Summary: A phylum of oxygenic photosynthetic bacteria comprised of unicellular to multicellular bacteria possessing CHLOROPHYLL a and carrying out oxygenic PHOTOSYNTHESIS. Cyanobacteria are the only known organisms capable of fixing both CARBON DIOXIDE (in the presence of light) and NITROGEN. Cell morphology can include nitrogen-fixing heterocysts and/or resting cells called akinetes. Formerly called blue-green algae, cyanobacteria were traditionally treated as ALGAE.

Top Publications

  1. ncbi Environmental genome shotgun sequencing of the Sargasso Sea
    J Craig Venter
    Institute for Biological Energy Alternatives, 1901 Research Boulevard, Rockville, MD 20850, USA
    Science 304:66-74. 2004
  2. ncbi Metabolic streamlining in an open-ocean nitrogen-fixing cyanobacterium
    H James Tripp
    Ocean Sciences Department, University of California, Santa Cruz, 1156 High Street, Santa Cruz, California 95064, USA
    Nature 464:90-4. 2010
  3. ncbi Engineering cyanobacteria to generate high-value products
    Daniel C Ducat
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Trends Biotechnol 29:95-103. 2011
  4. ncbi Microbial biosynthesis of alkanes
    Andreas Schirmer
    LS9, Inc, 600 Gateway Boulevard, South San Francisco, CA 94080, USA
    Science 329:559-62. 2010
  5. pmc Ecological genomics of marine picocyanobacteria
    D J Scanlan
    Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    Microbiol Mol Biol Rev 73:249-99. 2009
  6. ncbi Photosynthesis driven conversion of carbon dioxide to fatty alcohols and hydrocarbons in cyanobacteria
    Xiaoming Tan
    Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, China
    Metab Eng 13:169-76. 2011
  7. pmc Genome fluctuations in cyanobacteria reflect evolutionary, developmental and adaptive traits
    John Larsson
    Department of Botany, Stockholm University, SE 106 09 Stockholm, Sweden
    BMC Evol Biol 11:187. 2011
  8. ncbi Emerging patterns of marine nitrogen fixation
    Jill A Sohm
    Department of Biological Sciences and Wrigley Institute for Environmental Studies, University of Southern California, Los Angeles, California 90089, USA
    Nat Rev Microbiol 9:499-508. 2011
  9. ncbi The tricarboxylic acid cycle in cyanobacteria
    Shuyi Zhang
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Science 334:1551-3. 2011
  10. ncbi Cyanobacterial photosystem II at 2.9-A resolution and the role of quinones, lipids, channels and chloride
    Albert Guskov
    Institut fur Chemie und Biochemie Kristallographie, Freie Universitat Berlin, Takustrasse 6, D 14195 Berlin, Germany
    Nat Struct Mol Biol 16:334-42. 2009

Detail Information

Publications388 found, 100 shown here

  1. ncbi Environmental genome shotgun sequencing of the Sargasso Sea
    J Craig Venter
    Institute for Biological Energy Alternatives, 1901 Research Boulevard, Rockville, MD 20850, USA
    Science 304:66-74. 2004
    ..2 million previously unknown genes represented in these samples, including more than 782 new rhodopsin-like photoreceptors. Variation in species present and stoichiometry suggests substantial oceanic microbial diversity...
  2. ncbi Metabolic streamlining in an open-ocean nitrogen-fixing cyanobacterium
    H James Tripp
    Ocean Sciences Department, University of California, Santa Cruz, 1156 High Street, Santa Cruz, California 95064, USA
    Nature 464:90-4. 2010
    Nitrogen (N(2))-fixing marine cyanobacteria are an important source of fixed inorganic nitrogen that supports oceanic primary productivity and carbon dioxide removal from the atmosphere...
  3. ncbi Engineering cyanobacteria to generate high-value products
    Daniel C Ducat
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Trends Biotechnol 29:95-103. 2011
    ..b>Cyanobacteria possess several advantages as organisms for bioindustrial processes, including simple input requirements, ..
  4. ncbi Microbial biosynthesis of alkanes
    Andreas Schirmer
    LS9, Inc, 600 Gateway Boulevard, South San Francisco, CA 94080, USA
    Science 329:559-62. 2010
    ..Here we describe the discovery of an alkane biosynthesis pathway from cyanobacteria. The pathway consists of an acyl-acyl carrier protein reductase and an aldehyde decarbonylase, which together ..
  5. pmc Ecological genomics of marine picocyanobacteria
    D J Scanlan
    Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    Microbiol Mol Biol Rev 73:249-99. 2009
  6. ncbi Photosynthesis driven conversion of carbon dioxide to fatty alcohols and hydrocarbons in cyanobacteria
    Xiaoming Tan
    Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, China
    Metab Eng 13:169-76. 2011
  7. pmc Genome fluctuations in cyanobacteria reflect evolutionary, developmental and adaptive traits
    John Larsson
    Department of Botany, Stockholm University, SE 106 09 Stockholm, Sweden
    BMC Evol Biol 11:187. 2011
    b>Cyanobacteria belong to an ancient group of photosynthetic prokaryotes with pronounced variations in their cellular differentiation strategies, physiological capacities and choice of habitat...
  8. ncbi Emerging patterns of marine nitrogen fixation
    Jill A Sohm
    Department of Biological Sciences and Wrigley Institute for Environmental Studies, University of Southern California, Los Angeles, California 90089, USA
    Nat Rev Microbiol 9:499-508. 2011
    ..However, many questions remain about marine N(2) fixation, including the role of temperature, fixed nitrogen species, CO(2) and physical forcing in controlling N(2) fixation, as well as the potential for heterotrophic N(2) fixation...
  9. ncbi The tricarboxylic acid cycle in cyanobacteria
    Shuyi Zhang
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Science 334:1551-3. 2011
    It is generally accepted that cyanobacteria have an incomplete tricarboxylic acid (TCA) cycle because they lack 2-oxoglutarate dehydrogenase and thus cannot convert 2-oxoglutarate to succinyl-coenzyme A (CoA)...
  10. ncbi Cyanobacterial photosystem II at 2.9-A resolution and the role of quinones, lipids, channels and chloride
    Albert Guskov
    Institut fur Chemie und Biochemie Kristallographie, Freie Universitat Berlin, Takustrasse 6, D 14195 Berlin, Germany
    Nat Struct Mol Biol 16:334-42. 2009
    ..The chloride position suggests a role in proton-transfer reactions because it is bound through a putative water molecule to the Mn(4)Ca cluster at a distance of 6.5 A and is close to two possible proton channels...
  11. ncbi Nitrogen fixation by marine cyanobacteria
    Jonathan P Zehr
    Department of Ocean Sciences, University of California, Santa Cruz, CA 95064, USA
    Trends Microbiol 19:162-73. 2011
    ..N(2) fixation and nitrogen (N) losses through denitrification have focused research on identifying N(2)-fixing cyanobacteria and quantifying cyanobacterial N(2) fixation...
  12. ncbi Architecture of the photosynthetic oxygen-evolving center
    Kristina N Ferreira
    Department of Biological Sciences, Imperial College London, London, SW7 2AZ, UK
    Science 303:1831-8. 2004
    ..The details of the surrounding coordination sphere of the metal cluster and the implications for a possible oxygen-evolving mechanism are discussed...
  13. ncbi Microbial ultraviolet sunscreens
    Qunjie Gao
    School of Life Sciences, Arizona State University, Tempe, Arizona 85287, USA
    Nat Rev Microbiol 9:791-802. 2011
    ..emerged as an important photoprotective mechanism in certain groups of large-celled microorganisms, such as cyanobacteria, fungi and many protists...
  14. ncbi Crystal structure of oxygen-evolving photosystem II at a resolution of 1.9 Å
    Yasufumi Umena
    Department of Chemistry, Graduate School of Science, Osaka City University, 3 3 138 Sugimoto, Sumiyoshi, Osaka 558 8585, Japan
    Nature 473:55-60. 2011
    ..The determination of the high-resolution structure of photosystem II will allow us to analyse and understand its functions in great detail...
  15. pmc Peroxiredoxins in plants and cyanobacteria
    Karl Josef Dietz
    Department of Biochemistry and Physiology of Plants, Bielefeld University, Bielefeld, Germany
    Antioxid Redox Signal 15:1129-59. 2011
    ..In plants and cyanobacteria, there exist 2-CysPrx, 1-CysPrx, PrxQ, and type II Prx...
  16. ncbi Extraordinary conservation, gene loss, and positive selection in the evolution of an ancient neurotoxin
    Shauna A Murray
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, New South Wales, Australia
    Mol Biol Evol 28:1173-82. 2011
    The recent determination of the genetic basis for the biosynthesis of the neurotoxin, saxitoxin, produced by cyanobacteria, has revealed a highly complex sequence of reactions, involving over 30 biosynthetic steps encoded by up to 26 ..
  17. ncbi Three-dimensional structure of cyanobacterial photosystem I at 2.5 A resolution
    P Jordan
    Institut für Chemie Kristallographie, Freie Universitat Berlin, D 14195 Berlin, Takustrasse 6, Germany
    Nature 411:909-17. 2001
    ..In plants, green algae and cyanobacteria, this process is driven by the cooperation of two large protein-cofactor complexes, photosystems I and II, ..
  18. ncbi Segregation of nitrogen fixation and oxygenic photosynthesis in the marine cyanobacterium Trichodesmium
    I Berman-Frank
    Environmental Biophysics and Molecular Ecology Program, Institute of Marine and Coastal Sciences, Rutgers University, 71 Dudley Road, New Brunswick, NJ 08901, USA
    Science 294:1534-7. 2001
    In the modern ocean, a significant amount of nitrogen fixation is attributed to filamentous, nonheterocystous cyanobacteria of the genus Trichodesmium...
  19. ncbi The genome of a motile marine Synechococcus
    B Palenik
    Marine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0202, USA
    Nature 424:1037-42. 2003
    Marine unicellular cyanobacteria are responsible for an estimated 20-40% of chlorophyll biomass and carbon fixation in the oceans. Here we have sequenced and analysed the 2.4-megabase genome of Synechococcus sp...
  20. pmc Diverse taxa of cyanobacteria produce beta-N-methylamino-L-alanine, a neurotoxic amino acid
    Paul Alan Cox
    Institute for Ethnomedicine, National Tropical Botanical Garden, Kalaheo, HI 96741, USA
    Proc Natl Acad Sci U S A 102:5074-8. 2005
    b>Cyanobacteria can generate molecules hazardous to human health, but production of the known cyanotoxins is taxonomically sporadic...
  21. ncbi Iron and phosphorus co-limit nitrogen fixation in the eastern tropical North Atlantic
    Matthew M Mills
    Marine Biogeochemistry, IFM GEOMAR Leibniz Institut für Meereswissenschaften, Düsternbrooker Weg 20, D 24105 Kiel, Germany
    Nature 429:292-4. 2004
    ..Our results support the hypothesis that aeolian mineral dust deposition promotes nitrogen fixation in the eastern tropical North Atlantic...
  22. pmc Heterotrophic organisms dominate nitrogen fixation in the South Pacific Gyre
    Hannah Halm
    Max Planck Institute for Marine Microbiology, Bremen, Germany
    ISME J 6:1238-49. 2012
    ..such as, Trichodesmium, but a prevalence of γ-proteobacteria and the unicellular photoheterotrophic Group A cyanobacteria. The dominance of these likely heterotrophic diazotrophs was further verified by quantitative PCR...
  23. ncbi Cyanobacterial genomics for ecology and biotechnology
    Wolfgang R Hess
    University of Freiburg, Schänzlestr 1, D 79104 Freiburg, Germany
    Curr Opin Microbiol 14:608-14. 2011
    b>Cyanobacteria are the only prokaryotes that directly convert solar energy and CO(2) into organic matter by oxygenic photosynthesis, explaining their relevance for primary production in many ecosystems and the increasing interest for ..
  24. pmc Cyanobacterial diversity in natural and artificial microbial mats of Lake Fryxell (McMurdo Dry Valleys, Antarctica): a morphological and molecular approach
    Arnaud Taton
    Laboratoire d Algologie, de Mycologie et de Systématique Expérimentale, Institut de Botanique B22, Universite de Liege, B 4000 Liege, Belgium
    Appl Environ Microbiol 69:5157-69. 2003
    Currently, there is no consensus concerning the geographic distribution and extent of endemism in Antarctic cyanobacteria. In this paper we describe the phenotypic and genotypic diversity of cyanobacteria in a field microbial mat sample ..
  25. pmc Sponge mass mortalities in a warming Mediterranean Sea: are cyanobacteria-harboring species worse off?
    Emma Cebrian
    Universitat de Girona, Facultat de Ciencies, Departament de Ciències Ambientals, Girona, Spain
    PLoS ONE 6:e20211. 2011
    ..A comparative ultrastructural study of injured and healthy I. fasciculata specimens showed that cyanobacteria disappeared from injured specimens, which suggests that cyanobacterial decay could be involved in I...
  26. ncbi Large-scale phylogenomic analyses indicate a deep origin of primary plastids within cyanobacteria
    Alexis Criscuolo
    Institut Pasteur, Departement de Microbiologie, Unite de Biologie Moleculaire du Gene chez les Extremophiles, 25 28 Rue du Dr Roux, Paris Cedex 15, France
    Mol Biol Evol 28:3019-32. 2011
    ..191 protein markers and over 30,000 aligned amino acid sites from 22 primary photosynthetic eukaryotes and 61 cyanobacteria representing a wide taxonomic sampling of this phylum...
  27. pmc Cyanobacteria produce a high variety of hepatotoxic peptides in lichen symbiosis
    Ulla Kaasalainen
    Department of Biosciences, Division of Microbiology, University of Helsinki, FIN 00014, Helsinki, Finland
    Proc Natl Acad Sci U S A 109:5886-91. 2012
    Lichens are symbiotic associations between fungi and photosynthetic algae or cyanobacteria. Microcystins are potent toxins that are responsible for the poisoning of both humans and animals...
  28. ncbi Phosphonate utilization by the globally important marine diazotroph Trichodesmium
    S T Dyhrman
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA
    Nature 439:68-71. 2006
    ..This adaptation may help to explain the prevalence of Trichodesmium in low phosphate, oligotrophic systems...
  29. ncbi Synthetic biology in cyanobacteria engineering and analyzing novel functions
    Thorsten Heidorn
    Department of Photochemistry and Molecular Science, A ngstro m Laboratories, Uppsala University, Uppsala, Sweden
    Methods Enzymol 497:539-79. 2011
    b>Cyanobacteria are the only prokaryotes capable of using sunlight as their energy, water as an electron donor, and air as a source of carbon and, for some nitrogen-fixing strains, nitrogen...
  30. ncbi Phosphorus limitation of nitrogen fixation by Trichodesmium in the central Atlantic Ocean
    S A Sañudo-Wilhelmy
    Marine Sciences Research Center, State University of New York, Stony Brook, New York 11794 5000, USA
    Nature 411:66-9. 2001
  31. pmc Inorganic carbon limitation induces transcripts encoding components of the CO(2)-concentrating mechanism in Synechococcus sp. PCC7942 through a redox-independent pathway
    Fiona J Woodger
    Molecular Plant Physiology Group, Research School of Biological Sciences, Australian National University, PO Box 475, Canberra, Australian Capital Territory 0200, Australia
    Plant Physiol 133:2069-80. 2003
    ..This approach was also used to test hypotheses about sensing of Ci limitation in cyanobacteria. The transcriptional response of Synechococcus sp...
  32. pmc Genome evolution in cyanobacteria: the stable core and the variable shell
    Tuo Shi
    Environmental Biophysics and Molecular Ecology Program, Institute of Marine and Coastal Sciences and Department of Earth and Planetary Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    Proc Natl Acad Sci U S A 105:2510-5. 2008
    b>Cyanobacteria are the only known prokaryotes capable of oxygenic photosynthesis, the evolution of which transformed the biology and geochemistry of Earth...
  33. ncbi Protein-based organelles in bacteria: carboxysomes and related microcompartments
    Todd O Yeates
    UCLA Department of Chemistry and Biochemistry, USA
    Nat Rev Microbiol 6:681-91. 2008
    ..The carboxysome, a prototypical bacterial microcompartment that is found in cyanobacteria and some chemoautotrophs, encapsulates ribulose-l,5-bisphosphate carboxylase/oxygenase (RuBisCO) and carbonic ..
  34. pmc Design and characterization of molecular tools for a Synthetic Biology approach towards developing cyanobacterial biotechnology
    Hsin Ho Huang
    Department of Photochemistry and Molecular Science, Angstrom Laboratories, Uppsala University, P O Box 523, SE 751 20 Uppsala, Sweden
    Nucleic Acids Res 38:2577-93. 2010
    b>Cyanobacteria are suitable for sustainable, solar-powered biotechnological applications...
  35. ncbi Alterations in global patterns of gene expression in Synechocystis sp. PCC 6803 in response to inorganic carbon limitation and the inactivation of ndhR, a LysR family regulator
    Hong liang Wang
    Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, Oklahoma 74075, USA
    J Biol Chem 279:5739-51. 2004
    ..We therefore suggest that ndhR be renamed ccmR to better represent its broader regulatory characteristics...
  36. pmc Prochlorococcus, a marine photosynthetic prokaryote of global significance
    F Partensky
    Station Biologique, CNRS, INSU et Université Pierre et Marie Curie, F 29680 Roscoff
    Microbiol Mol Biol Rev 63:106-27. 1999
    ..The present review critically assesses the basic knowledge acquired about Prochlorococcus both in the ocean and in the laboratory...
  37. doi Climate. Blooms like it hot
    Hans W Paerl
    Institute of Marine Sciences, University of North Carolina at Chapel Hill, Morehead City, NC 28557, USA
    Science 320:57-8. 2008
  38. ncbi Cyanobacterial toxins: risk management for health protection
    Geoffrey A Codd
    Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, Dundee DD1 4HN, UK
    Toxicol Appl Pharmacol 203:264-72. 2005
    ..Mass populations of toxin-producing cyanobacteria in natural and controlled waterbodies include blooms and scums of planktonic species, and mats and biofilms of ..
  39. ncbi CO2 concentrating mechanisms in algae: mechanisms, environmental modulation, and evolution
    Mario Giordano
    Department of Marine Sciences, Universita Politecnica delle Marche, 60121 Ancona, Italy
    Annu Rev Plant Biol 56:99-131. 2005
    ..We discuss the diversity of CCMs, their evolutionary origins, and the role of the environment in CCM modulation...
  40. ncbi Unicellular cyanobacterial distributions broaden the oceanic N2 fixation domain
    Pia H Moisander
    Department of Ocean Sciences, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA
    Science 327:1512-4. 2010
    ..We found that two major groups of unicellular N2-fixing cyanobacteria (UCYN) have distinct spatial distributions that differ from those of Trichodesmium, the N2-fixing ..
  41. ncbi Unicellular cyanobacteria fix N2 in the subtropical North Pacific Ocean
    J P Zehr
    Department of Ocean Sciences and Institute of Marine Sciences, University of California, Santa Cruz, California 95064, USA
    Nature 412:635-8. 2001
    ..Here we show that there are unicellular cyanobacteria in the open ocean that are expressing nitrogenase, and are abundant enough to potentially have a significant ..
  42. ncbi Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation
    Gabrielle Rocap
    School of Oceanography, University of Washington, Seattle, Washington 98195, USA
    Nature 424:1042-7. 2003
    ..Some of these genes have obvious roles in determining the relative fitness of the ecotypes in response to key environmental variables, and hence in regulating their distribution and abundance in the oceans...
  43. ncbi The fast and slow kinetics of chlorophyll a fluorescence induction in plants, algae and cyanobacteria: a viewpoint
    George C Papageorgiou
    National Center for Scientific Research Demokritos, Institute of Biology, Athens, 153 10, Greece
    Photosynth Res 94:275-90. 2007
    ..FI has been studied quite extensively in plants an algae (less so in cyanobacteria) as it affords a low resolution panoramic view of the photosynthesis process...
  44. ncbi Comparative microbial diversity analyses of modern marine thrombolitic mats by barcoded pyrosequencing
    Jennifer M Mobberley
    Department of Microbiology and Cell Science, University of Florida, Space Life Sciences Laboratory, Kennedy Space Center, FL 32899, USA
    Environ Microbiol 14:82-100. 2012
    ..resolution, the domain bacterial sequence libraries from the four mats were similar, with Proteobacteria and Cyanobacteria being the most abundant...
  45. ncbi Enslavement in the water body by toxic Aphanizomenon ovalisporum, inducing alkaline phosphatase in phytoplanktons
    Yehonathan Bar-Yosef
    Department of Plant and Environmental Sciences, Edmond J Safra Campus, Givat Ram, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Curr Biol 20:1557-61. 2010
    The hepatotoxin cylindrospermopsin (CYN) produced by certain cyanobacteria, including Aphanizomenon ovalisporum (hereafter Aphanizomenon) [1], seriously affects lake water quality [2], but its biological role is not known...
  46. ncbi A molecular assessment of the iron stress response in the two phylogenetic clades of Trichodesmium
    P Dreux Chappell
    MIT WHOI Joint Program in Oceanography Applied Ocean Science and Engineering, Cambridge, MA 02139, USA
    Environ Microbiol 12:13-27. 2010
    ..However the apparent conservation of the Fe stress response in the Trichodesmium genus suggests that it is an important adaptation for their niche in the oligotrophic ocean...
  47. ncbi Diurnal expression of hetR and diazocyte development in the filamentous non-heterocystous cyanobacterium Trichodesmium erythraeum
    R El-Shehawy
    Department of Botany, Stockholm University, 10691 Stockholm, Sweden
    Microbiology 149:1139-46. 2003
    ..Real-time RT-PCR showed that ntcA, encoding the global nitrogen regulator in cyanobacteria, and hetR, the key regulatory gene in heterocyst differentiation, are both constitutively expressed during a ..
  48. ncbi Salt stress inhibits photosystems II and I in cyanobacteria
    Suleyman I Allakhverdiev
    Institute of Basic Biological Problems, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia
    Photosynth Res 98:529-39. 2008
    ..In this review, we summarize recent progress in research on the effects of salt stress on photosynthesis in cyanobacteria.
  49. pmc Cyanobacteria and cyanotoxins: the influence of nitrogen versus phosphorus
    Andrew M Dolman
    Freshwater Conservation, Brandenburg University of Technology, Bad Saarow, Germany
    PLoS ONE 7:e38757. 2012
    ..While the positive relationship between total cyanobacteria biovolume and P concentration disappeared at high P concentrations, cyanobacteria biovolume increased ..
  50. pmc Renewable energy from Cyanobacteria: energy production optimization by metabolic pathway engineering
    Naira Quintana
    Division of Pharmacognosy, Section of Metabolomics, Institute of Biology, Leiden University, PO Box 9502, 2300RA Leiden, The Netherlands
    Appl Microbiol Biotechnol 91:471-90. 2011
    ..paper deals with a third generation renewable energy resource which does not compete with our food resources, cyanobacteria. We discuss the current state of the art in developing different types of bioenergy (ethanol, biodiesel, ..
  51. ncbi High rates of photobiological H2 production by a cyanobacterium under aerobic conditions
    Anindita Bandyopadhyay
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Nat Commun 1:139. 2010
  52. pmc Genome erosion in a nitrogen-fixing vertically transmitted endosymbiotic multicellular cyanobacterium
    Liang Ran
    Department of Botany, Stockholm University, Stockholm, Sweden
    PLoS ONE 5:e11486. 2010
    ..The underlying mechanism and the identities of the partners in this monophyletic event remain elusive...
  53. ncbi Colourful coexistence of red and green picocyanobacteria in lakes and seas
    Maayke Stomp
    Aquatic Microbiology, Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Nieuwe Achtergracht 127, 1018 WS Amsterdam, The Netherlands
    Ecol Lett 10:290-8. 2007
    ..These field data support the hypothesis that niche differentiation along the light spectrum promotes phytoplankton biodiversity, thus providing a colourful solution to the paradox of the plankton...
  54. pmc Genome mining demonstrates the widespread occurrence of gene clusters encoding bacteriocins in cyanobacteria
    Hao Wang
    Division of Microbiology, Department of Food and Environment Sciences, University of Helsinki, Helsinki, Finland
    PLoS ONE 6:e22384. 2011
    b>Cyanobacteria are a rich source of natural products with interesting biological activities. Many of these are peptides and the end products of a non-ribosomal pathway...
  55. pmc Biologically active secondary metabolites from marine cyanobacteria
    Joshawna K Nunnery
    Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA
    Curr Opin Biotechnol 21:787-93. 2010
    Marine cyanobacteria are a rich source of complex bioactive secondary metabolites which derive from mixed biosynthetic pathways...
  56. ncbi Discovery of symbiotic nitrogen-fixing cyanobacteria in corals
    Michael P Lesser
    Department of Zoology and Center for Marine Biology, University of New Hampshire, Durham, NH 03824, USA
    Science 305:997-1000. 2004
    ..The source of this fluorescence is phycoerythrin in unicellular, nonheterocystis, symbiotic cyanobacteria within the host cells of the coral...
  57. ncbi Aquatic phototrophs: efficient alternatives to land-based crops for biofuels
    G Charles Dismukes
    Department of Chemistry and Princeton Environmental Institute, Princeton University, Princeton, NJ 08544, USA
    Curr Opin Biotechnol 19:235-40. 2008
    ..the use of biofuels derived from aquatic microbial oxygenic photoautotrophs (AMOPs), more commonly known as cyanobacteria, algae, and diatoms...
  58. ncbi Lagunamides A and B: cytotoxic and antimalarial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula
    Ashootosh Tripathi
    Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore 637616, Singapore
    J Nat Prod 73:1810-4. 2010
    ..4 and 20.5 nM, respectively. Furthermore, these cyanobacterial compounds exhibited moderate antiswarming activities when tested against Pseudomonas aeruginosa PA01...
  59. pmc Chlorophyll fluorescence analysis of cyanobacterial photosynthesis and acclimation
    D Campbell
    Department of Biology, Mount Allison University, Sackville, New Brunswick E4L 1G7, Canada
    Microbiol Mol Biol Rev 62:667-83. 1998
    b>Cyanobacteria are ecologically important photosynthetic prokaryotes that also serve as popular model organisms for studies of photosynthesis and gene regulation...
  60. ncbi Geographical isolation in hot spring cyanobacteria
    R Thane Papke
    Department of Microbiology, 109 Lewis Hall, Montana State University, Bozeman, MT 59717, USA
    Environ Microbiol 5:650-9. 2003
    ..The genetic diversity of cyanobacteria indigenous to North American, Japanese, New Zealand and Italian springs was surveyed by (i) amplification and ..
  61. pmc Differential gene retention in plastids of common recent origin
    Adrian Reyes-Prieto
    Department of Ecology, Evolution and Natural Resources, Rutgers University, NJ, USA
    Mol Biol Evol 27:1530-7. 2010
    ..Our study demonstrates that plastid genomes in sister taxa are strongly constrained by selection but follow distinct trajectories during the earlier phases of organelle evolution...
  62. pmc Use of degenerate oligonucleotides for amplification of the nifH gene from the marine cyanobacterium Trichodesmium thiebautii
    J P Zehr
    New England Biolabs, Inc, Beverly, Massachusetts 01915
    Appl Environ Microbiol 55:2522-6. 1989
    Trichodesmium spp. are marine filamentous, nonheterocystous, nitrogen-fixing cyanobacteria which are an important component of marine ecosystems...
  63. pmc Diurnal rhythms result in significant changes in the cellular protein complement in the cyanobacterium Cyanothece 51142
    Jana Stöckel
    Department of Biology, Washington University, St Louis, Missouri, United States of America
    PLoS ONE 6:e16680. 2011
    ..This analysis is the first comprehensive report on global quantitative proteomics in a unicellular diazotrophic cyanobacterium and uncovers novel findings about diurnal rhythms...
  64. ncbi Iron limitation in the marine cyanobacterium Trichodesmium reveals new insights into regulation of photosynthesis and nitrogen fixation
    Hendrik Küpper
    Universitat Konstanz, Mathematisch Naturwissenschaftliche Sektion, Fachbereich Biologie, D 78457 Konstanz, Germany
    New Phytol 179:784-98. 2008
    ..Trichodesmium survives short-term Fe limitation by selectively down-regulating nitrogen fixation while maintaining but re-arranging the photosynthetic apparatus...
  65. pmc Nitrogen fixation and hydrogen metabolism in cyanobacteria
    Hermann Bothe
    Botanical Institute, The University of Cologne, Zülpicher Str 47b, D 50923 Cologne, Germany
    Microbiol Mol Biol Rev 74:529-51. 2010
    This review summarizes recent aspects of (di)nitrogen fixation and (di)hydrogen metabolism, with emphasis on cyanobacteria. These organisms possess several types of the enzyme complexes catalyzing N(2) fixation and/or H(2) formation or ..
  66. pmc Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam
    Paul Alan Cox
    Institute for Ethnobotany, National Tropical Botanical Garden, Kalaheo, HI 96741, USA
    Proc Natl Acad Sci U S A 100:13380-3. 2003
    ..Free-living cyanobacteria produce 0.3 microg/g BMAA, but produce 2-37 microg/g as symbionts in the coralloid roots of cycad trees...
  67. ncbi Combined exposure to hydrogen peroxide and light--selective effects on cyanobacteria, green algae, and diatoms
    Michaela Drábková
    Department of Aquatic Ecology and Ecotoxicology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Environ Sci Technol 41:309-14. 2007 develop a potential tool for limiting cyanobacterial blooms and to better understand the occurrence of cyanobacteria and other phytoplankton species in relation to reactive oxygen species in surface waters...
  68. pmc The smallest known genomes of multicellular and toxic cyanobacteria: comparison, minimal gene sets for linked traits and the evolutionary implications
    Karina Stucken
    Alfred Wegener Institute for Polar and Marine Research, Bremerhaven, Germany
    PLoS ONE 5:e9235. 2010
    ..9 (CS-505) and 3.2 (D9) Mb, these are the smallest genomes described for free-living filamentous cyanobacteria. We observed remarkable gene order conservation (synteny) between these genomes despite the difference in ..
  69. ncbi The high light-inducible polypeptides in Synechocystis PCC6803. Expression and function in high light
    Q He
    Department of Plant Biology, The Carnegie Institution of Washington, Stanford, California 94305, USA
    J Biol Chem 276:306-14. 2001
    ..Hence, the Hli polypeptides are critical for survival when Synechocystis PCC6803 is absorbing excess excitation energy and may allow the cells to cope more effectively with the production of reactive oxygen species...
  70. pmc Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina
    Wesley D Swingley
    Institute of Low Temperature Science, Hokkaido University, N19W8, Sapporo 060 0819, Japan
    Proc Natl Acad Sci U S A 105:2005-10. 2008
    ..These features clearly show that the genus Acaryochloris is a fitting candidate for understanding genome expansion, gene acquisition, ecological adaptation, and photosystem modification in the cyanobacteria.
  71. pmc Biosynthetic origin of natural products isolated from marine microorganism-invertebrate assemblages
    T Luke Simmons
    Scripps Institution of Oceanography, Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093
    Proc Natl Acad Sci U S A 105:4587-94. 2008
    ..Examples are given from the literature as well as recent proof-of-concept experiments from the authors' laboratories...
  72. ncbi High rates of N2 fixation by unicellular diazotrophs in the oligotrophic Pacific Ocean
    Joseph P Montoya
    School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Nature 430:1027-32. 2004
    ..Large colonial cyanobacteria in the genus Trichodesmium and the heterocystous endosymbiont Richelia have traditionally been considered the ..
  73. ncbi Diversity of phototrophic bacteria in microbial mats from Arctic hot springs (Greenland)
    Guus Roeselers
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, NL 2628 BC Delft, The Netherlands
    Environ Microbiol 9:26-38. 2007
    ..Specific oligonucleotide primers for cyanobacteria, purple sulfur bacteria, green sulfur bacteria and Choroflexus/Roseiflexus-like green non-sulfur bacteria were ..
  74. ncbi Engineered cyanobacteria: teaching an old bug new tricks
    Anne M Ruffing
    Sandia National Laboratories, Albuquerque, NM, USA
    Bioeng Bugs 2:136-49. 2011
    b>Cyanobacteria have played an important role in the development of the Earth and have long been studied as model organisms for photosynthesis and the circadian rhythm...
  75. ncbi Genetic tools for cyanobacteria
    O A Koksharova
    MSU DOE Plant Research Laboratory, Michigan State University, East Lansing 48824, USA
    Appl Microbiol Biotechnol 58:123-37. 2002
    b>Cyanobacteria are oxygenic photosynthetic bacteria that have been used increasingly to study diverse biological processes, including photosynthesis and its regulation; cell differentiation and N2 fixation; metabolism of nitrogen, carbon, ..
  76. ncbi Colorful niches of phototrophic microorganisms shaped by vibrations of the water molecule
    Maayke Stomp
    Aquatic Microbiology, Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands
    ISME J 1:271-82. 2007
    ..This suggests that vibrations of the water molecule have played a major role in the ecology and evolution of phototrophic microorganisms...
  77. ncbi Carotenoids provide the major antioxidant defence in the globally significant N2-fixing marine cyanobacterium Trichodesmium
    Dovi Kelman
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Environ Microbiol 11:1897-908. 2009
    ..We examined total antioxidative potential of various diazotrophic and non-diazotrophic cyanobacteria. We focused on Trichodesmium spp...
  78. ncbi Effects of amino acids on microcystin production of the Microcystis aeruginosa
    Ruihua Dai
    State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    J Hazard Mater 161:730-6. 2009
    ..Our experiment demonstrated that the possible reason of such phenomenon was that different amino acids had different effects on the process of metabolism through the free dissolved amino acids within the cells...
  79. pmc Optimization of variable fluorescence measurements of phytoplankton communities with cyanobacteria
    Stefan G H Simis
    Finnish Environment Institute SYKE, Marine Research Centre, Erik Palménin aukio 1, 00560 Helsinki, Finland
    Photosynth Res 112:13-30. 2012
    ..fluorescence matrices of phytoplankton communities were simulated from laboratory-grown algae and cyanobacteria cultures, to define the optical configurations of theoretical fluorometers that either minimize or maximize ..
  80. pmc Marine benthic cyanobacteria contain apoptosis-inducing activity synergizing with daunorubicin to kill leukemia cells, but not cardiomyocytes
    Linn Oftedal
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Mar Drugs 8:2659-72. 2010
    The potential of marine benthic cyanobacteria as a source of anticancer drug candidates was assessed in a screen for induction of cell death (apoptosis) in acute myeloid leukemia (AML) cells...
  81. pmc Distribution and activity of diazotrophs in the Eastern Equatorial Atlantic
    Rachel A Foster
    Ocean Sciences, University of California, Santa Cruz, CA 95064, USA
    Environ Microbiol 11:741-50. 2009
    ..The distribution of the diazotroph groups, especially the three strains of symbiotic cyanobacteria, was different, and appeared largely controlled by riverine inputs and upwelling.
  82. ncbi The orange carotenoid protein in photoprotection of photosystem II in cyanobacteria
    Diana Kirilovsky
    Commissariat a l Energie Atomique CEA, Institut de Biologie et Technologies de Saclay iBiTec S, France
    Biochim Biophys Acta 1817:158-66. 2012
    ..In this review we describe results leading to the discovery of this process in cyanobacteria (qE(cya)), which is mechanistically distinct from its counterpart in plants, and recent progress in the ..
  83. ncbi Regulation of nitrate assimilation in cyanobacteria
    Yoshitake Ohashi
    Graduate School of Bioagricultural Sciences, Nagoya University, Furo, Chikusa, Nagoya 464 8601, Japan
    J Exp Bot 62:1411-24. 2011
    Nitrate assimilation by cyanobacteria is inhibited by the presence of ammonium in the growth medium. Both nitrate uptake and transcription of the nitrate assimilatory genes are regulated...
  84. ncbi Unicellular cyanobacterium symbiotic with a single-celled eukaryotic alga
    Anne W Thompson
    Ocean Sciences, University of California, Santa Cruz, CA 95064, USA
    Science 337:1546-50. 2012
  85. ncbi Comparative study of microcystin-LR-induced behavioral changes of two fish species, Danio rerio and Leucaspius delineatus
    Daniela Baganz
    Leibniz Institute of Freshwater Ecology and Inland Fisheries, Biogeochemical Regulation, Muggelseedamm 301, 12587 Berlin, Germany
    Environ Toxicol 19:564-70. 2004
  86. ncbi Variation in the response of juvenile and adult gastropods (Lymnaea stagnalis) to cyanobacterial toxin (microcystin-LR)
    Claudia Gerard
    UMR Ecobio 6553, Equipe de Physiologie et Ecophysiologie, Universite de Rennes I, Campus de Beaulieu, Avenue du General Leclerc, 35042 Rennes Cedex, France
    Environ Toxicol 20:592-6. 2005
    Owing to the increasing public health problem related to the proliferation of toxin-producing cyanobacteria in aquatic ecosystems, we have investigated the response of the pond snail Lymnaea stagnalis exposed to 33 microg/L microcystin-..
  87. ncbi Horizontal gene transfer in cyanobacterial signature genes
    Shailaja Yerrapragada
    Human Genome Sequencing Center Baylor College of Medicine, Houston, Texas, USA
    Methods Mol Biol 532:339-66. 2009
    ..diverse cyanobacterial genomes identified an updated list of 183 signature genes that are widely found in cyanobacteria but absent in non-cyanobacterial species...
  88. ncbi Detection of the neurotoxin BMAA within cyanobacteria isolated from freshwater in China
    Aifeng Li
    Key Laboratory of Marine Environmental Sciences and Ecology, Ocean University of China, Qingdao 266100, PR China
    Toxicon 55:947-53. 2010
    ..BMAA was detected within the majority of cyanobacterial isolates surveyed in both free and symbiotic cyanobacteria, living in freshwater as well as marine environments...
  89. ncbi Compartmentalized function through cell differentiation in filamentous cyanobacteria
    Enrique Flores
    Instituto de Bioqumica Vegetal y Fotosntesis, CSIC and Universidad de Sevilla, Amrico Vespucio 49, E41092 Seville, Spain
    Nat Rev Microbiol 8:39-50. 2010
    Within the wide biodiversity that is found in the bacterial world, Cyanobacteria represents a unique phylogenetic group that is responsible for a key metabolic process in the biosphere - oxygenic photosynthesis - and that includes ..
  90. ncbi 2,2'-beta-hydroxylase (CrtG) is involved in carotenogenesis of both nostoxanthin and 2-hydroxymyxol 2'-fucoside in Thermosynechococcus elongatus strain BP-1
    Masako Iwai
    Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Yamazaki, Noda, Chiba, 278 8510, Japan
    Plant Cell Physiol 49:1678-87. 2008
    ..Ketocarotenoids, such as echinenone and 4-ketomyxol, which are unique carotenoids in cyanobacteria, were absent, and genes coding for both beta-carotene ketolases, crtO and crtW, were absent in the genome...
  91. pmc Temporal variations in the dynamics of potentially microcystin-producing strains in a bloom-forming Planktothrix agardhii (Cyanobacterium) population
    Enora Briand
    MNHN, USM505 EA4105 Ecosystèmes et interactions toxiques, 57 rue Cuvier, case 39, 75231 Paris Cedex 05, France
    Appl Environ Microbiol 74:3839-48. 2008
    ..of these two subpopulations, we performed a 2-year survey of a perennial bloom of Planktothrix agardhii (cyanobacteria)...
  92. ncbi Toxicology and detection methods of the alkaloid neurotoxin produced by cyanobacteria, anatoxin-a
    Joana Osswald
    Interdisciplinary Centre of Marine and Environmental Research CIIMAR, Rua dos Bragas, 289, 4050 123 Porto, Portugal
    Environ Int 33:1070-89. 2007
    ..One of the consequences is the proliferation of cyanobacteria, microphytoplankton organisms that are capable to produce toxins called cyanotoxins...
  93. pmc Visualizing the spatial distribution of secondary metabolites produced by marine cyanobacteria and sponges via MALDI-TOF imaging
    Eduardo Esquenazi
    Department of Biology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Mol Biosyst 4:562-70. 2008
    Marine cyanobacteria and sponges are prolific sources of natural products with therapeutic applications...
  94. ncbi Accumulation of free and covalently bound microcystins in tissues of Lymnaea stagnalis (Gastropoda) following toxic cyanobacteria or dissolved microcystin-LR exposure
    Emilie Lance
    UMR CNRS Ecobio 6553, University of Rennes 1, Campus de Beaulieu, 265 Avenue du Général Leclerc, 35042 Rennes Cedex, France
    Environ Pollut 158:674-80. 2010
    ..7 to 66.7% were bound. After depuration, up to 15.3 microg g(-1) DW of bound MCs were detected in snails previously exposed to toxic cyanobacteria, representing a potential source of MCs transfer through the food web.
  95. ncbi Is the 16S-23S rRNA internal transcribed spacer region a good tool for use in molecular systematics and population genetics? A case study in cyanobacteria
    S L Boyer
    Department of Biology, John Carroll University, 20700 North Park Boulevard, University Heights, OH 44118, USA
    Mol Biol Evol 18:1057-69. 2001
    ..We review current knowledge of the numbers and kinds of 16S-23S ITS regions present across bacterial groups and plastids, and we discuss broad patterns congruent with higher-level systematics of prokaryotes...
  96. ncbi Characterization of cyanobacterial carotenoid ketolase CrtW and hydroxylase CrtR by complementation analysis in Escherichia coli
    Takuya Makino
    School of Fisheries Sciences, Kitasato University, Sanriku cho, Ofunato, 022 0101 Japan
    Plant Cell Physiol 49:1867-78. 2008
    ..b>Cyanobacteria are known to utilize the carotenoid ketolase CrtW and/or CrtO, and the carotenoid hydroxylase CrtR...
  97. pmc Temporal patterns of nitrogenase gene (nifH) expression in the oligotrophic North Pacific Ocean
    Matthew J Church
    Department of Oceanography, University of Hawaii, Honolulu, HI 96822, USA
    Appl Environ Microbiol 71:5362-70. 2005
    ..Five of the nifH phylotypes grouped with sequences from unicellular and filamentous cyanobacteria, and one of the phylotypes clustered with gamma-proteobacteria...
  98. pmc The photorespiratory glycolate metabolism is essential for cyanobacteria and might have been conveyed endosymbiontically to plants
    Marion Eisenhut
    Institut für Biowissenschaften, Pflanzenphysiologie, Universitat Rostock, Albert Einstein Strasse 3, 18051 Rostock, Germany
    Proc Natl Acad Sci U S A 105:17199-204. 2008
    ..2PG) metabolism is essential for photosynthesis in higher plants but thought to be superfluous in cyanobacteria because of their ability to concentrate CO(2) internally and thereby inhibit photorespiration...
  99. pmc Increased production of zeaxanthin and other pigments by application of genetic engineering techniques to Synechocystis sp. strain PCC 6803
    D Lagarde
    Thallia Pharmaceuticals S A L Orée d Ecully, 69132 Ecully cedex, France
    Appl Environ Microbiol 66:64-72. 2000
    ..In this way, by a combination of overexpression and deletion of particular genes, the carotenoid content of cyanobacteria can be altered significantly.
  100. pmc Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure
    Sara Jonasson
    Departments of Botany and Analytical Chemistry, Stockholm University, 10691 Stockholm, Sweden
    Proc Natl Acad Sci U S A 107:9252-7. 2010
    beta-methylamino-L-alanine (BMAA), a neurotoxic nonprotein amino acid produced by most cyanobacteria, has been proposed to be the causative agent of devastating neurodegenerative diseases on the island of Guam in the Pacific Ocean...
  101. pmc Human fatalities from cyanobacteria: chemical and biological evidence for cyanotoxins
    W W Carmichael
    Department of Biological Sciences, Wright State University, 3640 Colonel Glen Highway, Dayton, OH 45435, USA
    Environ Health Perspect 109:663-8. 2001
    ..5 microg/L microcystin was in the water used for dialysis treatments. This is 19.5 times the level set as a guideline for safe drinking water supplies by the World Health Organization...

Research Grants63

    Jacob McDonald; Fiscal Year: 2013
    ..BMAA is produced by all known groups of cyanobacteria (blue-green algae), including symbiotic and free-living cyanobacteria present in terrestrial, freshwater, ..
  2. Problems in Membrane Protein Crystallography: Hetero-Oligomeric Cytochrome b6f
    William A Cramer; Fiscal Year: 2012
    ..b6f complex cannot be isolated from transformable unicellular cyanobacteria because the b6f dimer is monomerized and rendered inactive and non-crystallizable upon extraction from the ..
    Jacob McDonald; Fiscal Year: 2012
    ..There is no ADME data in the literature for DMDEE. Therefore, the ADME of this is investigated in the current contract in rodents with special attention to the formation of carcinogenic metabolite N-nitrosomorpholine. ..
    Kenneth J Rothschild; Fiscal Year: 2010
    ..SRI and SRII from archaebacteria, which control phototaxis, Anabaena sensory rhodopsin (ASR) from freshwater cyanobacteria, which functions as photochromic sensors, some forms of proteorhodopsin (PR) found in marine bacteria, which ..
  5. Circadian Programs in Bacteria
    Carl Hirschie Johnson; Fiscal Year: 2013
    ..the basic principles of circadian clocks at a biophysical/molecular level in a model system, the prokaryotic cyanobacteria, where genetic/biochemical studies have identified three key clock proteins, KaiA, KaiB, and KaiC...
  6. Linking Limnology to Cyanotoxins in Drinking Water Using Buoy Sensors and Auto-Sa
    Todd R Miller; Fiscal Year: 2013
    DESCRIPTION (provided by applicant) The number of lakes supporting accumulations of toxic cyanobacteria in the United States is rising due to changes in land use and climate...
  7. 2010 Oceans and Human Health Gordon Research Conference
    EDWARD ALLEN LAWS; Fiscal Year: 2010
    ..Practical Applications of "Omics" (R)evolution in Seafood Safety Oceans and Human Health International Cyanobacteria Oceans in a Warmer World Broader Impacts Through formal presentations, poster sessions and informal ..
  8. The Molecular Mechanism of PDF Signaling to the Drosophila Circadian Clock
    ADAM C SELUZICKI; Fiscal Year: 2011
    ..rhythms are daily molecular oscillations that strongly influence physiology and behavior in organisms from cyanobacteria to humans...
  9. Neurotoxins from Marine Algae and Cyanobacteria
    Thomas F Murray; Fiscal Year: 2013
    ..Marine cyanobacteria are exceptionally rich in diverse natural product structures, many of which are toxic or have other biological ..
  10. ICBG: "Training, Conservation and Drug Discovery using Panamanian Microorganisms
    William H Gerwick; Fiscal Year: 2013 reach these goals are: 1) Use ecological concepts to guide the collection and culture of endophytic fungi, cyanobacteria and other heterotrophic bacteria within the biodiversity-rich country of Panama, 2) Produce extracts of these ..
  11. Structural Biology of the S. elongatus Circadian Clock
    Martin Egli; Fiscal Year: 2013
    ..The endogenous circadian system in cyanobacteria exerts pervasive control over cellular processes including global gene expression...
  12. Studies of redox-active sites in Photosystem II
    Victor S Batista; Fiscal Year: 2010
    ..metalloprotein complex found in the thylakoid membrane of green-plant chloroplasts and internal membranes of cyanobacteria. PSII establishes the membrane pH-gradient necessary for ATP synthesis, producing dioxygen by oxidation of ..
    Deborah Bell Pedersen; Fiscal Year: 2010
    ..and biochemical properties, raising the possibility that common mechanisms underlie all circadian clocks from cyanobacteria to humans...
  14. Development of novel detection and prediction algorithms for Microcystis blooms
    Timothy Moore; Fiscal Year: 2013
    ..b>Cyanobacteria-dominated HABs currently pose a serious health and economic risk to inhabitants and users of the Great Lakes, ..
  15. Circadian gating of cell division by the cyanobacterial oscillator
    JOSEPH A POGLIANO; Fiscal Year: 2013
    ..project will reveal how and why a circadian clock controls cell division, a coupling of timing circuits that occurs in mammalian cells as well as in cyanobacteria, and will provide novel insight into how cells inherit a sense of time.
  16. Design Principals of Photobiological Metabolism
    Daniel C Ducat; Fiscal Year: 2012
    ..These experiments will result in the construction of strains of cyanobacteria capable of producing hydrogen gas directly from sunlight...
  17. Regulation of akinete differentiation in Nostoc punctiforme
    Michael L Summers; Fiscal Year: 2013
    ..Related cyanobacteria cause toxic blooms in water systems and persist in the environment as akinetes...
    Susan S Golden; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cells of diverse organisms, from cyanobacteria to humans, execute temporal programs of physiological processes that are driven by endogenous timing mechanisms...
  19. Molecular Mechanisms of Phytochrome Signaling
    JOHN CLARK LAGARIAS; Fiscal Year: 2013
    ..By examining phytochromes from evolutionarily distant species ranging from cyanobacteria to plants, our studies seek to elucidate the basis of light sensing and the intramolecular structural changes ..
  20. The FRH DEXH box helicase: analysis of a core component of the Neurospora circadi
    Jennifer Hurley; Fiscal Year: 2012 the biochemical, physiological or behavioral processes of living entities and are present from animals to cyanobacteria. A circadian rhythm is defined as a cycle that has a period of about a single day, can persist in the absence ..
  21. Novel Targeted Anticancer Agents from Marine Cyanobacteria
    Hendrik Luesch; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cyanobacteria are among the most ancient organisms on Earth and have evolved chemical weapons for defensive purposes, which we are exploiting for anticancer drug discovery...
  22. Huntington's Disease Natural Product Drug Discovery
    Albert R La Spada; Fiscal Year: 2012
    ..b>Cyanobacteria algal marine natural product compounds are a rich source of potent drug molecules with unique structural ..
  23. Chemistry and Biology of Largazoles
    Hendrik Luesch; Fiscal Year: 2012
    ..We recently discovered largazole during our ongoing program to find novel antitumor drugs from marine cyanobacteria. Our preliminary data indicate that largazole is a potent histone deacetylase (HDAC) inhibitor...
  24. Assembly of Cyanobacterial Carboxysomes
    Myat T Lin; Fiscal Year: 2013
    ..Carboxysomes from cyanobacteria and chemoauxotrophs are the most well known bacterial microcompartments...
  25. Biosynthetic Analysis of Marine Cyanobacterial Pathways
    Janet L Smith; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Marine cyanobacteria are extraordinarily rich in their production of biologically active and structurally unique natural products...
  26. Development of novel toxin detection methodologies applicable tomarine and fresh
    Judy Westrick; Fiscal Year: 2013
    ..objectives: 1) Develop MqPCR specific TaqMan primers and probes for the detection of anatoxin-a producing cyanobacteria as well as toxic eugleniods to incorporate into the existing MqPCR method...
  27. Tropical Disease Drug Discovery from Marine Cyanobacteria in Panama
    Marcy J Balunas; Fiscal Year: 2011
    ..These new active compounds from marine cyanobacteria may also provide increased efficacy, ability to overcome resistance, and/or reduced side effects as compared ..
  28. Structure of Circadian Clock Complexes from Cyanobacteria by Three Dimensional EM
    Phoebe L Stewart; Fiscal Year: 2010
    ..The simplest cells that are known to exhibit circadian phenomena are the prokaryotic cyanobacteria. Genetic and biochemical studies have identified three key clock proteins, KaiA, KaiB, and KaiC in the ..
  29. The mechanism of signal transduction in photoreceptors
    Hartmut Luecke; Fiscal Year: 2006
    ..retinylidene proteins found in phylogenetically diverse microorganisms, including haloarchaea, proteobacteria, cyanobacteria, fungi, and algae...
  30. An Accurate Mass TOF Mass Spectrometer - HPLC System for Marine Organic Chemistry
    William Fenical; Fiscal Year: 2012
    ..novel marine natural products, efficient "dereplication" of known natural products from marine bacteria and cyanobacteria, identification of microbial metabolites in low concentrations following genetic manipulation, and structure ..
  31. Cyano-Map: Linking cyanobacteria metrics and human health
    Nathan Torbick; Fiscal Year: 2012
    ..applicant): Research at the intersection of limnology and public health is showing that toxins produced from cyanobacteria act as an environmental trigger for Amyotrophic Lateral Sclerosis (ALS) commonly known as Lou Gehrig's ..
  32. Evaluation of athero-protective role of blue-green algae
    Ji Young Lee; Fiscal Year: 2010
  33. Engineering hybrid polyketide synthase systems using high affinity DNA binding do
    JOSEPH ANTHONY CHEMLER; Fiscal Year: 2012
    ..g. actinomycetes, marine cyanobacteria, myxobacteria) can interact more productively if engaged through a strong binding interface...
  34. Discovery of Anticancer Agents of Diverse Natural Orgin
    ALAN DOUGLAS KINGHORN; Fiscal Year: 2011 established botanists located in tropical countries with the assistance of the NAPRALERT database, and cyanobacteria and filamentous fungi will also be accessed...
  35. Synthetic Models of the Oxygen Evolving Complex of Photosystem II
    Theodor Agapie; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Biological dioxygen generation occurs within Photosystem II (PSII) in cyanobacteria and plants...
  36. Pilot-Scale Libraries of Marine Cyanobacterial Natural Products
    VALERIE JEAN PAUL; Fiscal Year: 2010
    b>Cyanobacteria are among the most ancient organisms on Earth and their ubiquitous presence to this day in terrestrial, freshwater and marine environments is indication for their success in competitive situations...
    Richard Moore; Fiscal Year: 2002
    The long term goal of this research is to discover new antitumor drugs from blue-green algae (cyanobacteria)...
  38. Mapping the Secondary Metabolomes of Marine Cyanobacteria
    William H Gerwick; Fiscal Year: 2013
    ..technologies to evaluate the degree of expression of natural product pathways in our cultured marine cyanobacteria, and to connect Natural Product Super-producing strains of cyanobacteria with their genotypes...
  39. Discovery of Anticancer Drugs from Cyanophytes
    ..of new anticancer drugs with solid tumor selectivity from leads obtained from collected and cultured marine cyanobacteria and marine microalgae...
  40. The properties and evolvability of the cyanobacterial circadian genetic network
    Ryan K Shultzaberger; Fiscal Year: 2013
    ..I will probe the properties and evolution of the genetic network that underlies circadian rhythm in the cyanobacteria Synechococcus elongatus PCC 7942 to better understand the molecular mechanism of circadian regulation, its ..
    Arthur Grossman; Fiscal Year: 1992
    ..the expression of genes encoding the components of the phycobilisome, the major light- harvesting complex in cyanobacteria and red algae...
  42. Zebrafish Embryos as a Model for Cyanobacterial Toxins
    John Berry; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Cyanobacteria, or "blue-green algae," particularly in freshwater habitats, are recognized to produce an array of potently toxic compounds...
    MARTHA TEETER; Fiscal Year: 1993
    ..We will solve the crystal structure of one of the small proteins (5000 MW) and progress to larger, more complex structures (10,000 and 17,5090 MW)...
  44. Validation of Fumonisin and Microcystin Biomarkers
    Jia Sheng Wang; Fiscal Year: 2003
    ..and microcystins are newly identified environmental biotoxins that are produced by toxicogenic fungi and cyanobacteria, respectively...
    Parag Chitnis; Fiscal Year: 1999 a heteromultimeric pigment-protein complex in the photo synthetic membranes of chloroplasts and cyanobacteria. It contains at least eleven proteins, 100 chlorophylls, beta-carotenes and a series of electron transfer ..
    Gunda Georg; Fiscal Year: 2001
    ..Suitable candidates will be selected and used to study the ligand-protein interactions in fluorescent, photoaffinity and electrophilic labeling studies. ..
  47. Coupling between Circadian Rhythms and Metaboilsm in Cyanobacteria
    MICHAEL RUST; Fiscal Year: 2013
    ..In Aim 3, we will determine the impact of misalignment between the clock and metabolism on the reproductive rate and capacity of single cells in order to link these findings to organismal fitness. ..
    SHIRLEY KOVACS; Fiscal Year: 1991
    ..This project proposes to characterize the Sm and RNP antigens detectable in cyanobacteria in order to determine their relationship to human cell U1RNP antigens...
  49. Specificity/Regulation of Cyanobacterial ABC Transporters
    Nicole Koropatkin; Fiscal Year: 2007
    ..particularly carbon dioxide, is through manipulation of the natural carbon-sequestering mechanisms of aquatic cyanobacteria. One significant factor limiting carbon sequestration in these organisms is the low bioavailability of iron...
  50. Regulation of Cyanobacterial Multicellular Development
    James Golden; Fiscal Year: 2007
    ..This multicellular growth pattern, the distinct phylogeny of cyanobacteria, and the suspected antiquity of heterocyst development make this an important model system...
    Robert Haselkorn; Fiscal Year: 2000
    Mary Allen; Fiscal Year: 1990
    ..or multi-L-arginyl poly (aspartic acid), will be studied during nitrogen starvation using non-nitrogen fixing cyanobacteria as a model system...
    David Williams; Fiscal Year: 2006
    ..neurotoxins, including nerve gas agents; and 4) Discovery of several extremely potent neurotoxins from marine cyanobacteria that give new insights into the structure and function of the mammalian voltage-gated sodium channel, and may ..
    Maria Runnegar; Fiscal Year: 2003
    DESCRIPTION: (Adapted from the Investigator's Abstract) Microcystins are Peptide hepatotoxins produced by cyanobacteria present in water bodies including portable water supplies, constituting an environmental public health hazard...
    HIMADRI PAKRASI; Fiscal Year: 1993
    ..and utilize genetic tools to study the biogenesis and architecture of membrane- bound protein complexes in cyanobacteria. The subject of the immediate investigation is the photosynthetic membrane and in particular, two integral ..
  56. Neurotoxins from Marine Algae and Cyanobacteria
    WILLIAM GERWICK; Fiscal Year: 2004
    The overall goal of this research program is to describe structurally- novel neurotoxins from marine algae and cyanobacteria which can serve as neurochemical probes in mammalian pharmacology and provide new lead compounds for the ..
    Paul Bernstein; Fiscal Year: 2001
    ..In lower animals, such as lobsters and cyanobacteria, specialized carotenoid-binding proteins perform these tasks...
    George Christou; Fiscal Year: 2000
    DESCRIPTION: Water oxidation within the photosynthetic apparatus of plants and cyanobacteria represents a source of protons and electrons for CO2 fixation/carbohydrate synthesis for healthy growth...
    Peter Wipf; Fiscal Year: 2005
    Since 1986, a large number of oxazole- and thiazole-containing secondary metabolites have been isolated from cyanobacteria, nudibranch egg masses, ascidians, and sponges...
    A Norman; Fiscal Year: 1992
  61. Roles of casein kinase le/d and b-Trcp in the mammalian circadian clock
    Choogon Lee; Fiscal Year: 2010
    Circadian rhythms have been observed in nearly all organisms from cyanobacteria to humans...
    Scott Franklin; Fiscal Year: 2000
    ..In addition, we feel this work will have applications toward the expression of other valuable proteins in cyanobacteria. PROPOSED COMMERCIAL APPLICATION: Beyond producing a mosquitocidal cyanobacterial strain with increased half ..
  63. 2009 Mycotoxins and Phycotoxins Gordon Research Conference
    Kathleen Rein; Fiscal Year: 2009
    ..will have a particular emphasis on the influence of climate change on the biogeography of toxic algae, cyanobacteria and fungi;the genomics and proteomics of toxin production;the prediction and detection of hazardous events;and ..