enterobacteriaceae

Summary

Summary: A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.

Top Publications

  1. ncbi Extended-spectrum beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    Lancet Infect Dis 8:159-66. 2008
  2. pmc Extended-spectrum beta-lactamases: a clinical update
    David L Paterson
    Infectious Disease Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Microbiol Rev 18:657-86. 2005
  3. ncbi Identification of plasmids by PCR-based replicon typing
    Alessandra Carattoli
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Microbiol Methods 63:219-28. 2005
  4. pmc Global spread of Carbapenemase-producing Enterobacteriaceae
    Patrice Nordmann
    Bicetre Hospital, Le Kremlin Bicetre, France
    Emerg Infect Dis 17:1791-8. 2011
  5. ncbi Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae
    Karen Bush
    Biology Department, Indiana University Bloomington, Bloomington, IN 47405, USA
    Curr Opin Microbiol 13:558-64. 2010
  6. pmc Genetic features of blaNDM-1-positive Enterobacteriaceae
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 55:5403-7. 2011
  7. pmc The transmission efficiency of tomato yellow leaf curl virus by the whitefly Bemisia tabaci is correlated with the presence of a specific symbiotic bacterium species
    Yuval Gottlieb
    Agricultural Research Organization, Institute of Plant Protection, Department of Entomology, Volcani Center, Bet Dagan 50250, Israel
    J Virol 84:9310-7. 2010
  8. pmc Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae
    Bärbel Stecher
    Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 109:1269-74. 2012
  9. ncbi Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae
    Claudia Lupp
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Cell Host Microbe 2:119-29. 2007
  10. ncbi A multinational survey of risk factors for infection with extended-spectrum beta-lactamase-producing enterobacteriaceae in nonhospitalized patients
    Ronen Ben-Ami
    Infectious Diseases Unit and the 2Division of Epidemiology, Tel Aviv Medical Center, Tel Aviv, Israel
    Clin Infect Dis 49:682-90. 2009

Detail Information

Publications304 found, 100 shown here

  1. ncbi Extended-spectrum beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    Lancet Infect Dis 8:159-66. 2008
    ..From the late 1990s, multidrug-resistant Enterobacteriaceae (mostly Escherichia coli) that produce extended-spectrum beta lactamases (ESBLs), such as the CTX-M enzymes, ..
  2. pmc Extended-spectrum beta-lactamases: a clinical update
    David L Paterson
    Infectious Disease Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Microbiol Rev 18:657-86. 2005
    ..It has been proposed that cephalosporin breakpoints for the Enterobacteriaceae should be altered so that the need for ESBL detection would be obviated...
  3. ncbi Identification of plasmids by PCR-based replicon typing
    Alessandra Carattoli
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Microbiol Methods 63:219-28. 2005
    ..to develop a PCR method based on replicons (inc/rep PCR) of the major plasmid incompatibility groups among Enterobacteriaceae. Eighteen pairs of primers were designed to perform 5 multiplex- and 3 simplex-PCRs, recognizing FIA, FIB, ..
  4. pmc Global spread of Carbapenemase-producing Enterobacteriaceae
    Patrice Nordmann
    Bicetre Hospital, Le Kremlin Bicetre, France
    Emerg Infect Dis 17:1791-8. 2011
    Carbapenemases increasingly have been reported in Enterobacteriaceae in the past 10 years...
  5. ncbi Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae
    Karen Bush
    Biology Department, Indiana University Bloomington, Bloomington, IN 47405, USA
    Curr Opin Microbiol 13:558-64. 2010
    Resistance to β-lactams and other antibiotics in the Enterobacteriaceae is frequently associated with plasmidic resistance determinants that are easily transferred among species...
  6. pmc Genetic features of blaNDM-1-positive Enterobacteriaceae
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 55:5403-7. 2011
    ..The bla(NDM-1) plasmids coharbored a variety of resistance determinants, including β-lactamase genes, quinolone resistance genes, and 16S RNA methylase genes...
  7. pmc The transmission efficiency of tomato yellow leaf curl virus by the whitefly Bemisia tabaci is correlated with the presence of a specific symbiotic bacterium species
    Yuval Gottlieb
    Agricultural Research Organization, Institute of Plant Protection, Department of Entomology, Volcani Center, Bet Dagan 50250, Israel
    J Virol 84:9310-7. 2010
    ..The other symbionts from both biotypes do not seem to be involved in transmission of this virus...
  8. pmc Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae
    Bärbel Stecher
    Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 109:1269-74. 2012
    ..Pangenome analyses established particularly high levels of genetic flux between Gram-negative Enterobacteriaceae. However, the mechanisms fostering intraenterobacterial HGT are incompletely understood...
  9. ncbi Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae
    Claudia Lupp
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Cell Host Microbe 2:119-29. 2007
    ..inflammation supported the growth of either the resident or introduced aerobic bacteria, particularly of the Enterobacteriaceae family...
  10. ncbi A multinational survey of risk factors for infection with extended-spectrum beta-lactamase-producing enterobacteriaceae in nonhospitalized patients
    Ronen Ben-Ami
    Infectious Diseases Unit and the 2Division of Epidemiology, Tel Aviv Medical Center, Tel Aviv, Israel
    Clin Infect Dis 49:682-90. 2009
    Infections caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae are increasing in frequency and are associated with high mortality rates...
  11. ncbi Mucosal flora in inflammatory bowel disease
    Alexander Swidsinski
    Innere Klinik, Gastroenterologie, Charité Humboldt Universität, Berlin, Germany
    Gastroenterology 122:44-54. 2002
    ..Microorganisms that directly interact with the intestinal mucosa are obscured by fecal flora and poorly characterized...
  12. pmc Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis
    Wendy S Garrett
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cell Host Microbe 8:292-300. 2010
    ..Cross-fostering experiments indicated a role for these organisms in maternal transmission of disease. Our findings illustrate how gut microbial communities work in concert with specific culturable colitogenic agents to cause IBD...
  13. pmc Early dissemination of NDM-1- and OXA-181-producing Enterobacteriaceae in Indian hospitals: report from the SENTRY Antimicrobial Surveillance Program, 2006-2007
    Mariana Castanheira
    JMI Laboratories, North Liberty, Iowa 52317, USA
    Antimicrob Agents Chemother 55:1274-8. 2011
    Among 39 carbapenem-resistant Enterobacteriaceae (2...
  14. ncbi Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe
    R Canton
    Servicio de Microbiología and CIBER en Epidemiología y Salud Pública, Instituto Ramón y Cajal de Investigación Sanitaria and Hospital Universitario Ramón y Cajal, Madrid, Spain
    Clin Microbiol Infect 18:413-31. 2012
    Plasmid-acquired carbapenemases in Enterobacteriaceae, which were first discovered in Europe in the 1990s, are now increasingly being identified at an alarming rate...
  15. pmc Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in Enterobacteriaceae isolates from Polish hospitals
    Joanna Empel
    National Medicines Institute, 00 725 Warsaw, Poland
    Antimicrob Agents Chemother 52:2449-54. 2008
    The first national survey of resistance to newer beta-lactams in nosocomial populations of Enterobacteriaceae in Poland was performed...
  16. pmc Dissemination of blaKPC-2 by the spread of Klebsiella pneumoniae clonal complex 258 clones (ST258, ST11, ST437) and plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae species in Brazil
    Leonardo Neves Andrade
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil
    Antimicrob Agents Chemother 55:3579-83. 2011
    ..IncL/M, two untypeable plasmids carrying Tn4401a or Tn4401b) successfully disseminated among species of the Enterobacteriaceae (Enterobacter cloacae, Serratia marcescens, and Citrobacter freundii)...
  17. ncbi Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia
    Leyla Akman
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, 60 College Street, 606 LEPH, New Haven, Connecticut 06510, USA
    Nat Genet 32:402-7. 2002
    ..Unexpectedly, this obligate's genome bears hallmarks of both parasitic and free-living microbes, and the gene encoding the important regulatory protein DnaA is absent...
  18. ncbi Complete genome sequence of Salmonella enterica serovar Typhimurium LT2
    M McClelland
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, California 92121, USA
    Nature 413:852-6. 2001
    ..Most of these homologues were previously unknown, and 50 may be exported to the periplasm or outer membrane, rendering them accessible as therapeutic or vaccine targets...
  19. ncbi Infections with extended-spectrum beta-lactamase-producing enterobacteriaceae: changing epidemiology and drug treatment choices
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada
    Drugs 70:313-33. 2010
    ..Infections due to ESBL-producing Enterobacteriaceae are associated with a delay in initiation of appropriate antibacterial therapy, which consequently prolongs ..
  20. ncbi Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention
    Neil Gupta
    Epidemic Intelligence Service, Centers for Disease Control and Prevention, 1600 Clifton Road NE, MS A 35, Atlanta, GA 30333, USA
    Clin Infect Dis 53:60-7. 2011
    ..Klebsiella pneumoniae carbapenemase (KPC) has led to an increase in the prevalence of carbapenem-resistant Enterobacteriaceae (CRE) in the United States...
  21. ncbi Transfer of Pectobacterium chrysanthemi (Burkholder et al. 1953) Brenner et al. 1973 and Brenneria paradisiaca to the genus Dickeya gen. nov. as Dickeya chrysanthemi comb. nov. and Dickeya paradisiaca comb. nov. and delineation of four novel species, Dick
    Régine Samson
    UMR de Pathologie Végétale INRA INH Université, BP 57, 42 rue G Morel, 49071 Beaucouze, France
    Int J Syst Evol Microbiol 55:1415-27. 2005
    ..chrysanthemi and bv. parthenii), Dickeya dieffenbachiae sp. nov. (type strain CFBP 2051(T)=NCPPB 2976(T)), Dickeya dianthicola sp. nov. (type strain CFBP 1200(T)=NCPPB 453(T)) and Dickeya paradisiaca comb. nov., respectively...
  22. ncbi Development of a set of multiplex PCR assays for the detection of genes encoding important beta-lactamases in Enterobacteriaceae
    Caroline Dallenne
    Universite Pierre et Marie Curie Paris 6, Faculte de Medecine Pierre et Marie Curie, Departement de Bacteriologie, Paris, France
    J Antimicrob Chemother 65:490-5. 2010
    ....
  23. ncbi Bacteriophages encode factors required for protection in a symbiotic mutualism
    Kerry M Oliver
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    Science 325:992-4. 2009
    ..Thus, phages vector ecologically important traits, such as defense against parasitoids, within and among symbiont and animal host lineages...
  24. ncbi Trends in production of extended-spectrum beta-lactamases among Enterobacteriaceae of clinical interest: results of a nationwide survey in Belgian hospitals
    H Rodriguez-Villalobos
    Laboratoire de Microbiologie, Hopital Universitaire Erasme, Universite Libre de Bruxelles, B 1070 Brussels, Belgium
    J Antimicrob Chemother 66:37-47. 2011
    to assess the frequency and diversity of extended-spectrum β-lactamases (ESBLs) in Enterobacteriaceae isolates in Belgium.
  25. pmc AmpC beta-lactamases
    George A Jacoby
    Lahey Clinic, Burlington, Massachusetts 01805, USA
    Clin Microbiol Rev 22:161-82, Table of Contents. 2009
    AmpC beta-lactamases are clinically important cephalosporinases encoded on the chromosomes of many of the Enterobacteriaceae and a few other organisms, where they mediate resistance to cephalothin, cefazolin, cefoxitin, most penicillins, ..
  26. ncbi Prevalence of endosymbionts in Bemisia tabaci populations and their in vivo sensitivity to antibiotics
    Muhammad Z Ahmed
    Department of Entomology, South China Agricultural University, Guangzhou 510640, People s Republic of China
    Curr Microbiol 61:322-8. 2010
    ....
  27. ncbi Emergence of Enterobacteriaceae producing extended-spectrum beta-lactamases (ESBLs) in the community
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, Alberta, Canada
    J Antimicrob Chemother 56:52-9. 2005
    b>Enterobacteriaceae, especially Klebsiella spp. producing extended-spectrum beta-lactamases (ESBLs) such as SHV and TEM types, have been established since the 1980s as a major cause of hospital-acquired infections...
  28. pmc Carbapenemases: the versatile beta-lactamases
    Anne Marie Queenan
    Johnson and Johnson Pharmaceutical Research and Development, L L C, Raritan, NJ 08869, USA
    Clin Microbiol Rev 20:440-58, table of contents. 2007
    ..however, there are increasing numbers of reports worldwide of this group of beta-lactamases in the Enterobacteriaceae. This review updates the characteristics, epidemiology, and detection of the carbapenemases found in ..
  29. ncbi Prospective evaluation of colonization with extended-spectrum beta-lactamase (ESBL)-producing enterobacteriaceae among patients at hospital admission and of subsequent colonization with ESBL-producing enterobacteriaceae among patients during hospitalizati
    Reuven Friedmann
    Department of Geriatrics, Shaare Zedek Medical Center, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Infect Control Hosp Epidemiol 30:534-42. 2009
    To determine the rates of and risk factors for carriage and acquisition of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae during hospitalization.
  30. pmc Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Arizona Genomics Institute, University of Arizona, Tucson, AZ 85721 USA
    Proc Natl Acad Sci U S A 106:9063-8. 2009
    ..The genome is also littered with mobile DNA, including phage-derived genes, plasmids, and insertion-sequence elements, highlighting its dynamic nature and the continued role horizontal gene transfer plays in shaping it...
  31. pmc Arsenophonus, an emerging clade of intracellular symbionts with a broad host distribution
    Eva Novakova
    Faculty of Science, University of South Bohemia, Branisovska 31, Ceske Budejovice 37005, Czech Republic
    BMC Microbiol 9:143. 2009
    ....
  32. ncbi Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae
    Claudia Lupp
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Cell Host Microbe 2:204. 2007
    ..inflammation supported the growth of either the resident or introduced aerobic bacteria, particularly of the Enterobacteriaceae family...
  33. ncbi Mortality and delay in effective therapy associated with extended-spectrum beta-lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysis
    Mitchell J Schwaber
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Antimicrob Chemother 60:913-20. 2007
    We performed a systematic review and meta-analysis to examine the impact of extended-spectrum beta-lactamase (ESBL) production on mortality and delay in effective therapy in Enterobacteriaceae bacteraemia.
  34. pmc Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects
    Patrick H Degnan
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
    Genome Res 15:1023-33. 2005
    ..Furthermore, the increased rates of amino acid substitution and gene loss in Blochmannia have occurred in a lineage-specific fashion, which may reflect life history differences of their ant hosts...
  35. pmc "Candidatus Curculioniphilus buchneri," a novel clade of bacterial endocellular symbionts from weevils of the genus Curculio
    Hirokazu Toju
    National Institute of Advanced Industrial Science and Technology AIST, Tsukuba 305 8566, Japan
    Appl Environ Microbiol 76:275-82. 2010
    ..We suggest that such Sodalis-allied secondary symbionts in weevils might provide a potential source for symbiont replacements, as has occurred in an ancestor of Sitophilus grain weevils...
  36. ncbi Prevalence and clonality of extended-spectrum beta-lactamases in Asia
    P M Hawkey
    Division of Immunity and Infection, University of Birmingham, Birmingham and Health Protection Agency, West Midlands Public Health Laboratory, Birmingham Heart of England NHS Trust, Bordesley Green East, Birmingham, UK
    Clin Microbiol Infect 14:159-65. 2008
    ..to mobile genetic elements in human-associated Enterobacteriaceae. ESBL production rates are now very high compared with Europe...
  37. ncbi Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates
    D M Livermore
    Antibiotic Resistance Monitoring and Reference Laboratory, HPA Microbiology Services, London, UK
    J Antimicrob Chemother 66:48-53. 2011
    the emergence of carbapenemases in Enterobacteriaceae is driving a search for therapeutic alternatives...
  38. pmc oqxAB encoding a multidrug efflux pump in human clinical isolates of Enterobacteriaceae
    Hong Bin Kim
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
    Antimicrob Agents Chemother 53:3582-4. 2009
    ..IS26-like sequences flanked the plasmid-mediated oqxAB genes, suggesting that they had been mobilized as part of a composite transposon...
  39. ncbi Identification and molecular characterisation of New Delhi metallo-β-lactamase-1 (NDM-1)- and NDM-6-producing Enterobacteriaceae from New Zealand hospitals
    Deborah A Williamson
    Department of Clinical Microbiology, Auckland District Health Board, Park Road, Grafton, Auckland, New Zealand
    Int J Antimicrob Agents 39:529-33. 2012
    ..This study sought to determine whether bla(NDM) was present in Enterobacteriaceae isolates displaying resistance to carbapenems that were submitted to the National Antibiotic Reference ..
  40. pmc Genome sequence of the plant-pathogenic bacterium Dickeya dadantii 3937
    Jeremy D Glasner
    Department of Genetics and Genome Center of Wisconsin, University of Wisconsin Madison, Madison, WI 53706, USA
    J Bacteriol 193:2076-7. 2011
    ..We present here the sequence of strain 3937, a strain widely used as a model system for research on the molecular biology and pathogenicity of this group of bacteria...
  41. ncbi Tigecycline for the treatment of multidrug-resistant Enterobacteriaceae: a systematic review of the evidence from microbiological and clinical studies
    Theodoros Kelesidis
    Alfa Institute of Biomedical Sciences, Athens, Greece
    J Antimicrob Chemother 62:895-904. 2008
    Antimicrobial drug resistance is spreading among Enterobacteriaceae, limiting the utility of traditionally used agents...
  42. ncbi Phylogenetic position of phytopathogens within the Enterobacteriaceae
    L Hauben
    Laboratorium voor Microbiologie, Universiteit Gent, Belgium
    Syst Appl Microbiol 21:384-97. 1998
    ..the genera Erwinia, Pantoea and Enterobacter were determined and compared with those of other members of the Enterobacteriaceae. The species of the genus Erwinia may be divided into three phylogenetic groups...
  43. ncbi New Delhi Metallo-beta lactamase (NDM-1) in Enterobacteriaceae: treatment options with carbapenems compromised
    Payal Deshpande
    Dept of Research, P D Hinduja National Hospital and Medical Research Centre, Mumbai, India
    J Assoc Physicians India 58:147-9. 2010
    ..An alert issued in the UK in 2009 warned of an increasing number of carbapenem resistant Enterobacteriaceae strains identified in UK hospital patients...
  44. pmc Mauve: multiple alignment of conserved genomic sequence with rearrangements
    Aaron C E Darling
    Department of Computer Science, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Genome Res 14:1394-403. 2004
    ..We have evaluated the quality of Mauve alignments and drawn comparison to other methods through extensive simulations of genome evolution...
  45. ncbi Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum (beta)-lactamases
    Neil Woodford
    J Antimicrob Chemother 57:154-5. 2006
  46. ncbi Biotype-dependent secondary symbiont communities in sympatric populations of Bemisia tabaci
    E Chiel
    Department of Entomology, Newe Ya ar Research Center, ARO, Ramat Yishai 30095, Israel
    Bull Entomol Res 97:407-13. 2007
    ..The association found between whitefly biotypes and secondary symbionts suggests a possible contribution of these bacteria to host characteristics such as insecticide resistance, host range, virus transmission and speciation...
  47. ncbi Prevalence and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Europe
    R Canton
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Clin Microbiol Infect 14:144-53. 2008
    ....
  48. pmc Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme
    Chi Hye Park
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 2696, USA
    Antimicrob Agents Chemother 50:3953-5. 2006
    Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of >/=0.25 microg/ml and reduced susceptibility to ceftazidime, aac(6')-Ib was present in 50...
  49. pmc Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258
    Brandon Kitchel
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Antimicrob Agents Chemother 53:3365-70. 2009
    Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae have become more common in the United States and throughout the world...
  50. pmc AmpC disk test for detection of plasmid-mediated AmpC beta-lactamases in Enterobacteriaceae lacking chromosomal AmpC beta-lactamases
    Jennifer A Black
    Center for Research in Antiinfectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    J Clin Microbiol 43:3110-3. 2005
    ..The test is a potentially useful diagnostic tool. It can provide important infection control information and help to ensure that infected patients receive appropriate antibiotic therapy...
  51. ncbi Phenotypic detection of extended-spectrum beta-lactamase production in Enterobacteriaceae: review and bench guide
    L Drieux
    INSERM, U655 LRMA, Faculté de Médecine Pierre et Marie Curie site Pitié Salpêtrière, Universite Pierre et Marie Curie Paris 6, Paris, France
    Clin Microbiol Infect 14:90-103. 2008
    Strains of Enterobacteriaceae producing an extended spectrum beta-lactamase have become a concern in medical bacteriology as regards both antimicrobial treatment and infection control in hospitals...
  52. pmc Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment
    Mario Tumbarello
    Istituto Malattie Infettive, Universita Cattolica del Sacro Cuore, Largo A Gemelli 8, 00168 Rome, Italy
    Antimicrob Agents Chemother 51:1987-94. 2007
    ..analysis to identify risk factors for mortality in adult in-patients with BSI caused by ESBL-producing Enterobacteriaceae (ESBL-BSI)...
  53. ncbi A new Sodalis lineage from bloodsucking fly Craterina melbae (Diptera, Hippoboscoidea) originated independently of the tsetse flies symbiont Sodalis glossinidius
    Eva Novakova
    Faculty of Biological Sciences and Institute of Parasitology, Ceske Budejovice, Czech Republic
    FEMS Microbiol Lett 269:131-5. 2007
    ....
  54. pmc Common and divergent features in transcriptional control of the homologous small RNAs GlmY and GlmZ in Enterobacteriaceae
    Yvonne Göpel
    Department of General Microbiology, Institute of Microbiology and Genetics, Georg August University, Grisebachstrasse 8, 37077 Gottingen, Germany
    Nucleic Acids Res 39:1294-309. 2011
    Small RNAs GlmY and GlmZ compose a cascade that feedback-regulates synthesis of enzyme GlmS in Enterobacteriaceae. Here, we analyzed the transcriptional regulation of glmY/glmZ from Yersinia pseudotuberculosis, Salmonella typhimurium and ..
  55. pmc How to detect NDM-1 producers
    Patrice Nordmann
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    J Clin Microbiol 49:718-21. 2011
    ..Colonies growing on these screening media can be verified as NDM-1 producers with molecular methods as described herein...
  56. pmc Characterization of a chromosomally encoded extended-spectrum class A beta-lactamase from Kluyvera cryocrescens
    J W Decousser
    , , , , , France
    Antimicrob Agents Chemother 45:3595-8. 2001
    ..The substrate profile of KLUC-1 corresponded to that of CTX-M-type enzymes...
  57. ncbi Evidence for multiple acquisition of Arsenophonus by whitefly species (Sternorrhyncha: Aleyrodidae)
    MyLo Ly Thao
    Microbiology Section, University of California, One Shields Ave, Davis, CA 95616 8665, USA
    Curr Microbiol 48:140-4. 2004
    ..These results suggest that, unlike the primary endosymbiont, Arsenophonus may infect whiteflies multiple times and may also be horizontally transmitted...
  58. pmc Mobile genetic element proliferation and gene inactivation impact over the genome structure and metabolic capabilities of Sodalis glossinidius, the secondary endosymbiont of tsetse flies
    Eugeni Belda
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Spain
    BMC Genomics 11:449. 2010
    ....
  59. ncbi Screening for extended-spectrum beta-lactamase-producing Enterobacteriaceae among high-risk patients and rates of subsequent bacteremia
    P Reddy
    Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Clin Infect Dis 45:846-52. 2007
    Bloodstream infections due to extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae have been associated with increased hospital costs, length of stay, and patient mortality...
  60. ncbi Sodalis gen. nov. and Sodalis glossinidius sp. nov., a microaerophilic secondary endosymbiont of the tsetse fly Glossina morsitans morsitans
    C Dale
    Division of Molecular Genetics, University of Glasgow, UK
    Int J Syst Bacteriol 49:267-75. 1999
    ..m. morsitans should be classified in a new genus Sodalis gen. nov., as Sodalis glossinidius gen. nov., sp. nov. Strain M1T is the type strain for this new species...
  61. ncbi Independent origins and horizontal transfer of bacterial symbionts of aphids
    J P Sandström
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson 85721, USA
    Mol Ecol 10:217-28. 2001
    ..Three types of bacteria besides Buchnera were found repeatedly; all three fall within the Enterobacteriaceae. The R-type has a 16S rDNA less than 0...
  62. pmc Diversity among the tailed-bacteriophages that infect the Enterobacteriaceae
    Sherwood R Casjens
    Department of Pathology, Room 5200K EEJMRB, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Res Microbiol 159:340-8. 2008
    Complete genome sequences have been determined for 73 tailed-phages that infect members of the bacterial Enterobacteriaceae family...
  63. pmc Gut microbial colonisation in premature neonates predicts neonatal sepsis
    Juliette C Madan
    Department of Pediatrics, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03753, USA
    Arch Dis Child Fetal Neonatal Ed 97:F456-62. 2012
    ..Understanding microbial colonisation of the gut in prematurity may predict risk of sepsis to guide future strategies to manipulate the microbiome...
  64. pmc In vivo efficacy of a human-simulated regimen of ceftaroline combined with NXL104 against extended-spectrum-beta-lactamase (ESBL)-producing and non-ESBL-producing Enterobacteriaceae
    Dora E Wiskirchen
    Center for Anti Infective Research and Development, Hartford Hospital, Hartford, Connecticut 06102, USA
    Antimicrob Agents Chemother 55:3220-5. 2011
    ..exhibits in vitro activity against extended-spectrum β-lactamase (ESBL)-, AmpC-, and KPC-producing Enterobacteriaceae when combined with the novel β-lactamase inhibitor NXL104...
  65. ncbi Gut bacterial communities in the Mediterranean fruit fly (Ceratitis capitata) and their impact on host longevity
    A Behar
    Department of Plant Pathology and Microbiology, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, 76100 Rehovot, Israel
    J Insect Physiol 54:1377-83. 2008
    ..harbor stable bacterial communities in their digestive system, composed mainly of members of the Enterobacteriaceae. However, the Enterobacteriaceae are not the sole community in this habitat...
  66. ncbi Surveillance of extended-spectrum-beta-lactamase-producing Enterobacteriaceae in a Swiss Tertiary Care Hospital
    C Fankhauser
    Infection Control Programme, University of Geneva Hospitals, Geneva, Switzerland
    Swiss Med Wkly 139:747-51. 2009
    Extended spectrum beta-lactamase producing enterobacteriaceae (ESBL-E) are increasing worldwide, but there is sparse data on patient-to-patient transmission and the prevalence among risk groups in Switzerland...
  67. pmc Symbiont infection affects aphid defensive behaviours
    Emilie Dion
    UMR 1099 INRA Agrocampus Ouest Université Rennes 1 Biologie des Organismes et des Populations appliquée à la Protection des Plantes, 65 rue de Saint Brieuc CS 84215, 35042, Rennes Cedex, France
    Biol Lett 7:743-6. 2011
    ..Such symbiont-induced changes of behavioural defences may have consequences for coevolutionary processes between host organisms and their enemies...
  68. ncbi Clinical epidemiology of carbapenem-intermediate or -resistant Enterobacteriaceae
    Nimish Patel
    Pharmacy Practice Department, Albany College of Pharmacy and Health Sciences, Albany, NY 12208 3492, USA
    J Antimicrob Chemother 66:1600-8. 2011
    Despite the increasing incidence of carbapenem-intermediate or -resistant Enterobacteriaceae (CIRE), risk factors associated with CIRE infections have not been well defined...
  69. pmc Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemase-Producing Enterobacteriaceae
    David M Livermore
    Antibiotic Resistance Monitoring and Reference Laboratory, HPA Centre for Infections, London, United Kingdom
    Antimicrob Agents Chemother 55:390-4. 2011
    Combinations of NXL104 with ceftazidime and aztreonam were tested against carbapenem-resistant members of the Enterobacteriaceae. Ceftazidime-NXL104 was active against strains with the OXA-48 enzyme or with combinations of impermeability ..
  70. ncbi Symbiont diversity and non-random hybridization among indigenous (Ms) and invasive (B) biotypes of Bemisia tabaci
    M Thierry
    CIRAD, UMR PVBMT Cirad Universite de La Reunion, Pole de protection des plantes, 7 chemin de l IRAT, 97410 Saint Pierre, Ile de La Réunion, France
    Mol Ecol 20:2172-87. 2011
    ..Taken together, our results suggest that Cardinium and/or Arsenophonus may manipulate the reproduction of indigenous (Ms) with invasive (B) biotypes of Bemisia tabaci...
  71. ncbi The efficacy of infection control interventions in reducing the incidence of extended-spectrum β-lactamase-producing Enterobacteriaceae in the nonoutbreak setting: A systematic review
    Shannon Goddard
    Department of Medicine, University of Toronto, Canada
    Am J Infect Control 39:599-601. 2011
    ..review to examine the efficacy of infection control interventions for the control of ESBL-producing Enterobacteriaceae in hospitals in the non-outbreak setting...
  72. ncbi Massive production of butanediol during plant infection by phytopathogenic bacteria of the genera Dickeya and Pectobacterium
    Géraldine Effantin
    Universite de Lyon, Universite Lyon 1, INSA Lyon, Microbiologie Adaptation et Pathogénie, CNRS UMR5240, Domaine Scientifique de la Doua, 69622 Villeurbanne, France
    Mol Microbiol 82:988-97. 2011
    ..These data highlight the importance of butanediol metabolism in limiting acidification of the plant tissue during the development of the soft-rot disease caused by pectinolytic enterobacteria...
  73. pmc Functional characterization of IS1999, an IS4 family element involved in mobilization and expression of beta-lactam resistance genes
    Daniel Aubert
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    J Bacteriol 188:6506-14. 2006
    ..This reduced transposition frequency of IS1999.2-based elements may result from a lower transcription of the transposase gene, as revealed by reverse transcription-PCR analyses...
  74. ncbi Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Enterobacteriaceae other than Escherichia coli
    Anja Schumacher
    Center for Infectious Diseases and Travel Medicine, Department of Medicine, University Hospital, Freiburg, Germany
    J Antimicrob Chemother 57:344-8. 2006
    1-(1-Naphthylmethyl)-piperazine (NMP) has been shown to reverse multidrug resistance (MDR) in Escherichia coli overexpressing RND type efflux pumps, but there is no data on its activity in Enterobacteriaceae other than E. coli.
  75. ncbi A structural view of the antibiotic degradation enzyme NDM-1 from a superbug
    Yu Guo
    High throughput Molecular Drug Discovery Center, Tianjin Joint Academy of Biotechnology and Medicine, Tianjin, China
    Protein Cell 2:384-94. 2011
    Gram-negative Enterobacteriaceae with resistance to carbapenem conferred by New Delhi metallo-β-lactamase 1 (NDM-1) are a type of newly discovered antibioticresistant bacteria...
  76. ncbi Antimicrobial resistance patterns in Enterobacteriaceae isolated from an urban wastewater treatment plant
    Miguel Ferreira da Silva
    Escola Superior de Biotecnologia, Universidade Catolica Portuguesa, 4200 072 Porto, Portugal
    FEMS Microbiol Ecol 60:166-76. 2007
    ..The variable regions of class 1 integrons, detected in c. 10% of the Escherichia spp. isolates, contained predominantly the gene cassettes aadA1/dhfrI...
  77. ncbi Evaluation of different laboratory tests for the detection of metallo-beta-lactamase production in Enterobacteriaceae
    Irene Galani
    4th Department of Internal Medicine, Molecular Biology Section, University of Athens Medical School, Athens, Greece
    J Antimicrob Chemother 61:548-53. 2008
    ....
  78. pmc Spread of OXA-48-encoding plasmid in Turkey and beyond
    Amélie Carrër
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 54:1369-73. 2010
    ..That gene was located within either transposon Tn1999 or transposon Tn1999.2, which was always inserted within the same gene. This work highlights the current plasmid-mediated dissemination of the OXA-48 carbapenemase worldwide...
  79. ncbi Loss of DNA recombinational repair enzymes in the initial stages of genome degeneration
    Colin Dale
    Department of Biochemistry and Molecular Biophysics, University of Arizona, USA
    Mol Biol Evol 20:1188-94. 2003
    ..Similar events may be pervasive during the evolution of symbiosis because symbiont genomes typically lack recombinational repair genes and have reduced numbers of ribosomal operons...
  80. pmc Extended-spectrum β-lactamase genes of Escherichia coli in chicken meat and humans, The Netherlands
    Ilse Overdevest
    St Elisabeth Hospital, Tilburg, The Netherlands
    Emerg Infect Dis 17:1216-22. 2011
    We determined the prevalence and characteristics of extended-spectrum β-lactamase (ESBL) genes of Enterobacteriaceae in retail chicken meat and humans in the Netherlands...
  81. pmc Evolutionary relationships of three new species of Enterobacteriaceae living as symbionts of aphids and other insects
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, Biological Sciences West 310, University of Arizona, Tucson, Arizona 85721, USA
    Appl Environ Microbiol 71:3302-10. 2005
    ..All three symbionts are in the Enterobacteriaceae. One of the symbionts, here given the provisional designation "Candidatus Serratia symbiotica," is a ..
  82. ncbi The draft genome sequence of Arsenophonus nasoniae, son-killer bacterium of Nasonia vitripennis, reveals genes associated with virulence and symbiosis
    T E Wilkes
    School of Biological Sciences, University of Liverpool, Liverpool, UK
    Insect Mol Biol 19:59-73. 2010
    ..nasoniae and its Nasonia host are useful tools for examining functional genomic interactions of microbial survival in hostile immune environments, and mechanisms of passage through gut epithelia, in a whole organism context...
  83. pmc Diverse phage-encoded toxins in a protective insect endosymbiont
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721 0088, USA
    Appl Environ Microbiol 74:6782-91. 2008
    ..Thus, phage may act as a conduit for ongoing gene exchange among heritable endosymbionts...
  84. ncbi The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria
    Patrice Nordmann
    Service de Bactériologie Virologie Hygiène, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine and Université Paris Sud, K Bicêtre, France
    Lancet Infect Dis 9:228-36. 2009
    From early this decade, Enterobacteriaceae that produce Klebsiella pneumoniae carbapenemases (KPC) were reported in the USA and subsequently worldwide...
  85. ncbi Genotypic variation and the role of defensive endosymbionts in an all-parthenogenetic host-parasitoid interaction
    Christoph Vorburger
    Institute of Zoology, University of Zurich, 8057 Zurich, Switzerland
    Evolution 63:1439-50. 2009
    ..defensa does not go to fixation and highlights the need to develop new models to understand the dynamics of endosymbiont-mediated coevolution...
  86. pmc Evolutionary convergence and nitrogen metabolism in Blattabacterium strain Bge, primary endosymbiont of the cockroach Blattella germanica
    Maria J López-Sánchez
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Valencia, Spain
    PLoS Genet 5:e1000721. 2009
    ..Here, we explain the metabolic reasons underlying the enigmatic return of cockroaches to the ancestral ammonotelic state...
  87. ncbi From bench to bedside: stealth of enteroinvasive pathogens
    Renee M Tsolis
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, 95616 California, USA
    Nat Rev Microbiol 6:883-92. 2008
    ..Host responses contribute to the clinical presentation of disease and improved understanding of these responses in the laboratory is beginning to bridge the gap between bench and bedside...
  88. pmc Evaluation of methods to identify the Klebsiella pneumoniae carbapenemase in Enterobacteriaceae
    K F Anderson
    Centers for Disease Control and Prevention, Division of Healthcare Quality Promotion, Mail Stop G 08, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    J Clin Microbiol 45:2723-5. 2007
    The Klebsiella pneumoniae carbapenem (KPC) beta-lactamase occurs in Enterobacteriaceae and can confer resistance to all beta-lactam agents including carbapenems...
  89. ncbi An antimicrobial peptide with trypanocidal activity characterized from Glossina morsitans morsitans
    Youjia Hu
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University, School of Medicine, 60 College St, 606 LEPH, New Haven, CT 06510, USA
    Insect Biochem Mol Biol 35:105-15. 2005
    ..We discuss a paratransgenic strategy, which involves the expression of trypanocidal molecules such as recGmAttA1 in the midgut symbiont Sodalis in vivo to reduce trypanosome transmission...
  90. pmc Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes
    Deo Prakash Pandey
    Department of Biochemistry and Molecular Biology, University of Southern Denmark DK 5230 Odense M, Denmark
    Nucleic Acids Res 33:966-76. 2005
    ....
  91. ncbi Novel CTX-M {beta}-lactamase genotype distribution and spread into multiple species of Enterobacteriaceae in Changsha, Southern China
    Wen en Liu
    Xiangya Hospital, Central South University, Changsha, Hunan, P R China
    J Antimicrob Chemother 63:895-900. 2009
    The aim of this study was to undertake a survey of the occurrence of CTX-M and SHV extended-spectrum beta-lactamase (ESBL) genotypes in Enterobacteriaceae from Hunan Province, China.
  92. ncbi Therapeutic options for infections with Enterobacteriaceae producing carbapenem-hydrolyzing enzymes
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Future Microbiol 6:653-66. 2011
    b>Enterobacteriaceae that produce serine carbapenemases or metallo-β-lactamases, such as KPC, OXA-48, VIM or NDM, respectively, are spreading mostly as nosocomial pathogens worldwide...
  93. ncbi Activity of tigecycline alone and in combination with colistin and meropenem against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae strains by time-kill assay
    Spyros Pournaras
    Department of Microbiology, Medical School, University of Thessaly, Larissa, Greece
    Int J Antimicrob Agents 37:244-7. 2011
    ..with colistin and meropenem was tested against eight genetically unrelated KPC-producing clinical strains of Enterobacteriaceae (four K...
  94. pmc Lambda red-mediated genetic modification of the insect endosymbiont Sodalis glossinidius
    Mauricio H Pontes
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA
    Appl Environ Microbiol 77:1918-20. 2011
    ..This work greatly facilitates the application of genetics to the study of insect symbionts and should also prove useful in the context of long-awaited paratransgenic insect control strategies...
  95. ncbi Effects of a Lactobacillus casei synbiotic on serum lipoprotein, intestinal microflora, and organic acids in rats
    M T Liong
    School of Molecular Sciences, Victoria University, Werribee Campus, PO Box 14428, Melbourne, 8001, Australia
    J Dairy Sci 89:1390-9. 2006
    ..casei ASCC 292, fructooligosaccharide, and maltodextrin beneficially altered cholesterol levels and produced a healthier bowel microbial population without translocation of lactobacilli to other organs...
  96. ncbi Strategies of the home-team: symbioses exploited for vector-borne disease control
    Rita V M Rio
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510, USA
    Trends Microbiol 12:325-36. 2004
    ..Replacing susceptible insect genotypes with modified counterparts with reduced pathogen transmission ability, might provide a new set of armaments in the battle for vector-borne disease reduction...
  97. pmc Cefotaxime-resistant Enterobacteriaceae isolates from a hospital in Warsaw, Poland: identification of a new CTX-M-3 cefotaxime-hydrolyzing beta-lactamase that is closely related to the CTX-M-1/MEN-1 enzyme
    M Gniadkowski
    Sera and Vaccines Central Research Laboratory, Warsaw, Poland
    Antimicrob Agents Chemother 42:827-32. 1998
    ..Our results suggest that CTX-M genes have been spread among different species of the family Enterobacteriaceae in the hospital and that the CTX-M-3-expressing C...
  98. pmc International spread and persistence of TEM-24 is caused by the confluence of highly penetrating enterobacteriaceae clones and an IncA/C2 plasmid containing Tn1696::Tn1 and IS5075-Tn21
    Angela Novais
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Carretera de Colmenar, Km 9 1, Madrid 28034, Spain
    Antimicrob Agents Chemother 54:825-34. 2010
    TEM-24 remains one of the most widespread TEM-type extended-spectrum beta-lactamases (ESBLs) among Enterobacteriaceae. To analyze the reasons influencing its spread and persistence, a multilevel population genetics study was carried out ..
  99. ncbi Molecular diagnosis of Raoultella planticola infection of a surgical site
    R Wolcott
    Southwest Regional Wound Care Center, Lubbock, Texas, USA
    J Wound Care 19:329-32. 2010
    ..This pathogen was diagnosed with rapid clinical molecular pathogen diagnostic methods, which allowed an appropriate therapy to be implemented, thereby improving prognosis...
  100. ncbi Tetracycline resistance genes and tetracycline resistant lactose-fermenting Enterobacteriaceae in activated sludge of sewage treatment plants
    Tong Zhang
    Environmental Biotechnology Laboratory, Department of Civil Engineering, The University of Hong Kong, Hong Kong SAR, China
    Environ Sci Technol 43:3455-60. 2009
    ..Additionally, 109 lactose-fermenting Enterobacteriaceae (LFE) strains were isolated from the activated sludge of the Shatin STP...
  101. ncbi Description of four novel species of Xenorhabdus, family Enterobacteriaceae: Xenorhabdus budapestensis sp. nov., Xenorhabdus ehlersii sp. nov., Xenorhabdus innexi sp. nov., and Xenorhabdus szentirmaii sp. nov
    Katalin Lengyel
    Eotvos Lorand University, Faculty of Natural Sciences, Department of Genetics, Budapest, Hungary
    Syst Appl Microbiol 28:115-22. 2005
    ..nov., type strain DSM 16336T isolated from Steinernema scapterisci; and Xenorhabdus szentirmaii sp. nov., type strain DSM 16338T, isolated from Steinernema rarum...

Research Grants62

  1. Helicobacter pylori LPS Signaling and Role in Chronicity
    JOANNA GOLDBERG; Fiscal Year: 2005
    ..pylori is the lipid A moeity of its lipopolysaccharide (LPS). Compared to the prototypical Enterobacteriaceae lipid A, it has a unique structure and is much reduced in its endotoxic activity. Our hypothesis is that H...
  2. Mucosal Immunity and Microbiota in Intestinal Graft-versus-Host Disease
    Marcel R m van den Brink; Fiscal Year: 2013
    ..loss of microbial diversity, dysbiosis (imbalance of intestinal flora) and the expansion of Lactobacillus or Enterobacteriaceae, which have opposite effects on GVHD. Moreover, pre-BMT antibiotic use could aggravate GVHD...
  3. National surveillance of emerging MDR in pediatric Enterobacteriaceae infections
    Danielle M Zerr; Fiscal Year: 2013
    ..significant and very worrisome increases in plasmid-borne, broad-spectrum 2-lactam resistance (PBLR) in Enterobacteriaceae at our pediatric center...
  4. Reciprocal Control of Motility and Adherence in UTI
    Harry L Mobley; Fiscal Year: 2013
    ..Both E. coli and P. mirabilis are members of the Enterobacteriaceae, are motile, and produce a battery of fimbriae by which they mediate adherence to the uroepithelium...
  5. Rapid, automated, detection of viral and bacterial pathogens causing meningitis
    Andrew Hemmert; Fiscal Year: 2013
    ..with five new assays to detect the following ME-causing organisms directly from cerebrospinal fluid (CSF): Enterobacteriaceae, E. coli, Enterococcus species, H. influenza, L. monocytogenes, Mycoplasma pneumoniae, N. meningitidis, P...
  6. RmpA, a unique virulence regulator in emerging Klebsiella pneumoniae
    Valley J Stewart; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The family Enterobacteriaceae includes an array of human, animal and plant pathogens...
  7. Preserving beta-lactam utility against pathogens producing all classes of beta-la
    LUIGI XERRI; Fiscal Year: 2012
    ..all classes of b-lactamases is critically important in light of the alarming increase in clinical strains of Enterobacteriaceae carrying mixed serine- and metallo-enzymes...
  8. Bacterial Infection in COPD
    Sanjay Sethi; Fiscal Year: 2013
    ..The relationship of acquisition of new strains of Enterobacteriaceae and Staphylococcus aureus with exacerbations will be systematically examined...
  9. The molecular basis of epidemic blaKPC Klebsiella pneumoniae and Enterobacteriace
    BARRY NEAL KREISWIRTH; Fiscal Year: 2010
    ..of infecting isolates over the 5-year project period, including other emerging carbapenem-resistant Enterobacteriaceae. These studies will involve extensive molecular characterization of the isolates, physical and genetic ..
  10. Contribution of Novel Frimbriae to Proteus Mirabilis Virulence
    Melanie M Pearson; Fiscal Year: 2013
    ..S. Proteus mirabilis, a member of the Enterobacteriaceae, is a major cause of infection in individuals with complicated urinary tracts...
  11. Preserving beta-lactam utility vs pathogens producing any class of beta-lactamase
    LUIGI XERRI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Multi-drug resistance in Enterobacteriaceae is regarded as a healthcare crisis...
  12. National surveillance of emerging MDR in pediatric Enterobacteriaceae infections
    Danielle Zerr; Fiscal Year: 2009
    ..and very worrisome increases in plasmid-borne, broad-spectrum [unreadable]-lactam resistance (PBLR) in Enterobacteriaceae at our pediatric center...
  13. The molecular basis of the epidemic blaKPC gene Klebsiella
    BARRY NEAL KREISWIRTH; Fiscal Year: 2013
    ..of infecting isolates over the 5-year project period, including other emerging carbapenem-resistant Enterobacteriaceae. These studies will involve extensive molecular characterization of the isolates, physical and genetic ..
  14. Novel Compounds Targeting Bacterial PBPs
    LUIGI XERRI; Fiscal Year: 2013
    ..aureus and S. pneumoniae) and both wild-type and ESBL-expressing gram negatives in the Enterobacteriaceae family (E. coli and K. pneumoniae)...
  15. Differences in infecting and colonizing Enterobacteriaceae from short-course vs s
    Scott J Weissman; Fiscal Year: 2013
    ..coli or K. pneumoniae, these findings would make a significant impact on prescribing behavior, toward reducing pediatric antibiotic exposure and thus the selection for resistance. ..
  16. ROLE OF YAPS IN Y. PESTIS PATHOGENESIS
    Virginia L Miller; Fiscal Year: 2010
    ..However, Y. pestis is typically a pathogen of rodents, and is unique among the Enterobacteriaceae in using a blood-sucking insect (flea) for transmission. Y...
  17. Pharmacokinetic-Pharmacodynamics of Antimicrobials in Resistant Infections
    Jennifer Le; Fiscal Year: 2013
    ..methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae, have become an increasing therapeutic challenge...
  18. Novel Metallo-beta-lactamase Inhibitors
    LUIGI XERRI; Fiscal Year: 2012
    ..of this family of enzymes such as NDM-1 are found on mobile genetic elements which are rapidly spreading in Enterobacteriaceae and threaten to erode the future utility of the [unreadable]- lactam antibiotics (i.e...
  19. Multi-Drug Resistant Urinary Tract Infections in Ambulatory Settings
    Ebbing Lautenbach; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Significant increases in multidrug-resistant Enterobacteriaceae (e.g., Escherichia coli, Klebsiella pneumoniae) have been noted over the past decade...
  20. Adaptive evolution of pathogenesis towards symbiosis
    Serap Aksoy; Fiscal Year: 2009
    ..research interest since they are closely related to important free-living and pathogenic bacteria of the Enterobacteriaceae. The genomes of Wigglesworthia, Sodalis and Trypanosoma spp...
  21. Evaluation of Salmonella in Symptomatic and Asymptomatic Pets: Study for the Vet-
    Shelley Rankin; Fiscal Year: 2012
    ..AIMS The salmonellae are Gram negative, motile, non-spore forming bacilli which belong to the family Enterobacteriaceae. The genus Salmonella consists of only two species, Salmonella enterica and Salmonella bongori. S...
  22. Development of New Beta-Lactamase Inhibitors for Resistant Category B Food/Water-
    CHRISTOPHER JOHN BURNS; Fiscal Year: 2012
    ..However, the utility of this class of antibiotics in Enterobacteriaceae is compromised by the rapid spread of new (-lactamase resistance mechanisms, enzymes produced by bacteria ..
  23. Cell-Wall Recycling and Antibiotic Resistance
    Shahriar Mobashery; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Many members of Enterobacteriaceae and Pseudomonas aeruginosa (subject of this grant application) have the ability to sense damage inflicted to their cell wall by [unreadable]-lactam antibiotics...
  24. Phase II SBIR: Responding to NDM-1 - Advancement of a new MBL inhibitor to IND
    LUIGI XERRI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Multi-drug resistance in Enterobacteriaceae is regarded as a healthcare crisis...
  25. Drug Discovery from Slow Growing and Rare Microbial Species
    Amy Spoering; Fiscal Year: 2013
    ..aeruginosa, A. baumannii, ESBL and New Delhi metallo-b- lactamase-producing Enterobacteriaceae, and M. tuberculosis...
  26. Adherent Invasive E. coli and colitis
    ANDREAS J BAUMLER; Fiscal Year: 2013
    ..conditions of intestinal inflammation lead to an increased relative abundance of facultative anaerobic Enterobacteriaceae, such as Escherichia coli. Adherent- invasive E...
  27. Novel Antibacterials Targeting Gram-negative Nonfermenters
    Michelle M Butler; Fiscal Year: 2010
    ..compounds are also active against fastidious Gram- negative bacilli and a large number of strains from the Enterobacteriaceae family as well as a variety of Gram-positive bacterial species...
  28. Metagenomics guided pathogen discovery in Travelers'Diarrhea
    SARAH KATHERINE HIGHLANDER; Fiscal Year: 2013
    ..The list of prevalent TD pathogens is limited to less than ten bacterial genera (most of them in the family Enterobacteriaceae), several viruses, including norovirus, and a few protozoan parasites. Mixed infections are also prevalent...
  29. LIGAND RECEPTOR INTERACTIONS IN BACTERIAL ADHERENCE
    SOMAN ABRAHAM; Fiscal Year: 1993
    ..For this purpose the type 1 fimbria-medicated attached of Escherichia coli and other Enterobacteriaceae will be studied in detail as a paradigm of bacterial adhesion and colonization...
  30. Campylobacter jejuni and Reactive Nitrogen Species
    Nicole Iovine; Fiscal Year: 2007
    ..Despite this large burden of disease, little is known about the pathogenesis of C. jejuni compared to Enterobacteriaceae such as Salmonella...
  31. E COLI PATHOGENICITY ISLANDS
    RODNEY WELCH; Fiscal Year: 1999
    ..perform molecular epidemiological investigations of the new virulence genes among pathogenic members of the Enterobacteriaceae. The long term objective of the proposed project is to create a comprehensive data base of virulence genes ..
  32. CD4+ T CELLS RESPONDING TO SALMONELLA INFECTION
    Brad Cookson; Fiscal Year: 2005
    ..The other is an unidentified protein expressed by most Enterobacteriaceae, including E. coli, Yersinia, Shigella, and Enterobacter...
  33. Immune Reconstitution in Nonhuman Primates
    Thomas Macvittie; Fiscal Year: 2005
    ..Both E. coli and P. mirabilis are members of the Enterobacteriaceae, are motile, and produce a battery of fimbriae by which they mediate adherence to the uroepithelium...
  34. BACTERIAL INTERACTIONS WITH THE BLADDER MUCOSA
    Matthew Mulvey; Fiscal Year: 2002
    ..Other members of the Enterobacteriaceae family, including Klebsiella species and Proteus mitabilis, and Gram-positive organisms, including ..
  35. STUDY OF HOST-MICROBIAL FACTORS IN BACILLEMIA
    LOWELL YOUNG; Fiscal Year: 1980
    ..in principle, for quantitating 2 important bacillary antigens, the "Re" chemotype "core" glycolipid of Enterobacteriaceae and the K-1 antigen of E. coli...
  36. HG METABOLIZING BACTERIA IN SUBJECTS WITH DENTAL AMALGAM
    Anne Summers; Fiscal Year: 1990
    ..and organic mercury compounds are widely found in many facultative, enbacterial genera including the enterobacteriaceae, staphylococci, streptococci, and bacillaceae (Summers, 1986)...
  37. Ceftiofur use in cattle: a public health concern?
    Susan Sanchez; Fiscal Year: 2004
    ..use of ceftiofur in food animals is selecting for resistance to cephalosporins in members of the Family Enterobacteriaceae. Therefore, our short-term goal is to determine if the use of ceftiofur in sick cattle has resulted in ..
  38. Function and immunogenicity of Yersinia pestis fimbriae
    DIETER SCHIFFERLI; Fiscal Year: 2005
    ..pestis pathogenesis. The fimbrial proteins found in most if not all Enterobacteriaceae, including Y. pestis, are bestowed with such properties...
  39. MOLECULAR EVOLUTION OF ENTERIC BACTERIOCINS
    Margaret Riley; Fiscal Year: 2002
    ..distribution of bacteriocin production and resistance in one clinically relevant, division of bacteria, the Enterobacteriaceae. Novel bacteriocins will then be cloned and sequenced...
  40. Novel Therapeutics for Biodefense
    S Ken Tanaka; Fiscal Year: 2005
    ..particularly troublesome that the resistance determinants in the former are freely transmissible among other Enterobacteriaceae. SPECIFIC AIMS: Data from both animal models and human subjects have documented bona fide roles for members ..
  41. THERMOREGULATION OF SERUM-RESISTANCE IN S. TYPHIMURIUM
    JAMES VANDENBOSCH; Fiscal Year: 1991
    ..Since the thermoregulation of virulence traits is well established in other pathogenic Enterobacteriaceae, it is reasonable to assume that S. typhimurium may exhibit similar broad responses...
  42. THE CONTROL OF THE REPLICATION OF BACTERIAL EPISOMES
    ROBERT ROWND; Fiscal Year: 1980
    ..Most of our research is on the drug resistance plasmids (R plasmids) of the Enterobacteriaceae because of their importance to the health sciences and because of the remarkable mechanisms which R plasmids ..
  43. BIOSYNTHESIS OF ENTEROBACTERIAL COMMON ANTIGEN
    PAUL RICK; Fiscal Year: 2004
    ..ECA is an OM glycolipid that is unique to the Enterobacteriaceae, and it is present in all members of this family...
  44. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Jorge Velarde; Fiscal Year: 2004
    ..One of these is the Serine Protease Autotransporters of Enterobacteriaceae (SPATES)...
  45. NEW CONJUGATE VACCINE FOR GRAM NEGATIVE SEPSIS
    Gary Gustafson; Fiscal Year: 1999
    ..that elicits a strong anamnestic response eliciting protective antibodies to shared LPS epitopes in the Enterobacteriaceae family...
  46. ANTIBIOTIC RESISTANT BACILLI IN A NURSING HOME UNIT
    David Shlaes; Fiscal Year: 1990
    ..proposal is to examine prospectively the prevalence, mode of acquisition of urinary colonization with Enterobacteriaceae bearing multiple resistance determinants, their associated R plasmids and risk factors for such acquisition ..
  47. SEQUENCE ANALYSIS OF SALMONELLA GENOMES
    Richard Wilson; Fiscal Year: 1999
    ..of raw sequence (about 64 percent coverage) for six additional genomes from other members of the family, Enterobacteriaceae. While these genomes will not be sequenced to completion as part of this effort, the principal investigator ..
  48. Non-Invasive Approaches to Assessing Inflammation (RMI)
    RYAN SARTOR; Fiscal Year: 2006
    ..This project will create a new program involving investigators who have not previously worked together, while building on institutional strengths and programmatic initiatives. ..
  49. AUTOTRANSPORTERS OF ENTEROBACTERIACEAE
    James Nataro; Fiscal Year: 2008
    ..of a large groups of secreted gram negative virulence factors (the serine protease autotransporters of Enterobacteriaceae [SPATEs]), the characterization of the modes of action of at least two of these proteins, and the ..
  50. MECHANISMS AND CONSEQUENCES OF DELETERIOUS EVOLUTION IN BACTERIA
    Jennifer J Wernegreen; Fiscal Year: 2010
    ..By deciphering fundamental mechanisms that influence bacterial genome evolution, this study will contribute to a predictive framework for understanding how microbes evolve. ..
  51. Salmonella Gene Expression in Complex Environments
    Michael McClelland; Fiscal Year: 2004
    ..As a class, these methods should be applicable to studying gene expression in any bacterial or eukaryotic microbial community. ..
  52. Global Burden of Infectious Disease Through the GI Tract
    Pierre Payment; Fiscal Year: 2002
    ..The report will be broadly announced and made available through many popular and scientific media. ..
  53. A randomized trial of influenza vaccination of Hutterite children
    Mark Loeb; Fiscal Year: 2006
    ..We believe that the trial we propose will lead to important data that can inform policy on influenza immunization strategy. [unreadable] [unreadable] [unreadable]..
  54. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2009
    ..This research is designed to better understand how providers use information from various microbiology laboratory testing methods to choose treatments and to identify strategies that lead to the best patient outcomes. ..
  55. CHLAMYDIA PNEUMONIAE--A PATHOGEN IN ALZHEIMERS DISEASE
    Alan Hudson; Fiscal Year: 2002
    ..Such new information may well provide important new insights for development of novel therapeutic modalities to prevent or ameliorate late-onset AD. ..
  56. Antiretroviral Therapy of AIDS-Related Kaposi's Sarcoma in Africa
    Jeffrey Martin; Fiscal Year: 2009
    ..Findings from this work will both help to inform clinical care of patients with AIDS-related KS in Africa and provide biological insights into the effect of antiretroviral therapy on underlying KSHV infection. ..
  57. Comparative Genomics of Lyme Disease Spirochetes
    Sherwood Casjens; Fiscal Year: 2004
    ..burgdorferi population. These findings will impact the study of the molecular pathogenesis of Lyme disease in many ways. ..
  58. 2005 Antimicrobial Peptides Gordon Conference
    Andre Ouellette; Fiscal Year: 2005
    ..The organizational philosophy is to encourage diverse participation, and maintain an eye towards gender issues, junior scientists, minorities, and individuals with physical limitations. ..
  59. Innate Immunity to Salmonella Infections
    Joshua Fierer; Fiscal Year: 2005
    ..We will compare isogenic strains of salmonella that express either the group B or 0 LPS antigens in C3 deficient and neutropenic mice, in order to determine how the structure of the LPS affects virulence in mice. ..