salmonella enterica

Summary

Summary: A subgenus of Salmonella containing several medically important serotypes. The habitat for the majority of strains is warm-blooded animals.

Top Publications

  1. pmc Comprehensive identification of Salmonella enterica serovar typhimurium genes required for infection of BALB/c mice
    Roy R Chaudhuri
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    PLoS Pathog 5:e1000529. 2009
  2. pmc Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution
    W Florian Fricke
    Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Bacteriol 193:3556-68. 2011
  3. ncbi Identification of plasmids by PCR-based replicon typing
    Alessandra Carattoli
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Microbiol Methods 63:219-28. 2005
  4. pmc Salmonella bongori provides insights into the evolution of the Salmonellae
    Maria Fookes
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS Pathog 7:e1002191. 2011
  5. pmc Salmonella enterica response regulator SsrB relieves H-NS silencing by displacing H-NS bound in polymerization mode and directly activates transcription
    Don Walthers
    Department of Microbiology and Immunology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 286:1895-902. 2011
  6. pmc Genome sequencing reveals diversification of virulence factor content and possible host adaptation in distinct subpopulations of Salmonella enterica
    Henk C den Bakker
    Department of Food Science, Cornell University, Ithaca, NY 14853, USA
    BMC Genomics 12:425. 2011
  7. pmc Recombination and population structure in Salmonella enterica
    Xavier Didelot
    Department of Statistics, Oxford University, Oxford, United Kingdom
    PLoS Genet 7:e1002191. 2011
  8. ncbi Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica
    D E Heinrichs
    Department of Microbiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Mol Microbiol 30:221-32. 1998
  9. pmc Epitope tagging of chromosomal genes in Salmonella
    S Uzzau
    Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    Proc Natl Acad Sci U S A 98:15264-9. 2001
  10. pmc Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia
    Leigh A Knodler
    Laboratory of Intracellular Parasites and Research Technologies Branch, Microscopy Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 107:17733-8. 2010

Detail Information

Publications382 found, 100 shown here

  1. pmc Comprehensive identification of Salmonella enterica serovar typhimurium genes required for infection of BALB/c mice
    Roy R Chaudhuri
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    PLoS Pathog 5:e1000529. 2009
    ..Defined deletion mutants of several novel targets identified in the TMDH screen are effective live vaccines...
  2. pmc Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution
    W Florian Fricke
    Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Bacteriol 193:3556-68. 2011
    Despite extensive surveillance, food-borne Salmonella enterica infections continue to be a significant burden on public health systems worldwide. As the S...
  3. ncbi Identification of plasmids by PCR-based replicon typing
    Alessandra Carattoli
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Microbiol Methods 63:219-28. 2005
    ..The specificity of the method was tested on a collection of 61 reference plasmids and on 20 Salmonella enterica strains of different serotypes isolated in Italy...
  4. pmc Salmonella bongori provides insights into the evolution of the Salmonellae
    Maria Fookes
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS Pathog 7:e1002191. 2011
    ..This work suggests that S. bongori has inherited the ancestral Salmonella virulence gene set, but has adapted by incorporating virulence determinants that resemble those employed by EPEC...
  5. pmc Salmonella enterica response regulator SsrB relieves H-NS silencing by displacing H-NS bound in polymerization mode and directly activates transcription
    Don Walthers
    Department of Microbiology and Immunology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 286:1895-902. 2011
    ..Because SsrB-dependent promoters are diversely organized, additional mechanisms of transcriptional activation at other loci are likely...
  6. pmc Genome sequencing reveals diversification of virulence factor content and possible host adaptation in distinct subpopulations of Salmonella enterica
    Henk C den Bakker
    Department of Food Science, Cornell University, Ithaca, NY 14853, USA
    BMC Genomics 12:425. 2011
    ..While some studies have suggested the existence of Salmonella enterica subsp. enterica subclades, evidence for these subdivisions has been ambiguous...
  7. pmc Recombination and population structure in Salmonella enterica
    Xavier Didelot
    Department of Statistics, Oxford University, Oxford, United Kingdom
    PLoS Genet 7:e1002191. 2011
    b>Salmonella enterica is a bacterial pathogen that causes enteric fever and gastroenteritis in humans and animals...
  8. ncbi Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica
    D E Heinrichs
    Department of Microbiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Mol Microbiol 30:221-32. 1998
    ..coli and the Ra core type of Salmonella enterica serovar Typhimurium and discuss advances in the understanding of the related biosynthetic pathways...
  9. pmc Epitope tagging of chromosomal genes in Salmonella
    S Uzzau
    Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    Proc Natl Acad Sci U S A 98:15264-9. 2001
    ..the sequences encoding the FLAG and 3xFLAG and influenza virus hemagglutinin epitopes to various genes of Salmonella enterica serovar Typhimurium, including putative and established pathogenic determinants present in prophage genomes...
  10. pmc Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia
    Leigh A Knodler
    Laboratory of Intracellular Parasites and Research Technologies Branch, Microscopy Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 107:17733-8. 2010
    b>Salmonella enterica is an intracellular bacterial pathogen that resides and proliferates within a membrane-bound vacuole in epithelial cells of the gut and gallbladder...
  11. ncbi Recognition of heptameric seed sequence underlies multi-target regulation by RybB small RNA in Salmonella enterica
    Roberto Balbontin
    Departamento de Genetica, Facultad de Biologia, Universidad de Sevilla, 41080 Seville, Spain
    Mol Microbiol 78:380-94. 2010
    ..Altogether, our results indicate that an heptameric 'seed' sequence is sufficient to confer susceptibility to RybB regulation...
  12. ncbi Biosynthesis of O-antigens: genes and pathways involved in nucleotide sugar precursor synthesis and O-antigen assembly
    Gabrielle Samuel
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW 2006, Australia
    Carbohydr Res 338:2503-19. 2003
    ..This review is a summary of the current knowledge on these three groups of genes that comprise the O-antigen gene clusters, focusing on the most extensively studied E. coli and S. enterica gene clusters...
  13. pmc The global consequence of disruption of the AcrAB-TolC efflux pump in Salmonella enterica includes reduced expression of SPI-1 and other attributes required to infect the host
    Mark A Webber
    Antimicrobial Agents Research Group, Division of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    J Bacteriol 191:4276-85. 2009
    ..Using the AcrAB-TolC system as a paradigm multidrug-resistant efflux pump and Salmonella enterica serovar Typhimurium as a model pathogen, we have demonstrated that AcrA, AcrB, and TolC are each required ..
  14. ncbi Identification of the protein acetyltransferase (Pat) enzyme that acetylates acetyl-CoA synthetase in Salmonella enterica
    Vincent J Starai
    Department of Bacteriology, University of Wisconsin Madison, Madison, WI 53726 4087, USA
    J Mol Biol 340:1005-12. 2004
    ..We report the identification of the gene of Salmonella enterica serovar Typhimurium LT2 encoding the major protein acetyltransferase (Pat) enzyme that, in concert with the ..
  15. pmc Methodologies for Salmonella enterica subsp. enterica subtyping: gold standards and alternatives
    Pierre Wattiau
    Veterinary and Agrochemical Research Centre, Highly Pathogenic and Food Borne Zoonoses Unit, Groeselenbergstr 99, B 1180 Brussels, Belgium
    Appl Environ Microbiol 77:7877-85. 2011
    For more than 80 years, subtyping of Salmonella enterica has been routinely performed by serotyping, a method in which surface antigens are identified based on agglutination reactions with specific antibodies...
  16. pmc High resolution clustering of Salmonella enterica serovar Montevideo strains using a next-generation sequencing approach
    Marc W Allard
    Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U, S, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA
    BMC Genomics 13:32. 2012
    ..All new draft genomes were compared to 34 S. Montevideo isolates previously published during an NGS-based molecular epidemiological case study...
  17. pmc Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions
    Jennifer A Lambrecht
    Department of Bacteriology, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 287:3454-61. 2012
    ..Metabolic consequences of lacking this protein in Salmonella enterica and other organisms have been described, but the biochemical function of YjgF remained unknown...
  18. doi Adhesive mechanisms of Salmonella enterica
    Carolin Wagner
    Mikrobiologisches Institut, Universitatsklinikum Erlangen, Erlangen, 91054, Germany
    Adv Exp Med Biol 715:17-34. 2011
    b>Salmonella enterica is an invasive, facultative intracellular pathogen of animal and man with the ability to colonize various niches in diverse host organisms. The pathogenesis of infections by S...
  19. pmc Salmonella enterica serovar gallinarum requires ppGpp for internalization and survival in animal cells
    Jae Ho Jeong
    Department of Microbiology, Chonnam National University Medical College, Gwangju 501 746, South Korea
    J Bacteriol 190:6340-50. 2008
    To elucidate the pathogenic mechanism of Salmonella enterica serovar Gallinarum, we examined the expression of the genes encoded primarily in Salmonella pathogenicity island 1 (SPI-1) and SPI-2...
  20. doi Antimicrobial resistance in typhoidal and nontyphoidal salmonellae
    Christopher M Parry
    Division of Medical Microbiology and Genitourinary Medicine and The National Centre for Zoonosis Research, Faculty of Medicine, University of Liverpool, Liverpool, UK
    Curr Opin Infect Dis 21:531-8. 2008
    ..Recent studies documenting the occurrence and types of resistance, with particular reference to quinolones and extended spectrum cephalosporins, and new approaches to treatment are reviewed...
  21. ncbi Cellular microbiology of intracellular Salmonella enterica: functions of the type III secretion system encoded by Salmonella pathogenicity island 2
    V Kuhle
    Institut fur Klinische Mikrobiologie, Immunologie und Hygiene, FAU Erlangen Nürnberg, Wasserturmstr 3 5, 91054, Erlangen, Germany
    Cell Mol Life Sci 61:2812-26. 2004
    The facultative intracellular pathogen Salmonella enterica resides in a special membrane compartment of the host cell and modifies its host to achieve intracellular survival and proliferation...
  22. doi Supplement 2003-2007 (No. 47) to the White-Kauffmann-Le Minor scheme
    Martine Guibourdenche
    Institut Pasteur, WHO Collaborating Center for Reference and Research on Salmonella, Unité de Biodiversité des Bactéries Pathogènes Emergentes, Paris, France
    Res Microbiol 161:26-9. 2010
    ..2003 and 2007 by the WHO Collaborating Center for Reference and Research on Salmonella: 44 were assigned to Salmonella enterica subspecies enterica, 11 to subspecies salamae, 5 to subspecies arizonae, 8 to subspecies diarizonae, one to ..
  23. pmc Molecular phylogeny of the salmonellae: relationships among Salmonella species and subspecies determined from four housekeeping genes and evidence of lateral gene transfer events
    J R McQuiston
    Program in Population Biology, Ecology and Evolution, Emory University, Atlanta, GA 30322, USA
    J Bacteriol 190:7060-7. 2008
    ..salmonellae are a diverse group of bacteria within the family Enterobacteriaceae that includes two species, Salmonella enterica and Salmonella bongori...
  24. pmc Divergent protein motifs direct elongation factor P-mediated translational regulation in Salmonella enterica and Escherichia coli
    Steven J Hersch
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
    MBio 4:e00180-13. 2013
    ..This work expands the known repertoire of EF-P target motifs and implicates factors beyond polyproline motifs that are required for EF-P-mediated regulation...
  25. pmc Leaf age as a risk factor in contamination of lettuce with Escherichia coli O157:H7 and Salmonella enterica
    M T Brandl
    USDA ARS, WRRC, Produce Safety and Microbiology Research Unit, 800 Buchanan St, Albany, CA 94710, USA
    Appl Environ Microbiol 74:2298-306. 2008
    ..10-fold higher on the young (inner) leaves than on the middle leaves. The growth rates of Salmonella enterica and of the natural bacterial microflora were similarly leaf age dependent...
  26. pmc Antimicrobial susceptibility to azithromycin among Salmonella enterica isolates from the United States
    Maria Sjölund-Karlsson
    National Antimicrobial Resistance Monitoring System, Centers for Disease Control and Prevention, CCID NCZVED DFBMD EDLB, 1600 Clifton Road, Atlanta, GA 30329, USA
    Antimicrob Agents Chemother 55:3985-9. 2011
    ..Seventy-two Salmonella enterica serotype Typhi isolates from humans were also tested...
  27. doi Phenotypic profile linked to inhibition of the major Zn influx system in Salmonella enterica: proteomics and ionomics investigations
    Domenico Ciavardelli
    Center of Excellence on Aging Ce S I, University G D Annunzio, Chieti Pescara, Via Colle dell Ara, Chieti Scalo, 66013 Chieti, Italy
    Mol Biosyst 7:608-19. 2011
    ..The high affinity zinc uptake transporter ZnuABC is the main Zn influx system in Salmonella enterica under conditions of Zn starvation...
  28. doi Spread of Salmonella enterica in the body during systemic infection: unravelling host and pathogen determinants
    Pietro Mastroeni
    Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK
    Expert Rev Mol Med 13:e12. 2011
    b>Salmonella enterica causes a range of life-threatening diseases in humans and animals worldwide. Current treatments for S. enterica infections are not sufficiently effective, and there is a need to develop new vaccines and therapeutics...
  29. pmc Differences in attachment of Salmonella enterica serovars and Escherichia coli O157:H7 to alfalfa sprouts
    J D Barak
    Produce Safety and Microbiological Research, Western Regional Research Center, USDA Agricultural Research Service, Albany, California 94710, USA
    Appl Environ Microbiol 68:4758-63. 2002
    Numerous Salmonella enterica and Escherichia coli O157:H7 outbreaks have been associated with contaminated sprouts. We examined how S. enterica serovars, E...
  30. doi Prevalence and concentration of verocytotoxigenic Escherichia coli, Salmonella enterica and Listeria monocytogenes in the beef production chain: a review
    J R Rhoades
    Laboratory of Food Microbiology and Hygiene, Department of Food Science and Technology, Faculty of Agriculture, Aristotle University of Thessaloniki, P O Box 265, Thessaloniki 54124, Greece
    Food Microbiol 26:357-76. 2009
    This review examines the prevalence of three important pathogens, verocytotoxigenic Escherichia coli (VTEC), Salmonella enterica and Listeria monocytogenes, in cattle and beef from the farm to the final, ready-to-eat product...
  31. doi Cellular aspects of immunity to intracellular Salmonella enterica
    Jonathan Jantsch
    Mikrobiologisches Institut, Universitatsklinikum Erlangen, Erlangen, Germany
    Immunol Rev 240:185-95. 2011
    b>Salmonella enterica is a frequent gastrointestinal pathogen with ability to cause diseases ranging from local gastrointestinal inflammation and diarrhea to life-threatening typhoid fever...
  32. ncbi Evolution of pathogenicity islands of Salmonella enterica
    Michael Hensel
    Institut fur Klinische Mikrobiologie, Immunologie und Hygiene, FAU Erlangen Nürnberg, Wasserturmstr 3 5, D 91054 Erlangen, Germany
    Int J Med Microbiol 294:95-102. 2004
    Virulence genes located on pathogenicity islands play a crucial role in the pathogenesis of Salmonella enterica infections. Salmonella pathogenicity islands (SPI) contribute to host cell invasion and intracellular pathogenesis...
  33. doi DNA supercoiling is differentially regulated by environmental factors and FIS in Escherichia coli and Salmonella enterica
    Andrew D S Cameron
    Department of Microbiology, Moyne Institute of Preventive Medicine, School of Genetics and Microbiology, Trinity College Dublin, Dublin 2, Ireland
    Mol Microbiol 80:85-101. 2011
    Although Escherichia coli and Salmonella enterica inhabit similar niches and employ similar genetic regulatory programmes, we find that they differ significantly in their DNA supercoiling responses to environmental and antibiotic ..
  34. doi A dynamic view of the spread and intracellular distribution of Salmonella enterica
    Pietro Mastroeni
    Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    Nat Rev Microbiol 7:73-80. 2009
    ..We describe here recent studies of Salmonella enterica infections in mice which suggest that bacteria resist the antimicrobial environment inside host cells and ..
  35. pmc Complete genome sequence of Salmonella enterica serovar pullorum RKS5078
    Ye Feng
    Genomics Research Center, Harbin Medical University, Harbin, China
    J Bacteriol 194:744. 2012
    b>Salmonella enterica serovar Pullorum is a chicken-adapted pathogen, causing pullorum disease. Its strict host adaptation has been suspected to result in gene decay...
  36. pmc Contribution of the type VI secretion system encoded in SPI-19 to chicken colonization by Salmonella enterica serotypes Gallinarum and Enteritidis
    Carlos J Blondel
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago, Chile
    PLoS ONE 5:e11724. 2010
    ....
  37. doi Charged residues in the cytoplasmic loop of MotA are required for stator assembly into the bacterial flagellar motor
    Yusuke V Morimoto
    Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Microbiol 78:1117-29. 2010
    ....
  38. pmc Paracoccidioides brasiliensis vaccine formulations based on the gp43-derived P10 sequence and the Salmonella enterica FliC flagellin
    Catarina J M Braga
    Department of Microbiology ICB, University of Sao Paulo, Av Prof Lineu Prestes 1374, Sao Paulo, SP 05008 000, Brazil
    Infect Immun 77:1700-7. 2009
    ..brasiliensis gp43 or the P10 peptide in combination with the Salmonella enterica FliC flagellin, an innate immunity agonist binding specifically to the Toll-like receptor 5, in a murine ..
  39. pmc qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin
    L M Cavaco
    Research Group for Antimicrobial Resistance and Molecular Epidemiology, National Food Institute, Technical University of Denmark, Copenhagen V
    Antimicrob Agents Chemother 53:603-8. 2009
    ..A phylogenetic analysis of all known qnr sequences was performed and showed that qnrD was more closely related to the qnrB variants but formed an independent cluster. To our knowledge, this is the first description of this qnrD gene...
  40. pmc Duplication frequency in a population of Salmonella enterica rapidly approaches steady state with or without recombination
    Andrew B Reams
    Department of Microbiology, College of Biological Sciences, University of California, Davis, California 95616, USA
    Genetics 184:1077-94. 2010
    ..While the reported results were obtained with the bacterium Salmonella enterica, the genetic implications seem likely to be of broader biological relevance.
  41. doi Energy source of flagellar type III secretion
    Koushik Paul
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, Utah 84112, USA
    Nature 451:489-92. 2008
    ..Here we show that flagellar secretion in Salmonella enterica requires the proton motive force (PMF) and does not require ATP hydrolysis by FliI...
  42. pmc The Salmonella enterica pan-genome
    Annika Jacobsen
    Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, Building 208, 2800 Kongens Lyngby, Denmark
    Microb Ecol 62:487-504. 2011
    b>Salmonella enterica is divided into four subspecies containing a large number of different serovars, several of which are important zoonotic pathogens and some show a high degree of host specificity or host preference...
  43. pmc Multilocus sequence typing as a replacement for serotyping in Salmonella enterica
    Mark Achtman
    Environmental Research Institute and Department of Microbiology, University College Cork, Cork, Ireland
    PLoS Pathog 8:e1002776. 2012
    b>Salmonella enterica subspecies enterica is traditionally subdivided into serovars by serological and nutritional characteristics...
  44. pmc Internalization of Salmonella enterica in leaves is induced by light and involves chemotaxis and penetration through open stomata
    Yulia Kroupitski
    Microbial Food Safety Research Unit, Department of Food Science, Agricultural Research Organization, The Volcani Center, Beth Dagan 50250, Israel
    Appl Environ Microbiol 75:6076-86. 2009
    ..Incubation of gfp-tagged Salmonella enterica with iceberg lettuce leaves in the light resulted in aggregation of bacteria near open stomata and invasion ..
  45. pmc The PmrA-regulated pmrC gene mediates phosphoethanolamine modification of lipid A and polymyxin resistance in Salmonella enterica
    Hyunwoo Lee
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Bacteriol 186:4124-33. 2004
    The PmrA/PmrB regulatory system of Salmonella enterica controls the modification of lipid A with aminoarabinose and phosphoethanolamine...
  46. pmc Salmonella enterica serovar Senftenberg human clinical isolates lacking SPI-1
    Qinghua Hu
    Shenzhen Centre for Disease Control and Prevention, Shenzhen, Guangdong Province, China
    J Clin Microbiol 46:1330-6. 2008
    ..Recent studies of Salmonella enterica infection models have demonstrated that enterocolitis and diarrhea in mice and cows can occur independently ..
  47. pmc Analysis of pools of targeted Salmonella deletion mutants identifies novel genes affecting fitness during competitive infection in mice
    Carlos A Santiviago
    Sidney Kimmel Cancer Center, San Diego, CA, USA
    PLoS Pathog 5:e1000477. 2009
    ..We constructed individual deletion mutants in 1,023 Salmonella enterica serovar Typhimurium genes, including almost all genes found in Salmonella but not in related genera...
  48. ncbi Lack of O-antigen is essential for plasminogen activation by Yersinia pestis and Salmonella enterica
    Maini Kukkonen
    Division of General Microbiology, Department of Biosciences, FIN 00014 University of Helsinki, Helsinki, Finland
    Mol Microbiol 51:215-25. 2004
    ..Y. pestis and Salmonella enterica express beta-barrel surface proteases of the omptin family that activate human plasminogen...
  49. pmc Emergence, distribution, and molecular and phenotypic characteristics of Salmonella enterica serotype 4,5,12:i:-
    Andrea I Moreno Switt
    Department of Food Science, Cornell University, Ithaca, New York 14853, USA
    Foodborne Pathog Dis 6:407-15. 2009
    ..represent one of the most common causes of bacterial foodborne illnesses around the world. The species Salmonella enterica contains more than 2500 serotypes, and emergence of new human pathogenic Salmonella strains and serotypes ..
  50. pmc Evolution and population structure of Salmonella enterica serovar Newport
    Vartul Sangal
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Chariteplatz 1, D 10117 Berlin, Germany
    J Bacteriol 192:6465-76. 2010
    Salmonellosis caused by Salmonella enterica serovar Newport is a major global public health concern, particularly because S...
  51. pmc Salmonella enterica serotype Choleraesuis: epidemiology, pathogenesis, clinical disease, and treatment
    Cheng Hsun Chiu
    Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Clin Microbiol Rev 17:311-22. 2004
    ..Among more than 2,000 serotypes, Salmonella enterica serotype Choleraesuis shows the highest predilection to cause systemic infections in humans...
  52. pmc Short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 protein function in Salmonella enterica and Saccharomyces cerevisiae
    Vincent J Starai
    Department of Bacteriology, University of Wisconsin, Madison, Wisconsin 53726 4087, USA
    Genetics 163:545-55. 2003
    ..In Salmonella enterica, SIR2 function was required for activity of the acetyl-CoA synthetase (Acs) enzyme...
  53. pmc A conserved surface loop in type I dehydroquinate dehydratases positions an active site arginine and functions in substrate binding
    Samuel H Light
    Center for Structural Genomics of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States
    Biochemistry 50:2357-63. 2011
    ..We present three crystal structures of the Salmonella enterica type I DHQD that address the functionality of a surface loop that is observed to close over the active site ..
  54. pmc First report of extended-spectrum-beta-lactamase-producing Salmonella enterica isolates in Ireland
    Dearbhaile Morris
    Antimicrob Agents Chemother 50:1608-9. 2006
  55. ncbi The role of cellulose and O-antigen capsule in the colonization of plants by Salmonella enterica
    Jeri D Barak
    Produce Safety and Microbiology Research Unit, United States Department of Agriculture Agricultural Research Service, Albany, CA 94710, USA
    Mol Plant Microbe Interact 20:1083-91. 2007
    ..Tafi), a component of the extracellular matrix responsible for multicellular behavior, are important for Salmonella enterica attachment and colonization of plants...
  56. pmc Genes ycfR, sirA and yigG contribute to the surface attachment of Salmonella enterica Typhimurium and Saintpaul to fresh produce
    Joelle K Salazar
    Institute for Food Safety and Health, Illinois Institute of Technology, Bedford Park, Illinois, United States of America
    PLoS ONE 8:e57272. 2013
    b>Salmonella enterica is a frequent contaminant of minimally-processed fresh produce linked to major foodborne disease outbreaks...
  57. pmc Complex c-di-GMP signaling networks mediate transition between virulence properties and biofilm formation in Salmonella enterica serovar Typhimurium
    Irfan Ahmad
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e28351. 2011
    Upon Salmonella enterica serovar Typhimurium infection of the gut, an early line of defense is the gastrointestinal epithelium which senses the pathogen and intrusion along the epithelial barrier is one of the first events towards ..
  58. pmc An infrequent molecular ruler controls flagellar hook length in Salmonella enterica
    Marc Erhardt
    Departement de Medecine, Universite de Fribourg, Fribourg, Switzerland
    EMBO J 30:2948-61. 2011
    ..In Salmonella enterica, the hook extends 55 nm from the cell surface. FliK, a secreted molecular ruler, controls hook length...
  59. doi pMdT1, a small ColE1-like plasmid mobilizing a new variant of the aac(6')-Ib-cr gene in Salmonella enterica serovar Typhimurium
    María de Toro
    Area de Microbiología Molecular, Centro de Investigación Biomédica de La Rioja CIBIR, Logrono, Spain
    J Antimicrob Chemother 68:1277-80. 2013
    ..To characterize a 5.9 kb aac(6')-Ib-cr-harbouring plasmid that was detected in a clinical Salmonella Typhimurium DT104B strain...
  60. doi Innate immune control of Salmonella enterica serovar Typhimurium: mechanisms contributing to combating systemic Salmonella infection
    Mary Jo Wick
    Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
    J Innate Immun 3:543-9. 2011
    Infections with Salmonella enterica serovars remain a serious problem worldwide...
  61. doi Development of multiplex PCR assay for rapid detection of Riemerella anatipestifer, Escherichia coli, and Salmonella enterica simultaneously from ducks
    Qinghai Hu
    Shanghai Veterinary Research Institute, The Chinese Academy of Agricultural Sciences CAAS, 518 Ziyue Road, Shanghai 200241, PR China
    J Microbiol Methods 87:64-9. 2011
    Three pathogens, Riemerella anatipestifer, Escherichia coli, and Salmonella enterica, are leading causes of bacterial fibrinous pericarditis and perihepatitis in ducks in China and worldwide...
  62. pmc Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates
    Samuel H Light
    Center for Structural Genomics of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 286:3531-9. 2011
    ..present three crystal structures of the type I DHQD from the intestinal pathogens Clostridium difficile and Salmonella enterica. Structures of the enzyme with substrate and covalent pre- and post-dehydration reaction intermediates ..
  63. pmc Integron-mediated multidrug resistance in a global collection of nontyphoidal Salmonella enterica isolates
    Mary G Krauland
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    Emerg Infect Dis 15:388-96. 2009
    b>Salmonella enterica bacteria have become increasingly resistant to antimicrobial agents, partly as a result of genes carried on integrons...
  64. pmc Salmonella enterica bacteraemia: a multi-national population-based cohort study
    Kevin B Laupland
    Department of Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    BMC Infect Dis 10:95. 2010
    b>Salmonella enterica is an important emerging cause of invasive infections worldwide. However, population-based data are limited. The objective of this study was to define the occurrence of S...
  65. pmc Tetracycline and streptomycin resistance genes, transposons, and plasmids in Salmonella enterica isolates from animals in Italy
    Cristina Pezzella
    Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanita, Rome, Italy
    Antimicrob Agents Chemother 48:903-8. 2004
    Fifty-eight multidrug-resistant Salmonella enterica strains of 20 serotypes, isolated from animal sources in Italy, were analyzed for tet(A) and strA-strB, conferring tetracycline and streptomycin resistance, respectively...
  66. pmc Minimal functions and physiological conditions required for growth of salmonella enterica on ethanolamine in the absence of the metabolosome
    Shaun R Brinsmade
    Department of Bacteriology, University of Wisconsin Madison, 53726 4087, USA
    J Bacteriol 187:8039-46. 2005
    During growth on ethanolamine, Salmonella enterica synthesizes a multimolecular structure that mimics the carboxysome used by some photosynthetic bacteria to fix CO(2). In S...
  67. doi Extended-spectrum {beta}-lactamases and AmpC {beta}-lactamases in ceftiofur-resistant Salmonella enterica isolates from food and livestock obtained in Germany during 2003-07
    Irene Rodríguez
    Departamento de Biologia Funcional, Area de Microbiologia, Universidad de Oviedo, 33006 Oviedo, Spain
    J Antimicrob Chemother 64:301-9. 2009
    ..Detection and characterization of extended-spectrum beta-lactamases (ESBLs) and AmpC-encoding genes was conducted in German Salmonella isolated from different sources from 2003 to 2007...
  68. pmc Members of the YjgF/YER057c/UK114 family of proteins inhibit phosphoribosylamine synthesis in vitro
    Jennifer A Lambrecht
    Department of Bacteriology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Biol Chem 285:34401-7. 2010
    ..Analysis of Salmonella enterica strains lacking yjgF has led to a working model in which YjgF functions to remove potentially toxic ..
  69. pmc Evaluation of quinolones for use in detection of determinants of acquired quinolone resistance, including the new transmissible resistance mechanisms qnrA, qnrB, qnrS, and aac(6')Ib-cr, in Escherichia coli and Salmonella enterica and determinations of wil
    L M Cavaco
    Research Group for Antimicrobial Resistance and Molecular Epidemiology, Department for Microbiology and Risk Assessment, National Food Institute, Technical University of Denmark, Bulowsvej 27, Copenhagen V DK 1790, Denmark
    J Clin Microbiol 47:2751-8. 2009
    ..Furthermore, a low concentration of ciprofloxacin (1 microg) in the disks seemed to increase the sensitivity of the disk diffusion assay...
  70. pmc Variant Salmonella genomic island 1 antibiotic resistance gene cluster containing a novel 3'-N-aminoglycoside acetyltransferase gene cassette, aac(3)-Id, in Salmonella enterica serovar newport
    Benoit Doublet
    Unité BioAgresseurs, santé, Environnement, Institut National de la Recherche Agronomique, 37380 Nouzilly, France
    Antimicrob Agents Chemother 48:3806-12. 2004
    ..harbors an antibiotic resistance gene cluster and was previously identified in the multidrug-resistant Salmonella enterica serovars Typhimurium DT104, Agona, Paratyphi B, and Albany...
  71. ncbi Studies of propionate toxicity in Salmonella enterica identify 2-methylcitrate as a potent inhibitor of cell growth
    A R Horswill
    Department of Bacteriology, University of Wisconsin, Madison, Wisconsin 53706 1567, USA
    J Biol Chem 276:19094-101. 2001
    b>Salmonella enterica serovar Typhimurium LT2 showed increased sensitivity to propionate when the 2-methylcitric acid cycle was blocked...
  72. doi TLR2-, TLR4- and Myd88-independent acquired humoral and cellular immunity against Salmonella enterica serovar Typhimurium
    Sabine A Seibert
    Max Planck Institute for Infection Biology, Department of Immunology, Chariteplatz 1, D 10117 Berlin, Germany
    Immunol Lett 127:126-34. 2010
    ..However, their role in the generation of acquired immunity is less clear. Using experimental Salmonella enterica serovar Typhimurium (ST) infection of mice, we determined the role of TLR2, TLR4 and of the TLR adaptor ..
  73. pmc Rapid and highly efficient method for scarless mutagenesis within the Salmonella enterica chromosome
    Kathrin Blank
    Junior Research Group 3, Robert Koch Institute, Wernigerode Branch, Wernigerode, Germany
    PLoS ONE 6:e15763. 2011
    ..The presented approach is very versatile for generating in-frame deletions, point mutations or insertions within bacterial chromosomes...
  74. pmc Development of a multiplex primer extension assay for rapid detection of Salmonella isolates of diverse serotypes
    Elloulu Ben-Darif
    Department of Medical Microbiology, School of Medicine, University of Manchester, Clinical Sciences Building, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom
    J Clin Microbiol 48:1055-60. 2010
    ..Kingdom, based on serotype-specific SNPs identified in the multilocus sequence typing (MLST) database of Salmonella enterica. The SNPs, in genes hemD, thrA, purE, and sucA, acted as surrogate markers for S...
  75. pmc The genome of epsilon15, a serotype-converting, Group E1 Salmonella enterica-specific bacteriophage
    Andrew M Kropinski
    Department of Microbiology and Immunology, Queens University, Kingston, Ontario, Canada K7L 3N6
    Virology 369:234-44. 2007
    The genome sequence of the Salmonella enterica serovar Anatum-specific, serotype-converting bacteriophage epsilon15 has been completed. The nonredundant genome contains 39,671 bp and 51 putative genes...
  76. pmc A whole-genome single nucleotide polymorphism-based approach to trace and identify outbreaks linked to a common Salmonella enterica subsp. enterica serovar Montevideo pulsed-field gel electrophoresis type
    Henk C den Bakker
    Department of Food Science, Cornell University, Ithaca, New York 14853, USA
    Appl Environ Microbiol 77:8648-55. 2011
    ..polymorphism (SNP)-based evolutionary approach to study the epidemiology of a multistate outbreak of Salmonella enterica subsp. enterica serovar Montevideo...
  77. ncbi Envelope instability in DNA adenine methylase mutants of Salmonella enterica
    M Graciela Pucciarelli
    Departamento de Biotecnologia Microbiana, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas CSIC, Campus de Cantoblanco, 28049 Madrid, Spain
    Microbiology 148:1171-82. 2002
    Mutants of Salmonella enterica serovar Typhimurium lacking DNA adenine (Dam) methylase show reduced secretion of invasion effectors encoded in the Salmonella-pathogenicity island 1 (SPI-1)...
  78. doi International spread of an epidemic population of Salmonella enterica serotype Kentucky ST198 resistant to ciprofloxacin
    Simon Le Hello
    Institut Pasteur, unité des bactéries pathogènes entériques, Centre national de référence des Salmonella, World Health Organization WHO Collaborating Centre for Reference and Research on Salmonella, Paris, France
    J Infect Dis 204:675-84. 2011
    ..Wales, Denmark, and the United States identified the recent emergence of multidrug-resistant isolates of Salmonella enterica serotype Kentucky displaying high-level resistance to ciprofloxacin...
  79. pmc Characterization and comparative genomic analysis of a novel bacteriophage, SFP10, simultaneously inhibiting both Salmonella enterica and Escherichia coli O157:H7
    Minjung Park
    Department of Food and Animal Biotechnology, Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Sciences, and Center for Agricultural Biomaterials, Seoul National University, Seoul, South Korea
    Appl Environ Microbiol 78:58-69. 2012
    b>Salmonella enterica and Escherichia coli O157:H7 are major food-borne pathogens causing serious illness. Phage SFP10, which revealed effective infection of both S. enterica and E. coli O157:H7, was isolated and characterized...
  80. pmc Genome sequences of Salmonella enterica serovar typhimurium, Choleraesuis, Dublin, and Gallinarum strains of well- defined virulence in food-producing animals
    Emily J Richardson
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, Scotland, UK
    J Bacteriol 193:3162-3. 2011
    b>Salmonella enterica is an animal and zoonotic pathogen of worldwide importance and may be classified into serovars differing in virulence and host range...
  81. pmc Similarity of genes horizontally acquired by Escherichia coli and Salmonella enterica is evidence of a supraspecies pangenome
    Katherine A Karberg
    Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 108:20154-9. 2011
    ..recently horizontally acquired genes), we found that the plurality of unique genes in Escherichia coli and Salmonella enterica are much more similar to each other than are their vertically inherited genes. We conclude that E...
  82. doi Salmonella enterica as a vaccine carrier
    Wael Abdel Halim Hegazy
    Abteilung Mikrobiologie, Fachbereich Biologie chemie, Universität Osnabrück Barbarastrasse 11, 49076 Osnabruck, Germany
    Future Microbiol 7:111-27. 2012
    b>Salmonella enterica is an invasive, facultative intracellular gastrointestinal pathogen causing human diseases such as gastroenteritis and typhoid fever...
  83. pmc Adaptation and preadaptation of Salmonella enterica to Bile
    Sara B Hernández
    Departamento de Genetica, Universidad de Sevilla, Sevilla, Spain
    PLoS Genet 8:e1002459. 2012
    ..This study describes mechanisms employed by the bacterium Salmonella enterica to survive bile...
  84. pmc A multi-pronged search for a common structural motif in the secretion signal of Salmonella enterica serovar Typhimurium type III effector proteins
    Garry W Buchko
    Fundamental and Computational Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Mol Biosyst 6:2448-58. 2010
    ..To address these issues a peptide corresponding to the secretion signal for Salmonella enterica serovar Typhimurium effector SseJ was synthesized (residues 1-30, SseJ) along with scrambled peptides of ..
  85. doi Increased detection of extended spectrum beta-lactamase producing Salmonella enterica and Escherichia coli isolates from poultry
    Cindy Dierikx
    Department of Bacteriology and TSEs, Central Veterinary Institute of Wageningen UR, Lelystad, The Netherlands
    Vet Microbiol 145:273-8. 2010
    ..Minimum Inhibitory Concentrations (MICs) for cefotaxime observed since 2003, beta-lactamase genes of 22 Salmonella enterica and 22 Escherichia coli isolates from broilers in 2006 showing this phenotype were characterized by ..
  86. pmc Rapid oligonucleotide-based recombineering of the chromosome of Salmonella enterica
    Roman G Gerlach
    Infektionsbiologische Abteilung im Mikrobiologischen Institut, Universitatsklinikum Erlangen, Wasserturmstr 3 5, D 91054 Erlangen, Germany
    Appl Environ Microbiol 75:1575-80. 2009
    ..the use of this approach for the generation of scarless in-frame deletions in chromosomal genes of Salmonella enterica. Furthermore, we describe rapid site-directed mutagenesis within bacterial chromosomes without any ..
  87. pmc Role of nucleoid-associated proteins Hha and H-NS in expression of Salmonella enterica activators HilD, HilC, and RtsA required for cell invasion
    Igor N Olekhnovich
    Department of Microbiology, University of Virginia School of Medicine, PO Box 800734, Charlottesville, VA 22908 0734, USA
    J Bacteriol 189:6882-90. 2007
    The coordinate expression of Salmonella enterica invasion genes on Salmonella pathogenicity island 1 is under the control of the complex circuits of regulation that involve the AraC/XylS family transcriptional activators HilD, HilC, and ..
  88. doi Packed with Salmonella--investigation of an international outbreak of Salmonella Senftenberg infection linked to contamination of prepacked basil in 2007
    Lorenzo Pezzoli
    European Programme for Intervention Epidemiology Training EPIET, European Centre for Disease Control ECDC, Stockholm, Sweden
    Foodborne Pathog Dis 5:661-8. 2008
    ..Microbiological evidence suggested an association between contamination of fresh basil and the cases of Salmonella Senftenberg infection, leading to withdrawal of basil from all potentially affected batches from the U.K. market...
  89. pmc Relationships of the Escherichia coli O157, O111, and O55 O-antigen gene clusters with those of Salmonella enterica and Citrobacter freundii, which express identical O antigens
    Gabrielle Samuel
    School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia
    J Bacteriol 186:6536-43. 2004
    Escherichia coli O157, Salmonella enterica O30, and Citrobacter freundii F90 have identical O-antigen structures, as do E. coli O55 and S. enterica O50. The O-antigen gene cluster sequences for E. coli O157 and E...
  90. pmc Structural insight into the regulatory mechanisms of interactions of the flagellar type III chaperone FliT with its binding partners
    Katsumi Imada
    Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 107:8812-7. 2010
    ....
  91. pmc Fitness of Salmonella enterica serovar Thompson in the cilantro phyllosphere
    Maria T Brandl
    Produce Safety and Microbiology Research Unit, Agricultural Research Service, U S Department of Agriculture, 800 Buchanan Street, Albany, CA 94710, USA
    Appl Environ Microbiol 68:3614-21. 2002
    The epiphytic fitness of Salmonella enterica was assessed on cilantro plants by using a strain of S. enterica serovar Thompson that was linked to an outbreak resulting from cilantro...
  92. pmc PoxA, yjeK, and elongation factor P coordinately modulate virulence and drug resistance in Salmonella enterica
    William Wiley Navarre
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Mol Cell 39:209-21. 2010
    ..encoding a putative 2,3-beta-lysine aminomutase, that is critical for virulence and stress resistance in Salmonella enterica. Salmonella poxA and yjeK mutants share extensive phenotypic pleiotropy, including attenuated virulence in ..
  93. pmc Salmonella enterica virulence genes are required for bacterial attachment to plant tissue
    Jeri D Barak
    USDA, ARS, WRRC, Produce Safety and Microbiology, 800 Buchanan St, Albany, CA 94710, USA
    Appl Environ Microbiol 71:5685-91. 2005
    Numerous Salmonella enterica food-borne illness outbreaks have been associated with contaminated vegetables, in particular sprouted seeds, and the incidence of reported contamination has steadily risen...
  94. pmc Colonization of Arabidopsis thaliana with Salmonella enterica and enterohemorrhagic Escherichia coli O157:H7 and competition by Enterobacter asburiae
    Michael B Cooley
    Produce Safety and Microbiology Research Unit, Western Regional Research Center, Agricultural Research Service, U S Department of Agriculture, Albany, California 94710, USA
    Appl Environ Microbiol 69:4915-26. 2003
    Enteric pathogens, such as Salmonella enterica and Escherichia coli O157:H7, have been shown to contaminate fresh produce. Under appropriate conditions, these bacteria will grow on and invade the plant tissue...
  95. ncbi Bactericidal activities of plant essential oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica
    Mendel Friedman
    Western Regional Research Center, Agricultural Research Service, U S Department of Agriculture, Albany, California 94710, USA
    J Food Prot 65:1545-60. 2002
    ..and 23 oil compounds against Campylobacter jejuni, Escherichia coli O157:H7, Listeria monocytogenes, and Salmonella enterica obtained from food and clinical sources...
  96. pmc Thiol peroxidase protects Salmonella enterica from hydrogen peroxide stress in vitro and facilitates intracellular growth
    Sarah A Horst
    Department of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Bacteriol 192:2929-32. 2010
    ..Here we describe an additional peroxiredoxin, Tpx, in Salmonella enterica and show that a single tpx mutant is susceptible to exogenous hydrogen peroxide (H(2)O(2)), that it has a ..
  97. pmc Effect of the O-antigen length of lipopolysaccharide on the functions of Type III secretion systems in Salmonella enterica
    Stefanie U Hölzer
    Mikrobiologisches Institut, Universitatsklinikum Erlangen, Erlangen, Germany
    Infect Immun 77:5458-70. 2009
    The virulence of Salmonella enterica critically depends on the functions of two type III secretion systems (T3SS), with the Salmonella pathogenicity island 1 (SPI1)-encoded T3SS required for host cell invasion and the SPI2-T3SS enabling ..
  98. pmc Novel virulence gene and clustered regularly interspaced short palindromic repeat (CRISPR) multilocus sequence typing scheme for subtyping of the major serovars of Salmonella enterica subsp. enterica
    Fenyun Liu
    Department of Food Science, The Pennsylvania State University, 326 Food Science Building, University Park, PA 16802, USA
    Appl Environ Microbiol 77:1946-56. 2011
    b>Salmonella enterica subsp. enterica is the leading cause of bacterial food-borne disease in the United States. Molecular subtyping methods are powerful tools for tracking the farm-to-fork spread of food-borne pathogens during outbreaks...
  99. ncbi Salmonella entry into host cells: the work in concert of type III secreted effector proteins
    D Zhou
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Microbes Infect 3:1293-8. 2001
    Upon contact with intestinal epithelial cells, Salmonella enterica serovar spp. inject a set of bacterial proteins into host cells via the bacterial SPI-1 type III secretion system...
  100. ncbi Regulation of enteric endophytic bacterial colonization by plant defenses
    A Leonardo Iniguez
    University of Wisconsin Madison, Department of Agronomy, Madison 53706, USA
    Mol Plant Microbe Interact 18:169-78. 2005
    ..Others, such as Salmonella enterica serovar Typhimurium (S. typhimurium), are human pathogens that contaminate raw produce...
  101. ncbi Differential interaction of Salmonella enterica serovars with lettuce cultivars and plant-microbe factors influencing the colonization efficiency
    Michel M Klerks
    Wageningen University and Research Centre, Plant Research International BV, Wageningen, The Netherlands
    ISME J 1:620-31. 2007
    ..This research describes the differential interaction of human pathogenic Salmonella enterica with commercially available lettuce cultivars...

Research Grants74

  1. Integrated Microfluidic Platform for Point-of-Care Serodiagnostics
    Xiaowu Liang; Fiscal Year: 2013
    ..priority agents (Brucella melitensis, Francisella tularensis, Burkholderia pseudomallei, Coxiella burnetii, Salmonella enterica typhi, Rickettsia rickettsii, Orientia tsutsugamushi, Toxoplasma gondii, M...
  2. Mucosal Immunity, Vaccines and Microbiota Interplay in Humans and Animal
    Marcelo B Sztein; Fiscal Year: 2013
    ..on in-depth studies of 3 major gram negative bacterial human pathogens including Helicobacter pylori, Salmonella enterica serovar Typhi and Shigella, each primarily affecting a distinct major segment of the Gl tract (i.e...
  3. Enhanced Membrane Systems for Supplying Quality Drinking Water
    Andrew Feiring; Fiscal Year: 2013
    ..Enterococcus Faecalis, MS2 bacteriophage Poliovirus, Cryptosporidium parvum, Legionelle pneumophila, and Salmonella enterica plus specific chemicals, phenol, and humic acid), Cryptosporidium or appropriate surrogate...
  4. Intestinal Inflammation Induced by Pathogens
    Beth A McCormick; Fiscal Year: 2013
    ..event of massive transepithelial migration of PMNs occurs in the acute phase of gastroenteritis induced by Salmonella enterica serovar Typhimurium (salmonellosis)...
  5. Transcriptional Regulation by a Deacetylase, CobB, in a Periodontopathogen
    DAVID J KOLODRUBETZ; Fiscal Year: 2013
    ..The bacterial Sir2 homologue is called CobB. In Salmonella enterica, this deacetylase has been shown to regulate the enzymatic activity of several enzymes in intermediary ..
  6. Regulation of Streptomyces differentiation and antibiotic production by SoxR
    Monica Chander; Fiscal Year: 2010
    ..SoxR has traditionally been known as the mediator of an oxidative stress response in Escherichia coli and Salmonella enterica, but this role may be restricted to enteric bacteria...
  7. Novel anti-toxin compounds against Yersinia infections
    Maurizio Pellecchia; Fiscal Year: 2010
    ..outside the scope of the current application, supporting efforts on understanding how Yersinia pestis, Salmonella enterica, Francisella tularensis, Chlamydia psiticai, and Strep...
  8. Modular Subunit Vaccine for Salmonella
    MARC KEVIN JENKINS; Fiscal Year: 2011
    b>Salmonella enterica serovar Typhi causes disease in millions of individuals who ingest contaminated food or water. Ingested S...
  9. Effects of apoptotic epithelial cell engulfment on mucosal inflammation
    Peter B Ernst; Fiscal Year: 2010
    ..In contrast, cells that undergo apoptosis when they carry an intracellular infection with Salmonella enterica serovar Typhimurium may act as a microbial "Trojan horse" that transports internalized bacteria into the ..
  10. The Role of PtdIns-5-P in Cell Function and Signaling
    LUCIA RAMEH-PLANT; Fiscal Year: 2012
    ..due to the activity of the bacterial virulence factors IpgD (from Shigella flexneri) and SigD/SopB (from Salmonella enterica), which are phosphatases that use PI-4,5-P2 as substrate...
  11. Optimization of novel pyranopyridine efflux pump inhibitors
    Son Truong Nguyen; Fiscal Year: 2013
    ..the antibacterial activity of FQ and beta-lactam antibiotics against Escherichia coli, Shigella flexneri, Salmonella enterica, Enterobacter cloacae, and Klebsiella pneumoniae by inhibiting the major efflux pump in these organisms (..
  12. The Electrochemistry of Diheme Cytochrome c Peroxidases
    Sean J Elliott; Fiscal Year: 2010
    ..Further, our study of triheme CCPs will elucidate the CCP machinery which is unique to pathogens such as Salmonella enterica and Yersinia pestis, providing new insights into their biochemical pathways.
  13. GENETIC CONTROL OF NITRATE RESPIRATION IN E. COLI
    Valley J Stewart; Fiscal Year: 2010
    Enterobacteria such as Escherichia coli and Salmonella enterica are facultative aerobes, and when cultured in the absence of oxygen can use a variety of alternative respiratory oxidants...
  14. The role of PhoP/PhoQ-regulated phospholipid alterations in Salmonella pathogenes
    ZACHARY DALEBROUX; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Salmonella enterica is a Gram-negative pathogen of worldwide importance causing a variety of diseases including typhoid fever, enterocolitis and bacteremia...
  15. Design and mechanistic studies of mimics of antimicrobial peptides
    William F Degrado; Fiscal Year: 2012
    ..activity of the peptides against a panel of Gram negative and positive bacteria including Escherichia coli, Salmonella enterica, Pseudomonas aeruginosa, and Staphylococcus aureus;4) measuring in vivo activity versus S. aureus and P...
  16. Silencing and Counter-Silencing of Salmonella Virulence Genes
    Ferric C Fang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pathogenic bacteria such as Salmonella enterica contain horizontally acquired DNA on plasmids or genomic islands that play a critically important role in host-pathogen interactions...
  17. One Health;Epidemiology of natural and deliberate contaminants (infectious and t
    Susan Sanchez; Fiscal Year: 2013
    ..we are currently participating in another cooperative agreement with the FDA assessing the presence of Salmonella enterica sbsp...
  18. Identification of Salmonella Genes Important for Systemic Colonization
    Helene L Andrews-Polymenis; Fiscal Year: 2012
    ..b>Salmonella enterica serotype Typhimurium is an appropriate model to determine the requirements for systemic infection by NTS as ..
  19. Targeting host deubiquitinases for broad spectrum anti-infective therapy
    Christiane Wobus; Fiscal Year: 2013
    ..against different classes of pathogens, including: category B bacteria (MRSA, Listeria monocytogenes, Salmonella enterica serovar Typhimurium);viruses (murine and human norovirus, encephalomyocarditis virus, Sindbis virus, La ..
  20. A Humanized Mouse Model of Typhoid Fever
    Ferric C Fang; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Salmonella enterica sv. Typhi (S. Typhi) is the etiologic agent of typhoid fever in humans and can cause life-threatening infection in normal hosts...
  21. Mucosal live vector vaccine against recurrent Clostridium difficile infections
    James E Galen; Fiscal Year: 2013
    ..Significant progress has been made in the development of attenuated Salmonella enterica serovar Typhi live vector vaccines...
  22. Comprehensive Mapping and Annotation of the E. coli Transcriptome
    Barry L Wanner; Fiscal Year: 2010
    ..Similar procedures will be used to generate whole transcriptome maps of Salmonella enterica serovar Typhimurium during growth in vitro and following infection of cultured macrophages and epithelial ..
  23. Salmonella SopA is a functional mimicry of eukaryotic E3 protein ubiquitin ligase
    Daoguo Zhou; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Salmonella enterica serovar Typhimurium causes mild gastroenteritis and more severe systematic infections in both humans and domestic animals...
  24. Hemophagocytic Macrophages and Systemic Salmonella Infection
    CORRELLA DETWEILER; Fiscal Year: 2013
    ..b>Salmonella enterica, a species of gram-negative bacteria that includes the causative agent of human typhoid fever, resides ..
  25. MOLECULAR AND FUNCTIONAL ANALYSES OF THE PMRA/PMRB REGULATORY SYSTEM
    EDUARDO GROISMAN; Fiscal Year: 2013
    ..In Salmonella enterica, which is the etiologic agent of typhoid fever and gastroenteritis, many of these LPS modifications are ..
  26. Salmonella polymicrobial interactions
    BRIAN M AHMER; Fiscal Year: 2012
    ..observed that swine infected with Yersinia enterocolitica are at increased risk to be colonized with Salmonella enterica. Given that Salmonella is one of the world's most significant pathogens, it is important to determine ..
  27. Evaluation of Protein Channel-Attenuated Salmonella Vaccines
    Xinghong Yang; Fiscal Year: 2010
    ..b>Salmonella enterica is a disease that causes a variety of food and water-borne illnesses, such as gastroenteritis and typhoid ..
  28. Assembly of bacterial cytoplasmic protein complexes measured by LRET
    ROBERT D RENTHAL; Fiscal Year: 2013
    ..Terbium uptake will also be measured in Salmonella enterica and Vibrio cholerae. If terbium uptake similar to E...
  29. Immature myeloid cells as targets for therapeutics to bacterial infection
    ADRIANUS WILHELMUS MARIA VAN DER VELDEN; Fiscal Year: 2013
    ..preliminary data demonstrating a large response of MDSC in mice infected with the bacterial pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium)...
  30. Rapid and sensitive detection of Salmonella from blood, food and feces
    SHARON MEI TENNANT; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Salmonella enterica serovar Typhi and S...
  31. Microbiota Outgrowth by Salmonella
    ANDREAS J BAUMLER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Salmonella enterica serotype Typhimurium (S. typhimurium) causes gastroenteritis, a diarrheal illness characterized by acute intestinal inflammation...
  32. Elucidation and Evolutionary Potential of a Latent Pathway for PLP Synthesis
    Shelley D Copley; Fiscal Year: 2013
    ..Aim 3 will examine how the resources available in the metabolic network of Salmonella enterica can be used to meet the challenge of synthesizing PLP when the normal pathway is disabled.
  33. Immune Mechanisms of Protection in S. Typhi Vaccines
    Marcelo B Sztein; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Typhoid fever, caused by Salmonella enterica serovar Typhi (S. Typhi), remains a major public health problem worldwide...
  34. STRUCTURE AND FUNCTION OF RESPONSE REGULATOR PROTEINS
    Ann M Stock; Fiscal Year: 2013
    ..g. Mycobacterium tuberculosis, Staphylococcus aureus, Salmonella enterica) infect their hosts...
  35. Role of Host Lipids in Salmonella Replication Within Hemophagocytic Macrophages
    TONI NAGY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Salmonella enterica subspecies Typhimurium is a natural pathogen of mice that establishes persistent, systemic infection...
  36. Host Pathways that Enable /Salmonella/ Replication Within Hemophagocytic Macropha
    CORRELLA DETWEILER; Fiscal Year: 2013
    ..b>Salmonella enterica, a species of gram-negative bacteria that includes the causative agent of human typhoid fever, resides ..
  37. Studies of a Bacterial Protein N-Lysine Acetyltransferase
    Sandy Thao; Fiscal Year: 2010
    ..We have an excellent model prokaryotic organism (Salmonella enterica) in which to perform the proposed work...
  38. Hemophagocytic Macrophages and Systemic Salmonella Infection
    CORRELLA DETWEILER; Fiscal Year: 2011
    ..b>Salmonella enterica, a species of gram-negative bacteria that includes the causative agent of human typhoid fever, resides ..
  39. Protective CD4+ T cells
    MARC KEVIN JENKINS; Fiscal Year: 2013
    ..endogenous CD4+ T cell response to a prototypical persistent phagosomal infection caused by ingestion of Salmonella enterica serovar Typhimuruim (ST) bacteria to gain insight into how protective CD4+ T cells are generated and ..
  40. THE SALMONELLA TYPHIMURIUM SIGMAE REGULON
    Ferric C Fang; Fiscal Year: 2013
    ..An alternative sigma factor called CE (SigmaE, RpoE) controls extracytoplasmic stress responses in Salmonella enterica sv. Typhimurium and other bacteria...
  41. Sulfur stress in Salmonella enterica
    Lawrence J Reitzer; Fiscal Year: 2010
    ..We propose to study cysteine-mediated stress in the model bacterium Salmonella enterica. To test this hypothesis, direct evidence for RSS by electron paramagnetic resonsance (EPR) spectrosopy ..
  42. SALMONELLA ANTIMICROBIAL PEPTIDE RESISTANCE
    John S Gunn; Fiscal Year: 2013
    ..Furthermore, we will investigate the PmrAB TCS and its function in the strict human pathogen Salmonella enterica serovar Typhi, where this important regulatory system has been poorly characterized...
  43. Virulence Factors of Salmonella
    ANDREAS J BAUMLER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Typhoid fever, caused by Salmonella enterica serotype Typhi (S. Typhi), is a major human disease responsible for 21.6 million illnesses and 216,000 deaths annually...
  44. Generating a library of antimicrobial R-type pyocins against enteric bacteria
    DEAN M SCHOLL; Fiscal Year: 2011
    ..agents targeting STEC serogroups O26, O45, O55, O91, O103, O111, O113, O118, O121, O145, O146, as well as Salmonella enterica serogroup D1, including serotypes enteriditis and typhi, and Vibrio cholera serotypes O1 and O139...
  45. Targeting bacterial phosphatases for novel anti-bacterial agents.
    Maurizio Pellecchia; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Yersinia pestis, Salmonella enterica, and Yersinia enterocolitica use a number of toxins to evade the immune system one of which is the protein tyrosine phosphatase YopH...
  46. Evaluation of Salmonella in Symptomatic and Asymptomatic Pets: Study for the Vet-
    Shelley Rankin; Fiscal Year: 2012
    ..The genus Salmonella consists of only two species, Salmonella enterica and Salmonella bongori. S...
  47. Physiological roles of regulated changes in membrane phospholipid composition
    John May; Fiscal Year: 2012
    ..affect activities that involve macromolecular interactions with phospholipids in the Gram-negative pathogen Salmonella enterica using genetic and biochemical approaches...
  48. Rabbit model to assess reactogenicity and immunogenicity of Salmonella vaccines
    Kenneth L Roland; Fiscal Year: 2013
    ..While strategies devised using attenuated Salmonella enterica serovar Typhimurium strains administered to mice has demonstrated this potential, when these same ..
  49. Virulence factors of Salmonella Typhi
    Jorge E Galan; Fiscal Year: 2012
    b>Salmonella enterica serovar Typhi (S. Typhi), the cause of typhoid fever in humans, continues to be a very significant health problem...
  50. Allelic variants of Salmonella fimbrial adhesins
    Dieter M Schifferli; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Salmonella enterica causes substantial morbidity and mortality worldwide. Foodborne salmonellosis is typically self-limiting and can generally be left untreated in healthy adults...
  51. Development of VesiVax Carbohydrate Conjugation Chemistry
    Gary Fujii; Fiscal Year: 2013
    ..Specifically, using the capsular polysaccharide Vi from Salmonella enterica (typhi) as our model carbohydrate antigen, we will couple Vi directly to VesiVax(R) CALVs containing a Toll-..
  52. COUPLING GENE EXPRESSION TO FLAGELLAR MORPHOGENESIS
    Kelly T Hughes; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Salmonella enterica causes significant disease in humans and animals. Like many gram-negative pathogens utilizes its flagellar organelles for motility...
  53. Genome Evolution in Pathogens: The roles of predator-prey interactions
    Jeffrey G Lawrence; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The pathogen Salmonella enterica is a common commensal inhabitant of mammalian, reptilian and avian intestinal environments...
  54. Development of anti-Salmonella Single-chain Abs as serum diagnostics
    Michael D Gunn; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Infection with Salmonella enterica is estimated to cause approximately 25 million illnesses and 200,000 to 250,000 deaths per year globally...
  55. CD4+ T cell-based immunity to gastrointestinal infection
    Ryan W Nelson; Fiscal Year: 2013
    ..supports the mission of the NIDDK by focusing on CD4+ T cell responses that are critical for controlling the gastrointestinal pathogen Salmonella enterica and could provide useful information on how to develop a more effective vaccine.
  56. Inhibition of T cells by Salmonella
    ADRIANUS WILHELMUS MARIA VAN DER VELDEN; Fiscal Year: 2013
    ..b>Salmonella enterica serovar Typhimurium (S...
  57. A Bioengineerable Self-adjuvating Nanoparticle for Antigen Delivery
    Shiladitya Dassarma; Fiscal Year: 2013
    ..We plan to test the effectiveness of HGVs as a vaccine vehicle against Salmonella enterica serovar Typhi, the causative agent of typhoid fever...
  58. Analysis of interacellular host defenses in Salmonella pathogenesis
    Andres Vazquez-Torres; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Salmonella enterica represents a considerable burden to human and animal health worldwide...
  59. MOLECULAR GENETIC ANALYSIS OF SALMONELLA CELL INVASION
    Jorge E Galan; Fiscal Year: 2013
    ..Through work supported by this Grant, we have been studying a T3SS from Salmonella enterica serovar Typhimurium (S. Typhimurium), encoded within its pathogenicty island 1 (SPI-1)...
  60. Iron Homeostasis in Salmonella-Host Interactions
    Ferric C Fang; Fiscal Year: 2010
    ..The specific aims of this research plan are to analyze the following aspects of the BaeSR system in Salmonella enterica: (1) Activation of BaeSR and characterization of the BaeSR regulon; (2) Identification of the novel ..
  61. HOST CELL SIGNALING PATHWAYS INDUCED BY SALMONELLA
    Jorge E Galan; Fiscal Year: 2013
    ..The pathogenicity of Salmonella enterica requires the activity of two type III protein secretion systems (T3SS) encoded within its pathogenicity ..
  62. Model-guided Identification of Synthetic Lethal Genes for Drug Target Development
    Bernhard O Palsson; Fiscal Year: 2013
    ..predictions would then be tested experimentally by constructing putative pairs in Escherichia coli and Salmonella enterica serovar Typhimurium...
  63. MUCOSAL DEFENSE MECHANISMS IN SUBSTANCE ABUSE
    David R Brown; Fiscal Year: 2010
    ..sites by detecting and eliminating enteric pathogens, including the human immunodeficiency virus (HIV) and Salmonella enterica. The intestinal mucosa contains, in addition to epithelial cells, an extensive nervous system capable of ..
  64. Live, oral, heat Stable S. typhi TY21a vaccine
    ERIC PATZER; Fiscal Year: 2006
    ..The rationale underlying this approach is to exploit the extensive safety record of the existing live, oral Salmonella enterica serovar Typhi strain Ty21 a vaccine...
  65. Structure of the multidrug efflux protein AcrA
    Partho Ghosh; Fiscal Year: 2006
    ..RND efflux systems are also encoded by Escherichia coli O157:H7, Salmonella enterica, Shigella flexneri, and Yersinia pestis. The most thoroughly characterized RND system is the E...
  66. YsrRS regulon of Y. enterocolitica
    VIRGINIA MILLER; Fiscal Year: 2009
    ..Thus, like Salmonella enterica, which has two TTSS that play different roles during the infectious process, the Ysc and Ysa TTSS may play ..
  67. New Sensitive Detection of Food and Water Borne Pathogens
    JAY GEORGE; Fiscal Year: 2005
    ..E. coli O157:H7, Listeria monocytogenes, Salmonella enterica and Cryptosporidium parvum food and water borne pathogens are accountable for 1 million infections annually ..
  68. Flagellar Phase Variation in Salmonella
    Kelly Hughes; Fiscal Year: 2005
    ..H.O. estimates). Salmonella enterica alternatively expresses one of two antigenically distinct flagellin proteins, FliC or FljB...
  69. Novel whole-animal screens for anti-microbials
    FREDERICK AUSUBEL; Fiscal Year: 2009
    ..The C. elegans screening methodology will also be extended to include the Gram negative pathogen Salmonella enterica and adapted to enable the identification of multi-drug resistant (MDR) pump inhibitors...
  70. Pathogenesis of S. Typhimurium bacteremia
    ANDREAS BAUMLER; Fiscal Year: 2009
    Non-typhoidal Salmonella serotypes are a leading cause of food-borne infections worldwide, with Salmonella enterica serotypes Typhimurium and Enteritidis being isolated most frequently...
  71. Salmonella vaccination with iron-regulated membrane proteins
    Lisa Herron Olson; Fiscal Year: 2007
    ..with three specific aims: In Aim 1, we will separate and identify the membrane proteins derived from Salmonella enterica serotype Newport grown under iron-limiting conditions; in Aim 2, we will test the separated fractions for ..
  72. Genome-wide Dissection of c. elegans Innate Immunity
    Man Wah Tan; Fiscal Year: 2006
    ..elegans by several human bacterial pathogens - Pseudomonas aeruginosa, Salmonella enterica and Enterococcus faecalis - as a model. C...
  73. HOST CELL SIGNALING PATHWAYS INDUCED BY SALMONELLA
    JORGE GALAN; Fiscal Year: 2002
    Salmonellosis continues to be a major world-wide health concern. Central to the pathogenicity of Salmonella enterica is its ability to engage host cells in an intimate two-way biochemical interaction...
  74. Salmonella's RpoE-Regulated Starvation-Stress Response
    Michael Spector; Fiscal Year: 2004
    ..Upon encountering such conditions, Salmonella enterica serovar Typhimurium (S...