actinomyces

Summary

Summary: A genus of gram-positive, rod-shaped bacteria whose organisms are nonmotile. Filaments that may be present in certain species are either straight or wavy and may have swollen or clubbed heads.

Top Publications

  1. ncbi Antimicrobial susceptibility testing of Actinomyces species with 12 antimicrobial agents
    A J Smith
    Infection Research Group, Glasgow Dental Hospital, Glasgow, Scotland, UK
    J Antimicrob Chemother 56:407-9. 2005
  2. ncbi Actinomyces meyeri cutaneous actinomycosis
    María Daniela Hermida
    Department of Dermatology, Hospital Nacional Profesor Alejandro Posadas, Buenos Aires, Argentina
    Int J Dermatol 48:154-6. 2009
  3. ncbi Bacterial interactions and successions during plaque development
    Paul E Kolenbrander
    Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Periodontol 2000 42:47-79. 2006
  4. ncbi Effects of silver diamine fluoride on dentine carious lesions induced by Streptococcus mutans and Actinomyces naeslundii biofilms
    Chun Hung Chu
    The University of Hong Kong, China
    Int J Paediatr Dent 22:2-10. 2012
  5. pmc Molecular characterization of subject-specific oral microflora during initial colonization of enamel
    Patricia I Diaz
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 310, 30 Convent Dr, Bethesda, MD 20892 4350, USA
    Appl Environ Microbiol 72:2837-48. 2006
  6. ncbi Actinomyces neuii: review of an unusual infectious agent
    Alexander von Graevenitz
    Institute of Medical Microbiology, University of Zurich, Gloriastrasse 32, 8006 Zurich, Switzerland
    Infection 39:97-100. 2011
  7. ncbi Autovaccination of dairy cows to treat post partum metritis caused by Actinomyces pyogenes
    O Nolte
    Hygiene Institut, Abt Hygiene and Medizinische Mikrobiologie, Universitat Heidelberg, Im Neuenheimer Feld 324, D 69120, Heidelberg, Germany
    Vaccine 19:3146-53. 2001
  8. ncbi Protection offered by root-surface restorative materials against biofilm challenge
    H K Yip
    Faculty of Dentistry, The University of Hong Kong, Room 1A23, Prince Philip Dental Hosptial, 34 Hospital Road, Hong Kong SAR, China
    J Dent Res 86:431-5. 2007
  9. ncbi Structure of the sortase AcSrtC-1 from Actinomyces oris
    Karina Persson
    Department of Odontology, Umea University, Umea, Sweden
    Acta Crystallogr D Biol Crystallogr 67:212-7. 2011
  10. ncbi Effects of glucose and fluoride on competition and metabolism within in vitro dental bacterial communities and biofilms
    D J Bradshaw
    CAMR, Salisbury, Wilts, Port Sunlight Laboratory, Bebington, Merseyside, UK
    Caries Res 36:81-6. 2002

Detail Information

Publications217 found, 100 shown here

  1. ncbi Antimicrobial susceptibility testing of Actinomyces species with 12 antimicrobial agents
    A J Smith
    Infection Research Group, Glasgow Dental Hospital, Glasgow, Scotland, UK
    J Antimicrob Chemother 56:407-9. 2005
    This study was conducted to assess the susceptibility of human clinical isolates of Actinomyces species to 12 antimicrobial agents.
  2. ncbi Actinomyces meyeri cutaneous actinomycosis
    María Daniela Hermida
    Department of Dermatology, Hospital Nacional Profesor Alejandro Posadas, Buenos Aires, Argentina
    Int J Dermatol 48:154-6. 2009
    b>Actinomyces meyeri cutaneous actinomycosis is a very rare disease. It often results from contiguous dissemination of an underlying focus...
  3. ncbi Bacterial interactions and successions during plaque development
    Paul E Kolenbrander
    Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Periodontol 2000 42:47-79. 2006
  4. ncbi Effects of silver diamine fluoride on dentine carious lesions induced by Streptococcus mutans and Actinomyces naeslundii biofilms
    Chun Hung Chu
    The University of Hong Kong, China
    Int J Paediatr Dent 22:2-10. 2012
    ..AIM. To characterize the effects of SDF on dentine carious induced by Streptococcus mutans and Actinomyces naeslundii. DESIGN.  Thirty-two artificially demineralized human dentine blocks were inoculated: 16 with S...
  5. pmc Molecular characterization of subject-specific oral microflora during initial colonization of enamel
    Patricia I Diaz
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 310, 30 Convent Dr, Bethesda, MD 20892 4350, USA
    Appl Environ Microbiol 72:2837-48. 2006
    ..observed genera (comprising at least 5% of clone sequences in at least one of the six clone libraries) were Actinomyces, Gemella, Granulicatella, Neisseria, Prevotella, Rothia, and Veillonella...
  6. ncbi Actinomyces neuii: review of an unusual infectious agent
    Alexander von Graevenitz
    Institute of Medical Microbiology, University of Zurich, Gloriastrasse 32, 8006 Zurich, Switzerland
    Infection 39:97-100. 2011
    b>Actinomyces neuii, a species first described in 1994, has proven to be an exception in this genus on account of its aerobic growth, microscopic morphology (no branching), and the types and location of infections...
  7. ncbi Autovaccination of dairy cows to treat post partum metritis caused by Actinomyces pyogenes
    O Nolte
    Hygiene Institut, Abt Hygiene and Medizinische Mikrobiologie, Universitat Heidelberg, Im Neuenheimer Feld 324, D 69120, Heidelberg, Germany
    Vaccine 19:3146-53. 2001
    ..We therefore conclude that administration of an autovaccine leads to the activation of immunologic effector mechanisms which contribute to recovery of the diseased animals...
  8. ncbi Protection offered by root-surface restorative materials against biofilm challenge
    H K Yip
    Faculty of Dentistry, The University of Hong Kong, Room 1A23, Prince Philip Dental Hosptial, 34 Hospital Road, Hong Kong SAR, China
    J Dent Res 86:431-5. 2007
    ..A biofilm of Streptococcus mutans, Streptococcus sobrinus, Lactobacillus rhamnosus, and Actinomyces naeslundii was co-cultured for 21 days on 24 glass-ionomer cement, resin-modified glass-ionomer cement, or ..
  9. ncbi Structure of the sortase AcSrtC-1 from Actinomyces oris
    Karina Persson
    Department of Odontology, Umea University, Umea, Sweden
    Acta Crystallogr D Biol Crystallogr 67:212-7. 2011
    The crystal structure of the sortase AcSrtC-1 from the oral microorganism Actinomyces oris has been determined to 2.4 Å resolution...
  10. ncbi Effects of glucose and fluoride on competition and metabolism within in vitro dental bacterial communities and biofilms
    D J Bradshaw
    CAMR, Salisbury, Wilts, Port Sunlight Laboratory, Bebington, Merseyside, UK
    Caries Res 36:81-6. 2002
    ..pH 4.9) (paired t test, p < 0.0001). The culture was predominated by V. dispar (70%) and Actinomyces naeslundii (13%), whereas S. mutans proportions were significantly lower (t test, p = 0...
  11. pmc Spatial arrangements and associative behavior of species in an in vitro oral biofilm model
    M Guggenheim
    Institute for Oral Microbiology and General Immunology, Center for Dental and Oral Medicine and Maxillofacial Surgery, , , Switzerland
    Appl Environ Microbiol 67:1343-50. 2001
    The spatial arrangements and associative behavior of Actinomyces naeslundii, Veillonella dispar, Fusobacterium nucleatum, Streptococcus sobrinus, and Streptococcus oralis strains in an in vitro model of supragingival plaque were ..
  12. pmc Host-derived pentapeptide affecting adhesion, proliferation, and local pH in biofilm communities composed of Streptococcus and Actinomyces species
    Mirva Drobni
    Department of Odontology Cariology, Umea University, SE 901 87 Umea, and Division of Clinical Immunology, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Infect Immun 74:6293-9. 2006
    Salivary proline-rich proteins (PRPs) attach commensal Actinomyces and Streptococcus species to teeth...
  13. ncbi Salivary Actinomyces naeslundii genospecies 2 and Lactobacillus casei levels predict pregnancy outcomes
    Ananda P Dasanayake
    Department of Epidemiology and Health Promotion, New York University College of Dentistry, New York, NY 10010, USA
    J Periodontol 76:171-7. 2005
    ..Gravida's poor periodontal health is emerging as a modifiable independent risk factor for preterm delivery and low birth weight...
  14. ncbi Actinomyces odontolyticus bacteremia
    Lawrence A Cone
    Eisenhower Medical Center, Rancho Mirage, California 92270, USA
    Emerg Infect Dis 9:1629-32. 2003
    We describe two immunosuppressed female patients with fever and Actinomyces odontolyticus bacteremia, a combination documented once previously in an immunocompetent male patient...
  15. pmc Structural determinants of Actinomyces sortase SrtC2 required for membrane localization and assembly of type 2 fimbriae for interbacterial coaggregation and oral biofilm formation
    Chenggang Wu
    Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, Houston, Texas, USA
    J Bacteriol 194:2531-9. 2012
    As a pioneer colonizer of the oral cavity, Actinomyces oris expresses proteinaceous pili (also called fimbriae) to mediate the following two key events in biofilm formation: adherence to saliva deposits on enamel and interbacterial ..
  16. ncbi Regulation of urease expression of Actinomyces naeslundii in biofilms in response to pH and carbohydrate
    Y Liy
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USA
    Oral Microbiol Immunol 23:315-9. 2008
    ..b>Actinomyces naeslundii is a ureolytic bacterium that is adapted to tolerate the rapid and dramatic fluctuations in nutrient ..
  17. ncbi Effectiveness of three root canal medicaments to eliminate Actinomyces israelii from infected dentinal tubules in vitro
    N J Basson
    Oral and Dental Research Institute, School for Oral Health Sciences, University of Stellenbosch, Tygerberg
    SADJ 56:499-501. 2001
    ..to compare the effectiveness of two root canal medicaments and a chlorhexidine solution in disinfecting Actinomyces israelii-infected root canal walls and dentinal tubules in vitro...
  18. ncbi Actinomyces coleocanis sp. nov., from the vagina of a dog
    Lesley Hoyles
    School of Food Biosciences, University of Reading, Whiteknights, UK
    Int J Syst Evol Microbiol 52:1201-3. 2002
    A hitherto undescribed Actinomyces-like bacterium was isolated from the vagina of a dog...
  19. ncbi IUDs and colonization or infection with Actinomyces
    Carolyn Westhoff
    Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY 10032, USA
    Contraception 75:S48-50. 2007
    ..Approximately 7% of women using an IUD may have a finding of Actinomyces-like organisms on a Pap test...
  20. ncbi The effects of polishing methods on surface morphology, roughness and bacterial colonisation of titanium abutments
    Michele E Barbour
    Department of Oral and Dental Science, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK
    J Mater Sci Mater Med 18:1439-47. 2007
    ..Biofilms of Actinomyces naeslundii were more extensive on polished abutment surfaces...
  21. ncbi Intra-abdominal co-infection with Mycobacterium bovis and Actinomyces in an AIDS patient: the first reported case and review
    Mark Richman
    Department of Medicine, Division of Infectious Diseases, Olive View UCLA Medical Center, 14445 Olive View Dr 2B182, Sylmar, CA 91342, USA
    J Infect 55:e115-8. 2007
    The Mycobacterium tuberculous complex and Actinomyces can both cause indolent intra-abdominal infections that result in hard mass lesion(s), oftentimes fixed to underlying tissue and involving the right ileocecal fossa region...
  22. ncbi Regulation of urease gene of Actinomyces naeslundii in biofilms in response to environmental factors
    Yaling Liu
    FEMS Microbiol Lett 278:157-63. 2008
    ..of oral bacteria has a profound influence on oral biofilm pH homeostasis and oral microbial ecology, and Actinomyces naeslundii is an important ureolytic organism in the oral cavity...
  23. ncbi Transient acid-impairment of growth ability of oral Streptococcus, Actinomyces, and Lactobacillus: a possible ecological determinant in dental plaque
    M Horiuchi
    Division of Pediatric Dentistry, Tohoku University Graduate School of Dentistry, Sendai 980 8575, Japan
    Oral Microbiol Immunol 24:319-24. 2009
    ..We, therefore, investigated the effects of physiological acidification on representative caries-related bacteria...
  24. pmc Two autonomous structural modules in the fimbrial shaft adhesin FimA mediate Actinomyces interactions with streptococci and host cells during oral biofilm development
    Arunima Mishra
    Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, Houston, TX, USA
    Mol Microbiol 81:1205-20. 2011
    ..modelling, we describe here the atomic structure of distinct adhesive moieties of FimA, the shaft fimbrillin of Actinomyces type 2 fimbriae, which uniquely mediates the receptor-dependent intercellular interactions between Actinomyces ..
  25. ncbi Characterization of monoclonal antibodies for rapid identification of Actinomyces naeslundii in clinical samples
    T Thurnheer
    Institute of Oral Microbiology and General Immunology, University of Zurich, Switzerland
    FEMS Microbiol Lett 150:255-62. 1997
    ..of this study was to generate highly specific serological reagents for the quantitative identification of Actinomyces naeslundii in clinical samples, in particular dental plaque...
  26. ncbi Cell surface structures of Actinomyces israelii
    D Figdor
    Department of Microbiology, Faculty of Medicine, Monash University
    Aust Dent J 42:125-8. 1997
    b>Actinomyces israelii is the most common cause of human actinomycosis, a chronic granulomatous infection. Periapical actinomycosis involving A...
  27. ncbi Bisphosphonate-related osteonecrosis of the jaw: the role of actinomyces
    Nimesh H Naik
    Department of Medicine, Veterans Administration Western New York Healthcare System, University at Buffalo State University of New York, Buffalo, NY, USA
    Clin Infect Dis 49:1729-32. 2009
    ..Bisphosphonates may not be the primary cause. Actinomyces are an underrecognized agent in pathogenesis, and timely actinomycosis-specific treatment may improve outcome.
  28. ncbi In vitro Actinomyces israelii biofilm development on IUD copper surfaces
    Monica Carrillo
    Laboratory of Industrial Microbiology and Biofilms, Engineering Institute, Universidad Autonoma de Baja California, Mexicali, Baja California, Mexico
    Contraception 81:261-4. 2010
    ..The predominant causative agent of human actinomycosis is Actinomyces israelii, which has been found on copper IUDs retrieved from patients.
  29. ncbi Characterization of the Actinomyces naeslundii ureolysis and its role in bacterial aciduricity and capacity to modulate pH homeostasis
    Yaling Liu
    Key Laboratory for Oral Biomedical Engineering Ministry of Education, Chengdu City, PR China
    Microbiol Res 161:304-10. 2006
    ..b>Actinomyces naeslundii is an important ureolytic organism in the oral cavity...
  30. ncbi Reclassification of Actinomyces humiferus (Gledhill and Casida) as Cellulomonas humilata nom. corrig., comb. nov
    M D Collins
    Department of Food Science and Technology, University of Reading, UK
    Int J Syst Evol Microbiol 50:661-3. 2000
    The placement of Actinomyces humiferus within the genus Actinomyces has always been controversial. A humiferus differs from typical members of the genus both phenotypically and in possessing a relatively high DNA G + C content...
  31. pmc Characterization of Actinomyces isolates from infected root canals of teeth: description of Actinomyces radicidentis sp. nov
    M D Collins
    Department of Food Science and Technology, University of Reading, Reading RG6 6AP, United Kingdom
    J Clin Microbiol 38:3399-403. 2000
    Two strains of a previously undescribed Actinomyces-like bacterium were recovered in pure culture from infected root canals of teeth...
  32. pmc Disseminated coinfection with Actinomyces graevenitzii and Mycobacterium tuberculosis: case report and review of the literature
    Andreas Tietz
    Section of Infectious Diseases, LSU Health Sciences Center, 1542 Tulane Ave, New Orleans, LA 70112 2822, USA
    J Clin Microbiol 43:3017-22. 2005
    We report the first case of disseminated infection with both Actinomyces graevenitzii and Mycobacterium tuberculosis and review the medical literature. Concomitant actinomycosis and tuberculosis is very rare...
  33. pmc Amended description of the genes for synthesis of Actinomyces naeslundii T14V type 1 fimbriae and associated adhesin
    Ping Chen
    Microbiology Branch, U S Army Dental and Trauma Research Detachment, 310B B Street, Great Lakes, IL 60088, USA
    Infect Immun 75:4181-5. 2007
    The type 1 fimbriae of Actinomyces naeslundii T14V mediate adhesion of this gram-positive species to the tooth surface...
  34. ncbi The isolation of Actinomyces naeslundii from sound root surfaces and root carious lesions
    S R Brailsford
    Joint Microbiology Research Unit, King s College School of Medicine and Dentistry, Dental School, London, UK
    Caries Res 32:100-6. 1998
    The isolation of Actinomyces naeslundii from sound, exposed root surfaces (n = 56) and soft and leathery root carious lesions (n = 71) was investigated. Root carious lesions were sampled after the removal of overlying plaque...
  35. pmc Fusobacterium nucleatum ATCC 10953 requires Actinomyces naeslundii ATCC 43146 for growth on saliva in a three-species community that includes Streptococcus oralis 34
    Saravanan Periasamy
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 310, Bethesda, MD 20892 4350, USA
    Appl Environ Microbiol 75:3250-7. 2009
    ..in dental plaque, but they become prevalent after the initial commensal colonizers, such as streptococci and actinomyces, have established communities...
  36. ncbi Identification of early microbial colonizers in human dental biofilm
    J Li
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
    J Appl Microbiol 97:1311-8. 2004
    ..To elucidate the first colonizers within in vivo dental biofilm and to establish potential population shifts that occur during the early phases of biofilm formation...
  37. pmc Human salivary acidic proline-rich proteins and statherin promote the attachment of Actinomyces viscosus LY7 to apatitic surfaces
    R J Gibbons
    Department of Microbiology, Forsyth Dental Center, Boston, Massachusetts 02115
    Infect Immun 56:439-45. 1988
    b>Actinomyces viscosus LY7 cells adsorbed in high numbers to experimental pellicles formed on hydroxyapatite (HA) from human parotid or submandibular saliva but not to pellicles prepared from human plasma or serum...
  38. pmc Role of hydrogen peroxide in competition and cooperation between Streptococcus gordonii and Actinomyces naeslundii
    Nicholas S Jakubovics
    School of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK
    FEMS Microbiol Ecol 66:637-44. 2008
    ..Streptococci do not produce catalase yet tolerate H(2)O(2). We recently demonstrated that coaggregation with Actinomyces naeslundii stabilizes arginine biosynthesis in S. gordonii...
  39. ncbi Actinomyces species, streptococci, and Enterococcus faecalis in primary root canal infections
    Jose F Siqueira
    Oral Microbiology Laboratory, Institute of Microbiology, Federal University of Rio de Janeiro, RJ, Brazil
    J Endod 28:168-72. 2002
    The purpose of this study was to evaluate the prevalence of Actinomyces species, streptococci, and Enterococcus faecalis in primary root canal infections by using a molecular genetic method...
  40. pmc Isolation and expression of the lysis genes of Actinomyces naeslundii phage Av-1
    Allan L Delisle
    Department of Biomedical Sciences, School of Dentistry, University of Maryland, Baltimore, Baltimore, MD 21201, USA
    Appl Environ Microbiol 72:1110-7. 2006
    Like most gram-positive oral bacteria, Actinomyces naeslundii is resistant to salivary lysozyme and to most other lytic enzymes...
  41. ncbi Genotypic diversity of oral Actinomyces naeslundii genospecies 1 and 2 in caries-active preschool children
    G Tang
    Oral Bio Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong
    Oral Microbiol Immunol 19:371-8. 2004
    A total of 991 isolates of Actinomyces naeslundii were obtained from sound approximal tooth sites in either caries-active (n = 35) or caries-free (n = 20) preschool children...
  42. pmc Evidence for recombination between a sialidase (nanH) of Actinomyces naeslundii and Actinomyces oris, previously named 'Actinomyces naeslundii genospecies 1 and 2'
    Thuy Do
    King s College, School of Medicine and Dentistry, London, UK
    FEMS Microbiol Lett 288:156-62. 2008
    b>Actinomyces spp., predominant members of human oral biofilms, may use extracellular sialidase to promote adhesion, deglycosylate immunoglobulins and liberation of nutrients...
  43. pmc Emended description of Actinomyces naeslundii and descriptions of Actinomyces oris sp. nov. and Actinomyces johnsonii sp. nov., previously identified as Actinomyces naeslundii genospecies 1, 2 and WVA 963
    Uta Henssge
    Department of Microbiology, The Henry Wellcome Laboratories for Microbiology and Salivary Research, King s College London Dental Institute, Floor 17, Tower Wing, Great Maze Pond, London SE1 9RT, UK
    Int J Syst Evol Microbiol 59:509-16. 2009
    b>Actinomyces naeslundii is an important early colonizer in the oral biofilm and consists of three genospecies (1, 2 and WVA 963) which cannot be readily differentiated using conventional phenotypic testing or on the basis of 16S rRNA gene ..
  44. pmc Actinomyces in chronic granulomatous disease: an emerging and unanticipated pathogen
    Janine Reichenbach
    Division of Immunology, University Children s Hospital, Zurich, Switzerland
    Clin Infect Dis 49:1703-10. 2009
    ..We report for the first time, to our knowledge, chronic infections with Actinomyces species in 10 patients with CGD...
  45. pmc Sequence analyses of fimbriae subunit FimA proteins on Actinomyces naeslundii genospecies 1 and 2 and Actinomyces odontolyticus with variant carbohydrate binding specificities
    Mirva Drobni
    Department of Odontology Cariology, Umea University, SE 901 87 Umea, Sweden
    BMC Microbiol 6:43. 2006
    b>Actinomyces naeslundii genospecies 1 and 2 express type-2 fimbriae (FimA subunit polymers) with variant Galbeta binding specificities and Actinomyces odontolyticus a sialic acid specificity to colonize different oral surfaces...
  46. ncbi Actinomyces in infected osteoradionecrosis--underestimated?
    Torsten Hansen
    Institute of Pathology, Johannes Gutenberg University Mainz, Langenbeckstr 1, D 55101 Mainz, Germany
    Hum Pathol 37:61-7. 2006
    ..Only very few data exist on Actinomyces in IORN. The study population consisted of 31 patients (7 female, 24 male; median age, 58.3 years)...
  47. pmc Late prosthetic hip joint infection with Actinomyces israelii in an intravenous drug user: case report and literature review
    Rana Zaman
    Division of Infectious Diseases Department of Pathology, Henry Ford Health System, Detroit, Michigan 48202, USA
    J Clin Microbiol 40:4391-2. 2002
    Late infections with Actinomyces israelii have been described for prosthetic hip joints but not in association with intravenous drug use. We present a case of a 43-year-old intravenous drug user who developed A...
  48. pmc Coaggregation-mediated interactions of streptococci and actinomyces detected in initial human dental plaque
    Robert J Palmer
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4350, USA
    J Bacteriol 185:3400-9. 2003
    Streptococci and actinomyces that initiate colonization of the tooth surface frequently coaggregate with each other as well as with other oral bacteria...
  49. ncbi The acid-tolerant microbiota associated with plaque from initial caries and healthy tooth surfaces
    G Svensater
    Department of Oral Biology, Faculty of Odontology, Malmo University, Malmo, Sweden
    Caries Res 37:395-403. 2003
    ....
  50. ncbi Autoinducer 2: a concentration-dependent signal for mutualistic bacterial biofilm growth
    Alexander H Rickard
    National Institutes of Health, NIDCR, Bethesda, MD 20892, USA
    Mol Microbiol 60:1446-56. 2006
    ..We show that mutualistic and abundant biofilm growth in flowing saliva of two human oral commensal bacteria, Actinomyces naeslundii T14V and Streptococcus oralis 34, is dependent upon production of AI-2 by S. oralis 34...
  51. ncbi Effect of calcium glycerophosphate on demineralization in an in vitro biofilm model
    R J M Lynch
    Unilever Oral Care, Bebington, Wirral, UK
    Caries Res 40:142-7. 2006
    ..In dentine, CaGP reduced demineralization significantly only when pulsed before the sucrose. The findings suggest that in vivo, the anti-caries potential of CaGP may be greater if it is applied before a cariogenic challenge...
  52. ncbi In vitro growth, acidogenicity and cariogenicity of predominant human root caries flora
    Song Shen
    Oral Bio Sciences, Faculty of Dentistry, The University of Hong Kong, The Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong SAR, China
    J Dent 32:667-78. 2004
    Streptococcus mutans (Sm), Lactobacillus acidophilus (La) and Actinomyces israelii (Ai) have been associated with root surface caries, which is an increasing problem in elderly Chinese...
  53. ncbi A correlation between age and Actinomyces in the adenotonsillar tissue of children
    P Melgarejo Moreno
    ENT Department, Hospital Santa Maria, Lleida, Spain
    B-ENT 2:95-7. 2006
    The purpose of this study was to investigate the presence of actinomyces in adenotonsillar disease, recurrent infections, or tonsillar hypertrophy in children...
  54. ncbi Isolation of Arcanobacterium (Actinomyces) pyogenes from cases of feline otitis externa and canine cystitis
    S J Billington
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson 85721, USA
    J Vet Diagn Invest 14:159-62. 2002
    ..In both cases, the A. pyogenes isolates were presumptively identified by macrobiochemical tests, and then their identities were confirmed by polymerase chain reaction analysis and 16S rRNA gene sequencing...
  55. ncbi Actinomyces--gathering evidence of human colonization and infection
    Val Hall
    Anaerobe Reference Unit, NPHS Microbiology Cardiff, University Hospital of Wales, Cardiff CF14 4XW, UK
    Anaerobe 14:1-7. 2008
    The roles of the 'classical'Actinomyces spp. as colonizers of oral cavities of man and animals, in development of intra-oral infections and as agents of actinomycosis have been well documented...
  56. pmc Actinomyces neuii subsp. neuii Associated with periprosthetic infection in total hip arthroplasty as causative agent
    Heime Rieber
    Division of Microbiology, MVZ Dr Stein and Colleagues, Mönchengladbach, Germany
    J Clin Microbiol 47:4183-4. 2009
    b>Actinomyces neuii has until now not been described as a pathogen associated with periprosthetic infection in total joint replacement. The case presented here suggests that A. neuii subsp. neuii is a causative pathogen...
  57. pmc Development of amplified 16S ribosomal DNA restriction analysis for identification of Actinomyces species and comparison with pyrolysis-mass spectrometry and conventional biochemical tests
    V Hall
    Anaerobe Reference Unit, Department of Medical Microbiology and Public Health Laboratory, University Hospital of Wales, Cardiff CF4 4XW, United Kingdom
    J Clin Microbiol 37:2255-61. 1999
    Identification of Actinomyces spp. by conventional phenotypic methods is notoriously difficult and unreliable...
  58. pmc Identification of clinical isolates of actinomyces species by amplified 16S ribosomal DNA restriction analysis
    V Hall
    Anaerobe Reference Unit, Department of Medical Microbiology, and Public Health Laboratory, University Hospital of Wales, Cardiff CF14 4XW, United Kingdom
    J Clin Microbiol 39:3555-62. 2001
    ..ARDRA), using enzymes HaeIII and HpaII, was applied to 176 fresh and 299 stored clinical isolates of putative Actinomyces spp...
  59. pmc Regulation of gene expression in a mixed-genus community: stabilized arginine biosynthesis in Streptococcus gordonii by coaggregation with Actinomyces naeslundii
    Nicholas S Jakubovics
    National Institutes of Health NIDCR, Building 30, Room 310, 30 Convent Drive, Bethesda, MD 20892 4350, USA
    J Bacteriol 190:3646-57. 2008
    Interactions involving genetically distinct bacteria, for example, between oral streptococci and actinomyces, are central to dental plaque development...
  60. pmc Exopolysaccharides produced by Streptococcus mutans glucosyltransferases modulate the establishment of microcolonies within multispecies biofilms
    H Koo
    Center for Oral Biology, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Bacteriol 192:3024-32. 2010
    ..S. mutans grown with sucrose in the presence of Streptococcus oralis and Actinomyces naeslundii steadily formed exopolysaccharides, which allowed the initial clustering of bacterial cells and ..
  61. pmc Dual function of a tip fimbrillin of Actinomyces in fimbrial assembly and receptor binding
    Chenggang Wu
    Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, Houston, TX 77030, USA
    J Bacteriol 193:3197-206. 2011
    Interaction of Actinomyces oris with salivary proline-rich proteins (PRPs), which serve as fimbrial receptors, involves type 1 fimbriae...
  62. ncbi Adsorption of salivary and serum proteins, and bacterial adherence on titanium and zirconia ceramic surfaces
    Emilena Maria Castor Xisto Lima
    Department of Prosthodontics and Periodontology, Faculty of Dentistry of Piracicaba, University of Campinas, Piracicaba, SP, Brazil
    Clin Oral Implants Res 19:780-5. 2008
    ..In addition, the protein profiles and bacterial binding properties of pellicles on Ti and ZrO(2) were compared to those formed on hydroxyapatite (HA) surface...
  63. ncbi Actinomyces naeslundii in initial dental biofilm formation
    I Dige
    Department of Dental Pathology, Operative Dentistry and Endodontics, School of Dentistry, Aarhus University, Vennelyst Boulevard 9, 8000 Aarhus C, Denmark
    Microbiology 155:2116-26. 2009
    ..The purpose of this study was to analyse the patterns of colonization and population dynamics of Actinomyces naeslundii compared to streptococci and other bacteria during the initial 48 h of biofilm formation in the oral ..
  64. pmc An Arcanobacterium (Actinomyces) pyogenes mutant deficient in production of the pore-forming cytolysin pyolysin has reduced virulence
    B H Jost
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, Arizona 85721, USA
    Infect Immun 67:1723-8. 1999
    Pyolysin (PLO), the hemolytic exotoxin expressed by Arcanobacterium (Actinomyces) pyogenes, is a member of the thiol-activated cytolysin family of bacterial toxins...
  65. ncbi Non-contact removal of coadhering and non-coadhering bacterial pairs from pellicle surfaces by sonic brushing and de novo adhesion
    H J Busscher
    Department of Biomedical Engineering, University of Groningen, Groningen, The Netherlands
    Eur J Oral Sci 111:459-64. 2003
    ..This study compares removal and de novo adhesion of pairs of coadhering and non-coadhering oral actinomyces and streptococci by sonic brushing on salivary pellicles in a non-contact mode as a function of the distance ..
  66. ncbi Pyruvate phosphate dikinase from a thermophilic actinomyces Microbispora rosea subsp. aerata: purification, characterization and molecular cloning of the gene
    N Eisaki
    Research and Development Division, Kikkoman Corporation, 399 Noda, Noda City, Chiba 278 0037, Japan
    Biochim Biophys Acta 1431:363-73. 1999
    ..Sequence comparison indicates around 50% similarity with other PPDKs and it has all the highly conserved regions of the related enzymes. We expressed the PPDK gene in Escherichia coli and obtained enzymatically active protein...
  67. ncbi Bacterial colonization during de novo plaque formation
    Per Ramberg
    Department of Periodontology, Institute of Odontology, Goteborg University, Sweden
    J Clin Periodontol 30:990-5. 2003
    ..To determine microbial changes that occur during plaque formation in a dentition free of gingival inflammation...
  68. pmc Salivary statherin peptide-binding epitopes of commensal and potentially infectious Actinomyces spp. delineated by a hybrid peptide construct
    Liza Danielsson Niemi
    Department of Odontology Cariology, Umea University, Umea, Sweden
    Infect Immun 72:782-7. 2004
    ..construct (with both a hydroxyapatite-binding portion and a test peptide portion) to map the interaction of Actinomyces species (and Candida albicans) with statherin...
  69. pmc Sortase-catalyzed assembly of distinct heteromeric fimbriae in Actinomyces naeslundii
    Arunima Mishra
    Department of Molecular, Microbial, and Structural Biology, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA
    J Bacteriol 189:3156-65. 2007
    Two types of adhesive fimbriae are expressed by Actinomyces; however, the architecture and the mechanism of assembly of these structures remain poorly understood...
  70. ncbi Direct detection of cell surface interactive forces of sessile, fimbriated and non-fimbriated Actinomyces spp. using atomic force microscopy
    Gaoyan Tang
    Oral Bio Sciences, Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Hong Kong SAR, China
    Arch Oral Biol 49:727-38. 2004
    b>Actinomyces species are predominant early colonizers of the oral cavity and prime mediators of inter-bacterial adhesion and coaggregation. Previous workers have evaluated the adhesion of Actinomyces spp...
  71. ncbi Biofilm growth of Lactobacillus species is promoted by Actinomyces species and Streptococcus mutans
    S K Filoche
    Dental Research Group, Department of Pathology and Molecular Medicine, Wellington School of Medicine, Wellington, New Zealand
    Oral Microbiol Immunol 19:322-6. 2004
    ..of biofilm growth by noncoaggregating Lactobacillus rhamnosus and Lactobacillus plantarum on coculture with Actinomyces naeslundii, Actinomyces gerencseriae, Streptococcus mutans and Veillonella parvula was investigated using an ..
  72. pmc Identification of Actinomyces (Corynebacterium) pyogenes with the API 20 Strep system
    J R Morrison
    Division of Veterinary Medicine, West of Scotland Agricultural College, Veterinary Investigation Centre, Auchincruive, Nr Ayr, United Kingdom
    J Clin Microbiol 26:1865-6. 1988
    A total of 62 strains of Actinomyces pyogenes (previously Corynebacterium pyogenes) were examined by the API 20 Strep system (API System, La Balme Les Grottes, Montalieu-Vercieu, France)...
  73. ncbi Actinomyces europaeus sp. nov., isolated from human clinical specimens
    G Funke
    Department of Medical Microbiology, University of Zurich, Switzerland
    Int J Syst Bacteriol 47:687-92. 1997
    ..Biochemical and chemotaxonomic characterization revealed that the strains belonged to the genus Actinomyces. The phenotypic features of the 10 strains were incompatible with the descriptions of the previously ..
  74. ncbi Pilonidal sinus of the glans penis associated with actinomyces case reports and review of literature
    Shylashree Chikkamuniyappa
    Department of Pathology, University of Texas Health Science Center at San Antonio, TX, USA
    ScientificWorldJournal 4:908-12. 2004
    ..A pilonidal sinus of the penis is a rare entity. The association of a penile pilonidal cyst and Actinomyces is even more uncommon with only three cases reported previously...
  75. ncbi Electroporation-mediated transformation of Arcanobacterium (Actinomyces) pyogenes
    B H Jost
    Department of Veterinary Science and Microbiology, University of Arizona, Tucson 85721, USA
    Plasmid 38:135-40. 1997
    Plasmids derived from pNG2 or RSF1010 were introduced into strains of Arcanobacterium (Actinomyces) pyogenes by electroporation. Electroporation conditions were varied systematically to give a maximum electroporation frequency of 3...
  76. ncbi Salivary gel-forming mucin MUC5B--a nutrient for dental plaque bacteria
    C Wickstrom
    Department of Oral Biology, Faculty of Odontology, Malmo University, Malmo, Sweden
    Oral Microbiol Immunol 23:177-82. 2008
    ....
  77. ncbi Influence of weight on removal of co-adhering bacteria from salivary pellicles by different modes of brushing
    H C van der Mei
    Department of Biomedical Engineering, University of Groningen, Groningen, The Netherlands
    Caries Res 38:85-90. 2004
    This study compared removal of pairs of co-adhering and non-co-adhering oral actinomyces and streptococci from salivary pellicles by manual, rotating/oscillating electric and sonic toothbrushes, applying weights up to 240 g...
  78. pmc Identification of a gene involved in assembly of Actinomyces naeslundii T14V type 2 fimbriae
    M K Yeung
    Department of Pediatric Dentistry, The University of Texas Health Science Center at San Antonio, 78284, USA
    Infect Immun 66:1482-91. 1998
    The nucleotide sequence of the Actinomyces naeslundii T14V type 2 fimbrial structural subunit gene, fimA, and the 3' flanking DNA region was determined...
  79. pmc Effect of the environment on genotypic diversity of Actinomyces naeslundii and Streptococcus oralis in the oral biofilm
    James S Paddick
    Department of Microbiology, Guy s, King s, and St Thomas Dental Institute, King s College London, London, United Kingdom
    Appl Environ Microbiol 69:6475-80. 2003
    The genotypic diversity of Actinomyces naeslundii genospecies 2 (424 isolates) and Streptococcus oralis (446 isolates) strains isolated from two sound approximal sites in all subjects who were either caries active (seven subjects) or ..
  80. ncbi Salivary receptors for the proline-rich protein-binding and lectin-like adhesins of oral actinomyces and streptococci
    S Ruhl
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, Building 30, Room 532, National Institutes of Health, Bethesda, MD 20892, USA
    J Dent Res 83:505-10. 2004
    Colonization of the tooth surface by actinomyces and viridans group streptococci involves the attachment of these bacteria to adsorbed salivary components of the acquired enamel pellicle...
  81. ncbi Metal-dependent repression of siderophore and biofilm formation in Actinomyces naeslundii
    Cas Moelling
    Department of Biology, Ripon College, Ripon, WI, USA
    FEMS Microbiol Lett 275:214-20. 2007
    b>Actinomyces naeslundii is a pioneer of the oral cavity and forms a biofilm on the tooth's surface. Most bacteria require iron for survival and in pathogenic bacteria iron availability regulates virulence gene expression...
  82. ncbi attB site disruption in marine Actinomyces sp. M048 via DNA transformation of a site-specific integration vector
    Yan Hua Hou
    Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, People s Republic of China
    Biotechnol Appl Biochem 50:11-6. 2008
    An efficient conjugation method has been developed for the marine Actinomyces sp. isolate M048 to facilitate the genetic manipulation of the chandrananimycin biosynthesis gene cluster...
  83. pmc Phenotypic identification of Actinomyces and related species isolated from human sources
    N Sarkonen
    Anaerobe Reference Laboratory, National Public Health Institute, Helsinki, Finland
    J Clin Microbiol 39:3955-61. 2001
    ..in chemotaxonomic and molecular biology-based identification methods have clarified the taxonomy of the genus Actinomyces and have led to the recognition of several new Actinomyces and related species...
  84. ncbi The importance of the removal of the intrauterine device in genital colonization by actinomyces
    I Bonacho
    , ,
    Gynecol Obstet Invest 52:119-23. 2001
    ..with antibiotics, it is necessary to remove the intrauterine device (IUD) to eliminate genital colonization by Actinomyces. METHODS: A randomized clinical trial was carried out. Patients were divided into two groups...
  85. pmc Genotypic diversity of clinical Actinomyces species: phenotype, source, and disease correlation among genospecies
    Jill E Clarridge
    Department of Pathology, Baylor College of Medicine, Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center, Houston, Texas, USA
    J Clin Microbiol 40:3442-8. 2002
    We determined the frequency distribution of Actinomyces spp. recovered in a routine clinical laboratory and investigated the clinical significance of accurate identification to the species level...
  86. ncbi Actinomyces naeslundii fimbrial protein Orf977 shows similarity to a streptococcal adhesin
    L Hoflack
    Department of Pediatric Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Oral Microbiol Immunol 16:319-20. 2001
    The nucleotide sequence of the chromosomal DNA, upstream of Actinomyces naeslundii T14V fimbrial gene fimA, was determined...
  87. pmc Mutualism versus independence: strategies of mixed-species oral biofilms in vitro using saliva as the sole nutrient source
    R J Palmer
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 69:5794-804. 2001
    ..coaggregating early colonizers of the tooth surface (Streptococcus gordonii DL1, Streptococcus oralis 34, and Actinomyces naeslundii T14V). Area coverage and cell cluster size measurements showed that attachment of A...
  88. ncbi Sequence of oral bacterial co-adhesion and non-contact brushing
    H C van der Mei
    Department of Biomedical Engineering, University Medical Center Groningen, and University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Dent Res 86:421-5. 2007
    ..A pair of co-adhering streptococci and actinomyces has been used previously to demonstrate non-contact removal by sonic brushing...
  89. pmc Identification of independent Streptococcus gordonii SspA and SspB functions in coaggregation with Actinomyces naeslundii
    P G Egland
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 69:7512-6. 2001
    ..dental plaque formation involve the adherence of early colonizing organisms such as Streptococcus gordonii and Actinomyces naeslundii to the saliva-coated tooth surface and to each other. The S...
  90. ncbi Development of novel oligonucleotide probes for seven Actinomyces species and their utility in supragingival plaque analysis
    G Tang
    Oral Bio Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China
    Oral Dis 9:203-9. 2003
    The traditional, biochemical and enzymatic methods of identifying Actinomyces species are frequently confounded by the similar phenotypic characteristics shared by the different members of this genus...
  91. ncbi The in vivo dynamics of Streptococcus spp., Actinomyces naeslundii, Fusobacterium nucleatum and Veillonella spp. in dental plaque biofilm as analysed by five-colour multiplex fluorescence in situ hybridization
    Ali Al-Ahmad
    Department of Operative Dentistry and Periodontology, Albert Ludwigs University, Freiburg, Germany
    J Med Microbiol 56:681-7. 2007
    ..0006). The decreases of Actinomyces naeslundii content on day 2 and day 7 were significant (P=0.0028). Changes in Veillonella spp...
  92. ncbi Human infections with Actinomyces pyogenes (Corynebacterium pyogenes)
    B Gahrn-Hansen
    Department of Clinical Microbiology, Odense University Hospital, Denmark
    Diagn Microbiol Infect Dis 15:349-54. 1992
    b>Actinomyces pyogenes (Corynebacterium pyogenes), a well-known pathogen in many animals, was isolated from 11 Danish patients since 1968. Bacteriologic characteristics and clinical pictures of the patients are described...
  93. ncbi Severe large bowel obstruction secondary to infection with Actinomyces israelii
    Philipp Valko
    Department of Internal Medicine, Hospital of Lugano, Switzerland
    Scand J Infect Dis 38:231-4. 2006
    ..We report on a 38-y-old female with abdomino-pelvic actinomycosis, characterized by a 10 cm long filiform stenosis of the sigmoid colon and bilateral ovarian abscesses. She developed acute ileus that required emergency surgery...
  94. ncbi [Tuboovaric actinomycosis. A report of a case]
    Yelenys Reyna Mejía Salazar
    División de Ginecología y Obstetricia, Hospital General de Atizapán, Instituto de Salud del Estado de México
    Ginecol Obstet Mex 72:162-5. 2004
    ..Tuboovaric actinomycosis case report...
  95. pmc Different type 1 fimbrial genes and tropisms of commensal and potentially pathogenic Actinomyces spp. with different salivary acidic proline-rich protein and statherin ligand specificities
    T Li
    Department of Odontology/Cariology, , , Sweden
    Infect Immun 69:7224-33. 2001
    b>Actinomyces spp. exhibit type 1 fimbria-mediated adhesion to salivary acidic proline-rich proteins (PRPs) and statherin ligands. Actinomyces spp...
  96. pmc Structural and antigenic types of cell wall polysaccharides from viridans group streptococci with receptors for oral actinomyces and streptococcal lectins
    J O Cisar
    Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 65:5035-41. 1997
    Lectin-mediated interactions between oral viridans group streptococci and actinomyces may play an important role in microbial colonization of the tooth surface...
  97. ncbi Infected osteoradionecrosis of the mandible: follow-up study suggests deterioration in outcome for patients with Actinomyces-positive bone biopsies
    T Hansen
    Institute of Pathology, Johannes Gutenberg University of Mainz, Langenbeckstr 1, D 55101 Mainz, Germany
    Int J Oral Maxillofac Surg 35:1001-4. 2006
    ..Recent studies showed a high prevalence of Actinomyces in IORN...
  98. ncbi Ovarian actinomycosis mimicking malignancy
    Y Atay
    Gynecologic Oncology Clinic, Cukurova University Medical Faculty, Adana, Turkey
    Eur J Gynaecol Oncol 26:663-4. 2005
    ..To emphasize the importance of frozen section diagnosis in the treatment of ovarian carcinoma and to remind physicians that it may mimic ovarian carcinoma and occur in women without intrauterine contraceptive devices (IUDs)...
  99. ncbi Actinomycotic infection of the abdominal wall mimicking a malignant neoplasm
    Fia Yi
    Department of Surgery, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Surg Infect (Larchmt) 9:85-9. 2008
    b>Actinomyces infections can create diagnostic dilemmas and be mistaken for malignant tumors.
  100. ncbi Cervical actinomycosis with spinal cord compression. Case report and literature review
    Guo Ping Xu
    Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China
    Chemotherapy 54:63-6. 2008
    ..The diagnosis must be made promptly because delayed treatment can result in irreversible neurologic damage or death. Timely and long-term antibacterial therapy is essential for the complete recovery of the patient with actinomycosis...
  101. ncbi Actinomyces meyeri isolation from synovial fluid of a patient with metastatic squamous cell lung carcinoma
    Emel S Cetin
    Department of Microbiology and Clinical Microbiology, Suleyman Demirel University, Isparta, Turkey
    Saudi Med J 26:1997-9. 2005

Research Grants62

  1. Coenzyme F420-dependent enzymes in mycobacteria
    Biswarup Mukhopadhyay; Fiscal Year: 2013
    ..Mycobacterium leprae, which cause tuberculosis (TB) and leprosy, respectively, and Streptomyces, Nocardia, and Actinomyces that produce numerous antibiotics, anticancer agents, and immunomodulators...
  2. The effect of inter-species interactions on the virulence of Streptococcus mutans
    Bing yan Wang; Fiscal Year: 2009
    ..the experimental focus of this proposal will be to determine the effects of other early colonizers such as Actinomyces naeslundii and later anaerobic colonizers such as Porphyromonas gingivalis on quorum-sensing in S...
  3. Inhibition of oral bacterial biofilm formation using natural products-inspired or
    NATHANIEL CHARLES CADY; Fiscal Year: 2012
    ..study will focus on three ecologically relevant organisms: Streptococcus mutans, Streptococcus sanguinis and Actinomyces naeslundii. S. mutans has been implicated in oral disease and caries formation, while S. sanguinis and A...
  4. Molecular Assembly on the Cell Surface of Actinomyces
    Hung Ton-That; Fiscal Year: 2013
    ..b>Actinomyces is a key early colonizer that plays a prominent role in biofilm development by virtue of its ability to ..
  5. Oxidative protein folding of pilins and virulence in Gram-positive bacteria
    MELISSA ELIZABETH ROBINSON; Fiscal Year: 2013
    ..Recently structural studies of FimA and SpaA, the pilus shaft proteins expressed by the Actinobacteria Actinomyces oris and Corynebacterium diphtheriae, respectively, revealed insight into this biological problem...
  6. CLONING AND PURIFICATION OF A VEILLONELLA ADHESIN
    Christopher Hughes; Fiscal Year: 1993
    ..Veillonella, Prevotella, Actinomyces and Streptococcus utilize similar mechanisms to adhere to common streptococcal coaggregation partners...
  7. IN SITU ANALYSIS OF HUMAN PLAQUE FORMATION
    Greg Germaine; Fiscal Year: 1991
    ..specific at the genus, species and, in some cases, serotype levels will be prepared against oral Streptococcus, Actinomyces, Veillonella, Lactobacillus, Neisseria, Hemophilus, Bacteroides, Fusobacterium, Capnocytophaga, Actinobacillus ..
  8. STRUCTURE OF THE RECEPTORS FOR ORAL BACTERIAL ADHESINS
    C Bush; Fiscal Year: 1991
    ..sanguis whose capsular polysaccharides are know to act as the receptors for the fimbrial lectins of Actinomyces species...
  9. PERIODONTAL DISEASES: B CELLS ACTIVATED BY MITOGENS
    JAMES CLAGETT; Fiscal Year: 1980
    ..suggest that nonspecific polyclonal activation of host B-cells by substances from the dental plaque bacterium, Actinomyces viscosus (AVIS) may play an important role in the recruitment, maturation and differentiation of B-cells into ..
  10. DEVELOPMENT OF A MARINE ANTI-PLAQUE COMPOUND
    TREVOR CASTOR; Fiscal Year: 2000
    ..marine microorganisms were screened for anti-microbial activity against - Haemophilus actinomycetemcomitans, Actinomyces viscosus, and Streptococcus mutans...
  11. GENETICS OF ANTIBODIES TO PERIODONTAL PATHOGENS
    JEROME HABER; Fiscal Year: 1990
    ..The proposed project, which is based on ongoing studies of genetic control of the serum antibody responses to Actinomyces viscosus, is a detailed study of genetic control of the specificity of serum antibodies to purified type 1 ..
  12. Analyses of Host-Biofilm Interactions: A Novel Polymicrobial Model
    Karen Novak; Fiscal Year: 2009
    ..This initial colonization by streptococci is followed by increasing proportions of Actinomyces, Veillonella, and Fusobacterium spp...
  13. ORAL ECOLOGY OF PROSTHETIC SURFACES
    Mira Edgerton; Fiscal Year: 1991
    ..The potential role of salivary mucins and secretory IgA in the adherence of Streptococcus and Actinomyces species to a denture surface will be defined by determination of binding affinities of these microorganisms to ..
  14. BACTERIAL ADHESION TO DENTIN IN ROOT SURFACE CARIES
    LECH SWITALSKI; Fiscal Year: 1993
    ..however some bacteria are isolated from root caries lesions most often: Lactobacilli, Streptococcus mutans and Actinomyces. The mechanisms which localize these and other bacteria to the root surface are unknown and therefore effective ..
  15. TERTIARY STRUCTURES OF SALIVARY PROTEINS
    MARK LAMKIN; Fiscal Year: 1993
    ..study using acidic proline-rich proteins which, only when adsorbed onto hydroxyapatite, have been shown to bind Actinomyces viscosus, Bacteroides gingivalis, and Streptococcus mutans...
  16. CELLULAR IMMUNE RESPONSES TO ORAL BACTERIAL ANTIGENS
    PRISCILLA CHEN; Fiscal Year: 1980
    ..Extracts are being prepared from Actinomyces viscosus and Bacteroides asaccharolyticus...
  17. LYSIS OF CARIOGENIC BACTERIA BY PHAGE-ENCODED ENZYMES
    ALLAN DELISLE; Fiscal Year: 2002
    ..cell wall-hydrolyzing enzymes encoded in the genomes of phages specific for Streptococcus mutans and Actinomyces naeslundii as new therapeutic treatments for dental caries. S...
  18. Gene Regulation of Fimbriae in Actinomyces naeslundii
    SOPHIA PINA; Fiscal Year: 2004
    b>Actinomyces naeslundii is a resident of the normal oral flora, however, it also has the potential to cause disease, namely root caries and periodontitis (3, 4). Colonization by A...
  19. POLYPHENOL OXIDASES AS ANTIADHESINS
    RONALD DOYLE; Fiscal Year: 1999
    ..in which PPO will prevent coaggregation reactions between selected coaggregating pairs, including streptococci, actinomyces and gram-negative periodontopathogens. 3...
  20. MECHANISM OF A. NAESLUNDII ADHESION TO BUCCAL EPITHELIUM
    JEGDISH BABU; Fiscal Year: 1991
    ..studies logically, the experiments proposed in this application are focused on the mechanisms of adhesion of Actinomyces naeslundii to the buccal epithelial cells, and the role of salivary macromolecules play in mediating these ..
  21. MOLECULAR ANALYSIS OF ACTINOMYCES FIMBRIAE
    STEPHEN MATTINGLY; Fiscal Year: 2002
    DESCRIPTION (Adapted from the Applicant's Abstract): Actinomyces spp. Are one of the primary colonizers of the oral cavity and persist from infancy to adulthood...
  22. SALIVA/GLUCOSYLTRANSFERASE INTERACTIONS ON SURFACES
    William Bowen; Fiscal Year: 2002
    ..Such information may make it possible to design molecules which will compete with S. mutans and certain actinomyces for sites on glucan-coated pellicle.
  23. SALIVA-GLUCOSYLTRANSFERASE INTERACTIONS ON SURFACES
    William Bowen; Fiscal Year: 1993
    ..Such information may make it possible to design molecules which will compete with S. mutans and certain actinomyces for sites on glucan-coated pellicle.
  24. MECHANISMS OF VIRULENCE OF ORAL PERIODONTOPATHOGENS
    DALE BIRDSELL; Fiscal Year: 1980
    ..Oral Actinomyces spp. have been strongly implicated in the etiology of gingivitis and, possibly, periodontitis...
  25. THE WHOLE GENOME SEQUENCE OF ACTINOMYCES NAESLUNDI
    Timothy Read; Fiscal Year: 2001
    ..The goal of this two year project is to determine the sequence of the chromosome of the human oral bacterium Actinomyces naeslundii. A. naeslundii is the most prominent actinomyces sp...
  26. Three Periodontal Therapies in Current & Non-Smokers
    Anne Haffajee; Fiscal Year: 2007
    ..The proposed investigation should provide a model to examine methods that could be useful in treating compromised patients whether compromised by harmful habits such as smoking, systemic disease, or genetic background. ..
  27. Identification of Uncultivated and Unrecognized Pathogens of Periodontitis
    ANNE DENISE HAFFAJEE; Fiscal Year: 2010
    ..The identification of such pathogens should, over time, lead to better diagnosis of disease, optimal treatment strategies for the individual patient, new therapeutic approaches and carefully targeted approaches to prevention. ..
  28. MICROBIAL ASSOCIATIONS IN PERIODONTAL HEALTH AND DISEASE
    Anne Haffajee; Fiscal Year: 2006
    ..These data will provide a basis for understanding microbial community structure, ecological relationships and define desired microbiological end-point of therapy. ..
  29. EFFECT OF ANTIBIOTICS ON ORAL BIOFILMS IN VIVO
    Anne Haffajee; Fiscal Year: 2001
    ..abstract_text> ..
  30. New Pathogens for Childhood Caries
    Anne Tanner; Fiscal Year: 2008
    ..As a result, it is expected that many of the negative consequences of this disease will be avoided, with attendant reductions in the costs of dental and related medical care. ..
  31. Oral Immunology/Microbiology Research Group Annual Mtg
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  32. INITIAL LESION OF ADULT PERIODONTITIS
    Anne Tanner; Fiscal Year: 2002
    ....
  33. Microbial Markers for Periodontal Disease in Children
    Daniel Fine; Fiscal Year: 2005
    ....
  34. Oral Immunology/Microbiology Annual Meeting
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  35. Attachment of Oral Actinobacillus to Epithelium
    Daniel Fine; Fiscal Year: 2008
    ..The longterm goal of this application is to use this information to identify targets for therapeutic agents that can interfere with attachment of Aa to oral tissues and thus prevent colonization leading to LAP. [unreadable] [unreadable]..
  36. BIOSYNTHESIS APPROACH TO NOVEL BIOACTIVE AMINOCYCLITOLS
    Taifo Mahmud; Fiscal Year: 2010
    ..The knowledge and methods that arise from these studies will also be widely applicable to expanding the chemical diversity of other families of bioactive natural products. ..
  37. Obesity, Oral Contraception and Ovarian Suppression
    Carolyn Westhoff; Fiscal Year: 2007
    ..This study will have very good power to detect clinically important differences. Results could directly and immediately affect contraceptive practice. ..
  38. Photodynamic Therapy for Endodontic Disinfection
    NIKOLAOS SOUKOS; Fiscal Year: 2009
    ..Photodynamic therapy may be an adjunctive procedure to kill residual root canal bacteria after their sensitization with a photoactive drug and their subsequent exposure to light. ..
  39. Design of peptide entry inhibitors and delivery systems to target emerging henipa
    Anne Moscona; Fiscal Year: 2010
    ..abstract_text> ..
  40. Design of peptide entry inhibitors and delivery systems to target emerging henipa
    Anne Moscona; Fiscal Year: 2008
    ..abstract_text> ..
  41. Modulation of Dendritic Cell Function by Cytomegalovirus
    JATIN VYAS; Fiscal Year: 2008
    ..The proposed program will allow the candidate to obtain the skills, knowledge and experience to become an independent investigator. ..
  42. Quantification of Host Markers in GCF Using CBIB
    Ricardo Teles; Fiscal Year: 2007
    ..Moreover, this methodology is at the forefront of new approaches in proteomics, and carries enormous promise for translational applications in the near future. [unreadable] [unreadable]..
  43. EXPERIMENTAL PATHOLOGY SHARED RESOURCE LABORATORY
    Laura Lamps; Fiscal Year: 2003
    ..abstract_text> ..
  44. Oral Streptococci, Cytokines, PAF-r in EC Coagulation
    Chin Lo Hahn; Fiscal Year: 2003
    ..We also hope to provide an insight regarding streptococcal invasion into EC and offer an alternative model for the initial formation of vegetation. ..
  45. ORAL MUCOSA MICROBIOTA IN HEALTH, CANCER & MUCOSITIS
    Donna Mager; Fiscal Year: 2004
    ..Detection on unusual microbial shifts in mucositis might suggest possible routes to minimizing this condition. ..
  46. Lysine decarboxylase in periodontitis patients
    Martin Levine; Fiscal Year: 2004
    ..abstract_text> ..
  47. RCT of a Novel Oral Contraceptive Initiation Method
    Carolyn Westhoff; Fiscal Year: 2004
    ..We will also assess dual method use for STD prevention in the study to adoption of and adherence to oral contraceptives. We will also assess dual method use for STD prevention in the study population. ..
  48. Photosensitization of Oral Bacteria
    NIKOLAOS SOUKOS; Fiscal Year: 2004
    ..In the same biofilm models the photodynamic effects of the PS will be established and PW-enhanced photosensitization of periodontopathogens by the PS will be evaluated. ..
  49. Molecular Epidemiological Approach to Determine S. mutans
    Yihong Li; Fiscal Year: 2005
    ..Application of the new molecular tools will have a substantial impact on improving the oral health of children. ..
  50. Cell Tracking and imaging gene expression in the brain
    Harish Poptani; Fiscal Year: 2006
    ..Correlation of MRI and PET images will be performed in vivo and in vitro using anatomical markers and with immunohistochemical staining for the beta-galactosidase activity. ..
  51. Periodontal Disease and Prematurity
    Ananda Dasanayake; Fiscal Year: 2006
    ..The collective expertise of the investigative team and the excellent clinical and research facilities are additional strengths. ..
  52. Gene Expression in Chronic and Aggressive Periodontitis
    Panos Papapanou; Fiscal Year: 2006
    ..Ultimately, a pathobiology-based classification of periodontitis will facilitate correct diagnosis and targeted, efficient therapeutic prevention and intervention strategies. [unreadable] [unreadable]..
  53. MR Spectroscropy and Imaging in Head and Neck Tumors
    Harish Poptani; Fiscal Year: 2007
    ..abstract_text> ..
  54. SALIARY IMMUNE RESPONSE TO COMMENSAL ORAL BACTERIA
    Michael Cole; Fiscal Year: 2002
    ..This work should provide important information concerning colonization of the human mouth by pioneer bacteria and may demonstrate the ability of SIgA to influence the presence of specific bacterial clones. ..