Genomes and Genes
Summary: A species of rod-shaped bacteria that is a common soil saprophyte. Its spores are widespread and multiplication has been observed chiefly in foods. Contamination may lead to food poisoning.
Publications326 found, 100 shown here
- ExsY and CotY are required for the correct assembly of the exosporium and spore coat of Bacillus cereusMatt J Johnson
Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
J Bacteriol 188:7905-13. 2006The exosporium-defective phenotype of a transposon insertion mutant of Bacillus cereus implicated ExsY, a homologue of B. subtilis cysteine-rich spore coat proteins CotY and CotZ, in assembly of an intact exosporium...
- Bacillus cereus, a volatile human pathogenEdward J Bottone
Division of Infectious Diseases, Box 1090, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Clin Microbiol Rev 23:382-98. 2010b>Bacillus cereus is a Gram-positive aerobic or facultatively anaerobic, motile, spore-forming, rod-shaped bacterium that is widely distributed environmentally. While B...
- AnthraxM Mock
Toxines et Pathogénie Bactérienne, CNRS URA 2172, Institut Pasteur, Paris Cedex 15, France
Annu Rev Microbiol 55:647-71. 2001..Spore-structure analysis could contribute to the improvement of human nonliving vaccines. The phylogeny of B. anthracis within the Bacillus cereus group is also reviewed.
- From soil to gut: Bacillus cereus and its food poisoning toxinsLotte P Stenfors Arnesen
Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, Oslo, Norway
FEMS Microbiol Rev 32:579-606. 2008b>Bacillus cereus is widespread in nature and frequently isolated from soil and growing plants, but it is also well adapted for growth in the intestinal tract of insects and mammals...
- Expanding the known repertoire of virulence factors produced by Bacillus cereus through early secretome profiling in three redox conditionsGérémy Clair
UMR408, Universite d Avignon et des Pays de Vaucluse, F 84000 Avignon, France
Mol Cell Proteomics 9:1486-98. 2010The pathogen Bacillus cereus causes diarrheal disease in humans. In the small intestine, B. cereus has to deal with anaerobiosis, low oxidoreduction potential, and carbohydrate limitation conditions...
- DNA as an adhesin: Bacillus cereus requires extracellular DNA to form biofilmsSebastien Vilain
Department of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA
Appl Environ Microbiol 75:2861-8. 2009The soil saprophyte Bacillus cereus forms biofilms at solid-liquid interfaces...
- Enterotoxigenic profiles of food-poisoning and food-borne Bacillus cereus strainsMarie Helene Guinebretiere
Institut National de la Recherche Agronomique, UMR A408 Sécurité et Qualité des Produits d Origine Végétale, INRA, Domaine Saint Paul, Site Agroparc, F 84914 Avignon Cedex 9, France
J Clin Microbiol 40:3053-6. 2002..Unlike diarrheal strains, food-borne strains showed frequent nhe and hbl gene polymorphisms and were often low toxin producers...
- What sets Bacillus anthracis apart from other Bacillus species?Anne Brit Kolstø
Laboratory for Microbial Dynamics and Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo 0316, Norway
Annu Rev Microbiol 63:451-76. 2009..cereus and B. thuringiensis. Coevolution of the B. anthracis chromosome with its plasmids may be the basis for the successful development and uniqueness of the B. anthracis lineage...
- The effect of lemon, orange and bergamot essential oils and their components on the survival of Campylobacter jejuni, Escherichia coli O157, Listeria monocytogenes, Bacillus cereus and Staphylococcus aureus in vitro and in food systemsK Fisher
School of Health, The University of Northampton, Northampton, UK
J Appl Microbiol 101:1232-40. 2006..To investigate the effectiveness of oils and vapours of lemon (Citrus limon), sweet orange (Citrus sinensis) and bergamot (Citrus bergamia) and their components against a number of common foodborne pathogens...
- The PlcR virulence regulon of Bacillus cereusMichel Gohar
INRA, Génétique microbienne et Environnement, Guyancourt, France michel gohar jouy inra fr
PLoS ONE 3:e2793. 2008PlcR is a Bacillus cereus transcriptional regulator, which activates gene expression by binding to a nucleotidic sequence called the 'PlcR box'...
- Bacillus cereus bacteremia outbreak due to contaminated hospital linensT Sasahara
Department of Infection and Immunity, School of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi, 329 0498, Japan
Eur J Clin Microbiol Infect Dis 30:219-26. 2011We describe an outbreak of Bacillus cereus bacteremia that occurred at Jichi Medical University Hospital in 2006. This study aimed to identify the source of this outbreak and to implement appropriate control measures...
- The phenolic hydroxyl group of carvacrol is essential for action against the food-borne pathogen Bacillus cereusA Ultee
Wageningen Centre for Food Sciences, Department of Preservation Technology and Food Safety, Agrotechnological Research Institute ATO B V, Wageningen, The Netherlands
Appl Environ Microbiol 68:1561-8. 2002..The resulting collapse of the proton motive force and depletion of the ATP pool eventually lead to cell death...
- Characterization of type II and III restriction-modification systems from Bacillus cereus strains ATCC 10987 and ATCC 14579Shuang yong Xu
New England Biolabs, Inc, Ipswich, Massachusetts, USA
J Bacteriol 194:49-60. 2012The genomes of two Bacillus cereus strains (ATCC 10987 and ATCC 14579) have been sequenced. Here, we report the specificities of type II/III restriction (R) and modification (M) enzymes...
- A cell-cell communication system regulates protease production during sporulation in bacteria of the Bacillus cereus groupStéphane Perchat
INRA, UMR 1319 Micalis, La Minière, 78280 Guyancourt, France
Mol Microbiol 82:619-33. 2011..We investigated the role of one such regulator, NprR, in bacteria of the Bacillus cereus group. We show that NprR is a transcriptional regulator whose activity depends on the NprX signalling peptide...
- Molecular basis for group-specific activation of the virulence regulator PlcR by PapR heptapeptidesL Bouillaut
INRA, UR1249, F 78285 Guyancourt, France
Nucleic Acids Res 36:3791-801. 2008..system that controls the expression of extra-cellular virulence factors in various species of the Bacillus cereus group. PlcR and PapR alleles are clustered into four groups defining four pherotypes...
- The hidden lifestyles of Bacillus cereus and relativesG B Jensen
National Institute of Occupational Health, Lersø Parkallé 105, 2100 Copenhagen, Denmark
Environ Microbiol 5:631-40. 2003b>Bacillus cereus sensu lato, the species group comprising Bacillus anthracis, Bacillus thuringiensis and B. cereus (sensu stricto), has previously been scrutinized regarding interspecies genetic correlation and pathogenic characteristics...
- Haemolysin II is a Bacillus cereus virulence factor that induces apoptosis of macrophagesSeav Ly Tran
INRA, Unité MICALIS, UMR 1319, Equipe GME, La Minière, 78285 Guyancourt, France
Cell Microbiol 13:92-108. 2011b>Bacillus cereus is a Gram-positive spore-forming bacterium causing food poisoning and serious opportunistic infections. These infections are characterized by bacterial accumulation despite the recruitment of phagocytic cells...
- Fatal family outbreak of Bacillus cereus-associated food poisoningKatelijne Dierick
Institute of Public Health, Food Section, 14 Juliette Wijtsman Str, B 1050 Brussels, Belgium
J Clin Microbiol 43:4277-9. 2005b>Bacillus cereus is a well-known cause of food-borne illness, but infection with this organism is not commonly reported because of its usually mild symptoms...
- The InhA metalloproteases of Bacillus cereus contribute concomitantly to virulenceElisabeth Guillemet
Unité Génétique Microbienne et Environnement, INRA, La Minière, 78285 Guyancourt Cedex, France
J Bacteriol 192:286-94. 2010The virulence of Bacillus cereus requires that bacteria have the capacity to colonize their host, degrade specific tissues, and circumvent the host immune system...
- Three Bacillus cereus bacteriophage endolysins are unrelated but reveal high homology to cell wall hydrolases from different bacilliM J Loessner
Institut fur Mikrobiologie, Forschungszentrum fur Milch und Lebensmittel Weihenstephan, Technische Universitat Munchen, Freising, Germany
J Bacteriol 179:2845-51. 1997The ply genes encoding the endolysin proteins from Bacillus cereus phages Bastille, TP21, and 12826 were identified, cloned, and sequenced...
- Growth of microorganisms in total parenteral nutrition solutions containing lipidTakashi Kuwahara
Preclinical Assessment Department, Otsuka Pharmaceutical Factory, Inc, Tokushima, Japan
Int J Med Sci 7:101-9. 2010..nutrition (TPN) solutions, we investigated the growth of the major causes of catheter-related blood stream infection (Staphylococcus aureus, Serratia marcescens, Bacillus cereus, and Candida albicans) in TPN solutions containing lipid.
- Extended and global phylogenetic view of the Bacillus cereus group population by combination of MLST, AFLP, and MLEE genotyping dataNicolas J Tourasse
Laboratory for Microbial Dynamics LaMDa and Department of Pharmaceutical Biosciences Microbiology, University of Oslo, N 0316 Oslo, Norway
Food Microbiol 28:236-44. 2011The Bacillus cereus group of bacteria includes species that can cause food-poisoning or spoilage, such as B. cereus, as well as Bacillus anthracis, the cause of anthrax...
- Mechanisms of action of carvacrol on the food-borne pathogen Bacillus cereusA Ultee
Agrotechnological Research Institute, 6700 AA Wageningen, The Netherlands
Appl Environ Microbiol 65:4606-10. 1999..thyme, was studied for its effect on bioenergetic parameters of vegetative cells of the food-borne pathogen Bacillus cereus. Incubation for 30 min in the presence of 1 to 3 mM carvacrol reduced the viable cell numbers exponentially...
- Ecological diversification in the Bacillus cereus GroupMarie Helene Guinebretiere
Institut National de Recherche Agronomique, UMR A408 Sécurité et Qualité des Produits d Origine Végétale, INRA, Domaine Saint Paul, Site Agroparc, F 84914 Avignon Cedex 9, France
Environ Microbiol 10:851-65. 2008The Bacillus cereus Group comprises organisms that are widely distributed in the environment and are of health and economic interest. We demonstrate an 'ecotypic' structure of populations in the B...
- Quantitative analysis of population heterogeneity of the adaptive salt stress response and growth capacity of Bacillus cereus ATCC 14579Heidy M W den Besten
TI Food and Nutrition, Wageningen, The Netherlands
Appl Environ Microbiol 73:4797-804. 2007..The growth dynamics of Bacillus cereus ATCC 14579 during mild and severe salt stress exposure were investigated for the population as a whole in ..
- Iron regulates expression of Bacillus cereus hemolysin II via global regulator FurElena Sineva
Laboratory of Molecular Microbiology, Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow Region, Russia
J Bacteriol 194:3327-35. 2012..b>Bacillus cereus is a widely distributed bacterium with distinct pathogenic properties...
- Expression of Bacillus cereus hemolysin II in Bacillus subtilis renders the bacteria pathogenic for the crustacean Daphnia magnaElena V Sineva
Laboratory of Molecular Microbiology, Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow Region, Russia
FEMS Microbiol Lett 299:110-9. 2009Hemolysin II (HlyII) is a pore-forming toxin of the opportunistic pathogen Bacillus cereus. Despite our understanding of the mechanism of HlyII cytotoxicity in vitro, many of its characteristics, including potential target cells, ..
- A new Bacillus cereus DNA-binding protein, HlyIIR, negatively regulates expression of B. cereus haemolysin IIZhanna I Budarina
The Institute of Biochemistry and Physiology of Micro organisms, Nauki Avenue, 5, Pushchino, 142292 Russia
Microbiology 150:3691-701. 2004Haemolysin II, HlyII, is one of several cytotoxic proteins produced by Bacillus cereus, an opportunistic human pathogen that causes food poisoning. The hlyII gene confers haemolytic activity to Escherichia coli cells. Here a new B...
- Bacillus cereus nosocomial infection from reused towels in JapanS Dohmae
Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
J Hosp Infect 69:361-7. 2008It was noticed that there was an increase in Bacillus cereus nosocomial infections in the summer from 2000 to 2005. In 2005, five bloodstream infections occurred in five patients related to catheter use...
- Role of the five RNA helicases in the adaptive response of Bacillus cereus ATCC 14579 cells to temperature, pH, and oxidative stressesFranck Pandiani
INRA, UMR408 Sécurité et Qualité des Produits d Origine Végétale, Avignon, France
Appl Environ Microbiol 77:5604-9. 2011In this study, growth rates and lag times of the five RNA helicase-deleted mutants of Bacillus cereus ATCC 14579 were compared to those of the wild-type strain under thermal, oxidative, and pH stresses...
- The InhA1 metalloprotease allows spores of the B. cereus group to escape macrophagesNalini Ramarao
Unité Génétique Microbienne et Environnement, Institut National de la Recherche Agronomique, La Minière, 78285 Guyancourt Cedex, France
Cell Microbiol 7:1357-64. 2005Bacteria of the Bacillus cereus group are resistant to the immune systems of various hosts and establish potent infections, implying that bacteria circumvent the bactericidal activity of host phagocytic cells...
- Bacillus cereus, the causative agent of an emetic type of food-borne illnessMonika Ehling-Schulz
Abt Mikrobiologie, ZIEL, Technische Universitat Munchen, Freising, Germany
Mol Nutr Food Res 48:479-87. 2004b>Bacillus cereus is the causative agent of two distinct forms of gastroenteritic disease connected to food-poisoning. It produces one emesis-causing toxin and three enterotoxins that elicit diarrhea...
- Rapid degradation of N-3-oxo-acylhomoserine lactones by a Bacillus cereus isolate from Malaysian rainforest soilKok Gan Chan
Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
Antonie Van Leeuwenhoek 98:299-305. 2010..KM1S was clustered closely to Bacillus cereus by 16S ribosomal DNA sequence analysis...
- Low concentrations of bile salts induce stress responses and reduce motility in Bacillus cereus ATCC 14579 [corrected]Simen M Kristoffersen
Department of Molecular Biosciences, University of Oslo, PB1041 Blindern, 0316 Oslo, Norway
J Bacteriol 189:5302-13. 2007Tolerance to bile salts was investigated in forty Bacillus cereus strains, including 17 environmental isolates, 11 dairy isolates, 3 isolates from food poisoning outbreaks, and 9 other clinical isolates...
- PCR fingerprinting of whole genomes: the spacers between the 16S and 23S rRNA genes and of intergenic tRNA gene regions reveal a different intraspecific genomic variability of Bacillus cereus and Bacillus licheniformis [corrected]D Daffonchio
Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche DISTAM, Universita degli Studi, Milano, Italy
Int J Syst Bacteriol 48:107-16. 1998Genomic diversity in 21 strains of Bacillus cereus and 10 strains of Bacillus licheniformis was investigated by random amplified polymorphic DNA (RAPD) analysis, which samples the whole genome, and by two PCR fingerprinting techniques ..
- A Bacillus cereus cytolytic determinant, cereolysin AB, which comprises the phospholipase C and sphingomyelinase genes: nucleotide sequence and genetic linkageM S Gilmore
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City 73190
J Bacteriol 171:744-53. 1989A cloned cytolytic determinant from the genome of Bacillus cereus GP-4 has been characterized at the molecular level. Nucleotide sequence determination revealed the presence of two open reading frames...
- Biosurfactant production and surface translocation are regulated by PlcR in Bacillus cereus ATCC 14579 under low-nutrient conditionsYi Huang Hsueh
Department of Bacteriology, Food Research Institute, University of Wisconsin Madison, 1550 Linden Drive, Madison, WI 53706, USA
Appl Environ Microbiol 73:7225-31. 2007b>Bacillus cereus ATCC 14579 can respond to nutrient changes by adopting different forms of surface translocation. The B...
- Bacillus cereus cytotoxins Hbl, Nhe and CytK are secreted via the Sec translocation pathwayAnnette Fagerlund
Norwegian School of Veterinary Science, Department of Food Safety and Infection Biology, PO Box 8146 Dep, N 0033 Oslo, Norway
BMC Microbiol 10:304. 2010b>Bacillus cereus and the closely related Bacillus thuringiensis are Gram positive opportunistic pathogens that may cause food poisoning, and the three secreted pore-forming cytotoxins Hbl, Nhe and CytK have been implicated as the ..
- Insertional mutagenesis reveals genes involved in Bacillus cereus ATCC 14579 growth at low temperatureVeronique Broussolle
INRA, UMR Securite et Qualite des Produits d Origine Vegetale, Avignon, France
FEMS Microbiol Lett 306:177-83. 2010Transposon mutagenesis of Bacillus cereus ATCC 14579 yielded cold-sensitive mutants...
- Crystal structure of the phosphatidylinositol-specific phospholipase C from Bacillus cereus in complex with myo-inositolD W Heinz
Institut fur Organische Chemie und Biochemie, Universitat Freiburg, Germany
EMBO J 14:3855-63. 1995..The crystal structure of PI-PLC from Bacillus cereus (EC 18.104.22.168) has been solved at 2.6 A resolution and refined to a crystallographic R factor of 18.7%...
- Comparative analysis of the virulence of invertebrate and mammalian pathogenic bacteria in the oral insect infection model Galleria mellonellaS Fedhila
Unité Protéomie Fonctionnelle et Biopréservation Alimentaire, Institut Supérieur des Sciences, Biologiques Appliquées de Tunis, Universite Tunis El Manar, Tunis, Tunisia
J Invertebr Pathol 103:24-9. 2010..can function as an oral infection model for human and entomo-bacterial pathogens, we tested strains of Bacillus cereus, Bacillus anthracis, Enterococcus faecalis, Listeria monocytogenes, Pseudomonas aeruginosa and a Drosophila ..
- LmbE proteins from Bacillus cereus are de-N-acetylases with broad substrate specificity and are highly similar to proteins in Bacillus anthracisAlexandra Deli
Department of Biology, Enzyme Biotechnology Group, University of Crete, Heraklion, Crete, Greece
FEBS J 277:2740-53. 2010The genomes of Bacillus cereus and its closest relative Bacillus anthracis each contain two LmbE protein family homologs: BC1534 (BA1557) and BC3461 (BA3524)...
- Trypan blue dye enters viable cells incubated with the pore-forming toxin HlyII of Bacillus cereusSeav Ly Tran
INRA, Unité MICALIS, UMR 1319, Guyancourt, France
PLoS ONE 6:e22876. 2011..Here, we show that the pore-forming toxin HlyII of Bacillus cereus allows trypan blue staining of macrophage cells, despite the cells remaining viable and metabolically active...
- Transcriptional responses of Bacillus cereus towards challenges with the polysaccharide chitosanHilde Mellegård
Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, Oslo, Norway
PLoS ONE 6:e24304. 2011..This paper reports the transcriptome profiling using DNA microarrays of the type-strain of Bacillus cereus (ATCC 14579) exposed to subinhibitory concentrations of two water-soluble chitosan preparations with defined ..
- Influence of carvacrol on growth and toxin production by Bacillus cereusA Ultee
Agrotechnological Research Institute ATO DLO, Wageningen, The Netherlands Wageningen Centre for Food Sciences, Wageningen, The Netherlands
Int J Food Microbiol 64:373-8. 2001The natural antimicrobial compound carvacrol was investigated for its effect on diarrheal toxin production by Bacillus cereus. Carvacrol (0-0.06 mg/ml) reduced the viable count and the maximal specific growth rate (mumax) of B...
- Bacillus cereus food poisoning and its toxinsJean L Schoeni
Department of Food Microbiology and Toxicology, Food Research Institute, University of Wisconsin, Madison, Wisconsin 53706, USA
J Food Prot 68:636-48. 2005..b>Bacillus cereus causes two types of food poisoning, the emetic and diarrheal syndromes, and a variety of local and systemic ..
- Global transcriptome analysis of Bacillus cereus ATCC 14579 in response to silver nitrate stressMalli Mohan Ganesh Babu
Department of Genetics, Centre for Excellence in Genomic Sciences, School of Biological Sciences, Madurai Kamaraj University, Tamil Nadu, India
J Nanobiotechnology 9:49. 2011Silver nanoparticles (AgNPs) were synthesized using Bacillus cereus strains. Earlier, we had synthesized monodispersive crystalline silver nanoparticles using B. cereus PGN1 and ATCC14579 strains...
- The dlt operon of Bacillus cereus is required for resistance to cationic antimicrobial peptides and for virulence in insectsZ Abi Khattar
INRA, UMR 1133, Laboratoire EMIP, Place Eugene Bataillon, F 34095 Montpellier, France
J Bacteriol 191:7063-73. 2009..We investigated the role of the dlt operon in insect virulence by inactivating this operon in Bacillus cereus, which is both an opportunistic human pathogen and an insect pathogen...
- Differential involvement of the five RNA helicases in adaptation of Bacillus cereus ATCC 14579 to low growth temperaturesFranck Pandiani
INRA, UMR408, Sécurité et Qualité des Produits d Origine Végétale, Avignon, France
Appl Environ Microbiol 76:6692-7. 2010b>Bacillus cereus ATCC 14579 possesses five RNA helicase-encoding genes overexpressed under cold growth conditions. Out of the five corresponding mutants, only the ΔcshA, ΔcshB, and ΔcshC strains were cold sensitive...
- Virulence of Bacillus cereus: a multivariate analysisJ Minnaard
Centro de Investigación y Desarrollo en Criotecnología de Alimentos, Catedra de Microbiologia, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina
Int J Food Microbiol 116:197-206. 2007Biological activity and presence of DNA sequences related to virulence genes were studied in 21 strains of the Bacillus cereus group...
- Whole-genome phylogenies of the family Bacillaceae and expansion of the sigma factor gene family in the Bacillus cereus species-groupTimothy R Schmidt
Department of Microbiology and Immunology, Oklahoma University Health Sciences Center, Oklahoma City, OK 73117 USA
BMC Genomics 12:430. 2011The Bacillus cereus sensu lato group consists of six species (B. anthracis, B. cereus, B. mycoides, B. pseudomycoides, B. thuringiensis, and B. weihenstephanensis)...
- Two HlyIIR dimers bind to a long perfect inverted repeat in the operator of the hemolysin II gene from Bacillus cereusEkaterina A Rodikova
Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Prospekt Nauki 5, Pushchino, Moscow Region 142290, Russia
FEBS Lett 581:1190-6. 2007..Two HlyIIR dimers were found to bind to native operator independently with Kd level in the nanomolar range. The minimal HlyIIR binding site was identified as a half of the long DNA perfect inverted repeat...
- Detection of large plasmids from the Bacillus cereus groupLars Andrup
National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
Plasmid 59:139-43. 2008The members of the Bacillus cereus group, Bacillus anthracis, Bacillus thuringiensis, and B. cereus senso stricto, are largely defined by their content of large plasmids, which encode major virulence factors...
- Hemolysis induced by Bacillus cereus sphingomyelinaseMasataka Oda
Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima, Japan 770 8514
Biochim Biophys Acta 1798:1073-80. 2010b>Bacillus cereus sphingomyelinase (Bc-SMase) induces hemolysis of sheep erythrocytes which contain large amounts of sphingomyelin...
- Comparison of cytotoxin cytK promoters from Bacillus cereus strain ATCC 14579 and from a B. cereus food-poisoning strainJulien Brillard
Institut Pasteur, Génétique et Physiologie des Bacillus Pathogènes, Département de Microbiologie Fondamentale et Médicale, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Microbiology 150:2699-705. 2004The cytotoxin CytK produced by Bacillus cereus is believed to be involved in food-borne diseases...
- Regulation of toxin production by Bacillus cereus and its food safety implicationsSiele Ceuppens
Ghent University, Faculty of Bioscience Engineering, Laboratory of Food Microbiology and Food Preservation, Ghent, Belgium
Crit Rev Microbiol 37:188-213. 2011..The food safety aspects and management tools such as temperature control, food preservatives and modified atmosphere packaging are discussed specifically for B. cereus emetic and diarrheal toxin production...
- Monoclonal antibodies neutralize Bacillus cereus Nhe enterotoxin by inhibiting ordered binding of its three exoprotein componentsAndrea Didier
Department of Veterinary Sciences, Faculty of Veterinary Medicine, Ludwig Maximilians Universitat Munchen, Oberschleissheim, Germany
Infect Immun 80:832-8. 2012The Nhe enterotoxin from Bacillus cereus is known to induce cytotoxicity on Vero and CaCo-2 cells by ordered binding of its single components NheA, NheB, and NheC...
- IlsA, a unique surface protein of Bacillus cereus required for iron acquisition from heme, hemoglobin and ferritinNadine Daou
INRA UR1249 Génétique Microbienne et Environnement, La Minière, Guyancourt, France
PLoS Pathog 5:e1000675. 2009The human opportunistic pathogen Bacillus cereus belongs to the B. cereus group that includes bacteria with a broad host spectrum. The ability of these bacteria to colonize diverse hosts is reliant on the presence of adaptation factors...
- Contamination of hospital linen by Bacillus cereusD Barrie
Department of Medical Microbiology, Charing Cross and Westminster Medical School, London
Epidemiol Infect 113:297-306. 1994An investigation into two cases of post-operative Bacillus cereus meningitis revealed that hospital linen laundered by a batch continuous washing machine was heavily contaminated by B. cereus spores...
- Sudden death of a young adult associated with Bacillus cereus food poisoningMaria Naranjo
Scientific Institute of Public Health, 14 Juliette Wytsman Str, B 1050 Brussels, Belgium
J Clin Microbiol 49:4379-81. 2011..A 20-year-old man died following the ingestion of pasta contaminated with Bacillus cereus. Emetic strains of B. cereus were isolated, and high levels of cereulide (14...
- Complete nucleotide sequence and molecular characterization of hemolysin II gene from Bacillus cereusG Baida
Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Moscow Region, 142292, Pushchino, Russia
FEMS Microbiol Lett 180:7-14. 1999Hemolysin II gene from Bacillus cereus VKM-B771 has been sequenced. The deduced primary translation product consists of 412 amino acid residues which corresponds to the protein with an M(r) of 45.6 kDa...
- Characterization and genomic analysis of chromate resistant and reducing Bacillus cereus strain SJ1Minyan He
State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China
BMC Microbiol 10:221. 2010..Our main aim was to investigate chromate resistance and reduction by Bacillus cereus SJ1, and to further study the underlying mechanisms at the molecular level using the obtained genome sequence.
- Characterization of Bacillus probiotics available for human useLe H Duc
School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey TW20 OEX, United Kingdom
Appl Environ Microbiol 70:2161-71. 2004Bacillus species (Bacillus cereus, Bacillus clausii, Bacillus pumilus) carried in five commercial probiotic products consisting of bacterial spores were characterized for potential attributes (colonization, immunostimulation, and ..
- The occurrence of Bacillus cereus, B. thuringiensis and B. mycoides in Chinese pasteurized full fat milkGuoping Zhou
State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
Int J Food Microbiol 121:195-200. 2008..The single B. mycoides isolate harbored nheA and nheC genes. The data provides information for further evaluating the effect of B. cereus-like bacteria on food safety of Chinese milk products...
- Bacterial contamination in the environment of food factories processing ready-to-eat fresh vegetablesK Kaneko
Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Japan
J Food Prot 62:800-4. 1999..b>Bacillus cereus was isolated from 9 of 86 and 17 of 85 samples examined before and after operation with the number of 2...
- Prevalence of Bacillus cereus bacteriophages in fermented foods and characterization of phage JBP901Hakdong Shin
Department of Food and Animal Biotechnology, Center for Agricultural Biomaterials and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea
Res Microbiol 162:791-7. 2011b>Bacillus cereus is widely distributed in the environment and is responsible for foodborne illnesses, causing diarrhea and vomiting. In this study, the prevalence of B...
- Identification of sigmaB-dependent genes in Bacillus cereus by proteome and in vitro transcription analysisWillem van Schaik
Wageningen Centre for Food Sciences, Wageningen, The Netherlands
J Bacteriol 186:4100-9. 2004The alternative sigma factor sigmaB of the food pathogen Bacillus cereus is activated upon stress exposure and plays a role in the adaptive response of vegetative cells...
- InhA1, NprA, and HlyII as candidates for markers to differentiate pathogenic from nonpathogenic Bacillus cereus strainsCéline Cadot
INRA, Unité MICALIS, GME, La Minière, Guyancourt, France
J Clin Microbiol 48:1358-65. 2010b>Bacillus cereus is found in food, soil, and plants, and the ability to cause food-borne diseases and opportunistic infection presumably varies among strains...
- Identification of Bacillus cereus genes specifically expressed during growth at low temperaturesJulien Brillard
INRA, UMR408, Site Agroparc, 84914 Avignon Cedex 9, France
Appl Environ Microbiol 76:2562-73. 2010The mechanisms involved in the ability of Bacillus cereus to multiply at low temperatures were investigated. It was assumed that many genes involved in cold acclimation would be upregulated at low temperatures...
- Differentiation of Bacillus anthracis, B. cereus, and B. thuringiensis by using pulsed-field gel electrophoresisWenwan Zhong
Bioscience Division, MS M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Appl Environ Microbiol 73:3446-9. 2007..cereus and B. thuringiensis isolates by cluster analysis of the whole-genome macrorestriction enzyme digestion patterns generated by NotI...
- Analysis of acid-stressed Bacillus cereus reveals a major oxidative response and inactivation-associated radical formationMaarten Mols
Top Institute Food and Nutrition, Wageningen, The Netherlands
Environ Microbiol 12:873-85. 2010Acid stress resistance of the food-borne human pathogen Bacillus cereus may contribute to its survival in acidic environments, such as encountered in soil, food and the human gastrointestinal tract. The acid stress responses of B...
- The ExsA protein of Bacillus cereus is required for assembly of coat and exosporium onto the spore surfaceKaren Bailey-Smith
Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
J Bacteriol 187:3800-6. 2005The outermost layer of spores of the Bacillus cereus family is a loose structure known as the exosporium. Spores of a library of Tn917-LTV1 transposon insertion mutants of B...
- Mechanism of action of hemolysin III from Bacillus cereusG E Baida
Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow Region, Russia
Biochim Biophys Acta 1284:122-4. 1996b>Bacillus cereus hemolysin III activity was tested in crude extracts, from Escherichia coli carrying the hly-III gene. It was concluded that hemolysin III is a pore-forming hemolysin with functional pore diameter of about 3-3.5 nm...
- Structure of the exosporium and sublayers of spores of the Bacillus cereus family revealed by electron crystallographyDavid A Ball
Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
Mol Microbiol 68:947-58. 2008..electron microscopy and image analysis, we have characterized crystalline fragments from the exosporium of Bacillus cereus, B. thuringiensis and B. anthracis strains and identified up to three distinct crystal types...
- Prevalence and diversity of insertion sequences in the genome of Bacillus thuringiensis YBT-1520 and comparison with other Bacillus cereus group membersNing Qiu
State Key Laboratory of Agricultural Microbiology and National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University, Wuhan, Hubei, China
FEMS Microbiol Lett 310:9-16. 2010Members of the Bacillus cereus group are closely related bacteria that exhibit highly divergent pathogenic properties. Sequencing of Bacillus thuringiensis ssp...
- Response of Bacillus cereus ATCC 14579 to challenges with sublethal concentrations of enterocin AS-48María J Grande Burgos
Departamento de Ciencias de Salud Area de Microbiología, Facultad de Ciencias Experimentales, Universidad de Jaen, 23071 Jaen, Spain
BMC Microbiol 9:227. 2009..Here, we studied the effect of enterocin AS-48 challenges on vegetative cells of Bacillus cereus ATCC 14579 by use of transcriptome analysis.
- Comparative analysis of transcriptional and physiological responses of Bacillus cereus to organic and inorganic acid shocksMaarten Mols
Top Institute Food and Nutrition, Wageningen, The Netherlands Laboratory of Food Microbiology, Wageningen University and Research Centre, The Netherlands
Int J Food Microbiol 137:13-21. 2010Comparative phenotype and transcriptome analyses were performed with Bacillus cereus ATCC 14579 exposed to pH 5.5 set with different acidulants including hydrochloric acid (HCl), lactic acid (HL) and acetic acid (HAc)...
- The impact of oxygen availability on stress survival and radical formation of Bacillus cereusMaarten Mols
Top Institute Food and Nutrition, Wageningen, The Netherlands Laboratory of Food Microbiology, Wageningen University, Wageningen, The Netherlands
Int J Food Microbiol 135:303-11. 2009Both the growth and stress survival of two model Bacillus cereus strains, ATCC 14579 and ATCC 10987, were tested in three different conditions varying in oxygen availability, i.e., aerobic, microaerobic and anaerobic conditions. Both B...
- Assembly of pili on the surface of Bacillus cereus vegetative cellsJonathan M Budzik
Department of Microbiology, University of Chicago, Chicago, IL 60637, USA
Mol Microbiol 66:495-510. 2007Vegetative forms of Bacillus cereus are reported to form pili, thin protein filaments that protrude up to 1 mum from the bacterial surface...
- A strain-variable bacteriocin in Bacillus anthracis and Bacillus cereus with repeated Cys-Xaa-Xaa motifsDaniel H Haft
The J Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA
Biol Direct 4:15. 2009..cereus, but has gone unrecognized because it is always encoded far from its maturation protein operon. Patterns of insertions and deletions among twenty-four variants suggest a repeating functional unit of Cys-Xaa-Xaa...
- Bacillus cereus-induced permeability of the blood-ocular barrier during experimental endophthalmitisAndrea L Moyer
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Invest Ophthalmol Vis Sci 50:3783-93. 2009The purpose of this study was to determine to what extent blood-retinal barrier (BRB) permeability occurred during experimental Bacillus cereus endophthalmitis and whether tight junction alterations were involved in permeability.
- The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein foldA Carfi
Institut de Biologie Structurale Jean Pierre Ebel CEA CNRS, Laboratoire de Cristallographie Macromoléculaire, Grenoble, France
EMBO J 14:4914-21. 1995The 3-D structure of Bacillus cereus (569/H/9) beta-lactamase (EC 22.214.171.124), which catalyses the hydrolysis of nearly all beta-lactams, has been solved at 2...
- Comparative transcriptomic and phenotypic analysis of the responses of Bacillus cereus to various disinfectant treatmentsMara Ceragioli
Laboratory of Food Microbiology, Wageningen University, Wageningen, Netherlands
Appl Environ Microbiol 76:3352-60. 2010..In this study, the physiological and genome-wide transcriptional responses of Bacillus cereus ATCC 14579 exposed to four different disinfectants (benzalkonium chloride, sodium hypochlorite, hydrogen ..
- Phenotypic and transcriptomic analyses of mildly and severely salt-stressed Bacillus cereus ATCC 14579 cellsHeidy M W den Besten
TI Food and Nutrition, Wageningen, The Netherlands
Appl Environ Microbiol 75:4111-9. 2009..In this study, exponentially growing cells of the pathogen Bacillus cereus ATCC 14579 were exposed to both mild (2...
- The YvfTU two-component system is involved in plcR expression in Bacillus cereusJulien Brillard
UMR408, Sécurité et Qualité des Produits d Origine Végétale, INRA, Universite d Avignon, F 84000 Avignon, France
BMC Microbiol 8:183. 2008Most extracellular virulence factors produced by Bacillus cereus are regulated by the pleiotropic transcriptional activator PlcR. Among strains belonging to the B...
- Synergistic bactericidal effect of carvacrol, cinnamaldehyde or thymol and refrigeration to inhibit Bacillus cereus in carrot brothM Valero
Departamento de Producción Vegetal y Microbiología, Escuela Politecnica Superior de Orihuela, Universidad Miguel Hernandez, Campus de Orihuela, Carretera de Beniel, Km 3 2, 03312 Orihuela, Alicante, Spain
Food Microbiol 23:68-73. 2006..was studied by examining their influence in the kinetics of growth from activated spores of four Bacillus cereus strains in tyndallized carrot broth over the temperature range 5-16 degrees C...
- Bacillus cereus meningoencephalitis in preterm infants: neuroimaging characteristicsMaarten H Lequin
Department of Radiology, Sophia Children s Hospital, Erasmus MC University Medical Center, Rotterdam, The Netherlands
AJNR Am J Neuroradiol 26:2137-43. 2005..In this report we focus on the deleterious clinical course and imaging characteristics of proven Bacillus cereus meningoencephalitis.
- Purification and characterization of a solvent and detergent-stable novel protease from Bacillus cereusKiran Kumar Doddapaneni
Centre for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh, India
Microbiol Res 164:383-90. 2009..It was related to Bacillus cereus on the basis of 16S rRNA gene sequencing and biochemical properties...
- Degradation of raw feather by a novel high molecular weight extracellular protease from newly isolated Bacillus cereus DCUWAbhrajyoti Ghosh
Department of Biochemistry, University of Calcutta, 700019, West Bengal, India
J Ind Microbiol Biotechnol 35:825-34. 2008..In the present study, we have demonstrated the degradation of feather waste by Bacillus cereus DCUW strain isolated during a functional screening based microbial diversity study on East Calcutta Wetland ..
- Exploring the evolution of the Bacillus cereus group repeat element bcr1 by comparative genome analysis of closely related strainsAre Klevan
Department of Pharmaceutical Biosciences Microbiology, University of Oslo, PO Box 1068 Blindern, 0316 Oslo, Norway
Microbiology 153:3894-908. 2007bcr1 is a chromosomal approximately 155 bp repeated element found uniquely and ubiquitously in the Bacillus cereus group of Gram-positive bacteria; it exhibits several features characteristic of mobile elements, including a variable ..
- Incidence and characterization of diarrheal enterotoxins of fecal Bacillus cereus isolates associated with diarrheaMariam Saleh Al-Khatib
Department of Biological Sciences, Faculty of Science, University of Jordan, Amman 11942, Jordan
Diagn Microbiol Infect Dis 59:383-7. 2007..collected from patients with diarrhea and healthy controls without diarrhea to investigate the incidence of Bacillus cereus and its enterotoxins. B...
- Characterization of aerobic and anaerobic vegetative growth of the food-borne pathogen Bacillus cereus F4430/73 strainEric Rosenfeld
Laboraatoire de Biotechnologies et Chimie Bio organique FRE 2766 CNRS, Batiment Marie Curie, Pôle Sciences et Technologies, Universite de La Rochelle, 17042 La Rochelle Cedex 1, France
Can J Microbiol 51:149-58. 2005The Gram-positive bacterium Bacillus cereus is a facultative anaerobe that is still poorly characterized metabolically. In this study, the aerobic vegetative growth and anaerobic vegetative growth of the food-borne pathogen B...
- Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracisCliff S Han
Department of Energy Joint Genome Institute, Bioscience Division, MS M888, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
J Bacteriol 188:3382-90. 2006Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis are closely related gram-positive, spore-forming bacteria of the B. cereus sensu lato group. While independently derived strains of B...
- Structure analysis of peptide deformylase from Bacillus cereusJin Ho Moon
Biomedical Research Center, Life Sciences Division, Korea Institute of Science and Technology, Seoul, Korea
Proteins 61:217-20. 2005
- Cloning and primary structure of a new hemolysin gene from Bacillus cereusG E Baida
Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow Region, Russia
Biochim Biophys Acta 1264:151-4. 1995A new hemolysin gene from Bacillus cereus VKM-B164 was cloned in Escherichia coli and sequenced. Deduced protein consists of 219 amino acids and has a molecular mass of 24.4 kDa...
- An extracytoplasmic function sigma factor controls beta-lactamase gene expression in Bacillus anthracis and other Bacillus cereus group speciesCana L Ross
Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School, Houston, Texas 77030, USA
J Bacteriol 191:6683-93. 2009..anthracis strains to beta-lactam antibiotics is intriguing considering that the closely related species Bacillus cereus and Bacillus thuringiensis typically produce beta-lactamases and the B...
- Brain abscesses resulting from Bacillus cereus and an Aspergillus-like moldElene Psiachou-Leonard
Department of Pediatric Oncology, Hippokration Hospital, Thessaloniki, Greece
J Pediatr Hematol Oncol 24:569-71. 2002....
- Generation of thiocillin variants by prepeptide gene replacement and in vivo processing by Bacillus cereusMichael G Acker
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Chem Soc 131:17563-5. 2009....
- Proteomic analysis reveals differential protein expression by Bacillus cereus during biofilm formationMarinda C Oosthuizen
School of Molecular and Cell Biology, University of the Witwatersrand, Wits, 2050, South Africa
Appl Environ Microbiol 68:2770-80. 2002b>Bacillus cereus, a dairy-associated toxigenic bacterium, readily forms biofilms on various surfaces and was used to gain a better understanding of biofilm development by gram-positive aerobic rods. B...
- Identification and characterization of toxigenic Bacillus cereus isolates responsible for two food-poisoning outbreaksEmilia Ghelardi
Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, University of Pisa, Via San Zeno 35 39, 56127, Pisa, Italy
FEMS Microbiol Lett 208:129-34. 2002The epidemiology of Bacillus cereus strains responsible for food poisoning is scantly known, mostly because the genotypic and toxigenic properties of the B...
- CwpFM (EntFM) is a Bacillus cereus potential cell wall peptidase implicated in adhesion, biofilm formation, and virulenceSeav Ly Tran
INRA, Unité MICALIS UMR 1319, Equipe GME, La Minière, 78285 Guyancourt, France
J Bacteriol 192:2638-42. 2010b>Bacillus cereus EntFM displays an NlpC/P60 domain, characteristic of cell wall peptidases. The protein is involved in bacterial shape, motility, adhesion to epithelial cells, biofilm formation, vacuolization of macrophages, and virulence...
- Activation of PI Specific Phospholipase C EnzymesMARY FEDARKO ROBERTS; Fiscal Year: 2013..Likewise some Bacillus cereus strains are opportunistic pathogens and PI-PLC cleavage of GPI-anchored proteins is likely to contribute to ..
- Chemistry, Structure and Biology of Thiol TransferasesRichard N Armstrong; Fiscal Year: 2013..and have obtained the genes, expressed and purified the FosB enzymes from several sources including Bacillus cereus, Bacillus anthracis and Staphylococcus aureus which puts us in an excellent position to accomplish this aim...
- Interaction between B. cereus RecQ helicase and topoisomerase IIIZhiyu Li; Fiscal Year: 2010..which possess one or two type IA topoisomerases and single RecQ helicase, some Gram-positive bacteria such as Bacillus cereus and Bacillus anthracis, the etiologic agent of anthrax, encode multiple chromosomal copies of type IA ..
- Structural basis of tetracycline resistance by efflux pump TetLDANENG WANG; Fiscal Year: 2013..resistance efflux proteins (Tet) in Gram-positive bacterial pathogens, including Bacillus anthracis, Bacillus cereus, Streptococcus pneumoniae, and Staphylococcus aureus. Clostridium spp., Enterococcus spp. and Listeria spp...
- Exposporium determinants of Bacillus anthracisGeorge C Stewart; Fiscal Year: 2013..In addition, a number of endospore-forming human pathogens possess exosporia, including Bacillus cereus, Clostridium perfringens, and Clostridium difficile and a more detailed understanding of the exosporium of B...
- SURFACE PROTEIN ANCHORING IN GRAM-POSITIVE BACTERIAOlaf Schneewind; Fiscal Year: 2013..b>Bacillus cereus pili are formed from two subunits, the tip protein (BcpB) and the major pilin (BcpA), which generates the ..
- Targeting Replication-Segregation of plasmid pX01 in Bacillus anthracisDebabrata RayChaudhuri; Fiscal Year: 2010..The presence of mobile elements in pXO1 allows gene transfer to related Bacillus cereus family members...
- Surface Proteins of Bacillus anthracisOlaf Schneewind; Fiscal Year: 2013..In B. anthracis, linear PDGA strands are linked to peptidoglycan and threaded across the S-layer. Bacillus cereus G9241, which causes anthrax-like respiratory disease, elaborates a hyaluronic acid capsule;its genetic ..
- Molecular Mechanism of Cation Channel SelectivityYouxing Jiang; Fiscal Year: 2013..One is the non-selective, Ca2+ permeable cyclic nucleotide-gated (CNG) channels, using NaK from Bacillus cereus and its CNG- mimicking chimeras as model systems;the other is K+ selective channels, using a K+ selective NaK ..
- Experiment based genome mining of ribosomal natural productsBradley S Moore; Fiscal Year: 2013..characterization of ribosomally encoded toxins secreted by pathogenic bacteria such as Staphylococcus aureus, Bacillus cereus and Clostridium difficile as well as defensins produced by higher eukaryotes such as marine snails, primates ..
- Structure and Function of a Phosphorylation Coupled Saccharide TransporterMing Zhou; Fiscal Year: 2013..To this end, we have solved the structure of a ChbC ortholog from Bacillus cereus (bcChbC), which has led us to propose hypotheses for how the transporter selectively binds sugar, ..
- Biosynthetic studies on the heterocycle-containing thiopeptide natural productsLAURA CAROLINE BROWN; Fiscal Year: 2010..are: (1) To elucidate the order of post-translational modifications during thiocillin biosynthesis in Bacillus cereus. Elucidation of the mechanism of thiocillin biosynthesis will require systematic double crossover knockouts ..
- Plasmid pXO2 Replication in Bacillus anthracisSaleem Khan; Fiscal Year: 2005..Gene transfer can frequently occur between B. anthracis and closely related species such as Bacillus cereus, Bacillus thuringiensis and Bacillus mycoides, making it likely that the pXO1 and pXO2 plasmids could ..
- Escape of Bacillus anthracis from the phagsomeHoward Goldfine; Fiscal Year: 2004..Since the Ba PI-PLC ortholog is 94% identical in amino acid sequence to the PI-PLC from Bacillus cereus, it almost certainly has that enzymatic activity, but there are potential structural differences between the ..
- STRUCTURE/FUNCTION OF PI-SPECIFIC PHOSPHOLIPASE CO Griffith; Fiscal Year: 2001..e. only unphosphorylated PI is cleaved. They are secreted by the Gram plus bacteria Bacillus cereus and the nearly identical B...
- METALLOENZYMES AND ANTIBIOTIC RESISTANCE IN BACTERIARobert Shaw; Fiscal Year: 1992..This proposal describes a study of the metallo-beta-lactamases produced by the bacterium Bacillus cereus. The experimental approach is multidisciplinary in nature in that it involves the use of a combination of ..
- Phospholipid-induced Motility in Bacillus cereus GroupR Fall; Fiscal Year: 2004The goal of the proposed research is to characterize newly-discovered gliding motility in bacteria of the Bacillus cereus group. The B. cereus group, which includes pathogens of humans (B. cereus and B.anthracis) and insects (B...
- INTERFACIAL ACTIVATION OF WATER SOLUBLE PHOSPHOLIPASESMary Roberts; Fiscal Year: 2003..to understand on a molecular level the complex interfacial behavior of two water-soluble lipolytic enzymes: Bacillus cereus non-specific phospholipase C (PLC) and Streptomyces chromofuscus phospholipase D (PLD)...
- Novel Devices for Processing Bioterrorism AgentsBITA NAKHAI; Fiscal Year: 2004..A model system using Bacillus subtilis and Bacillus cereus will be employed to mimic the spores and vegetative cells of B. anthracis...
- SYNTHESIS OF NITROGEN CONTAINING NATURAL PRODUCTSStephen Martin; Fiscal Year: 2010..Secondly, the synthetic targets we have identified have significant potential as leads for the development of novel anticancer agents. ..
- Strategies for the Syntheses of Bioactive TargetsStephen Martin; Fiscal Year: 2010..Secondly, the targets we have identified have significant potential as leads for the development of novel anticancer agents having improved biological profiles. ..
- Studies of Molecular Recognition in Biological SystemsStephen Martin; Fiscal Year: 2010..Such tools are indispensable to medicinal chemists as they optimize ligand binding affinities and transform novel leads into selective and potent therapeutic agents to treat diseases. ..
- Anti-Trypanosomal Agents from a Neotropical CloudforestWILLIAM SETZER; Fiscal Year: 2004..The long-term benefit of this research project is the development of new medicines to treat patients with Chagas disease. ..
- STRATEGIES FOR INACTIVATING BACILLUS ANTHRACIS SPORESArthur Aronson; Fiscal Year: 2003..Once such reagents or methods have been identified, they will be tested on spores in various soils that should mimic natural environments and thus the conditions needed for the effective control of this bioweapon. ..
- Cloning and Engineering of Nicking enzymesShuang yong Xu; Fiscal Year: 2004..abstract_text> ..
- A universal DNA endonucleaseShuang yong Xu; Fiscal Year: 2005..For isothermal applications of the universal nuclease at 50oC-70oC, the nuclease domain will be derived from thermophilic endonucleases. ..
- Engineering DNA nicking endonucleasesShuang yong Xu; Fiscal Year: 2006..Under Phase II funding, this isothermal amplification method (NEMDA) will be optimized and the sensitivity will be improved. Finally, we will investigate the potential of NEMDA for detections of pathogens and its use in bio-prospecting. ..
- A Genetic System Able to Screen for Active DNA DemethylationShuang yong Xu; Fiscal Year: 2006..In addition, knowledge of the mechanism of demethylation could be crucial in converting fully differentiated adult stem cells into totipotent stem cells. [unreadable] [unreadable] [unreadable]..
- Measuring Metabolites using Riboswitch reportsRonald Breaker; Fiscal Year: 2006..Moreover, bioinformatics searches can be expanded to uncover examples of known or new riboswitches in humans and other eukaryotes. ..
- Identifying targets for diagnosing oral candidiasisDavid Schofield; Fiscal Year: 2005..Since Candida species are the most important fungal pathogen of the oral cavity, the rapid and accurate diagnosis of oral candidiasis using novel disease biomarkers will significantly improve oral health. ..
- ENGINEERING ALLOSTERIC RIBOZYMES AND DEOXYRIBOZYMESRonald Breaker; Fiscal Year: 2002..In addition, we will test the function of these 'molecular switches' in vivo, to establish a new method of controlled gene expression. ..
- Peptide Derivatives to treat Urinary Tract InfectionsLaszlo Otvos; Fiscal Year: 2003..Our hope is that by the end of the grant period, we will be able to provide a pyrrhocoricin-derived peptide for ensuing US Food and Drug Administration-approved preclinical and clinical evaluation against urinary tract infections. ..
- The role of C1q in regulation of monocyte to dendritic cell transitionBerhane Ghebrehiwet; Fiscal Year: 2010..G w1' 0.N ..r v0, .a. ' in the long term, may provide firm grounds for the development of innovative therapeutic intervention strategies. ..O (.) '-" .+ 4U 4.' .U- 0_0 ..
- REAL TIME DETECTION OF BACTERIA IN PLATELET CONCENTRATESBoris Rotman; Fiscal Year: 2004..Other potential applications of the bacteriologic biosensor include: diagnostics, environmental surveillance, food and beverage monitoring, and sterility testing. ..
- LOW-COST BIOSENSOR FOR REAL-TIME DIAGNOSIS OF BACTEREMIABoris Rotman; Fiscal Year: 2004..Other potential commercial applications of the bacteriologic biosensor include environmental surveillance, monitoring blood products intended for transfusion, food and beverage screening, and sterility testing. ..
- gC1q-R/p33: structure function and role on inflammation.Berhane Ghebrehiwet; Fiscal Year: 2009..abstract_text> ..
- Engineered Spores as Fluorogenic Biological Indicators for Sterility TestingBoris Rotman; Fiscal Year: 2007..To provide more rapid sterility assurance, BCR Diagnostics has developed unique living microorganisms that promptly send fluorescent light signals when the sterilization process is inadequate. [unreadable] [unreadable] [unreadable]..
- Natural mRNA Genetic Switches that Bind MetabolitesRonald Breaker; Fiscal Year: 2006..These findings will aid in the discovery of new riboswitches and will provide a solid foundation for the generation of designer genetic control elements based on RNA. ..
- LTQ Orbitrap tandem mass spectrometerCatherine Fenselau; Fiscal Year: 2007..This commercially available, technologically sophisticated instrument will support meritorious projects on a shared use, highly cost-effective basis, and foster multidisciplinary interaction. [unreadable] [unreadable] [unreadable]..