gram negative aerobic bacteria

Summary

Summary: A large group of aerobic bacteria which show up as pink (negative) when treated by the gram-staining method. This is because the cell walls of gram-negative bacteria are low in peptidoglycan and thus have low affinity for violet stain and high affinity for the pink dye safranine.

Top Publications

  1. ncbi In vitro activity of gemifloxacin and contemporary oral antimicrobial agents against 27247 Gram-positive and Gram-negative aerobic isolates: a global surveillance study
    S K Bouchillon
    Laboratories International for Microbiology Studies, International Health Management Associates Inc, Schaumburg, IL, USA
    Int J Antimicrob Agents 23:181-96. 2004
  2. ncbi In vitro antimicrobial activity of gatifloxacin compared with other quinolones against clinical isolates from cancer patients
    Kenneth V I Rolston
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Chemotherapy 50:214-20. 2004
  3. ncbi [Bacteria isolated from surgical infections and its susceptibilities to antimicrobial agents--special references to bacteria isolated between April 2003 and March 2004]
    Nagao Shinagawa
    Department of Surgery, Nagoya Midori Municipal Hospital
    Jpn J Antibiot 58:123-58. 2005
  4. ncbi Five years of nosocomial Gram-negative bacteremia in a general intensive care unit: epidemiology, antimicrobial susceptibility patterns, and outcomes
    Wendy Sligl
    Division of Infectious Diseases, University of Alberta, WMC 2E4 16, 8440 112 Street, Edmonton, Canada T6G 2R7
    Int J Infect Dis 10:320-5. 2006
  5. ncbi [Bacteria isolated from surgical infections and its susceptibilities to antimicrobial agents--special references to bacteria isolated between April 2006 and March 2007]
    Nagao Shinagawa
    Department of Surgery, NTT West Tokai Hospital
    Jpn J Antibiot 61:122-71. 2008
  6. ncbi [Therapeutic management of peritonitis]
    A Bourgoin
    Departement d Anesthesie Reanimation, Hopital Nord, Chemin des Bourrelly, 13915 Marseille, France
    Med Mal Infect 34:183-95. 2004
  7. pmc Chromosomal integration of a cephalosporinase gene from Acinetobacter baumannii into Oligella urethralis as a source of acquired resistance to beta-lactams
    Hedi Mammeri
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 47:1536-42. 2003
  8. ncbi Impact of antimicrobial exposure and beta-lactamase-producing bacteria on salivary beta-lactamase activity in infancy
    S Nyfors
    Department of Microbiology, Anaerobe Reference Laboratory, National Public Health Institute KTL, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Int J Antimicrob Agents 24:463-7. 2004
  9. ncbi [Aminoglycosides]
    Julián Palomino
    Servicio de Enfermedades Infecciosas Hospital Universitario Virgen del Rocío Sevilla España
    Enferm Infecc Microbiol Clin 21:105-14; QUIZ 115, 120. 2003
  10. ncbi Ertapenem: no effect on aerobic gram-negative susceptibilities to imipenem
    Debra A Goff
    College of Pharmacy, The Ohio State University Medical Center, Department of Pharmacy, 410 West 10th Ave, 368 Doan Hall, Columbus, OH 43210, USA
    J Infect 57:123-7. 2008

Detail Information

Publications167 found, 100 shown here

  1. ncbi In vitro activity of gemifloxacin and contemporary oral antimicrobial agents against 27247 Gram-positive and Gram-negative aerobic isolates: a global surveillance study
    S K Bouchillon
    Laboratories International for Microbiology Studies, International Health Management Associates Inc, Schaumburg, IL, USA
    Int J Antimicrob Agents 23:181-96. 2004
    ..pneumoniae. Gemifloxacin MICs were more potent than grepafloxacin > levoflaxacin > ciproflaxin against the Gram-positive aerobes and shared comparable Gram-negative activity with ciprofloxacin and levofloxacin...
  2. ncbi In vitro antimicrobial activity of gatifloxacin compared with other quinolones against clinical isolates from cancer patients
    Kenneth V I Rolston
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Chemotherapy 50:214-20. 2004
    ..Stenotrophomonas maltophilia, Pseudomonas aeruginosa and other Pseudomonas species. Alcaligenes xylosoxidans strains were relatively resistant to all 4 agents...
  3. ncbi [Bacteria isolated from surgical infections and its susceptibilities to antimicrobial agents--special references to bacteria isolated between April 2003 and March 2004]
    Nagao Shinagawa
    Department of Surgery, Nagoya Midori Municipal Hospital
    Jpn J Antibiot 58:123-58. 2005
    ..coli producing extended spectrum beta-lactamase, but there was no highly cefazolin-resistant E. coli in this year. In the next series, increase of both anaerobic bacteria and Enterococcus spp. should be carefully followed up...
  4. ncbi Five years of nosocomial Gram-negative bacteremia in a general intensive care unit: epidemiology, antimicrobial susceptibility patterns, and outcomes
    Wendy Sligl
    Division of Infectious Diseases, University of Alberta, WMC 2E4 16, 8440 112 Street, Edmonton, Canada T6G 2R7
    Int J Infect Dis 10:320-5. 2006
    ..This study provides epidemiological and antimicrobial susceptibility data for nosocomial Gram-negative bacteremia in a general intensive care unit (ICU) over a five-year period...
  5. ncbi [Bacteria isolated from surgical infections and its susceptibilities to antimicrobial agents--special references to bacteria isolated between April 2006 and March 2007]
    Nagao Shinagawa
    Department of Surgery, NTT West Tokai Hospital
    Jpn J Antibiot 61:122-71. 2008
    ..aeruginosa. There were three strains of methicillin-resistant coagulase-negative Staphylococcus aureus, but all of them had good susceptibilities against various anti-MRSA antibiotics. We should carefully follow up B. wadsworthia...
  6. ncbi [Therapeutic management of peritonitis]
    A Bourgoin
    Departement d Anesthesie Reanimation, Hopital Nord, Chemin des Bourrelly, 13915 Marseille, France
    Med Mal Infect 34:183-95. 2004
    ..An antifungal treatment (fluconazole) is usually necessary, at least until the results of peritoneal fluid culture are available. The duration of treatment is quite variable, ranging from 48 h in less severe forms to 14 days...
  7. pmc Chromosomal integration of a cephalosporinase gene from Acinetobacter baumannii into Oligella urethralis as a source of acquired resistance to beta-lactams
    Hedi Mammeri
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 47:1536-42. 2003
    ..urethralis COH-1. This is one of the few examples of the interspecies transfer and the chromosomal integration of a gene encoding a naturally occurring beta-lactamase...
  8. ncbi Impact of antimicrobial exposure and beta-lactamase-producing bacteria on salivary beta-lactamase activity in infancy
    S Nyfors
    Department of Microbiology, Anaerobe Reference Laboratory, National Public Health Institute KTL, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Int J Antimicrob Agents 24:463-7. 2004
    ..08; CI 1.31-38.34). At 12 months, SbetaA was detected in 54% infants. Exposure to antimicrobials during the first year of life increased the risk (OR 2.60; CI 0.72-9.36) of having SbetaA...
  9. ncbi [Aminoglycosides]
    Julián Palomino
    Servicio de Enfermedades Infecciosas Hospital Universitario Virgen del Rocío Sevilla España
    Enferm Infecc Microbiol Clin 21:105-14; QUIZ 115, 120. 2003
    ..Among the adverse events, nephrotoxicity and ototoxicity require a careful evaluation during its administration...
  10. ncbi Ertapenem: no effect on aerobic gram-negative susceptibilities to imipenem
    Debra A Goff
    College of Pharmacy, The Ohio State University Medical Center, Department of Pharmacy, 410 West 10th Ave, 368 Doan Hall, Columbus, OH 43210, USA
    J Infect 57:123-7. 2008
    ..To describe any potential effect on in vitro susceptibility to imipenem for aerobic gram-negative bacteria following the addition of ertapenem to the formulary of a large teaching hospital...
  11. ncbi Antimicrobial resistance pattern among aerobic gram-negative bacilli of lower respiratory tract specimens of intensive care unit patients in a neurocentre
    H B Veena Kumari
    Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Indian J Chest Dis Allied Sci 49:19-22. 2007
    ....
  12. ncbi Etiology of ventilator-associated pneumonia
    Jordi Rello
    Critical Care Department, Joan XXIII University Hospital, University Rovira and Virgili, Carrer Dr Mallafre Guasch 4, Tarragona 43007, Spain
    Clin Chest Med 26:87-95. 2005
    ..The discussion herein analyzes these aspects, placing particular emphasis on risk factors, attributable mortality, resistance, and the implications for management...
  13. ncbi Factors affecting the bacteriology of deep neck infection: a retrospective study of 128 patients
    Tung Tsun Huang
    Department of Otolaryngology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    Acta Otolaryngol 126:396-401. 2006
    ..Anaerobic coverage is necessary, especially in odontogenic cases. The presence of diabetes, infection of the parotid space and an obvious odontogenic source of infection can aid in determining the causative organisms...
  14. ncbi Rifaximin: in vitro and in vivo antibacterial activity--a review
    Z D Jiang
    Center for Infectious Diseases, University of Texas Houston School of Public Health, Houston, TX 77030, USA
    Chemotherapy 51:67-72. 2005
    ..The available data suggest that rifaximin is active in vitro and in vivo in the treatment of bacterial infection of adults and children...
  15. ncbi Ertapenem: a new carbapenem
    I Odenholt
    Department of Infectious Diseases, University Hospital MAS, SE-205 02, Malmo, Sweden
    Expert Opin Investig Drugs 10:1157-66. 2001
    ..For anaerobic bacteria with MIC values between 1-2 mg/l, the T > MIC may not be sufficient for bacterial eradication. However, clinical trials have to confirm this hypothesis...
  16. ncbi Effect of bone biopsy in guiding antimicrobial therapy for osteomyelitis complicating open wounds
    G Khatri
    Department of Medicine, Medical College of Wisconsin, Milwaukee, USA
    Am J Med Sci 321:367-71. 2001
    ....
  17. ncbi [Bacteria isolated from surgical infections and its susceptibilities to antimicrobial agents--special references to bacteria isolated between April 2001 and March 2002]
    Nagao Shinagawa
    Department of Surgery, Nagoya Midori Municipal Hospital
    Jpn J Antibiot 56:105-37. 2003
    ..We noticed no vancomycin-resistant Gram-positive cocci...
  18. ncbi Antibiotic resistance in Burkina Faso
    G Bonfiglio
    Department of Microbiology, University of Catania, Italy
    New Microbiol 26:263-8. 2003
    ....
  19. ncbi Characterisation of and immunity to the aerobic bacteria found in the pouch of the brushtail possum Trichosurus vulpecula
    J E Deakin
    School of Biological Sciences, Macquarie University, 2109, Sydney, NSW, Australia
    Comp Immunol Microbiol Infect Dis 27:33-46. 2004
    ..In young over 70 days, antibody titres were significantly higher than those found in maternal serum, suggesting that the young is capable of producing adult type antibodies to pouch bacteria at this time...
  20. ncbi Bacteriologic characterization of 36 strains of Roseomonas species and proposal of Roseomonas mucosa sp nov and Roseomonas gilardii subsp rosea subsp nov
    Xiang Y Han
    Section of Clinical Microbiology, University of Texas M D Anderson Cancer Center, Unit 84, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Clin Pathol 120:256-64. 2003
    ..R mucosa strains were most resistant, whereas R gilardii subsp gilardii strains were most susceptible...
  21. pmc Comparison and evaluation of Osiris and Sirscan 2000 antimicrobial susceptibility systems in the clinical microbiology laboratory
    A Nijs
    Department of Clinical Laboratory, Virga Jesseziekenhuis, Stadsomvaart 11, B 3500 Hasselt, Belgium
    J Clin Microbiol 41:3627-30. 2003
    ..Overall, both the Osiris system and the Sirscan system are comparable and reliable systems for determination of interpretative categories from the zone diameters of standard disk diffusion test plates...
  22. ncbi Microbiology difference between colonized catheters and catheter-related bloodstream infections
    Che Lin
    Department of Surgery, National Taiwan University, Taipei, Taiwan
    Hepatogastroenterology 50:1821-4. 2003
    ..However, the actual incidence and bacterial pattern have not been well studied. This study was undertaken to investigate the difference in bacteriology between colonized catheters and catheter-related bloodstream infections...
  23. ncbi Development and characterization of an animal model of dental sinusitis
    K Garming Legert
    Department of Odontology, Karolinska Institutet, Huddinge, Sweden
    Acta Otolaryngol 125:1195-1202. 2005
    ..It is applicable to further studies of sinusitis of odontogenic origin...
  24. ncbi Prevalence and natural history of colonization with fluoroquinolone-resistant gram-negative bacilli in community-dwelling people with spinal cord dysfunction
    Mary Claire Roghmann
    VA Maryland Health Care System, University of Maryland School of Medicine, Baltimore, MD, USA
    Arch Phys Med Rehabil 87:1305-9. 2006
    ..To estimate the prevalence of colonization with fluoroquinolone-resistant gram-negative bacilli (GNB) and to assess risk factors for and define the natural history of colonization...
  25. ncbi [Comparison of clinical characteristics between cryptogenic and biliary pyogenic liver abscess]
    Hye Young Choi
    Department of Internal Medicine, Gangneung Asan Hospital, Ulsan University College of Medicine, Gangneung, Korea
    Korean J Gastroenterol 49:238-44. 2007
    ..The aim of this study was to evaluate the characteristics of cryptogenic and biliary pyogenic liver abscess by comparing the clinical aspects between the two groups...
  26. ncbi Display of proteins on bacteria
    Patrik Samuelson
    Division of Molecular Biotechnology, Department of Biotechnology, SCFAB, Royal Institute of Technology KTH, Roslagstullsbacken 21, SE 10691 Stockholm, Sweden
    J Biotechnol 96:129-54. 2002
    ..This article explains the basic principles of the different bacterial display systems, and discusses current uses and possible future trends of these emerging technologies...
  27. ncbi Iron transport and signaling in Escherichia coli
    Volkmar Braun
    Microbiology Membranephysiology, University of Tubingen, Auf der Morgenstelle 28, D 72076, Tubingen, Germany
    FEBS Lett 529:78-85. 2002
    ..Certain transport proteins also function in siderophore-mediated signaling cascades that start at the cell surface and flow to the cytoplasm to initiate transcription of genes encoding proteins for transport and siderophore biosynthesis...
  28. ncbi Supra-gingival microbiota in Sjögren's syndrome
    K C M Leung
    Oral Rehabilitation, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China
    Clin Oral Investig 11:415-23. 2007
    ..acidophilus and non-oral species, while SS sufferers generally had lower proportions of gram-negative species. The microbial composition of noncaries associated SGP indicates a potential source of increased caries risk in SS...
  29. ncbi [Changes in intestinal microflora following levofloxacin administration in laboratory animals]
    Filomena Ianniello
    Dipartimento do Malattie Infettive, Seconda Universita degli Studi di Napoli, Italy
    Infez Med 13:168-74. 2005
    ..Therefore, it may be suitable for selective decontamination of the gastrointestinal tract in immunocompromised patients, for prophylaxis of urinary tract infections and for treatment of intestinal bacterial infections...
  30. ncbi Endometriosis is associated with an altered profile of intestinal microflora in female rhesus monkeys
    Michael T Bailey
    University of Wisconsin, Harlow Center for Biological Psychology, 22 N Charter Street, Madison, WI 53715, USA
    Hum Reprod 17:1704-8. 2002
    ..A second study assessed the prevalence of intestinal inflammation in female monkeys to determine whether endometriosis is associated with an increased likelihood of intestinal inflammation...
  31. ncbi Synthetic dihydropacidamycin antibiotics: a modified spectrum of activity for the pacidamycin class
    Constantine G Boojamra
    Essential Therapeutics, Inc formerly Microcide Pharmaceuticals, Inc, 850 Maude Avenue, Mountain View, CA 94043, USA
    Bioorg Med Chem Lett 13:3305-9. 2003
    ..Some dihydropacidamycins are shown to have activity against multi-resistant clinical strains of Mycobacterium tuberculosis. Compounds of this class are inhibitors of the cell wall biosynthetic enzyme, MraY...
  32. ncbi Adaptation of sympatric Achromatium spp. to different redox conditions as a mechanism for coexistence of functionally similar sulphur bacteria
    Neil D Gray
    School of Civil Engineering and Geosciences, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK
    Environ Microbiol 6:669-77. 2004
    ..RY8 was more sensitive to sediment redox conditions than the other Achromatium species. Given the heterogeneous nature of sedimentary environments, redox-related niche differentiation may promote coexistence of sympatric Achromatium spp...
  33. ncbi Polyphasic identification of Bacillus and Brevibacillus strains from clinical, dairy and industrial specimens and proposal of Brevibacillus invocatus sp. nov
    N A Logan
    School of Biological and Biomedical Sciences, Glasgow Caledonian University, UK
    Int J Syst Evol Microbiol 52:953-66. 2002
    ....
  34. ncbi Isolation and structure determination of an antimicrobial ester from a marine sediment-derived bacterium
    Robert W Schumacher
    Department of Science, East Hampton High School, East Hampton, New York 11937 2537, USA
    J Nat Prod 66:1291-3. 2003
    ..Structure elucidation employed one- and two-dimensional NMR, HRFABMS, IR, and chemical analysis. Bonactin displayed antimicrobial activity against both Gram-positive and Gram-negative bacteria as well as antifungal activity...
  35. ncbi Polymicrobial bloodstream infections among children and adolescents with central venous catheters evaluated in ambulatory care
    Kevin J Downes
    Divisions of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Clin Infect Dis 46:387-94. 2008
    ..Bloodstream infections (BSIs) are an ever-present concern for clinicians evaluating ill-appearing pediatric patients with central venous catheters (CVCs) in the ambulatory care setting...
  36. ncbi Paenibacillus koleovorans sp. nov., able to grow on the sheath of Sphaerotilus natans
    Minoru Takeda
    Division of Materials Science and Chemical Engineering, Faculty of Engineering, Yokohama National University, Hodogaya, Japan
    Int J Syst Evol Microbiol 52:1597-601. 2002
    ..It is concluded that the two strains represent a novel Paenibacillus species, for which the name Paenibacillus koleovorans sp. nov. is proposed. The type strain is strain TB(T) (= JCM 11186T = IAM 14926T = KCTC 13912T)...
  37. ncbi Isolation and characterization of a fucoidan-degrading marine bacterium
    Takeshi Sakai
    Takara Bio Inc Biotechnology Research Laboratories, Seta, Shiga ken, Japan
    Mar Biotechnol (NY) 5:409-16. 2003
    ..okamuranus (44%), Nemacystus decipiens (19%), Laminaria japonica (31%), Kjellmaniella crassifolia (23%), sporophyl of Undaria pinnatifida (22%), Fucus vesiculosus (42%), and Ascophyllum nodosum (61%)...
  38. ncbi Removal of iron and manganese using biological roughing up flow filtration technology
    Virginia Alejandra Pacini
    Centro de Ingeniería Sanitaria, Facultad de Ciencias Exactas Ingenieria y Agrimensura, Universidad Nacional de Rosario Riobamba 245 Bis, 2000 Rosario, Argentina
    Water Res 39:4463-75. 2005
    ..This system combines simple, low-cost operation and maintenance with high iron and manganese removal efficiencies, thus constituting a technology which is particularly suited to small waterworks...
  39. ncbi A survey of filamentous organisms at the Deer Island treatment plant
    S Lee
    Louisiana Water Resources Research Institute, Louisiana State University, 3221 CEBA Building, Baton Rouge, LA 70803, USA
    Environ Technol 24:855-65. 2003
    ..No dominant filamentous species existed during the start-up period. Type 0803 and Type 1701, indicators of low oxygen level for the applied food to microorganism ratio, confirmed the low DO conditions of activated sludge tanks...
  40. ncbi Occurrence and role of lactic acid bacteria in seafood products
    Leroi Françoise
    Laboratoire de Science et Technologie de la Biomasse Marine, IFREMER, Rue de l Ile d Yeu, BP 21105, 44311 Nantes Cedex 03, France
    Food Microbiol 27:698-709. 2010
    ..Successful studies on LAB as probiotic for fish intensify, but this potential is still to be explored for human. Although not usual, some applications of LAB for fermentation of marine products and by-products are described...
  41. ncbi Specific spoilage organisms in breweries and laboratory media for their detection
    L Jespersen
    Royal Veterinary and Agricultural University, Department of Dairy and Food Science, Food Microbiology, Frederiksberg, Denmark
    Int J Food Microbiol 33:139-55. 1996
    ..process technology the importance of aerobic bacteria has decreased and the same applies for the Gram negative aerobic bacteria Hafnia protea and Enterobacter cloacae which are capable of surviving beer fermentation...
  42. ncbi In vitro potency of doripenem tested against an international collection of rarely isolated bacterial pathogens
    Ronald N Jones
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 63:434-9. 2009
    ..These results confirm the potential use of this new carbapenem for broad-spectrum empiric or directed antimicrobial therapy...
  43. ncbi Spontaneous bacterial peritonitis: pathogenesis, diagnosis, and management
    Sehmus Ozmen
    Department of Internal Medicine, Faculty of Medicine, University of Dicle, 21280 Diyarbakir, Turkey
    Acta Gastroenterol Belg 69:276-82. 2006
    ..Selective intestinal decontamination with 400 mg norfloxacin per day decreased the overall probability of recurrence from 68% to 20% in 1 year of follow-up...
  44. ncbi Antimicrobial therapy of febrile complications after high-dose chemo-/radiotherapy and autologous hematopoietic stem cell transplantation--guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)
    Hartmut Bertz
    Dept of Hematology and Oncology, University of Freiburg Medical Center Albert Ludwigs University Freiburg, Hugstetterstrasse 55, 79106, Freiburg, Germany
    Ann Hematol 82:S167-74. 2003
    ..Recombinant hematopoietic growth factors should not be added routinely but may be considered in life-threatening situations such as invasive pulmonary mycoses or sepsis...
  45. ncbi The role of quinolones in staphylococcal infection
    P M Shah
    Zentrum der Inneren Medizin, , Frankfurt am Main, FRG
    J Chemother 1:253-6. 1989
    ..Clinical experience (in the order of number of patients treated) has been gathered most extensively with ciprofloxacin, followed by pefloxacin, ofloxacin, norfloxacin, and enoxacin...
  46. ncbi Changing trends in bacteriology of peritonsillar abscess
    S B Megalamani
    Department of Ear, Nose and Throat, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India
    J Laryngol Otol 122:928-30. 2008
    ..To evaluate the type of aerobic bacteria commonly isolated from peritonsillar abscesses...
  47. ncbi Therapeutic efficacy of moxifloxacin, a new quinolone, in the treatment of experimental intra-abdominal abscesses induced by Bacteroides fragilis in mice
    Haragopal Thadepalli
    Charles Drew University of Medicine and Science, Los Angeles, Calif, and University of California, Irvine, Calif, USA
    Chemotherapy 50:76-80. 2004
    ..By virtue of its established efficacy on gram-negative aerobic bacteria and the observed in vivo efficacy on B. fragilis, moxifloxacin can be evaluated in the treatment of clinical anaerobic infections...
  48. ncbi Selective decontamination of the digestive tract: cumulating evidence, at last?
    Marc J M Bonten
    Department of Internal Medicine, Division of General Medicine, Infectious Diseases and Geriatrics, Eijkman Winkler Institute for Microbiology, Inflammation and Infectious Diseases, University Medical Centre Utrecht, The Netherlands
    Semin Respir Crit Care Med 27:18-22. 2006
    ..Additional studies are required to further define appropriate indications and limitations of this preventative strategy...
  49. ncbi An update on the synthesis and antibacterial effects of carbapenems
    Ahmed M Galal
    National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Recent Pat Antiinfect Drug Discov 5:23-43. 2010
    ..g., nosocomial pneumonia, septicemia, meningitis and cystic fibrosis. This article reviews patents claiming carbapenem antibacterial agents published from 2004-2008...
  50. ncbi Infectious complications after mass disasters: the Marmara earthquake experience
    Kenan Keven
    Department of Nephrology, Ankara University Medical School, Ibni Sina Hospital, Ankara, Turkey
    Scand J Infect Dis 35:110-3. 2003
    ..Infectious complications are common in renal victims of catastrophic earthquakes and are associated with increased mortality when complicated by sepsis...
  51. pmc Spontaneous bacterial peritonitis: How to deal with this life-threatening cirrhosis complication?
    Tarsila Cr Ribeiro
    Division of Gastroenterology, Department of Medicine of University Federal de São Paulo, UNIFESP, EPM, Sao Paulo, Sao Paulo, Brazil
    Ther Clin Risk Manag 4:919-25. 2008
    ..The recurrence rate of SBP is high and antibiotic prophylaxis has been recommended in high-risk settings. Unfortunately, the long-term prognosis remains poor...
  52. ncbi Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial
    Evert de Jonge
    Department of Intensive Care, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands
    Lancet 362:1011-6. 2003
    ..We assessed the effects of SDD on intensive-care-unit (ICU) and hospital mortality, and on the acquisition of resistant bacteria in adult patients admitted to intensive care...
  53. ncbi Antimicrobial activity of polycationic peptides
    A Giacometti
    Institute of Infectious Diseases and Public Health, University of Ancona, Italy
    Peptides 20:1265-73. 1999
    ..whereas magainin II exerted the highest anticryptococcal activity. Finally, the peptides showed high anti-Pneumocystis activity, whereas no compound had strong inhibitory effect on C. parvum...
  54. ncbi [Severe nosocomial infection of soft tissue in general surgery]
    I Vasile
    Clinica Chirurgie II, UMF Craiova
    Chirurgia (Bucur) 100:281-6. 2005
    ..We present the pathogenic, clinical and therapeutically problems which characterize this type of postoperative infections...
  55. pmc Antibiotic use during major head and neck surgery
    J T Johnson
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pennsylvania
    Ann Surg 207:108-11. 1988
    ..Perioperative antibiotic administration should be initiated prior to surgery. To date, no evidence exists to support prolonged administration of antibiotics beyond the first 24 hours following surgery...
  56. ncbi Influence of growth environment on coaggregation between freshwater biofilm bacteria
    A H Rickard
    School of Pharmacy, University of Manchester, Manchester, UK
    J Appl Microbiol 96:1367-73. 2004
    ..To characterize the expression of coaggregation between Blastomonas natatoria 2.1 and Micrococcus luteus 2.13 following growth in liquid culture, on agar and in an artificial biofilm matrix composed of poloxamer hydrogel...
  57. ncbi Modeling of chlorine effect on floc forming and filamentous micro-organisms of activated sludges
    Alejandro Caravelli
    Centro de Investigación y Desarrollo en Criotecnología de Alimentos CIDCA, Facultad de Ciencias Exactas UNLP CONICET, 47 y 116, La Plata 1900, Argentina
    Water Res 37:2097-105. 2003
    ..natans and 4.5 mgCl(2) (gVSS)(-1) for A. anitratus were obtained. These critical doses indicated that in non flocculated pure cultures, floc-former bacteria A. anitratus was more susceptible to chlorine action than S. natans...
  58. ncbi [Microbiology and management of gaseous gangrene:the Sichuan experience of 20 earthquake cases]
    Nan Jiang
    Department of Infectious Diseases, Sichuan Provincial People s Hospital, Chengdu 610072, China
    Zhonghua Nei Ke Za Zhi 47:715-7. 2008
    ..Gram-negative bacilli were slightly more common than other aerobic bacteria in gaseous gangrene wound, which was different from the findings of ordinary gaseous gangrene...
  59. ncbi Mechanism of plant growth promotion by rhizobacteria
    A Gupta
    Division of Microbiology, Indian Agricultural Research Institute, New Delhi 110 012, India
    Indian J Exp Biol 38:856-62. 2000
    ..In this review, we discuss the mechanisms by which plant growth promoting rhizobacteria may stimulate plant growth...
  60. pmc Manual and automated instrumentation for identification of Enterobacteriaceae and other aerobic gram-negative bacilli
    Caroline M O'Hara
    Division of Healthcare Quality Promotion, Centers for Disease Control, Atlanta, GA 30333, USA
    Clin Microbiol Rev 18:147-62. 2005
    ..Cost considerations introduce another variable into the equation affecting choice. Each system has its own strengths and weaknesses, and each laboratory must decide on the level of sophistication that fulfills its particular needs...
  61. ncbi [Effect of gas mixture component composition on the process of hard materials colonization by methanotrophic bacteria]
    A G Kisten'
    Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv
    Mikrobiol Z 64:67-74. 2002
    ..No essential differences have been registered under colonization of hydrophilic (glass) and hydrophobic (polysterene) materials by the both cultures...
  62. ncbi Screening of molecular repertoires by microbial surface display
    Thomas Jostock
    Technical University of Braunschweig, Institute of Biochemistry and Biotechnology, Spielmannstr 7, 38106 Braunschweig, Germany
    Comb Chem High Throughput Screen 8:127-33. 2005
    ..This review will focus on examples of microbial surface display used for the screening of combinatorial repertoires. Further, we discuss future opportunities and promising candidate proteins not yet employed for that task...
  63. ncbi The phylogenetic position and ultrastructure of the uncultured bacterium Achromatium oxaliferum
    I M Head
    Newcastle Research Group in Fossil Fuels and Environmental Geochemistry University of Newcastle upon Tyne, UK
    Microbiology 142:2341-54. 1996
    ..A. oxaliferum cells were confirmed as the source of the 16S rRNA sequence obtained, by the use of a fluorescently-labelled 16S rRNA-targeted oligonucleotide specific for the A. oxaliferum rRNA sequence...
  64. ncbi Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota
    M S Malo
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Gut 59:1476-84. 2010
    ..In this study the role of IAP in the preservation of the normal homeostasis of the gut microbiota was investigated...
  65. ncbi Correlation of in vitro activities of the fluoroquinolones to their in vivo efficacies
    P B Fernandes
    Anti infective Research, Abbott Laboratories, Abbott Park, IL 60064
    Drugs Exp Clin Res 14:375-8. 1988
    ..aeruginosa in this model. Differences in in vitro potencies were not reflected in in vivo efficacies.(ABSTRACT TRUNCATED AT 250 WORDS)..
  66. ncbi Experimental gentamicin nephrotoxicity and agents that modify it: a mini-review of recent research
    Badreldin H Ali
    Department of Pharmacology, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Oman
    Basic Clin Pharmacol Toxicol 109:225-32. 2011
    ..Most of the nephroprotective agents mentioned here have not been tested in large controlled clinical trials. Because of their relative safety and effectiveness, antioxidant agents seem to be good candidates for testing in humans...
  67. pmc Stability of cefazolin sodium in polypropylene syringes and polyvinylchloride minibags
    Ronald F Donnelly
    MSc Chem, BSc Pharm, is Product Development Pharmacist with the Department of Pharmaceutical Sciences, The Ottawa Hospital Civic Campus, Ottawa, Ontario
    Can J Hosp Pharm 64:241-5. 2011
    ..Cefazolin is a semisynthetic penicillin derivative with a narrow spectrum of activity covering some gram-positive organisms and a few gram-negative aerobic bacteria...
  68. ncbi Role of hydrogen peroxide in bactericidal action of catechin
    Hidetoshi Arakawa
    School of Pharmaceutical Sciences, Department of Analytical Chemistry, Showa University, Tokyo, Japan
    Biol Pharm Bull 27:277-81. 2004
    ..Therefore, hydrogen peroxide, which is generated by EGCg, appears to be involved in the bactericidal action of EGCg...
  69. ncbi [Antimicrobial effect of 4-(adamantyl-1)-1-(1-aminobutyl)benzol]
    N O Vrynchanu
    Mikrobiol Z 69:42-8. 2007
    ..newvcastle, Enterobacter aerogenes etc.) had maximal sensitivity (MIC 0.6-5.0 and 0.1-5.0 mg/ml, respectively). Pseudomonas aeruginosa were resistant to this substance (MIC >1 mg/ml)...
  70. ncbi Moxifloxacin penetration into human gastrointestinal tissues
    Martin Wirtz
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
    J Antimicrob Chemother 53:875-7. 2004
    ..The aim of the present study was to assess the penetration of moxifloxacin into gastrointestinal (GI) mucosal tissues to evaluate its potential role as an antimicrobial drug in bacterial infections of the GI tract...
  71. ncbi Synergistic activity of the novel des-fluoro(6) quinolone, garenoxacin (BMS-284756), in combination with other antimicrobial agents against Pseudomonas aeruginosa and related species
    J C Fung-Tomc
    Department of Microbiology, Bristol Myers Squibb Company, 5 Research Parkway, Wallingford, CT 06457, USA
    Int J Antimicrob Agents 20:57-60. 2002
    ..In conclusion, synergistic killing was observed frequently with GARX plus a non-quinolone bactericidal agents against non-fermentative Gram-negative bacteria, including strains intermediately susceptible/resistant to one or both agents...
  72. pmc In vitro susceptibility tests for cationic peptides: comparison of broth microdilution methods for bacteria that grow aerobically
    A Giacometti
    Institute of Infectious Diseases and Public Health, University of Ancona, Italy
    Antimicrob Agents Chemother 44:1694-6. 2000
    ..E. W. Hancock laboratory for testing antimicrobial peptides. Overall, the first method produced MICs two- and fourfold higher than the second method...
  73. ncbi Gut overgrowth with abnormal flora: the missing link in parenteral nutrition-related sepsis in surgical neonates
    H K F van Saene
    Department of Clinical Microbiology Infection Control, Royal Liverpool Children s NHS Trust, Alder Hey, Liverpool, UK
    Eur J Clin Nutr 57:548-53. 2003
    ..Gut overgrowth with aerobic Gram-negative bacilli (AGNB) impairs systemic immunity. The aim of this study was to determine the potential role of gut overgrowth with AGNB in the pathogenesis of septicaemia related to parenteral nutrition...
  74. ncbi Probiotic supplementation reduces the risk of bacterial translocation in experimental short bowel syndrome
    I Eizaguirre
    San Sebastian, Spain
    J Pediatr Surg 37:699-702. 2002
    ..The aim of this study was to test the hypothesis that BL administration decreases BT in SBS in animals fed orally...
  75. pmc Microbial growth on dichlorobiphenyls chlorinated on both rings as a sole carbon and energy source
    S Kim
    Environmental Science Research Center, School of Public and Environmental Affairs, Indiana University, Bloomington, IN 47405, USA
    Appl Environ Microbiol 67:1953-5. 2001
    ..Chlorobenzoates were not produced when strain SK-3 was grown on 2,4'-dichlorobiphenyl...
  76. ncbi The lipid A palmitoyltransferase PagP: molecular mechanisms and role in bacterial pathogenesis
    Russell E Bishop
    Departments of Laboratory Medicine and Pathobiology, and Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Mol Microbiol 57:900-12. 2005
    ..The PagP enzyme is potentially a target for the development of anti-infective agents, a probe of outer membrane lipid asymmetry, and a tool for the synthesis of lipid A-based vaccine adjuvants and endotoxin antagonists...
  77. ncbi Nuclear magnetic resonance studies of cesium-133 in the halophilic halotolerant bacterium Ba1. Chemical shift and transport studies
    A Sakhnini
    Department of Chemistry, Technion Israel Institute of Technology, Haifa, Israel
    NMR Biomed 11:80-6. 1998
    ..The first order constants for influx or efflux of cesium were from 2 x 10(-4) and up to 24 x 10(-4)/min for the different medium concentrations...
  78. ncbi Pharmacokinetics of polymyxin B1 in patients with multidrug-resistant Gram-negative bacterial infections
    Andrea L H Kwa
    Department of Pharmacy, Singapore General Hospital, Singapore 169608
    Diagn Microbiol Infect Dis 60:163-7. 2008
    ..The results of the series in conjunction with pharmacodynamic and susceptibility surveillance studies could facilitate an approach to the design of optimal dosing regimens...
  79. ncbi Septicaemia with probable endocarditis caused by Kingella denitrificans
    A M Brown
    Department of Medicine, Fazakerley Hospital, Liverpool, U K
    J Infect 15:225-8. 1987
    ..A 59-year-old man developed septicaemia caused by Kingella denitrificans. Treatment was with ampicillin and an aminoglycoside. The illness was complicated by a cerebral embolus. An obvious source of infection was not found...
  80. ncbi Piperacillin/tazobactam: an updated review of its use in the treatment of bacterial infections
    C M Perry
    Adis International Limited, Mairangi Bay, Auckland, New Zealand
    Drugs 57:805-43. 1999
    ..The incidence of adverse events with piperacillin/tazobactam is higher when the combination is given in combination with an aminoglycoside than when given as monotherapy...
  81. ncbi A novel replication element from an Antarctic plasmid as a tool for the expression of proteins at low temperature
    M L Tutino
    Dipartimento di Chimica Organica e Biochimica, , Italia
    Extremophiles 5:257-64. 2001
    ..haloplanktis A23 alpha-amylase in a psychrophilic bacterium. This study represents the first report of successful recombinant production of a cold-adapted protein in an Antarctic host...
  82. ncbi A set of positively regulated flagellar gene promoters in Caulobacter crescentus with sequence homology to the nif gene promoters of Klebsiella pneumoniae
    D Mullin
    Department of Molecular Biology, Princeton University, NJ 08544
    J Mol Biol 195:939-43. 1987
    ..We speculate that the conserved sequence elements mapping at -13, -24 and -100 are cis-acting regulatory elements required for the transcription and periodic regulation of these fla genes in the C. crescentus cell cycle...
  83. ncbi Proposal of Sphingomonas suberifaciens (van Bruggen, Jochimsen and Brown 1990) comb. nov., sphingomonas natatoria (Sly 1985) comb. nov., Sphingomonas ursincola (Yurkov et al. 1997) comb. nov., and emendation of the genus Sphingomonas
    E Yabuuchi
    Department of Microbiology and Immunology, Aichi Medical University, Japan
    Microbiol Immunol 43:339-49. 1999
    ..The type strain of S. suberifaciens is van Bruggen Cal=ATCC 49382=NCPPB 3629=IFO 15211=JCM 8521, that of S. natatoria is ATCC 35951 =DSM 3183=NCIMB 12085=JCM10396, and that of S. ursincola is DSM 9006= KR-99...
  84. pmc Gene cluster of Rhodothermus marinus high-potential iron-sulfur Protein: oxygen oxidoreductase, a caa(3)-type oxidase belonging to the superfamily of heme-copper oxidases
    M Santana
    , Universidade Nova de Lisboa, 2780-156 Oeiras, Portugal
    J Bacteriol 183:687-99. 2001
    ..The data are discussed in the framework of the evolution of oxidases within the superfamily of heme-copper oxidases...
  85. ncbi Mercuric reductase activity in the adaptation to cationic mercury, phenyl mercuric acetate and multiple antibiotics of a gram-negative population isolated from an aerobic fixed-bed reactor
    C Henriette
    Universite de Nancy 1, Laboratoire de Chimie Biologique 1, France
    J Appl Bacteriol 71:439-44. 1991
    ....
  86. ncbi Combination studies between polycationic peptides and clinically used antibiotics against Gram-positive and Gram-negative bacteria
    A Giacometti
    Department of Infectious Diseases, Institute of Infectious Diseases and Public Health, University of Ancona, I 60121 Ancona, Italy
    Peptides 21:1155-60. 2000
    ..The combination studies showed synergy between ranalexin and polymyxin E, doxycycline and clarithromycin. In addition, magainin II was shown to be synergic with betalactam antibiotics...
  87. ncbi A highly thermostable endo-(1,4)-beta-mannanase from the marine bacterium Rhodothermus marinus
    O Politz
    Department of Dermatology, Benjamin Franklin Medical Centre, The Free University of Berlin, Germany
    Appl Microbiol Biotechnol 53:715-21. 2000
    ..In contrast, R. marinus-derived protein retained 87% activity after 1 h at 90 degrees C. The enzyme hydrolysed carob-galactomannan (locust bean gum) effectively and to a smaller extent guar gum, but not yeast mannan...
  88. pmc Citromicrobium bathyomarinum, a novel aerobic bacterium isolated from deep-sea hydrothermal vent plume waters that contains photosynthetic pigment-protein complexes
    V V Yurkov
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Bacteriol 181:4517-25. 1999
    ..The taxonomic name Citromicrobium bathyomarinum (gen. nov., sp. nov.) is proposed for strain JF-1...
  89. ncbi The oral prevalence of aerobic and facultatively anaerobic gram-negative rods and yeasts in Hong Kong Chinese
    C M Sedgley
    Oral Biology Unit, Faculty of Dentistry, University of Hong Kong, Prince Philip Dental Hospital
    Arch Oral Biol 39:459-66. 1994
    ..05) and 15-29 yr (p < 0.05). Comparisons with previous studies suggest that the oral prevalence of AGNR in Chinese may be higher in Hong Kong than in other parts of the world...
  90. ncbi Imipenem resistance in nonfermenters causing nosocomial urinary tract infections
    N Taneja
    Department of Medical Microbiology, PGIMER, Chandigarh 160012, India
    Indian J Med Sci 57:294-9. 2003
    ..Piperacillin and amikacin had the best in vitro susceptibility. No significant difference was found in the antibiotic susceptibility profile among imipenem sensitive (S) or resistant (R) strains...
  91. ncbi The refined structure of the quinoprotein methanol dehydrogenase from Methylobacterium extorquens at 1.94 A
    M Ghosh
    Laboratory of Molecular Biophysics, University of Oxford, UK
    Structure 3:177-87. 1995
    ..Low-resolution structures of MDH have already been determined...
  92. ncbi [Susceptibility of clinical isolates from primary care clinics to oral antibacterial agents]
    Takaji Fujimura
    Discovery Research Laboratories, Shionogi and Co, Ltd
    Jpn J Antibiot 60:17-30. 2007
    ..aureus but a higher frequency of macrolide-resistant strains of Streptococcus pyogenes. Therefore, to accurately grasp susceptibility trends, well-focused surveillance studies are necessary...
  93. ncbi Cloning and expression of superoxide dismutase from Aquifex pyrophilus, a hyperthermophilic bacterium
    J H Lim
    Structural Biology Center, Korea Institute of Science and Technology, Cheongryang, Seoul
    FEBS Lett 406:142-6. 1997
    ..The metal binding residues found in all SOD sequences from different species are also conserved in A. pyrophilus SOD. The protein is biochemically active only as an oligomer and is resistant to thermal denaturation...
  94. pmc Purification and characterization of hydroxypyruvate reductase from the facultative methylotroph Methylobacterium extorquens AM1
    L V Chistoserdova
    W M Keck Laboratories, California Institute of Technology, Pasadena 91125
    J Bacteriol 173:7228-32. 1991
    ..Kinetics and inhibitory studies of the enzyme from M. extorquens AM1 suggest that hydroxypyruvate reductase is not a site for regulation of the serine cycle at the level of enzyme activity...
  95. ncbi Antagonistic activity against pathogenic bacteria by human vaginal lactobacilli
    Supayang Piyawan Voravuthikunchai
    Department of Microbiology, Faculty of Science, Prince of Songkla University, Hatyai, Songkla 90112, Thailand
    Anaerobe 12:221-6. 2006
    ..The antibacterial ability of the strain L 22 was fundamentally attributed to their bacteriocin production which can cause both cell inhibition and cell death...
  96. ncbi [Initial empirical antimicrobial therapy with piperacillin/tazobactam in intra-abdominal infections due to perforation of the large intestine and rectum and in postoperative complications after resection of the large intestine and rectum]
    F Vyhnanek
    Chirurgická klinika 3 LF UK Praha
    Rozhl Chir 81:617-21. 2002
    ....
  97. ncbi Purification and characterization of the complex I from the respiratory chain of Rhodothermus marinus
    Andreia S Fernandes
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
    J Bioenerg Biomembr 34:413-21. 2002
    ..At least five iron-sulfur centers are observed by EPR spectroscopy: two [2Fe-2S](2+/1+) and three [4Fe-4S](2+/1+) centers. By fluorescence spectroscopy a still unidentified chromophore was detected in R. marinus complex I...
  98. pmc Purification and characterization of chaperonins 60 and 10 from Methylobacillus glycogenes
    Y Kawata
    Department of Biotechnology, Faculty of Engineering, Tottori University, Japan
    Cell Stress Chaperones 3:200-7. 1998
    ..The similarities between the Escherichia coli GroE proteins are discussed...
  99. ncbi The changing pathogens of complicated parapneumonic effusions or empyemas in a medical intensive care unit
    Chih Yen Tu
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan
    Intensive Care Med 32:570-6. 2006
    ..To assess the incidence, pathogens, and outcome of complicated parapneumonic effusions or empyemas in a medical intensive care unit (MICU) patients with pleural effusions...
  100. ncbi Rhodothermus obamensis sp. nov., a modern lineage of extremely thermophilic marine bacteria
    Y Sako
    Department of Applied Bioscience, Graduate School of Agriculture, Kyoto University, Japan
    Int J Syst Bacteriol 46:1099-104. 1996
    ..On the basis of the physiological and molecular properties of the new isolate, we describe a new species, Rhodothermus obamensis. The type strain of R. obamensis is strain OKD7 (= JCM 9785)...
  101. pmc Characterization of active recombinant 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase from Comamonas testosteroni B-356 and sequence of the encoding gene (bphB)
    M Sylvestre
    Institut National de la Recherche Scientifique Santé, Universite du Quebec, Canada
    Appl Environ Microbiol 62:2710-5. 1996
    ..Compared with the cis-toluene dihydrodiol dehydrogenase, B2,3D appeared to be more substrate specific since it was unable to attack cis-1,2-dihydroxy-cyclohexa-3,5-diene...

Research Grants8

  1. A NOVEL THERAPY FOR RESPIRATORY SYNCYTIAL VIRUS
    Michelle Butler; Fiscal Year: 2003
    ..The goal is to file an IND within three years of initiation of the Phase I SBIR studies. ..
  2. DEVELOPMENT OF SCREENS FOR BACILLUS ANTHRACIS TARGETS
    Michelle Butler; Fiscal Year: 2005
    ..In Phase II, we will optimize the most promising compounds to develop novel leads and candidate drugs for pre-clinical testing in animal models of infection. ..
  3. BACTERIAL DNA POLYMERASES: TARGET FOR NOVEL ANTIBIOTICS
    Michelle Butler; Fiscal Year: 2005
    ..The SAR development and in vitro and in vivo characterization studies are the subject of this Phase II application. ..
  4. DEVELOPMENT OF INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS DNA REPLICATION
    Michelle Butler; Fiscal Year: 2007
    ..In Phase II, we will optimize the most promising compounds to develop novel leads and candidate drugs for pre-clinical testing in animal models of infection. [unreadable] [unreadable] [unreadable]..
  5. Microbial metabolism of aliphatic alkenes & epoxides
    SCOTT ENSIGN; Fiscal Year: 2008
    ..We intend to further our work on the central roles of carboxylation and novel cofactors/enzymes in bacterial hydrocarbon/epoxide/ketone metabolism by pursuing the biochemical, structural, and genetic characterization of these processes. ..
  6. Bacterial DnaA Initiator Protein: A Target for Novel Antibiotics
    Michelle Butler; Fiscal Year: 2008
    ..This proposal describes a new type of screening assay that can identify inhibitors of DnaA, a previously unexploited protein involved in the initiation of DNA synthesis. [unreadable] [unreadable] [unreadable]..
  7. Selectable biomarkers for pathogenic Burkholderia
    WILLIAM HICKEY; Fiscal Year: 2008
    ..Third, the marker could be used alone, or in combination with other markers, which could provide greater flexibility in molecular genetics studies. [unreadable] [unreadable] [unreadable]..
  8. Impact of Social Stress on TLR4-Induced Microbicidal Activity of CD11b+ Cells
    Michael Bailey; Fiscal Year: 2008
    ..Defining the stress-induced cellular changes that enhance immune functioning could stimulate new therapeutic approaches to treating infectious diseases. [unreadable] [unreadable] [unreadable] [unreadable]..