salmonella

Summary

Summary: A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that utilizes citrate as a sole carbon source. It is pathogenic for humans, causing enteric fevers, gastroenteritis, and bacteremia. Food poisoning is the most common clinical manifestation. Organisms within this genus are separated on the basis of antigenic characteristics, sugar fermentation patterns, and bacteriophage susceptibility.

Top Publications

  1. ncbi Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet
    Efrain M Ribot
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Foodborne Pathog Dis 3:59-67. 2006
  2. pmc Foodborne illness acquired in the United States--major pathogens
    Elaine Scallan
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 17:7-15. 2011
  3. pmc Salmonella takes control: effector-driven manipulation of the host
    Emma J McGhie
    University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, UK
    Curr Opin Microbiol 12:117-24. 2009
  4. pmc Salmonella bongori provides insights into the evolution of the Salmonellae
    Maria Fookes
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS Pathog 7:e1002191. 2011
  5. ncbi Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole
    Cheryl L Birmingham
    Infection, Immunity, Injury and Repair Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 281:11374-83. 2006
  6. ncbi Robust Salmonella metabolism limits possibilities for new antimicrobials
    Daniel Becker
    Max Planck Institute for Infection Biology, Department of Molecular Biology, D 10117 Berlin, Germany
    Nature 440:303-7. 2006
  7. doi Global monitoring of Salmonella serovar distribution from the World Health Organization Global Foodborne Infections Network Country Data Bank: results of quality assured laboratories from 2001 to 2007
    Rene S Hendriksen
    National Food Institute, WHO Collaborating Centre for Antimicrobial Resistance in Foodborne Pathogens and Community Reference Laboratory for Antimicrobial Resistance, Technical University of Denmark, Copenhagen, Denmark
    Foodborne Pathog Dis 8:887-900. 2011
  8. pmc Genome wide evolutionary analyses reveal serotype specific patterns of positive selection in selected Salmonella serotypes
    Yesim Soyer
    Department of Food Science, Cornell University, 412 Stocking Hall, Ithaca, NY 14853, USA
    BMC Evol Biol 9:264. 2009
  9. pmc Genomic and proteomic characterization of the broad-host-range Salmonella phage PVP-SE1: creation of a new phage genus
    Silvio B Santos
    Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, Universidade do Minho, Campus de Gualtar, 4700 057 Braga, Portugal
    J Virol 85:11265-73. 2011
  10. pmc The ancestral SgrS RNA discriminates horizontally acquired Salmonella mRNAs through a single G-U wobble pair
    Kai Papenfort
    RNA Biology Group, Institute for Molecular Infection Biology, University of Wurzburg, D 97080 Wurzburg, Germany
    Proc Natl Acad Sci U S A 109:E757-64. 2012

Detail Information

Publications363 found, 100 shown here

  1. ncbi Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet
    Efrain M Ribot
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Foodborne Pathog Dis 3:59-67. 2006
    ..rapid pulsed-field gel electrophoresis (PFGE) protocols for the subtyping of Escherichia coli O157:H7, Salmonella serotypes, and Shigella species are described...
  2. pmc Foodborne illness acquired in the United States--major pathogens
    Elaine Scallan
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 17:7-15. 2011
    ..Most (58%) illnesses were caused by norovirus, followed by nontyphoidal Salmonella spp. (11%), Clostridium perfringens (10%), and Campylobacter spp. (9%)...
  3. pmc Salmonella takes control: effector-driven manipulation of the host
    Emma J McGhie
    University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, UK
    Curr Opin Microbiol 12:117-24. 2009
    b>Salmonella pathogenesis relies upon the delivery of over thirty specialised effector proteins into the host cell via two distinct type III secretion systems...
  4. pmc Salmonella bongori provides insights into the evolution of the Salmonellae
    Maria Fookes
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS Pathog 7:e1002191. 2011
    The genus Salmonella contains two species, S. bongori and S. enterica. Compared to the well-studied S. enterica there is a marked lack of information regarding the genetic makeup and diversity of S. bongori. S...
  5. ncbi Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole
    Cheryl L Birmingham
    Infection, Immunity, Injury and Repair Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 281:11374-83. 2006
    b>Salmonella enterica serovar Typhimurium (S. Typhimurium) is a facultative intracellular pathogen that causes disease in a variety of hosts. S...
  6. ncbi Robust Salmonella metabolism limits possibilities for new antimicrobials
    Daniel Becker
    Max Planck Institute for Infection Biology, Department of Molecular Biology, D 10117 Berlin, Germany
    Nature 440:303-7. 2006
    ..Here we have obtained in vivo information about over 700 Salmonella enterica enzymes from network analysis of mutant phenotypes, genome comparisons and Salmonella proteomes from ..
  7. doi Global monitoring of Salmonella serovar distribution from the World Health Organization Global Foodborne Infections Network Country Data Bank: results of quality assured laboratories from 2001 to 2007
    Rene S Hendriksen
    National Food Institute, WHO Collaborating Centre for Antimicrobial Resistance in Foodborne Pathogens and Community Reference Laboratory for Antimicrobial Resistance, Technical University of Denmark, Copenhagen, Denmark
    Foodborne Pathog Dis 8:887-900. 2011
    b>Salmonella enterica is commonly acquired from contaminated food and is an important cause of illness worldwide. Interventions are needed to control Salmonella; subtyping Salmonella by serotyping is useful for targeting such interventions...
  8. pmc Genome wide evolutionary analyses reveal serotype specific patterns of positive selection in selected Salmonella serotypes
    Yesim Soyer
    Department of Food Science, Cornell University, 412 Stocking Hall, Ithaca, NY 14853, USA
    BMC Evol Biol 9:264. 2009
    The bacterium Salmonella enterica includes a diversity of serotypes that cause disease in humans and different animal species...
  9. pmc Genomic and proteomic characterization of the broad-host-range Salmonella phage PVP-SE1: creation of a new phage genus
    Silvio B Santos
    Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, Universidade do Minho, Campus de Gualtar, 4700 057 Braga, Portugal
    J Virol 85:11265-73. 2011
    ..tool, even compared to the well-studied typing phage Felix 01, due to its broad lytic spectrum against different Salmonella strains...
  10. pmc The ancestral SgrS RNA discriminates horizontally acquired Salmonella mRNAs through a single G-U wobble pair
    Kai Papenfort
    RNA Biology Group, Institute for Molecular Infection Biology, University of Wurzburg, D 97080 Wurzburg, Germany
    Proc Natl Acad Sci U S A 109:E757-64. 2012
    ..We have discovered additional SgrS targets in Salmonella Typhimurium, a pathogen related to E...
  11. doi A rough guide to the non-coding RNA world of Salmonella
    Jörg Vogel
    RNA Biology Group, Max Planck Institute for Infection Biology, Chariteplatz 1, D 10117 Berlin, Germany
    Mol Microbiol 71:1-11. 2009
    b>Salmonella species are enterobacterial pathogens that have been exceptionally well investigated with respect to virulence mechanisms, microbial pathogenesis, genome evolution and many fundamental pathways of gene expression and metabolism...
  12. ncbi Interpolated variable order motifs for identification of horizontally acquired DNA: revisiting the Salmonella pathogenicity islands
    Georgios S Vernikos
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SA, UK
    Bioinformatics 22:2196-203. 2006
    ..g. in short sliding windows. Most of the current HGT prediction methods require pre-existing annotation, which may restrict their application on newly sequenced genomes...
  13. pmc The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella
    Shun Kageyama
    Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Biol Cell 22:2290-300. 2011
    b>Salmonella develops into resident bacteria in epithelial cells, and the autophagic machinery (Atg) is thought to play an important role in this process...
  14. ncbi Biofilm formation by Salmonella spp. and Listeria monocytogenes on plastic surface
    S Stepanovic
    Institute of Microbiology and Immunology, School of Medicine, Belgrade, Serbia
    Lett Appl Microbiol 38:428-32. 2004
    To investigate the biofilm formation by 122 Salmonella spp. and 48 Listeria monocytogenes strains on a plastic surface.
  15. pmc The generalized transducing Salmonella bacteriophage ES18: complete genome sequence and DNA packaging strategy
    Sherwood R Casjens
    Department of Pathology, University of Utah Medical School, Salt Lake City, UT 84132, USA
    J Bacteriol 187:1091-104. 2005
    ..bacteriophage ES18 has an icosahedral head and a long noncontractile tail, and it infects both rough and smooth Salmonella enterica strains...
  16. doi Analysis of the FoodNet case-control study of sporadic Salmonella serotype Enteritidis infections using persons infected with other Salmonella serotypes as the comparison group
    A C Voetsch
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Epidemiol Infect 137:408-16. 2009
    ..Data from the 1996-1997 FoodNet case-control study of laboratory-confirmed Salmonella serogroups B and D infection were used to estimate the effect of specific behaviours and foods on infection with ..
  17. pmc Genetic control of resistance to salmonellosis and to Salmonella carrier-state in fowl: a review
    Fanny Calenge
    INRA, UR Unité de Recherches Avicoles, Nouzilly, France
    Genet Sel Evol 42:11. 2010
    Salmonellosis is a frequent disease in poultry stocks, caused by several serotypes of the bacterial species Salmonella enterica and sometimes transmitted to humans through the consumption of contaminated meat or eggs...
  18. ncbi Salmonella pathogenicity islands encoding type III secretion systems
    I Hansen-Wester
    , Max von Pettenkofer-Institut, , Germany
    Microbes Infect 3:549-59. 2001
    b>Salmonella enterica harbours two Salmonella pathogenicity islands (SPIs) each encoding a type III secretion system for virulence proteins...
  19. pmc Life in the inflamed intestine, Salmonella style
    Renato L Santos
    Departamento de Clinica e Cirurgia Veterinarias, Escola de Veterinaria, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
    Trends Microbiol 17:498-506. 2009
    ..However, introduction of bacteria into the underlying tissue evokes acute inflammation. Non-typhoidal Salmonella serotypes (NTS) elicit this stereotypic host response by actively penetrating the intestinal epithelium and ..
  20. doi Enteric Salmonella or Campylobacter infections and the risk of inflammatory bowel disease
    Tine Jess
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen S, Denmark
    Gut 60:318-24. 2011
    ..of this study was to analyse incidence rates of Crohn's disease and ulcerative colitis among patients with Salmonella- or Campylobacter-positive and negative stool tests and to study the incidence of positive and negative stool ..
  21. ncbi Responses to the soluble flagellar protein FliC are Th2, while those to FliC on Salmonella are Th1
    Adam F Cunningham
    MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK
    Eur J Immunol 34:2986-95. 2004
    ..Conversely, when FliC is presented in its native context surface-bound on live, flagellated Salmonella, switching is predominantly to IgG2a (IgG2c in C57BL/6 mice), reflecting Th1 activity...
  22. pmc Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways
    Nicholas R Thomson
    The Pathogen Sequencing Unit, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    Genome Res 18:1624-37. 2008
    We have determined the complete genome sequences of a host-promiscuous Salmonella enterica serovar Enteritidis PT4 isolate P125109 and a chicken-restricted Salmonella enterica serovar Gallinarum isolate 287/91...
  23. pmc Food-related illness and death in the United States
    P S Mead
    Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 5:607-25. 1999
    ..Three pathogens, Salmonella, Listeria, and Toxoplasma, are responsible for 1,500 deaths each year, more than 75% of those caused by known ..
  24. pmc Induction of Salmonella pathogenicity island 1 under different growth conditions can affect Salmonella-host cell interactions in vitro
    J Antonio Ibarra
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Microbiology 156:1120-33. 2010
    b>Salmonella invade non-phagocytic cells by inducing massive actin rearrangements, resulting in membrane ruffle formation and phagocytosis of the bacteria...
  25. pmc The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway
    Marija Cemma
    Cell Biology Program, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Autophagy 7:341-5. 2011
    ..studies show that two adaptor proteins, p62 and NDP52, are required for autophagy of the bacterial pathogen Salmonella enterica serovar Typhimurium (S. typhimurium)...
  26. pmc Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis and pathogenic convergence with Salmonella typhi
    Wei Qiao Liu
    Genomics Research Center, Harbin Medical University, Harbin, China
    PLoS ONE 4:e4510. 2009
    Although over 1400 Salmonella serovars cause usually self-limited gastroenteritis in humans, a few, e.g., Salmonella typhi and S. paratyphi C, cause typhoid, a potentially fatal systemic infection...
  27. ncbi The Ames Salmonella/microsome mutagenicity assay
    K Mortelmans
    Molecular and Genetic Toxicology Program, SRI International, Menlo Park, CA 94025 3493, USA
    Mutat Res 455:29-60. 2000
    The Ames Salmonella/microsome mutagenicity assay (Salmonella test; Ames test) is a short-term bacterial reverse mutation assay specifically designed to detect a wide range of chemical substances that can produce genetic damage that leads ..
  28. pmc The small, slow and specialized CRISPR and anti-CRISPR of Escherichia and Salmonella
    Marie Touchon
    Département Génomes et Génétique, Institut Pasteur, Microbial Evolutionary Genomics, Paris, France
    PLoS ONE 5:e11126. 2010
    ..Here, we analyze the CRISPR loci of 51 complete genomes of Escherichia and Salmonella. CRISPR are in two pairs of loci in Escherichia, one single pair in Salmonella, each pair showing a similar ..
  29. ncbi Nontyphoidal salmonellosis
    E L Hohmann
    Infectious Diseases Division, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 32:263-9. 2001
    Nontyphoidal Salmonella are important foodborne pathogens that cause gastroenteritis, bacteremia, and subsequent focal infection...
  30. pmc Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes
    Carlos J Blondel
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago, Chile
    BMC Genomics 10:354. 2009
    ..According to these studies, Salmonella harbors a unique T6SS encoded in the Salmonella Pathogenicity Island 6 (SPI-6)...
  31. pmc Molecular phylogeny of the salmonellae: relationships among Salmonella species and subspecies determined from four housekeeping genes and evidence of lateral gene transfer events
    J R McQuiston
    Program in Population Biology, Ecology and Evolution, Emory University, Atlanta, GA 30322, USA
    J Bacteriol 190:7060-7. 2008
    The salmonellae are a diverse group of bacteria within the family Enterobacteriaceae that includes two species, Salmonella enterica and Salmonella bongori...
  32. ncbi The rapid detection of Salmonella from food samples by loop-mediated isothermal amplification (LAMP)
    Shigeko Ueda
    Laboratory of Hygiene, Kagawa Nutrition University, 3 9 21, Chiyoda, Sakado shi, Saitama 350 0214, Japan
    Biocontrol Sci 14:73-6. 2009
    Loop-mediated isothermal amplification (LAMP) assay was applied to the detection of Salmonella in food and human materials. It was possible for the assay to detect Salmonella within 60 min...
  33. pmc Antimicrobial resistance in invasive non-typhoid Salmonella from the Democratic Republic of the Congo: emergence of decreased fluoroquinolone susceptibility and extended-spectrum beta lactamases
    Octavie Lunguya
    National Institute for Biomedical Research, Kinshasa, Democratic Republic of the Congo
    PLoS Negl Trop Dis 7:e2103. 2013
    ..chloramphenicol and trimethoprim/sulphamethoxazole or multidrug resistance (MDR) is common in non typhoid Salmonella (NTS)...
  34. doi Salmonella T3SSs: successful mission of the secret(ion) agents
    Thomas P Moest
    Aix Marseille Universite, CIML, 13288 Marseille, France
    Curr Opin Microbiol 16:38-44. 2013
    Bacteria of the genus Salmonella express nanosyringe-like organelles called type three secretion systems (T3SSs). These systems promote the secretion of bacterial compounds and their translocation into host cells...
  35. ncbi Salmonella, the host and disease: a brief review
    Bryan Coburn
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    Immunol Cell Biol 85:112-8. 2007
    b>Salmonella species cause substantial morbidity, mortality and burden of disease globally. Infections with Salmonella species cause multiple clinical syndromes...
  36. doi The global burden of nontyphoidal Salmonella gastroenteritis
    Shannon E Majowicz
    Center for Food borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, Ontario, Canada
    Clin Infect Dis 50:882-9. 2010
    To estimate the global burden of nontyphoidal Salmonella gastroenteritis, we synthesized existing data from laboratory-based surveillance and special studies, with a hierarchical preference to (1) prospective population-based studies, (2) ..
  37. pmc A scalable method for O-antigen purification applied to various Salmonella serovars
    F Micoli
    Novartis Vaccines Institute for Global Health, 53100 Siena, Italy
    Anal Biochem 434:136-45. 2013
    ..Here, we describe a simplified methodology for extraction and purification of the O-antigen core portion of Salmonella lipopolysaccharide, suitable for large-scale production...
  38. ncbi Monocyte recruitment, activation, and function in the gut-associated lymphoid tissue during oral Salmonella infection
    Anna Rydström
    Department of Microbiology and Immunology, Goteborg University, Goteborg, Sweden
    J Immunol 178:5789-801. 2007
    ..and function of monocytes recruited to Peyer's patches (PP) and mesenteric lymph nodes (MLN) after oral Salmonella infection of mice...
  39. pmc Turning self-destructing Salmonella into a universal DNA vaccine delivery platform
    Wei Kong
    Center for Infectious Diseases and Vaccinology at the Biodesign Institute, and School of Life Sciences, Arizona State University, Tempe, AZ 85287 5401, USA
    Proc Natl Acad Sci U S A 109:19414-9. 2012
    We previously developed a biological containment system using recombinant Salmonella Typhimurium strains that are attenuated yet capable of synthesizing protective antigens...
  40. ncbi How Salmonella became a pathogen
    E A Groisman
    Dept of Molecular Microbiology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Trends Microbiol 5:343-9. 1997
    ..In contrast, the facultative intracellular lifestyle of Salmonella demands a large number of genes distributed around the chromosome...
  41. pmc Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms
    Susan L Fink
    Molecular and Cellular Biology Program, Departments of Microbiology and Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:4312-7. 2008
    Caspase-1 cleaves the inactive IL-1beta and IL-18 precursors into active inflammatory cytokines. In Salmonella-infected macrophages, caspase-1 also mediates a pathway of proinflammatory programmed cell death termed "pyroptosis...
  42. pmc Biofilm formation and interaction with the surfaces of gallstones by Salmonella spp
    A M Prouty
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Infect Immun 70:2640-9. 2002
    ..gallstones are more likely to become typhoid carriers, and antibiotic treatments are often ineffectual against Salmonella enterica serovar Typhi in carriers with gallstones. Therefore, we hypothesized that Salmonella spp...
  43. ncbi Human health consequences of antimicrobial drug-resistant Salmonella and other foodborne pathogens
    Kåre Mølbak
    Department of Epidemiology, Statens Serum Institut, Copenhagen, Denmark
    Clin Infect Dis 41:1613-20. 2005
    ..are several clinical and public health consequences associated with antimicrobial drug resistance in non-Typhi Salmonella species and other foodborne pathogens...
  44. doi Salmonellosis outcomes differ substantially by serotype
    Timothy F Jones
    Communicable and Environmental Disease Services, Tennessee Department of Health, 1st Floor, Cordell Hull Bldg, 425 5th Ave N, Nashville, TN 37243, USA
    J Infect Dis 198:109-14. 2008
    Most human infections are caused by closely related serotypes within 1 species of Salmonella. Few data are available on differences in severity of disease among common serotypes.
  45. pmc Novel cancer vaccine based on genes of Salmonella pathogenicity island 2
    Guosheng Xiong
    Division of Hematology Oncology, Department of Pediatrics, University of Southern California Keck School of Medicine and The Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, CA, USA
    Int J Cancer 126:2622-34. 2010
    ..In this study, we used genes of Salmonella pathogenicity island 2 (SPI2) to construct a novel cancer vaccine in which a TAA, survivin, was fused to SseF ..
  46. doi Evaluation of safety and protection efficacy on cpxR and lon deleted mutant of Salmonella Gallinarum as a live vaccine candidate for fowl typhoid
    Kiku Matsuda
    College of Veterinary Medicine and Bio Safety Research Institute, Chonbuk National University, Jeonju 561 756, Republic of Korea
    Vaccine 29:668-74. 2011
    We evaluated a recently developed live fowl typhoid (FT) vaccine candidate, JOL916, the cpxR/lon mutant of Salmonella Gallinarum (SG), for safety and protection efficacy in 5-week-old layer chickens...
  47. pmc SigmaE-dependent small RNAs of Salmonella respond to membrane stress by accelerating global omp mRNA decay
    Kai Papenfort
    Max Planck Institute for Infection Biology, Chariteplatz 1, 10117 Berlin, Germany
    Mol Microbiol 62:1674-88. 2006
    ..We report that in Salmonella the ESR relies upon two highly conserved, sigmaE-controlled small non-coding RNAs, RybB and MicA...
  48. pmc Taming the elephant: Salmonella biology, pathogenesis, and prevention
    Helene L Andrews-Polymenis
    Department of Microbiology, Box 357242, University of Washington School of Medicine, Seattle, WA 98195 7242, USA
    Infect Immun 78:2356-69. 2010
    b>Salmonella infections continue to cause substantial morbidity and mortality throughout the world. However, recent discoveries and new paradigms promise to lead to novel strategies to diagnose, treat, and prevent Salmonella infections...
  49. pmc Multiplex, bead-based suspension array for molecular determination of common Salmonella serogroups
    Collette Fitzgerald
    Enteric Diseases Laboratory Preparedness Branch, Division of Foodborne, Bacterial and Mycotic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Clin Microbiol 45:3323-34. 2007
    We report the development and evaluation of a Salmonella O-group-specific Bio-Plex assay to detect the six most common serogroups in the United States (B, C(1), C(2), D, E, and O13) plus serotype Paratyphi A...
  50. pmc Characterization of Salmonella occurring at high prevalence in a population of the land iguana Conolophus subcristatus in Galápagos Islands, Ecuador
    Alessia Franco
    Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana, Rome, Italy
    PLoS ONE 6:e23147. 2011
    The aim of the study was to elucidate the association between the zoonotic pathogen Salmonella and a population of land iguana, Colonophus subcristatus, endemic to Galápagos Islands in Ecuador...
  51. ncbi Salmonella: immune responses and vaccines
    P Mastroeni
    Centre for Veterinary Science, University of Cambridge, Madingley Road, Cambridge, CB3 OES, UK
    Vet J 161:132-64. 2001
    b>Salmonella infections are a serious medical and veterinary problem world-wide and cause concern in the food industry. Vaccination is an effective tool for the prevention of Salmonella infections...
  52. ncbi Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments
    Katie L Hopkins
    Antimicrobial Resistance and Molecular Epidemiology Unit, Laboratory of Enteric Pathogens, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5HT, UK
    Int J Antimicrob Agents 25:358-73. 2005
    ....
  53. doi SKIP, the host target of the Salmonella virulence factor SifA, promotes kinesin-1-dependent vacuolar membrane exchanges
    Audrey Dumont
    Centre d immunologie de Marseille Luminy, CNRS UMR 6102, INSERM U631, Universite de la Mediterranee, Parc Scientifique de Luminy, Case 906 13288 Marseille Cedex 9, France
    Traffic 11:899-911. 2010
    In Salmonella-infected cells, the bacterial effector SifA forms a functional complex with the eukaryotic protein SKIP (SifA and kinesin-interacting protein)...
  54. pmc Role of nonhost environments in the lifestyles of Salmonella and Escherichia coli
    Mollie D Winfield
    Howard Hughes Medical Institute, Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid, St Louis, Missouri 63110, USA
    Appl Environ Microbiol 69:3687-94. 2003
  55. doi The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen's virulence factors, and the host's mucosal immune response
    Patrick Kaiser
    Institute of Microbiology, D BIOL, ETH Zurich, Zurich, Switzerland
    Immunol Rev 245:56-83. 2012
    ..To study these mechanisms, the streptomycin mouse model for Salmonella diarrhea is of great value. Here, we review how S...
  56. pmc SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase
    F A Norris
    Division of Hematology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO, 63110, USA
    Proc Natl Acad Sci U S A 95:14057-9. 1998
    ..Here, we report that SopB, a protein secreted by Salmonella dublin, has sequence homology to mammalian inositol polyphosphate 4-phosphatases and that recombinant SopB has ..
  57. ncbi Interactions among components of the Salmonella flagellar export apparatus and its substrates
    T Minamino
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 8114, USA
    Mol Microbiol 35:1052-64. 2000
    ....
  58. doi Fresh fruit and vegetables as vehicles for the transmission of human pathogens
    Cedric N Berger
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK
    Environ Microbiol 12:2385-97. 2010
    ..Similarly, while infections with Salmonella have mainly been linked to consumption of foods of animal origin, many outbreaks have been traced to ..
  59. doi Salmonella-induced tubular networks
    Nina Schroeder
    Institute of Molecular Biology, Academia Sinica, Academia Rd 128 Sec 2, Nankang, Taipei 115, Taiwan, ROC
    Trends Microbiol 19:268-77. 2011
    b>Salmonella virulence relies on its capacity to replicate inside various cell types in a membrane-bound compartment, the Salmonella-containing vacuole (SCV)...
  60. pmc Caught at its own game: regulatory small RNA inactivated by an inducible transcript mimicking its target
    Nara Figueroa-Bossi
    Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique CNRS, Gif sur Yvette 91198, France
    Genes Dev 23:2004-15. 2009
    ..Here we show that induction of a Salmonella gene relies on the conversion of a small RNA from effector to regulatory target...
  61. doi Invasive non-typhoid salmonellae establish systemic intracellular infection in HIV-infected adults: an emerging disease pathogenesis
    Melita A Gordon
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Liverpool, UK
    Clin Infect Dis 50:953-62. 2010
    ..The importance of intracellular NTS infection in HIV is unknown...
  62. pmc Salmonella type III secretion effector SlrP is an E3 ubiquitin ligase for mammalian thioredoxin
    Joaquín Bernal-Bayard
    Departamento de Genetica, Facultad de Biologia, Universidad de Sevilla, 41080 Sevilla, Spain
    J Biol Chem 284:27587-95. 2009
    b>Salmonella enterica encodes two virulence-related type III secretion systems in Salmonella pathogenicity islands 1 and 2, respectively...
  63. ncbi Pathogenesis of enteric Salmonella infections
    Guntram A Grassl
    Michael Smith Laboratories, Canada
    Curr Opin Gastroenterol 24:22-6. 2008
    Gastrointestinal disease caused by Salmonella species leads to significant morbidity and mortality worldwide. The use of various animal models has greatly advanced understanding of Salmonella pathogenesis at intestinal and systemic sites...
  64. doi Molecular mechanisms of Salmonella virulence and host resistance
    Yanet Valdez
    Department of Microbiology and Immunology, Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    Curr Top Microbiol Immunol 337:93-127. 2009
    b>Salmonella species can cause typhoid fever and gastroenteritis in humans and pose a global threat to human health...
  65. pmc Components of the Salmonella flagellar export apparatus and classification of export substrates
    T Minamino
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    J Bacteriol 181:1388-94. 1999
    ....
  66. pmc New technologies in developing recombinant attenuated Salmonella vaccine vectors
    Shifeng Wang
    Center for Infectious Diseases and Vaccinology, The Biodesign Institute and School of Life Sciences, Arizona State University, Tempe, AZ 85287 5401, USA
    Microb Pathog 58:17-28. 2013
    Recombinant attenuated Salmonella vaccine (RASV) vectors producing recombinant gene-encoded protective antigens should have special traits...
  67. pmc Transmission of multiple resistant Salmonella Concord from internationally adopted children to their adoptive families and social environment: proposition of guidelines
    R Vanhoof
    National Reference Centre for Salmonella and Shigella, Bacterial Diseases Division, Communicable and Infectious Diseases, Scientific Institute of Public Health, 14 Wytsmanstreet, 1050, Brussels, Belgium
    Eur J Clin Microbiol Infect Dis 31:491-7. 2012
    Since 2004, an increasing number of multidrug-resistant Salmonella serovar Concord infections have been isolated in Belgium among children adopted from Ethiopia. The patients or their family were interviewed and the isolates were subtyped...
  68. ncbi Further evaluation of a multiplex PCR for differentiation of Salmonella paratyphi A from other salmonellae
    Cindy Shuan Ju Teh
    Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    Jpn J Infect Dis 61:313-4. 2008
    b>Salmonella enterica serovar Paratyphi A is a causative agent of paratyphoid fever. The clinical syndrome caused by paratyphoid fever overlaps with other febrile illnesses and cannot be distinguished from typhoid fever...
  69. doi Mechanism of copper surface toxicity in Escherichia coli O157:H7 and Salmonella involves immediate membrane depolarization followed by slower rate of DNA destruction which differs from that observed for Gram-positive bacteria
    S L Warnes
    Environmental Healthcare Unit, University of Southampton, Highfield, Southampton, UK
    Environ Microbiol 14:1730-43. 2012
    ..Similar results were obtained for Salmonella species but partial quenching by d-mannitol suggests radicals other than hydroxyl may be involved...
  70. doi Emergence of multidrug-resistant salmonella concord infections in Europe and the United States in children adopted from Ethiopia, 2003-2007
    Rene S Hendriksen
    WHO Collaborating Centre for Antimicrobial Resistance in Foodborne Pathogens and EU Community Reference Laboratory for Antimicrobial Resistance, National Food Institute, Technical University of Denmark, Copenhagen V, Denmark
    Pediatr Infect Dis J 28:814-8. 2009
    Multidrug-resistant Salmonella serovar Concord infections have been reported from children adopted from Ethiopia...
  71. doi Social networks and the spread of Salmonella in a sleepy lizard population
    C M Bull
    School of Biological Sciences, Flinders University, Adelaide, South Australia 5001, Australia
    Mol Ecol 21:4386-92. 2012
    ..We found multiple genetic strains of the enteric bacterium Salmonella enterica within a population of Australian sleepy lizards (Tiliqua rugosa), and we found that pairs of lizards ..
  72. pmc Infections associated with eating seed sprouts: an international concern
    P J Taormina
    Center for Food Safety and Quality Enhancement, University of Georgia, Griffin, Georgia 30223 1797, USA
    Emerg Infect Dis 5:626-34. 1999
    Recent outbreaks of Salmonella and Escherichia coli O157:H7 infections associated with raw seed sprouts have occurred in several countries...
  73. pmc Web-based surveillance and global Salmonella distribution, 2000-2002
    Eleni Galanis
    Danish Institute for Food and Veterinary Research, Søborg, Denmark
    Emerg Infect Dis 12:381-8. 2006
    ..WHO Global Salm-Surv members annually report the 15 most frequently isolated Salmonella serotypes to a Web-based country databank...
  74. ncbi Transfer of the Salmonella type III effector sopE between unrelated phage families
    S Mirold
    Max von Pettenkofer Institut, Pettenkoferstr 9a, 80336 Munchen, Germany
    J Mol Biol 312:7-16. 2001
    b>Salmonella spp. are pathogenic enterobacteria that employ type III secretion systems to translocate effector proteins and modulate responses of host cells...
  75. ncbi Enumeration of Salmonella and Escherichia coli O157:H7 in ground beef, cattle carcass, hide and faecal samples using direct plating methods
    D M Brichta-Harhay
    U S Department of Agriculture, Agricultural Research Service, Roman L Hruska U S Meat Animal Research Center, Clay Center, NE 68933 0166, USA
    J Appl Microbiol 103:1657-68. 2007
    To develop and validate high throughput methods for the direct enumeration of viable and culturable Salmonella and Escherichia coli O157:H7 in ground beef, carcass, hide and faecal (GCHF) samples from cattle.
  76. pmc Evaluation of a Salmonella vectored vaccine expressing Mycobacterium avium subsp. paratuberculosis antigens against challenge in a goat model
    Syed M Faisal
    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    PLoS ONE 8:e70171. 2013
    ..To develop a cost effective vaccine, in a previous study we constructed an attenuated Salmonella strain that expressed a fusion product made up of partial fragments of MAP antigens (Ag85A, Ag85B and SOD) that ..
  77. doi Salmonella, a cross-kingdom pathogen infecting humans and plants
    Casandra Hernández-Reyes
    Institute for Phytopathology and Applied Zoology IPAZ, Research Center for BioSystems, Land Use and Nutrition, Justus Liebig University Giessen, Giessen, Germany
    FEMS Microbiol Lett 343:1-7. 2013
    Infections with non-typhoidal Salmonella strains are constant and are a non-negligible threat to the human population. In the last two decades, salmonellosis outbreaks have increasingly been associated with infected fruits and vegetables...
  78. doi Salmonella interactions with plants and their associated microbiota
    Maria T Brandl
    U S Department of Agriculture, Albany, CA, USA
    Phytopathology 103:316-25. 2013
    ..Enteric disease caused by nontyphoidal Salmonella is a major public health burden, with the number of cases of illness linked to fresh produce, spices, and nuts ..
  79. doi Plants as alternative hosts for Salmonella
    Adam Schikora
    Institute for Plant Pathology and Applied Zoology, Research Centre for BioSystems, Land Use and Nutrition, JL University Giessen, Heinrich Buff Ring 26 32, 35392 Giessen, Germany
    Trends Plant Sci 17:245-9. 2012
    Recent findings show that many human pathogenic bacteria can use multiple host organisms. For example, Salmonella Typhimurium can use plants as alternative hosts to humans and other animals...
  80. ncbi Evolution of Salmonella O antigen variation by interspecific gene transfer on a large scale
    P Reeves
    Microbiology Department, University of Sydney, NSW, Australia
    Trends Genet 9:17-22. 1993
    The O antigen is a bacterial surface polysaccharide made up of repeats of a short oligosaccharide. There are about 60 forms of O antigen in Salmonella, and genetic analysis indicates that these were acquired by interspecific gene transfer.
  81. doi Salmonella infections associated with international travel: a Foodborne Diseases Active Surveillance Network (FoodNet) study
    Laura R Johnson
    Emory University School of Medicine and Rollins School of Public Health, Atlanta, Georgia, USA
    Foodborne Pathog Dis 8:1031-7. 2011
    b>Salmonella species cause an estimated 1.2 million infections per year in the United States, making it one of the most commonly reported enteric pathogens...
  82. pmc Enteric pathogens associated with childhood diarrhea in Tripoli-Libya
    Amal Rahouma
    Departments of Microbiology and Immunology, Faculty of Medicine, Alfateh University, Tripoli, Libya
    Am J Trop Med Hyg 84:886-91. 2011
    ..5%, 13.4%, and 11.2%, respectively); Salmonella, adenovirus, and Aeromonas were detected less frequently (7.9%, 7.1%, and 4.2%)...
  83. pmc Hospitalization and antimicrobial resistance in Salmonella outbreaks, 1984-2002
    Jay K Varma
    Centers for Disease Control and Prevention, Atlanta, GA, USA
    Emerg Infect Dis 11:943-6. 2005
    Few studies have evaluated the health consequences of antimicrobial-resistant Salmonella strains associated with outbreaks...
  84. pmc Salmonellosis in Lagos, Nigeria: incidence of Plasmodium falciparum-associated co-infection, patterns of antimicrobial resistance, and emergence of reduced susceptibility to fluoroquinolones
    Kabir O Akinyemi
    Department of Microbiology, Lagos State University, Ojo PMB 1087, Apapa, Lagos, Nigeria
    J Health Popul Nutr 25:351-8. 2007
    The present study was undertaken to examine the status of antimicrobial resistance in Salmonella-associated diseases, by verifying possible emergence of reduced susceptibility to fluoroquinolones in Salmonella isolates and determining the ..
  85. doi Investigation of the role of the BAM complex and SurA chaperone in outer-membrane protein biogenesis and type III secretion system expression in Salmonella
    Yann Fardini
    INRA, UR1282 Infectiologie Animale et Santé Publique, F 37380 Nouzilly, France
    Microbiology 155:1613-22. 2009
    ..e. BamB, BamC, BamD and BamE), and the periplasmic chaperones SurA and DegP, in these two phenotypes in Salmonella. Analysis of the corresponding deletion mutants showed that, as previously described with the DeltabamB mutant, ..
  86. doi Changes in causes of acute gastroenteritis in the United Kingdom over 15 years: microbiologic findings from 2 prospective, population-based studies of infectious intestinal disease
    Clarence C Tam
    Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK
    Clin Infect Dis 54:1275-86. 2012
    ..We examined changes in etiology and diagnostic yield of IID cases over 15 years...
  87. ncbi Multidrug resistant Salmonella Concord is a major cause of salmonellosis in children in Ethiopia
    Getenet Beyene
    Department of Medical Microbiology, Immunology and Parasitology, Jimma, University, Ethiopia
    J Infect Dev Ctries 5:23-33. 2011
    S. Concord in Ethiopia. The objective of this study was to determine the aetiology of febrile and diarrhoeic illness in Ethiopian children focussing on Salmonella.
  88. ncbi The use of organic acids to combat Salmonella in poultry: a mechanistic explanation of the efficacy
    F Van Immerseel
    Ghent University, Faculty of Veterinary Medicine, Research Group Veterinary Public Health and Zoonoses, Department of Pathology, Bacteriology and Avian Diseases, Salisburylaan 133, B 9820, Merelbeke, Belgium
    Avian Pathol 35:182-8. 2006
    b>Salmonella is a human pathogen that is commonly found in poultry products. It is possible to decrease chicken carcass and egg contaminations by adding organic acids to the feed or drinking water at appropriate times...
  89. ncbi An enhanced discriminatory pulsed-field gel electrophoresis scheme for subtyping Salmonella serotypes Heidelberg, Kentucky, SaintPaul, and Hadar
    Meili Xi
    College of Food Science and Engineering, Northwest A and F University, Shaanxi, China
    J Food Prot 71:2067-72. 2008
    ..restriction enzymes (SpeI, PacI, SfiI, and NotI), in addition to XbaI and BlnI, were used in PFGE typing of 33 Salmonella Heidelberg, 27 Salmonella Kentucky, 27 Salmonella SaintPaul, and 27 Salmonella Hadar isolates that were ..
  90. doi Wild boars as an important reservoir for foodborne pathogens
    Silke Wacheck
    Faculty of Veterinary Medicine, Institute of Food Hygiene and Technology, Ludwig Maximilians University, Munich, Germany
    Foodborne Pathog Dis 7:307-12. 2010
    ..The detection rate of Salmonella spp...
  91. pmc A fundamental regulatory mechanism operating through OmpR and DNA topology controls expression of Salmonella pathogenicity islands SPI-1 and SPI-2
    Andrew D S Cameron
    Department of Microbiology, Moyne Institute of Preventive Medicine, School of Genetics and Microbiology, Trinity College Dublin, Dublin, Ireland
    PLoS Genet 8:e1002615. 2012
    ..relaxation of DNA supercoiling strongly induces the well-studied pathogenicity gene ssrA (also called spiR) in Salmonella enterica, but neither the mechanism nor the proteins involved are known...
  92. ncbi Salmonella-mediated oral DNA vaccination using stabilized eukaryotic expression plasmids
    H Bauer
    Molecular Immunology, German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Gene Ther 12:364-72. 2005
    The use of Salmonella for the delivery of plasmid-encoded heterologous antigens to eukaryotic host cells has proven successful in experimental systems, but its general applicability is still hampered by a severe instability of ..
  93. ncbi Development of a complete ELISA using Salmonella lipopolysaccharides of various serogroups allowing to detect all infected pigs
    K Proux
    AFSSA Ploufragan, BP 53, Zoopole Beaucemaine, France
    Vet Res 31:481-90. 2000
    Although poultry is recognized as the major source of food-poisoning caused by Salmonella, pork also contributes to human infections...
  94. pmc Modulation of the stability of the Salmonella fourU-type RNA thermometer
    Jörg Rinnenthal
    Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe University, Max von Laue Strasse 7, D 60438 Frankfurt Main, Germany
    Nucleic Acids Res 39:8258-70. 2011
    ..Binding of the two Mg(2+) ions exhibits a positive cooperativity with a Hill coefficient of 1.47. Free energy values ΔG for Mg(2+) binding determined by NMR are in agreement with data determined from CD measurements...
  95. pmc Salmonella phage ST64B encodes a member of the SseK/NleB effector family
    Nat F Brown
    Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia
    PLoS ONE 6:e17824. 2011
    b>Salmonella enterica is a species of bacteria that is a major cause of enteritis across the globe, while certain serovars cause typhoid, a more serious disease associated with a significant mortality rate...
  96. pmc Physiology, pathogenicity and immunogenicity of lon and/or cpxR deleted mutants of Salmonella Gallinarum as vaccine candidates for fowl typhoid
    Kiku Matsuda
    College of Veterinary Medicine and Bio Safety Research Institute, Chonbuk National University, Jeonju, 561 756, Republic of Korea
    Vet Res 41:59. 2010
    To construct a novel live vaccine candidate for fowl typhoid (FT) caused by Salmonella Gallinarum (SG), the lon and cpxR genes that are related to host-pathogen interaction were deleted from a wild type SG using the allelic exchange ..
  97. pmc Regulation of phenotypic heterogeneity permits Salmonella evasion of the host caspase-1 inflammatory response
    Mary K Stewart
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 108:20742-7. 2011
    ..In culture, Salmonella Typhimurium populations are bistable for the expression of flagellin...
  98. doi Mucosal vaccination with a codon-optimized hemagglutinin gene expressed by attenuated Salmonella elicits a protective immune response in chickens against highly pathogenic avian influenza
    Karen A Liljebjelke
    Agricultural Research Service, USDA, Athens, GA 30605, USA
    Vaccine 28:4430-7. 2010
    The purpose of this study was to evaluate clinical protection from challenge conferred by two attenuated Salmonella enteria serovar typhimurium vaccine strains expressing the hemagglutinin (HA1) gene from a highly pathogenic avian ..
  99. pmc Kinetic characterization of Salmonella FliK-FlhB interactions demonstrates complexity of the Type III secretion substrate-specificity switch
    Daniel P Morris
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Biochemistry 49:6386-93. 2010
    ....
  100. pmc A substrate of the centisome 63 type III protein secretion system of Salmonella typhimurium is encoded by a cryptic bacteriophage
    W D Hardt
    Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, NY 11794 5222, USA
    Proc Natl Acad Sci U S A 95:2574-9. 1998
    b>Salmonella enterica has evolved a type III protein secretion system that allows these enteropathogens to translocate effector molecules directly into the host cell cytoplasm...
  101. pmc A PhoQ/P-regulated small RNA regulates sensitivity of Escherichia coli to antimicrobial peptides
    Kyung Moon
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Mol Microbiol 74:1314-30. 2009
    ..the PhoP response regulator is active under low Mg2+ concentrations and is an important virulence regulator in Salmonella; mgrR is also found in Salmonella species...

Research Grants74

  1. Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T Cells
    Craig T Morita; Fiscal Year: 2013
    ..We now propose to develop new vaccines for V32V42 T cell cancer immunotherapy by metabolic engineering Salmonella and Listeria bacteria to overproduce HMBPP...
  2. Integrated Microfluidic Platform for Point-of-Care Serodiagnostics
    Xiaowu Liang; Fiscal Year: 2013
    ..priority agents (Brucella melitensis, Francisella tularensis, Burkholderia pseudomallei, Coxiella burnetii, Salmonella enterica typhi, Rickettsia rickettsii, Orientia tsutsugamushi, Toxoplasma gondii, M...
  3. Mucosal Immunity, Vaccines and Microbiota Interplay in Humans and Animal
    Marcelo B Sztein; Fiscal Year: 2013
    ..efforts on in-depth studies of 3 major gram negative bacterial human pathogens including Helicobacter pylori, Salmonella enterica serovar Typhi and Shigella, each primarily affecting a distinct major segment of the Gl tract (i.e...
  4. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ..I, which has been implicated in DNA damage repair in several bacterial species, as well as in virulence of Salmonella typhimurium. Transcriptional linkage of polA.1 with perR raises the possibility that PolA...
  5. Fatty acid related regulation of enteric infectious disease
    FREDRICK JON KULL; Fiscal Year: 2012
    ..analysis has indicated that a number of pathogenic bacteria, including several types of Escherichia coli, Salmonella typhi, Salmonella typhimurium, Shigella flexneri, and Yersinia enterocolitica, contain A/X regulators with ..
  6. Recombinant Attenuated Salmonella Vaccines for Humans
    Roy Curtiss; Fiscal Year: 2012
    ..The numbers of annual deaths due to infections by Salmonella Typhi and S...
  7. Hospital - Based Surveillance of Acute Febrile Illness in Western Ghat Region of
    ARUNKUMAR GOVINDAKARNAVAR; Fiscal Year: 2013
    ..samples will be tested for a variety of etiologies associated with AFI such as, Bacterial pathogens (Leptospira, Salmonella, Brucella, Lyme borrelia, S. pneumoniae, H.influenzae, N. meningitidis, Shigella, Campylobacter etc...
  8. Salmonella Vaccines Against Bacterial Enteropathogens
    Roy Curtiss; Fiscal Year: 2013
    ..8 (WHO) to 2.2 (UNESCO) million are due to infections with enteric pathogens including Salmonella, Escherichia coli and Shigella sp., and other entero-pathogens such as Yersinia sp...
  9. Biochemistry and Function of a Novel Bacterial Photosensory Two-Component System
    MELISSA MARKS; Fiscal Year: 2010
    ..Health Organization, over 130,000 cases of cholera (Vibrio cholerae) and 17 million cases of Typhoid fever (Salmonella typhi) occur annually...
  10. Enhanced Membrane Systems for Supplying Quality Drinking Water
    Andrew Feiring; Fiscal Year: 2013
    ..A variety of bacteria such as Salmonella, Campylobacter and toxigenic E...
  11. OmpR and SsrB Regulation of Salmonella Virulence
    Linda J Kenney; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): PROJECT SUMMARY Salmonella infections are a major health problem worldwide. Salmonella causes disease by expressing genes that are located on pathogenicity islands...
  12. 5500 QTRAP
    John W Turk; Fiscal Year: 2010
    ..Wisconsin-Madison);(5) Molecular bases of antimicrobial resistance and virulence in pathogenic Salmonella gram-negative bacteria (Dr. Eduardo Groisman, WU, and Dr. Yixin Shi, Univ...
  13. MUCOSAL DEFENSE MECHANISMS IN SUBSTANCE ABUSE
    David R Brown; Fiscal Year: 2010
    ..sites by detecting and eliminating enteric pathogens, including the human immunodeficiency virus (HIV) and Salmonella enterica...
  14. Inhibitors of the Y. pestis cell surface plasminogen activator for biodefense
    Marjorie H Barnes; Fiscal Year: 2010
    ..Furthermore, homologous omptins are virulence factors in E. coli, Salmonella and Shigella, enhancing evasion of the host innate immune system and facilitating inter- and intracellular ..
  15. Intestinal Inflammation Induced by Pathogens
    Beth A McCormick; Fiscal Year: 2013
    ..event of massive transepithelial migration of PMNs occurs in the acute phase of gastroenteritis induced by Salmonella enterica serovar Typhimurium (salmonellosis)...
  16. Acquisition of a MALDI-TOF/TOF MS for Glycomic and Lipidomic Research
    Larry S Schlesinger; Fiscal Year: 2010
    ..tb) and other Mycobacterium spp infections within the human host;ii) Molecular mechanisms used by Salmonella and Francisella spp to survive within the human host;iii) Clinical research on dry eye disease in perimenopausal ..
  17. Transcriptional Regulation by a Deacetylase, CobB, in a Periodontopathogen
    DAVID J KOLODRUBETZ; Fiscal Year: 2013
    ..The bacterial Sir2 homologue is called CobB. In Salmonella enterica, this deacetylase has been shown to regulate the enzymatic activity of several enzymes in intermediary ..
  18. CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENTAL TOXICOLOGY PROGRAM
    CLARK ALGAIER; Fiscal Year: 2009
    ..Also under GenTox Testing program chemicals were shipped for salmonella testing...
  19. CT EIP Capacities ACA Grant
    TRACEY L WEEKS; Fiscal Year: 2011
    ..This person will be responsible for testing of specimens for organisms related to FoodNet activities (Salmonella, Shigella, E...
  20. Multiplex Serodiagnostic Protein Microarray
    PHILIP LOUIS FELGNER; Fiscal Year: 2012
    ..we will fabricate whole proteome microarrays for Coxiella burnetii, Rickettsia prowazekii, Brucella melitensis, Salmonella typhi, and non-homologous proteins from related strains of each agent...
  21. LIPID A MODIFICATION SYSTEMS IN GRAM-NEGATIVE BACTERIA
    Pei Zhou; Fiscal Year: 2012
    ..Bacteria of this kind, which include all strains of Escherichia coli, Salmonella, Pseudomonas, and Francisella, contain an outer membrane that makes them impermeable to certain dyes and ..
  22. Structures of RNA processing and Silencing Enzymes in Prokaryotes
    Hong Li; Fiscal Year: 2013
    ..Haemophilus influenzae, Helicobacter pylori, Neisseria meningitides, Vibrio vulnificus, Staphylococcus aureus, Salmonella Typhi and Clostridium tetani...
  23. A. L. lactis-based vaccine for children with broad spectrum for enteric pathogens
    Wendy L Picking; Fiscal Year: 2013
    ..of a broad-spectrum pediatric vaccine against Category B Biodefense food and water borne pathogens: Shigella, Salmonella and Yersinia enterocolitica...
  24. Regulation of Streptomyces differentiation and antibiotic production by SoxR
    Monica Chander; Fiscal Year: 2010
    ..SoxR has traditionally been known as the mediator of an oxidative stress response in Escherichia coli and Salmonella enterica, but this role may be restricted to enteric bacteria...
  25. Molecular mechanisms of pathogen recognition by the Nod-like receptor NLRC4
    Fayyaz S Sutterwala; Fiscal Year: 2012
    ..aeruginosa in vivo. In addition to Pseudomonas, other Gram-negative bacteria such as Salmonella, Legionella and Shigella have also been found to activate the NLRC4 inflammasome...
  26. Novel anti-toxin compounds against Yersinia infections
    Maurizio Pellecchia; Fiscal Year: 2010
    ..community outside the scope of the current application, supporting efforts on understanding how Yersinia pestis, Salmonella enterica, Francisella tularensis, Chlamydia psiticai, and Strep...
  27. Coordination of metabolism and virulence during infection
    Tony Romeo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Salmonella infections are a significant cause of morbidity and mortality in both developed and developing nations...
  28. Functional consequences of autophagy mutations in Crohn's disease.
    David L Boone; Fiscal Year: 2012
    ..Lastly, autophagy is required for defense or against intracellular pathogens including species of Mycobacterium, Salmonella, Listeria and many other microbes...
  29. Novel gene-silencing therapeutics for multidrug-resistant gram-negative pathogens
    DAVID ELIHU GREENBERG; Fiscal Year: 2013
    ..successfully to kill a variety of bacterial pathogens including the Gram-negative bacteria Escherichia coli, Salmonella typhimurium, Burkholderia cepacia complex and Acinetobacter baumannii...
  30. Functional genomics of human variation to Salmonella invasion
    DENNIS CHUN YONE KO; Fiscal Year: 2013
    ..how human genetic differences contribute to variation in infection by the bacteria that causes typhoid fever, Salmonella typhi. The first aim is to identify human genetic differences that modify invasion of S...
  31. Effects of apoptotic epithelial cell engulfment on mucosal inflammation
    Peter B Ernst; Fiscal Year: 2010
    ..In contrast, cells that undergo apoptosis when they carry an intracellular infection with Salmonella enterica serovar Typhimurium may act as a microbial "Trojan horse" that transports internalized bacteria into ..
  32. MECHANISMS OF SALMONELLA INVASION AND TRANSMIGRATION
    James E Casanova; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Salmonella infect their animal hosts by entering into and traversing the intestinal epithelial barrier...
  33. The Role of PtdIns-5-P in Cell Function and Signaling
    LUCIA RAMEH-PLANT; Fiscal Year: 2012
    ..cells, due to the activity of the bacterial virulence factors IpgD (from Shigella flexneri) and SigD/SopB (from Salmonella enterica), which are phosphatases that use PI-4,5-P2 as substrate...
  34. Multiplexed Detection of Food and Waterborne Pathogens
    Francis Barany; Fiscal Year: 2011
    ..PCR/LDR assays to identify Category B bacterial pathogens (Campylocbacter jejuni, Yersinia enterocolitica, Salmonella spp, Shigella spp, Diarrheagenic E. coli, Pathogenic Vibrio spp, and Listeria monocytogenes)...
  35. Induced Pluripotent Stem Cells from Swine: application to genetic modification
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2013
    ..LDLR deficiency and associated hypercholesterolemia are also postulated to protect against Salmonella infections...
  36. Modular Subunit Vaccine for Salmonella
    MARC KEVIN JENKINS; Fiscal Year: 2011
    b>Salmonella enterica serovar Typhi causes disease in millions of individuals who ingest contaminated food or water. Ingested S...
  37. Spin labeling of MsbA
    Candice S Klug; Fiscal Year: 2012
    ..transporter for lipid A that is found in the inner membranes of Gram-negative bacteria such as Escherichia coli, Salmonella typhimurium, and Vibrio cholerae...
  38. Regulation of Pore Formation by Type III Secretion System
    Gloria I Viboud; Fiscal Year: 2010
    ..Some of these organisms include important entropathogens such as Salmonella spp., Shigella spp., Yersinia enterocolitica, Y...
  39. Global Genomic and Proteomic Profiling of African Children with Typhoid Fever
    Stephen Obaro; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Typhoid fever is caused by Salmonella enteric serovar Typhi (S. typhi), a human specific pathogen...
  40. BIOSYNTHESIS AND FUNCTION OF LIPOPOLYSACCHARIDES
    Pei Zhou; Fiscal Year: 2013
    ..Bacteria of this kind, which include all strains of Escherichia coli, Salmonella, Pseudomonas, and Francisella, contain an outer membrane that makes them impermeable to certain dyes and ..
  41. Probing localiztion, interactions, and effector properties of Shigella lpaD
    NICHOLAS EUGENE DICKENSON; Fiscal Year: 2010
    ..S. flexneri along with numerous other important pathogens such as Yersinia pestis (plague), Salmonella (gastroenteritis), and Pseudomonas aeruginosa (lung infection) utilize the type III secretion system (TTSS) as a ..
  42. A novel Salmonella vaccine to protect against extra intestinal pathogenic E. coli
    Melha Mellata; Fiscal Year: 2011
    ..We have spent the last few years elucidating the virulence factors of ExPECs and Salmonella. We have constructed recombinant attenuated Salmonella vaccine vector systems for animals and humans that are ..
  43. Campylobacter jejuni outer membrane protein vaccine
    Stuart Thompson; Fiscal Year: 2009
    ..4 million cases of C. jejuni disease in the U.S. annually, with an incidence exceeding that of Salmonella and Shigella combined (5). C...
  44. Mechanistic Studies of Alkyl Hydroperoxide Reductase and Related Redox Proteins
    Leslie B Poole; Fiscal Year: 2013
    ..g. Salmonella typhimurium AhpC)...
  45. Optimization of novel pyranopyridine efflux pump inhibitors
    Son Truong Nguyen; Fiscal Year: 2013
    ..the antibacterial activity of FQ and beta-lactam antibiotics against Escherichia coli, Shigella flexneri, Salmonella enterica, Enterobacter cloacae, and Klebsiella pneumoniae by inhibiting the major efflux pump in these organisms ..
  46. RmpA, a unique virulence regulator in emerging Klebsiella pneumoniae
    Valley J Stewart; Fiscal Year: 2012
    ..extraintestinal infections are caused by specific strains of the closely-related species Escherichia, Shigella, Salmonella and Klebsiella...
  47. The Electrochemistry of Diheme Cytochrome c Peroxidases
    Sean J Elliott; Fiscal Year: 2010
    ..Further, our study of triheme CCPs will elucidate the CCP machinery which is unique to pathogens such as Salmonella enterica and Yersinia pestis, providing new insights into their biochemical pathways.
  48. GENETIC CONTROL OF NITRATE RESPIRATION IN E. COLI
    Valley J Stewart; Fiscal Year: 2010
    Enterobacteria such as Escherichia coli and Salmonella enterica are facultative aerobes, and when cultured in the absence of oxygen can use a variety of alternative respiratory oxidants...
  49. Microbial Invasion of the Intestine at the Cell Extrusion Zone of the Villus Tip
    Manuel R Amieva; Fiscal Year: 2012
    ..6% of deaths from enteric infection. Other important pathogens that invade the epithelium include rotavirus, Salmonella, Shigella, Yersinia, enteroinvasive E. coli, and Campylobacter...
  50. Pl3K Regulation of Microbicidal Pathways in Macrophages in Experimental Colitis
    Erin C Steinbach; Fiscal Year: 2013
    ..coli, enteroadherent NC101 E. coli, and pathogenic Salmonella typhimurium...
  51. The role of PhoP/PhoQ-regulated phospholipid alterations in Salmonella pathogenes
    ZACHARY DALEBROUX; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Salmonella enterica is a Gram-negative pathogen of worldwide importance causing a variety of diseases including typhoid fever, enterocolitis and bacteremia...
  52. Bacteria Based Agents for Therapy of AIDS Associated Infections
    Sangwei Lu; Fiscal Year: 2010
    ..The objective of this study is to develop Salmonella as a novel class of gene transfer vectors for targeted delivery of anti-HCMV RNase P ribozymes for blocking ..
  53. Structural and functional studies of autoinducer-2 processing proteins
    Stephen T Miller; Fiscal Year: 2012
    ..Many species of bacteria are known to carry the gene for LuxS, the AI-2 synthase, including pathogens such as Salmonella typhimurium, Bacillus anthracis, Yersinia pestis, and Vibrio cholerae [84]...
  54. The developing intestinal immune system in Yersinia enterocolitica infection
    REBECCA D ADKINS; Fiscal Year: 2010
    ..Bacteria (Y. enterocolitica and Salmonella) engineered to express only YopP will be applied to modulate inflammation in DSS-induced colitis in neonates...
  55. Design and mechanistic studies of mimics of antimicrobial peptides
    William F Degrado; Fiscal Year: 2012
    ..the activity of the peptides against a panel of Gram negative and positive bacteria including Escherichia coli, Salmonella enterica, Pseudomonas aeruginosa, and Staphylococcus aureus;4) measuring in vivo activity versus S. aureus and P...
  56. IDO-silencing Salmonella therapy for the treatment of primary and metastatic PDAC
    Don J Diamond; Fiscal Year: 2013
    ..ShIDO-ST is a novel Salmonella typhimurium (ST)-based therapy that expresses a small hairpin (sh)RNA to specifically silence tumor-derived IDO ..
  57. PHOP REGULON AND SALMONELLA VIRULENCE
    Samuel I Miller; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Salmonella are facultative intracellular pathogens which cause significant diseases in humans and animals...
  58. Bacterial effectors targeting the IKK/NF-kB pathway
    PHILIP ROSS HARDWIDGE; Fiscal Year: 2013
    ..coli (STEC) and related enteric pathogens (e.g. Salmonella, Shigella, Yersinia) are causing increasingly frequent outbreaks of food-borne diarrheal disease, thus ..
  59. A New Point of Use Decontamination Method for Fresh Produce
    ADRIAN J DENVIR; Fiscal Year: 2010
    ..in fruits and vegetables have been linked to several microbial species, including Escherichia coli O157:H7, Salmonella species, Listeria monocytogenes, Shigella species, Cyclospora cayetanensis, Hepatitis A virus, and Norwalk-like ..
  60. Recombinant Attenuated Bacterial Vaccines Against Biodefense Agents
    Roy Curtiss; Fiscal Year: 2013
    ..and provide data to secure IND licenses from FDA for Phase I clinical trials to test recombinant attenuated Salmonella Typhimurium, Paratyphi A and Typhi vaccines to prevent Salmonella-induced gastroenteritis, enteric fever and ..
  61. Impact of corn grind diameter and housing environment on performance and presence
    Kenneth Anderson; Fiscal Year: 2013
    ..in stomacher bags and processed at the Department of Poultry Science, for analysis for microbial analysis for Salmonella. Additionally, environmental microbial analysis will be conducted on samples collected from each experimental ..
  62. Silencing and Counter-Silencing of Salmonella Virulence Genes
    Ferric C Fang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pathogenic bacteria such as Salmonella enterica contain horizontally acquired DNA on plasmids or genomic islands that play a critically important role in host-pathogen interactions...
  63. Campylbacter jejuni flagellar regulation and synthesis
    David R Hendrixson; Fiscal Year: 2013
    ..According to the Centers for Disease Control, C. jejuni competes with Salmonella species as the leading cause of bacterial gastroenteritis in the United States. In contrast, C...
  64. S. typhimiurium Vaccine Against Bacterial Enteropathogens
    Roy Curtiss; Fiscal Year: 2007
    ..9 million annual deaths (1997) due to infectious diseases, about 2 million are the result of infections by Salmonella and other related bacterial enteropathogens including Escherichia coli and Shigella species, and less closely ..
  65. PEPTIDE BASED SALMONELLA VACCINE DELIVERY SYSTEM
    Lee Riley; Fiscal Year: 1999
    ..sequence will be used to identify an oral vaccine candidate to protect against bacteremia in a murine model of Salmonella enteritidis infection...
  66. 3rd ASM Conference on Salmonella
    Ferric Fang; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): We are requesting funds to provide support for the 3rd ASM Salmonella conference to be held from 5-9 October 2009 in Aix-en-Provence, France...
  67. SALMONELLA ANTIMICROBIAL PEPTIDE RESISTANCE
    John Gunn; Fiscal Year: 2002
    ..Non-typhoidal Salmonella infections are often associated with contaminated food, including frequent egg-related outbreaks of Salmonella ..
  68. Evaluation of Salmonella in Symptomatic and Asymptomatic Pets: Study for the Vet-
    Shelley Rankin; Fiscal Year: 2012
    ..The genus Salmonella consists of only two species, Salmonella enterica and Salmonella bongori. S...
  69. Evaluation of Salmonella in Symptomatic and Asymptomatic Pets
    Timothy S Frana; Fiscal Year: 2012
    Project Summary The objective of this study is to determine the prevalence and types of Salmonella in fecal samples from both symptomatic and asymptomatic animals brought to veterinary clinics...
  70. MOLECULAR PATHOGENESIS OF SALMONELLA TYPHIMURIUM
    JAMES SLAUCH; Fiscal Year: 1999
    ..The long-term objectives of this research are to understand, at the molecular level, the mechanisms by which Salmonella typhimurium circumvents the host immune system and causes disease...
  71. SPATIOTEMPORAL ANALYSES OF NEONATAL HOST RESPONSE
    Christopher Contag; Fiscal Year: 2002
    ..b>Salmonella typhimurium infections begin in the gastrointestinal (GI) tract, and following penetration of the epithelial ..
  72. CD4+ T CELLS RESPONDING TO SALMONELLA INFECTION
    Brad Cookson; Fiscal Year: 2005
    DESCRIPTION (Adapted from the Applicant's Abstract): Salmonella, Mycobacterium and Histoplasma are facultative intracellular pathogens that live inside phagosomes of host macrophages...
  73. INNATE/ADAPTIVE IMMUNE RESPONSE TO SALMONELLA TYPHIMURIUM
    MUYIWA EMMANUEL AWONIYI; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Nontyphoidal Salmonella (NTS) infections, including Salmonella typhimurium (Stym), are an important health concern worldwide...
  74. Salmonella SopA is a functional mimicry of eukaryotic E3 protein ubiquitin ligase
    Daoguo Zhou; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Salmonella enterica serovar Typhimurium causes mild gastroenteritis and more severe systematic infections in both humans and domestic animals...