chlamydia trachomatis

Summary

Summary: Type species of CHLAMYDIA causing a variety of ocular and urogenital diseases.

Top Publications

  1. pmc Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development
    Cherilyn A Elwell
    Department of Medicine, University of California, San Francisco, California, United States of America
    PLoS Pathog 7:e1002198. 2011
  2. pmc Interplay of recombination and selection in the genomes of Chlamydia trachomatis
    Sandeep J Joseph
    Department of Medicine, Division of Infectious, Diseases Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Biol Direct 6:28. 2011
  3. pmc Deep sequencing-based discovery of the Chlamydia trachomatis transcriptome
    Marco Albrecht
    University of Wurzburg, Biocentre, Department of Microbiology, Am Hubland, D 97074 Wurzburg, Germany
    Nucleic Acids Res 38:868-77. 2010
  4. pmc A new metabolic cell-wall labelling method reveals peptidoglycan in Chlamydia trachomatis
    G W Liechti
    1 Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814 4799, USA 2
    Nature 506:507-10. 2014
  5. pmc Transmission of Chlamydia trachomatis through sexual partnerships: a comparison between three individual-based models and empirical data
    Christian L Althaus
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    J R Soc Interface 9:136-46. 2012
  6. pmc Genome sequencing of recent clinical Chlamydia trachomatis strains identifies loci associated with tissue tropism and regions of apparent recombination
    Brendan M Jeffrey
    Department of Biomedical Sciences, Oregon State University, Corvallis, Oregon 97331 4804, USA
    Infect Immun 78:2544-53. 2010
  7. ncbi Sexual behaviour in Britain: reported sexually transmitted infections and prevalent genital Chlamydia trachomatis infection
    K A Fenton
    Centre for Infectious Disease Epidemiology, Department of Primary Care, Royal Free and University College London Medical School, London, UK
    Lancet 358:1851-4. 2001
  8. doi Transmission dynamics of Chlamydia trachomatis affect the impact of screening programmes
    Christian L Althaus
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Epidemics 2:123-31. 2010
  9. doi Typing Chlamydia trachomatis: from egg yolk to nanotechnology
    Lisbeth Nørum Pedersen
    Department of Clinical Microbiology, Aarhus University Hospital, Skejby, Denmark
    FEMS Immunol Med Microbiol 55:120-30. 2009
  10. pmc Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors
    G Zhong
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    J Exp Med 193:935-42. 2001

Detail Information

Publications360 found, 100 shown here

  1. pmc Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development
    Cherilyn A Elwell
    Department of Medicine, University of California, San Francisco, California, United States of America
    PLoS Pathog 7:e1002198. 2011
    The strain designated Chlamydia trachomatis serovar that was used for experiments in this paper is Chlamydia muridarum, a species closely related to C. trachomatis (and formerly termed the Mouse Pneumonitis strain of C. trachomatis...
  2. pmc Interplay of recombination and selection in the genomes of Chlamydia trachomatis
    Sandeep J Joseph
    Department of Medicine, Division of Infectious, Diseases Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Biol Direct 6:28. 2011
    b>Chlamydia trachomatis is an obligate intracellular bacterial parasite, which causes several severe and debilitating diseases in humans. This study uses comparative genomic analyses of 12 complete published C...
  3. pmc Deep sequencing-based discovery of the Chlamydia trachomatis transcriptome
    Marco Albrecht
    University of Wurzburg, Biocentre, Department of Microbiology, Am Hubland, D 97074 Wurzburg, Germany
    Nucleic Acids Res 38:868-77. 2010
    b>Chlamydia trachomatis is an obligate intracellular pathogenic bacterium that has been refractory to genetic manipulations...
  4. pmc A new metabolic cell-wall labelling method reveals peptidoglycan in Chlamydia trachomatis
    G W Liechti
    1 Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814 4799, USA 2
    Nature 506:507-10. 2014
    ..Replicating Chlamydia trachomatis were labelled with these probes throughout their biphasic developmental life cycle, and the results of ..
  5. pmc Transmission of Chlamydia trachomatis through sexual partnerships: a comparison between three individual-based models and empirical data
    Christian L Althaus
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    J R Soc Interface 9:136-46. 2012
    b>Chlamydia trachomatis is the most common bacterial sexually transmitted infection (STI) in many developed countries. The highest prevalence rates are found among young adults who have frequent partner change rates...
  6. pmc Genome sequencing of recent clinical Chlamydia trachomatis strains identifies loci associated with tissue tropism and regions of apparent recombination
    Brendan M Jeffrey
    Department of Biomedical Sciences, Oregon State University, Corvallis, Oregon 97331 4804, USA
    Infect Immun 78:2544-53. 2010
    The human pathogen Chlamydia trachomatis exists as multiple serovariants that have distinct organotropisms for different tissue sites...
  7. ncbi Sexual behaviour in Britain: reported sexually transmitted infections and prevalent genital Chlamydia trachomatis infection
    K A Fenton
    Centre for Infectious Disease Epidemiology, Department of Primary Care, Royal Free and University College London Medical School, London, UK
    Lancet 358:1851-4. 2001
    ..Natsal 2000) in Britain, we estimated the frequency of self-reported STIs, and the prevalence of urinary Chlamydia trachomatis infection...
  8. doi Transmission dynamics of Chlamydia trachomatis affect the impact of screening programmes
    Christian L Althaus
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Epidemics 2:123-31. 2010
    To assess the impact of screening programmes in reducing the prevalence of Chlamydia trachomatis, mathematical and computational models are used as a guideline for decision support...
  9. doi Typing Chlamydia trachomatis: from egg yolk to nanotechnology
    Lisbeth Nørum Pedersen
    Department of Clinical Microbiology, Aarhus University Hospital, Skejby, Denmark
    FEMS Immunol Med Microbiol 55:120-30. 2009
    A historical review is provided of the various methods used for half a century to differentiate and type Chlamydia trachomatis strains. Typing of C...
  10. pmc Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors
    G Zhong
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    J Exp Med 193:935-42. 2001
    ..Thus, CPAF represents a unique secreted protein produced by an obligate intracellular bacterial pathogen to interfere with effective host adaptive immunity...
  11. pmc Localization of Chlamydia trachomatis hypothetical protein CT311 in host cell cytoplasm
    Lei Lei
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Microb Pathog 51:101-9. 2011
    ..hypothetical protein CT311 was detected both inside and outside of the chlamydial inclusions in Chlamydia trachomatis-infected cells...
  12. pmc Chlamydia trachomatis persistence in vitro: an overview
    Priscilla B Wyrick
    Department of Microbiology, J H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Infect Dis 201:S88-95. 2010
    ....
  13. pmc Chlamydial persistence: beyond the biphasic paradigm
    Richard J Hogan
    Infectious Diseases Program and Cooperative Research Centre for Diagnostics, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Infect Immun 72:1843-55. 2004
  14. pmc Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing
    Simon R Harris
    Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nat Genet 44:413-9, S1. 2012
    b>Chlamydia trachomatis is responsible for both trachoma and sexually transmitted infections, causing substantial morbidity and economic cost globally. Despite this, our knowledge of its population and evolutionary genetics is limited...
  15. doi Risk of sequelae after Chlamydia trachomatis genital infection in women
    Catherine L Haggerty
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Infect Dis 201:S134-55. 2010
    b>Chlamydia trachomatis infection, the most common reportable disease in the United States, can lead to pelvic inflammatory disease (PID), infertility, ectopic pregnancy, and chronic pelvic pain. Although C...
  16. pmc Pathogenesis of genital tract disease due to Chlamydia trachomatis
    Toni Darville
    Departments of Pediatrics and Immunology, University of Pittsburgh Medical Cente, USA
    J Infect Dis 201:S114-25. 2010
    ....
  17. pmc Cytoplasmic lipid droplets are translocated into the lumen of the Chlamydia trachomatis parasitophorous vacuole
    Jordan L Cocchiaro
    Center for Microbial Pathogenesis, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 105:9379-84. 2008
    ..of host-derived lipids is essential for the pathogenesis of the obligate intracellular bacteria Chlamydia trachomatis. Current models of chlamydial lipid acquisition center on the fusion of Golgi-derived exocytic vesicles ..
  18. pmc STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection
    Jeffrey R Barker
    Department of Molecular Genetics and Microbiology, Center for Microbial Pathogenesis, Duke University, Durham, North Carolina, USA
    MBio 4:e00018-13. 2013
    ..The membrane-bound obligate intracellular bacterium Chlamydia trachomatis induces a STING-dependent type I IFN response in infected cells, yet the IFN-inducing ligand remains ..
  19. ncbi Chlamydia trachomatis enters a viable but non-cultivable (persistent) state within herpes simplex virus type 2 (HSV-2) co-infected host cells
    Srilekha Deka
    Department of Microbiology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    Cell Microbiol 8:149-62. 2006
    ..and clinical studies have shown that double infection with herpes simplex virus type 2 (HSV-2) and Chlamydia trachomatis occurs in vivo. We hypothesized that co-infection would alter replication of these agents...
  20. pmc Population genomics of Chlamydia trachomatis: insights on drift, selection, recombination, and population structure
    Sandeep J Joseph
    Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, USA
    Mol Biol Evol 29:3933-46. 2012
    ..number of sexually transmitted diseases and ocular trachoma cases that are caused globally each year by Chlamydia trachomatis has made this organism a World Health Organization priority for vaccine development...
  21. pmc Chlamydia trachomatis infection among 15- to 35-year-olds in Baltimore, MD
    Elizabeth Eggleston
    Statistics and Epidemiology Division, Research Triangle Institute, Washington, DC 20015, USA
    Sex Transm Dis 38:743-9. 2011
    b>Chlamydia trachomatis (Ct) is the most frequently reported infectious disease in the United States...
  22. pmc Effectiveness of yearly, register based screening for chlamydia in the Netherlands: controlled trial with randomised stepped wedge implementation
    Ingrid V F van den Broek
    Unit of Epidemiology and Surveillance, RIVM Centre for Infectious Disease Control Netherlands, PO Box 1, 3720 BA Bilthoven, Netherlands
    BMJ 345:e4316. 2012
    ..To evaluate the effectiveness of register based, yearly chlamydia screening...
  23. pmc Evaluation of high-resolution typing methods for Chlamydia trachomatis in samples from heterosexual couples
    Reinier J M Bom
    Public Health Laboratory, Public Health Service of Amsterdam, Nieuwe Achtergracht 100, 1018 WT Amsterdam, The Netherlands
    J Clin Microbiol 49:2844-53. 2011
    We aimed to compare conventional ompA typing of Chlamydia trachomatis with multilocus sequence typing (MLST) and multilocus variable-number tandem-repeat (VNTR) analysis (MLVA)...
  24. pmc Diagnostic accuracy of a prototype point-of-care test for ocular Chlamydia trachomatis under field conditions in The Gambia and Senegal
    Emma M Harding-Esch
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 5:e1234. 2011
    The clinical signs of active trachoma are often present in the absence of ocular Chlamydia trachomatis infection in low prevalence and mass treated settings...
  25. pmc Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis
    Ali A Abdul-Sater
    Health Sciences Research Institute and School of Natural Sciences, University of California, Merced, California 95343, USA
    J Biol Chem 284:26789-96. 2009
    ..Here we show that cervical epithelial cells express a functional inflammasome. Infection of the cells by Chlamydia trachomatis leads to activation of caspase-1, through a process requiring the NOD-like receptor family member NLRP3 ..
  26. pmc Chlamydia trachomatis secretion of an immunodominant hypothetical protein (CT795) into host cell cytoplasm
    Manli Qi
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Bacteriol 193:2498-509. 2011
    ..The above characterizations of CT795 have provided important information for further understanding the potential roles of CT795 in C. trachomatis pathogenesis...
  27. pmc Penicillin induced persistence in Chlamydia trachomatis: high quality time lapse video analysis of the developmental cycle
    Rachel J Skilton
    Molecular Microbiology Group, University of Southampton Medical School, Southampton General Hospital, Southampton, UK
    PLoS ONE 4:e7723. 2009
    b>Chlamydia trachomatis is a major human pathogen with a unique obligate intracellular developmental cycle that takes place inside a modified cytoplasmic structure known as an inclusion...
  28. pmc Chlamydia trachomatis plasmid-encoded Pgp4 is a transcriptional regulator of virulence-associated genes
    Lihua Song
    Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    Infect Immun 81:636-44. 2013
    b>Chlamydia trachomatis causes chronic inflammatory diseases of the eye and genital tract and has global medical importance...
  29. pmc Specific chlamydial inclusion membrane proteins associate with active Src family kinases in microdomains that interact with the host microtubule network
    Jeffrey Mital
    Host Parasite Interactions Section, Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA
    Cell Microbiol 12:1235-49. 2010
    ..b>Chlamydia trachomatis replicates within a vacuole termed an inclusion, which is extensively modified by the insertion of a ..
  30. pmc Development of a transformation system for Chlamydia trachomatis: restoration of glycogen biosynthesis by acquisition of a plasmid shuttle vector
    Yibing Wang
    Molecular Microbiology Group, University of Southampton Medical School, Southampton General Hospital, Southampton, United Kingdom
    PLoS Pathog 7:e1002258. 2011
    b>Chlamydia trachomatis remains one of the few major human pathogens for which there is no transformation system. C. trachomatis has a unique obligate intracellular developmental cycle...
  31. pmc RNA interference screen identifies Abl kinase and PDGFR signaling in Chlamydia trachomatis entry
    Cherilyn A Elwell
    Department of Medicine, University of California San Francisco, California, USA
    PLoS Pathog 4:e1000021. 2008
    The strain designated Chlamydia trachomatis serovar L2 that was used for experiments in this paper is Chlamydia muridarum, a species closely related to C. trachomatis (and formerly termed the Mouse Pneumonitis strain of C. trachomatis)...
  32. pmc Biological characterization of Chlamydia trachomatis plasticity zone MACPF domain family protein CT153
    Lacey D Taylor
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 78:2691-9. 2010
    b>Chlamydia trachomatis strains are obligate intracellular human pathogens that share near genomic synteny but have distinct infection and disease organotropisms...
  33. ncbi The natural course of Chlamydia trachomatis infection in asymptomatic Colombian women: a 5-year follow-up study
    Monica Molano
    Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Infect Dis 191:907-16. 2005
    The natural course of Chlamydia trachomatis infection and its risk factors were studied in Colombian women with normal cytological results, during a 5-year period. Eighty-two women who were found to be positive for C...
  34. doi Herpes simplex virus co-infection-induced Chlamydia trachomatis persistence is not mediated by any known persistence inducer or anti-chlamydial pathway
    Jennifer Vanover
    Department of Microbiology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 0579, USA
    Microbiology 154:971-8. 2008
    ..A tissue-culture model of Chlamydia trachomatis/herpes simplex virus type-2 (HSV-2) co-infection indicates that viral co-infection stimulates the ..
  35. pmc Trachoma prevalence and associated risk factors in the gambia and Tanzania: baseline results of a cluster randomised controlled trial
    Emma M Harding-Esch
    Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 4:e861. 2010
    Blinding trachoma, caused by ocular infection with Chlamydia trachomatis, is targeted for global elimination by 2020. Knowledge of risk factors can help target control interventions.
  36. doi Genomic features beyond Chlamydia trachomatis phenotypes: what do we think we know?
    Alexandra Nunes
    Department of Infectious Diseases, National Institute of Health, Av Padre Cruz, 1649 016 Lisbon, Portugal
    Infect Genet Evol 16:392-400. 2013
    The obligate intracellular pathogen Chlamydia trachomatis is the causative agent of the blinding trachoma and the world's leading cause of bacterial sexually transmitted infections. Despite aggressive antibacterial control measures, C...
  37. pmc Directional evolution of Chlamydia trachomatis towards niche-specific adaptation
    Vítor Borges
    Department of Infectious Diseases, National Institute of Health, Lisbon, Portugal
    J Bacteriol 194:6143-53. 2012
    ..We studied the obligate intracellular bacterium Chlamydia trachomatis, for which same-species strains display a nearly identical core and pan genome, while presenting a wide ..
  38. ncbi Pre-exposure of infected human endometrial epithelial cells to penicillin in vitro renders Chlamydia trachomatis refractory to azithromycin
    Priscilla B Wyrick
    Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    J Antimicrob Chemother 54:79-85. 2004
    ..epithelial cells (HEC-1B) provided the opportunity to establish a model system to determine if a persistent form of Chlamydia trachomatis had the same susceptibility as the actively growing form to a cidal concentration of azithromycin.
  39. doi Comparison of an in-house PCR assay, direct fluorescence assay and the Roche AMPLICOR Chlamydia trachomatis kit for detection of C. trachomatis
    Poonam Sachdeva
    Dr B R Ambedkar Center for Biomedical Research, University of Delhi, Delhi, India
    J Med Microbiol 58:867-73. 2009
    To improve the control of Chlamydia trachomatis infection in India, a rapid, specific and cost-effective method is much needed. We developed an in-house PCR assay by targeting a unique genomic sequence encoding a protein from the C...
  40. doi Who participates in the Dutch Chlamydia screening? A study on demographic and behavioral correlates of participation and positivity
    Eline L M Op de Coul
    Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Sex Transm Dis 39:97-103. 2012
    ..We studied who was reached in the first screening round by relating participation and chlamydia positivity to sociodemographic and sexual risk factors...
  41. pmc The chlamydial periplasmic stress response serine protease cHtrA is secreted into host cell cytosol
    Xiang Wu
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    BMC Microbiol 11:87. 2011
    ..The periplasmic High Temperature Requirement protein A (HtrA) plays important roles in bacterial protein folding and stress responses. However, the role of chlamydial HtrA (cHtrA) in chlamydial pathogenesis is not clear...
  42. pmc Internet-based screening for sexually transmitted infections to reach nonclinic populations in the community: risk factors for infection in men
    Shua J Chai
    Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD 21205, USA
    Sex Transm Dis 37:756-63. 2010
    ..No prior published data describe internet-based screening for Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis in men...
  43. ncbi Comparative model-based analysis of screening programs for Chlamydia trachomatis infections
    M Kretzschmar
    Department of Infectious Disease Epidemiology, National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Am J Epidemiol 153:90-101. 2001
    The design of a screening program for asymptomatic genital infections with Chlamydia trachomatis, requires decisions about which sex or age group should be targeted and whether partner referral should be included in the program...
  44. pmc Coverage and uptake of systematic postal screening for genital Chlamydia trachomatis and prevalence of infection in the United Kingdom general population: cross sectional study
    John Macleod
    Department of Primary Care and General Practice, University of Birmingham, Birmingham B15 2TT
    BMJ 330:940. 2005
    To measure the coverage and uptake of systematic postal screening for genital Chlamydia trachomatis and the prevalence of infection in the general population in the United Kingdom. To investigate factors associated with these measures.
  45. doi Genital Chlamydia trachomatis infections
    C Bebear
    Laboratoire de Bactériologie EA 3671, Infections Humaines à Mycoplasmes et Chlamydiae, CNR des Infections à Chlamydiae, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Clin Microbiol Infect 15:4-10. 2009
    b>Chlamydia trachomatis infections affect young, sexually active persons. Risk factors include multiple partners and failure to use condoms. The incidence of infection has increased in the past 10 years. Untreated C...
  46. ncbi Sperm DNA fragmentation in infertile men with genitourinary infection by Chlamydia trachomatis and Mycoplasma
    Guadalupe Gallegos
    Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Nuevo Leon, Mexico
    Fertil Steril 90:328-34. 2008
    ..the frequency of sperm cells with fragmented DNA in semen samples from men with genitourinary infection by Chlamydia trachomatis and Mycoplasma and the influence of antibiotic therapy, using the sperm chromatin dispersion test with the ..
  47. pmc Human conjunctival transcriptome analysis reveals the prominence of innate defense in Chlamydia trachomatis infection
    Angels Natividad
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, University of London, London, United Kingdom
    Infect Immun 78:4895-911. 2010
    ..Infection of the conjunctival epithelial cells by the causative bacterium, Chlamydia trachomatis, stimulates an acute host response...
  48. pmc Evaluation of a high resolution genotyping method for Chlamydia trachomatis using routine clinical samples
    Yibing Wang
    Molecular Microbiology and Infection, School of Medicine, University of Southampton, Southampton, United Kingdom
    PLoS ONE 6:e16971. 2011
    ....
  49. pmc Repeated Chlamydia trachomatis genital infections in adolescent women
    Byron E Batteiger
    Divisions of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana 46202 5112, USA
    J Infect Dis 201:42-51. 2010
    Repeated Chlamydia trachomatis infections are common among young sexually active women. The relative frequency of reinfection and antibiotic treatment failure is undefined.
  50. pmc Adult male circumcision does not reduce the risk of incident Neisseria gonorrhoeae, Chlamydia trachomatis, or Trichomonas vaginalis infection: results from a randomized, controlled trial in Kenya
    Supriya D Mehta
    Department of Epidemiology, University of Illinois at Chicago School of Public Health, Chicago, Illinois, USA
    J Infect Dis 200:370-8. 2009
    ..We examined the effect of male circumcision on the acquisition of 3 nonulcerative sexually transmitted infections (STIs)...
  51. pmc Maximising retention in a longitudinal study of genital Chlamydia trachomatis among young women in Australia
    Jennifer Walker
    Centre for Women s Health, Gender and Society, School of Population Health, University of Melbourne, Victoria 3010, Australia
    BMC Public Health 11:156. 2011
    ..The aims of this paper are to describe the methods used to recruit and retain young women in a longitudinal study and to explore factors associated with loss to follow up...
  52. pmc Performance of the Abbott RealTime CT/NG for detection of Chlamydia trachomatis and Neisseria gonorrhoeae
    C A Gaydos
    Johns Hopkins University, 855 North Wolfe St, 530 Rangos Building, Baltimore, MD 21205, USA
    J Clin Microbiol 48:3236-43. 2010
    ..of the Abbott RealTime CT/NG assay, a multiplex real-time PCR assay, for simultaneous detection of Chlamydia trachomatis and Neisseria gonorrhoeae...
  53. pmc Quantitative proteomics reveals metabolic and pathogenic properties of Chlamydia trachomatis developmental forms
    Hector A Saka
    Department of Molecular Genetics and Microbiology and Center for Microbial Pathogenesis, Duke University Medical Center, Durham, NC, USA
    Mol Microbiol 82:1185-203. 2011
    b>Chlamydia trachomatis is an obligate intracellular pathogen responsible for ocular and genital infections of significant public health importance. C...
  54. pmc Rationale, design, and results of the first screening round of a comprehensive, register-based, Chlamydia screening implementation programme in the Netherlands
    Jan E A M van Bergen
    STI AIDS Netherlands, Amsterdam, The Netherlands
    BMC Infect Dis 10:293. 2010
    Implementing Chlamydia trachomatis screening in the Netherlands has been a point of debate for several years...
  55. pmc Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy
    Julie L V Shaw
    Centre for Reproductive Biology, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Am J Pathol 178:253-60. 2011
    b>Chlamydia trachomatis and smoking are major risk factors for tubal ectopic pregnancy (EP), but the underlying mechanisms of these associations are not completely understood...
  56. ncbi Women find it easy and prefer to collect their own vaginal swabs to diagnose Chlamydia trachomatis or Neisseria gonorrhoeae infections
    Max A Chernesky
    St Joseph s Healthcare, Hamilton, Ontario, Canada
    Sex Transm Dis 32:729-33. 2005
    Self-collected specimens can be used to screen asymptomatic women for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC)...
  57. ncbi Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis
    R S Stephens
    Program in Infectious Diseases, University of California, Berkeley, CA 94720, USA
    Science 282:754-9. 1998
    Analysis of the 1,042,519-base pair Chlamydia trachomatis genome revealed unexpected features related to the complex biology of chlamydiae...
  58. pmc Co-evolution of genomes and plasmids within Chlamydia trachomatis and the emergence in Sweden of a new variant strain
    Helena M B Seth-Smith
    Molecular Microbiology Group, University Medical School, Southampton General Hospital, Southampton, SO16 6YD, UK
    BMC Genomics 10:239. 2009
    b>Chlamydia trachomatis is the most common cause of sexually transmitted infections globally and the leading cause of preventable blindness in the developing world. There are two biovariants of C...
  59. pmc Predicting phenotype and emerging strains among Chlamydia trachomatis infections
    Deborah Dean
    Children s Global Health Initiativ, Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Emerg Infect Dis 15:1385-94. 2009
    b>Chlamydia trachomatis is a global cause of blinding trachoma and sexually transmitted infections (STIs). We used comparative genomics of the family Chlamydiaceae to select conserved housekeeping genes for C...
  60. doi Prevalence of Chlamydia trachomatis: results from the first national population-based survey in France
    V Goulet
    Institut de Veille Sanitaire, 12 Rue du Val d Osne, Saint Maurice 94410, France
    Sex Transm Infect 86:263-70. 2010
    Few studies have estimated Chlamydia trachomatis (CT) prevalence in the general population, most prevalence studies being based on people already attending healthcare settings.
  61. ncbi The natural course of asymptomatic Chlamydia trachomatis infections: 45% clearance and no development of clinical PID after one-year follow-up
    Servaas A Morre
    Department of Pathology, Section of Molecular Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Int J STD AIDS 13:12-8. 2002
    The natural course of asymptomatic Chlamydia trachomatis infections in women was studied during one year in a cohort based nested case-control study...
  62. ncbi Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum
    Lynn Welter-Stahl
    Université Paris Denis Diderot, Institut Jacques Monod, 75251 Paris, France
    Cell Microbiol 8:1047-57. 2006
    Infection of epithelial cells by the intracellular pathogen, Chlamydia trachomatis, leads to activation of NF-kappaB and secretion of pro-inflammatory cytokines...
  63. pmc Chlamydia trachomatis induces remodeling of the actin cytoskeleton during attachment and entry into HeLa cells
    Reynaldo A Carabeo
    Host Parasite Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 70:3793-803. 2002
    To elucidate the host cell machinery utilized by Chlamydia trachomatis to invade epithelial cells, we examined the role of the actin cytoskeleton in the internalization of chlamydial elementary bodies (EBs)...
  64. pmc Virulence determinants in the obligate intracellular pathogen Chlamydia trachomatis revealed by forward genetic approaches
    Bidong D Nguyen
    Department of Molecular Genetics and Microbiology, Center for Microbial Pathogenesis, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 109:1263-8. 2012
    b>Chlamydia trachomatis, a pathogen responsible for diseases of significant clinical and public health importance, remains poorly characterized because of its intractability to routine molecular genetic manipulation...
  65. pmc A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates
    Laszlo Kari
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Exp Med 208:2217-23. 2011
    Blinding trachoma is an ancient neglected tropical disease caused by Chlamydia trachomatis for which a vaccine is needed...
  66. ncbi Evidence for long-term cervical persistence of Chlamydia trachomatis by omp1 genotyping
    D Dean
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Infect Dis 182:909-16. 2000
    Recurrent Chlamydia trachomatis infections are common among sexually active women. Although recurrences with a new chlamydial serovar indicate reinfection, same-serovar recurrences may be due to persistence...
  67. pmc Toll-like receptor 2 activation by Chlamydia trachomatis is plasmid dependent, and plasmid-responsive chromosomal loci are coordinately regulated in response to glucose limitation by C. trachomatis but not by C. muridarum
    CATHERINE M O'CONNELL
    Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Infect Immun 79:1044-56. 2011
    ..We derived a plasmid-cured derivative of the human genital isolate Chlamydia trachomatis D/UW-3/Cx, strain CTD153, which also fails to activate TLR2, indicating this virulence phenotype is ..
  68. pmc Risk of cervical cancer associated with Chlamydia trachomatis antibodies by histology, HPV type and HPV cofactors
    Margaret M Madeleine
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Int J Cancer 120:650-5. 2007
    ..0-5.1), but not for the 4 types (C, F, H, and K) that were present at very low prevalence in this population. There was an increased risk of SCC, but not AC, associated with antibodies to C. trachomatis that was not serotype specific...
  69. pmc Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infection
    Wen Cheng
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Infect Immun 76:515-22. 2008
    b>Chlamydia trachomatis infection induces inflammatory pathologies in the upper genital tract, potentially leading to ectopic pregnancy and infertility in the affected women...
  70. pmc A predominant role for antibody in acquired immunity to chlamydial genital tract reinfection
    Sandra G Morrison
    Division of Infectious Diseases, Department of Medicine, University of Alabama, Birmingham 35294 0007, USA
    J Immunol 175:7536-42. 2005
    Acquired immunity to murine Chlamydia trachomatis genital tract reinfection has long been assumed to be solely dependent on cell-mediated immunity. However, in this study, we identify a previously unrecognized protective role for Ab...
  71. pmc Conjunctival expression of matrix metalloproteinase and proinflammatory cytokine genes after trichiasis surgery
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 51:3583-90. 2010
    ..Conjunctival swab samples were collected for bacterial culture, Chlamydia trachomatis PCR, and RNA isolation at 1 year...
  72. pmc Simplifying chlamydia testing: an innovative Chlamydia trachomatis testing approach using the internet and a home sampling strategy: population based study
    D P Novak
    Department of Public Health and Clinical Medicine, Family Medicine, University of Umea, SE 901 85 Umea, Sweden
    Sex Transm Infect 82:142-7; discussion 152-3. 2006
    To measure the coverage, gender distribution, and participants' prevalence of genital Chlamydia trachomatis infections using a new internet based self selective testing approach by means of home sampling in the general population in ..
  73. pmc Actin and intermediate filaments stabilize the Chlamydia trachomatis vacuole by forming dynamic structural scaffolds
    Yadunanda Kumar
    Department of Molecular Genetics and Microbiology and Center for Microbial Pathogenesis, Duke University Medical Center, Durham, NC 27710, USA
    Cell Host Microbe 4:159-69. 2008
    The obligate intracellular bacterial pathogen Chlamydia trachomatis replicates within a large vacuole or "inclusion" that expands as bacteria multiply but is maintained as an intact organelle...
  74. ncbi Multifunctional analysis of Chlamydia-specific genes in a yeast expression system
    Jennifer L Sisko
    Department of Molecular Genetics and Microbiology and Center for Microbial Pathogenesis, Duke University Medical Center, Durham, NC 27710, USA
    Mol Microbiol 60:51-66. 2006
    ..system to characterize proteins of unknown function from the obligate intracellular bacterial pathogen Chlamydia trachomatis. We have devised a homologous recombination-based cloning strategy to construct an ordered array of ..
  75. pmc A C. trachomatis cloning vector and the generation of C. trachomatis strains expressing fluorescent proteins under the control of a C. trachomatis promoter
    Herve Agaisse
    Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 8:e57090. 2013
    ..trachomatis developmental cycle. For instance, we show the feasibility of investigating the dynamics of inclusion fusion and interaction with host proteins and organelles by time-lapse video microscopy...
  76. pmc Conditional gene expression in Chlamydia trachomatis using the tet system
    Jason Wickstrum
    Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States of America
    PLoS ONE 8:e76743. 2013
    b>Chlamydia trachomatis is maintained through a complex bi-phasic developmental cycle that incorporates numerous processes that are poorly understood. This is reflective of the previous paucity of genetic tools available...
  77. pmc Bactericidal activity of first-choice antibiotics against gamma interferon-induced persistent infection of human epithelial cells by Chlamydia trachomatis
    Nathalie Reveneau
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 South 4th St, National Institutes of Health, Hamilton, MT 59840, USA
    Antimicrob Agents Chemother 49:1787-93. 2005
    b>Chlamydia trachomatis is responsible for clinically important chronic inflammatory diseases of humans, including trachoma and pelvic inflammatory disease...
  78. pmc Chlamydia trachomatis infection results in a modest pro-inflammatory cytokine response and a decrease in T cell chemokine secretion in human polarized endocervical epithelial cells
    Lyndsey R Buckner
    Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Cytokine 63:151-65. 2013
    The endocervical epithelium is a major reservoir for Chlamydia trachomatis in women, and genital infections are extended in their duration...
  79. pmc Chlamydia trachomatis inclusion membrane protein CT228 recruits elements of the myosin phosphatase pathway to regulate release mechanisms
    Erika I Lutter
    Host Parasite Interactions Section, Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Cell Rep 3:1921-31. 2013
    b>Chlamydia trachomatis replicates within a membrane-bound compartment termed an inclusion. The inclusion membrane is modified by the insertion of multiple proteins known as Incs...
  80. pmc Expression and targeting of secreted proteins from Chlamydia trachomatis
    Laura D Bauler
    Host Parasite Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Bacteriol 196:1325-34. 2014
    b>Chlamydia trachomatis is an obligate intracellular pathogen that replicates in a vacuole termed the inclusion...
  81. pmc Performance of the Cepheid CT/NG Xpert Rapid PCR Test for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae
    Charlotte A Gaydos
    Division of Infectious Diseases, Johns Hopkins Medicine, Baltimore, Maryland, USA
    J Clin Microbiol 51:1666-72. 2013
    Tests for Chlamydia trachomatis and Neisseria gonorrhoeae, which can provide results rapidly to guide therapeutic decision-making, offer patient care advantages over laboratory-based tests that require several days to provide results...
  82. ncbi Activation of the host cell proinflammatory interleukin-8 response by Chlamydia trachomatis
    Kerry R Buchholz
    Program in Infectious Diseases and Immunity, University of California, Berkeley, CA 94720, USA
    Cell Microbiol 8:1768-79. 2006
    ..trachomatis. We conclude that a C. trachomatis growth-dependent factor produced at mid-developmental stage induces IL-8 within the epithelial cell it infects through activation of host signalling pathways...
  83. pmc Autophagy restricts Chlamydia trachomatis growth in human macrophages via IFNG-inducible guanylate binding proteins
    Munir A Al-Zeer
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
    Autophagy 9:50-62. 2013
    ..Through their capacity to remodel classically nonfusogenic chlamydial inclusions and stimulate fusion with autophagosomes, hGBP1/2 disable a major chlamydial virulence mechanism and contribute to IFNG-mediated pathogen clearance...
  84. pmc Variants in toll-like receptor 1 and 4 genes are associated with Chlamydia trachomatis among women with pelvic inflammatory disease
    Brandie D Taylor
    Department of Epidemiology, University of Pittsburgh, PA 15213, USA
    J Infect Dis 205:603-9. 2012
    Toll-like receptors (TLRs) are involved in the innate immune response. We examined whether TLR variants are associated with Chlamydia trachomatis infection among women with pelvic inflammatory disease (PID).
  85. pmc Nod1, but not the ASC inflammasome, contributes to induction of IL-1β secretion in human trophoblasts after sensing of Chlamydia trachomatis
    P B Kavathas
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Mucosal Immunol 6:235-43. 2013
    b>Chlamydia trachomatis (Ct) is an obligate intracellular bacterial pathogen. Previously, we showed that infection of human trophoblast cells by Ct triggers the secretion of the pro-inflammatory cytokine, interleukin (IL)-1β...
  86. pmc Cytokinesis is blocked in mammalian cells transfected with Chlamydia trachomatis gene CT223
    Damir T Alzhanov
    Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA
    BMC Microbiol 9:2. 2009
    ..The inc gene CT223 is one of a sequential set of orfs that encode or are predicted to encode Inc proteins. CT223p is localized to the inclusion membrane in all tested C. trachomatis serovars...
  87. doi Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction
    Dagmar Heuer
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Chariteplatz 1, 10117 Berlin, Germany
    Nature 457:731-5. 2009
    The obligate intracellular bacterium Chlamydia trachomatis survives and replicates within a membrane-bound vacuole, termed the inclusion, which intercepts host exocytic pathways to obtain nutrients...
  88. pmc Performance of the GeneXpert CT/NG assay compared to that of the Aptima AC2 assay for detection of rectal Chlamydia trachomatis and Neisseria gonorrhoeae by use of residual Aptima Samples
    S D Goldenberg
    Centre for Clinical Infection and Diagnostics Research, Guy s and St Thomas NHS Foundation Trust and King s College, London, United Kingdom
    J Clin Microbiol 50:3867-9. 2012
    There are currently no commercially available molecular assays for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae in rectal swabs with regulatory approval...
  89. pmc Polymorphisms in inc proteins and differential expression of inc genes among Chlamydia trachomatis strains correlate with invasiveness and tropism of lymphogranuloma venereum isolates
    Filipe Almeida
    Infection Biology Laboratory, Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
    J Bacteriol 194:6574-85. 2012
    b>Chlamydia trachomatis is a human bacterial pathogen that multiplies only within an intracellular membrane-bound vacuole, the inclusion. C...
  90. pmc Chlamydia trachomatis control requires a vaccine
    Robert C Brunham
    University of British Columbia and the British Columbia Centre for Disease Control, Vancouver, Canada
    Vaccine 31:1892-7. 2013
    As the most common reported communicable disease in North America and Europe, Chlamydia trachomatis is the focus of concerted public health control efforts based on screening and treatment...
  91. ncbi Assessment of Chlamydia trachomatis, Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis, and Mycoplasma genitalium in semen and first void urine specimens of asymptomatic male partners of infertile couples
    R Gdoura
    Department of Microbiology and Research Laboratory Microorganismes et Pathologie Humaine, Habib Bourguiba Hospital, Sfax, Tunisia
    J Androl 29:198-206. 2008
    ..to compare semen and first void urine (FVU) specimens from asymptomatic infertile men for the detection of Chlamydia trachomatis, genital ureaplasma, and genital mycoplasma infections using in-house inhibitor-controlled polymerase ..
  92. ncbi Lysosome repair enables host cell survival and bacterial persistence following Chlamydia trachomatis infection
    Wandy L Beatty
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Microbiol 9:2141-52. 2007
    ..Strains of the trachoma biovar of Chlamydia trachomatis are released from the host cell without concomitant host cell death...
  93. ncbi An early event in the herpes simplex virus type-2 replication cycle is sufficient to induce Chlamydia trachomatis persistence
    Srilekha Deka
    Department of Microbiology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 0579, USA
    Cell Microbiol 9:725-37. 2007
    Epidemiological studies have demonstrated that co-infections of herpes simplex virus type 2 (HSV-2) and Chlamydia trachomatis occur in vivo. Data from a tissue culture model of C...
  94. pmc Protection of mice from a Chlamydia trachomatis vaginal infection using a Salicylidene acylhydrazide, a potential microbicide
    Anatoly Slepenkin
    Department of Pathology and Laboratory Medicine, University of California, Irvine, CA 92697 4800, USA
    J Infect Dis 204:1313-20. 2011
    ..INP0341 treated intravaginally pre- and postinoculation with 5 × 10(2) inclusion-forming units (IFUs) of Chlamydia trachomatis serovar D...
  95. pmc Response of Chlamydia trachomatis serovar E to iron restriction in vitro and evidence for iron-regulated chlamydial proteins
    J E Raulston
    Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill 27599 7290, USA
    Infect Immun 65:4539-47. 1997
    ..In this study, the effect of iron limitation was examined for the sexually transmitted infectious agent Chlamydia trachomatis in an in vitro model of human genital infection using the intracellular iron-chelating reagent ..
  96. ncbi Expression of Chlamydia trachomatis genes encoding products required for DNA synthesis and cell division during active versus persistent infection
    H C Gerard
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Gordon H Scott Hall, 540 East Canfield Ave, Detroit, MI 48201, USA
    Mol Microbiol 41:731-41. 2001
    During persistent infection, the intracellular bacterial pathogen Chlamydia trachomatis is viable but severely attenuates the production of new, infectious elementary bodies (EBs)...
  97. pmc Tryptophan depletion as a mechanism of gamma interferon-mediated chlamydial persistence
    W L Beatty
    Department of Medical Microbiology and Immunology, University of Wisconsin, Madison 53706
    Infect Immun 62:3705-11. 1994
    ..interferon (IFN-gamma) activates host cells to restrict intracellular growth of the bacterial pathogen Chlamydia trachomatis by induction of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO)...
  98. pmc In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance
    Andrea J McCoy
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    J Bacteriol 185:1218-28. 2003
    ..The murA gene from Chlamydia trachomatis serovar L2 was cloned and placed under the control of the arabinose-inducible, glucose-repressible ara ..
  99. ncbi Chlamydia outer membrane protein discovery using genomics
    R S Stephens
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California 94720, USA
    Curr Opin Microbiol 4:16-20. 2001
    ..Several of the predicted outer membrane proteins recently have been shown to be translated and localized to the surface of the chlamydial outer membrane...
  100. pmc Pesky trachoma suspect finally caught
    K Miller
    F I Proctor Foundation, University of California San Francisco, USA
    Br J Ophthalmol 88:750-1. 2004
    Face seeking flies have long been thought to transmit Chlamydia trachomatis, the causative agent of trachoma, but this has never been proven...
  101. pmc Long term outcome of trichiasis surgery in the Gambia
    M J Burton
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Br J Ophthalmol 89:575-9. 2005
    ..There are limited data on the long term outcome of surgery and its effect on vision and corneal opacification. Similarly, the determinants of failure are not well understood...

Research Grants75

  1. The role of novel, uncultivable bacteria in incident PID
    CATHERINE L contact HAGGERTY; Fiscal Year: 2011
    ..Although Chlamydia trachomatis and Neisseria gonorrhoeae are commonly associated with PID, the etiology of up to 70% of cases is unknown...
  2. A Rapid Point-of-care Diagnostic for Neisseria gonorrhoeae STDs
    Richard F Selden; Fiscal Year: 2012
    ..target genome that would effectively render the pathogens invisible (as was recently seen a major European Chlamydia trachomatis strain), incapable of strain typing (making reliable epidemiology studies and contact tracing impossible), ..
  3. A Rapid Point-of-care Diagnostic for C.trachomitis STDs
    RICHARD F contact SELDEN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Improved diagnoses of Chlamydia trachomatis infections represent a critical unmet medical need. C...
  4. Enzymology of Chlamydia Pathogenesis
    Dewey G McCafferty; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The obligate intracellular bacterium Chlamydia trachomatis is the most common sexually-transmitted pathogen in the developed world, >100 million persons are infected worldwide annually. C...
  5. A Rapid Point-of-care Diagnostic for C. trachomatis STDs
    Richard F Selden; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Improved diagnosis of Chlamydia trachomatis (Ct) infections represents a critical unmet medical need...
  6. The influence of negative regulators of inflammation on C. trachomatis infections
    DAVID MARCELO OJCIUS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Chlamydia trachomatis (CT) is the leading bacterial cause of sexually-transmitted diseases (STD) in humans worldwide. Inflammation is required for elimination of chlamydial infection...
  7. C. trachomatis-mediated signaling pathways required for Type I IFN responses
    JEFFREY RYAN BARKER; Fiscal Year: 2013
    ..b>Chlamydia trachomatis induces a potent Type I IFN response in many different cell types that is dependent on multiple pattern ..
  8. Validating metabolic pathways in the intracellular pathogen Chlamydia trachomatis
    DEREK JAMES FISHER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Chlamydia trachomatis is the leading cause of preventable blindness (~8 million visually impaired people worldwide) and bacteria-associated sexually transmitted diseases (STD) with over 900,000 ..
  9. Functional Characterization of CXCL14, CXCL17, and CCL28; three mucosal chemokine
    Albert Zlotnik; Fiscal Year: 2010
    ..We will test several microorganisms, including gram (+), gram (-), Candida albicans and Chlamydia trachomatis. If confirmed, this result would indicate that these chemokines may be major players in maintaining the ..
  10. Development of a Chlamydia T Cell Vaccine Based on Dendritic Cell Immunoprotemics
    Leonard J Foster; Fiscal Year: 2012
    ..8 million infections in America alone. Chlamydia trachomatis can cause pelvic inflammatory disease, ectopic pregnancy and infertility in women and is a co- factor in ..
  11. Novel Bacterial Pathogens in Pelvic Inflammatory Disease
    Catherine L Haggerty; Fiscal Year: 2012
    ..Although Neisseria gonorrhoeae and/or Chlamydia trachomatis are recovered from approximately a third to a half of women with PID, in the other women the etiologic ..
  12. HAART optimism, drug use and risky sexual behavior among MSM in British Columbia.
    Robert Stephen Hogg; Fiscal Year: 2013
    ..gonnorhea and Chlamydia trachomatis and to provide consent to allow researchers access to health services databases in the province...
  13. The interaction of Chlamydia with the host cytoskeleton
    Scott S Grieshaber; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The obligate intracellular bacterium Chlamydia trachomatis is the world's leading cause of preventable blindness and the most common sexually transmitted bacterial pathogen of humans...
  14. Recombination and Genetics in Chlamydia spp.
    Daniel D Rockey; Fiscal Year: 2010
    ..Infections by Chlamydia trachomatis and C...
  15. Rapid and Cost-Effective Diagnostic System for Sexually Transmitted Infections
    John E Mueller; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): According to the CDC, chlamydia and gonorrhea, caused by Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG), respectively, are the first and second most frequently reported STIs in the US and ..
  16. Factors Mediating Host Resistance to Chlamydia trachomatis
    Michael N Starnbach; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Infection with Chlamydia trachomatis is responsible for significant morbidity throughout the world. Chronic genital infections with C...
  17. CHARACTERIZATION OF A NOVEL HOST PATHWAY THAT REGULATES CHLAMYDIAL DEVELOPMENT
    Robert V Schoborg; Fiscal Year: 2013
    ..9 billion dollars in the US in 2000. Genital Chlamydia trachomatis (2,800,000 new cases/year) and Herpes Simplex Virus type 2 (HSV-2;200- 500,000 new cases/year + <40 ..
  18. Computerized Counseling to Promote Positive Prevention and HIV Health in Kenya
    Ann Elizabeth Kurth; Fiscal Year: 2012
    ..risk will be measured by self-reported unprotected sex with HIV- negative/unknown partner, and trends in Chlamydia trachomatis, Neisseria gonorrhoeae, and T. vaginalis...
  19. Cervical Maturity, Mucosal Immunity, and Chlamydia trachomatis infection
    Loris Y Hwang; Fiscal Year: 2012
    ..1) to conduct clinical translational research on cervical epithelial maturity, mucosal immunity, and Chlamydia trachomatis infection in adolescents;2) to gain knowledge of basic and mucosal immunology;3) to gain practical ..
  20. T-bet regulates CD4 memory to bacterial infection with C. trachomatis
    David Gondek; Fiscal Year: 2010
    b>Chlamydia trachomatis is the most prevalent sexually transmitted bacterial infection in the US and the primary cause of preventable blindness worldwide...
  21. In vivo observations of transcription at single-nucleotide resolution
    MATTHEW HERBERT LARSON; Fiscal Year: 2013
    ..pylori) and Chlamydia trachomatis (C...
  22. Effects of a chlamydial ATP-consuming enzyme on the inflammasome
    MARIA LUISA AVILA; Fiscal Year: 2010
    b>Chlamydia trachomatis is the leading bacterial cause of sexually transmitted diseases in humans worldwide...
  23. Mechanism(s) of CD8 T cell-mediated Chlamydia-induced reproductive pathology
    ASHLESH KRISHNA MURTHY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Sexually transmitted diseases caused by Chlamydia trachomatis, an intracellular bacterial pathogen, affect approximately 90 million people worldwide...
  24. T-cell mediated immunity in chlamydia genital infection
    Kathleen A Kelly; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Chlamydia trachomatis, an obligate intracellular bacterium, causes the most cases of bacterial sexually transmitted infections (STIs)...
  25. A Point of Care, Nucleic Acid Test for Chlamydia to Ensure Prompt Treatment of He
    LAURA T MAZZOLA; Fiscal Year: 2013
    ..populations are the most impacted by sexually transmitted diseases (STDs), most commonly infections by Chlamydia trachomatis (CT)...
  26. Development of an in vivo model of chlamydial persistence.
    Robert V Schoborg; Fiscal Year: 2010
    b>Chlamydia trachomatis, the most common bacterial sexually transmitted disease (STD) agent worldwide, often establishes asymptomatic genital infections which result in serious reproductive complications...
  27. Peptide Deformylase Inhibitor LBM415 for Sexually Transmitted Infections
    Huizhou Fan; Fiscal Year: 2011
    ..b>Chlamydia trachomatis and Neisseria gonorrhoeae are the most common sexually transmitted pathogens...
  28. Synthetic Models and Spectroscopy of Metal-Oxo Proteins
    Lawrence Que; Fiscal Year: 2013
    ..ribonucleotide reductase (RNR) with a FeMn active site (instead of a diiron site) from the parasite Chlamydia trachomatis. Understanding the difference in the reactivity properties of high-valent FeFe and FeMn complexes may ..
  29. Evaluation of CPAF Mediated Anti-Chlamydial Immunity in the Guinea Pig
    BERNARD PRAGASH ARULANANDAM; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Chlamydia trachomatis is the leading cause of bacterial sexually transmitted disease worldwide...
  30. Scanning Chlamydia proteome for vaccine antigens
    Luis M de la Maza; Fiscal Year: 2010
    Throughout the World Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen. In areas with poor sanitary conditions C. trachomatis causes trachoma the most common cause of preventable blindness in the World...
  31. Trapping membrane proteins with adjuvant-carrying amphipols for vaccine formulati
    Luis M de la Maza; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chlamydia trachomatis infections are widespread throughout the World...
  32. Nested case-control study of maternal herpes viruses in relation to gastroschisis
    Martha M Werler; Fiscal Year: 2013
    ..epidemiologic profile of gastroschisis: Epstein-Barr virus, herpes simplex virus 2, cytomegalovirus, and Chlamydia trachomatis. However, a clear biological mechanism through which these infectious agents could disrupt fetal ..
  33. MHC-Ib restricted T cell responses against Listeria monocytogenes
    SARAH E F D apos ORAZIO; Fiscal Year: 2010
    ..studies have the potential to lead to new therapeutic strategies to protect against infections with a variety of intracellular bacteria, including prevalent human pathogens such as Mycobacteria tuberculosis and Chlamydia trachomatis.
  34. Biodegradable Nanoparticles for Targeted Antibiotic Delivery
    Judith A Whittum-Hudson; Fiscal Year: 2012
    Human infections by the intracellular bacterial pathogens Chlamydia trachomatis and C pneumoniae present an enormous health care problem...
  35. 12th International Symposium on Human Chlamydial Infections
    Julius Schachter; Fiscal Year: 2010
    ..b>Chlamydia trachomatis infections are the most common bacterial cause of sexually transmitted diseases often resulting in severe ..
  36. 18F-Fallypride Micropet Imaging to Monitor Pancreatic Beta Cell Loss in Diabetes
    Adriana Garcia; Fiscal Year: 2010
    ..treated CR-EAE in DA rats, and at therapeutic concentrations did not compromise the immune response to chlamydia trachomatis. These data have been submitted for publication...
  37. Mycoplasma Genitalium and Pelvic Inflammatory Disease
    Catherine L Haggerty; Fiscal Year: 2010
    ..genitalium or Chlamydia trachomatis. M...
  38. INDUCTION OF PROTECTIVE IMMUNITY AGAINST CHLAMYDIA
    Francis O Eko; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chlamydia trachomatis, composed of 15 odd serovars (A through K and L1 to L3) with serovars D through K and the lymphogranuloma venereum strains L1 - L3 causing sexually transmitted diseases (STDs), ..
  39. Anti-adhesive prevention of Chlamydia trachomatis genital tract infection
    Lee Ann Campbell; Fiscal Year: 2010
    Sexually transmitted infections (STIs) have a huge impact on public health. Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections globally, and is the most prevalent sexually transmitted diseases in the ..
  40. SOUTH AFRICAN ADOLESCENT HEALTH PROMOTION PROJECT
    JOHN BARTON JEMMOTT; Fiscal Year: 2010
    ..Urine specimens will be collected and tested for Chlamydia trachomatis, Neisseria gonorrhea, and Trichomonas vaginalis using DNA-amplification technology...
  41. Multiplex diagnostic for biothreat C. psittaci &non-threat respiratory pathogens
    Richard F Selden; Fiscal Year: 2013
    ..the leading cause of atypical pneumonia and often confused with biothreat agents in clinical presentation: Chlamydia trachomatis (Ct), Chlamydia pneumoniae (Cpn), Mycoplasma pneumoniae (Mp) and Legionella pneumophila (Lp)...
  42. Mechanism of Chlamydia-induced centrosome amplification
    Ming Tan; Fiscal Year: 2010
    Chlamydia infections are the most commonly reported infectious disease in the U.S. Chlamydia trachomatis is the most common cause of bacterial sexually transmitted infection, and it has been associated with cervical cancer, both as an ..
  43. TLR2 ligands of chlamydiae
    CATHERINE M O apos CONNELL; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Chlamydia trachomatis infections are the leading cause of involuntary infertility and ectopic pregnancy in women...
  44. Transcriptional Control of Chlamydial Development
    Robert J Belland; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Chlamydia trachomatis is the leading cause of preventable blindness in developing countries and the most commonly reported sexually transmitted infection worldwide...
  45. Novel ways to prevent upper GT infection
    Kathleen A Kelly; Fiscal Year: 2013
    ..We chose infection by the pathogen, Chlamydia trachomatis, which relies on Th1 mucosal immune responses for elimination, is a significant burden on health care, and ..
  46. CPAF induced CD4+ T cell mediated immunity against Chlamydia
    BERNARD PRAGASH ARULANANDAM; Fiscal Year: 2013
    Project Summary There currently is no licensed vaccine against Chlamydia trachomatis, the leading cause of bacterial sexually transmitted disease worldwide...
  47. The Elimination of Health Disparities through Translation Research
    Carol E Kaufman; Fiscal Year: 2010
    ..In fact, 11 of the 12 service areas of the Indian Health Service (IHS) show rates of Chlamydia trachomatis (Chlamydia) higher than the US average, with 3 of these service areas at levels 5-6 times higher...
  48. Novel approaches to identify host genes required for Chlamydia pathogenesis
    Joanne N Engel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chlamydia trachomatis and C. pneumoniae are important causes of human infections and disease. C...
  49. Six new Chlamydia epitopes
    DAVID EMMET NELSON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chlamydia trachomatis is the most common bacterial sexually transmitted disease in the developed world with a prevalence approaching 10% in adolescents and young adults. In women C...
  50. Evaluation of a subunit Chlamydia trachomatis vaccine in Rhesus Macaques
    Luis M de la Maza; Fiscal Year: 2011
    b>Chlamydia trachomatis (CT) infections are widespread throughout the World...
  51. A Multiplex Point-of-Care Test for Vaginal Infections
    Matthew Steele; Fiscal Year: 2010
    ..of an integrated parallel (NA) amplification lab-on-a-card diagnostic for the rapid identification of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and bacteria specific for bacterial vaginosis individually ..
  52. Origin of Repeat Bacterial STIS Among Heterosexual Men
    Patricia J Kissinger; Fiscal Year: 2012
    ..provided by applicant): Recent reports of an increase in possible treatment failure of azithromycin for Chlamydia trachomatis (Ct) and Mycoplasma genitalium (Mg) call for a better understanding of the origin of these repeat ..
  53. Chlamydia trachomatis proteomics
    Guangming Zhong; Fiscal Year: 2013
    ..trachomatis protective &pathogenic determinants. Chlamydia trachomatis urogenital tract infection causes inflammatory pathologies in the upper genital tract, which can lead to ..
  54. Development of Genetic techniques in Chlamydia
    Karl E Klose; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chlamydia trachomatis causes ocular and genital infections in humans, which can lead to blindness and infertility...
  55. San Antonio STI TM CRC
    JOEL BARRY BASEMAN; Fiscal Year: 2010
    ..b>Chlamydia trachomatis, Trichomonas vaginalis, and Mycoplasma genitalium are the emphasized STI agents although correlations with ..
  56. Heterogeneity in Cytokine Responses to HIV-1 Infection
    Jianming Tang; Fiscal Year: 2011
    ..can be analyzed for genetic associations with sexually transmitted infections due to two other agents (Chlamydia trachomatis and herpes simplex virus type 2) commonly seen in the adolescent cohort...
  57. At Risk Hispanic Gangs: Long-Term Consequences for Hiv, Hepatitis and STI
    Avelardo Valdez; Fiscal Year: 2011
    ..Determine the prevalence (tested) of HIV, HBV, HCV, and STIs, (chlamydia trachomatis, syphilis and herpes simplex virus-2) infection in young adulthood (n=310). 2...
  58. Eco-Pathogenomics of Chlamydial Reproductive Tract Infection (EPCRTI)
    Jacques Ravel; Fiscal Year: 2013
    ..infection by invasive non-indigenous organisms that cause disease, such as the sexually transmitted Chlamydia trachomatis. Despite their importance, surprisingly little is known about the composition and dynamics of vaginal ..
  59. Mechanisms and Correlates of Immune Protection against Genital Chlamydia in Human
    William M Geisler; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chlamydia trachomatis (CT) infection is the most prevalent bacterial sexually transmitted infection, and infection rates are highest in African Americans...
  60. Immunomodulation and Vaccine Optimization against Chlamydia
    Qing He; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chlamydia trachomatis is a major infectious bacterial agent that causes sexually transmitted disease (STD) worldwide...
  61. CYTOTOXIC T CELL MEDIATED IMMUNITY TO CHLAMYDIA
    Michael N Starnbach; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Infection with Chlamydia trachomatis is responsible for significant morbidity throughout the world. Work from our lab suggests that T cells are a key mediator of immune protection against C...
  62. Identifying Biomarkers and Genetic Risk Factors Predictive of Reproductive Sequel
    Toni Darville; Fiscal Year: 2013
    ..of this proposal: (1) Identify the local inflammatory and fibrotic pathways most strongly regulated during Chlamydia trachomatis infection by performing microarray-based analysis of RNA isolated from endometrial tissue biopsies ..
  63. Clinical Epidemiology of Mycoplasma genitalium
    Patricia Totten; Fiscal Year: 2006
    ..syndromes remain idiopathic, not attributable to the major sexually transmitted pathogens such as Chlamydia trachomatis or Neisseria gonorrhoeae...
  64. CHLAMYDIA TRACHOMATIS ENVELOPE COMPONENTS AND VIRULENCE
    JANE RAULSTON; Fiscal Year: 2003
    b>Chlamydia trachomatis is the leading bacterial agent of sexually transmitted infections in the United States and a major culprit in urethritis, cervicitis, endometritis, salpingitis, pelvic inflammatory disease, infertility and ectopic ..
  65. Can Chlamydial Infection Increase Host Mutation Frequency?
    ROBERT SCHOBORG; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The bacterium Chlamydia trachomatis is a common sexually transmitted disease agent, with 4,000,000 new cases/year in the US. C...
  66. Combination Antibotics as a Treatment for Chlamydia-Induced Reactive Arthritis
    John Carter; Fiscal Year: 2007
    ..b>Chlamydia trachomatis (Ct) is a known trigger for ReA...
  67. RECOMBINANT POLYTYPIC CHLAMYDIA VACCINE
    LUIS DE LA MAZA; Fiscal Year: 1991
    The objective of this proposal is to develop a recombinant polytypic vaccine for Chlamydia trachomatis infections. C...
  68. INFECTIOUS ETIOLOGY TESTICULAR CANCER
    Loren Lipworth; Fiscal Year: 2000
    ..we propose to evaluate the association between antibody response to HSV-2, HPV-16 and 15, HHV-8 and Chlamydia trachomatis on the one hand and the occurrence of testicular cancer on the other...
  69. A High Accuracy Point-of-Care Chlamydia trachomatis Test
    Michael Helms; Fiscal Year: 2004
    Urogenital disease caused by Chlamydia trachomatis (Ct) is a major public health problem affecting 3-4 million people in the U.S. and over 100 million worldwide annually...
  70. HIV AND STIS IN YOUNG ADULTS: A NETWORK APPROACH
    W Morris; Fiscal Year: 2003
    ..Specimens will be tested for four STIs in Survey 2000: Chlamydia trachomatis (Ct), Neisseria gonorrhea (GC), Trichomonas vaginalis (Tv), and human immunodeficiency virus (HIV)...
  71. Urinary Symptoms in Adolescent Females: STI or UTI?
    Jill Huppert; Fiscal Year: 2004
    ..adolescents constitute the age group at highest risk for STIs, the CDC recommends annual screening for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) in all sexually active (SA) adolescents, regardless of symptoms...
  72. Chaperone Mining of the Chlamydia Type Three Secretion System
    ELLENA MARIE PETERSON; Fiscal Year: 2010
    b>Chlamydia trachomatis is a leading cause of sexually transmitted diseases...
  73. Targeted Genetic Modifications of Chlamydia Trachomatis
    ROBERT DE MARS; Fiscal Year: 2004
    b>Chlamydia trachomatis is the most common cause of bacterial sexually transmitted disease and of preventable blindness in humans...
  74. Rapid Point-of-Care Diagnostic Test for Chlamydia and Gonorrhea
    DAVID DOLINGER; Fiscal Year: 2007
    ..a rapid, point-of-care (POC), nucleic acid amplification based diagnostic test for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae using our innovative "Lab-in-a-tube" (LiatTM) technology...
  75. IMMUNOPATHOLOGY OF CHLAMYDIA--INDUCED REACTIVE ARTHRITIS
    Roger Rank; Fiscal Year: 1991
    ..Yersinia enterocolitica, Salmonella, Shigella, and Campylobacter and from genital tract infections with Chlamydia trachomatis. Despite a knowledge of the association of these bacteria with reactive arthritis, little is known of the ..