Genomes and Genes
Summary: A species of CHLAMYDOPHILA that causes acute respiratory infection, especially atypical pneumonia, in humans, horses, and koalas.
Publications247 found, 100 shown here
- Differential involvement of TLR2 and TLR4 in host survival during pulmonary infection with Chlamydia pneumoniaeNuria Rodriguez
Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany
Eur J Immunol 36:1145-55. 2006..All TLR2(-/-) x TLR4(d/d) mice succumbed to the infection, while about 50% of TLR2(-/-) mice died. Taken together, the function of TLR2 and TLR4 is required to survive pulmonary infection with C. pneumoniae...
- Possibilities for therapeutic interventions in disrupting Chlamydophila pneumoniae involvement in atherosclerosisJustin F Deniset
Department of Physiology, Faculties of Medicine and Pharmacy, Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada
Fundam Clin Pharmacol 24:607-17. 2010Strong sero-epidemiologic, pathologic, and experimental evidence suggests that Chlamydophila pneumoniae (Cpn) infection may play a causative role in the development of atherosclerosis...
- Chlamydophila pneumoniae phospholipase D (CpPLD) drives Th17 inflammation in human atherosclerosisMarisa Benagiano
Patologia Medica, Azienda Ospedaliero Universitaria Careggi Firenze, 50134 Florence, Italy
Proc Natl Acad Sci U S A 109:1222-7. 2012..Here, we investigated the role of the innate and acquired immune responses elicited by Chlamydophila pneumoniae phospholipase D (CpPLD) in the pathogenesis of atherosclerosis...
- Chlamydophila pneumoniaeF Blasi
Institute of Respiratory Diseases, University of Milan, IRCCS Fondazione Ospedale Maggiore, Milan, Italy
Clin Microbiol Infect 15:29-35. 2009b>Chlamydophila pneumoniae infection is ubiquitous. It accounts for 10% of community-acquired pneumonias and 5% of cases of pharyngitis, bronchitis and sinusitis in both immunocompetent and immunocompromised hosts...
- Nod1-mediated endothelial cell activation by Chlamydophila pneumoniaeBastian Opitz
Department of Internal Medicine Infectious Diseases, Charite University Medicine Berlin, Berlin, Germany
Circ Res 96:319-26. 2005..and animal studies, as well as demonstration of viable bacteria in atherosclerotic plaques, have linked Chlamydophila pneumoniae infection to development of chronic vascular lesions and coronary heart disease...
- Chlamydia pneumoniae--an infectious risk factor for atherosclerosis?Lee Ann Campbell
Department of Pathobiology, Box 357238, University of Washington, Seattle, Washington 98155, USA
Nat Rev Microbiol 2:23-32. 2004..This review focuses on the accumulating evidence that chronic infection with Chlamydia pneumoniae, a ubiquitous human respiratory pathogen, might contribute to atherosclerotic lesion progression...
- Chlamydophila pneumoniaeAlmudena Burillo
Clinical Microbiology Department, Hospital Universitario de Móstoles, C Río Júcar, S N, 28935 Móstoles, Madrid, Spain
Infect Dis Clin North Am 24:61-71. 2010b>Chlamydophila pneumoniae is estimated to cause about 10% of community-acquired pneumonia (CAP) cases and 5% of bronchitis cases, although most patients with C pneumoniae infection are asymptomatic, and the course of respiratory illness is ..
- Induction of proinflammatory cytokines in human osteoblastic cells by Chlamydia pneumoniaeAntonietta Rizzo
Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, Faculty of Medicine and Surgery Second University of Naples, Naples, Italy
Cytokine 56:450-7. 2011..pneumoniae. Thus, controlling the release of chemokines, e.g., IL-23, may be a therapeutic strategy for preventing inflammatory bone disease and counteract inflammation and bone destruction...
- Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infectionKenichi Shimada
Division of Pediatrics Infectious Disease and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America
PLoS ONE 6:e21477. 2011..Interestingly, Caspase-1 activation during CP infection occurs with mitochondrial dysfunction indicating a possible mechanism involving the mitochondria for CP-induced inflammasome activation...
- Prevalence of Chlamydophila pneumoniae is higher in aorta and coronary artery than in carotid artery of coronary artery disease patientsHem C Jha
Institute of Pathology, ICMR, Safdarjung Hospital Campus, New Delhi, India
APMIS 117:905-11. 2009..Data obtained from several seroepidemiological studies have suggested that infection with Chlamydophila pneumoniae, Helicobacter pylori, cytomegalovirus and herpes simplex virus-1 can initiate or maintain the ..
- Detection of Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella spp. in clinical specimens using a single-tube multiplex real-time PCR assayKathleen A Thurman
Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Diagn Microbiol Infect Dis 70:1-9. 2011..This procedure may allow for a practical and efficient means to test respiratory clinical specimens for atypical pneumonia agents in health care settings and facilitate an appropriate public health response to outbreaks...
- Chlamydia pneumoniae GroEL1 protein is cell surface associated and required for infection of HEp-2 cellsFrederik N Wuppermann
Funktionelle Genomforschung der Mikroorganismen, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, Geb 25 02 U1, 40225 Dusseldorf, Germany
J Bacteriol 190:3757-67. 2008..pneumoniae, although adhesion of infectious bacteria to eukaryotic cells was not affected. Taken together, these data support a role for extracellular GroEL1 in the establishment of the chlamydial infection...
- Chlamydia pneumoniae--induced macrophage foam cell formation is mediated by Toll-like receptor 2Fei Cao
Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Infect Immun 75:753-9. 2007..pneumoniae, Pam, and E. coli LPS). Overall, our results suggest that activation of the LXR signaling pathway may affect potentially atherogenic processes modulated by the TLR ligands...
- The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infectionKenichi Shimada
Division of Pediatrics, Infectious Diseases, and Immunology, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
PLoS Pathog 5:e1000379. 2009Here we investigated the role of the Nod/Rip2 pathway in host responses to Chlamydophila pneumoniae-induced pneumonia in mice. Rip2(-/-) mice infected with C...
- Prospective study of pathogen burden and risk of myocardial infarction or deathJ Zhu
Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC 20010, USA
Circulation 103:45-51. 2001..CONCLUSIONS: The results suggest that infection plays an important role in incident MI or death and that the risk posed by infection is independently related to the pathogen burden...
- Role of atypical bacterial infection of the lung in predisposition/protection of asthmaPhilip M Hansbro
Discipline of Immunology and Microbiology, School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales, Australia
Pharmacol Ther 101:193-210. 2004....
- Multiple infections and subsequent cardiovascular events in the Heart Outcomes Prevention Evaluation (HOPE) StudyMarek Smieja
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Circulation 107:251-7. 2003....
- Chlamydia pneumoniae in asymptomatic carotid atherosclerosisR Sessa
Department of Public Health Sciences, La Sapienza University, Piazzale Aldo Moro 5, 00185 Rome, Italy
Int J Immunopathol Pharmacol 19:111-8. 2006..In conclusion, our results suggest that the detection of C. pneumoniae DNA in PBMC specimens seems to be a first-choice method to identify the patients at risk for endovascular chlamydial infection...
- Resveratrol and curcumin reduce the respiratory burst of Chlamydia-primed THP-1 cellsGinette Deby-Dupont
Center for Oxygen, Research and Development CORD, Institut de Chimie, B6a, University of Liege, Sart Tilman, Belgium
Biochem Biophys Res Commun 333:21-7. 2005..Quercetin was inactive, and rutin a moderate but significant inhibitor. The inhibition by resveratrol was increased by 10(-6) M rutin or quercetin. Resveratrol and curcumin thus appeared to be interesting for atherosclerosis treatment...
- Oxidized LDL promotes the mitogenic actions of Chlamydia pneumoniae in vascular smooth muscle cellsMirna N Chahine
Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, 351 Tache Ave, Winnipeg, Manitoba, Canada R2H 2A6
Cardiovasc Res 92:476-83. 2011..pneumoniae in vascular smooth muscle cells (VSMCs) and the involvement of mitogen-activated protein kinase (MAPK) pathways and heat shock protein 60 (HSP60) in these mechanisms...
- Induced expression of lectin-like oxidized ldl receptor-1 in vascular smooth muscle cells following Chlamydia pneumoniae infection and its down-regulation by fluvastatinD Prochnau
Department of Internal Medicine Cardiology, Friedrich Schiller University of Jena, Jena, Germany
Acta Microbiol Immunol Hung 57:147-55. 2010..pneumoniae infection and atherosclerosis. The effect of lowering the LOX-1 expression by fluvastatin may provide a pharmacological option of limiting oxLDL uptake via its scavenger receptor...
- Measurement of Chlamydia pneumoniae bacterial load in peripheral blood mononuclear cells may be helpful to assess the state of chlamydial infection in patients with carotid atherosclerotic diseaseRosa Sessa
Department of Public Health Sciences, Sapienza University, P le Aldo Moro, 5 00185 Rome, Italy
Atherosclerosis 195:e224-30. 2007..We investigated the pattern of distribution of C. pneumoniae among patients with carotid atherosclerotic disease evaluating chlamydial load in carotid plaque, peripheral blood mononuclear cells (PBMC) and lymph node from same patient...
- GroEL1, a heat shock protein 60 of Chlamydia pneumoniae, induces lectin-like oxidized low-density lipoprotein receptor 1 expression in endothelial cells and enhances atherogenesis in hypercholesterolemic rabbitsFeng Yen Lin
Division of Cardiology, Taipei Medical University Hospital, Taipei 110, Taiwan
J Immunol 186:4405-14. 2011..The GroEL1 protein of C. pneumoniae may contribute to vascular inflammation and cardiovascular disorders...
- Endovascular presence of Chlamydia pneumoniae DNA is a generalized phenomenon in atherosclerotic vascular diseaseM Maass
Institute of Medical Microbiology, Medical University of Lubeck, Germany
Atherosclerosis 140:S25-30. 1998..However, it remains unclear whether chlamydia actually initiates atherosclerotic injury, facilitates its progression, or merely colonizes pre-existing atheromata...
- Detailed protocol for purification of Chlamydia pneumoniae elementary bodiesSanghamitra Mukhopadhyay
Division of Infectious Diseases, Department of Medicine, Rm 311 B Building, 500 South Preston St, University of Louisville School of Medicine, Louisville, KY 40292, USA
J Clin Microbiol 42:3288-90. 2004..A detailed protocol for the growth and harvest of purified elementary bodies of Chlamydia pneumoniae is presented. This procedure utilizes a flask-to-flask passage scheme designed to achieve high bacterial titers in a short period of time...
- Chlamydia pneumoniae and lung cancer: epidemiologic evidenceAlyson J Littman
Department of Epidemiology, University of Washington, Seattle, Washington, USA
Cancer Epidemiol Biomarkers Prev 14:773-8. 2005..g., studies that involve detection of C. pneumoniae in pulmonary specimens obtained before cancer onset) could be explored and may shed additional light on this important association...
- Antibiotics for the secondary prevention of ischemic heart disease: a meta-analysis of randomized controlled trialsBrian J Wells
Department of Family Medicine, Medical University of South Carolina, Charleston, SC 29245, USA
Arch Intern Med 164:2156-61. 2004..The numerous clinical trials that have studied the use of antibiotics in the secondary prevention of IHD have had conflicting results...
- Detection of Chlamydophila pneumoniae (Chlamydia pneumoniae) in endarteroctomy specimens of coronary heart diseases patientsGita Satpathy
Dr RP Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
Indian J Med Res 128:658-62. 2008..pneumoniae, its antigen or genome in the diseased arterial tissue. This study was thus conducted to look for antigen or genome of C. pneumoniae in coronary artery specimens from patients with coronary artery disease along with serology...
- A protein secreted by the respiratory pathogen Chlamydia pneumoniae impairs IL-17 signalling via interaction with human Act1Katerina Wolf
Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
Cell Microbiol 11:769-79. 2009..We describe here a unique strategy employed by C. pneumoniae to achieve inhibition of NFκB activation via interaction of CP0236 with mammalian Act1...
- Expression of chemokines and adhesion molecules in human coronary artery endothelial cells infected with Chlamydia (Chlamydophila) pneumoniaeM Högdahl
Department of Clinical Microbiology, University Hospital, Linkoping, Sweden
APMIS 116:1082-8. 2008..This suggests that C. pneumoniae initiates and propagates vascular inflammation in ways that contribute to coronary artery disease...
- Chlamydia pneumoniae infection and lung cancer risk: a meta-analysisPing Zhan
First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
Eur J Cancer 47:742-7. 2011..22; 95% CI, 1.06-1.41) and the IgA ≥ 64 cutoff group (OR, 2.35; 95% CI, 1.88-2.93). In conclusion, C. pneumoniae infection is associated with an increased risk for lung cancer, higher titre may be a better predictor of lung cancer risk...
- TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosisYoshikazu Naiki
Division of Pediatric Infectious Diseases, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, CA 90048, USA
J Immunol 181:7176-85. 2008..pneumoniae infection...
- Lack of Chlamydophila pneumoniae and predominance of Alloiococcus otitidis in middle ear fluids of children with otitis media with effusionMelih Guven Guvenc
Istanbul Bilim University, Medical Faculty, Department of Otorhinolaryngology, Turkey
Auris Nasus Larynx 37:269-73. 2010To investigate the presence of Chlamydophila pneumoniae and other bacterial pathogens in middle ear effusion samples obtained from children with otitis media with effusion (OME).
- Increased aortic intima-media thickness in 11-year-old healthy children with persistent Chlamydia pneumoniae seropositivityIina Volanen
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
Arterioscler Thromb Vasc Biol 26:649-55. 2006..Because atherogenesis begins in early life, we examined whether carotid and aortic intima-media thickness (IMT) and brachial artery endothelial function are associated with Cpn seropositivity in children...
- Do pathogens accelerate atherosclerosis?D N Streblow
Department of Molecular Microbiology and Immunology and The Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Portland OR 97201, USA
J Nutr 131:2798S-2804S. 2001..Because SMC migration into the neointimal space is the hallmark of vascular disease, these observations provide a molecular link between HCMV and the development of vascular disease...
- Airflow limitation, asthma, and Chlamydia pneumoniae-specific heat shock protein 60David L Hahn
Department of Family Practice, Dean Medical Center, Madison, Wisconsin, USA
Ann Allergy Asthma Immunol 101:614-8. 2008..The pathogenesis of C trachomatis disease associations is thought to include molecular mimicry (autoimmunity), direct activation of the innate immune response via the CD14/toll-like receptor 4 complex, or both...
- Predominant role of toll-like receptor 2 versus 4 in Chlamydia pneumoniae-induced activation of dendritic cellsS Prebeck
Institutes of. Medical Microbiology, Immunology, and Hygiene, and Clinical Chemistry and Pathobiochemistry, Technical University of Munich, Munich, Germany
J Immunol 167:3316-23. 2001..In conclusion, we show here that recognition of the Gram-negative bacterium C. pneumoniae depends largely on TLR2 and only to a minor extent on TLR4...
- Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathwaysMihai G Netea
Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
Eur J Immunol 32:1188-95. 2002..pneumoniae stimulates cytokine production in a serum-dependent manner, but independently of complement, MBL and LBP. C. pneumoniae induces the pro-inflammatory cytokines TNF and IL-1beta through TLR2, but not TLR4 and CD14...
- Chlamydia pneumoniae infection and risk of lung cancerAlyson J Littman
Department of Epidemiology, University of Washington, 1100 Fairview Avenue North, PO Box 19024, Seattle 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 13:1624-30. 2004..Future studies using precise measures of chronic C. pneumoniae status are needed to better determine the role of this organism in the etiology of lung cancer...
- Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activationShuang Chen
Division of Pediatric Infectious Diseases and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, CA 90048, USA
J Immunol 181:7186-93. 2008..pneumoniae accelerates the development of atherosclerotic plaque and lends support to the proposal that LXR agonists might prove clinically useful in suppressing atherogenesis...
- Occurrence of Chlamydia trachomatis and Chlamydia pneumoniae in paediatric respiratory infectionsW C Webley
University of Massachusetts, Dept of Microbiology, Morrill Science Center IVN Rm 203, Amherst, MA 01003, USA
Eur Respir J 33:360-7. 2009..To the current authors' knowledge, this is the first report of viable Chlamydia trachomatis in the lungs of children...
- Chronic Chlamydophila pneumoniae infection in lung cancer, a risk factor: a case-control studyBekir Kocazeybek
Cerrahpasa Faculty of Medicine, Istanbul University, Department of Microbiology and Clinical Microbiology, Istanbul, Turkey
J Med Microbiol 52:721-6. 2003..The values between IgG >/= 512 and IgA >/= 40 were set as the criteria for chronic Chlamydophila pneumoniae infections...
- Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasomeXianbao He
Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
J Immunol 184:5743-54. 2010..pneumoniae directly activates the NLRP3/ASC inflammasome, leading to the release of biologically active IL-1beta, and that concurrent IL-1 signaling is required for optimal host defense against acute bacterial pneumonia...
- Multipathogen infections in hospitalized children with acute respiratory infectionsDan Peng
Pediatrics Department, Zhongnan Hospital, Wuhan University, Wuhan 430071, PR China
Virol J 6:155. 2009..A medical history of each child was taken...
- Essential role of mitochondrial antiviral signaling, IFN regulatory factor (IRF)3, and IRF7 in Chlamydophila pneumoniae-mediated IFN-beta response and control of bacterial replication in human endothelial cellsClaudia Buss
Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
J Immunol 184:3072-8. 2010b>Chlamydophila pneumoniae infection of the vascular wall as well as activation of the transcription factor IFN regulatory factor (IRF)3 have been linked to development of chronic vascular lesions and atherosclerosis...
- Inhibition of apoptosis in neuronal cells infected with Chlamydophila (Chlamydia) pneumoniaeDenah M Appelt
Department of Neuroscience, Physiology and Pharmacology, Philadelphia College of Osteopathic Medicine, Philadelphia, USA
BMC Neurosci 9:13. 2008..Chronic and/or persistent infection of neuronal cells with C. pneumoniae in the AD brain may affect apoptosis in cells containing chlamydial inclusions...
- Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified miceM E Rottenberg
Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden
J Immunol 162:2829-36. 1999..pneumoniae. The higher sensitivity of IFN-gammaR-/- mice to C. pneumoniae compared with that of SCID or recombination-activating gene-1-/- mice suggested a relevant protective role of IFN-gamma-dependent innate mechanisms of protection...
- Infectious Chlamydia pneumoniae is associated with elevated interleukin-8 and airway neutrophilia in children with refractory asthmaKatir K Patel
Department of Microbiology, University of Massachusetts Amherst Massachusetts, Amherst, MA 01003, USA
Pediatr Infect Dis J 29:1093-8. 2010..Chlamydia pneumoniae has been implicated in asthma, possibly by induction of interleukin (IL-8). We hypothesized that IL-8 is increased in the bronchoalveolar lavage (BAL) fluid from children with asthma and C. pneumoniae...
- Isolation and continuous growth of Chlamydia pneumoniae from arterectomy specimensP Apfalter
Department of Clinical Microbiology, Hygiene Institute, University of Vienna, Austria
Eur J Clin Microbiol Infect Dis 19:305-8. 2000..Thus, viable Chlamydia pneumoniae strains are also present in vascular regions other than those hitherto described...
- Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitizationNicolas W J Schröder
Pediatric Infectious Diseases, Cedars Sinai Medical Center, University of California, Los Angeles, CA, USA
J Allergy Clin Immunol 122:595-602.e5. 2008..A mechanistic reconciliation of these findings has not yet emerged. In particular, the role of innate immunity in this context is unclear...
- Chronic infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus: population based study of coronary heart diseaseJ Danesh
Clinical Trial Service Unit and Epidemiological Studies Unit, Radcliffe Infirmary, Oxford OX2 6HE, UK
Heart 81:245-7. 1999..To study possible associations between coronary heart disease and serological evidence of persistent infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus...
- Detection of Mycoplasma pneumoniae in the airways of adults with chronic asthmaM Kraft
Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colorado, USA
Am J Respir Crit Care Med 158:998-1001. 1998..pneumoniae (p = 0.05). M. pneumoniae was present in the lower airways of chronic, stable asthmatics with greater frequency than control subjects, and may play a role in the pathogenesis of chronic asthma...
- Design of a multiplex PCR for Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae and Chlamydophila pneumoniae to be used on sputum samplesKristoffer Stralin
Department of Infectious Diseases, Orebro University Hospital, Orebro, Sweden
APMIS 113:99-111. 2005..simultaneous detection of specific genes for Streptococcus pneumoniae (lytA), Mycoplasma pneumoniae (P1), Chlamydophila pneumoniae (ompA), and Haemophilus influenzae (16S rRNA, with verification PCR for P6)...
- Application of a Mycoplasma group-specific PCR for monitoring decontamination of Mycoplasma-infected Chlamydia sp. strainsJ M Ossewaarde
Research Laboratory for Infectious Diseases, National Institute of Public Health and Environmental Hygiene, Bilthoven, The Netherlands
Appl Environ Microbiol 62:328-31. 1996..pneumoniae strains from clinical specimens...
- Chlamydia pneumoniae infection accelerates hyperlipidemia induced atherosclerotic lesion development in C57BL/6J miceE Blessing
Department of Pathobiology, University of Washington, Box 357238, Seattle, WA 98195, USA
Atherosclerosis 158:13-7. 2001..02). This study shows that chronic C. pneumoniae infection accelerates atherosclerotic lesion development in diet induced hypercholesterolemic mice, indicating that C. pneumoniae is a co-risk factor of hyperlipidemia in atherogenesis...
- Age alterations in extent and severity of experimental intranasal infection with Chlamydophila pneumoniae in BALB/c miceC Scott Little
Department of Pathology, Microbiology, and Immunology, the Philadelphia College of Osteopathic Medicine, 4170 City Ave, Philadelphia, PA 19131, USA
Infect Immun 73:1723-34. 2005..pneumoniae titers in old animals than in young animals. Our results suggest that infection with C. pneumoniae may be more severe in old animals...
- The association of seropositivity to Helicobacter pylori, Chlamydia pneumoniae, and cytomegalovirus with risk of cardiovascular disease: a prospective studyAgha W Haider
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
J Am Coll Cardiol 40:1408-13. 2002..We sought to determine whether seropositivity to Helicobacter pylori, Chlamydia pneumoniae, and cytomegalovirus (CMV) is an independent predictor of incident cardiovascular disease...
- Higher incidence of persistent chronic infection of Chlamydia pneumoniae among coronary artery disease patients in India is a cause of concernHem C Jha
Division of Tissue Culture Microbiology, Institute of Pathology ICMR, Safdarjung Hospital Campus, New Delhi, India
BMC Infect Dis 7:48. 2007..This will help in order to prepare strategies for the antibiotic intervention to avoid the progression towards CAD...
- Development and evaluation of Chlamylege, a new commercial test allowing simultaneous detection and identification of Legionella, Chlamydophila pneumoniae, and Mycoplasma pneumoniae in clinical respiratory specimens by multiplex PCRC Ginevra
Laboratoire de Bacteriologie virologie, GIMAP, Faculte de Medecine Jacques Lisfranc, Saint Etienne, France
J Clin Microbiol 43:3247-54. 2005..which allows the simultaneous detection in respiratory samples of Chlamydophila pneumoniae, Mycoplasma pneumoniae, and most Legionella species, as well as PCR inhibitors, by using a multiplex PCR ..
- Amphiphysin IIm is required for survival of Chlamydia pneumoniae in macrophagesElizabeth S Gold
Institute for Systems Biology, 1441 N 34th St, Seattle, WA 98103, USA
J Exp Med 200:581-6. 2004..Abrogation of amphiphysin IIm function results in C. pneumoniae-induced NO production and in the sterilization of the vacuole. The data suggest that C. pneumoniae retains amphiphysin IIm on the vacuole to survive within the macrophage...
- Chlamydophila pneumoniae and Mycoplasma pneumoniae in respiratory specimens of children with chronic lung diseasesN Teig
Children s Hospital of Ruhr University, St Josef Hospital, Bochum, Germany
Thorax 60:962-6. 2005Persistent infection with Mycoplasma pneumoniae and Chlamydophila pneumoniae has been implicated in the progression or induction of asthma and chronic obstructive pulmonary disease...
- Role of Chlamydia pneumoniae in atherosclerosisCaroline Watson
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
Clin Sci (Lond) 114:509-31. 2008..In the present review, we consider the experimental evidence that has accumulated over the last 20 years evaluating the role of C. pneumoniae in atherosclerosis and suggest areas for future research in this field...
- Acellular components of Chlamydia pneumoniae stimulate cytokine production in human blood mononuclear cellsM G Netea
Department of Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands
Eur J Immunol 30:541-9. 2000..In conclusion, acellular components of C. pneumoniae are a potent stimulus for cytokine production, and this mechanism may have an important role in the inflammatory aspects of atherogenesis...
- Deficiency of XIAP leads to sensitization for Chlamydophila pneumoniae pulmonary infection and dysregulation of innate immune response in miceHridayesh Prakash
Department of Molecular Biology, Max Planck Institute for Infection Biology, Chariteplatz 1, D 10117 Berlin, Germany
J Biol Chem 285:20291-302. 2010Obligate intracellular Chlamydophila pneumoniae induce apoptosis resistance in host cells to escape eradication by immune effector cells...
- Apolipoprotein E-deficient mice develop an anti-Chlamydophila pneumoniae T helper 2 response and resist vascular infectionDani Nazzal
Inserm Unité 858, Institute of Molecular Medicine of Rangueil, Institut Fédératif de Recherche F150, and University Paul Sabatier, Toulouse Cedex 4, France
J Infect Dis 202:782-90. 2010Hypercholesterolemia could inhibit the immune response against various pathogens. No information is available about its impact on the immune response toward Chlamydophila pneumoniae.
- Analysis of gene expression in penicillin G induced persistence of Chlamydia pneumoniaeM Di Pietro
Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy
J Biol Regul Homeost Agents 26:277-84. 2012..In conclusion, the Chlamydial expression pattern of hctA, hctB, and htrA genes may be helpful to identify target molecules to diagnose and treat Chlamydia-associated chronic diseases...
- Divergent modulation of Chlamydia pneumoniae infection cycle in human monocytic and endothelial cells by iron, tryptophan availability and interferon gammaRosa Bellmann-Weiler
Department of Internal Medicine I, Clinical Immunology and Infectious Diseases, Innsbruck, Austria
Immunobiology 215:842-8. 2010..pneumoniae biology in endothelial, but not monocytic cells. Our results contribute to a better understanding of C. pneumoniae infection and its role in chronic inflammatory diseases such as atherosclerosis...
- Stability of Chlamydophila pneumoniae in a harsh environment without a requirement for acanthamoebaeJunji Matsuo
Department of Medical Laboratory Sciences, Hokkaido University Graduate School of Health Sciences, Kita ku, Sapporo 060 0812, Hokkaido, Japan
Microbiol Immunol 54:63-73. 2010The effect of actual interactions between Chlamydophila pneumoniae and amoebae (Acanthamoeba) on the survival of C. pneumoniae was investigated. C. pneumoniae and amoebae were detected in 75 soil samples by IFU assay and PCR. Although C...
- The effect of Chlamydophila pneumoniae Major Outer Membrane Protein (MOMP) on macrophage and T cell-mediated immune responsesAlexandra Bermudez-Fajardo
University of Surrey, Faculty of Health and Medical Sciences, Guildford, UK
Immunobiology 216:152-63. 2011The Major Outer Membrane Protein (MOMP) belongs to the membrane complex of cysteine-rich proteins of Chlamydophila pneumoniae. Although MOMP can elicit strong immune responses it fails to confer long-term protection against infection in ..
- Chlamydophila pneumoniae (Chlamydia pneumoniae) accelerates the formation of complex atherosclerotic lesions in Apo E3-Leiden miceR Ezzahiri
Department of Surgery, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
Cardiovasc Res 56:269-76. 2002..To study the role of Chlamydophila pneumoniae (C...
- Interactions between flagellar and type III secretion proteins in Chlamydia pneumoniaeChris B Stone
M, G, DeGroote Institute for Infectious Disease Research, Faculty of Health Sciences and the Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
BMC Microbiol 10:18. 2010..Chlamydia pneumoniae is an obligate, intracellular pathogen whose genome contains at least three orthologs of flagellar proteins, namely FliI, FlhA and FliF, but the role of these proteins remains unknown...
- Detection of circulating Chlamydophila pneumoniae in patients with coronary artery disease and healthy control subjectsSarah Klizas West
Oregon Health and Science University, Portland, Oregon, USA
Clin Infect Dis 48:560-7. 2009There is a long history of research suggesting that Chlamydophila pneumoniae is associated with coronary artery disease (CAD). C...
- A randomized, controlled trial of doxycycline and rifampin for patients with Alzheimer's diseaseMark B Loeb
Department of Pathology and Molecular Medicine, Biostatistics Hamilton Regional Laboratory Medicine Program, Hamilton, Ontario, Canada
J Am Geriatr Soc 52:381-7. 2004..To assess whether doxycycline and rifampin have a therapeutic role in patients with Alzheimer's disease (AD)...
- The atherogenic effects of chlamydia are dependent on serum cholesterol and specific to Chlamydia pneumoniaeH Hu
Department of Medical Microbiology, Division of Stroke and Vascular Disease, St Boniface General Hospital Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3
J Clin Invest 103:747-53. 1999..pneumoniae atherogenesis and evaluating chlamydial intervention strategies for preventing the advancement of atherosclerotic lesions enhanced by C. pneumoniae infection...
- Prevalence of Chlamydia pneumoniae in acute respiratory tract infection and detection of anti-Chlamydia pneumoniae-specific IgE in Japanese children with reactive airway diseaseS Ikezawa
Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan
Kurume Med J 48:165-70. 2001..02748, to = 2.31891). In conclusion, C. pneumoniae seems to be an important respiratory tract pathogen among young Japanese children, and our results support the association of C. pneumoniae infection and reactive airway disease...
- Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6Nuria Rodriguez
Institut fur Medizinische Mikrobiologie, Immunology and Hygiene, Technische Universitat Munchen, Germany
J Leukoc Biol 88:579-87. 2010..the impact of DUSP1 on inflammatory and antimicrobial host responses to the intracellular pathogen Chlamydophila pneumoniae. Following nasal infection, DUSP1-deficient mice mounted an enhanced pulmonary cytokine (IL-1beta, IL-6) ..
- Emerging relations between infectious diseases and coronary artery disease and atherosclerosisI W Fong
Department of Medicine, St Michael s Hospital, Toronto, Ont
CMAJ 163:49-56. 2000..The results of large randomized clinical trials in progress will help establish causality and the benefits of antimicrobial therapy in CAD...
- Smoking, season, and detection of Chlamydia pneumoniae DNA in clinically stable COPD patientsMarek Smieja
Department of Pathology and Molecular Medicine, St Joseph s Healthcare and McMaster University, Hamilton ON Canada
BMC Infect Dis 2:12. 2002..The prevalence and role of Chlamydia pneumoniae in chronic obstructive pulmonary disease (COPD) remain unclear, and molecular methods of detection may help clarify this relationship...
- Circulating Chlamydia pneumoniae DNA as a predictor of coronary artery diseaseY K Wong
Molecular Microbiology Department, Southampton University Medical School, and Southampton General Hospital, United Kingdom
J Am Coll Cardiol 34:1435-9. 1999..To determine whether current vascular Chlamydia pneumoniae (CPn) infection as diagnosed by circulating CPn DNA is more common in subjects with coronary artery disease (CAD)...
- Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomasAndres J M Ferreri
Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
J Natl Cancer Inst 96:586-94. 2004..Hence, we assessed whether Chlamydiae infection is associated with the development of ocular adnexal lymphomas...
- Chlamydophila pneumoniae, Mycoplasma pneumoniae infections, and asthma controlKrzysztof Specjalski
Department of Allergology, Medical University of Gdansk, Poland
Allergy Asthma Proc 32:9-17. 2011..The aim of this study was to evaluate the impact of Chlamydophila pneumoniae and Mycoplasma pneumoniae infections on the control and severity of asthma...
- Genome sequence of the cat pathogen, Chlamydophila felisYoshinao Azuma
Department of Microbiology, Yamaguchi University School of Medicine, Ube, Yamaguchi 755 8505, Japan
DNA Res 13:15-23. 2006..The genomic DNA sequence of C. felis provides information for comprehension of diseases and elucidation of the chlamydial evolution...
- Lack of association between chronic Chlamydophila pneumoniae infection and lung cancer among nonsmoking Chinese women in SingaporeWoon Puay Koh
Int J Cancer 114:502-4. 2005
- Seroprevalence of Chlamydophila pneumoniae in ischaemic heart diseaseRosa Monno
Department of Internal Medicine and Public Health, University of Bari, Italy
New Microbiol 33:381-5. 2010We investigated the presence of Chlamydophila pneumoniae antibodies in 125 patients with cardiovascular disease and in 128 controls. C. pneumoniae antibodies were measured by microimmunofluorescence assay...
- Toll-like receptors 2 and 4 do not contribute to clearance of Chlamydophila pneumoniae in mice, but are necessary for the release of monokinesMarkus Mueller
Biochemical Pharmacology, University of Konstanz, Konstanz 78457, Germany
Immunobiology 209:599-608. 2004Activation of immune cells by Chlamydophila pneumoniae in vitro has been shown to be toll-like receptor (TLR2)-dependent, but TLR4 is also involved to a minor extent. To investigate the role of TLR2 and TLR4 in vivo, a murine model of C...
- Chlamydophila pneumoniae infection and COPD: more evidence for lack of evidence?Georgios S Papaetis
3rd Department of Medicine, University of Athens Medical School, Sotiria General Hospital, Athens, Greece
Eur J Intern Med 20:579-85. 2009b>Chlamydophila pneumoniae has been recognized as a common cause of respiratory tract infections affecting all age groups. The organism has been implicated as an infectious trigger for acute exacerbations of COPD...
- Induction of iNOS by Chlamydophila pneumoniae requires MyD88-dependent activation of JNKNuria Rodriguez
Institut fur Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universitat Munchen, Munchen, Germany
J Leukoc Biol 84:1585-93. 2008..NO plays an important role in host defense against intracellular bacteria including Chlamydophila pneumoniae as a result of its microbicidal activity. In MyD88-deficient mice, which succumb to C...
- Host molecular defense mechanisms against Chlamydophila pneumoniae and genetic studies of immune-response-related genes in asthmaMayumi Tamari
Laboratory for Respiratory Diseases, Center for Genomic Medicine, The Institute of Physical and Chemical Research RIKEN, Yokohama, Kanagawa, Japan
Recent Pat Inflamm Allergy Drug Discov 3:17-25. 2009b>Chlamydophila pneumoniae is an intracellular pathogen and a major cause of pneumonia that can cause chronic, persistent, and often asymptomatic, infections in target cells such as monocytes, macrophages, endothelial cells, fibroblasts, ..
- Molecular biology of infectious agents in chronic arthritisHerve C Gerard
Department of Immunology and Microbiology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
Rheum Dis Clin North Am 35:1-19. 2009....
- Simultaneous use of direct and indirect diagnostic techniques in atypical respiratory infections from Chlamydophila pneumoniae and Mycoplasma pneumoniaeS Pignanelli
DESOS Section of Microbiology, Policlinico S Orsola, University of Bologna, 40138, Bologna, Italy
J Clin Lab Anal 23:206-9. 2009..symptoms have been investigated using two real-time PCR methods: one assay for the single detection of Chlamydophila pneumoniae and Mycoplasma pneumoniae DNA and one commercially available real-time duplex PCR assay for the detection ..
- Evaluation of two real-time PCR chemistries for the detection of Chlamydophila pneumoniae in clinical specimensStephanie L Mitchell
Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA
Mol Cell Probes 23:309-11. 2009b>Chlamydophila pneumoniae is an atypical bacterial respiratory pathogen that is responsible for approximately 3-10% of community-acquired pneumonia cases...
- Erythema nodosum caused by ascariasis and Chlamydophila pneumoniae pulmonary infection--a case reportBeata Bergler-Czop
Department of Dermatology, Silesian Medical University in Katowice, Katowice, Poland
FEMS Immunol Med Microbiol 57:236-8. 2009..We present a case of erythema nodosum caused by Ascaris lumbricoides infection as well as by an early Chlamydophila pneumoniae infection, whose etiology has rarely been described in the literature...
- MyD88 is pivotal for the early inflammatory response and subsequent bacterial clearance and survival in a mouse model of Chlamydia pneumoniae pneumoniaYoshikazu Naiki
Division of Pediatrics Infectious Diseases and Immunology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90048, USA
J Biol Chem 280:29242-9. 2005..Thus, MyD88 is essential to recognize C. pneumoniae infection and initiate a prompt and effective immune host response against this organism leading to clearance of bacteria from infected lungs...
- Role of toll-like receptors in immune responses to chlamydial infectionsA G Joyee
Laboratory for Infection and Immunity, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3
Curr Pharm Des 14:593-600. 2008....
- Fate of Chlamydophila pneumoniae in human monocyte-derived dendritic cells: long lasting infectionUlrike Wittkop
Medizinische Hochschule Hannover, Department of Rheumatology, Carl Neuberg Strasse 1, Hannover 30625, Germany
Microb Pathog 40:101-9. 2006Earlier studies from this group demonstrated that Chlamydophila pneumoniae co-localized with dendritic cells (DC) in temporal artery biopsies from patients with giant cell arteritis (GCA). To investigate the interaction of DC with C...
- Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 releaseMihai G Netea
Department of Medicine, University Medical Center Nijmegen, The Netherlands
J Immunol 173:1477-82. 2004..Most interestingly, C. pneumoniae is also a potent inducer of IL-18 production through pathways independent of TLR2 and TLR4...
- Cutaneous vasculitis and reactive arthritis following respiratory infection due to Chlamydia pneumoniae: report of a caseA Cascina
Department of Haemathological, Pneumological and Cardiovascular Sciences and Respiratory Disease Clinic, University of Pavia, I R C C S Policlinico San Matteo, Pavia, Italy
Clin Exp Rheumatol 20:845-7. 2002..Therefore, since this infection is very common in our population, although often asymptomatic, should be systematically considered as a common causative agent of ReA and of vasculitis...
- Identification of Chlamydophila pneumoniae in an emerald tree boa, Corallus caninusElliott R Jacobson
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
J Vet Diagn Invest 16:153-4. 2004..Sequence analysis showed that the snake had been infected with Chlamydophila pneumoniae. These findings show that C...
- Infection of murine precision cut lung slices (PCLS) with respiratory syncytial virus (RSV) and chlamydophila pneumoniae using the Krumdieck techniqueM Ebsen
Department of Pathology, Ruhr University Bochum, Universitatsstr 150, 44801 Bochum, Germany
Pathol Res Pract 198:747-53. 2002..b>Chlamydophila pneumoniae (Cp) and respiratory syncytial virus (RSV) proved to be important causes of pneumonia, rhinitis and ..
- Chlamydia pneumoniae in elderly patients with stroke (C-PEPS): a case-control study on the seroprevalence of Chlamydia pneumoniae in elderly patients with acute cerebrovascular diseaseJoseph Ngeh
Department of Medicine for Elderly People, Whipps Cross University Hospital, London, UK
Cerebrovasc Dis 15:11-6. 2003..We investigated whether serological markers of C. pneumoniae infection were associated with acute stroke or transient ischaemic attack (TIA), exclusively in elderly patients...
- Detection of Chlamydophila pneumoniae in dendritic cells in atherosclerotic lesionsYuri V Bobryshev
Surgical Professional Unit, St Vincent s Hospital, University of New South Wales, Sydney, Australia
Atherosclerosis 173:185-95. 2004..The present work was undertaken to examine a possible association of DCs with Chlamydophila pneumoniae in human atherosclerotic plaques obtained by endarterectomy. C...
- Respiratory Panel Flow-Strip: a Point-of-Care Molecular Diagnostic TestCHRISTOPHER GERARD COONEY; Fiscal Year: 2012..parainfluenza virus 1/2/3/4, Haemophilus influenzae, Streptococcus pneumoniae, Mycoplasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophila, and Bordetella pertussis...
- Role of Innate Immune System in Pathogen Induced Chronic InflammationCaroline A Genco; Fiscal Year: 2013..The pathogenic bacteria Chlamydophila pneumoniae and Porphyromanas gingivalis induce a chronic inflammatory response, although how these pathogens induce ..
- Nanotechnology-Based Detection of Mycoplasma pneumoniaeDuncan C Krause; Fiscal Year: 2013..assess NA- SERS discriminatory ability in mixed infections with other bacterial pathogens including Chlamydophila pneumoniae;and (2) test by NA-SERS, true clinical throat swab samples previously established as positive or negative ..
- Inflammatory and Infectious Burden and Risk of StrokeMitchell Elkind; Fiscal Year: 2008..The cross-sectional associations between inflammatory and infectious markers and quantitative MRI abnormalities will also be assessed. ..
- Inflammation and Infection as Risk Factors in StrokeMitchell Elkind; Fiscal Year: 2006..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
- Levels of Inflammatory Markers in Treatment of StrokeMitchell Elkind; Fiscal Year: 2008..abstract_text> ..
- PATHOGENESIS OF CHLAMYDIAL OCULAR INFECTIONSDeborah Dean; Fiscal Year: 2004..A greater understanding of the pathogenesis of trachoma will aid in developing public health interventions and a vaccine that can be implemented in trachoma endemic areas throughout the world. ..
- Role of Chlamydia Pneumoniae in AtherosclerosisCho Chou Kuo; Fiscal Year: 2007..pneumoniae infection and reduction of atherosclerosis and coronary heart disease. ..
- Pathogenesis of Persistent Chlamydial STDsDeborah Dean; Fiscal Year: 2007..1 Description, ..
- C. trachomatis genomics, strain typing, and evolutionDeborah Dean; Fiscal Year: 2008..unreadable] [unreadable]..
- CHLAMYDIA PNEUMONIAE--A PATHOGEN IN ALZHEIMERS DISEASEAlan Hudson; Fiscal Year: 2002..Such new information may well provide important new insights for development of novel therapeutic modalities to prevent or ameliorate late-onset AD. ..
- Reiter's syndrome mechanism of chlamydial pathogenesisAlan Hudson; Fiscal Year: 2008....
- Environmental Toxicants in Fetal Basis of Adult-onset StrokeVICTORIA HERRERA; Fiscal Year: 2007..Currently, environmental subtoxicant-induced fetal programming is not factored in as confounder in genetic studies of susceptibility to complex multifactorial diseases. ..
- Diesel Exhaust and Atherosclerotic Plaque StabilityMichael Rosenfeld; Fiscal Year: 2007....
- Glutathione, macrophages and unstable atherosclerosisMichael Rosenfeld; Fiscal Year: 2007..abstract_text> ..
- 2007 Atherosclerosis Gordon Research ConferenceMichael Rosenfeld; Fiscal Year: 2007..The [unreadable] conference will provide a comprehensive overview of current research on [unreadable] atherosclerosis with a focus on the latest and most exciting developments in the field. [unreadable] [unreadable] [unreadable]..
- Prenatal Malnutrition and the Aging BrainVICTORIA HERRERA; Fiscal Year: 2006..abstract_text> ..
- A randomized trial of influenza vaccination of Hutterite childrenMark Loeb; Fiscal Year: 2006..We believe that the trial we propose will lead to important data that can inform policy on influenza immunization strategy. [unreadable] [unreadable] [unreadable]..
- Cytotoxic T Cell Responses to Virus InfectionJ Whitton; Fiscal Year: 2008..T cells proliferate in response to antigen contact only in lymphoid tissues, or do they also divide when they encounter antigen elsewhere? Can we increase the number of memory cells, thus enhancing protective immunity? ..
- EVOLUTION OF IMMUNE RECOGNITION AND EVASIONAustin L Hughes; Fiscal Year: 2010..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
- Chaperone Mining of the Chlamydia Type Three Secretion SystemELLENA MARIE PETERSON; Fiscal Year: 2010..Having an understanding of the critical elements of the Chlamydia TTS system should lead to the development of strategies to subvert the TTS system with the ultimate goal of attenuating or preventing infections with this pathogen. ..
- Pilot Trial of Metformin in Amnestic MCIJose A Luchsinger; Fiscal Year: 2010....
- HDL Dysfunction and Vascular InflammationKirkwood A Pritchard; Fiscal Year: 2010..Through these studies, new treatment modalities may be realized for preventing vascular dysfunction in a variety of diseases characterized by increases in oxidative stress and inflammation. ..
- HYPERTENSION / ATHEROSCLEROSIS PARADIGMSVICTORIA HERRERA; Fiscal Year: 2002..This research proposal will provide key information on mechanisms that underlie the acceleration of atherosclerosis by hypertension which will identify new strategies for intervention. ..
- C. Pneumoniae and atherosclerotic plaque destabilizationMichael E Rosenfeld; Fiscal Year: 2010..4. To determine whether exposure of young versus old mice to air pollution increases the susceptibility of the mice to C. pneumoniae infection and accelerates the development and progression of atherosclerosis. ..
- Maternal Obesity, Fetal Genomics, and Atherosclerotic Metabolic RiskDavid Siscovick; Fiscal Year: 2009..The long-term goals of the proposed study are to identify potential mechanistic targets for interventions to prevent the consequences of MO on the intra-uterine environment and adult AMR. ..
- Innate Immunity and exacerbations of COPDSanjay Sethi; Fiscal Year: 2009..The overall goal of this research is to identify specific aspects of the innate defense of the lung that determine the frequency of exacerbations in COPD that will serve as potential therapeutic targets to reduce exacerbations. ..
- PATHOGENIC MECHANISMS IN UTIWalter Stamm; Fiscal Year: 2007..Face Page .................................................................................................. 1 B. Description, ..
- Gene Expression in Acute and Chronic Neurologic DiseaseDonald Gilden; Fiscal Year: 2008..This concerted effort is focused on prospective studies to delineate the cause, pathogenesis and eventual prevention of viral and demyelinating diseases of the human nervous system. ..
- HIV-Related Proteinuria and Endothelial DysfunctionSamir Gupta; Fiscal Year: 2007..Dub6) in the fields of HIV metabolic and renal complications, renal vascular and glomerular pathology, and clinical trials design and implementation. ..
- Inflammation Genomics and AtherosclerosisDavid Siscovick; Fiscal Year: 2006..abstract_text> ..
- MACROPHAGE ACTIVATION AND LIPOPROTEIN METABOLISMMaria Lopes Virella; Fiscal Year: 2001..Our overall objective is to provide insight into the mechanisms by which anti-LDL antibodies and macrophage activation may contribute to the development(acceleration of the arteriosclerotic process. ..
- Chlamydia trachomatis, Genital Flora, & STD PathogenesisGerald Byrne; Fiscal Year: 2004..This hypothesis will be tested by determining the effects of indole-producing normal flora on chlamydial genital tract disease in a well-characterized murine model. ..
- Functional Senescence of Innate Immunity and PneumoniaKevin High; Fiscal Year: 2003..These data are essential to design meaningful studies using the case-control method, the most effective means of studying the link between immune senescence and infection risk. ..
- Androgens and subclinical atherosclerosis in young womenDavid Siscovick; Fiscal Year: 2003..In short, the proposed study addresses a potentially important and relatively unexplored area of investigation related to women's cardiovascular health. ..
- HAEMOPHILUS ANTIGEN REGULATION OF INFLAMMATION IN COPDSanjay Sethi; Fiscal Year: 2003..Identification of the integral bacterial and host components that contribute to immune-mediated inflammation in COPD will ultimately lead to novel therapeutic strategies to alter disease progression and improve outcome in COPD. ..
- AZITHROMYCIN AND CORONARY ARTERY DISEASEJ Grayston; Fiscal Year: 2003..The results of this study will provide important information on the potential role of antibiotic therapy for the secondary prevention of complication of coronary artery disease. ..
- ANALYSIS OF ASSOCIATION BETWEEN C. PNEUMONIAE AND MSSubramaniam Sriram; Fiscal Year: 2002..Also, the presence of an immune response to C. pneumoniae that is contained within the CNS compartment will constitute strong circumstantial evidence of microbial infection. ..
- DIETARY FATTY CONTROL OF INFLAMMATIONKevin High; Fiscal Year: 2002..Health relateness: Answering these fundamental questions will shed critical light on the feasibility of utilizing dietary fatty acids to regulate AA metabolism and related clinical disorders. ..
- ENHANCEMENT OF DNA VACCINE IMMUNOGENICITYJ Whitton; Fiscal Year: 2002..The knowledge from aims 1-3 will be drawn together to optimize induction of antibodies, CD4+ T cells, and CD8+ T cells each of which probably will have unique requirements for optimal responses. ..
- TRANSGENIC RAT MODELS OF ALZHEIMER'S DISEASEVICTORIA HERRERA; Fiscal Year: 2002..abstract_text> ..
- HOMOCYSTEINE, INFLAMMATION, AND ATHEROGENESISMichael Rosenfeld; Fiscal Year: 2001..Under Aim 2, the investigator will determine the mechanism by which HC and lipid accumulation alter glutathione and NADH/NADPH metabolism, thereby activating macrophages in vitro. ..
- Vascular factors, amyloid beta, and Alzheimer's diseaseJose Luchsinger; Fiscal Year: 2004..abstract_text> ..
- Gene Duplication and Genome EvolutionAustin Hughes; Fiscal Year: 2004..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
- Population-based Surveillance for Zoonotic Influenza AGregory Gray; Fiscal Year: 2005..We are particularly well suited to conduct this work as we have extensive experience conducting both epidemiological and laboratory-based studies of respiratory pathogens. ..
- Novel oral therapeutics for multiple sclerosisSubramaniam Sriram; Fiscal Year: 2006....
- Brucella, Aging and Role of IL-17 in Host DefenseKevin High; Fiscal Year: 2005..The data generated in this proposal will form the foundation of future R01 proposals aimed at enhancing immunity vs. intracellular pathogens in our aging population. ..
- Polyunsaturated fats & risk of primary cardiac arrestDavid Siscovick; Fiscal Year: 2005..The proposed research provides a unique opportunity to examine more fully the role of dietary intake of n-3 PUFAs, particularly ALA, in efforts to reduce PCA, a major component of coronary heart disease mortality in the community. ..
- Human Metapneumovirus in High Risk PopulationsGregory Gray; Fiscal Year: 2005..These data will facilitate the development of more comprehensive epidemiological studies, and guide future intervention studies in reducing HMPV morbidity. ..
- CD8+T cell responses to Chlamydia pneumoniaeBenjamin Wizel; Fiscal Year: 2006..pneumoniae and will suggest methods of immunological intervention in infections caused by C. pneumoniae and other chlamydial pathogens. ..
- ANGIOTENSIN II AND REGULATION OF MCP-1 GENE EXPRESSIONChangyi Chen; Fiscal Year: 2002....
- Molecular Surgeon Symposium on Vascular Injury, RepairChangyi Chen; Fiscal Year: 2005..A pre-approved letter for acceptance of submission of this application from NIH/NHLBI is included. ..
- Obesity, Inflammation and Response to Therapy in AsthmaEVERETT RAND SUTHERLAND; Fiscal Year: 2010..End of Abstract) ..
- Molecular Surgeon Symposium on Genetics and Genomics of Pancreatic CancerChangyi Chen; Fiscal Year: 2008..Furthermore, invited speakers are encouraged to submit manuscripts related to their presentations to "World Journal of Surgery" for consideration of publications. [unreadable] [unreadable] [unreadable]..
- Effects of HIV Protease Inhibitors of Endothelial BarrieChangyi Chen; Fiscal Year: 2005..Our findings may also suggest new therapeutic strategies, which may eventually prove effective for the prevention and treatment of these complications. ..
- Hsp90 Mediates eNOS and Vascular FunctionKirkwood Pritchard; Fiscal Year: 2005..Findings from these studies will probably be relevant to and provide new understanding of mechanisms mediating vascular disease related to atherogenesis, hypertension and diabetes ..
- Tissue engineering of small diameter vascular graftChangyi Chen; Fiscal Year: 2006..Success of this proposal will directly indicate the clinical applications of tissue engineered small diameter vascular grafts. ..
- Effects of HAART drugs on endothelial dysfunction of pu*Changyi Chen; Fiscal Year: 2009..abstract_text> ..
- Risk of Blood Borne Transmission of CJDShimian Zou; Fiscal Year: 2008..Publishanddisseminateresultsof thestudy. ..
- HIV PROTEASE INHIBITORS EFFECT--NENDOTHELIAL DYSFUNCTIONChangyi Chen; Fiscal Year: 2004..Together, the integrated basic science, non-human primate and human investigations offer a multi disciplinary approach to the understanding and prevention of protease inhibitor-associated vascular complications. ..
- Native LDL, Cholesterol and Impaired VasodilationKirkwood Pritchard; Fiscal Year: 2006..Investigations in to how 4F protects vascular function will provide new understanding of the mechanisms by which LDL impairs vasodilation and HDL protects vascular function. ..
- HIV/SIV ENVELOPE GLYCOPROTEIN EFFECTS ON ENDOTHELIAChangyi Chen; Fiscal Year: 2002....