gram positive bacteria


Summary: Bacteria which retain the crystal violet stain when treated by Gram's method.

Top Publications

  1. pmc Purification and characterization of a novel class IIa bacteriocin, piscicocin CS526, from surimi-associated Carnobacterium piscicola CS526
    Koji Yamazaki
    Laboratory of Marine Food Science, Graduate School of Fisheries Sciences, Hokkaido University, 3 1 1 Minato, Hakodate 041 8611, Japan
    Appl Environ Microbiol 71:554-7. 2005
  2. ncbi Ribosomally synthesized antibacterial peptides in Gram positive bacteria
    Dzung B Diep
    Department of Chemistry and Biotechnology, Agricultural University of Norway, As
    Curr Drug Targets 3:107-22. 2002
  3. ncbi Assembly of pili in Gram-positive bacteria
    Hung Ton-That
    Committee on Microbiology, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA
    Trends Microbiol 12:228-34. 2004
  4. ncbi Biofilm formation as microbial development
    Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Annu Rev Microbiol 54:49-79. 2000
  5. ncbi Dual activation of the Drosophila toll pathway by two pattern recognition receptors
    Vanessa Gobert
    Unité Propre de Recherche 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F67084 Strasbourg Cedex, France
    Science 302:2126-30. 2003
  6. pmc Investigation of candidate division TM7, a recently recognized major lineage of the domain Bacteria with no known pure-culture representatives
    P Hugenholtz
    Advanced Wastewater Management Centre, Department of Microbiology and Parasitology, The University of Queensland, Brisbane 4072, Australia
    Appl Environ Microbiol 67:411-9. 2001
  7. ncbi Distribution of multi-resistant Gram-negative versus Gram-positive bacteria in the hospital inanimate environment
    S W Lemmen
    Department of Infection Control, University Hospital Aachen, 52057 Aachen, Germany
    J Hosp Infect 56:191-7. 2004
  8. ncbi Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall
    S K Mazmanian
    Department of Microbiology and Immunology, UCLA School of Medicine, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Science 285:760-3. 1999
  9. ncbi Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus
    Per H Mygind
    Novozymes A S, 2880 Bagsvaerd, Denmark
    Nature 437:975-80. 2005
  10. ncbi Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria
    M Kleerebezem
    Department of Biophysical Chemistry, NIZO, Ede, The Netherlands
    Mol Microbiol 24:895-904. 1997

Detail Information

Publications292 found, 100 shown here

  1. pmc Purification and characterization of a novel class IIa bacteriocin, piscicocin CS526, from surimi-associated Carnobacterium piscicola CS526
    Koji Yamazaki
    Laboratory of Marine Food Science, Graduate School of Fisheries Sciences, Hokkaido University, 3 1 1 Minato, Hakodate 041 8611, Japan
    Appl Environ Microbiol 71:554-7. 2005
    ..The molecular mass of piscicocin CS526, which had a bactericidal mode of action, was approximately 4,430 Da...
  2. ncbi Ribosomally synthesized antibacterial peptides in Gram positive bacteria
    Dzung B Diep
    Department of Chemistry and Biotechnology, Agricultural University of Norway, As
    Curr Drug Targets 3:107-22. 2002
  3. ncbi Assembly of pili in Gram-positive bacteria
    Hung Ton-That
    Committee on Microbiology, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA
    Trends Microbiol 12:228-34. 2004
  4. ncbi Biofilm formation as microbial development
    Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Annu Rev Microbiol 54:49-79. 2000
    ..The results reviewed in this article indicate that the formation of biofilms serves as a new model system for the study of microbial development...
  5. ncbi Dual activation of the Drosophila toll pathway by two pattern recognition receptors
    Vanessa Gobert
    Unité Propre de Recherche 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F67084 Strasbourg Cedex, France
    Science 302:2126-30. 2003
    ..The potential for a combination of distinct proteins to mediate detection of infectious nonself in the fly will refine the concept of pattern recognition in insects...
  6. pmc Investigation of candidate division TM7, a recently recognized major lineage of the domain Bacteria with no known pure-culture representatives
    P Hugenholtz
    Advanced Wastewater Management Centre, Department of Microbiology and Parasitology, The University of Queensland, Brisbane 4072, Australia
    Appl Environ Microbiol 67:411-9. 2001
    ..A highly atypical base substitution (Escherichia coli position 912; C to U) for bacterial 16S rRNAs was present in almost all TM7 sequences, suggesting that TM7 bacteria, like Archaea, may be streptomycin resistant at the ribosome level...
  7. ncbi Distribution of multi-resistant Gram-negative versus Gram-positive bacteria in the hospital inanimate environment
    S W Lemmen
    Department of Infection Control, University Hospital Aachen, 52057 Aachen, Germany
    J Hosp Infect 56:191-7. 2004
    ..This benefits not only the patients, but also the hospital by removing some of the strain placed on already over-stretched resources...
  8. ncbi Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall
    S K Mazmanian
    Department of Microbiology and Immunology, UCLA School of Medicine, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Science 285:760-3. 1999
    ..The protein specified by srtA, sortase, may be a useful target for the development of new antimicrobial drugs...
  9. ncbi Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus
    Per H Mygind
    Novozymes A S, 2880 Bagsvaerd, Denmark
    Nature 437:975-80. 2005
    ..These findings identify fungi as a novel source of antimicrobial defensins, and show the therapeutic potential of plectasin. They also suggest that the defensins of insects, molluscs and fungi arose from a common ancestral gene...
  10. ncbi Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria
    M Kleerebezem
    Department of Biophysical Chemistry, NIZO, Ede, The Netherlands
    Mol Microbiol 24:895-904. 1997
    ..Moreover, genetic linkage of the common elements involved results in autoregulation of peptide-pheromone production...
  11. ncbi High-throughput PCR screening of genes for three-component regulatory system putatively involved in quorum sensing from low-G + C gram-positive bacteria
    Jiro Nakayama
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biosci Biotechnol Biochem 67:480-9. 2003
    ..These results indicated the usefulness of this high-throughput gene screening and suggested that the three-component regulatory gene cassette are widely present...
  12. ncbi Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
    T Michel
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 15 rue Rene Descartes, 67084 Strasbourg Cedex, France
    Nature 414:756-9. 2001
    ..Interestingly, seml does not affect Toll activation by fungal infection, indicating the existence of a distinct recognition system for fungi to activate the Toll pathway...
  13. ncbi Peptide pheromone-dependent regulation of antimicrobial peptide production in Gram-positive bacteria: a case of multicellular behavior
    M Kleerebezem
    Wageningen Centre for Food Sciences, The Netherlands
    Peptides 22:1579-96. 2001
    ..This review focuses on the major advances and current views of the peptide-pheromone dependent regulatory circuits involved in production of antimicrobial peptides in Gram-positive bacteria...
  14. ncbi Bacteremia in children: etiologic agents, focal sites, and risk factors
    L F Nimri
    Department of Applied Biology, Jordan University of Science and Technology, Irbid
    J Trop Pediatr 47:356-60. 2001
    ..Resistance of the isolated pathogens to several commonly used antibiotics was observed. Empirical treatment with antibiotics is recommended only in life-threatening cases...
  15. ncbi Production of piscicolin 126 by Carnobacterium maltaromaticum UAL26 is controlled by temperature and induction peptide concentration
    Lucas J Gursky
    Department of Agricultural, Food, and Nutritional Science, 4 10 Agriculture Forestry Centre, University of Alberta, Edmonton, AB, Canada T6G 2P5
    Arch Microbiol 186:317-25. 2006
    ..This deletion causes a frameshift, resulting in truncation of the PisE transport accessory protein in UAL26...
  16. ncbi Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria
    Greg Elson
    NovImmune SA, Geneva, Switzerland
    Blood 109:1574-83. 2007
    ..This study identifies dominant TLRs involved in responses to whole bacteria. It also validates the concept that host cell activation by bacterial pathogens can be therapeutically reduced by anti-TLR4, -TLR2, and -CD14 mAbs...
  17. pmc Multimodular penicillin-binding proteins: an enigmatic family of orthologs and paralogs
    C Goffin
    Centre d Ingénierie des Protéines, Universite de Liege, Institut de Chimie, B 4000 Sart Tilman Liège, Belgium
    Microbiol Mol Biol Rev 62:1079-93. 1998
    ..Studies of the reaction pathways by using the methods of quantum chemistry suggest that resistance to penicillin is a road of no return...
  18. pmc Antibacterial spectrum of a novel des-fluoro(6) quinolone, BMS-284756
    J C Fung-Tomc
    Department of Microbiology, Bristol Myers Squibb Company, Wallingford, Connecticut 06492, USA
    Antimicrob Agents Chemother 44:3351-6. 2000
    ..These results indicate that with its broad antibacterial spectrum, BMS-284756 should be evaluated clinically for the treatment of community and nosocomial infections...
  19. ncbi Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells
    Hassan Lemjabbar
    Biomedical Sciences Program, Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, California, USA
    Nat Med 8:41-6. 2002
    ..Unlike responses in macrophages, the epithelial-cell response to lipoteichoic acid does not require Toll-like receptor 2 or 4...
  20. pmc Genome-wide detection and analysis of cell wall-bound proteins with LPxTG-like sorting motifs
    Jos Boekhorst
    Center for Molecular and Biomolecular Informatics, Radboud University Nijmegen, The Netherlands
    J Bacteriol 187:4928-34. 2005
  21. pmc Bacterial community structure and location in Stilton cheese
    Danilo Ercolini
    Division of Food Sciences, School of Biosciences, University of Nottingham, Loughborough, Leicestershire LE12 5RD, United Kingdom
    Appl Environ Microbiol 69:3540-8. 2003
  22. ncbi Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria
    Vincent Bischoff
    Institut de Biologie Moleculaire et Cellulaire, CNRS UPR 9022, 15 rue Rene Descartes, Universite Louis Pasteur, 67084 Strasbourg Cedex, France
    Nat Immunol 5:1175-80. 2004
    ..These data indicate that PGRP-SD can function as a receptor for Gram-positive bacteria and shows partial redundancy with the PGRP-SA-GNBP1 complex...
  23. ncbi The antibacterial activity against MRSA strains and other bacteria of a <500Da fraction from maggot excretions/secretions of Lucilia sericata (Diptera: Calliphoridae)
    Alyson Bexfield
    Department of Biological Sciences, SOTEAS, Swansea University, Singleton Park, Swansea, SA2 8PP, UK
    Microbes Infect 10:325-33. 2008
    ..aureus and E. coli. ES<500 also demonstrated bacteriostatic activity against S. aureus, however, bactericidal activity and the induction of a viable but non-culturable state were observed with ES<500-treated E. coli...
  24. pmc Effects on gram-negative and gram-positive bacteria mediated by 5-aminolevulinic Acid and 5-aminolevulinic acid derivatives
    Nicolas Fotinos
    Department of Pharmaceutics and Biopharmaceutics, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 30 Quai Ernest Ansermet, Geneva 1211, Switzerland
    Antimicrob Agents Chemother 52:1366-73. 2008
    ..We observed significant differences in terms of the optimal drug concentration, bactericidal activities, and porphyrin production...
  25. ncbi Clinical gram-positive sepsis: does it fundamentally differ from gram-negative bacterial sepsis?
    S M Opal
    Brown University School of Medicine, Povidence, RI, USA
    Crit Care Med 27:1608-16. 1999
    ..To review the basic differences between gram-positive and gram-negative sepsis and to assess the effect of these differences on current and future therapeutic strategies for sepsis...
  26. ncbi Emerging bacterial resistance patterns in febrile neutropenic patients: experience at a tertiary care hospital in Pakistan
    M A Khan
    Department of Medicine, The Aga Khan University Hospital, Karachi
    J Pak Med Assoc 54:357-60. 2004
    ..To look at the clinical presentations, spectrum and site of isolation of the organisms, sensitivity patterns of the organisms and the antibiotic prescribing practices for the treatment of febrile neutropenic patients at our hospital...
  27. ncbi The effect of dietary fatty acids on lactic acid bacteria associated with the epithelial mucosa and from faecalia of Arctic charr, Salvelinus alpinus (L.)
    E Ringø
    Department of Arctic Veterinary Medicine, Norwegian College of Veterinary Medicine, Tromsø, Norway
    J Appl Microbiol 85:855-64. 1998
    ..and Leuconostoc mesenteroides present. Seven strains of Carnobacterium spp. were further identified on the basis of 16S rDNA sequence analysis, and all these strains were identified as Carnobacterium piscicola...
  28. pmc Use of pyrosequencing of 16S rRNA fragments to differentiate between bacteria responsible for neonatal sepsis
    Jeanne A Jordan
    Department of Pathology, University of Pittsburgh, Magee Women s Research Institute, 204 Craft Avenue, Pittsburgh, PA 15213, USA
    J Mol Diagn 7:105-10. 2005
    ..Results of DNA sequencing and culture identification were compared. In summary, we were successful at using PCR and pyrosequencing together to accurately differentiate between highly diverse bacterial groups...
  29. ncbi Interfacial charge transfer between CdTe quantum dots and gram negative vs gram positive bacteria
    Eve Dumas
    Department of Biomedical Engineering, McGill University, Montreal, QC, Canada H3A 2B4
    Environ Sci Technol 44:1464-70. 2010
    ..The findings also suggest future avenues of inquiry into electron transfer processes between nanomaterials and bacteria...
  30. ncbi Controlling infection by tuning in and turning down the volume of bacterial small-talk
    Miguel Camara
    School of Pharmaceutical Sciences, University of Nottingham, Nottingham, UK
    Lancet Infect Dis 2:667-76. 2002
    ..As a consequence, this event, now termed quorum sensing, represents a novel therapeutic target offering the opportunity to attenuate virulence, and thus control infection, by blocking cell-to-cell communication...
  31. ncbi Design, synthesis, and antibacterial activities of neomycin-lipid conjugates: polycationic lipids with potent gram-positive activity
    Smritilekha Bera
    Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada
    J Med Chem 51:6160-4. 2008
    ..The MIC of neomycin-C16 (C20) conjugates against methicillin-resistant Staphylococcus aureus (MRSA) is comparable to clinically used antiseptics...
  32. pmc Prophenoloxidase activation is not required for survival to microbial infections in Drosophila
    Vincent Leclerc
    UPR9022 du CNRS, IBMC, 15 rue Descartes, 67084 Strasbourg, France
    EMBO Rep 7:231-5. 2006
    ..This raises the question with regard to the precise function of phenoloxidase activation in defence, if any...
  33. pmc Pili in Gram-positive bacteria: assembly, involvement in colonization and biofilm development
    Anjali Mandlik
    Department of Molecular, Microbial, and Structural Biology, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA
    Trends Microbiol 16:33-40. 2008
    ..Here we review current knowledge of this mechanism and the roles of Gram-positive pili in the colonization of specific host tissues, modulation of host immune responses and the development of bacterial biofilms...
  34. ncbi Pattern searches for the identification of putative lipoprotein genes in Gram-positive bacterial genomes
    Iain C Sutcliffe
    Fleming Building, Institute of Pharmacy, Chemistry and Biomedical Sciences, University of Sunderland, Sunderland SR2 3SD, UK
    Microbiology 148:2065-77. 2002
    ..These data confirm the likely abundance of lipoproteins in Gram-positive bacterial genomes, with at least 25 probable lipoproteins identified in S. pyogenes..
  35. pmc Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry
    Desiree H Fong
    Department of Biochemistry, McGill University, 3775 University Street, Montreal, Quebec H3A 2B4, Canada
    EMBO J 21:2323-31. 2002
    ..These results suggest a potential strategy for drug design aimed at circumventing antibiotic resistance...
  36. ncbi Scavenger cells with gram-positive bacterial lipoteichoic acid infiltrate around the damaged interlobular bile ducts of primary biliary cirrhosis
    K Tsuneyama
    Department of Pathology (II, School of Medicine, Kanazawa University, Japan
    J Hepatol 35:156-63. 2001
    ..Such LTA may be involved in the development and progression of portal tract lesions, particularly bile duct lesions, in PBC...
  37. ncbi Bacteremias: a leading cause of death
    Gonzalo M L Bearman
    Internal Medicine, Epidemiology and Community Medicine, Division of Quality HealthCare, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0019, USA
    Arch Med Res 36:646-59. 2005
    ..Regrettably, despite advances in treatment and intensive care facilities, mortality remains high...
  38. pmc The genome of Heliobacterium modesticaldum, a phototrophic representative of the Firmicutes containing the simplest photosynthetic apparatus
    W Matthew Sattley
    Department of Biology, Washington University, Campus Box 1137, St Louis, Missouri 63130, USA
    J Bacteriol 190:4687-96. 2008
    ..In contrast to the nutritional flexibility of many anoxygenic phototrophs, the complete genome sequence of H. modesticaldum reveals an organism with a notable degree of metabolic specialization and genomic reduction...
  39. ncbi Carnobacterium divergens and Carnobacterium maltaromaticum as spoilers or protective cultures in meat and seafood: phenotypic and genotypic characterization
    Birgit Groth Laursen
    Department of Veterinary Pathobiology, Royal Veterinary and Agricultural University, Grønnegårdsvej 15, 1870 Frederiksberg Copenhagen, Denmark
    Syst Appl Microbiol 28:151-64. 2005
    ..This study serves as a base-line for further investigations on the potential role of species of Carnobacterium in foods where they predominate the spoilage microflora...
  40. pmc Bacterial communication and group behavior
    E Peter Greenberg
    Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Invest 112:1288-90. 2003
    ..This Perspective series discusses the known signaling mechanisms, the roles they play in both chronic Gram-positive and Gram-negative infections, and promising therapeutic avenues of investigation...
  41. ncbi Marine actinomycetes related to the "Salinospora" group from the Great Barrier Reef sponge Pseudoceratina clavata
    Tae Kyung Kim
    Department of Microbiology and Parasitology, School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
    Environ Microbiol 7:509-18. 2005
    ..In vitro bioassays of extracts from the isolates for antibiotic activity demonstrated that these actinomycetes have the potential to inhibit other sponge symbionts in vivo, including both Gram-negative and Gram-positive bacteria...
  42. pmc Serum procalcitonin elevation in critically ill patients at the onset of bacteremia caused by either Gram negative or Gram positive bacteria
    Pierre Emmanuel Charles
    Service de Reanimation Medicale, Hopital Le Bocage, C H U de DIJON, France
    BMC Infect Dis 8:38. 2008
    ..However, we still do not know to what extent the magnitude of PCT elevation at the onset of bacteremia varies according to the Gram stain result...
  43. ncbi Bacteremia in patients with hematological malignancies
    Fu Der Wang
    Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Chemotherapy 51:147-53. 2005
    ..The aim of this study was to investigate isolates of bacteremia and their antibiotic susceptibility in patients with hematological malignancies...
  44. ncbi [Analysis of microorganisms isolated from febrile neutropenic children with neoplastic disease]
    Ilona Wojak
    Laboratorium Mikrobiologiczne Wojewódzkiego, Szpitala Dzieciecego w Bydgoszczy
    Med Dosw Mikrobiol 56:411-9. 2004
    ..faecium, S. haemolyticus. All strains Staphylococcus spp. were sensitive to vancomycin. There have not been found Enterococcus spp. resistant to glycopeptides. Most active against Gram-positive rods were carbapenems and aminoglycosides...
  45. ncbi Shelf life and safety aspects of chilled cooked and peeled shrimps (Pandalus borealis) in modified atmosphere packaging
    O Mejlholm
    Department of Seafood Research, Danish Institute for Fisheries Research DIFRES, Lyngby, Denmark
    J Appl Microbiol 99:66-76. 2005
    ..To evaluate the growth of Listeria monocytogenes and shelf life of cooked and peeled shrimps in modified atmosphere packaging (MAP)...
  46. ncbi Chromosomal replicases as asymmetric dimers: studies of subunit arrangement and functional consequences
    Charles S McHenry
    Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Mol Microbiol 49:1157-65. 2003
    ..For example, Pol e and Pol delta may function as distinct leading and lagging strand polymerases in eukaryotes, and PolC and DnaE may function as distinct leading and lagging strand polymerases in low GC content Gram-positive bacteria...
  47. ncbi Essential oils: their antibacterial properties and potential applications in foods--a review
    Sara Burt
    Department of Public Health and Food Safety, Faculty of Veterinary Medicine, University of Utrecht, P O Box 80175, 3508 TD Utrecht, The Netherlands
    Int J Food Microbiol 94:223-53. 2004
    ..Some EO components are legally registered flavourings in the EU and the USA. Undesirable organoleptic effects can be limited by careful selection of EOs according to the type of food...
  48. ncbi The Drosophila immune system detects bacteria through specific peptidoglycan recognition
    François Leulier
    Centre de Génétique Moléculaire du CNRS, F 91198 Gif sur Yvette, France
    Nat Immunol 4:478-84. 2003
    ..Thus, the ability of Drosophila to discriminate between Gram-positive and Gram-negative bacteria relies on the recognition of specific forms of peptidoglycan...
  49. ncbi Substrate analogues to study cell-wall biosynthesis and its inhibition
    Kristi Lazar
    Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA
    Curr Opin Chem Biol 6:786-93. 2002
    ..These intermediates also enable studies to probe the mechanism of action of a variety of substrate-binding antibiotics...
  50. ncbi Protein sorting to the cell wall envelope of Gram-positive bacteria
    Hung Ton-That
    Committee on Microbiology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Biochim Biophys Acta 1694:269-78. 2004
  51. pmc Real-time PCR for detection and differentiation of gram-positive and gram-negative bacteria
    Sven Klaschik
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany
    J Clin Microbiol 40:4304-7. 2002
    ..All tested bacteria were identified correctly, and none gave a false-positive signal with the opposite Gram probe...
  52. ncbi Gram-positive DsbE proteins function differently from Gram-negative DsbE homologs. A structure to function analysis of DsbE from Mycobacterium tuberculosis
    Celia W Goulding
    Howard Hughes Medical Institute and UCLA Department of Energy Institute of Genomics and Proteomics, Los Angeles, California 90095 1570
    J Biol Chem 279:3516-24. 2004
    ..Structural and biochemical analysis implies that Mtb DsbE functions differently from Gram-negative DsbE homologs, and we discuss its possible functional role in the bacterium...
  53. ncbi Antimicrobial activity of some medicinal plants of the island Soqotra
    Ramzi A A Mothana
    Department of Pharmacognosy, Faculty of Pharmacy, Sana a University, PO Box 33039, Sana a, Yemen
    J Ethnopharmacol 96:177-81. 2005
    ..Only the methanolic extract of Buxus hildebrandtii displayed significant antifungal activity...
  54. ncbi Comparative activity of meropenem in US medical centers (2007): initiating the 2nd decade of MYSTIC program surveillance
    Ronald N Jones
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 61:203-13. 2008
  55. ncbi Improved photoinactivation of gram-negative and gram-positive methicillin-resistant bacterial strains using a new near-infrared absorbing meso-tetrahydroporphyrin: a comparative study with a chlorine e6 photosensitizer photolon
    S Schastak
    Department of Ophthalmology, Universiy of Leipzig, Leipzig, Germany
    Methods Find Exp Clin Pharmacol 30:129-33. 2008
    ..Results suggest that tetracationic BLC1065 can bind better to both Gram-positive and Gram-negative bacterial cell envelope than the dianionic chlorine BLC1013 resulting in better efficiency of photoinactivation...
  56. ncbi Polycationic photosensitizer conjugates: effects of chain length and Gram classification on the photodynamic inactivation of bacteria
    Michael R Hamblin
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Department of Dermatology, Harvard Medical School, Boston, MA 02114 2698, USA
    J Antimicrob Chemother 49:941-51. 2002
    ..In this report we explore the relationship between the size of the polylysine chain and its effectiveness for mediating the killing of Gram-negative and Gram-positive bacteria...
  57. ncbi Display of proteins on bacteria
    Patrik Samuelson
    Division of Molecular Biotechnology, Department of Biotechnology, SCFAB, Royal Institute of Technology KTH, Roslagstullsbacken 21, SE 10691 Stockholm, Sweden
    J Biotechnol 96:129-54. 2002
    ..This article explains the basic principles of the different bacterial display systems, and discusses current uses and possible future trends of these emerging technologies...
  58. ncbi Meropenem activity against European isolates: report on the MYSTIC (Meropenem Yearly Susceptibility Test Information Collection) 2006 results
    Philip J Turner
    Infection Discovery Department, AstraZenca, Alderley House, Alderley Park, Macclesfield, SK10 4TG Cheshire, UK
    Diagn Microbiol Infect Dis 60:185-92. 2008
    ..The continued need for surveillance studies such as MYSTIC in order that correct clinical decisions concerning antibiotic selection are made is once again demonstrated...
  59. ncbi Surface-enhanced Raman scattering for the rapid discrimination of bacteria
    Roger M Jarvis
    School of Chemistry, The University of Manchester, P O Box 88, Sackville St, Manchester, UK
    Faraday Discuss 132:281-92; discussion 309-19. 2006
    ..In addition, Bacillus species also undergo sporulation, and we demonstrate that SERS peaks that could be attributed to the dipicolinic acid biomarker, could be readily generated from Bacillus spores...
  60. ncbi Identification of a novel two-peptide lantibiotic, haloduracin, produced by the alkaliphile Bacillus halodurans C-125
    Elaine M Lawton
    Department of Microbiology, University College Cork, Cork, Ireland
    FEMS Microbiol Lett 267:64-71. 2007
    ..It is also the first example of a lantibiotic of any kind to be produced by an alkaliphilic species...
  61. ncbi Characterization of the theta-type plasmid pCD3.4 from Carnobacterium divergens, and modulation of its host range by RepA mutation
    Marco J van Belkum
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
    Microbiology 152:171-8. 2006
    ..The mutation was located in the C-terminal region of the RepA protein, changing a proline into a serine. This is believed to be the first example of such plasmid-host-range modulation in Gram-positive bacteria...
  62. ncbi Growth control of Listeria monocytogenes on cold-smoked salmon using a competitive lactic acid bacteria flora
    L Nilsson
    Danish Institute for Fisheries Research, Department of Seafood Research, Technical University, Lyngby
    J Food Prot 62:336-42. 1999
    ..monocytogenes that were found on Oxford plates incubated at 25 degrees C reached low maximum cell counts of 10(4) and 2 x 10(3) after 14 and 20 days of storage in mixed culture with C. piscicola A9b and A10a...
  63. ncbi Quorum sensing: the many languages of bacteria
    Nicola C Reading
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    FEMS Microbiol Lett 254:1-11. 2006
    ..Three major quorum-sensing circuits have been described: one used primarily by Gram-negative bacteria, one used primarily by Gram-positive bacteria, and one that has been proposed to be universal...
  64. ncbi Contemporary antimicrobial susceptibility patterns of bacterial pathogens commonly associated with febrile patients with neutropenia
    R N Jones
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    Clin Infect Dis 29:495-502. 1999
    ..e., carbapenems, cefepime, levofloxacin, and trovafloxacin) offer a greater inhibitory potential for empirical therapy among patients with neutropenia and severe infections...
  65. pmc Cold-adapted alanine dehydrogenases from two antarctic bacterial strains: gene cloning, protein characterization, and comparison with mesophilic and thermophilic counterparts
    A Galkin
    Institute for Chemical Research, Kyoto University, Uji, Kyoto Fu 611, Japan
    Appl Environ Microbiol 65:4014-20. 1999
    ..Homology-based structural models of various AlaDHs, including the two psychotropic AlaDHs, were constructed. The thermal instability of SheAlaDH and CarAlaDH may result from relatively low numbers of salt bridges in these proteins...
  66. ncbi Lipoteichoic acid may affect the pathogenesis of bile duct damage in primary biliary cirrhosis
    Ikuko Haruta
    Tokyo Women s Medical University, Department of Medicine and Gastroenterology, Tokyo, Japan
    Autoimmunity 39:129-35. 2006
    ..Gram-positive bacterial DNA was detected recently in gallbladder bile of PBC patients. In the present study, we assessed the possible pathological role of lipoteichoic acid (LTA), the gram-positive bacterial cell wall component, in PBC...
  67. ncbi Inhibition of Listeria monocytogenes by Carnobacterium spp. strains in a simulated cold smoked fish system stored at 4 degrees C
    F Duffes
    ENITIAA, Laboratoire de Microbiologie, Nantes, France
    Int J Food Microbiol 47:33-42. 1999
    ..monocytogenes as early as day 4, whereas C. piscicola SF668 inhibiting effect was observed at day 13. The potential for using such biopreservation treatments on whole smoked salmon is discussed...
  68. ncbi The effect of diet on aerobic bacterial flora associated with intestine of Arctic charr (Salvelinus alpinus L.)
    E Ringø
    Department of Arctic Veterinary Medicine, Norwegian College of Veterinary Medicine, Tromsø, Norway
    J Appl Microbiol 86:22-8. 1999
    ..were isolated from the large intestine of fish fed high carbohydrate. On the contrary, C. divergens-like isolates were found associated with the small and large intestine of fish fed low dietary carbohydrate...
  69. ncbi What are archaebacteria: life's third domain or monoderm prokaryotes related to gram-positive bacteria? A new proposal for the classification of prokaryotic organisms
    R S Gupta
    Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada
    Mol Microbiol 29:695-707. 1998
    ..These observations provide evidence for an alternate view of the evolutionary relationship among living organisms that is different from the currently popular three-domain proposal...
  70. ncbi Clinical spectrum of gram-positive infections in lung transplantation
    M R Gupta
    Department of Internal Medicine, Texas Transplant Center, University of Texas Medical Branch, Galveston, Texas 77555 0772, USA
    Transpl Infect Dis 11:424-31. 2009
    ..This report describes the clinical spectrum of GP infections and their effects on surgical airway complications (SAC) and bronchiolitis obliterans syndrome (BOS) following LT...
  71. ncbi Study of the microbial ecology of cold-smoked salmon during storage at 8 degrees C
    F Leroi
    Laboratoire de Génie Alimentaire, IFREMER, Nantes, France
    Int J Food Microbiol 39:111-21. 1998
    ..Shewanella putrefaciens, Aeromonas spp. and Brachothrix spp. produced strong off-odours while most of the LAB and P. phosphoreum seemed not to be involved in spoilage...
  72. ncbi Evaluation of the role of Carnobacterium piscicola in spoilage of vacuum- and modified-atmosphere-packed cold-smoked salmon stored at 5 degrees C
    C Paludan-Müller
    Danish Institute for Fisheries Research, Department of Seafood Research, Danish Technical University, Lyngby, Denmark
    Int J Food Microbiol 39:155-66. 1998
    ..This was supported by the development of soft texture and sour, rancid and bitter off-flavours at the point of spoilage, irrespective of the length of shelf-life and low or high total counts of LAB and Gram-negative bacteria...
  73. pmc Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity
    Varsha Singh
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:13092-7. 2006
    ..Considering that several coinducers of HSF-1 are currently in clinical trials, this work opens the possibility that activation of HSF-1 could be used to boost immunity to treat infectious diseases and immunodeficiencies...
  74. ncbi Development of matrix lysis for concentration of gram positive bacteria from food and blood
    Peter Rossmanith
    Institute of Milk Hygiene, Milk Technology and Food Science, Department of Veterinary Public Health and Food Science, University of Veterinary Medicine, Veterinarplatz 1, 1210 Vienna, Austria
    J Microbiol Methods 69:504-11. 2007
    ..Using real-time PCR, 7.3 CFU of L. monocytogenes were detected in artificially contaminated ultra-high temperature treated (UHT) milk and raw milk...
  75. pmc Functional characterization of a three-component regulatory system involved in quorum sensing-based regulation of peptide antibiotic production in Carnobacterium maltaromaticum
    Bettina H Rohde
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York City, USA
    BMC Microbiol 6:93. 2006
    ..maltaromaticum LV17B...
  76. pmc The unique 16S rRNA genes of piezophiles reflect both phylogeny and adaptation
    Federico M Lauro
    Center for Marine Biotechnology and Biomedicine, Marine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0202, USA
    Appl Environ Microbiol 73:838-45. 2007
    ..These helix changes are believed to improve ribosome function under deep-sea conditions...
  77. ncbi Insights into heliobacterial photosynthesis and physiology from the genome of Heliobacterium modesticaldum
    W Matthew Sattley
    Department of Biology, MidAmerica Nazarene University, 2030 E College Way, Olathe, KS 66062, USA
    Photosynth Res 104:113-22. 2010
    ..The identities of electron carriers that enable energy conservation by cyclic light-driven electron transfer remain in question...
  78. ncbi An overview of the Meropenem Yearly Susceptibility Test Information Collection (MYSTIC) Program: 1997-2004
    Ronald N Jones
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 53:247-56. 2005
    ..Thus, antipseudomonal carbapenems such as meropenem and imipenem remain an effective treatment option...
  79. ncbi Surface display on gram positive bacteria
    M Hansson
    Department of Biotechnology, Royal Institute of Technology (KTH, Stockholm, S-100 44, Sweden
    Comb Chem High Throughput Screen 4:171-84. 2001
    ..This article explains the basis of Gram-positive bacterial surface display, and discusses current uses and possible future trends of this emerging technology...
  80. pmc Toxic-metabolite-producing bacteria and fungus in an indoor environment
    J Peltola
    Division of Microbiology, Department of Applied Chemistry and Microbiology, University of Helsinki, FIN 00014 University of Helsinki, Finland
    Appl Environ Microbiol 67:3269-74. 2001
    ..The substances from the Streptomyces isolates also swelled the mitochondria. The substances from isolates of Trichoderma harzianum Rifai and Bacillus pumilus damaged the cell membrane barrier function of sperm cells...
  81. ncbi Plantaricin W from Lactobacillus plantarum belongs to a new family of two-peptide lantibiotics
    H Holo
    Laboratory of Microbial Gene Technology, Department of Chemistry and Biotechnology, Agricultural University of Norway, PO Box 5051, N 1432 As, Norway
    Microbiology 147:643-51. 2001
    ..Based on the data a structural model is presented in which each peptide has a central lanthionine and two overlapping thioether bridges close to their C-termini...
  82. ncbi Translocation of proteins across the cell envelope of Gram-positive bacteria
    K H van Wely
    Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
    FEMS Microbiol Rev 25:437-54. 2001
  83. ncbi The effect of biogenic amine production by single bacterial cultures and metabiosis on cold-smoked salmon
    L V Jørgensen
    Danish Institute for Fisheries Research, Department of Seafood Research, Technical University of Denmark, Lyngby, Denmark
    J Appl Microbiol 89:920-34. 2000
    ..Biogenic amines are important indicators of spoilage in vacuum-packed cold-smoked salmon. It is the aim of this study to identify bacteria responsible for biogenic amine production in cold-smoked salmon...
  84. ncbi Characterisation of volatile compounds produced by bacteria isolated from the spoilage flora of cold-smoked salmon
    J J Joffraud
    IFREMER, Laboratoire de Génie Alimentaire, Nantes, France
    Int J Food Microbiol 66:175-84. 2001
    ..Sensory analysis showed relationships between bacteria, the composition of the volatile fraction and the organoleptic quality of smoked salmon...
  85. pmc Charge effect on the photoinactivation of Gram-negative and Gram-positive bacteria by cationic meso-substituted porphyrins
    Eliana Alves
    Department of Biology and CESAM, University of Aveiro, 3810 193 Aveiro, Portugal
    BMC Microbiol 9:70. 2009
    ..The present study complements our previous work on the search for photosensitizers that might be considered good candidates for the photoinactivation of a large spectrum of environmental microorganisms...
  86. ncbi Quorum sensing in bacteria
    M B Miller
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    Annu Rev Microbiol 55:165-99. 2001
    ..Presumably, this process bestows upon bacteria some of the qualities of higher organisms. The evolution of quorum sensing systems in bacteria could, therefore, have been one of the early steps in the development of multicellularity...
  87. ncbi Trends in antimicrobial susceptibility in UK centres: the MYSTIC Programme (1997-2002)
    Robert G Masterton
    Crosshouse Hospital, Kilmarnock, Aryshire, UK
    Int J Antimicrob Agents 27:69-72. 2006
    ..Although all antibiotics tested retained acceptable activity, the carbapenems remained the most active antimicrobial agents against Gram-negative bacteria, including ESBL- and AmpC-producing isolates...
  88. ncbi An antibiotic with activity against gram-positive bacteria from the gentamicin-producing strain of Micromonospora purpurea
    K Rusnak
    Biology Department, Drew University, Madison, New Jersey, USA
    Appl Microbiol Biotechnol 56:502-3. 2001
    ..A mixture of polycyclic aromatic compounds with activity against gram-positive bacteria was isolated from a gentamicin-producing species of Micromonospora...
  89. ncbi Assessment of pathogen occurrences and resistance profiles among infected patients in the intensive care unit: report from the SENTRY Antimicrobial Surveillance Program (North America, 2001)
    Jennifer M Streit
    The JONES Group JMI Laboratories Inc, 345 Beaver Kreek Centre, Suite A, North Liberty, IW 52317, USA
    Int J Antimicrob Agents 24:111-8. 2004
    ..Cefepime and the carbapenems (imipenem or meropenem) for Gram-negative isolates and linezolid for Gram-positive isolates, provided the broadest spectrum of in vitro activity against contemporary ICU pathogens in North America...
  90. ncbi Antibacterial, antifungal, antiplasmodial, and cytotoxic activities of Albertisia villosa
    M L Lohombo-Ekomba
    Institut supérieur des techniques médicales, B P 774 Kinshasa XI, R D Congo
    J Ethnopharmacol 93:331-5. 2004
    ..These results may partly explain and support the use of Albertisia villosa root barks for the treatment of malaria and other infectious diseases in traditional Congolese medicine...
  91. ncbi [Long term care units--nest of resistant bacteria?]
    Janne Laine
    TAYS, sisätautien vastuulaue, Infektiosairaudet ja sairaalahygienia, Tampere
    Duodecim 121:1679-81. 2005
  92. pmc In vitro and in vivo antibacterial activities of CS-023 (RO4908463), a novel parenteral carbapenem
    Tetsufumi Koga
    Biological Research Laboratories, Sankyo Co, Ltd, 2 58 Hiromachi 1 chome, Shinagawa ku, Tokyo 140 8710, Japan
    Antimicrob Agents Chemother 49:3239-50. 2005
    ..aeruginosa infections only). These results suggest that CS-023 has potential for the treatment of nosocomial bacterial infections by gram-positive and -negative pathogens, including MRSA and P. aeruginosa...
  93. ncbi Bacteriology of war wounds at the time of injury
    Clinton K Murray
    Department of Medicine, Infectious Disease Service, Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA
    Mil Med 171:826-9. 2006
    ..These data suggest that the use of broad-spectrum antibiotics with efficacy against more resistant, Gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter spp., is unnecessary in early wound management...
  94. ncbi Emerging cephalosporins
    Malcolm G P Page
    Basilea Pharmaceutica AG, PO Box, CH 4005, Basel, Switzerland
    Expert Opin Emerg Drugs 12:511-24. 2007
    ..The most advanced of these agents, ceftobiprole, is approaching registration and, if approved, will present physicians with a new paradigm in treatment of serious infections by multi-resistant organisms...
  95. ncbi Antibacterial and antifungal activities of extracts of combretum molle
    Kaleab Asres
    Department of Pharmacognosy, School of Pharmacy, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    Ethiop Med J 44:269-77. 2006
    ..Owing to the widespread traditional uses of this plant, the studyinvestigated the antimicrobial activity the bark extract of this plant against Gram positive and and Gram negative bacteria...
  96. ncbi In vitro antimicrobial activity of propolis and synergism between propolis and antimicrobial drugs
    Srdjan Stepanovic
    Department of Bacteriology, Institute of Microbiology and Immunology, School of Medicine, University of Belgrade, Dr Subotica 1, 11000 Belgrade, Serbia
    Microbiol Res 158:353-7. 2003
    ..The shown antimicrobial potential of propolis alone or in combination with certain antibiotics and antifungals is of potential medical interest...
  97. ncbi [Surveillance of antimicrobial resistance of bacteria isolated from bloodstream infections: data of the French National Observatory for Epidemiology of Bacterial Resistance to Antibiotics (ONERBA), 1998-2003]
    X Bertrand
    Pour le conseil scientifique de l ONERBA
    Med Mal Infect 35:329-34. 2005
    ..The French national observatory for epidemiology of bacterial resistance to antibiotics (ONERBA) includes numerous networks for the surveillance of bacterial resistance to antibiotics...
  98. ncbi Microbial sensitivity pattern in urinary tract infections in children: a single center experience of 1,177 urine cultures
    Mostafa Sharifian
    Pediatric Infectious Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Jpn J Infect Dis 59:380-2. 2006
    ..Therefore, the selection of antibiotics for empiric therapy should be based on the sensitivity and resistance pattern of uropathogens in the respective city...
  99. ncbi Clinical effect of intravenous ciprofloxacin on hospital-acquired pneumonia
    Niro Okimoto
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School Kawasaki Hospital, 2 1 80 Nakasange, Okayama, 700 0821, Japan
    J Infect Chemother 11:52-4. 2005
    ..4%), but all side effects were mild. Based on the above data, intravenous CPFX may be the drug which should be recommended as the first choice for hospital-acquired pneumonia...
  100. ncbi In vitro evaluation of tigecycline and comparative agents in 3049 clinical isolates: 2001 to 2002
    Samuel K Bouchillon
    Laboratories International for Microbiology Studies, Schaumburg, IL 60179, USA
    Diagn Microbiol Infect Dis 51:291-5. 2005
  101. ncbi New aromatic compounds from the marine mangrove Bruguiera gymnorrhiza
    Li Han
    Hans Knöll Institute for Natural Products Research, Jena, Germany
    Planta Med 71:160-4. 2005
    ..All structures have been determined by NMR spectroscopic studies. Among them, 3 showed moderate activity against Gram-positive and Gram-negative bacteria including mycobacteria and resistant strains (MICs 12.5 microg/mL)...

Research Grants73

  1. Targeting superbugs: discovery and development of new broad-spectrum lipopeptides
    Jian Li; Fiscal Year: 2013
    ..aeruginosa, A. baumannii and K. pneumoniae. Overall, this project targets the urgent global unmet medical need and responds in a timely manner to the recent global call for discovery of new antibiotics: The 10 x '20 Initiative. ..
  2. Development of a Novel PolC Inhibitor as a Gram-Positive Antibiotic
    THALE CROSS JARVIS; Fiscal Year: 2013
    ..This project represents a compelling opportunity to combat the rising tide of antibiotic-resistant infections, providing a much-needed public health benefit. ..
  3. Transcriptional Control by the Global Regulator Spx
    PETER A ZUBER; Fiscal Year: 2013
    ..The regulatory protein Spx controls important components of the bacterial response to oxidative attack, and the study of its mechanism of action will uncover targets for neutralizing infectious microorganisms. ..
  4. Cellular functions of the essential PcrA helicase in Staphylococcus aureus
    Saleem A Khan; Fiscal Year: 2013
    ..aureus. Since PcrA is a conserved protein, the knowledge gained from these studies could be used in the future for the development of drugs against S. aureus and other Gram-positive human pathogens. ..
  5. High-throughput Screenings to Identify Host Receptors for Staphylococcal Adhesins
    Renata Pasqualini; Fiscal Year: 2012
    ..Our research aims to better understand staphylococcal infection and to set the grounds for targeted therapies against this disease. ..
  6. Lactoferrin for Immunomodulation of Systemic Inflammatory Response Syndrome
    Marian L Kruzel; Fiscal Year: 2011
    ..The goal of this proposal is to examine the utility of a novel human recombinant Lactoferrin to combat SIRS, and limit progression of SIRS. ..
    JANET L YOTHER; Fiscal Year: 2012
    ..By understanding the mechanisms involved in this process, we may be better able to develop means for treating and preventing these infections. ..
  8. Role of NOD2 in Inflammatory Arthritis and Innate Immunity
    MICHAEL PATRICK DAVEY; Fiscal Year: 2012
    ..analyze inflammatory arthritis triggered by intra-articular injection of peptidoglycan from cell walls of Gram positive bacteria, b) zymosan and c) double stranded viral RNA and d) by systemic administration of live Group B ..
  9. Branched-chain fatty acids and membrane function in Listeria monocytogenes
    BRIAN JAMES WILKINSON; Fiscal Year: 2012
    ..Novel methods for controlling the growth of the organism are expected to be developed as a result of the work. ..
    Charles O Rock; Fiscal Year: 2013
    ..This research will provide a definitive answer regarding the suitability of membrane lipid synthesis in Gram-positive pathogens as a target for novel antibacterial drug discovery development. ..
  11. Role of the Spx Regulator in Streptococcus mutans
    JOSE A LEMOS; Fiscal Year: 2013
    ..mutans to adhere to the tooth, produce acids, and survive acidic conditions in the oral cavity. Our studies will facilitate the discovery of new products that could be used to reduce or eliminate caries. ..
  12. Role and function of Spx paralogs of Bacillus anthracis
    PETER A ZUBER; Fiscal Year: 2012
  13. Interactions between Bacterial Tyrosine Kinases and Phosphatases
    Ranajeet Ghose; Fiscal Year: 2013
    ..The results of our research that aims to elucidate this regulatory mechanism should facilitate the design of antibacterial therapeutics targeting this pathway. ..
  14. Investigating the role of Bacillithiol in metal ion homeostasis and the reactive
    Pete Chandrangsu; Fiscal Year: 2013
  15. Novel aryl-rhodanine inhibitors of Streptococcus mutans biofilms
    TIMOTHY J OPPERMAN; Fiscal Year: 2012
    ..g. toothpaste or mouthwashes), where aryl-rhodanines will prevent recolonization of the teeth and subsequent biofilm formation by S. mutans, but not commensal organisms ..
    John D Sheppard; Fiscal Year: 2010
    ..It is bacteriocidal for both gram negative and gram positive bacteria at low micromolar concentrations...
  17. Structure and Function of S-adenosyl-L-methionine Riboswitches
    Ailong Ke; Fiscal Year: 2013
  18. Nitric Oxide-Releasing Wound Dressing for Preventing Chronic Wound Infections
    NATHAN ALLAN STASKO; Fiscal Year: 2012
    ..The Company has assembled a strong team of scientists, clinicians, contractors, and business leaders who believe in the technology and are positioned to ensure the greatest likelihood for success. ..
  19. Cell Surface Protein Anchoring and Function in Gram-Positive Bacteria
    ROBERT THOMPSON CLUBB; Fiscal Year: 2013
    ..Collectively, this research will increase our understanding of the molecular basis of S. aureus pathogenesis and it could lead to new therapeutics to treat bacterial infections. ..
  20. Computational Assembly of Beta Barrel Membrane Protein
    Jie Liang; Fiscal Year: 2013
    ..Extensive mutant studies will be carried out to test whether designed ?-barrel membrane proteins have the intended changes in stability, in oligomerization state, as well as in geometry. ..
  21. Interaction between B. cereus RecQ helicase and topoisomerase III
    Zhiyu Li; Fiscal Year: 2010
    ..These studies may also benefit antibiotic design targeting bacterial type IA topoisomerase and RecQ helicase. ..
  22. Glycopeptide Complexes with Bacterial Cell Walls by REDOR NMR
    Jacob Schaefer; Fiscal Year: 2013
  23. Contribution of catabolite control protein A to group A streptococcal virulence
    Samuel A Shelburne; Fiscal Year: 2013
    ..Such information could form the basis for the development of novel therapeutic or preventive interventions. ..
  24. A synergy-based therapy against C. difficile
    Kim Lewis; Fiscal Year: 2013
    ..However, MDR inhibitors increase the activity of berberine against gram positive bacteria, including C. difficile, by more than 60 fold...
  25. Glucose regulation of bacterial virulence in diabetes and hyperglycemia
    JANET L YOTHER; Fiscal Year: 2013
    ..Because other bacteria use similar mechanisms to respond to glucose, the results may have broad relevance for infections in hyperglycemic conditions. ..
  26. Integrating Global Responses to Nutrient Limitation in Gram-positive Bacteria
    Shaun R Brinsmade; Fiscal Year: 2012
  27. Molecular bssis of mef-mediated antibiotic resistance in Streptococcus pneumoniae
    David S Stephens; Fiscal Year: 2010
    ..pneumoniae. ..
  28. 2012 New Antibacterial Drug Discovery and Development Gordon Research Conference
    Shahriar Mobashery; Fiscal Year: 2012
    Michael G Caparon; Fiscal Year: 2013
    ..This information will be important for understanding how the multiple toxins of S. pyogenes interact with each other and with host cells to unravel how this pathogen can cause such a diverse range of different diseases. ..
    George Wright; Fiscal Year: 2009
    ..GLSynthesis and Microbiotix will continue a collaborative partnership in drug discovery and development by successful completion of this project. ..
  31. Integration of metabolism and virulence in Gram-positive bacteria
    ..aureus, that expresses dozens of virulence factors that cause different extents of damage to the host, it will be possible to learn to what extent metabolite pools have to drop before the most damaging factors are induced. ..
  32. Biosynthesis and Function of Treponema denticola Lipooligosaccharide
    Hui Wu; Fiscal Year: 2013
    Olaf Schneewind; Fiscal Year: 2013
    ..Appreciation of their molecular mechanisms and the structural as well as chemical nature of their inhibition will aid in the development of small molecules with therapeutic value for the treatment of bacterial infections. ..
  34. Integrating Global Responses to Nutrient Limitation in Gram-positive Bacteria
    Shaun R Brinsmade; Fiscal Year: 2013
    ..A more thorough understanding of these connections may also offer potentially novel therapeutic strategies. The Pathway to Independence Award will provide the time and resources needed to achieve these goals. ..
  35. Bacterial Quorum Sensing as Target for Anti-Infective Immunotherapy
    Bin Zhou; Fiscal Year: 2013
    ..We propose to develop antibodies and harness the immune system in general for the disruption of bacterial quorum sensing and thus, a new strategy in fighting bacterial infections. ..
  36. Systematic Phenotypic Analysis of the Gram-positive Envelope
    Jason M Peters; Fiscal Year: 2013
    ..subtilis. The discoveries made in this study will likely extend to important Gram-positive human pathogens, as well as human commensals in the gut microbiome. ..
    Tina M Henkin; Fiscal Year: 2012
  38. Development of novel single-molecule approaches for nanoscale study of helicases
    Sanford H Leuba; Fiscal Year: 2010
    ..The experiments described here will also increase our understanding of the mechanism of action of an important group of motor proteins as exemplified by the PcrA helicase which is involved in a number of DNA transactions. ..
  39. Novel oxadiazols for the treatment of drug-resistant gram-positive bacteria
    Shahriar Mobashery; Fiscal Year: 2013
    ..Our goal is to develop a new class of antibiotics to treat drug-resistant bacterial infections. ..
  40. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth N Raymond; Fiscal Year: 2013
    ..Through the use of synthetic analogs and bacterial siderophore isolates, as well as labeled substrates and mutant proteins, we intend to describe the selectivity and physiological course of siderocalin. ..
  41. Up-regulation of Mucin Gene Transcription-Otitis Media
    Jian dong Li; Fiscal Year: 2013
    ..Overall, these studies will unveil novel molecular mechanisms underlying mucin up-regulation and identify novel therapeutic targets, leading to new therapeutic strategy for inhibiting mucus overproduction in OM (significance). ..
  42. Anti-MRSA activity of a Bacillus pumilus natural isolate
    Michiko M Nakano; Fiscal Year: 2010
    ..This proposal describes studies aimed at characterizing what might be a promising anti-MRSA substance for combating this re-emerging infectious threat. ..
  43. Directed evolution of fosfomycin resistance enzymes from a promiscuous progenitor
    Paul D Cook; Fiscal Year: 2010
  44. Intramolecular domain movements of PcrA during its helicase function
    Karen R Thickman; Fiscal Year: 2010
    ..Due to its small size, ~700 residues, and likely monomeric state, PcrA is an ideal model for furthering the understanding of helicase functions and malignancies arising from irregular helicase activities. ..
  45. Dynamics of Antimicrobial Peptide Interactions with Bacterial Membranes
    James C Weisshaar; Fiscal Year: 2013
    ..AMPs are remarkably for their general ability to halt growth of both Gram negative and Gram positive bacteria. Cationic AMPs are known to form amphipathic helices that bind to anionic cell membranes, form pores, and ..
  46. Essential Autolysin Activity in Gram-positive Bacteria
    Hendrik Szurmant; Fiscal Year: 2013
  47. Oxidative protein folding of pilins and virulence in Gram-positive bacteria
    ..The study of disulfide bond formation within these models will provide new targets to develop antimicrobial drugs. ..
  48. Molecular Assembly on the Cell Surface of Actinomyces
    Hung Ton-That; Fiscal Year: 2013
  49. Modified Bases in tRNA-Mediated Antitermination
    Edward P Nikonowicz; Fiscal Year: 2011
    ..A thorough knowledge of pathogen-specific modification may also define new targets for antimicrobial strategies. ..
  50. Prevention of Biofilm Related Infections Using a Novel, Broad Spectrum Antimicrob
    ROY DRAKE BLOEBAUM; Fiscal Year: 2013
    ..We hope this will give civilian and military patients a more sure way of avoiding infection in grossly contaminated wounds. ..
  51. Regulation of Magnesium Homeostasis in Bacillus subtilis
    Wade Winkler; Fiscal Year: 2011
    ..We will test this hypothesis by investigating posttranscriptional regulation of the candidate transport genes within the context of additional magnesium- regulated genes. ..
  52. Biphasic alcohol regulation of TLR2 in airway epithelium
    KRISTINA L BAILEY; Fiscal Year: 2013
    ..A better understanding of how alcohol influences inflammatory processes in the lung will lead to more targeted therapy of airway disease in alcoholics and result in decreased morbidity and mortality. ..
  53. Post-translation regulation of Listeria monocytogenes virulence factors
    NANCY ELIZABETH FREITAG; Fiscal Year: 2013
    ..The ultimate goal of the specific aims will be to elucidate how PrsA2 modulates the secretion and/or activity of virulence factors to promote bacterial pathogenesis in mammalian hosts. ..
  54. Role of type IV secretion-mediated protein translocation in E. faecalis
    Peter J Christie; Fiscal Year: 2013
    ..faecalis and other medically-important Gram-positive pathogens. ..
  55. New mechanism of resistance to oxazolidinone antibiotics in Staphylococcus aureus
    Alexander S Mankin; Fiscal Year: 2010
  56. Bacteriolytic phage enzymes as novel antibacterials against Yersinia pestis
    Ian Molineux; Fiscal Year: 2009
    ..pestis infections. These in vivo studies will parallel those involving lysins using the mouse model of plague infection. ..
  57. Thiazolyl peptide analogs that provide insight into antibiotic targeting
    TRAVIS SCOTT YOUNG; Fiscal Year: 2012
    ..thiazolyl peptide ring structures will have alternate or multiple targets that inhibit the growth of gram positive bacteria. Preliminary data indicates the thiazolyl peptide biosynthetic machinery should readily accept modest ..
  58. Pilus Assembly in Gram-Positive Bacteria
    Hung Ton-That; Fiscal Year: 2012
    ..The results generated will certainly provide not only a clear understanding of the basic mechanisms of pilus assembly and pilus-mediated pathogenesis in Gram-positive bacteria but also knowledge that improves health. ..
  59. Initiation and Regulation of Immune Protease Pathways
    Haobo Jiang; Fiscal Year: 2012
    ..The acquired knowledge will be useful for disrupting the transmission of human diseases in vector species. ..
  60. Antibiotic Properties of Artificial Agonists for a Bacterial Riboswitch
    JULIANE K STRAUSS SOUKUP; Fiscal Year: 2010
    ..Structure-function and mechanistic studies of riboswitches have enabled detailed analyses of ligand recognition by RNA as well as rational design of non-natural agonists that ultimately could function as antibiotics. ..
  61. Bacterial regulation of intestinal antimicrobial defense
    Lora V Hooper; Fiscal Year: 2013
    ..Together, these studies should lead to fundamental insights into immune control of bacterial-mucosal associations, and will provide new perspectives on symbiotic host-microbial associations. ..
  62. Discovery of Inhibitors of DNA Replication in Gram-Positive Bacteria
    H Garry Dallmann; Fiscal Year: 2010
  63. Structure-based mutational analysis of RNA polymerase
    KONSTANTIN V SEVERINOV; Fiscal Year: 2010
    ..The proposed work is significant from the public health standpoint since information necessary for development of new and/or improved drugs that target bacterial transcription will be obtained. ..
    JACK HAWIGER; Fiscal Year: 2003
    ..The ultimate goal of the proposed studies is to provide a new conceptual framework for reduction of high mortality due to septic shock. ..
  65. Structural Basis for Isoprenoid Biosynthesis
    JOSEPH NOEL; Fiscal Year: 2006
  66. Methylerythritol Phosphate Pathway Inhibitors Targeting Gram-Negative Infections
    CHARLES TESTA; Fiscal Year: 2009
  67. Detection of Antibiotic Resistance Genes in Bacterial Agents of Hospital-Acquired
    Andrew Levin; Fiscal Year: 2009
  68. Methylerythritol Phosphate Pathway-Specific Natural Products as Antibacterials
    CHARLES TESTA; Fiscal Year: 2009
    ..The pathway is not the target of any currently prescribed therapeutic, therefore these compounds and their derivatives are expected to have prolonged utility relative to subsequent generations of antibiotics presently in use. ..
  69. Formula with antimicrobials to decrease infant mortality
    Koteswara Chintalacharuvu; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  70. Role of Burkholderia Cenocepacia Adhesin, AdhA, in Cystic Fibrosis Infections
    Joanna B Goldberg; Fiscal Year: 2010
    ..cenocepacia. These experiments are the first steps in developing strategies to prevent the life threatening infections caused by this bacterium. ..
  71. Intervention against anthrax edema factor (EF)
    Wei Jen Tang; Fiscal Year: 2005
    ..Success in our proposal will provide the blueprint to generate the effective EF inhibitors as an adjunct therapeutic against anthrax infection. ..
    TAD KOCH; Fiscal Year: 2001
    ..The research will provide a further understanding of how secondary metabolites of microorganisms are designed to function as antibiotics without being too toxic to the microorganism which creates them. ..
  73. Pilus Assembly in Gram-Positive Bacteria
    Hung Ton That; Fiscal Year: 2010
    ..Together these studies will reveal the assembly mechanism of pili in gram-positive bacteria and the contribution of these organelles during the pathogenesis of infection. ..