campylobacter jejuni

Summary

Summary: A species of bacteria that resemble small tightly coiled spirals. Its organisms are known to cause abortion in sheep and fever and enteritis in man and may be associated with enteric diseases of calves, lambs, and other animals.

Top Publications

  1. pmc eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Bacteriol 186:1518-30. 2004
  2. ncbi Ciprofloxacin resistance in Campylobacter jejuni evolves rapidly in chickens treated with fluoroquinolones
    Patrick F McDermott
    Division of Animal and Food Microbiology, Center for Veterinary Medicine, US Food and Drug Administration, Laurel, Maryland 20708, USA
    J Infect Dis 185:837-40. 2002
  3. ncbi Protein glycosylation in bacteria: sweeter than ever
    Harald Nothaft
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
    Nat Rev Microbiol 8:765-78. 2010
  4. pmc Evolutionary dynamics of complete Campylobacter pan-genomes and the bacterial species concept
    Tristan Lefebure
    Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, New York, USA
    Genome Biol Evol 2:646-55. 2010
  5. ncbi Risk factors for indigenous Campylobacter jejuni and Campylobacter coli infections in The Netherlands: a case-control study
    Y Doorduyn
    Epidemiology and Surveillance Unit, Netherlands Centre for Infectious Disease Control, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Epidemiol Infect 138:1391-404. 2010
  6. ncbi Active migration into the subcellular space precedes Campylobacter jejuni invasion of epithelial cells
    Lieke B van Alphen
    Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
    Cell Microbiol 10:53-66. 2008
  7. pmc L-fucose utilization provides Campylobacter jejuni with a competitive advantage
    Martin Stahl
    Department of Biochemistry, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada
    Proc Natl Acad Sci U S A 108:7194-9. 2011
  8. pmc MUC1 cell surface mucin is a critical element of the mucosal barrier to infection
    Julie L McAuley
    Mucosal Diseases Program, Mater Medical Research Institute and The University of Queensland, South Brisbane, Queensland, Australia
    J Clin Invest 117:2313-24. 2007
  9. pmc Phenotypic and genotypic evidence for L-fucose utilization by Campylobacter jejuni
    Wayne T Muraoka
    Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA 50011, USA
    J Bacteriol 193:1065-75. 2011
  10. ncbi Identification of essential genes in C. jejuni genome highlights hyper-variable plasticity regions
    Martin Stahl
    Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada
    Funct Integr Genomics 11:241-57. 2011

Detail Information

Publications348 found, 100 shown here

  1. pmc eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Bacteriol 186:1518-30. 2004
    ..pneumoniae and Staphylococcus aureus MLST databases, and the more complicated clonal complexes observed for Campylobacter jejuni and Neisseria meningitidis.
  2. ncbi Ciprofloxacin resistance in Campylobacter jejuni evolves rapidly in chickens treated with fluoroquinolones
    Patrick F McDermott
    Division of Animal and Food Microbiology, Center for Veterinary Medicine, US Food and Drug Administration, Laurel, Maryland 20708, USA
    J Infect Dis 185:837-40. 2002
    ..In separate experiments, the effects of sarafloxacin and enrofloxacin treatment of Campylobacter jejuni-infected chickens on the development of ciprofloxacin resistance were measured...
  3. ncbi Protein glycosylation in bacteria: sweeter than ever
    Harald Nothaft
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
    Nat Rev Microbiol 8:765-78. 2010
    ..Improving our understanding of the intricacies of bacterial protein glycosylation systems should lead to new opportunities to manipulate these pathways in order to engineer glycoproteins with potential value as novel vaccines...
  4. pmc Evolutionary dynamics of complete Campylobacter pan-genomes and the bacterial species concept
    Tristan Lefebure
    Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, New York, USA
    Genome Biol Evol 2:646-55. 2010
    ....
  5. ncbi Risk factors for indigenous Campylobacter jejuni and Campylobacter coli infections in The Netherlands: a case-control study
    Y Doorduyn
    Epidemiology and Surveillance Unit, Netherlands Centre for Infectious Disease Control, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Epidemiol Infect 138:1391-404. 2010
    A case-control study comprising 1315 Campylobacter jejuni cases, 121 Campylobacter coli cases and 3409 frequency-matched controls was conducted in The Netherlands in 2002-2003. Risk factors for both C. jejuni and C...
  6. ncbi Active migration into the subcellular space precedes Campylobacter jejuni invasion of epithelial cells
    Lieke B van Alphen
    Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
    Cell Microbiol 10:53-66. 2008
    The bacterial pathogen Campylobacter jejuni invades mucosal cells via largely undefined and rather inefficient (0.01-2 bacteria per cell) mechanisms. Here we report a novel, highly efficient C...
  7. pmc L-fucose utilization provides Campylobacter jejuni with a competitive advantage
    Martin Stahl
    Department of Biochemistry, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada
    Proc Natl Acad Sci U S A 108:7194-9. 2011
    b>Campylobacter jejuni is a prevalent gastrointestinal pathogen in humans and a common commensal of poultry. When colonizing its hosts, C...
  8. pmc MUC1 cell surface mucin is a critical element of the mucosal barrier to infection
    Julie L McAuley
    Mucosal Diseases Program, Mater Medical Research Institute and The University of Queensland, South Brisbane, Queensland, Australia
    J Clin Invest 117:2313-24. 2007
    ..expression of mucin 1 (Muc1) cell surface mucin followed infection of mice with the bacterial pathogen Campylobacter jejuni. In the first week following oral infection, C...
  9. pmc Phenotypic and genotypic evidence for L-fucose utilization by Campylobacter jejuni
    Wayne T Muraoka
    Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA 50011, USA
    J Bacteriol 193:1065-75. 2011
    b>Campylobacter jejuni remains among the leading causes of bacterial food-borne illness. The current understanding of Campylobacter physiology suggests that it is asaccharolytic and is unable to catabolize exogenous carbohydrates...
  10. ncbi Identification of essential genes in C. jejuni genome highlights hyper-variable plasticity regions
    Martin Stahl
    Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada
    Funct Integr Genomics 11:241-57. 2011
    A microarray transposon-based tracking approach was used to identify Campylobacter jejuni genes which are required for cell growth at 37°C, under a microaerophilic atmosphere and on a rich Mueller-Hinton medium...
  11. pmc Novel murine infection models provide deep insights into the "ménage à trois" of Campylobacter jejuni, microbiota and host innate immunity
    Stefan Bereswill
    Department of Microbiology and Hygiene, Charite University Medicine Berlin, Berlin, Germany
    PLoS ONE 6:e20953. 2011
    Although Campylobacter jejuni-infections have a high prevalence worldwide and represent a significant socioeconomic burden, it is still not well understood how C. jejuni causes intestinal inflammation. Detailed investigation of C...
  12. pmc Quantitative RNA-seq analysis of the Campylobacter jejuni transcriptome
    Roy R Chaudhuri
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Microbiology 157:2922-32. 2011
    b>Campylobacter jejuni is the most common bacterial cause of foodborne disease in the developed world...
  13. pmc Bile salts modulate expression of the CmeABC multidrug efflux pump in Campylobacter jejuni
    Jun Lin
    Department of Veterinary Microbiology and Preventive Medicine, 1116 Veterinary Medicine Complex, Iowa State University, Ames, IA 50011, USA
    J Bacteriol 187:7417-24. 2005
    CmeABC, a multidrug efflux pump, is involved in the resistance of Campylobacter jejuni to a broad spectrum of antimicrobial agents and is essential for Campylobacter colonization in animal intestine by mediating bile resistance...
  14. ncbi Motility and chemotaxis in Campylobacter and Helicobacter
    Paphavee Lertsethtakarn
    Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California 95064, USA
    Annu Rev Microbiol 65:389-410. 2011
    Flagellar motility of Campylobacter jejuni and Helicobacter pylori influences host colonization by promoting migration through viscous milieus such as gastrointestinal mucus. This review explores mechanisms C. jejuni and H...
  15. ncbi The effect of lemon, orange and bergamot essential oils and their components on the survival of Campylobacter jejuni, Escherichia coli O157, Listeria monocytogenes, Bacillus cereus and Staphylococcus aureus in vitro and in food systems
    K Fisher
    School of Health, The University of Northampton, Northampton, UK
    J Appl Microbiol 101:1232-40. 2006
    ..To investigate the effectiveness of oils and vapours of lemon (Citrus limon), sweet orange (Citrus sinensis) and bergamot (Citrus bergamia) and their components against a number of common foodborne pathogens...
  16. pmc Bacteriophage F336 recognizes the capsular phosphoramidate modification of Campylobacter jejuni NCTC11168
    Martine C Holst Sørensen
    Department of Veterinary Disease Biology, University of Copenhagen, Stigbøjlen 4, 1870 Frederiksberg, Denmark
    J Bacteriol 193:6742-9. 2011
    Bacteriophages infecting the food-borne human pathogen Campylobacter jejuni could potentially be exploited to reduce bacterial counts in poultry prior to slaughter...
  17. pmc The cooperative action of bacterial fibronectin-binding proteins and secreted proteins promote maximal Campylobacter jejuni invasion of host cells by stimulating membrane ruffling
    Tyson P Eucker
    School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7520, USA
    Cell Microbiol 14:226-38. 2012
    This study was performed to elucidate the host cell scaffolding and signalling molecules that Campylobacter jejuni utilizes to invade epithelial cells. We hypothesized that the C...
  18. pmc CmeABC functions as a multidrug efflux system in Campylobacter jejuni
    Jun Lin
    Food Animal Health Research Program, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, Ohio 44691, USA
    Antimicrob Agents Chemother 46:2124-31. 2002
    b>Campylobacter jejuni, a gram-negative organism causing gastroenteritis in humans, is increasingly resistant to antibiotics. However, little is known about the drug efflux mechanisms in this pathogen...
  19. ncbi Molecular mechanisms of campylobacter infection
    Jos P M van Putten
    Department of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, Utrecht, The Netherlands
    Curr Top Microbiol Immunol 337:197-229. 2009
    b>Campylobacter jejuni is the principal bacterial foodborne pathogen. A major challenge still is to identify the virulence strategies exploited by C. jejuni. Recent genomics, proteomics, and metabolomics approaches indicate that C...
  20. ncbi Antagonistic activity of Lactobacillus acidophilus ATCC 4356 on the growth and adhesion/invasion characteristics of human Campylobacter jejuni
    Raffaella Campana
    Department of Biomolecular Science, Division of Toxicology, Hygienic and Environmental Science, University of Urbino Carlo Bo, Via S Chiara 27, Urbino, Italy
    Curr Microbiol 64:371-8. 2012
    ..probiotic activity of Lactobacillus acidophilus ATCC 4356 against several human Campylobacter jejuni isolates...
  21. ncbi Oxidative stress in Campylobacter jejuni: responses, resistance and regulation
    John M Atack
    Centre for Chemical Biology, Department of Chemistry, Krebs Institute, The University of Sheffield, Sheffield, S3 7HF, UK
    Future Microbiol 4:677-90. 2009
    b>Campylobacter jejuni is a major food-borne human pathogen that paradoxically is an oxygen-sensitive microaerophile, yet must resist the oxidative stresses encountered both in the host and in the environment...
  22. ncbi Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae
    Claudia Lupp
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Cell Host Microbe 2:204. 2007
    ..rodentium, which closely mimics human diarrheal pathogens inducing host intestinal inflammation, and Campylobacter jejuni infection, as well as chemically and genetically induced models of intestinal inflammation, we demonstrate ..
  23. ncbi Role of the small Rho GTPases Rac1 and Cdc42 in host cell invasion of Campylobacter jejuni
    Malgorzata Krause-Gruszczynska
    Department of Medical Microbiology, Otto von Guericke University Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Cell Microbiol 9:2431-44. 2007
    Host cell invasion of the food-borne pathogen Campylobacter jejuni is one of the primary reasons of tissue damage in humans but molecular mechanisms are widely unclear. Here, we show that C...
  24. pmc Unique features of a highly pathogenic Campylobacter jejuni strain
    Dirk Hofreuter
    Section of Microbial Pathogenesis, School of Medicine, Yale University, New Haven, Connecticut 06536, USA
    Infect Immun 74:4694-707. 2006
    b>Campylobacter jejuni, a major human enteric pathogen, exhibits significant strain-to-strain differences which result in differences in pathogenic potential. C...
  25. pmc Re-annotation and re-analysis of the Campylobacter jejuni NCTC11168 genome sequence
    Ozan Gundogdu
    Pathogen Molecular Department, London School of Hygiene and Tropical Medicine, UK
    BMC Genomics 8:162. 2007
    b>Campylobacter jejuni is the leading bacterial cause of human gastroenteritis in the developed world. To improve our understanding of this important human pathogen, the C. jejuni NCTC11168 genome was sequenced and published in 2000...
  26. pmc The sialylated lipooligosaccharide outer core in Campylobacter jejuni is an important determinant for epithelial cell invasion
    Rogier Louwen
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Infect Immun 76:4431-8. 2008
    b>Campylobacter jejuni is a frequent cause of bacterial gastroenteritis worldwide. Lipooligosaccharide (LOS) has been identified as an important virulence factor that may play a role in microbial adhesion and invasion...
  27. pmc Campylobacter genotyping to determine the source of human infection
    Samuel K Sheppard
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    Clin Infect Dis 48:1072-8. 2009
    ....
  28. pmc Host association of Campylobacter genotypes transcends geographic variation
    Samuel K Sheppard
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
    Appl Environ Microbiol 76:5269-77. 2010
    ..the robustness of this approach to the provenance of the reference data sets used, a collection of 742 Campylobacter jejuni and 261 Campylobacter coli isolates obtained from United Kingdom-sourced chicken meat was established and ..
  29. pmc Definition of the bacterial N-glycosylation site consensus sequence
    Michael Kowarik
    Institute of Microbiology, Department of Biology, Swiss Federal Institute of Technology Zurich, ETH Honggerberg, Switzerland
    EMBO J 25:1957-66. 2006
    The Campylobacter jejuni pgl locus encodes an N-linked protein glycosylation machinery that can be functionally transferred into Escherichia coli. In this system, we analyzed the elements in the C...
  30. ncbi Metabolic diversity in Campylobacter jejuni enhances specific tissue colonization
    Dirk Hofreuter
    Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Cell Host Microbe 4:425-33. 2008
    b>Campylobacter jejuni is a leading cause of foodborne illness in industrialized countries. This pathogen exhibits significant strain-to-strain variability, which results in differences in virulence potential and clinical presentations...
  31. pmc Colonization factors of Campylobacter jejuni in the chicken gut
    David Hermans
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Res 42:82. 2011
    ..jejuni identified to date. These factors may contribute to our understanding on how C. jejuni survival and colonization in chicks is mediated, as well as provide potential targets for effective subunit vaccine development...
  32. ncbi A single bifunctional UDP-GlcNAc/Glc 4-epimerase supports the synthesis of three cell surface glycoconjugates in Campylobacter jejuni
    Stéphane Bernatchez
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada
    J Biol Chem 280:4792-802. 2005
    ..cell-surface carbohydrates (lipooligosaccharide, capsule, and glycoprotein N-linked heptasaccharide) of Campylobacter jejuni NCTC 11168 contain Gal and/or GalNAc residues...
  33. ncbi Interaction of CmeABC and CmeDEF in conferring antimicrobial resistance and maintaining cell viability in Campylobacter jejuni
    Masato Akiba
    Department of Microbiology and Preventive Medicine, Iowa State University, Ames, IA 50011, USA
    J Antimicrob Chemother 57:52-60. 2006
    To determine the role of CmeDEF in conferring antimicrobial resistance in Campylobacter jejuni and examine the interaction of CmeABC and CmeDEF in mediating antimicrobial resistance and maintaining cell viability.
  34. pmc Genomic characterization of Campylobacter jejuni strain M1
    Carsten Friis
    Department of Systems Biology, The Technical University of Denmark, Lyngby, Denmark
    PLoS ONE 5:e12253. 2010
    b>Campylobacter jejuni strain M1 (laboratory designation 99/308) is a rarely documented case of direct transmission of C. jejuni from chicken to a person, resulting in enteritis. We have sequenced the genome of C...
  35. pmc Epidermal growth factor inhibits Campylobacter jejuni-induced claudin-4 disruption, loss of epithelial barrier function, and Escherichia coli translocation
    Jennifer M Lamb-Rosteski
    Department of Biological Sciences, Inflammation Research Network, University of Calgary, 2500 University Dr N W, Calgary, Alberta T2N 1N4, Canada
    Infect Immun 76:3390-8. 2008
    b>Campylobacter jejuni is a leading cause of acute bacterial enteritis in humans. Poultry serves as a major reservoir of C. jejuni and is thought to act as a principal vehicle of transmission to humans...
  36. ncbi Correlation between invasion of Caco-2 eukaryotic cells and colonization ability in the chick gut in Campylobacter jejuni
    I Hanel
    Federal Research Centre for Virus Diseases of Animals, Institute of Molecular Pathogenesis, Jena, Naumburger Str 96a, 07743 Jena, Germany
    Vet Microbiol 101:75-82. 2004
    ..The characterization of the flagellin gene of the used C. jejuni strains resulted in eight flaA types. There was no association between flaA type and invasion or colonization ability in the chick gut...
  37. ncbi Campylobacter jejuni response to human mucin MUC2: modulation of colonization and pathogenicity determinants
    Quoc V Tu
    School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia
    J Med Microbiol 57:795-802. 2008
    b>Campylobacter jejuni is the main cause of bacterial acute gastroenteritis worldwide. In its colonization of the host intestinal tract, it encounters secreted mucins in the mucus layer and surface mucins in the epithelial cells...
  38. pmc Gene expression profiling of the local cecal response of genetic chicken lines that differ in their susceptibility to Campylobacter jejuni colonization
    Xianyao Li
    Department of Poultry Science, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 5:e11827. 2010
    b>Campylobacter jejuni (C. jejuni) is one of the most common causes of human bacterial enteritis worldwide primarily due to contaminated poultry products. Previously, we found a significant difference in C...
  39. ncbi Reduction of fumarate, mesaconate and crotonate by Mfr, a novel oxygen-regulated periplasmic reductase in Campylobacter jejuni
    Edward Guccione
    Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S102TN, UK
    Environ Microbiol 12:576-91. 2010
    ..We show that the Campylobacter jejuni mfrABE operon is transcribed from a single promoter, with the mfrA gene preceded by a small open reading-..
  40. pmc Comparison of molecular typing methods useful for detecting clusters of Campylobacter jejuni and C. coli isolates through routine surveillance
    Clifford G Clark
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    J Clin Microbiol 50:798-809. 2012
    ..We have compared the characteristics of five molecular typing methods on Campylobacter jejuni and C...
  41. pmc Contribution of conserved ATP-dependent proteases of Campylobacter jejuni to stress tolerance and virulence
    Marianne Thorup Cohn
    Department of Veterinary Pathobiology, Faculty of Life Sciences, Stigbøjlen 4, DK 1870 Frederiksberg C, Denmark
    Appl Environ Microbiol 73:7803-13. 2007
    ..We constructed mutants in the lon and clpP genes of the food-borne human pathogen Campylobacter jejuni and found that the growth of both mutants was impaired at high temperature, a condition known to increase ..
  42. ncbi Poultry as a host for the zoonotic pathogen Campylobacter jejuni
    David Hermans
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium
    Vector Borne Zoonotic Dis 12:89-98. 2012
    ..Disease in humans is mainly caused by the zoonotic pathogen Campylobacter jejuni. Due to its wide-spread occurrence in the environment, the epidemiology of Campylobacter remains poorly ..
  43. pmc Multilocus sequence types of Finnish bovine Campylobacter jejuni isolates and their attribution to human infections
    Caroline P A de Haan
    Department of Food Hygiene and Environmental Health, University of Helsinki, Agnes Sjöberginkatu, Helsinki, Finland
    BMC Microbiol 10:200. 2010
    b>Campylobacter jejuni is the most common bacterial cause of human gastroenteritis worldwide. Due to the sporadic nature of infection, sources often remain unknown...
  44. ncbi Identification of Campylobacter jejuni genes involved in commensal colonization of the chick gastrointestinal tract
    David R Hendrixson
    Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    Mol Microbiol 52:471-84. 2004
    b>Campylobacter jejuni is the leading cause of bacterial gastroenteritis in humans in developed countries throughout the world...
  45. pmc Campylobacter excreted into the environment by animal sources: prevalence, concentration shed, and host association
    Iain D Ogden
    Department of Medical Microbiology, School of Medicine, University of Aberdeen, Aberdeen, UK
    Foodborne Pathog Dis 6:1161-70. 2009
    An intensive study of 443 isolates of Campylobacter jejuni and Campylobacter coli from 2031 fecal samples excreted by animal sources including cattle, sheep, and pigs, a range of wild and domesticated avian species and pets is described...
  46. pmc Identification of Campylobacter jejuni genes involved in its interaction with epithelial cells
    Veronica Novik
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Ave, New Haven, CT 06536, USA
    Infect Immun 78:3540-53. 2010
    b>Campylobacter jejuni is the leading cause of infectious gastroenteritis in industrialized nations. Its ability to enter and survive within nonphagocytic cells is thought to be very important for pathogenesis...
  47. ncbi Maximal adherence and invasion of INT 407 cells by Campylobacter jejuni requires the CadF outer-membrane protein and microfilament reorganization
    Marshall R Monteville
    School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4233, USA
    Microbiology 149:153-65. 2003
    The binding of Campylobacter jejuni to fibronectin (Fn), a component of the extracellular matrix, is mediated by a 37 kDa outer-membrane protein termed CadF for Campylobacter adhesion to fibronectin. The specificity of C...
  48. ncbi Molecular and spatial epidemiology of human campylobacteriosis: source association and genotype-related risk factors
    P Mullner
    Molecular Epidemiology and Veterinary Public Health Laboratory, Hopkirk Research Institute, Massey University, Palmerston North, New Zealand
    Epidemiol Infect 138:1372-83. 2010
    ..This study investigated the epidemiology of Campylobacter jejuni at the genotype-level over a 3-year period between 2005 and 2008 using multilocus sequence typing...
  49. pmc Gamma-glutamyl transpeptidase has a role in the persistent colonization of the avian gut by Campylobacter jejuni
    If H A Barnes
    Veterinary Laboratories Agency Weybridge, Woodham Lane, New Haw, Addlestone, Surrey, KT15 3NB, UK
    Microb Pathog 43:198-207. 2007
    The contribution of gamma-glutamyl transpeptidase (GGT) to Campylobacter jejuni virulence and colonization of the avian gut has been investigated. The presence of the ggt gene in C...
  50. ncbi Functional characterization of the twin-arginine translocation system in Campylobacter jejuni
    Gireesh Rajashekara
    Food Animal Health Research Program, Ohio Agricultural Research Development Center, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, Ohio 44691, USA
    Foodborne Pathog Dis 6:935-45. 2009
    ..Most human cases are due to Campylobacter jejuni that is commonly found in the gastrointestinal tract of chickens...
  51. pmc Functional characterization of flagellin glycosylation in Campylobacter jejuni 81-176
    Cheryl P Ewing
    Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
    J Bacteriol 191:7086-93. 2009
    The major flagellin of Campylobacter jejuni strain 81-176, FlaA, has been shown to be glycosylated at 19 serine or threonine sites, and this glycosylation is required for flagellar filament formation...
  52. ncbi Campylobacter jejuni: molecular biology and pathogenesis
    Kathryn T Young
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Rev Microbiol 5:665-79. 2007
    b>Campylobacter jejuni is a foodborne bacterial pathogen that is common in the developed world. However, we know less about its biology and pathogenicity than we do about other less prevalent pathogens. Interest in C...
  53. ncbi Immunoproliferative small intestinal disease associated with Campylobacter jejuni
    Marc Lecuit
    Hopital Avicenne, Paris, France
    N Engl J Med 350:239-48. 2004
    ..Early-stage disease responds to antibiotics, suggesting a bacterial origin. We attempted to identify a causative agent...
  54. ncbi Campylobacter sugars sticking out
    Patricia Guerry
    Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Trends Microbiol 16:428-35. 2008
    The amazing repertoire of glycoconjugates that are found in Campylobacter jejuni includes lipooligosaccharides mimicking human glycolipids, capsular polysaccharides with complex and unusual sugars, and proteins that are post-..
  55. ncbi A role for Campylobacter jejuni-induced enteritis in inflammatory bowel disease?
    Lisa D Kalischuk
    Agriculture and Agri Food Canada, Lethbridge, Canada
    Am J Physiol Gastrointest Liver Physiol 298:G1-9. 2010
    ..In this review, we examine how interactions between the common enteric pathogen Campylobacter jejuni (C...
  56. ncbi TLR4-mediated sensing of Campylobacter jejuni by dendritic cells is determined by sialylation
    Mark L Kuijf
    Department of Neurology, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands
    J Immunol 185:748-55. 2010
    In Guillain-Barré syndrome (GBS), ganglioside mimicry of Campylobacter jejuni lipo-oligosaccharide (LOS) drives the production of cross-reactive Abs to peripheral nerve gangliosides. We determined whether sialic acid residues in C...
  57. pmc Host-pathogen interactions in Campylobacter infections: the host perspective
    Riny Janssen
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Clin Microbiol Rev 21:505-18. 2008
    ..Such studies combined with better integration of host and pathogen research driven by epidemiological findings may truly advance our understanding of Campylobacter infection in humans...
  58. pmc A Campylobacter jejuni znuA orthologue is essential for growth in low-zinc environments and chick colonization
    Lindsay M Davis
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, 48109, USA
    J Bacteriol 191:1631-40. 2009
    b>Campylobacter jejuni infection is a leading cause of bacterial gastroenteritis in the United States and is acquired primarily through the ingestion of contaminated poultry products. Here, we describe the C...
  59. pmc Activation of human and chicken toll-like receptors by Campylobacter spp
    Marcel R de Zoete
    Department of Infectious Diseases and Immunology, Utrecht University, P O Box 80 165, 3508 TD Utrecht, The Netherlands
    Infect Immun 78:1229-38. 2010
    ..The results suggest that differences in bacterial cell wall integrity and in TLR responses to Campylobacter LOS and/or DNA may contribute to the distinct clinical manifestation between the species...
  60. ncbi Amino acid-dependent growth of Campylobacter jejuni: key roles for aspartase (AspA) under microaerobic and oxygen-limited conditions and identification of AspB (Cj0762), essential for growth on glutamate
    Edward Guccione
    Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Mol Microbiol 69:77-93. 2008
    Amino acids are key carbon and energy sources for the asaccharolytic food-borne human pathogen Campylobacter jejuni. During microaerobic growth in amino acid rich complex media, aspartate, glutamate, proline and serine are the only amino ..
  61. ncbi Campylobacter jejuni: a brief overview on pathogenicity-associated factors and disease-mediating mechanisms
    Javid I Dasti
    Institute of Medical Microbiology, University Medical Centre Göttingen, Kreuzbergring 57, D 37075 Gottingen, Germany
    Int J Med Microbiol 300:205-11. 2010
    b>Campylobacter jejuni has long been recognized as a cause of bacterial food-borne illness, and surprisingly, it remains the most prevalent bacterial food-borne pathogen in the industrial world to date...
  62. pmc Different contributions of HtrA protease and chaperone activities to Campylobacter jejuni stress tolerance and physiology
    Kristoffer T Baek
    Department of Veterinary Disease Biology, University of Copenhagen, Frederiksberg C, Denmark
    Appl Environ Microbiol 77:57-66. 2011
    The microaerophilic bacterium Campylobacter jejuni is the most common cause of bacterial food-borne infections in the developed world...
  63. ncbi Campylobacter jejuni Infections: update on emerging issues and trends
    B M Allos
    Department of Preventive Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Clin Infect Dis 32:1201-6. 2001
    Infection with Campylobacter jejuni is one of the most common causes of gastroenteritis worldwide; it occurs more frequently than do infections caused by Salmonella species, Shigella species, or Escherichia coli O157:H7...
  64. ncbi Infectious origins of, and molecular mimicry in, Guillain-Barré and Fisher syndromes
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    Lancet Infect Dis 1:29-37. 2001
    ..characterised by limb weakness and areflexia, is the prototype of postinfectious autoimmune diseases, and Campylobacter jejuni is the most frequent antecedent pathogen...
  65. pmc Phase variation of Campylobacter jejuni 81-176 lipooligosaccharide affects ganglioside mimicry and invasiveness in vitro
    Patricia Guerry
    Enteric Diseases Program, Naval Medical Research Center, Silver Spring, Maryland 20910, USA
    Infect Immun 70:787-93. 2002
    The outer cores of the lipooligosaccharides (LOS) of many strains of Campylobacter jejuni mimic human gangliosides in structure. A population of cells of C...
  66. pmc Effects of sequential Campylobacter jejuni 81-176 lipooligosaccharide core truncations on biofilm formation, stress survival, and pathogenesis
    Mizue Naito
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, V6T 1Z3 Canada
    J Bacteriol 192:2182-92. 2010
    b>Campylobacter jejuni is a highly prevalent human pathogen for which pathogenic and stress survival strategies remain relatively poorly understood. We previously found that a C...
  67. pmc Macrolide resistance in Campylobacter jejuni and Campylobacter coli: molecular mechanism and stability of the resistance phenotype
    Amera Gibreel
    Department of Medical Microbiology and Immunology, 1 28 Medical Sciences Building, University of Alberta, Edmonton, Alberta, T6G 2H7 Canada
    Antimicrob Agents Chemother 49:2753-9. 2005
    ..The isolates were identified as Campylobacter jejuni or Campylobacter coli based on the results of the hippurate biochemical test in addition to five PCR-based ..
  68. pmc Allelic diversity and recombination in Campylobacter jejuni
    S Suerbaum
    Institut fur Hygiene und Mikrobiologie der Universitat Wurzburg, D 97080 Wurzburg, Germany
    J Bacteriol 183:2553-9. 2001
    The allelic diversity and population structure of Campylobacter jejuni were studied by multilocus nucleotide sequence analysis. Sequences from seven housekeeping genes were obtained from 32 C...
  69. pmc Genomic characterization of the Guillain-Barre syndrome-associated Campylobacter jejuni ICDCCJ07001 Isolate
    Maojun Zhang
    Department of Communicable Disease Diagnostics, Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Beijing, China
    PLoS ONE 5:e15060. 2010
    b>Campylobacter jejuni ICDCCJ07001 (HS:41, ST2993) was isolated from a Guillain-Barré syndrome (GBS) patient during a 36-case GBS outbreak triggered by C. jejuni infections in north China in 2007...
  70. pmc Atypical roles for Campylobacter jejuni amino acid ATP binding cassette transporter components PaqP and PaqQ in bacterial stress tolerance and pathogen-host cell dynamics
    Ann E Lin
    The University of British Columbia, Department of Microbiology and Immunology, Life Sciences Centre, 2350 Health Sciences Mall, Vancouver, British Columbia, V6T 1Z3, Canada
    Infect Immun 77:4912-24. 2009
    b>Campylobacter jejuni is a human pathogen causing severe diarrheal disease; however, our understanding of the survival of C. jejuni during disease and transmission remains limited. Amino acid ATP binding cassette (AA-ABC) transporters in C...
  71. ncbi A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni
    Matthias Zilbauer
    Infectious Diseases and Microbiology Unit, Institute of Child Health, 30 Guilford St, London WC1N 1EH, UK
    Cell Microbiol 9:2404-16. 2007
    b>Campylobacter jejuni is the foremost cause of bacterial-induced diarrhoeal disease worldwide. Although it is well established that C...
  72. ncbi Mass spectrometric characterization of the Campylobacter jejuni adherence factor CadF reveals post-translational processing that removes immunogenicity while retaining fibronectin binding
    Nichollas E Scott
    School of Molecular and Microbial Biosciences, The University of Sydney, Sydney 2006, Australia
    Proteomics 10:277-88. 2010
    b>Campylobacter jejuni is a major gastrointestinal pathogen that colonizes host mucosa via interactions with extracellular matrix proteins, such as fibronectin (Fn)...
  73. ncbi Beneficial effect of Bupleurum polysaccharides on autoimmune disease induced by Campylobacter jejuni in BALB/c mice
    Zheng Wang
    Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 200032, China
    J Ethnopharmacol 124:481-7. 2009
    ..This study was to determine whether the crude polysaccharides (BPs) isolated from the roots of Bupleurum smithii var. parvifolium, had beneficial effects on autoimmune disease...
  74. pmc Differential carbohydrate recognition by Campylobacter jejuni strain 11168: influences of temperature and growth conditions
    Christopher J Day
    Institute for Glycomics, Griffith University Gold Coast Campus, Queensland, Australia
    PLoS ONE 4:e4927. 2009
    The pathogenic clinical strain NCTC11168 was the first Campylobacter jejuni strain to be sequenced and has been a widely used laboratory model for studying C. jejuni pathogenesis. However, continuous passaging of C...
  75. ncbi Campylobacter colonization of the chicken induces a proinflammatory response in mucosal tissues
    Christopher K Smith
    Institute for Animal Health, Compton, Berkshire, UK
    FEMS Immunol Med Microbiol 54:114-21. 2008
    b>Campylobacter jejuni is a major cause of human inflammatory enteritis, but colonizes the gastrointestinal tract of poultry to a high level in a commensal manner. In vitro, C...
  76. pmc Genotype and antibiotic resistance analyses of Campylobacter isolates from ceca and carcasses of slaughtered broiler flocks
    Simone E Wirz
    Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
    Appl Environ Microbiol 76:6377-86. 2010
    To obtain genetic information about Campylobacter jejuni and Campylobacter coli from broilers and carcasses at slaughterhouses, we analyzed and compared 340 isolates that were collected in 2008 from the cecum right after slaughter or from ..
  77. ncbi Isolation of motile and non-motile insertional mutants of Campylobacter jejuni: the role of motility in adherence and invasion of eukaryotic cells
    R Yao
    Enteric Diseases Program, Naval Medical Research Institute Annex, Rockville, Maryland 20852
    Mol Microbiol 14:883-93. 1994
    ..organisms has been adapted from Haemophilus influenzae and applied to the study of the pathogenesis of Campylobacter jejuni. A series of kanamycin-resistant insertional mutants of C...
  78. pmc Influence of season and geography on Campylobacter jejuni and C. coli subtypes in housed broiler flocks reared in Great Britain
    F Jorgensen
    Health Protection Agency, Microbiology Services, Food, Water and Environmental Microbiology Network, Porton Down, Salisbury SP4 0JG, United Kingdom
    Appl Environ Microbiol 77:3741-8. 2011
    Geographical and seasonal variation in the incidence and prevalence of Campylobacter jejuni and C. coli in housed broiler flocks reared in Great Britain in 2004 to 2006 was investigated in this study...
  79. ncbi Roles of the twin-arginine translocase and associated chaperones in the biogenesis of the electron transport chains of the human pathogen Campylobacter jejuni
    Andrew Hitchcock
    Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Microbiology 156:2994-3010. 2010
    The zoonotic pathogen Campylobacter jejuni NCTC 11168 uses a complex set of electron transport chains to ensure growth with a variety of electron donors and alternative electron acceptors, some of which are known to be important for host ..
  80. pmc Characterization of the specific interaction between sialoadhesin and sialylated Campylobacter jejuni lipooligosaccharides
    Astrid P Heikema
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands
    Infect Immun 78:3237-46. 2010
    In Campylobacter jejuni-induced Guillain-Barré syndrome (GBS), molecular mimicry between C...
  81. pmc Genetic diversity in Campylobacter jejuni is associated with differential colonization of broiler chickens and C57BL/6J IL10-deficient mice
    David L Wilson
    National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48823, USA
    Microbiology 156:2046-57. 2010
    Previous studies have demonstrated that Campylobacter jejuni, the leading causative agent of bacterial food-borne disease in the USA, exhibits high-frequency genetic variation that is associated with changes in cell-surface antigens and ..
  82. pmc High-resolution melting system to perform multilocus sequence typing of Campylobacter jejuni
    Simon Levesque
    Department of Microbiology and Infectious Diseases, Faculté de médecine et des sciences de la santé de l Université de Sherbrooke, Sherbrooke, Quebec, Canada
    PLoS ONE 6:e16167. 2011
    ..We evaluated the potential of high resolution melting (HRM) to identify known MLST alleles of Campylobacter jejuni at reduced cost and time...
  83. pmc Probiotic colonization of the adherent mucus layer of HT29MTXE12 cells attenuates Campylobacter jejuni virulence properties
    Abofu Alemka
    School of Medicine and Medical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Infect Immun 78:2812-22. 2010
    ..In this study, we have characterized the interaction of Campylobacter jejuni with the E12 cell line and exploited its unique mucus layer to examine the potential efficacy of probiotic ..
  84. ncbi Identification and molecular cloning of a gene encoding a fibronectin-binding protein (CadF) from Campylobacter jejuni
    M E Konkel
    Department of Microbiology, Washington State University, Pullman 99164 4233, USA
    Mol Microbiol 24:953-63. 1997
    b>Campylobacter jejuni, a Gram-negative bacterium, is a common cause of gastrointestinal disease. By analogy with other enteric pathogens such as Salmonella and Shigella, the ability of C...
  85. ncbi Transcription of sigma54-dependent but not sigma28-dependent flagellar genes in Campylobacter jejuni is associated with formation of the flagellar secretory apparatus
    David R Hendrixson
    Unit for Laboratory Animal Medicine, University of Michigan Medical School, 5641 Medical Science II, Box 0620, Ann Arbor, MI 48109 0620, USA
    Mol Microbiol 50:687-702. 2003
    We performed a genetic analysis of flagellar regulation in Campylobacter jejuni, from which we elucidated key portions of the flagellar transcriptional cascade in this bacterium. For this study, we developed a reporter gene system for C...
  86. pmc Association of Campylobacter jejuni Cj0859c gene (fspA) variants with different C. jejuni multilocus sequence types
    C P A de Haan
    Department of Food Hygiene and Environmental Health, P O Box 66, FI 00014 University of Helsinki, Helsinki, Finland
    Appl Environ Microbiol 76:6942-3. 2010
    Cj0859c variants fspA1 and fspA2 from 669 human, poultry, and bovine Campylobacter jejuni strains were associated with certain hosts and multilocus sequence typing (MLST) types...
  87. pmc The dual-functioning fumarate reductase is the sole succinate:quinone reductase in Campylobacter jejuni and is required for full host colonization
    Rebecca A Weingarten
    Department of Microbiology, North Carolina State University, Campus Box 7615, Raleigh, NC 27695, USA
    J Bacteriol 191:5293-300. 2009
    b>Campylobacter jejuni encodes all the enzymes necessary for a complete oxidative tricarboxylic acid (TCA) cycle. Because of its inability to utilize glucose, C...
  88. ncbi Environmental survival mechanisms of the foodborne pathogen Campylobacter jejuni
    C Murphy
    Teagasc, Moorepark Food Research Centre, Moorepark, Fermoy, Co Cork, Ireland
    J Appl Microbiol 100:623-32. 2006
    ..This review summarizes the mechanisms by which Campylobacter spp. adapt to stress conditions and thereby increase their ability to survive on food and in the environment...
  89. pmc Campylobacter jejuni FlpA binds fibronectin and is required for maximal host cell adherence
    Michael E Konkel
    Department of Microbiology, School of Molecular Biosciences, Washington State University, Pullman, Washington, USA
    J Bacteriol 192:68-76. 2010
    b>Campylobacter jejuni is one of the most frequent bacterial causes of food-borne gastrointestinal disease in developed countries. Previous work indicates that the binding of C...
  90. pmc Modification of the Campylobacter jejuni flagellin glycan by the product of the Cj1295 homopolymeric-tract-containing gene
    Paul Hitchen
    Division of Molecular Biosciences, Faculty of Natural Science, Imperial College, London SW7 2AY, UK
    Microbiology 156:1953-62. 2010
    The Campylobacter jejuni flagellin protein is O-glycosylated with structural analogues of the nine-carbon sugar pseudaminic acid. The most common modifications in the C...
  91. ncbi Genetic diversity among Campylobacter jejuni isolates from pets in Ireland
    E Acke
    School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
    Vet Rec 166:102-6. 2010
    b>Campylobacter jejuni isolates obtained from pets housed in shelters and in private households were subtyped by fla typing (using DdeI and HinfI restriction enzymes) and pulsed-field gel electrophoresis (PFGE) techniques...
  92. pmc Carbohydrate mimicry between human ganglioside GM1 and Campylobacter jejuni lipooligosaccharide causes Guillain-Barre syndrome
    Nobuhiro Yuki
    Department of Neurology, Institute for Medical Science, Dokkyo University School of Medicine, Shimotsuga, Tochigi 321 0293, Japan
    Proc Natl Acad Sci U S A 101:11404-9. 2004
    ..frequent cause of acute neuromuscular paralysis, occurs 1-2 wk after various infections, in particular, Campylobacter jejuni enteritis...
  93. pmc CapA, an autotransporter protein of Campylobacter jejuni, mediates association with human epithelial cells and colonization of the chicken gut
    Sami S A Ashgar
    Queen s Medical Centre, University Hospital, Nottingham, NG7 2UH, UK
    J Bacteriol 189:1856-65. 2007
    Two putative autotransporter proteins, CapA and CapB, were identified in silico from the genome sequence of Campylobacter jejuni NCTC11168...
  94. pmc Campylobacter jejuni survives within epithelial cells by avoiding delivery to lysosomes
    Robert O Watson
    Section of Microbial Pathogenesis, Yale University, School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 4:e14. 2008
    b>Campylobacter jejuni is one of the major causes of infectious diarrhea world-wide, although relatively little is know about its mechanisms of pathogenicity...
  95. pmc The CprS sensor kinase of the zoonotic pathogen Campylobacter jejuni influences biofilm formation and is required for optimal chick colonization
    Sarah L Svensson
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    Mol Microbiol 71:253-72. 2009
    b>Campylobacter jejuni, a prevalent cause of bacterial gastroenteritis, must adapt to different environments to be a successful pathogen. We previously identified a C...
  96. pmc Development and application of an insertional system for gene delivery and expression in Campylobacter jejuni
    A V Karlyshev
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, University of London, Keppel St, London WC1E 7HT, United Kingdom
    Appl Environ Microbiol 71:4004-13. 2005
    The genetic investigation of Campylobacter jejuni, an important gastrointestinal pathogen, has been hampered by the lack of an efficient system for introduction of exogenous genetic information, as commonly used vectors designed for ..
  97. ncbi Bacterial secreted proteins are required for the internaliztion of Campylobacter jejuni into cultured mammalian cells
    M E Konkel
    Department of Microbiology, Washington State University, Pullman, Washington 99164 4233, USA
    Mol Microbiol 32:691-701. 1999
    Presented here is the first evidence that Campylobacter jejuni secrete proteins upon co-cultivation with host cells and in INT 407 cell-conditioned medium. A C...
  98. ncbi RpoD promoters in Campylobacter jejuni exhibit a strong periodic signal instead of a -35 box
    Lise Petersen
    Center for Biological Sequence Analysis, Technical University of Denmark, DK 2800 Lyngby, Denmark
    J Mol Biol 326:1361-72. 2003
    ..used a hidden Markov model (HMM) to identify the consensus sequence of the RpoD promoters in the genome of Campylobacter jejuni. The identified promoter consensus sequence is unusual compared to other bacteria, in that the region ..
  99. pmc Effect of Campylobacter-specific maternal antibodies on Campylobacter jejuni colonization in young chickens
    Orhan Sahin
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio 44691, USA
    Appl Environ Microbiol 69:5372-9. 2003
    ....
  100. ncbi The Campylobacter jejuni general glycosylation system is important for attachment to human epithelial cells and in the colonization of chicks
    A V Karlyshev
    London School of Hygiene and Tropical Medicine, University of London, Keppel Street, London EC1A 7HT, UK
    Microbiology 150:1957-64. 2004
    It has recently been shown that the enteropathogen Campylobacter jejuni has an N-linked general protein glycosylation pathway (Pgl) that modifies many of the organism's proteins...
  101. pmc Detection and characterization of autoagglutination activity by Campylobacter jejuni
    N Misawa
    Division of Infectious Diseases, Vanderbilt University School of Medicine, A 3310 Medical Center North, Nashville, Tennessee 37232, USA
    Infect Immun 68:6168-75. 2000
    ..b>Campylobacter jejuni strains also show AAG, but this property varies considerably among strains...

Research Grants62

  1. Salmonella Vaccines Against Bacterial Enteropathogens
    Roy Curtiss; Fiscal Year: 2013
    ..and other entero-pathogens such as Yersinia sp., Vibrio cholerae, Campylobacter jejuni, Helicobacter pylori, Listeria monocytogenes, Clostridium perfringens and C. difficile...
  2. Research and Development of a Novel System to Produce Polysaccharide Conjugate Va
    Peng George Wang; Fiscal Year: 2013
    ..Oligosaccharyltransferase (PglB) from Campylobacter jejuni, which was first discovered by Markus Aebi in 2002, later developed by GlycoVaxyn LLC, was found to be able ..
  3. Campylobacter jejuni outer membrane protein vaccine
    Stuart Thompson; Fiscal Year: 2009
    b>Campylobacter jejuni is the leading cause of bacterial gastroenteritis in the U.S., and has been classified by the NIH as a Category B Bioterrorism Agent due to its ability to cause food-borne and water-borne outbreaks...
  4. 16th international conference on Campylobacter, Helicobacter and related organism
    Irving Nachamkin; Fiscal Year: 2011
    ..b>Campylobacter jejuni is now firmly established as a major cause of bacterial diarrhea in both developed and developing countries...
  5. Campylbacter jejuni flagellar regulation and synthesis
    David R Hendrixson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Campylobacter jejuni is a leading cause of gastroenteritis in humans in the United States and in other countries throughout the world. According to the Centers for Disease Control, C...
  6. Blood Transcriptional Biomarker Profiles for Category B Pathogens
    Damien Chaussabel; Fiscal Year: 2013
    ..France) and diarrheal diseases (Escherichia coli, pathogenic Vibrio strains, Shigella spp, Salmonella, Campylobacter jejuni and Caliciviruses / Department of Molecular Biomedicine, CINVESTAV&Microbiology Research Laboratory at ..
  7. CHEMOTACTIC SENSORY TRANSDUCTION IN BACILLUS SUBTILIS
    George W Ordal; Fiscal Year: 2012
    ..subtilis chemotaxis mechanism. Furthermore, many Gram-negative pathogens including Burkholderia sp., Campylobacter jejuni, Helicobacter sp...
  8. Molecular Mechanisms of Campylobacter Jejuni-induced Pathogenesis
    Christian Jobin; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The Gram-negative invasive bacterium Campylobacter jejuni (C...
  9. Antimicrobial peptide resistance in Campylobacter jejuni
    Jun Lin; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Campylobacter jejuni is the leading bacterial cause of human enteritis in the United States. Contaminated poultry meats are considered a significant source for human Campylobacter infections...
  10. Murine models to test parasite products as cures for Inflammatory Bowel Disease
    Linda S Mansfield; Fiscal Year: 2010
    ..From 1990-2003, she focused on finding naturally occurring animal models for Campylobacter jejuni and Cyst forming coccidia (Sarcocystis neurona, etc...
  11. Structural Components of the Campylobacter jejuni Polar Flagellar Motor
    David R Hendrixson; Fiscal Year: 2013
    ..cryo-tomography, we have identified three disk structures associated with the polar flagellar motor of Campylobacter jejuni, a leading cause of gastroenteritis in humans in the United States and in other countries throughout the ..
  12. Elucidation of a bacterial cell shape generating program and pathogenic functions
    NINA REDA SALAMA; Fiscal Year: 2013
    ..are well conserved among curved to helical Proteobacteria including several other pathogens such as Campylobacter jejuni and Vibrio cholerae...
  13. Bacterial Surface Structures of Helicobacter Pylori and Campylobacter Jejuni
    MICHAEL STEPHEN TRENT; Fiscal Year: 2013
    ..proposal is to unravel the molecular mechanisms by which two pathogenic organisms, Helicobacter pylori and Campylobacter jejuni, modify their LPS structure and the role these modifications play in virulence...
  14. Capsule conjugate vaccines against ETEC and Campylobacter
    Patricia Guerry; Fiscal Year: 2013
    ..proposal is that multivalent vaccines can be generated against enterotoxigenic Escherichia coli (ETEC) and Campylobacter jejuni by conjugation of LTB and antigenically distinct colonization factor antigens (CFA's or fimbriae) from ..
  15. Inhibition of Glycoprotein Biosynthesis in Gram-Negative Pathogens
    Barbara Imperiali; Fiscal Year: 2013
    ..of UDP-GlcNAc into UDP-diNAcBac in the N-linked protein glycosylation pathway of the enteropathogen Campylobacter jejuni. Phenotypic studies establish that UDP-diNAcBac is an obligatory intermediate in the pathway that ..
  16. S. typhimiurium Vaccine Against Bacterial Enteropathogens
    Roy Curtiss; Fiscal Year: 2007
    ..Escherichia coli and Shigella species, and less closely related enteropathogens such as Vibrio cholerae, Campylobacter jejuni and Listeria monocytogenes...
  17. Genetic adaptation in Campylobacter: mechanisms and impacts on human health
    John E Linz; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The food borne pathogen Campylobacter jejuni (CJ) causes between 2.5 and 3 million human disease cases and approximately 100 deaths annually at an estimated cost of between 1.6 and 6.2 billion dollars...
  18. Molecular mechanisms underlying Campylobacter jejuni cellular invasion
    Michael E Konkel; Fiscal Year: 2011
    Project Summary Campylobacter jejuni [unreadable] [unreadable]a NIAID Category B Priority Pathogen[unreadable] [unreadable] is a leading bacterial cause of human gastrointestinal disease worldwide. While the clinical presentation of C...
  19. Synthesis of Complex Carbohydrates.
    Hien M Nguyen; Fiscal Year: 2013
    ..glycosylation methodology will be applied to the synthesis of bioactive carbohydrate targets, including Campylobacter jejuni N-linked glycan (Specific Aim 2) which can be used to block Campylobacter jejuni adherence to human gastric ..
  20. ESCHERICHIA COLI LT-RELATED ENTEROTOXINS
    RICHARD FINKELSTEIN; Fiscal Year: 1991
    ..coli strain of bovine origin; and cholera/coli related enterotoxins from Salmonellae, Aeromonas hydrophila, Campylobacter jejuni, Vibrio cholerae non-01, and V. mimicus. For others, the evidence is thus far only circumstantial...
  21. Glycosylation of full-length antibodies in Escherichia coli
    ADAM FISHER; Fiscal Year: 2009
    ..coli-derived immunoglobulins (IgGs). Recently, it was discovered that the Campylobacter jejuni asparagine-linked (N-linked) protein glycosylation pathway can be functionally transferred into E...
  22. Humanizing N-linked glycosylation in Escherichia coli
    ADAM FISHER; Fiscal Year: 2009
    ..Recently, however, it has been reported that the Campylobacter jejuni asparagine-linked (Nlinked) protein glycosylation system can be functionally transferred into Escherichia ..
  23. Campylobacter jejuni proteins induced at 37C
    Stuart Thompson; Fiscal Year: 2007
    b>Campylobacter jejuni is the leading cause of severe bacterial gastroenteritis in the U.S., and has been classified as a food-borne Category B Bioterrorism agent by the NIH...
  24. Campylobacter colonization and virulence determinants
    Alain Stintzi; Fiscal Year: 2007
    ..This proposal focuses on the characterization of Campylobacter jejuni colonization and virulence factors...
  25. Campylobacter jejuni and Reactive Nitrogen Species
    Nicole Iovine; Fiscal Year: 2007
    ..the relationship between host-derived reactive nitrogen species and the disease-causing potential of Campylobacter jejuni. This Gram-negative organism is the most common cause of food-borne bacterial diarrheal disease in the ..
  26. Phenotype MicroArray Analysis of Fastidious Pathogens
    Barry Bochner; Fiscal Year: 2004
    ..pylori (Hp) (implicated in peptic ulcer disease and gastric cancer), and the intestinal pathogen Campylobacter jejuni (Cj) (a very common cause of gastroenteritis, and rheumatoid arthritis, and also (with some strains) of an ..
  27. IMMUNOBIOLOGY OF CAMPYLOBACTER JEJUNI
    Irving Nachamkin; Fiscal Year: 1990
    ..Campylobacter flagellin, the major protein of the flagella filament, is the major immunodominant protein of Campylobacter jejuni in patients will campylobacter enteritis...
  28. Potentiating antibiotics against Campylobacter by inhibiting efflux
    Qijing Zhang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Campylobacter jejuni is a major enteric pathogen and is responsible for a large number of gastroenteritis worldwide...
  29. Quorum-sensing mechanisms of Campylobacter
    PAUL PLUMMER; Fiscal Year: 2009
    ..Research conducted as part of this proposal will focus on the quorum sensing mechanism employed by Campylobacter jejuni, a leading cause of human foodborne bacterial enteritis in the United States...
  30. MECHANISM OF INJURY IN THE GUILLAIN BARRE SYNDROME
    Tony Ho; Fiscal Year: 1999
    ..b>Campylobacter jejuni infection is an important antecedent infection in both patterns of disease...
  31. Capsule conjugate vaccines against Campylobacter jejuni
    Patricia Guerry; Fiscal Year: 2010
    b>Campylobacter jejuni is a Category B agent that is one of the major bacterial causes of diarrheal disease, and there are no vaccines available...
  32. Probing the Glycan Biosynthetic Machinery of Campylobacter Jejuni.
    JERRY TROUTMAN; Fiscal Year: 2009
    ..in eukaryotic and archaeal organisms, and has recently been discovered in the gram-negative enteropathogen Campylobacter jejuni (C. jejuni). C...
  33. CHINESE PARALYTIC SYNDROME - MECHANISMS AND RELEVANCE
    GUY MC KHANN; Fiscal Year: 2001
    ..Both forms can be associated with preceding infections with Campylobacter jejuni. The immunopathology in these two forms is quite different...
  34. MAMMALIAN CELL CYCLE BLOCK BY A C JEJUNI CYTOTOXIN
    CAROL PICKETT; Fiscal Year: 1999
    DESCRIPTION (Adapted from the applicant's abstract): Campylobacter jejuni is the most common bacterial cause of diarrheal disease of humans in the United States...
  35. A Multiplex, Point-of-Care Test for Enteric Pathogens
    Bernhard Weigl; Fiscal Year: 2007
    ..platform for rapid identification of Shigella dysenteriae, Shigella toxin-producing Escherichia coli, Campylobacter jejuni, and Salmonella species simultaneously from the same clinical specimen. 3...
  36. PATHOGENESIS OF THE GUILLAIN-BARRE SYNDROMES
    John Griffin; Fiscal Year: 1999
    ..Recent advances in GBS have been propelled by the recognition that Campylobacter jejuni infection is an important antecedent, and that many individuals with GBS have anti- glycoconjugate ..
  37. Transmission of H. pylori infection in the rhesus monkey
    JAY SOLNICK; Fiscal Year: 2005
    ..pylori; 3) Determine the effects of H. pylori infection on the acquisition of Campylobacter jejuni; and 4) Determine the effects of the CagA pathogenicity island on colonization and shedding.
  38. Glycophage arrays for the discovery of biomarkers in disease
    ADAM FISHER; Fiscal Year: 2009
    ..Recently, it was discovered that the Campylobacter jejuni asparagine-linked (N-linked) protein glycosylation system can be functionally transferred into E...
  39. Broadly active inhibitors of high priority pathogens
    Sergei Gulnik; Fiscal Year: 2004
    ..1) cloning, expression and purification of recombinant DHQases from Bacillus anthracis, Yersinia pestis, Campylobacter jejuni, Vibrio cholera and Mycobacteria tuberculosis; 2) establishing DHQase inhibitor assays using the ..
  40. Campylobacter jejuni DNA methylation and gene regulation
    Stuart Thompson; Fiscal Year: 2004
    b>Campylobacter jejuni is a Category B Bioterrorism Agent as classified by the NIH...
  41. Chemokines in host defense to Campylobacter jejuni
    MICHAEL DWINELL; Fiscal Year: 2004
    ..NOT-AI-02-023, has two specific aims designed to increase our understanding of the pathogenesis of Campylobacter jejuni enterocolitis...
  42. CAMPYLOBACTER JEJUNI CYTOLETHAL DISTENDING TOXIN
    CAROL PICKETT; Fiscal Year: 2001
    DESCRIPTION (Adapted from the Applicant's Abstract): Campylobacter jejuni is currently the most common bacterial cause of diarrheal disease in humans in the United States...
  43. Campylobacter jejuni invasion genes
    GEORGE FOGG; Fiscal Year: 2006
    b>Campylobacter jejuni is a significant human enteric pathogen that is a leading cause of bacterial gastroenteritis in both the United States and worldwide...
  44. C. jejuni Cytolethal Distending Toxin Cell Interactions
    STEVEN BLANKE; Fiscal Year: 2005
    b>Campylobacter jejuni is a food and water borne pathogen responsible for severe inflammatory diarrhea in humans. C...
  45. CAMPYLOBACTER IMMUNITY IN PRIMATES
    Robert Russell; Fiscal Year: 1991
    Our studies have shown that Campylobacter jejuni (C. jejuni) is an important bacterial enteric pathogen in laboratory housed non-human primates. This enteropathogen causes colitis...
  46. CAMPYLOBACTER IMMUNITY IN PRIMATES
    Robert Russell; Fiscal Year: 1992
    Our studies have shown that Campylobacter jejuni (C. jejuni) is an important bacterial enteric pathogen in laboratory housed non-human primates. This enteropathogen causes colitis...
  47. 10TH INTERNATIONAL WORKSHOP ON CAMPYLOBACTER, HELICOBACT
    HARRY MOBLEY; Fiscal Year: 1999
    ..b>Campylobacter jejuni is now firmly established as the major cause of bacterial diarrhea in both developed and developing ..
  48. C. jejuni CDT Subunit Interactions
    CAROL PICKETT; Fiscal Year: 2004
    b>Campylobacter jejuni is currently one of the most common bacterial causes of diarrheal disease in humans in the United States...
  49. Live Attenuated Salmonella Vaccine Against Campylobacter
    Kenneth Roland; Fiscal Year: 2005
    The bacterium, Campylobacter jejuni, is a major cause of diarrheal illness in both the developed and developing world...
  50. Characterization of bacillosamine synthesis in C. jejuni
    NELSON OLIVIER; Fiscal Year: 2007
    ..to biochemical analysis resides in the biosynthesis of bacillosamine from the gram-negative enteropathogen Campylobacter jejuni. In C...
  51. Gut to Brain Pathways for Infection-Induced Anxiety
    Mark Lyte; Fiscal Year: 2005
    ..is based on the demonstration that a low-dose ("subclinical") infection with the food-borne pathogen Campylobacter jejuni induces anxiety-like behavior in orally challenged mice...
  52. Rapid Detection of Major Food-borne Pathogens
    Peixuan Zhu; Fiscal Year: 2003
    ..In Phase II the scope will be expanded to include the pathogens Listeria monocytogenes and Campylobacter jejuni and the food groups poultry and fresh produce...
  53. PATHOGENIC ROLE OF BACTERIAL SURFACE PROTEINS
    Lee Wetzler; Fiscal Year: 1990
    ..gonorrheae to Campylobacter jejuni, an invasive intestinal pathogen that only fairly recently has been discovered to be an extremely important ..
  54. Post-transcriptional regulation of virulence in Campylobacter jejuni
    Stuart A Thompson; Fiscal Year: 2010
    ABSTRACT Campylobacter jejuni is a leading bacterial cause of gastroenteritis in the United States, and is responsible for sporadic disease as well as food-borne and water-borne outbreaks. It is also a Category B Bioterrorism Agent...
  55. 14th International CHRO Workshop
    Irving Nachamkin; Fiscal Year: 2007
    ..b>Campylobacter jejuni is now[unreadable] firmly established as the major cause of bacterial diarrhea in both developed and ..
  56. 13th International Campylobacter/Helicobacter workshop
    Irving Nachamkin; Fiscal Year: 2005
    ..b>Campylobacter jejuni is now firmly established as the major cause of bacterial diarrhea in both developed and developing ..
  57. Capsular Polysaccharides of Campylobacter jejuni
    Patricia Guerry; Fiscal Year: 2010
    The major hypothesis of this proposal is that the polysaccharide capsules (CPS) of Campylobacter jejuni are virulence determinants of this important human pathogen...
  58. Pathogenesis of Campylobacter enteritis:
    MICHAEL KONKEL; Fiscal Year: 2005
    ..goal of this research is to use the knowledge gained from the identification and characterization of Campylobacter jejuni virulence determinants to reduce morbidity and mortality resulting from C. jejuni infections. C...
  59. HOST FACTORS MEDIATE INVASION BY CAMPYLOBACTER JEJUNI
    LINDA MANSFIELD; Fiscal Year: 2002
    DESCRIPTION (Adapted from the applicant's abstract): Campylobacter jejuni is the leading cause of intestinal infection in humans in the US and the world, and has been designated as an emerging disease by the US CDC...
  60. Gamma-Delta T cells and Cryptosporidiosis
    Beth Kirkpatrick; Fiscal Year: 2008
    ..These data will advance our understanding of the mucosal immune response to cryptosporidiosis, which will lead to further advances in prevention and therapy. ..
  61. Glycosylation of Campylobacter flagella
    Patricia Guerry; Fiscal Year: 2007
    b>Campylobacter jejuni is the leading cause of foodborne illness in North America and is among the major causes of bacterial diarrhea worldwide...