chlamydia

Summary

Summary: A genus of the family CHLAMYDIACEAE whose species cause a variety of diseases in vertebrates including humans, mice, and swine. Chlamydia species are gram-negative and produce glycogen. The type species is CHLAMYDIA TRACHOMATIS.

Top Publications

  1. pmc Chlamydia persistence -- a tool to dissect chlamydia--host interactions
    R V Schoborg
    Department of Microbiology, East Tennessee State University, James H Quillen College of Medicine, Johnson City, TN 37614 1708, USA
    Microbes Infect 13:649-62. 2011
  2. pmc Inclusion membrane proteins of Protochlamydia amoebophila UWE25 reveal a conserved mechanism for host cell interaction among the Chlamydiae
    Eva Heinz
    University of Vienna, Department of Microbial Ecology, Althanstrasse 14, A 1090 Vienna, Austria
    J Bacteriol 192:5093-102. 2010
  3. pmc Chlamydial persistence: beyond the biphasic paradigm
    Richard J Hogan
    Infectious Diseases Program and Cooperative Research Centre for Diagnostics, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Infect Immun 72:1843-55. 2004
  4. pmc The lipid transfer protein CERT interacts with the Chlamydia inclusion protein IncD and participates to ER-Chlamydia inclusion membrane contact sites
    Isabelle Derre
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 7:e1002092. 2011
  5. pmc Asymptomatic endemic Chlamydia pecorum infections reduce growth rates in calves by up to 48 percent
    Anil Poudel
    Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, United States of America
    PLoS ONE 7:e44961. 2012
  6. doi Selection for tetracycline-resistant Chlamydia suis in treated pigs
    Nicole Borel
    Institute for Veterinary Pathology, University of Zurich, Vetsuisse Faculty, Winterthurerstrasse 268, CH 8057 Zurich, Switzerland
    Vet Microbiol 156:143-6. 2012
  7. pmc Horizontal transfer of tetracycline resistance among Chlamydia spp. in vitro
    R J Suchland
    Division of Allergy and Infectious Disease, Department of Medicine, University of Washington, Seattle, Washington, USA
    Antimicrob Agents Chemother 53:4604-11. 2009
  8. ncbi Prevalence of rectal, urethral, and pharyngeal chlamydia and gonorrhea detected in 2 clinical settings among men who have sex with men: San Francisco, California, 2003
    Charlotte K Kent
    Department of Public Health, San Francisco, California, USA
    Clin Infect Dis 41:67-74. 2005
  9. ncbi The chlamydial developmental cycle
    Yasser M Abdelrahman
    Department of Molecular Sciences, University of Tennessee Health Sciences Center, 858 Madison Avenue, Memphis, TN 38163, USA
    FEMS Microbiol Rev 29:949-59. 2005
  10. pmc Chlamydia species-dependent differences in the growth requirement for lysosomes
    Scot P Ouellette
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College, London, United Kingdom
    PLoS ONE 6:e16783. 2011

Detail Information

Publications319 found, 100 shown here

  1. pmc Chlamydia persistence -- a tool to dissect chlamydia--host interactions
    R V Schoborg
    Department of Microbiology, East Tennessee State University, James H Quillen College of Medicine, Johnson City, TN 37614 1708, USA
    Microbes Infect 13:649-62. 2011
    ..This review will discuss examples of: i) persistence studies that have illuminated critical chlamydiae/host interactions; and ii) novel persistence models that will do so in the future...
  2. pmc Inclusion membrane proteins of Protochlamydia amoebophila UWE25 reveal a conserved mechanism for host cell interaction among the Chlamydiae
    Eva Heinz
    University of Vienna, Department of Microbial Ecology, Althanstrasse 14, A 1090 Vienna, Austria
    J Bacteriol 192:5093-102. 2010
    ..amoebophila shows that this strategy for host cell interaction is conserved among the chlamydiae and is used by chlamydial symbionts and pathogens alike...
  3. pmc Chlamydial persistence: beyond the biphasic paradigm
    Richard J Hogan
    Infectious Diseases Program and Cooperative Research Centre for Diagnostics, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Infect Immun 72:1843-55. 2004
  4. pmc The lipid transfer protein CERT interacts with the Chlamydia inclusion protein IncD and participates to ER-Chlamydia inclusion membrane contact sites
    Isabelle Derre
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 7:e1002092. 2011
    ..recruited to the inclusion, a membrane-bound compartment harboring the obligate intracellular pathogen Chlamydia trachomatis...
  5. pmc Asymptomatic endemic Chlamydia pecorum infections reduce growth rates in calves by up to 48 percent
    Anil Poudel
    Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, United States of America
    PLoS ONE 7:e44961. 2012
    Intracellular Chlamydia (C.) bacteria cause in cattle some acute but rare diseases such as abortion, sporadic bovine encephalomyelitis, kerato-conjunctivitis, pneumonia, enteritis and polyarthritis...
  6. doi Selection for tetracycline-resistant Chlamydia suis in treated pigs
    Nicole Borel
    Institute for Veterinary Pathology, University of Zurich, Vetsuisse Faculty, Winterthurerstrasse 268, CH 8057 Zurich, Switzerland
    Vet Microbiol 156:143-6. 2012
    The aim of this study was to investigate Chlamydia suis in a pig farm with an outbreak of conjunctivitis and diarrhea. Eye swabs and pooled fecal samples were investigated for the presence of C...
  7. pmc Horizontal transfer of tetracycline resistance among Chlamydia spp. in vitro
    R J Suchland
    Division of Allergy and Infectious Disease, Department of Medicine, University of Washington, Seattle, Washington, USA
    Antimicrob Agents Chemother 53:4604-11. 2009
    There are no examples of stable tetracycline resistance in clinical strains of Chlamydia trachomatis. However, the swine pathogen Chlamydia suis is commonly tetracycline resistant, both in America and in Europe. In tested U.S...
  8. ncbi Prevalence of rectal, urethral, and pharyngeal chlamydia and gonorrhea detected in 2 clinical settings among men who have sex with men: San Francisco, California, 2003
    Charlotte K Kent
    Department of Public Health, San Francisco, California, USA
    Clin Infect Dis 41:67-74. 2005
    The Centers for Disease Control and Prevention developed screening and diagnostic testing guidelines for chlamydia and gonorrhea at urethral, rectal, and pharyngeal sites for men who have sex with men (MSM)...
  9. ncbi The chlamydial developmental cycle
    Yasser M Abdelrahman
    Department of Molecular Sciences, University of Tennessee Health Sciences Center, 858 Madison Avenue, Memphis, TN 38163, USA
    FEMS Microbiol Rev 29:949-59. 2005
    ..Measuring transcriptional changes throughout the cycle has allowed investigators to determine the nature of the temporal gene expression changes required for bacterial growth and development...
  10. pmc Chlamydia species-dependent differences in the growth requirement for lysosomes
    Scot P Ouellette
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College, London, United Kingdom
    PLoS ONE 6:e16783. 2011
    Genome reduction is a hallmark of obligate intracellular pathogens such as Chlamydia, where adaptation to intracellular growth has resulted in the elimination of genes encoding biosynthetic enzymes...
  11. pmc Multilocus sequence analysis provides insights into molecular epidemiology of Chlamydia pecorum infections in Australian sheep, cattle, and koalas
    Martina Jelocnik
    Institute for Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    J Clin Microbiol 51:2625-32. 2013
    b>Chlamydia pecorum is a significant pathogen of domestic livestock and wildlife. We have developed a C...
  12. ncbi Animal chlamydioses and zoonotic implications
    D Longbottom
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    J Comp Pathol 128:217-44. 2003
  13. doi Divergence without difference: phylogenetics and taxonomy of Chlamydia resolved
    Richard S Stephens
    University of California, Berkeley, USA
    FEMS Immunol Med Microbiol 55:115-9. 2009
    ..consistent with the natural history of the organism revealed by genome comparisons, nor widely used by the Chlamydia research community 8 years after its introduction; thus, it is proposed to reunite the Chlamydiaceae into a ..
  14. doi Functional conservation of the lipid II biosynthesis pathway in the cell wall-less bacteria Chlamydia and Wolbachia: why is lipid II needed?
    Beate Henrichfreise
    Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany
    Mol Microbiol 73:913-23. 2009
    ..Genes for enzymes of both machineries have been found in the genomes of the cell wall-less genera Chlamydia and Wolbachia, raising questions as to the functionality of the lipid II biosynthesis pathway and reasons for ..
  15. pmc The chlamydial plasmid-encoded protein pgp3 is secreted into the cytosol of Chlamydia-infected cells
    Zhongyu Li
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Infect Immun 76:3415-28. 2008
    ..We found that the pORF5 protein (also known as pgp3) was detected mainly in the cytosol of Chlamydia-infected cells, while the remaining seven proteins were found inside the chlamydial inclusions only...
  16. pmc New insights into Chlamydia intracellular survival mechanisms
    Jordan L Cocchiaro
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA
    Cell Microbiol 11:1571-8. 2009
    b>Chlamydia sp. are responsible for a wide range of diseases of significant clinical and public health importance...
  17. pmc RNAi screen in Drosophila cells reveals the involvement of the Tom complex in Chlamydia infection
    Isabelle Derre
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA
    PLoS Pathog 3:1446-58. 2007
    b>Chlamydia spp. are intracellular obligate bacterial pathogens that infect a wide range of host cells. Here, we show that C. caviae enters, replicates, and performs a complete developmental cycle in Drosophila SL2 cells...
  18. ncbi Chlamydia outer membrane protein discovery using genomics
    R S Stephens
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California 94720, USA
    Curr Opin Microbiol 4:16-20. 2001
    ..Several of the predicted outer membrane proteins recently have been shown to be translated and localized to the surface of the chlamydial outer membrane...
  19. pmc Mixed infections with Chlamydia and porcine epidemic diarrhea virus - a new in vitro model of chlamydial persistence
    Nicole Borel
    Institute of Veterinary Pathology, University of Zurich, Switzerland
    BMC Microbiol 10:201. 2010
    ..Mixed infections with Chlamydia and porcine epidemic diarrhea virus (PEDV) may result in generation of persistent chlamydial infections...
  20. pmc Trends in chlamydia and gonorrhea positivity among heterosexual men and men who have sex with men attending a large urban sexual health service in Australia, 2002-2009
    Lenka A Vodstrcil
    Melbourne School of Population Health, The University of Melbourne, Vic, Australia
    BMC Infect Dis 11:158. 2011
    To determine whether chlamydia positivity among heterosexual men (MSW) and chlamydia and gonorrhea positivity among men who have sex with men (MSM), are changing.
  21. doi Recent advances in understanding the biology, epidemiology and control of chlamydial infections in koalas
    Adam Polkinghorne
    Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane 4059, Australia
    Vet Microbiol 165:214-23. 2013
    ..and long-term viability of affected populations is disease caused by the obligate intracellular bacteria, Chlamydia. Two chlamydial species infect the koala, Chlamydia pecorum and Chlamydia pneumoniae, and have been reported in ..
  22. doi An alternative menaquinone biosynthetic pathway operating in microorganisms: an attractive target for drug discovery to pathogenic Helicobacter and Chlamydia strains
    Tohru Dairi
    Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan
    J Antibiot (Tokyo) 62:347-52. 2009
    ..As humans and some useful intestinal bacteria, such as lactobacilli, lack the alternative pathway, it would be an attractive target for the development of chemotherapeutics...
  23. doi Tetracycline-resistant Chlamydia suis in cases of reproductive failure on Belgian, Cypriote and Israeli pig production farms
    Katelijn Schautteet
    Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Med Microbiol 62:331-4. 2013
    Similar cases of severe reproductive failure associated with the presence of Chlamydia suis in two Belgian, one Cypriote and one Israeli pig farrowing to slaughter farms are presented...
  24. pmc Lipid acquisition by intracellular Chlamydiae
    Cherilyn A Elwell
    Departments of Medicine, University of California, San Francisco, CA, USA
    Cell Microbiol 14:1010-8. 2012
    b>Chlamydia species are obligate intracellular pathogens that are important causes of human genital tract, ocular and respiratory infections...
  25. pmc Mechanisms of host cell exit by the intracellular bacterium Chlamydia
    Kevin Hybiske
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 104:11430-5. 2007
    ..The release pathway of the obligate intracellular bacterium Chlamydia from cells is unknown...
  26. pmc Acquisition of nutrients by Chlamydiae: unique challenges of living in an intracellular compartment
    Hector Alex Saka
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Opin Microbiol 13:4-10. 2010
    ....
  27. ncbi Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease
    Jay C Horvat
    Priority Research Centre for Asthma and Respiratory Disease, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Newcastle, Australia
    Am J Respir Crit Care Med 176:556-64. 2007
    ..Chlamydial lung infection has been associated with asthma in children and adults. However, how chlamydial infection influences the development of immune responses that promote asthma remains unknown...
  28. pmc Sequence-based prediction of type III secreted proteins
    Roland Arnold
    Department of Genome Oriented Bioinformatics, Technische Universitat Munchen, Wissenschaftszentrum Weihenstephan, Freising, Germany
    PLoS Pathog 5:e1000376. 2009
    ..Our findings will facilitate further studies on and improve our understanding of type III secretion and its role in pathogen-host interactions...
  29. doi Aberrant chlamydial developmental forms in the gastrointestinal tract of pigs spontaneously and experimentally infected with Chlamydia suis
    Andreas Pospischil
    Institute of Veterinary Pathology, University of Zurich, Vetsuisse Faculty, Winterthurerstrasse 268, CH 8057 Zurich, Switzerland
    Vet Microbiol 135:147-56. 2009
    ..Intestinal tissues derived from pigs naturally and experimentally infected with Chlamydia (C...
  30. doi Chlamydia-like bacteria in respiratory samples of community-acquired pneumonia patients
    Susanne Haider
    Department of Microbial Ecology, University of Vienna, Althanstrasse, Vienna, Austria
    FEMS Microbiol Lett 281:198-202. 2008
    b>Chlamydia-like bacteria, obligate intracellular relatives of Chlamydia trachomatis and Chlamydophila pneumoniae, are widely distributed in nature...
  31. pmc High frequency of chlamydial co-infections in clinically healthy sheep flocks
    Hannah Lenzko
    Institut für bakterielle Infektionen und Zoonosen, Friedrich Loeffler Institut, Naumburger Strasse 96a, 07743 Jena, Germany
    BMC Vet Res 7:29. 2011
    ..Seven vaccinated flocks were reviewed separately...
  32. ncbi The chlamydial inclusion: escape from the endocytic pathway
    Kenneth A Fields
    Host Parasite Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana 59840, USA
    Annu Rev Cell Dev Biol 18:221-45. 2002
    ..Despite being sequestered within a membrane-bound vacuole, chlamydiae clearly communicate with and manipulate the host cell from within this privileged intracellular niche...
  33. pmc Novel molecular markers of Chlamydia pecorum genetic diversity in the koala (Phascolarctos cinereus)
    James Marsh
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    BMC Microbiol 11:77. 2011
    b>Chlamydia pecorum is an obligate intracellular bacterium and the causative agent of reproductive and ocular disease in several animal hosts including koalas, sheep, cattle and goats. C...
  34. doi Overcoming the barriers to chlamydia screening in general practice--a qualitative study
    Cliodna A M McNulty
    Health Protection Agency Primary Care Unit, Microbiology Department, Gloucestershire Royal Hospital, Great Western Road, Gloucester GL1 3NN, UK
    Fam Pract 27:291-302. 2010
    There is low uptake of chlamydia screening in general practices registered with the English National Chlamydia Screening Programme (NCSP). Aims...
  35. pmc Methodologies and cell lines used for antimicrobial susceptibility testing of Chlamydia spp
    R J Suchland
    Division of Allergy and Infectious Diseases, School of Medicine, University of Washington, Seattle, Washington, USA
    Antimicrob Agents Chemother 47:636-42. 2003
    In vitro susceptibility testing was performed on strains of Chlamydia trachomatis, Chlamydia pneumoniae, and Chlamydia psittaci under various conditions, including the cell line utilized, the time between infection and the addition of an ..
  36. ncbi Impact of latent infections with Chlamydophila species in young cattle
    Petra Reinhold
    Institute of Molecular Pathogenesis, Friedrich Loeffler Institute FLI, Naumburger Street 96 a, 07743 Jena, Germany
    Vet J 175:202-11. 2008
    ..In conclusion, naturally occurring infections with Chlamydophila species in calves were found to be associated with chronic effects on animal health at a subclinical level...
  37. pmc Tapping the nucleotide pool of the host: novel nucleotide carrier proteins of Protochlamydia amoebophila
    Ilka Haferkamp
    Pflanzenphysiologie, Technische Universitat Kaiserslautern, Erwin Schrödinger Str, D 67653 Kaiserslautern, Germany
    Mol Microbiol 60:1534-45. 2006
    ..amoebophila in this and previous studies uncovered that these metabolically impaired bacteria are intimately connected with their host cell's metabolism in a surprisingly complex manner...
  38. pmc Growth and development of tetracycline-resistant Chlamydia suis
    J Lenart
    Department of Microbiology, Oregon State University, Corvallis, Oregon 97331, USA
    Antimicrob Agents Chemother 45:2198-203. 2001
    ..the treatment of chlamydial infections in both humans and animals, and the emergence of TET-resistant (Tet(r)) Chlamydia is of significant clinical importance...
  39. doi The chlamydial OTU domain-containing protein ChlaOTU is an early type III secretion effector targeting ubiquitin and NDP52
    Ana Rita Furtado
    Institut Pasteur, Unite de Biologie des Interactions Cellulaires, Paris, France CNRS URA 2582, Paris, France
    Cell Microbiol 15:2064-79. 2013
    b>Chlamydia are obligate intracellular pathogens. Upon contact with the host, they use type III secretion to deliver proteins into the cell, thereby triggering actin-dependent entry and establishing the infection...
  40. pmc TLR2, but not TLR4, is required for effective host defence against Chlamydia respiratory tract infection in early life
    Emma L Beckett
    Centre for Asthma and Respiratory Disease, The University of Newcastle, and Hunter Medical Research Institute, Newcastle, New South Wales, Australia
    PLoS ONE 7:e39460. 2012
    b>Chlamydia pneumoniae commonly causes respiratory tract infections in children, and epidemiological investigations strongly link infection to the pathogenesis of asthma...
  41. pmc Fierce competition between Toxoplasma and Chlamydia for host cell structures in dually infected cells
    Julia D Romano
    Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    Eukaryot Cell 12:265-77. 2013
    The prokaryote Chlamydia trachomatis and the protozoan Toxoplasma gondii, two obligate intracellular pathogens of humans, have evolved a similar modus operandi to colonize their host cell and salvage nutrients from organelles...
  42. ncbi Chlamydia infection of epithelial cells expressing dynamin and Eps15 mutants: clathrin-independent entry into cells and dynamin-dependent productive growth
    H Boleti
    Unite de Biologie des Interactions Cellulaires, Institut Pasteur, URA CNRS 1960, rue du Dr Roux, France
    J Cell Sci 112:1487-96. 1999
    ..endocytosis was inhibited by overexpression of the dynK44A mutant of dynamin I (defective in GTPase activity), Chlamydia entry was not affected...
  43. pmc Uptake of biotin by Chlamydia Spp. through the use of a bacterial transporter (BioY) and a host-cell transporter (SMVT)
    Derek J Fisher
    Department of Microbiology, Southern Illinois University, Carbondale, United States of America
    PLoS ONE 7:e46052. 2012
    b>Chlamydia spp. are obligate intracellular Gram-negative bacterial pathogens that cause disease in humans and animals. Minor variations in metabolic capacity between species have been causally linked to host and tissue tropisms...
  44. pmc Translation inhibition of the developmental cycle protein HctA by the small RNA IhtA is conserved across Chlamydia
    Jeremiah Tattersall
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USA
    PLoS ONE 7:e47439. 2012
    The developmental cycle of the obligate intracellular pathogen Chlamydia trachomatis serovar L2 is controlled in part by the small non-coding RNA (sRNA), IhtA...
  45. pmc Plasmid-cured Chlamydia caviae activates TLR2-dependent signaling and retains virulence in the guinea pig model of genital tract infection
    Lauren C Frazer
    Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e30747. 2012
    ..These data indicate that either the plasmid is not involved in expression or regulation of virulence in C. caviae or that redundant effectors prevent these phenotypic changes from being observed in C. caviae plasmid-cured strains...
  46. pmc The Chlamydia effector chlamydial outer protein N (CopN) sequesters tubulin and prevents microtubule assembly
    Tara L Archuleta
    Division of Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 286:33992-8. 2011
    b>Chlamydia species are obligate intracellular pathogens that utilize a type three secretion system to manipulate host cell processes...
  47. ncbi Chlamydial interferon gamma immune evasion influences infection tropism
    Grant McClarty
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    Curr Opin Microbiol 10:47-51. 2007
    b>Chlamydia trachomatis is a human pathogen and Chlamydia muridarum is a mouse pathogen but paradoxically, they share near genomic synteny...
  48. ncbi Multiple co-infections (Mycoplasma, Chlamydia, human herpes virus-6) in blood of chronic fatigue syndrome patients: association with signs and symptoms
    G L Nicolson
    The Institute for Molecular Medicine, Huntington Beach, California 92649, USA
    APMIS 111:557-66. 2003
    ..polymerase chain reaction we also examined whether these same patients showed evidence of infections with Chlamydia pneumoniae (overall 7.5% positive) and/or active human herpes virus-6 (HHV-6, overall 30.5% positive)...
  49. pmc Chlamydia-infected cells continue to undergo mitosis and resist induction of apoptosis
    Whitney Greene
    Department of Microbiology and Immunology University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Infect Immun 72:451-60. 2004
    ..None of the serovars caused any biologically significant apoptosis in the infected host cells. Host cells in chlamydia-infected cultures can continue to undergo DNA synthesis and mitosis...
  50. ncbi What is the prevalence and economic impact of chlamydial infections in cattle? The need to validate and harmonise existing methods of detection
    M Livingstone
    Vet J 172:3-5. 2006
  51. ncbi A novel recombinant multisubunit vaccine against Chlamydia
    Francis O Eko
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 173:3375-82. 2004
    ..an efficacious vaccine is the most effective long-term measure to control the oculogenital infections caused by Chlamydia trachomatis in humans...
  52. doi Chlamydia vaccine candidates and tools for chlamydial antigen discovery
    Daniel D Rockey
    Associate Professor, College of Veterinary Medicine, Oregon State University, 211 Dryden Hall, Corvallis, OR 97331 4804, USA
    Expert Rev Vaccines 8:1365-77. 2009
    The failure of the inactivated Chlamydia-based vaccine trials in the 1960s has led researchers studying Chlamydia to take cautious and rational approaches to develop safe and effective chlamydial vaccines...
  53. pmc The Chlamydia psittaci genome: a comparative analysis of intracellular pathogens
    Anja Voigt
    Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    PLoS ONE 7:e35097. 2012
    ..To investigate genomic aspects of infection, virulence and host preference we have sequenced Chlamydia psittaci, the pathogenic agent of ornithosis.
  54. ncbi Chlamydial infection of immune cells: altered function and implications for disease
    Kenneth W Beagley
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia
    Crit Rev Immunol 29:275-305. 2009
    b>Chlamydia trachomatis is an obligate intracellular bacterial pathogen that infects the genital and ocular mucosa of humans, causing infections that can lead to pelvic inflammatory disease, infertility, and blinding trachoma. C...
  55. pmc The quantity of nitric oxide released by macrophages regulates Chlamydia-induced disease
    Jin Huang
    Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    Proc Natl Acad Sci U S A 99:3914-9. 2002
    Intracellular bacteria of the genus Chlamydia cause numerous typically chronic diseases, frequently with debilitating sequelae. Genetic determinants of disease susceptibility after infection with Chlamydia bacteria are unknown...
  56. ncbi Genome and proteome analysis of Chlamydia
    Brian B S Vandahl
    Department of Medical Microbiology and Immunology, Aarhus University, Denmark
    Proteomics 4:2831-42. 2004
    It has been difficult to study the molecular biology of the obligate intracellular bacterium Chlamydia due to lack of genetic transformation systems...
  57. doi Computer reminders for Chlamydia screening in general practice: a randomized controlled trial
    Jennifer Walker
    University of Melbourne, Victoria, Australia
    Sex Transm Dis 37:445-50. 2010
    b>Chlamydia notifications are increasing in Australia, and the use of a computer alert prompting general practitioners to test young women is a potential way to increase opportunistic chlamydia testing...
  58. pmc Primary cultures of female swine genital epithelial cells in vitro: a new approach for the study of hormonal modulation of Chlamydia infection
    Natalia V Guseva
    Department of Microbiology, J H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Infect Immun 71:4700-10. 2003
    ..sequelae found in humans, because of the near identity of a natural infectious chlamydial isolate from swine to Chlamydia trachomatis serovar D from humans, and because a pig's epithelial cell physiology and the mean length of its ..
  59. pmc Tetracycline resistance in Chlamydia suis mediated by genomic islands inserted into the chlamydial inv-like gene
    Jae Dugan
    Department of Biomedical Sciences, Oregon State University, 106 Dryden Hall, Corvallis, OR 97331 4804, USA
    Antimicrob Agents Chemother 48:3989-95. 2004
    Many strains of Chlamydia suis, a pathogen of pigs, express a stable tetracycline resistance phenotype. We demonstrate that this resistance pattern is associated with a resistance gene, tet(C), in the chlamydial chromosome...
  60. doi An experimentally induced Chlamydia suis infection in pigs results in severe lung function disorders and pulmonary inflammation
    Petra Reinhold
    Institute of Molecular Pathogenesis at the Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Naumburger Str 96a, 07743 Jena, Germany
    Vet Res 39:35. 2008
    ..Eight animals were exposed to Chlamydia suis (C. suis) and four non-infected animals served as controls...
  61. doi Detection of all Chlamydophila and Chlamydia spp. of veterinary interest using species-specific real-time PCR assays
    Alexandra Pantchev
    Chemisches und Veterinaruntersuchungsamt Stuttgart, Schaflandstr 3 3, 70736 Fellbach, Germany
    Comp Immunol Microbiol Infect Dis 33:473-84. 2010
    ..Detection in cattle of Cp. psittaci (11% of samples) and Chlamydia (C.) suis (9%), as well as Cp. psittaci in a goat sample was somewhat unexpected...
  62. pmc Identifying catalytic residues in CPAF, a Chlamydia-secreted protease
    Ding Chen
    Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Arch Biochem Biophys 485:16-23. 2009
    ..protease designated CPAF (Chlamydial Protease/proteasome-like Activity Factor) degrades host proteins, enabling Chlamydia to evade host defenses and replicate. The mechanistic details of CPAF action, however, remain obscure...
  63. ncbi Dendritic cells from Chlamydia-infected mice show altered Toll-like receptor expression and play a crucial role in inhibition of allergic responses to ovalbumin
    Xiaobing Han
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Eur J Immunol 34:981-9. 2004
    Our previous study has shown that Chlamydia lung infection can inhibit local eosinophilic inflammation induced by allergen sensitization and challenge, which is correlated with altered cytokine production...
  64. ncbi Chlamydia
    Robert Belland
    University of Tennessee, Memphis, 38163, USA
    Nat Rev Microbiol 2:530-1. 2004
  65. pmc Application of a Mycoplasma group-specific PCR for monitoring decontamination of Mycoplasma-infected Chlamydia sp. strains
    J M Ossewaarde
    Research Laboratory for Infectious Diseases, National Institute of Public Health and Environmental Hygiene, Bilthoven, The Netherlands
    Appl Environ Microbiol 62:328-31. 1996
    ..and demonstrate its use in monitoring decontamination procedures with Mycoplasma-contaminated suspensions of Chlamydia spp...
  66. doi Chlamydiaceae in cattle: commensals, trigger organisms, or pathogens?
    Petra Reinhold
    Institute of Molecular Pathogenesis at The Friedrich Loeffler Institut, Naumburger Str 96a, 07743 Jena, Germany
    Vet J 189:257-67. 2011
    ..pecorum, C. abortus, C. psittaci and Chlamydia suis, is ubiquitous with mixed infections occurring frequently...
  67. pmc Genome sequence of the obligate intracellular animal pathogen Chlamydia pecorum E58
    Sergio Mojica
    Department of Microbial Pathogenesis, University of Maryland Dental School, 650 W Baltimore Street, Baltimore, Maryland 21201, USA
    J Bacteriol 193:3690. 2011
    b>Chlamydia pecorum is an obligate intracellular bacterial pathogen that causes diverse disease in a wide variety of economically important mammals. We report the finished complete genome sequence of C...
  68. ncbi Bacterial secretion systems with an emphasis on the chlamydial Type III secretion system
    Delphine Sylvie Anne Beeckman
    Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, Ghent, Belgium
    Curr Issues Mol Biol 12:17-41. 2010
    ..We therefore propose a model of the chlamydial Type III secretion system and summarize current knowledge on the role of Type III secretion in the different stages of the chlamydial developmental cycle...
  69. pmc Production of a proteolytically active protein, chlamydial protease/proteasome-like activity factor, by five different Chlamydia species
    Feng Dong
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Infect Immun 73:1868-72. 2005
    ..factor (CPAF), for degrading host transcription factors in cells infected with the human chlamydial species Chlamydia trachomatis or Chlamydia pneumoniae...
  70. ncbi Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis
    Shirley M L Tse
    Department of Pediatrics, Division of Rheumatology, The Hospital for Sick Children, University of Toronto, Toronto M5G 1X8, Canada
    J Biol Chem 280:25210-5. 2005
    ..b>Chlamydia utilizes both strategies, but the underlying molecular mechanisms are incompletely understood...
  71. ncbi Illuminating the evolutionary history of chlamydiae
    Matthias Horn
    Department of Microbial Ecology, Institute of Ecology and Conservation Biology, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria
    Science 304:728-30. 2004
    Chlamydiae are the major cause of preventable blindness and sexually transmitted disease. Genome analysis of a chlamydia-related symbiont of free-living amoebae revealed that it is twice as large as any of the pathogenic chlamydiae and ..
  72. pmc Is there a relation between Chlamydia infection and primary biliary cirrhosis?
    Patrick S C Leung
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA 95616, USA
    Clin Dev Immunol 10:227-33. 2003
    ..However, a recent report suggests that there is a specific association of Chlamydia pneumoniae in patients with PBC and that C...
  73. ncbi CADD, a Chlamydia protein that interacts with death receptors
    Frank Stenner-Liewen
    Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 277:9633-6. 2002
    ..The protein is encoded in the genome of Chlamydia trachomatis and has homologues in other Chlamydia species...
  74. ncbi Direct identification of chlamydiae from clinical samples using a DNA microarray assay: a validation study
    Nicole Borel
    Institute of Veterinary Pathology, University of Zurich, Switzerland
    Mol Cell Probes 22:55-64. 2008
    ..were examined by the ArrayTube (AT) DNA microarray assay to detect chlamydial DNA and identify the species of Chlamydia and Chlamydophila involved...
  75. pmc Structures of and allelic diversity and relationships among the major outer membrane protein (ompA) genes of the four chlamydial species
    B Kaltenboeck
    Department of Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803
    J Bacteriol 175:487-502. 1993
    ..One cluster included all Chlamydia trachomatis ompA alleles (trachoma group)...
  76. pmc "...they should be offering it": a qualitative study to investigate young peoples' attitudes towards chlamydia screening in GP surgeries
    Angela H Hogan
    Health Protection Agency, Primary Care Unit, Gloucester Royal Hospital, Gloucester, UK
    BMC Public Health 10:616. 2010
    Despite the known health and healthcare costs of untreated chlamydia infection and the efforts of the National Chlamydia Screening Programme (NCSP) to control chlamydia through early detection and treatment of asymptomatic infection, the ..
  77. pmc The conserved Tarp actin binding domain is important for chlamydial invasion
    Travis J Jewett
    Host Parasite Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS Pathog 6:e1000997. 2010
    ..Our findings indicate that Tarp mediated actin binding and nucleation is a conserved feature among diverse chlamydial species and this function plays a critical role in bacterial invasion of host cells...
  78. pmc Incentive payments to general practitioners aimed at increasing opportunistic testing of young women for chlamydia: a pilot cluster randomised controlled trial
    Jade E Bilardi
    Sexual Health Unit, Melbourne School of Population Health, The University of Melbourne, Carlton, Victoria 3053, Australia
    BMC Public Health 10:70. 2010
    ..The aim of this pilot study was to determine if offering general practitioners (GP) a small incentive payment per test would increase chlamydia testing in women aged 16 to 24 years, attending general practice.
  79. doi Chlamydia effector proteins and new insights into chlamydial cellular microbiology
    Raphael H Valdivia
    Department of Molecular Genetics and Microbiology and Center for Microbial Pathogenesis, Duke University Medical Center, Durham, NC 27710, USA
    Curr Opin Microbiol 11:53-9. 2008
    b>Chlamydia and Chlamydophila sp. are highly related obligate intracellular bacterial pathogens that cause sexually transmitted diseases, ocular infections and atypical pneumonias...
  80. ncbi Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana: a recently discovered enzyme in the biosynthesis of L-lysine by plants and Chlamydia
    Nobuhiko Watanabe
    Group in Protein Structure and Function, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    J Mol Biol 371:685-702. 2007
    ..In addition, LL-DAP-AT was recently found in Chlamydia sp., suggesting that inhibitors of this enzyme may also be effective against such organisms...
  81. doi Structural insights into parallel strategies for germline antibody recognition of lipopolysaccharide from Chlamydia
    Dylan W Evans
    Department of Biochemistry and Microbiology, University of Victoria, PO Box 3055 STN CSC, Victoria, BC, Canada V8P 3P6
    Glycobiology 21:1049-59. 2011
    ....
  82. ncbi Internalization of Chlamydia by dendritic cells and stimulation of Chlamydia-specific T cells
    D M Ojcius
    Unite de Biologie des Interactions Cellulaires, CNRS 1960, Institut Pasteur, Paris, France
    J Immunol 160:1297-303. 1998
    b>Chlamydia species are the causative agents of trachoma, various forms of pneumonia, and the most common sexually transmitted diseases...
  83. doi Chlamydia partner services for females in California family planning clinics
    Ying Ying Yu
    California Department of Public Health, Center for Infectious Diseases, Division of Communicable Disease Control, Sexually Transmitted Disease Control Branch, Richmond, CA 94804, USA
    Sex Transm Dis 38:913-8. 2011
    Prompt treatment of exposed partners is critical for preventing further transmission of chlamydia, reinfection, and sequelae among females...
  84. ncbi Chlamydia vaccines: strategies and status
    Joseph U Igietseme
    Microbiology and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, Georgia 30310, USA
    BioDrugs 16:19-35. 2002
    ..Tackling these challenges is further compounded by the biological complexity of chlamydia, the existence of multiple serovariants, the capacity to induce both protective and deleterious immune effectors,..
  85. doi Population-based prevalence of hepatitis B and C virus, HIV, syphilis, gonorrhoea and chlamydia in male injection drug users in Lagos, Nigeria
    W Tun
    Population Council, Washington, DC, USA
    Int J STD AIDS 24:619-25. 2013
    ..tested for hepatitis B surface antigen (HBV), hepatitis C antibody (HCV), HIV and syphilis, as well as genital chlamydia and gonorrhoea infections...
  86. ncbi Type III secretion à la Chlamydia
    Jan Peters
    Department of Biomedical Sciences, University of Maryland, Baltimore, MD 21201, USA
    Trends Microbiol 15:241-51. 2007
    ..A general mechanism is emerging whereby both early- and mid-cycle T3S-mediated activities and late T3S inactivation upon detachment of chlamydiae from the inclusion membrane are crucial for chlamydial intracellular development...
  87. doi Chlamydia, cyanobiont, or host: who was on top in the ménage à trois?
    Fabio Facchinelli
    Institute for Plant Biochemistry, Cluster of Excellence on Plant Sciences CEPLAS, Heinrich Heine University, Universitatsstrasse 1, D 40225 Dusseldorf, Germany
    Trends Plant Sci 18:673-9. 2013
    ..b>Chlamydia-like pathogens are the second major source of foreign genes in Archaeplastida, suggesting that these obligate ..
  88. pmc Multi-genome identification and characterization of chlamydiae-specific type III secretion substrates: the Inc proteins
    Pierre Dehoux
    Institut Pasteur, Unite de Biologie des Interactions Cellulaires, Paris, France
    BMC Genomics 12:109. 2011
    ..In this paper we sought to identify and analyze, using bioinformatics tools, all putative Inc proteins in published chlamydial genomes, including an environmental species...
  89. pmc The Waddlia genome: a window into chlamydial biology
    Claire Bertelli
    Center for Research on Intracellular Bacteria, Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
    PLoS ONE 5:e10890. 2010
    ..Due to the lack of genetic tools to manipulate chlamydia, genomic analysis is proving to be the most incisive tool in stimulating investigations into the biology of ..
  90. pmc Characterization of the activity and expression of arginine decarboxylase in human and animal Chlamydia pathogens
    Kimberly A Bliven
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    FEMS Microbiol Lett 337:140-6. 2012
    b>Chlamydia pneumoniae encodes a functional arginine decarboxylase (ArgDC), AaxB, that activates upon self-cleavage and converts l-arginine to agmatine...
  91. doi Effector protein modulation of host cells: examples in the Chlamydia spp. arsenal
    Helen J Betts
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Curr Opin Microbiol 12:81-7. 2009
    As obligate intracellular parasites, Chlamydia spp. must create and maintain a specialized intracellular niche while simultaneously contending with potent host defenses...
  92. doi Experimental enteric infection of gnotobiotic piglets with Chlamydia suis strain S45
    Franco Guscetti
    Institute of Veterinary Pathology, University of Zurich, Vetsuisse Faculty, Winterthurerstr 268, CH 8057 Zurich, Switzerland
    Vet Microbiol 135:157-68. 2009
    Enteric chlamydial infections of pigs with Chlamydia (C.) suis are frequent and often subclinical. The enteric pathogenicity of C. suis strain S45 was investigated in gnotobiotic piglets...
  93. ncbi Cell death and inflammation during infection with the obligate intracellular pathogen, Chlamydia
    Jean Luc Perfettini
    Laboratoire Apoptose, Cancer et Immunité, CNRS UMR 1599, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Biochimie 85:763-9. 2003
    Infections by Chlamydia are followed by a strong inflammatory response, which is necessary to eliminate the infection, but at the same time is responsible for the pathology of infection...
  94. doi Is jail screening associated with a decrease in Chlamydia positivity among females seeking health services at community clinics?-San francisco, 1997-2004
    Pennan M Barry
    Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Sex Transm Dis 36:S22-8. 2009
    Young adults entering jail are at increased risk for sexually transmitted diseases (STD) such as chlamydia, are released quickly, and are unlikely to be tested for STDs elsewhere...
  95. ncbi Serum levels of soluble HLA and IL-2R molecules in patients with urogenital chlamydia infection
    Victor V Novikov
    N I Lobachevsky State University of Nizhny Novgorod, Russia
    Adv Exp Med Biol 601:285-9. 2007
    ..We concluded that Th1 immune responses might dominate during genital chlamydial infection contrary to the state of nonspecific inflammation of urogenital tract...
  96. pmc An automated image-based method for rapid analysis of Chlamydia infection as a tool for screening antichlamydial agents
    Ichie Osaka
    Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA
    Antimicrob Agents Chemother 56:4184-8. 2012
    ..immunofluorescence assay is the preferred approach for accurate quantification of the intracellular growth of Chlamydia. In this study, an immunofluorescence image-based method (termed image-based automated chlamydial identification ..
  97. doi Raman microspectroscopy reveals long-term extracellular activity of Chlamydiae
    Susanne Haider
    Department of Microbial Ecology, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria
    Mol Microbiol 77:687-700. 2010
    ..and protein synthesis after extended extracellular incubation could also be demonstrated for the human pathogen Chlamydia trachomatis, which synthesizes stress-related proteins under these conditions as shown by 2-D gel ..
  98. doi A multi-subunit chlamydial vaccine induces antibody and cell-mediated immunity in immunized koalas (Phascolarctos cinereus): comparison of three different adjuvants
    Alison J Carey
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia
    Am J Reprod Immunol 63:161-72. 2010
    Chlamydial infections represent a major threat to the survival of the koala. Infections caused by Chlamydia pecorum cause blindness, infertility, pneumonia and urinary tract infections and represent a threat to the survival of the ..
  99. doi Isolation of a new chlamydial agent from infected domestic poultry coincided with cases of atypical pneumonia among slaughterhouse workers in France
    Karine Laroucau
    Bacterial Zoonoses Unit, French Food Safety Agency, 94706 Maisons Alfort, France
    Infect Genet Evol 9:1240-7. 2009
    ..These data suggest that each farm had been infected with a different strain of this new chlamydial agent, the zoonotic potential and the exact taxonomic status of which have yet to be defined...
  100. ncbi Chlamydial symbionts in the enigmatic Xenoturbella (Deuterostomia)
    Olle Israelsson
    Museum of Evolution, Uppsala University, Norbyvägen 16, S 752 36 Uppsala, Sweden
    J Invertebr Pathol 96:213-20. 2007
    ....
  101. doi Apoptosis resistance in Chlamydia-infected cells: a fate worse than death?
    Manu Sharma
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
    FEMS Immunol Med Microbiol 55:154-61. 2009
    b>Chlamydia has long been studied as an intracellular pathogen causing widespread diseases...

Research Grants76

  1. Integrated Microfluidic Platform for Point-of-Care Serodiagnostics
    Xiaowu Liang; Fiscal Year: 2013
    ..antigens for non-biodefense targets including: Bartonella henselae, Borrelia burgdorferi, Hepatitis B Virus, Chlamydia, Plasmodium falciparum, Human papillomavirus, and Herpes simplex virus...
  2. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
    ..inflammatory response in bacterial infection at a mucosal site, mice will be infected in the genital tract with Chlamydia muridarum, a natural parasite of mice and a strict mucosal pathogen, infecting only the superficial epithelial ..
  3. The role of novel, uncultivable bacteria in incident PID
    CATHERINE L contact HAGGERTY; Fiscal Year: 2011
    ..Although Chlamydia trachomatis and Neisseria gonorrhoeae are commonly associated with PID, the etiology of up to 70% of cases is ..
  4. A Rapid Point-of-care Diagnostic for Neisseria gonorrhoeae STDs
    Richard F Selden; Fiscal Year: 2012
    ..the target genome that would effectively render the pathogens invisible (as was recently seen a major European Chlamydia trachomatis strain), incapable of strain typing (making reliable epidemiology studies and contact tracing ..
  5. A Rapid Point-of-care Diagnostic for C.trachomitis STDs
    RICHARD F contact SELDEN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Improved diagnoses of Chlamydia trachomatis infections represent a critical unmet medical need. C...
  6. Enzymology of Chlamydia Pathogenesis
    Dewey G McCafferty; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The obligate intracellular bacterium Chlamydia trachomatis is the most common sexually-transmitted pathogen in the developed world, >100 million persons are infected worldwide annually. C...
  7. New Peptides for the Treatment of Multiple Sclerosis
    Christine Beeton; Fiscal Year: 2013
    ..and do not compromise the protective immune response to acute infection with viral (influenza) or bacterial (chlamydia) pathogens, they suffer from several limitations: (i) they are sensitive to changes in pH and temperature;(ii) ..
  8. A Rapid Point-of-care Diagnostic for C. trachomatis STDs
    Richard F Selden; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Improved diagnosis of Chlamydia trachomatis (Ct) infections represents a critical unmet medical need...
  9. Novel anti-toxin compounds against Yersinia infections
    Maurizio Pellecchia; Fiscal Year: 2010
    ..supporting efforts on understanding how Yersinia pestis, Salmonella enterica, Francisella tularensis, Chlamydia psiticai, and Strep. Pneumonia, for example, modulate innate immunity associated with these infections...
  10. Multilevel Targeted Therapeutics Using Surface Functionalized Nanoparticles encap
    JILL STEINBACH; Fiscal Year: 2012
    ..HSV-2 infection increases the likelihood of human immunodeficiency (HIV) coinfection 6-fold and increases HIV, Chlamydia, and syphilis prevalence in third-world countries...
  11. The influence of negative regulators of inflammation on C. trachomatis infections
    DAVID MARCELO OJCIUS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Chlamydia trachomatis (CT) is the leading bacterial cause of sexually-transmitted diseases (STD) in humans worldwide. Inflammation is required for elimination of chlamydial infection...
  12. Characterization of the NOD2 NBD domain and role in chronic inflammation
    Jae W Dugan; Fiscal Year: 2013
    ..expertise in molecular bacteriology during his thesis work investigating mechanisms of antibiotic resistance in Chlamydia. His current research interests involve understanding how the innate immune system contributes to human disease...
  13. MOLECULAR GENETIC ANALYSIS OF CHLAMYDIA PATHOGENICITY
    Anthony T Maurelli; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Bacteria of the genus Chlamydia are significant pathogens of animals and man. The diseases caused by Chlamydia spp...
  14. Development of an HIV Risk Reduction Intervention Protocol for Adolescent Africn-
    GWENDOLYN D CHILDS; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Alabama STI surveillance reports reveal rates of chlamydia, syphilis, and gonorrhea among African American (AA) girl increase more than 1000% between age groups 10 to 14 and 15 to 19, suggesting ..
  15. C. trachomatis-mediated signaling pathways required for Type I IFN responses
    JEFFREY RYAN BARKER; Fiscal Year: 2013
    ..b>Chlamydia trachomatis induces a potent Type I IFN response in many different cell types that is dependent on multiple ..
  16. Southern Community Cohort Study
    Wei Zheng; Fiscal Year: 2013
    ..many for the first time among African Americans, including the roles of obesity, vitamin D, specific infections (Chlamydia pneumoniae, Trichomonas vaginalis, Helicobacter pylori, and xenotropic murine leukemia virus-related virus), ..
  17. Development of a Chlamydia T Cell Vaccine Based on Dendritic Cell Immunoprotemics
    Leonard J Foster; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Chlamydia is one of the most widespread bacterial sexually transmitted diseases in the world causing an estimated 92 million infections per year with over 2.8 million infections in America alone...
  18. Validating metabolic pathways in the intracellular pathogen Chlamydia trachomatis
    DEREK JAMES FISHER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Chlamydia trachomatis is the leading cause of preventable blindness (~8 million visually impaired people worldwide) and bacteria-associated sexually transmitted diseases (STD) with over 900,000 ..
  19. Functional Characterization of CXCL14, CXCL17, and CCL28; three mucosal chemokine
    Albert Zlotnik; Fiscal Year: 2010
    ..We will test several microorganisms, including gram (+), gram (-), Candida albicans and Chlamydia trachomatis...
  20. Novel Bacterial Pathogens in Pelvic Inflammatory Disease
    Catherine L Haggerty; Fiscal Year: 2012
    ..Although Neisseria gonorrhoeae and/or Chlamydia trachomatis are recovered from approximately a third to a half of women with PID, in the other women the ..
  21. MOLECULAR GENETIC ANALYSIS OF CHLAMYDIA PATHOGENICITY
    Anthony T Maurelli; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bacteria of the genus Chlamydia are significant pathogens of animals and man. The diseases caused by Chlamydia spp...
  22. HAART optimism, drug use and risky sexual behavior among MSM in British Columbia.
    Robert Stephen Hogg; Fiscal Year: 2013
    ..gonnorhea and Chlamydia trachomatis and to provide consent to allow researchers access to health services databases in the province...
  23. HIV Prevention Intervention for Young Transgender Women
    MATTHEW JAMES MIMIAGA; Fiscal Year: 2013
    ..All three arms will receive HIV and STI (Chlamydia and gonorrhea) testing and pre-posttest risk reduction counseling (i.e., SOC)...
  24. The interaction of Chlamydia with the host cytoskeleton
    Scott S Grieshaber; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The obligate intracellular bacterium Chlamydia trachomatis is the world's leading cause of preventable blindness and the most common sexually transmitted bacterial pathogen of humans...
  25. Recombination and Genetics in Chlamydia spp.
    Daniel D Rockey; Fiscal Year: 2010
    ..Infections by Chlamydia trachomatis and C...
  26. Rapid and Cost-Effective Diagnostic System for Sexually Transmitted Infections
    John E Mueller; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): According to the CDC, chlamydia and gonorrhea, caused by Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG), respectively, are the first and second most frequently reported STIs in the US and ..
  27. Factors Mediating Host Resistance to Chlamydia trachomatis
    Michael N Starnbach; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Infection with Chlamydia trachomatis is responsible for significant morbidity throughout the world. Chronic genital infections with C...
  28. CHARACTERIZATION OF A NOVEL HOST PATHWAY THAT REGULATES CHLAMYDIAL DEVELOPMENT
    Robert V Schoborg; Fiscal Year: 2013
    ..9 billion dollars in the US in 2000. Genital Chlamydia trachomatis (2,800,000 new cases/year) and Herpes Simplex Virus type 2 (HSV-2;200- 500,000 new cases/year + <..
  29. T-bet regulates CD4 memory to bacterial infection with C. trachomatis
    David Gondek; Fiscal Year: 2010
    b>Chlamydia trachomatis is the most prevalent sexually transmitted bacterial infection in the US and the primary cause of preventable blindness worldwide...
  30. Cervical Maturity, Mucosal Immunity, and Chlamydia trachomatis infection
    Loris Y Hwang; Fiscal Year: 2012
    ..goals: 1) to conduct clinical translational research on cervical epithelial maturity, mucosal immunity, and Chlamydia trachomatis infection in adolescents;2) to gain knowledge of basic and mucosal immunology;3) to gain practical ..
  31. Computerized Counseling to Promote Positive Prevention and HIV Health in Kenya
    Ann Elizabeth Kurth; Fiscal Year: 2012
    ..risk will be measured by self-reported unprotected sex with HIV- negative/unknown partner, and trends in Chlamydia trachomatis, Neisseria gonorrhoeae, and T. vaginalis...
  32. In vivo observations of transcription at single-nucleotide resolution
    MATTHEW HERBERT LARSON; Fiscal Year: 2013
    ..pylori) and Chlamydia trachomatis (C...
  33. Sexual Health among Low-Income Female CSWs in China
    JENNIFER ZHIHUAN HUANG BOUEY; Fiscal Year: 2011
    ..The specific aims are to: (1) describe and compare the prevalence of unprotected sexual practices and STIs (Chlamydia, gonorrhea, syphilis, HSV-2, and HBV) between migrant and non-migrant street walkers;(2) describe and compare ..
  34. Immunodominant Stress Proteins of Porphyromonas gingivalis
    Dennis E Lopatin; Fiscal Year: 2010
    ..protective response to stress proteins may be involved in control of diseases like IBD, Legionella, Yersinia, Chlamydia and H. pylori infections and arteriosclerosis...
  35. Effects of a chlamydial ATP-consuming enzyme on the inflammasome
    MARIA LUISA AVILA; Fiscal Year: 2010
    b>Chlamydia trachomatis is the leading bacterial cause of sexually transmitted diseases in humans worldwide...
  36. Drug Abuse, Incarceration &Health Disparities in HIV/AIDS: A Longitudinal Study
    Linda A Teplin; Fiscal Year: 2013
    ..STI status, arrests, incarceration history, and services received);(4) test the entire sample for HIV infection, chlamydia, and gonorrhea;and (5) administer a new module on incarceration, release, and re-entry...
  37. Mechanism(s) of CD8 T cell-mediated Chlamydia-induced reproductive pathology
    ASHLESH KRISHNA MURTHY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Sexually transmitted diseases caused by Chlamydia trachomatis, an intracellular bacterial pathogen, affect approximately 90 million people worldwide...
  38. Randomized Trial of IFCBT-HIVPI to Prevent HIV Among Non-Injection Drug Users
    William W Latimer; Fiscal Year: 2013
    ..main effects on primary (HIV sexual risk behaviors and HIV drug taking risk behaviors) and secondary (HIV, Chlamydia, gonorrhea, and trichomoniasis incidences and legal involvement, academic achievement, and employment) outcome ..
  39. T-cell mediated immunity in chlamydia genital infection
    Kathleen A Kelly; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Chlamydia trachomatis, an obligate intracellular bacterium, causes the most cases of bacterial sexually transmitted infections (STIs)...
  40. Characterization of CCL28,CXCL14, and CXCL17, three mucosal chemokines
    Albert Zlotnik; Fiscal Year: 2013
    ..We will also infect these mice with two bacterial pathogens (Chlamydia and Salmonella) to investigate whether these chemokines play a role in immunity against these pathogens...
  41. Duet cervical barrier device for maximizing protective efficacy of microbicides
    Richard Cone; Fiscal Year: 2009
    ..permission via ReProtect's BufferGel IND to pursue clinical trials of BufferGel-Duet for preventing STIs (chlamydia, gonorrhea, trichomoniasis, and HIV), BV, and for contraception...
  42. The Immune Pathogenesis of Prenatal Listeria monocytogenes Infection
    Sing Sing Way; Fiscal Year: 2013
    ..A number of human pathogens that includes Listeria, Plasmodium, E. coli, Group B Streptococcus, Salmonella, Chlamydia and cytomegalovirus each have a defined predisposition for prenatal infection that often results in spontaneous ..
  43. A Point of Care, Nucleic Acid Test for Chlamydia to Ensure Prompt Treatment of He
    LAURA T MAZZOLA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This proposal supports the translation of a new point-of-care STD (chlamydia) diagnostic test into a community clinic testing program, toward the goal of increasing early identification of chlamydia ..
  44. Preventing HIV/AIDS Among Teens in Juvenile Justice
    Geri R Donenberg; Fiscal Year: 2013
    ..will occur at baseline, 6-, and 12-months post-treatment, and we will screen youth for three common STIs (Chlamydia, Gonorrhea, Trichamonas) at baseline and 12-month follow-up...
  45. Evaluation of CPAF Mediated Anti-Chlamydial Immunity in the Guinea Pig
    BERNARD PRAGASH ARULANANDAM; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Chlamydia trachomatis is the leading cause of bacterial sexually transmitted disease worldwide...
  46. Peptide Deformylase Inhibitor LBM415 for Sexually Transmitted Infections
    Huizhou Fan; Fiscal Year: 2011
    ..b>Chlamydia trachomatis and Neisseria gonorrhoeae are the most common sexually transmitted pathogens...
  47. Development of an in vivo model of chlamydial persistence.
    Robert V Schoborg; Fiscal Year: 2010
    b>Chlamydia trachomatis, the most common bacterial sexually transmitted disease (STD) agent worldwide, often establishes asymptomatic genital infections which result in serious reproductive complications...
  48. Synthetic Models and Spectroscopy of Metal-Oxo Proteins
    Lawrence Que; Fiscal Year: 2013
    ..discovered ribonucleotide reductase (RNR) with a FeMn active site (instead of a diiron site) from the parasite Chlamydia trachomatis...
  49. Role of Innate Immunity in Pathogenesis of Chlamydia Pneumonia Infection
    Moshe Arditi; Fiscal Year: 2010
    b>Chlamydia pneumoniae is an important cause of community acquired pneumonia that also significantly contributes to allergic airway disease and exacerbation of asthma...
  50. Scanning Chlamydia proteome for vaccine antigens
    Luis M de la Maza; Fiscal Year: 2010
    Throughout the World Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen. In areas with poor sanitary conditions C. trachomatis causes trachoma the most common cause of preventable blindness in the World...
  51. Innate Immunity and Pathogen mediated Acceleration in Vascular Inflammation
    Shuang Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chlamydia pneumoniae (CP) is a common respiratory pathogen associated with atypical pneumonia, which has been associated as a trigger or promoter of several chronic inflammatory conditions, such as ..
  52. STI Risk among adolescent females: activity spaces and spatial mobility
    ELIZABETH ANN REED; Fiscal Year: 2013
    ..determine the role of social spaces (locations where social interactions occur) and spatial mobility on risk for chlamydia and gonorrhea among adolescent girls living near the US-Mexico border...
  53. Trapping membrane proteins with adjuvant-carrying amphipols for vaccine formulati
    Luis M de la Maza; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chlamydia trachomatis infections are widespread throughout the World...
  54. Nested case-control study of maternal herpes viruses in relation to gastroschisis
    Martha M Werler; Fiscal Year: 2013
    ..the epidemiologic profile of gastroschisis: Epstein-Barr virus, herpes simplex virus 2, cytomegalovirus, and Chlamydia trachomatis...
  55. MHC-Ib restricted T cell responses against Listeria monocytogenes
    SARAH E F D apos ORAZIO; Fiscal Year: 2010
    ..studies have the potential to lead to new therapeutic strategies to protect against infections with a variety of intracellular bacteria, including prevalent human pathogens such as Mycobacteria tuberculosis and Chlamydia trachomatis.
  56. Biodegradable Nanoparticles for Targeted Antibiotic Delivery
    Judith A Whittum-Hudson; Fiscal Year: 2012
    Human infections by the intracellular bacterial pathogens Chlamydia trachomatis and C pneumoniae present an enormous health care problem...
  57. Role of Chlamydia Species in Preterm Birth and Placental Dysfunction
    Robin R Ingalls; Fiscal Year: 2013
    ..b>Chlamydia species have long been known to be associated with abortion in ruminants. However, the role of C...
  58. 18F-Fallypride Micropet Imaging to Monitor Pancreatic Beta Cell Loss in Diabetes
    Adriana Garcia; Fiscal Year: 2010
    ..channels, treated CR-EAE in DA rats, and at therapeutic concentrations did not compromise the immune response to chlamydia trachomatis. These data have been submitted for publication...
  59. Evolving HIV/STI risk environments of FSWs on the Mexico/U.S. Border
    Kimberly C Brouwer; Fiscal Year: 2013
    ..All will be tested for HIV, syphilis, gonorrhea, and Chlamydia and treated as needed. Follow-up interviews and testing will occur at months 6, 12, and 18...
  60. 12th International Symposium on Human Chlamydial Infections
    Julius Schachter; Fiscal Year: 2010
    ..b>Chlamydia trachomatis infections are the most common bacterial cause of sexually transmitted diseases often resulting in ..
  61. UNC-South China STD Research Training Center
    JOSEPH DAVID TUCKER; Fiscal Year: 2013
    ..The Center will focus on classical STDs (syphilis, gonorrhea, chlamydia, HIV, human papillomavirus) as well as hepatitis B and hepatitis C...
  62. INDUCTION OF PROTECTIVE IMMUNITY AGAINST CHLAMYDIA
    Francis O Eko; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chlamydia trachomatis, composed of 15 odd serovars (A through K and L1 to L3) with serovars D through K and the lymphogranuloma venereum strains L1 - L3 causing sexually transmitted diseases (STDs), ..
  63. Can Chlamydial Infection Increase Host Mutation Frequency?
    ROBERT SCHOBORG; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The bacterium Chlamydia trachomatis is a common sexually transmitted disease agent, with 4,000,000 new cases/year in the US. C...
  64. Combination Antibotics as a Treatment for Chlamydia-Induced Reactive Arthritis
    John Carter; Fiscal Year: 2007
    ..b>Chlamydia trachomatis (Ct) is a known trigger for ReA...
  65. RECOMBINANT POLYTYPIC CHLAMYDIA VACCINE
    LUIS DE LA MAZA; Fiscal Year: 1991
    The objective of this proposal is to develop a recombinant polytypic vaccine for Chlamydia trachomatis infections. C...
  66. HIV AND STIS IN YOUNG ADULTS: A NETWORK APPROACH
    W Morris; Fiscal Year: 2003
    ..Specimens will be tested for four STIs in Survey 2000: Chlamydia trachomatis (Ct), Neisseria gonorrhea (GC), Trichomonas vaginalis (Tv), and human immunodeficiency virus (HIV)...
  67. MOLECULAR GENETIC ANALYSIS OF CHLAMYDIA PATHOGENICITY
    ANTHONY MAURELLI; Fiscal Year: 2004
    Bacteria of the genus Chlamydia are significant pathogens of animals and man. The diseases caused by Chlamydia spp...
  68. Mechanism of Chlamydia-induced centrosome amplification
    Ming Tan; Fiscal Year: 2010
    b>Chlamydia infections are the most commonly reported infectious disease in the U.S...
  69. Chaperone Mining of the Chlamydia Type Three Secretion System
    ELLENA MARIE PETERSON; Fiscal Year: 2010
    b>Chlamydia trachomatis is a leading cause of sexually transmitted diseases...
  70. The Elimination of Health Disparities through Translation Research
    Carol E Kaufman; Fiscal Year: 2010
    ..In fact, 11 of the 12 service areas of the Indian Health Service (IHS) show rates of Chlamydia trachomatis (Chlamydia) higher than the US average, with 3 of these service areas at levels 5-6 times higher...
  71. Rapid Point-of-Care Diagnostic Test for Chlamydia and Gonorrhea
    DAVID DOLINGER; Fiscal Year: 2007
    ..to develop a rapid, point-of-care (POC), nucleic acid amplification based diagnostic test for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae using our innovative "Lab-in-a-tube" (LiatTM) technology...
  72. Targeted Genetic Modifications of Chlamydia Trachomatis
    ROBERT DE MARS; Fiscal Year: 2004
    b>Chlamydia trachomatis is the most common cause of bacterial sexually transmitted disease and of preventable blindness in humans...
  73. IMMUNOPATHOLOGY OF CHLAMYDIA--INDUCED REACTIVE ARTHRITIS
    Roger Rank; Fiscal Year: 1991
    ..with Yersinia enterocolitica, Salmonella, Shigella, and Campylobacter and from genital tract infections with Chlamydia trachomatis...
  74. INFECTION AND CARDIOVASCULAR DISEASE
    Michael Davidson; Fiscal Year: 2001
    Recent studies have associated evidence of Chlamydia pneumoniae infection with coronary and carotid atherosclerosis and evidence of increased infection with cytomegalovirus (CMV) in patients developing restenosis or with atherosclerosis...
  75. Cellular Immunity to Chlamydua at the Epithelial Interface
    RAYMOND MORRIS JOHNSON; Fiscal Year: 2010
    b>Chlamydia trachomatis has a marked tissue tropism, replicating almost exclusively in epithelial cells lining the reproductive tract. The Chlamydia muridarum mouse model for human C...
  76. TLR2 ligands of chlamydiae
    CATHERINE M O apos CONNELL; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Chlamydia trachomatis infections are the leading cause of involuntary infertility and ectopic pregnancy in women...