paratyphi A vaccines
    Orit Gat
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS Negl Trop Dis 5:e1373. 2011
    ..Integral to our efforts to develop a S. Paratyphi A vaccine, we addressed the role of flagella as a potential protective antigen by comparing cell-associated flagella with exported flagellin subunits expressed by attenuated strains...

Research Grants4

  1. CONJUGATE VACCINES DESIGNED TO PREVENT TYPHOID FEVER
    HA KHIEM; Fiscal Year: 2000
    ..trial (Phase 3) Of Vi -rEPA (Vi- recombinant exoprotein A of Pseudomonas aeroginosa) and S para A-TT (Salmonella paratyphi A -tetanus toxoid) investigational vaccines developed by the NICHD, NIH, Vi and S...
  2. BACTERIAL LIVE VECTOR-BASED VACCINE AGAINST MALARIA
    Myron Levine; Fiscal Year: 2004
    ..falciparum, and by these effects working in concert, we will ultimately be able to prevent disease completely in some subjects and to markedly ameliorate disease severity in others. ..
  3. Salmonella Gene Expression in Complex Environments
    Michael McClelland; Fiscal Year: 2004
    ..As a class, these methods should be applicable to studying gene expression in any bacterial or eukaryotic microbial community. ..
  4. RECOMBINANT & LIVE ORAL SALMONELLA TYPHI HYBRID VACCINES
    Myron Levine; Fiscal Year: 2008
    ..abstract_text> ..