bacteroides

Summary

Summary: A genus of gram-negative, anaerobic, rod-shaped bacteria. Its organisms are normal inhabitants of the oral, respiratory, intestinal, and urogenital cavities of humans, animals, and insects. Some species may be pathogenic.

Top Publications

  1. doi Towards the human intestinal microbiota phylogenetic core
    Julien Tap
    INRA, UEPSD, UR910, 78350 Jouy en Josas, France
    Environ Microbiol 11:2574-84. 2009
  2. pmc Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent
    Laura Wrzosek
    INRA, UMR 1319 Micalis, AgroParisTech, Domaine de Vilvert, Jouy en Josas, France
    BMC Biol 11:61. 2013
  3. pmc Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers
    Jean Pierre Furet
    French National Institute for Agricultural Research, U910, Unité d Ecologie et de Physiologie du Système Digestif, Jouy en Josas, France
    Diabetes 59:3049-57. 2010
  4. doi Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    Diabetes 57:1470-81. 2008
  5. pmc Evolution of symbiotic bacteria in the distal human intestine
    Jian Xu
    Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Biol 5:e156. 2007
  6. pmc A humanized gnotobiotic mouse model of host-archaeal-bacterial mutualism
    Buck S Samuel
    Center for Genome Sciences, Washington University School of Medicine, 4444 Forest Park, St Louis, MO 63108, USA
    Proc Natl Acad Sci U S A 103:10011-6. 2006
  7. ncbi A genomic view of the human-Bacteroides thetaiotaomicron symbiosis
    Jian Xu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 299:2074-6. 2003
  8. pmc Recognition and degradation of plant cell wall polysaccharides by two human gut symbionts
    Eric C Martens
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Biol 9:e1001221. 2011
  9. pmc Identifying genetic determinants needed to establish a human gut symbiont in its habitat
    Andrew L Goodman
    Center for Genome Sciences, Washington University School of Medicine, St Louis, MO 63108, USA
    Cell Host Microbe 6:279-89. 2009
  10. pmc Specificity of polysaccharide use in intestinal bacteroides species determines diet-induced microbiota alterations
    Erica D Sonnenburg
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 141:1241-52. 2010

Detail Information

Publications359 found, 100 shown here

  1. doi Towards the human intestinal microbiota phylogenetic core
    Julien Tap
    INRA, UEPSD, UR910, 78350 Jouy en Josas, France
    Environ Microbiol 11:2574-84. 2009
    ..dominant and prevalent OTUs included members of the genera Faecalibacterium, Ruminococcus, Eubacterium, Dorea, Bacteroides, Alistipes and Bifidobacterium...
  2. pmc Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent
    Laura Wrzosek
    INRA, UMR 1319 Micalis, AgroParisTech, Domaine de Vilvert, Jouy en Josas, France
    BMC Biol 11:61. 2013
    ..the host and microbiota, we used gnotobiotic models to study the influence of two major commensal bacteria, Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii, on this intestinal mucus layer. B...
  3. pmc Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers
    Jean Pierre Furet
    French National Institute for Agricultural Research, U910, Unité d Ecologie et de Physiologie du Système Digestif, Jouy en Josas, France
    Diabetes 59:3049-57. 2010
    ..We analyzed the impact of RYGB on the modifications of gut microbiota and examined links with adaptations associated with this procedure...
  4. doi Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    Diabetes 57:1470-81. 2008
    ..e., metabolic endotoxemia. Therefore, it remained to demonstrate whether changes in gut microbiota control the occurrence of metabolic diseases...
  5. pmc Evolution of symbiotic bacteria in the distal human intestine
    Jian Xu
    Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Biol 5:e156. 2007
    ..genome evolution, we have sequenced the genomes of two members of the normal distal human gut microbiota, Bacteroides vulgatus and Bacteroides distasonis, and by comparison with the few other sequenced gut and non-gut ..
  6. pmc A humanized gnotobiotic mouse model of host-archaeal-bacterial mutualism
    Buck S Samuel
    Center for Genome Sciences, Washington University School of Medicine, 4444 Forest Park, St Louis, MO 63108, USA
    Proc Natl Acad Sci U S A 103:10011-6. 2006
    ..To examine the contributions of Archaea to digestive health, we colonized germ-free mice with Bacteroides thetaiotaomicron, an adaptive bacterial forager of the polysaccharides that we consume, with or without M...
  7. ncbi A genomic view of the human-Bacteroides thetaiotaomicron symbiosis
    Jian Xu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 299:2074-6. 2003
    ..Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron, a dominant member of our normal distal intestinal microbiota...
  8. pmc Recognition and degradation of plant cell wall polysaccharides by two human gut symbionts
    Eric C Martens
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Biol 9:e1001221. 2011
    ..Here we show that two closely related human gut Bacteroides, B. thetaiotaomicron and B...
  9. pmc Identifying genetic determinants needed to establish a human gut symbiont in its habitat
    Andrew L Goodman
    Center for Genome Sciences, Washington University School of Medicine, St Louis, MO 63108, USA
    Cell Host Microbe 6:279-89. 2009
    ..the relative abundance of tens of thousands of transposon mutants of a saccharolytic human gut bacterium, Bacteroides thetaiotaomicron, as they established themselves in wild-type and immunodeficient gnotobiotic mice, in the ..
  10. pmc Specificity of polysaccharide use in intestinal bacteroides species determines diet-induced microbiota alterations
    Erica D Sonnenburg
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 141:1241-52. 2010
    ..Here we elucidate the basis of Bacteroides proliferation in response to fructans, a class of fructose-based dietary polysaccharides...
  11. doi Microbiota and SCFA in lean and overweight healthy subjects
    Andreas Schwiertz
    Institute of Microecology, Auf den Lüppen 8, Herborn, Germany
    Obesity (Silver Spring) 18:190-5. 2010
    ..However, our results contradict previous reports with regard to the contribution of various bacterial groups to the development of obesity and this issue remains controversial...
  12. ncbi Human intestinal bacteria as reservoirs for antibiotic resistance genes
    Abigail A Salyers
    Department of Microbiology, University of Illinois, Urbana, IL 61801, USA
    Trends Microbiol 12:412-6. 2004
    ....
  13. doi Comparative assessment of human and farm animal faecal microbiota using real-time quantitative PCR
    Jean Pierre Furet
    INRA, U910, Unité d Ecologie et de Physiologie du Système Digestif, Jouy en Josas, France
    FEMS Microbiol Ecol 68:351-62. 2009
    ..Three dominant bacterial groups (Bacteroides/Prevotella, Clostridium coccoides and Bifidobacterium) of the human microbiota showed differential population ..
  14. pmc OPT-80 eliminates Clostridium difficile and is sparing of bacteroides species during treatment of C. difficile infection
    Thomas J Louie
    Department of Medicine, Division of Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    Antimicrob Agents Chemother 53:261-3. 2009
    ..difficile counts. Bacteroides fragilis group counts appeared unaffected with increasing dosages of OPT-80, whereas vancomycin was markedly ..
  15. pmc Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon
    P Seksik
    INRA, CR de Jouy en Josas, 78352 Jouy en Josas, France
    Gut 52:237-42. 2003
    ..We investigated potential differences in the faecal microflora between patients with colonic CD in remission (n=9), patients with active colonic CD (n=8), and healthy volunteers (n=16) using culture independent techniques...
  16. doi Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice
    Mathieu Membrez
    Nestle Research Center, P O Box 44, CH 1000 Lausanne, Switzerland
    FASEB J 22:2416-26. 2008
    ....
  17. ncbi Application of a suite of 16S rRNA-specific oligonucleotide probes designed to investigate bacteria of the phylum cytophaga-flavobacter-bacteroides in the natural environment
    W Manz
    Lehrstuhl fur Mikrobiologie, Technische Universitat Munchen, Germany
    Microbiology 142:1097-106. 1996
    ..of four 16S rRNA-targeted oligonucleotide probes specific for bacteria of the phylum cytophaga-flavobacter-bacteroides (CFB)...
  18. ncbi IgA response to symbiotic bacteria as a mediator of gut homeostasis
    Daniel A Peterson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63108, USA
    Cell Host Microbe 2:328-39. 2007
    ..b>Bacteroides thetaiotaomicron was introduced into germ-free wild-type, immunodeficient Rag1(-/-), or Rag1(-/-) mice ..
  19. pmc Multidomain Carbohydrate-binding Proteins Involved in Bacteroides thetaiotaomicron Starch Metabolism
    Elizabeth A Cameron
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 287:34614-25. 2012
    Human colonic bacteria are necessary for the digestion of many dietary polysaccharides. The intestinal symbiont Bacteroides thetaiotaomicron uses five outer membrane proteins to bind and degrade starch...
  20. ncbi Glycan foraging in vivo by an intestine-adapted bacterial symbiont
    Justin L Sonnenburg
    Center for Genome Sciences, Washington University, St Louis, MO 63108, USA
    Science 307:1955-9. 2005
    ..polysaccharide-rich or simple-sugar diets and colonized for 10 days with an organism also found in human guts, Bacteroides thetaiotaomicron, followed by whole-genome transcriptional profiling of bacteria and mass spectrometry of cecal ..
  21. doi Species identification of clinical isolates of Bacteroides by matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry
    E Nagy
    Institute of Clinical Microbiology, University of Szeged, H 6701 Szeged, Hungary
    Clin Microbiol Infect 15:796-802. 2009
    b>Bacteroides fragilis and related species are important human pathogens involved in mixed infections of different origins. The B...
  22. pmc Influence of environmental and genetic factors linked to celiac disease risk on infant gut colonization by Bacteroides species
    Ester Sanchez
    Ecofisiología Microbiana y Nutrición, Instituto de Agroquimica y Tecnologia de Alimentos CSIC, Avda Agustín Escardino 7, 46980 Paterna, Valencia, Spain
    Appl Environ Microbiol 77:5316-23. 2011
    ..was to determine the effects of milk-feeding practices and the HLA-DQ genotype on intestinal colonization of Bacteroides species in infants at risk of CD development...
  23. pmc Bacteroides: the good, the bad, and the nitty-gritty
    Hannah M Wexler
    Wadsworth Anaerobe Laboratory, Greater Los Angeles VA Healthcare Systems University of California, Los Angeles, CA 90073, USA
    Clin Microbiol Rev 20:593-621. 2007
    b>Bacteroides species are significant clinical pathogens and are found in most anaerobic infections, with an associated mortality of more than 19%...
  24. pmc Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease
    Seth M Bloom
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Host Microbe 9:390-403. 2011
    ..From screening experiments we isolated common commensal Bacteroides species, introduced them into antibiotic-pretreated mice, and quantitatively reisolated them in culture...
  25. pmc Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, Roseburia and Bacteroides/Prevotella in diet-induced obese mice
    Audrey M Neyrinck
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    PLoS ONE 6:e20944. 2011
    ..We test the ability of a specific concentrate of water-extractable high molecular weight arabinoxylans (AX) from wheat to modulate both the gut microbiota and lipid metabolism in high-fat (HF) diet-induced obese mice...
  26. ncbi Mixed infection of Porphyromonas gingivalis and Bacteroides forsythus in a murine abscess model: involvement of gingipains in a synergistic effect
    M Yoneda
    Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
    J Periodontal Res 36:237-43. 2001
    Several microorganisms including Porphyromonas gingivalis and Bacteroides forsythus have been implicated to be etiologically important agents of periodontal disease...
  27. pmc How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity
    Fiona Cuskin
    Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
    Proc Natl Acad Sci U S A 109:20889-94. 2012
    ..Conversely, appending BsCBM66 to BT3082, a nonspecific β-fructosidase from Bacteroides thetaiotaomicron, confers exolevanase activity on the enzyme...
  28. pmc Bacteroides uniformis CECT 7771 ameliorates metabolic and immunological dysfunction in mice with high-fat-diet induced obesity
    Paola Gauffin Cano
    Microbial Ecology and Nutrition Research Group, Institute of Agrochemistry and Food Technology IATA, National Research Council CSIC, Valencia, Spain
    PLoS ONE 7:e41079. 2012
    ..Herein, the effects of Bacteroides uniformis CECT 7771 on obesity-related metabolic and immune alterations have been evaluated.
  29. doi Panose, a new prebiotic candidate
    H Mäkeläinen
    Health and Nutrition, Danisco Finland, Kantvik, Finland
    Lett Appl Microbiol 49:666-72. 2009
    ..To investigate the prebiotic potential of two novel candidates, sophorose and panose, with in vitro methods...
  30. ncbi The surface (S-) layer is a virulence factor of Bacteroides forsythus
    M Sabet
    Department of Biomedical Sciences, University of Maryland, Baltimore, Dental School, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Microbiology 149:3617-27. 2003
    b>Bacteroides forsythus has emerged as a crucial periodontal pathogen with possible implications for systemic disease. The aim of this study was to isolate the S-layer from B...
  31. pmc Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine
    Dingding An
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:4666-71. 2011
    As predominant intestinal symbiotic bacteria, Bacteroides are essential in maintaining the health of the normal mammalian host; in return, the host provides a niche with plentiful nutrients for the symbionts...
  32. ncbi Clindamycin-induced enrichment and long-term persistence of resistant Bacteroides spp. and resistance genes
    Sonja Lofmark
    Department of Laboratory Medicine, Karolinska Institute, SE 141 86 Stockholm, Sweden
    J Antimicrob Chemother 58:1160-7. 2006
    The aim was to study the long-term consequences of 1 week clindamycin administration regarding selection and persistence of resistance, resistance determinants and diversity of the Bacteroides spp. in the intestinal microflora.
  33. doi Combined PCR-DGGE fingerprinting and quantitative-PCR indicates shifts in fecal population sizes and diversity of Bacteroides, bifidobacteria and Clostridium cluster IV in institutionalized elderly
    Jutta Zwielehner
    Department of Nutritional Sciences, University of Vienna, Austria
    Exp Gerontol 44:440-6. 2009
    ..This study aimed at determining ageing-related shifts in diversity and composition of key members of the fecal microbiota by comparing institutionalized elderly (n = 17, 78-94 years) and young volunteers (n = 17, 18-31 years)...
  34. ncbi Angiogenins: a new class of microbicidal proteins involved in innate immunity
    Lora V Hooper
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nat Immunol 4:269-73. 2003
    ..Ang4 expression is induced by Bacteroides thetaiotaomicron, a predominant member of the gut microflora, revealing a mechanism whereby intestinal ..
  35. pmc Cloning, expression, and sequencing of a cell surface antigen containing a leucine-rich repeat motif from Bacteroides forsythus ATCC 43037
    A Sharma
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Infect Immun 66:5703-10. 1998
    b>Bacteroides forsythus is a recently recognized human periodontopathogen associated with advanced, as well as recurrent, periodontitis. However, very little is known about the mechanism of pathogenesis of this organism...
  36. pmc Starch catabolism by a prominent human gut symbiont is directed by the recognition of amylose helices
    Nicole M Koropatkin
    Donald Danforth Plant Science Center, St Louis, MO 63132, USA
    Structure 16:1105-15. 2008
    ..we describe the atomic structure of one such protein, SusD, required for starch binding and utilization by Bacteroides thetaiotaomicron, a prominent adaptive forager of glycans in the distal human gut microbiota...
  37. pmc Mucosal glycan foraging enhances fitness and transmission of a saccharolytic human gut bacterial symbiont
    Eric C Martens
    Center for Genome Sciences, Washington University School of Medicine, St Louis, MO 63108, USA
    Cell Host Microbe 4:447-57. 2008
    ..The human gut-derived bacterium Bacteroides thetaiotaomicron forages on both host and dietary glycans...
  38. pmc Honor thy symbionts
    Jian Xu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:10452-9. 2003
    ..These points are illustrated by the human-Bacteroides thetaiotaomicron symbiosis...
  39. ncbi Inter-species transplantation of gut microbiota from human to pigs
    Xiaoyan Pang
    Department of Bioscience and Biotechnology, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
    ISME J 1:156-62. 2007
    ..This HFA model provides a significantly improved system for research on gut ecology in human metabolism, nutrition and drug discovery...
  40. doi Structural insight into the mechanism of streptozotocin inhibition of O-GlcNAcase
    Yuan He
    Department of Chemistry, Structural Biology Laboratory, The University of York, Heslington, York, YO10 5YW, UK
    Carbohydr Res 344:627-31. 2009
    ..In this report, we explore the binding mode of STZ to a close homolog of human O-GlcNAcase, BtGH84 from Bacteroides thetaiotaomicron...
  41. ncbi Bacteroides thetaiotaomicron: a dynamic, niche-adapted human symbiont
    Laurie E Comstock
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Bioessays 25:926-9. 2003
    ..b>Bacteroides thetaiotaomicron is one such bacterial symbiont that is a dominant member of the intestinal microbiota of ..
  42. ncbi Bacteroides induce higher IgA production than Lactobacillus by increasing activation-induced cytidine deaminase expression in B cells in murine Peyer's patches
    Tsutomu Yanagibashi
    Department of Food Science and Technology, Nihon University, Fujisawa shi, Kanagawa, Japan
    Biosci Biotechnol Biochem 73:372-7. 2009
    ..In this study, we compared the immunomodulatory effects of Bacteroides and Lactobacillus on IgA production by Peyer's patches lymphocytes...
  43. ncbi Host-bacterial mutualism in the human intestine
    Fredrik Backhed
    Center for Genome Sciences, Washington University School of Medicine, St Louis, MO 63108, USA
    Science 307:1915-20. 2005
    ..We are also starting to understand how certain keystone members of the microbiota operate to maintain the stability and functional adaptability of this microbial organ...
  44. ncbi Frequent occurrence of the human-specific Bacteroides fecal marker at an open coast marine beach: relationship to waves, tides and traditional indicators
    Alyson E Santoro
    Department of Civil and Environmental Engineering, Stanford University, Stanford, CA 94305, USA
    Environ Microbiol 9:2038-49. 2007
    Molecular genetic markers, such as those from fecal Bacteroides microorganisms, can link microbial pollution with its source, and have been used successfully in studies of sheltered aquatic environments...
  45. pmc pH and peptide supply can radically alter bacterial populations and short-chain fatty acid ratios within microbial communities from the human colon
    Alan W Walker
    Microbial Genetics Group, Rowett Research Institute, Greenburn Rd, Bucksburn, Aberdeen AB21 9SB, United Kingdom
    Appl Environ Microbiol 71:3692-700. 2005
    ..b>Bacteroides levels increased from ca. 20 to 75% of total eubacteria after a shift from pH 5.5 to 6.5, at 0...
  46. pmc Development of Bacteroides 16S rRNA gene TaqMan-based real-time PCR assays for estimation of total, human, and bovine fecal pollution in water
    Alice Layton
    The University of Tennessee, Center for Environmental Biotechnology, 676 Dabney Hall, Knoxville, TN 37996 1605, USA
    Appl Environ Microbiol 72:4214-24. 2006
    b>Bacteroides species are promising indicators for differentiating livestock and human fecal contamination in water because of their high concentration in feces and potential host specificity...
  47. ncbi Bacteroides dorei sp. nov., isolated from human faeces
    Mohammad Abdul Bakir
    Microbe Division Japan Collection of Microorganisms, RIKEN BioResource Center, Wako, Saitama 351 0198, Japan
    Int J Syst Evol Microbiol 56:1639-43. 2006
    ..These isolates were tentatively identified as Bacteroides based on morphological and biochemical criteria and appeared closely related to Bacteroides vulgatus ATCC 8482(..
  48. pmc Biochemical analysis of interactions between outer membrane proteins that contribute to starch utilization by Bacteroides thetaiotaomicron
    K H Cho
    Department of Microbiology, University of Illinois, Urbana, Illinois 61801, USA
    J Bacteriol 183:7224-30. 2001
    An early step in the utilization of starch by Bacteroides thetaiotaomicron is the binding of starch to the bacterial surface. Four starch-associated outer membrane proteins of B...
  49. ncbi Monocolonization with Bacteroides ovatus protects immunodeficient SCID mice from mortality in chronic intestinal inflammation caused by long-lasting dextran sodium sulfate treatment
    T Hudcovic
    Department of Immunology, Academy of Sciences of the Czech Republic, Novy Hradek, Czech Republic
    Physiol Res 58:101-10. 2009
    This study was aimed to evaluate the role of commensal Gram-negative bacterium Bacteroides ovatus in murine model of chronic intestinal inflammation...
  50. pmc Coordinate regulation of glycan degradation and polysaccharide capsule biosynthesis by a prominent human gut symbiont
    Eric C Martens
    Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Biol Chem 284:18445-57. 2009
    ..The human gut bacterium Bacteroides thetaiotaomicron is well endowed with the ability to metabolize both host- and diet-derived glycans...
  51. pmc Dynamic responses of Bacteroides thetaiotaomicron during growth on glycan mixtures
    Theresa E Rogers
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Mol Microbiol 88:876-90. 2013
    b>Bacteroides thetaiotaomicron (Bt) is a human colonic symbiont that degrades many different complex carbohydrates (glycans), the identities and amounts of which are likely to change frequently and abruptly from meal-to-meal...
  52. pmc Effects of diet on resource utilization by a model human gut microbiota containing Bacteroides cellulosilyticus WH2, a symbiont with an extensive glycobiome
    Nathan P McNulty
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Biol 11:e1001637. 2013
    ..High-resolution shotgun metaproteomics confirmed many of these responses at a protein level. One member, Bacteroides cellulosilyticus WH2, proved exceptionally fit regardless of diet...
  53. pmc Structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen
    Nethaji Thiyagarajan
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Sci Rep 2:940. 2012
    ..Here we report the first structure of a bacterial GT of this family, from an intestinal resident, Bacteroides ovatus...
  54. doi Escherichia coli, enterococci, and Bacteroides thetaiotaomicron qPCR signals through wastewater and septage treatment
    Sangeetha Srinivasan
    Department of Fisheries and Wildlife, 13, Natural Resources, Michigan State University, East Lansing, MI 48824, USA
    Water Res 45:2561-72. 2011
    ..This critical uncertainty has furthered water pollution science toward new molecular approaches. Members of Bacteroides genus, such as Bacteroides thetaiotaomicron are found to have features that allow their use as alternative ..
  55. doi IgA production in the large intestine is modulated by a different mechanism than in the small intestine: Bacteroides acidifaciens promotes IgA production in the large intestine by inducing germinal center formation and increasing the number of IgA+ B cell
    Tsutomu Yanagibashi
    Department of Food Bioscience and Biotechnology, College of Bioresource Sciences, Nihon University, Kanagawa 252 0880, Japan
    Immunobiology 218:645-51. 2013
    ..with different murine commensal bacteria by inoculating germ-free (GF) mice with Lactobacillus johnsonii or Bacteroides acidifaciens...
  56. doi Detection of the human specific Bacteroides genetic marker provides evidence of widespread sewage contamination of stormwater in the urban environment
    Elizabeth P Sauer
    Great Lakes WATER Institute, UW Milwaukee, 600 E Greenfield Ave, Milwaukee, WI 53204, USA
    Water Res 45:4081-91. 2011
    ..All outfalls had the HF183 (human) Bacteroides genetic marker detected in at least one sample, suggesting sewage contamination is nearly ubiquitous in the ..
  57. pmc Regulated virulence controls the ability of a pathogen to compete with the gut microbiota
    Nobuhiko Kamada
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Science 336:1325-9. 2012
    ..Thus, pathogen colonization is controlled by bacterial virulence and through competition with metabolically related commensals...
  58. doi Re-assessment of phenotypic identifications of Bacteroides putredinis to Alistipes species using molecular methods
    Kerin L Tyrrell
    R M Alden Research Laboratory, Culver City, CA 90230, USA
    Anaerobe 17:130-4. 2011
    Alistipes (previously Bacteroides) are strictly anaerobic gram-negative rods that resemble the Bacteroides fragilis group in that most species are bile-resistant and indole-positive; however, they are only weakly saccharolytic and most ..
  59. ncbi Metronidazole resistance in Bacteroides spp. carrying nim genes and the selection of slow-growing metronidazole-resistant mutants
    Micaela Gal
    Anaerobe Reference Laboratory, National Public Health Service Wales, Microbiology Cardiff, University Hospital of Wales, Cardiff CF14 4XW, UK
    J Antimicrob Chemother 54:109-16. 2004
    Human clinical isolates of Bacteroides spp...
  60. pmc Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study
    Susanne Mueller
    Abteilung Gastrointestinale Mikrobiologie, Deutsches Institut für Ernährungsforschung Potsdam Rehbrücke, Nuthetal, Germany
    Appl Environ Microbiol 72:1027-33. 2006
    ..interactions were inverse for the predominant bacterial groups Eubacterium rectale-Clostridium coccoides and Bacteroides-Prevotella. Differences between European populations were observed for the Bifidobacterium group only...
  61. doi Intestinal Bacteroides species associated with coeliac disease
    Ester Sanchez
    Microbial Ecology and Nutrition Research Group, Instituto de Agroquimica y Tecnologia de Alimentos, Consejo Superior de Investigaciones Cientificas, Valencia, Spain
    J Clin Pathol 63:1105-11. 2010
    ..To characterise the predominant species of bacterial populations associated with duodenal biopsies of paediatric patients with active and treated coeliac disease...
  62. doi Characterization of the first alginolytic operons in a marine bacterium: from their emergence in marine Flavobacteriia to their independent transfers to marine Proteobacteria and human gut Bacteroides
    François Thomas
    UPMC University Paris 6, UMR 7139 Marine Plants and Biomolecules, Station Biologique de Roscoff, F 29682 Roscoff, Brittany, France
    Environ Microbiol 14:2379-94. 2012
    ..an ancestral marine flavobacterium and were independently transferred to marine proteobacteria and Japanese gut Bacteroides. These bacteria thus gained the capacity to assimilate the main polysaccharide of brown algae, an adaptive ..
  63. pmc Sulfatases and a radical S-adenosyl-L-methionine (AdoMet) enzyme are key for mucosal foraging and fitness of the prominent human gut symbiont, Bacteroides thetaiotaomicron
    Alhosna Benjdia
    INRA, UMR1319 MICALIS, F 78352 Jouy en Josas, France
    J Biol Chem 286:25973-82. 2011
    ..Commensal bacteria such as Bacteroides thetaiotaomicron possess more predicted sulfatase genes than in the human genome, the physiological functions ..
  64. pmc Comparison of the benzoyl-DL-arginine-naphthylamide (BANA) test, DNA probes, and immunological reagents for ability to detect anaerobic periodontal infections due to Porphyromonas gingivalis, Treponema denticola, and Bacteroides forsythus
    W J Loesche
    Department of Biological and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor 48109 1078
    J Clin Microbiol 30:427-33. 1992
    ..or overgrowth of anaerobic species that could include Treponema denticola, Porphyromonas gingivalis, and Bacteroides forsythus among others...
  65. doi Moxifloxacin resistance is prevalent among Bacteroides and Prevotella species in Greece
    Joseph Papaparaskevas
    Department of Microbiology, Medical School, University of Athens, 11527 Athens, Greece
    J Antimicrob Chemother 62:137-41. 2008
    ..However, current European data regarding its activity against anaerobic pathogens are limited. In order to evaluate its potency, we comparatively studied the activity of moxifloxacin against recently isolated Gram-negative anaerobes...
  66. pmc Transcriptomic analyses of xylan degradation by Prevotella bryantii and insights into energy acquisition by xylanolytic bacteroidetes
    Dylan Dodd
    Department of Microbiology, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 285:30261-73. 2010
    ..membrane proteins analogous to the starch utilization system identified in the prominent human gut symbiont Bacteroides thetaiotaomicron...
  67. pmc A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem
    L V Hooper
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 96:9833-8. 1999
    ..We have used a gnotobiotic mouse model to show that Bacteroides thetaiotaomicron, a component of the intestinal microflora of mice and humans, uses a repressor, FucR, as a ..
  68. ncbi Prevalence of Bacteroides and Prevotella spp. in ulcerative colitis
    Katja Lucke
    Institute of Medical Microbiology, Canton Hospital Luzern, Switzerland
    J Med Microbiol 55:617-24. 2006
    ..The investigation revealed an abundance of sequences from Bacteroides spp. and Prevotella spp...
  69. pmc Characterization of a metal-independent CAZy family 6 glycosyltransferase from Bacteroides ovatus
    Percy Tumbale
    Department of Basic Science, Charles E Schmidt College of Biomedical Science, Florida Atlantic University, Boca Raton, Florida 33431, USA
    J Biol Chem 284:25126-34. 2009
    ..We have cloned and expressed one of these proteins from Bacteroides ovatus, a bacterium that is linked to inflammatory bowel disease...
  70. ncbi Detection of Tannerella forsythensis (Bacteroides forsythus) and porphyromonas gingivalis by polymerase chain reaction in subjects with different periodontal status
    Marlise I Klein
    Division of Microbiology and Immunology, Department of Oral Diagnostics, School of Dentistry at Piracicaba, Sao Paulo, Brazil
    J Periodontol 74:798-802. 2003
    The aim of this study was to determine the prevalence of Tannerella forsythensis (formerly Bacteroides forsythus) and Porphyromonas gingivalis in subgingival plaque samples by using polymerase chain reaction (PCR), and to assess the ..
  71. ncbi "Red complex" (Bacteroides forsythus, Porphyromonas gingivalis, and Treponema denticola) in endodontic infections: a molecular approach
    I N Rôças
    Department of Endodontics, School of Dentistry, Estacio de Sa University, Rio de Janeiro, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:468-71. 2001
    The "red complex," composed of Bacteroides forsythus, Porphyromonas gingivalis, and Treponema denticola, is implicated in severe forms of periodontal diseases...
  72. pmc Bacteroides ovatus as the predominant commensal intestinal microbe causing a systemic antibody response in inflammatory bowel disease
    Shin Saitoh
    Departments of Infectious Diseases Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Clin Diagn Lab Immunol 9:54-9. 2002
    ..In IBD patients, as a result, significant elevations of both the immunoglobulin G (IgG) and IgA titers to Bacteroides ovatus were found. Immunoblotting showed that a definite 19.5-kDa band of B...
  73. pmc Genetic diversity of viable, injured, and dead fecal bacteria assessed by fluorescence-activated cell sorting and 16S rRNA gene analysis
    Kaouther Ben-Amor
    Laboratory of Microbiology, Wageningen University, Hesselink van Suchtelenweg 4, 6703 CT Wageningen, The Netherlands
    Appl Environ Microbiol 71:4679-89. 2005
    ..retrieved from the live, injured, and dead fractions belonged to Clostridium coccoides, Clostridium leptum, and Bacteroides. We found that some of the butyrate-producing related bacteria, such as Eubacterium rectale and Eubacterium ..
  74. ncbi Can presence or absence of periodontal pathogens distinguish between subjects with chronic and aggressive periodontitis? A systematic review
    Andrea Mombelli
    School of Dental Medicine, University of Geneva, Switzerland
    J Clin Periodontol 29:10-21; discussion 37-8. 2002
    ..The purpose of this study was to determine to what extent the presence or absence of periodontal pathogens can distinguish between subjects with chronic and aggressive periodontitis...
  75. doi Reclassification of Bacteroides ureolyticus as Campylobacter ureolyticus comb. nov., and emended description of the genus Campylobacter
    P Vandamme
    Laboratory of Microbiology, K L Ledeganckstraat 35, Universiteit Gent, Ghent, Belgium
    Int J Syst Evol Microbiol 60:2016-22. 2010
    ..fragment length polymorphism patterns and 16S rRNA and cpn60 gene sequences of a diverse collection of 26 Bacteroides ureolyticus strains, along with published data on their DNA base, respiratory quinone and cellular fatty acid ..
  76. doi Genetic determinants for cfxA expression in Bacteroides strains isolated from human infections
    Nuria Garcia
    Departamento de Medicina y Sanidad Animal, Facultad de Veterinaria, Universidad de Extremadura, Avda de la Universidad s n, 10071 Caceres, Spain
    J Antimicrob Chemother 62:942-7. 2008
    To identify genetic determinants that determine beta-lactamase expression in Bacteroides strains isolated from human infections.
  77. doi Importance of glycans to the host-bacteroides mutualism in the mammalian intestine
    Laurie E Comstock
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cell Host Microbe 5:522-6. 2009
    Much of the mutualistic relationship between humans and their resident intestinal Bacteroides species is founded on glycans...
  78. pmc Bacteroides sp. strain D8, the first cholesterol-reducing bacterium isolated from human feces
    Philippe Gerard
    Unité d Ecologie et Physiologie du Système Digestif, INRA, Bâtiment J Poly, Domaine de Vilvert, 78352 Jouy en Josas Cedex, France
    Appl Environ Microbiol 73:5742-9. 2007
    ..Strain D8 was a gram-negative, non-spore-forming, rod-shaped organism identified as a member of the genus Bacteroides closely related to Bacteroides vulgatus, based on its morphological and biochemical characteristics...
  79. doi Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota
    Jan Hendrik Hehemann
    Universite Pierre et Marie Curie, Paris, France
    Nature 464:908-12. 2010
    ..The array of CAZymes in gut microbes is highly diverse, exemplified by the human gut symbiont Bacteroides thetaiotaomicron, which contains 261 glycoside hydrolases and polysaccharide lyases, as well as 208 homologues ..
  80. pmc Genomic and metabolic studies of the impact of probiotics on a model gut symbiont and host
    Justin L Sonnenburg
    Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Biol 4:e413. 2006
    ..To address this issue, we colonized germ-free mice with Bacteroides thetaiotaomicron, a prominent component of the adult human gut microbiota, and Bifidobacterium longum, a minor ..
  81. pmc Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells
    Thaddeus S Stappenbeck
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 99:15451-5. 2002
    ..within 10 days after colonization with a complete microbiota harvested from conventionally raised mice, or with Bacteroides thetaiotaomicron, a prominent inhabitant of the normal mouse/human gut...
  82. ncbi Quantitation of Bacteroides forsythus in subgingival plaque comparison of immunoassay and quantitative polymerase chain reaction
    C E Shelburne
    3M Company, St Paul, MI 55144, USA
    J Microbiol Methods 39:97-107. 2000
    ..endpoint and quantitative polymerase chain reaction [E-PCR and Q-PCR]) for detection and quantitation of Bacteroides forsythus in 56 plaque samples from seven subjects with progressive periodontal disease...
  83. ncbi Relationship between the presence of certain bacterial pathogens and periodontal status of urban Thai adults
    Kitti Torrungruang
    Department of Microbiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand
    J Periodontol 80:122-9. 2009
    ..However, corresponding data in Asian populations are still lacking. The aim of this study was to determine the prevalence of these three bacteria and their relationship to periodontal status in a group of urban Thai adults...
  84. pmc Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut
    A Suau
    Laboratoire d Ecologie et Physiologie du Système Digestif, Institut National de la Recherche Agronomique, 78352 Jouy en Josas Cedex, France
    Appl Environ Microbiol 65:4799-807. 1999
    ..Three phylogenetic groups contained 95% of the clones: the Bacteroides group, the Clostridium coccoides group, and the Clostridium leptum subgroup...
  85. doi Xylan-regulated delivery of human keratinocyte growth factor-2 to the inflamed colon by the human anaerobic commensal bacterium Bacteroides ovatus
    Zaed Z R Hamady
    Institute of Molecular and Cellular Biology, University of Leeds, UK
    Gut 59:461-9. 2010
    ..Live microorganism-based delivery systems can overcome these problems although they suffer from the inability to control heterologous protein production and there are concerns regarding biosafety and environmental contamination...
  86. ncbi Comparison of microbial cultivation and a commercial PCR based method for detection of periodontopathogenic species in subgingival plaque samples
    Sigrun Eick
    Department of Microbiological Microbiology, University Hospital of Jena, Germany
    J Clin Periodontol 29:638-44. 2002
    ..The purpose of this study was to validate the commercially available micro-Dent(R) test which employs probes for A. actinomycetemcomitans, P. gingivalis, P. intermedia, B. forsythus and T. denticola...
  87. pmc Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease
    M P Conte
    Paediatric Gastroenterology Unit, University of Rome La Sapienza, Viale Regina Elena 324, Rome 00161, Italy
    Gut 55:1760-7. 2006
    ..No paediatric reports are available on intestinal endogenous microflora in IBD...
  88. ncbi Bacteroides cellulosilyticus sp. nov., a cellulolytic bacterium from the human gut microbial community
    Céline Robert
    Unite de Microbiologie, INRA, Centre de Recherches de Clermont Ferrand Theix, 63 122 Saint Genès Champanelle, France
    Int J Syst Evol Microbiol 57:1516-20. 2007
    ..1 mol%. 16S rRNA gene sequence analysis revealed that the isolate belonged to the genus Bacteroides with highest sequence similarity to the type strain of Bacteroides intestinalis (98 %)...
  89. ncbi Message from a human gut symbiont: sensitivity is a prerequisite for sharing
    Jian Xu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Trends Microbiol 12:21-8. 2004
    ..The intestine contains our largest collection of symbionts, where members of Bacteroides comprise approximately 25% of the microbiota in adults...
  90. pmc A new Bacteroides conjugative transposon that carries an ermB gene
    Anamika Gupta
    Department of Microbiology, University of Illinois, Urbana, Illinois 61801, USA
    Appl Environ Microbiol 69:6455-63. 2003
    ..This gene has also been found in Bacteroides species but only in six recently isolated strains; thus, the gene seems to have entered this genus only ..
  91. ncbi The application of a recently isolated strain of Bacteroides (GB-124) to identify human sources of faecal pollution in a temperate river catchment
    James Ebdon
    Environment and Public Health Research Unit, School of the Environment, University of Brighton, Cockcroft Building, Lewes Road, Brighton BN2 4GJ, UK
    Water Res 41:3683-90. 2007
    Recent work has suggested that bacteriophages infecting Bacteroides are a potential tool for faecal source tracking, but that different host strains may be needed for different geographic areas...
  92. ncbi Molecular investigation of genetic elements contributing to metronidazole resistance in Bacteroides strains
    József Sóki
    Instutute of Clinical Microbiology, University of Szeged, H 6725 Szeged, Somogyi Béla tér 1, Hungary
    J Antimicrob Chemother 57:212-20. 2006
    ..of nim gene types, their activating insertion sequence (IS) element, their localization (plasmid or chromosome) and cfiA gene status in metronidazole-resistant Bacteroides strains (n=26) in order to examine their interchangeability.
  93. ncbi Chemotaxonomic analysis of bacterial populations colonizing the rectal mucosa in patients with ulcerative colitis
    Sandra Macfarlane
    Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital Medical School, Dundee, United Kingdom
    Clin Infect Dis 38:1690-9. 2004
    ..Interindividual variations in mucosal biofilms made it difficult to assign a role for specific bacteria in UC etiology. However, differences in bifidobacteria and peptostreptococci may implicate these organisms in this disease...
  94. pmc Crystal structure of the ligand-binding form of nanoRNase from Bacteroides fragilis, a member of the DHH/DHHA1 phosphoesterase family of proteins
    Yuri Uemura
    Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    FEBS Lett 587:2669-74. 2013
    ..GMP binds near the DHHA1 motif region in the C-terminal domain. Our structure enables us to predict the substrate-bound form of Nrn as well as other DHH/DHHA1 phosphoesterase family proteins...
  95. ncbi Microbiological findings in subjects with asymptomatic oral lichen planus: a cross-sectional comparative study
    Michael M Bornstein
    Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern, Bern, Switzerland
    J Periodontol 79:2347-55. 2008
    ..The bacterial colonization of the oral mucosa was evaluated in patients with asymptomatic oral lichen planus (OLP) and compared to the microbiologic status in mucosally healthy subjects...
  96. pmc The colitis-associated transcriptional profile of commensal Bacteroides thetaiotaomicron enhances adaptive immune responses to a bacterial antigen
    Jonathan J Hansen
    Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e42645. 2012
    ..immune responses to commensal intestinal microbes including the well-characterized anaerobic gut commensal Bacteroides thetaiotaomicron (B. theta)...
  97. pmc First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina
    Liliana Fernández-Canigia
    Subcomisión de Bacterias Anaerobias, SADEBAC, Asociación Argentina de Microbiología, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
    Antimicrob Agents Chemother 56:1309-14. 2012
    The antibiotic susceptibility rates of 363 clinical Bacteroides fragilis group isolates collected from 17 centers in Argentina during the period from 2006 to 2009 were as follows: piperacillin-tazobactam, 99%; ampicillin-sulbactam, 92%; ..
  98. pmc Bacteroides in the infant gut consume milk oligosaccharides via mucus-utilization pathways
    Angela Marcobal
    Department of Microbiology and Immunology, Stanford School of Medicine, CA 94305, USA
    Cell Host Microbe 10:507-14. 2011
    ..We determined that the prominent neonate gut residents, Bacteroides thetaiotaomicron and Bacteroides fragilis, induce the same genes during HMO consumption that are used to ..
  99. doi Bacteroides reticulotermitis sp. nov., isolated from the gut of a subterranean termite (Reticulitermes speratus)
    Mitsuo Sakamoto
    Microbe Division Japan Collection of Microorganisms, RIKEN BioResource Center, Tsukuba, Ibaraki 305 0074, Japan
    Int J Syst Evol Microbiol 63:691-5. 2013
    ..Phylogenetic analyses based on 16S rRNA gene sequences showed that strain Rs-03(T) was a member of the genus Bacteroides and was most closely related to Bacteroides thetaiotaomicron JCM 5827(T) (95...
  100. ncbi Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease
    Hiromasa Takaishi
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Int J Med Microbiol 298:463-72. 2008
    ..Crohn's disease (CD) were analyzed by quantitative PCR using 16S rRNA gene-targeted group-specific primers for Bacteroides fragilis group, Bifidobacterium, Clostridium coccoides groups, Clostridium leptum subgroup, Atopobium cluster, ..
  101. pmc Loss of NHE3 alters gut microbiota composition and influences Bacteroides thetaiotaomicron growth
    Melinda A Engevik
    Dept of Molecular and Cellular Physiology, Univ of Cincinnati College of Medicine, Cincinnati, OH 45267
    Am J Physiol Gastrointest Liver Physiol 305:G697-711. 2013
    ..b>Bacteroides thetaiotaomicron (B...

Research Grants66

  1. CONTROL OF PERIODONTAL INFECTIONS
    Sigmund Socransky; Fiscal Year: 2003
    ..One complex, determined the "red complex," consisting of Bacteroides forsythus, Porphyromonas gingivalis and Treponema denticola appears to be a major etiologic contributor to the ..
  2. Regulation of Bacteroides fragilis multidrug efflux pumps
    Hannah Wexler; Fiscal Year: 2013
    ..Significance: Bacteroides fragilis are ubiquitous gut commensals that cause devastating disease when they escape the gut;their resistance ..
  3. Defining evolutionary trajectories: Molecular adaptation to antibiotic resistance
    ADIL YOUSIF SHAMOO; Fiscal Year: 2012
    ..The target genes for study are E. faecalis Tn916 tetM (ribosomal protection against tetracyclines), Bacteroides Tn4400 tetX (enzymatic inactivation of tetracyclines) and TnA TEM-1 (enzymatic inactivation of (-lactams)...
  4. ROLE OF B.FRAGILIS OXYGEN STRESS RESPONSE IN INFECTION
    Charles J Smith; Fiscal Year: 2013
    ..These infections are composed of mixed intestinal flora with the indigenous intestinal anaerobe, Bacteroides fragilis as the predominant component...
  5. Mechanisms of Interleukin-17 Inflammation Induced by Bacteroides fragilis
    CYNTHIA SEARS; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Bacteroides fragilis are common colonic commensals, known to occupy a mucosal niche in the colon and the leading anaerobe in human disease. One class of B...
  6. Phenotype MicroArray Analysis of Fastidious Pathogens
    Barry Bochner; Fiscal Year: 2009
    ..Helicobacter, Campylobacter, Arcobacter, Wolinella), and important colonizers of the colon and vagina (Bacteroides, Clostridium, Lactobacillus, Escherichia)...
  7. Diagnostic tools to link Bacteroides fragilis toxin isotypes and human disease
    Saraspadee Mootien; Fiscal Year: 2012
    ..research is to develop a series of diagnostic assays that will detect specific types of enterotoxigenic Bacteroides fragilis (ETBF). ETBF has been shown to cause diarrhea as well as bowel inflammation and colitis...
  8. Tannerella forsythia intercations with host cells and other bacteria
    Ashu Sharma; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Tannerella forsythia (Bacteroides forsythus) is a gram-negative oral anaerobe implicated in the development of periodontal disease pathogenesis. T...
  9. Role of Innate Immunity and Stat3 Activation in Colitis Mouse Model
    SHERVIN RABIZADEH; Fiscal Year: 2013
    ..b>Bacteroides fragilis is a common human commensal residing in the colon. A subset of B. fragilis, enterotoxigenic B...
  10. Commensal Bacteroides signal through sphingolipid rafts during intestinal stress
    Dennis L Kasper; Fiscal Year: 2012
    ..The genus Bacteroides is a major bacterial component of the GI tract and is rarely found elsewhere...
  11. Mucosal Immune Ontogeny and Intestinal Microbiota in Infants
    Edward N Janoff; Fiscal Year: 2010
    ..Breastfeeding limits the complexity of the GI microbiota. Colonizing bacteria (e.g., Bacteroides and Clostridium species) are implicated in driving the development and diversity of the immunoglobulin genes ..
  12. Impact of Diet on Intestinal Microbiota-Host Dynamics
    Justin Sonnenburg; Fiscal Year: 2013
    ..Species of abundant gut-dwelling bacteria, such as Bacteroides thetaiotaomicron (B...
  13. Sugar Regulation of EHEC virulence
    Vanessa Sperandio; Fiscal Year: 2013
    ..During growth in mucus, the glycophagic prominent member of the GI microbiota, Bacteroides thetaiotaomicron, supplies fucose to EHEC, modulating its virulence gene expression...
  14. Corrinoid Response of the Human Gut Microbiota
    Andrew L Goodman; Fiscal Year: 2013
    ..Aim 1 will determine the response of a prominent human gut symbiont (Bacteroides thetaiotaomicron) to exogenous corrinoids...
  15. Epithelial Glycoconjugates as Barriers against Enteric Infections
    Nicholas J Mantis; Fiscal Year: 2013
    ..We have shown that colonization of adult germ-free (gnotobiotic) with the commensal Bacteroides thetaiotaomicron induces a mature pattern by up-regulating enterocyte-specific expression of a 1,2 ..
  16. ROLE OF B.FRAGILIS OXYGEN STRESS RESPONSE IN INFECTION
    Charles Smith; Fiscal Year: 2009
    ..These infections are composed of mixed intestinal flora with the indigenous intestinal anaerobe, Bacteroides fragilis as the predominant component...
  17. The role of polyamine oxidase in antitumor drug response
    Robert A Casero; Fiscal Year: 2013
    ..epithelial cell typesby multiple stimuli including Helicobacter pylori infection, exposure to Enterotoxigenic Bacteroides fragilis (ETBF), and exposure to the general mediators of inflammation, TNF[unreadable], IL-1[unreadable] IL-6, ..
  18. Toxin-Associated Oxidative DNA Damage Initiates Tumor-Specific Epigenetic Changes
    HEATHER M O'HAGAN; Fiscal Year: 2013
    ..Here we use exposure to toxigenic bacteria, enterotoxigenic Bacteroides fragilis (ETBF), which is known to be associated with acute and chronic colitis and colon cancer in humans, to ..
  19. Diversity-Generation and Variable Protein Displays in Pathogens and Phage
    Jeffery F Miller; Fiscal Year: 2013
    ..to health and disease, DGRs are present as chromosomal elements in human commensals including members of the Bacteroides, Bifid bacterium, Eubacterium and Ruminococcus genera, and they are also encoded by pathogens such as ..
  20. The role of polysaccharide surface capsules in Bacteroides glycan degradation
    Eric C Martens; Fiscal Year: 2013
    ..We have shown that CPS expression in the abundant human gut symbiont Bacteroides thetaiotaomicron (Bt) is coordinated with expression of some Sus- like systems involved in degrading host-..
  21. Complex glycan utilization by human gut Bacteroides
    Eric C Martens; Fiscal Year: 2013
    ..b>Bacteroides thetaiotaomicron {B...
  22. GALT mediated protection against CNS demyelination: Role of commensal bacteria
    Lloyd H Kasper; Fiscal Year: 2012
    ..characterized preparation of the bacterial antigen, polysaccharide A (PSA) derived from the human commensal Bacteroides fragilis can protect against EAE in an IL-10 dependent mechanism...
  23. Aerobic Growth of Anaerobic Pathogens
    ABRAHAM LINCOLN SONENSHEIN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Two very different bacterial pathogens, the Gram-negative Bacteroides fragilis and the Gram-positive Clostridium difficile, have been considered as textbook examples of strict anaerobes that inhabit ..
  24. Small non-coding RNAs in Porphyromonas gingivalis
    JANINA P contact LEWIS; Fiscal Year: 2010
    ..organisms we predict that this work will shed light on the mechanisms of sncRNA-mediated regulation in other Bacteroides-related bacteria such as Prevotella intermedia, Tannerella forsythensis, Bacteroides fragilis, B...
  25. Genomic and metabolomic foundations of human-microbial symbiosis in the gut
    JEFFREY IVAN GORDON; Fiscal Year: 2013
    ..We have used germ-free (GF) mice colonized with Bacteroides thetaiotaomicron (B...
  26. Diversity-Generating Retroelements in Phage and Bacterial Genomes
    Jeffery F Miller; Fiscal Year: 2010
    ..Of particular note are DGRs that are predicted to diversify proteins on the surface of Bacteroides thetaiotaomicron, one of the most abundant members of the gastrointestinal flora, and Treponema denticola, an ..
  27. ANALYSES OF SITE-SPECIFIC RECOMBINATION
    Jeffrey F Gardner; Fiscal Year: 2013
    ..CTnDOT resides in the chromosomes of clinically important Bacteroides strains. It carries genes encoding resistances to the antibiotics tetracycline and erythromycin...
  28. Adaptive Immune Response to Symbiotic Bacteria as a Mediator of Gut Homeostasis
    Daniel A Peterson; Fiscal Year: 2010
    ..microbiota in gnotobiotic Rag1-/- mice, where the diversity of the gut microbiota is reduced to one species (Bacteroides thetaiotaomicron, a prominent sequenced member of the normal human gut microbiota), and the repertoire of the ..
  29. Investigating the Gut Microbiome for Novel Therapies and Diagnostics for Autism
    Paul H Patterson; Fiscal Year: 2013
    ..Furthermore, we show that administration of a probiotic bacterium, Bacteroides fragilis, to these mice cures several behavioral abnormalities while restoring GI barrier function...
  30. Protection from Mucosal Pathology by Gut Microbiota during Colitis
    Sarkis K Mazmanian; Fiscal Year: 2013
    ..Our laboratory has described a leading model system for studying beneficial host-bacterial symbiosis. Bacteroides fragilis, a common member of the human microbiome, ameliorates gut inflammation and treats experimental colitis...
  31. Antigenic Carbohydrate Structure, Function, and Specificity
    Brian A Cobb; Fiscal Year: 2013
    ..b>Bacteroides fragilis is one such probiotic by virtue of the immunomodulatory properties of its capsular polysaccharide PSA, ..
  32. Biosynthesis of the Immunomodulatory Molecule Capsular Polysaccharide A
    Jerry M Troutman; Fiscal Year: 2012
    ..of this proposal is on capsular polysaccharide A expressed on the cell surface of the symbiotic prokaryote Bacteroides Fragilis...
  33. Impact of Oral bacterial interactions on periodontitis
    Eric Reynolds; Fiscal Year: 2004
    ..Three bacterial species (Porphyromonas gingivalis, Treponema denticola, Bacteroides forsythus) have been shown to be closely associated with chronic periodontitis in humans, and a commensal oral ..
  34. Enterotoxigenic Bacteroides fragilis: A bacterial promoter of colon oncogenesis
    CYNTHIA SEARS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We have identified a human colon anaerobic bacterium, enterotoxigenic Bacteroides fragilis (ETBF), as a candidate etiologic agent for colon cancer and our murine models of ETBF colonization delineate ..
  35. Significance of Bacteroides fragilis polysaccharide phase variation
    Laurie E Comstock; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Bacteroides are one of the numerically dominant genera of the human intestinal microbiota where they are mutualistic symbionts providing beneficial properties to humans...
  36. DEFINING HOST-MICROBIAL INTERACTIONS THAT TRIGGER INFLAMMATORY BOWEL DISEASE
    Thaddeus S Stappenbeck; Fiscal Year: 2013
    ..We previously established Koch's postulates for a specific bacterial species, Bacteroides thetaiotaomicron (B. theta) in the dnKO mouse model of colitis, by colonization of antibiotic pre-treated mice...
  37. Bacteriocins of the Intestinal Bacteroidales
    Laurie E Comstock; Fiscal Year: 2013
    ..b>Bacteroides spp...
  38. CONJUGAL TRANSFER OF BACTERIODES ANTIBIOTIC RESISTANCES
    Abigail A Salyers; Fiscal Year: 2011
    b>Bacteroides species are Gram-negative obligate anaerobes that account for 20-30% of the bacterial population that normally inhabits the human colon...
  39. ANTIBIOTIC SUSCEPTIBILITIES OF PERIODONTAL BACTERIA
    Clay Walker; Fiscal Year: 1993
    ..B-lactamase enzymes produced by periodontal strains of Bacteroides intermedius and Eikenella corrodens will be characterized to determine if differences exist in the enzymes ..
  40. Antigenic variation by multiple promoter inversions in Mycoplasma penetrans
    Michael Calcutt; Fiscal Year: 2009
    ..is unprecedented in mycoplasmas and greatly exceeds the largest reported prokaryotic system of 13 segments in Bacteroides fragilis...
  41. IN SITU ANALYSIS OF HUMAN PLAQUE FORMATION
    Greg Germaine; Fiscal Year: 1991
    ..will be prepared against oral Streptococcus, Actinomyces, Veillonella, Lactobacillus, Neisseria, Hemophilus, Bacteroides, Fusobacterium, Capnocytophaga, Actinobacillus and Treponena...
  42. The Microbiota in a Novel Mouse Model of Ulcerative Colitis
    Daniel A Peterson; Fiscal Year: 2013
    ..We will examine gut microbes that are known to be able to degrade mucus (Bacteroides thetaiotaomicronsm, Akkermansia muciniphila, Ruminococcus gnavus, and R...
  43. Defining How The Intestinal Microbiota Responds to Pathogen-Induced Inflammation
    Rachel Taylor; Fiscal Year: 2013
    ..Genetic manipulation of the model gut mutualist Bacteroides thetaiotaomicron will be combined with in vivo approaches that utilize gnotobiotic mice colonized with defined ..
  44. GPR35: Role in Colonic Inflammation and Oncogenesis
    CYNTHIA SEARS; Fiscal Year: 2013
    ..The human colon anaerobic bacterium, enterotoxigenic Bacteroides fragilis (ETBF), is a molecular subtype of B...
  45. BACTERIAL INDUCED COLITIS IN HLA-B27 RATS
    LEVINUS DIELEMAN; Fiscal Year: 2002
    ..colitis, gastritis and arthritis when raised in specific pathogen-free environment or when colonized with Bacteroides vulgatus, but which have no clinical or histological disease when raised in a sterile environment or ..
  46. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 2010
    ..b>Bacteroides fragilis are common colonic commensals (up to 70% of adults colonized) and the leading anaerobe in human ..
  47. NON-INVASIVE ASSESSMENT OF PERIODONTAL DISEASE ACTIVITY
    CHRISTINE NIEKRASH; Fiscal Year: 1990
    ..The titer of gingival fluid and serum antibodies specifically reactive with three target microorganisms (Bacteroides gingivalis, Capnocytophaga sputigena, and Fusobacterium nucleatum) associated with the induction of ..
  48. Molecular Mechanisms that Shape Gut Microbial Communities
    Sarkis K Mazmanian; Fiscal Year: 2013
    ..b>Bacteroides are one of the most numerically prominent and biologically important genera in the human microbiota...
  49. Mechanisms of TH17 Inflammation-Induced Colon Carcihogenesis
    CYNTHIA SEARS; Fiscal Year: 2013
    ..We have identified a human colon anaerobic bacterium, enterotoxigenic Bacteroides fragilis (ETBF), that induces a rapid and dramatic increase in colon tumors in multiple intestinal neoplasia ..
  50. GENETIC STUDY OF PROTEASES IN BACTEROIDES GINGIVALIS
    Jeffrey Felton; Fiscal Year: 1991
    ..The long-term objectives of the proposed study are to characterize several putative virulence factors produced by Bacteroides gingivalis (B.g...
  51. Quorum Sensing in the Commensal Bacterium Bacteroides fragilis
    ANISA SALIM ISMAIL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Quorum sensing in the commensal bacterium Bacteroides fragilis Intestinal epithelial cells provide the crucial interface (400 m2) between mammalian hosts and a vast consortium of microbial partners...
  52. BACTEROIDES FRAGILIS CAPSULES--SYNTHESIS AND VIRULENCE
    Arthur Tzianabos; Fiscal Year: 1999
    ..This research will expand our understanding of how bacteria promote abscess formation in the peritoneal cavity and may lead to better therapeutic measures to prevent or treat this disease process. ..
  53. LPS-MONOCYTE INTERACTIONS IN PERIODONTAL DISEASE
    Frank Nichols; Fiscal Year: 1990
    ..greater than or equal to Salmonella typhimurium greater than Actinobacillus actinomycetemcomintans greater than Bacteroides intermedius greater than B. gingivalis...
  54. Exploring the mechanisms of T cell intrinsic TLR2 signaling on Treg function
    JUNE LOUISE ROUND; Fiscal Year: 2013
    ..Sarkis K. Mazmanian. Dr. Round's research utilizes the commensal organism, Bacteroides fragilis, as a model bacterial organism to study commensal-host relationships...
  55. T CELL REGULATION OF CARIES IMMUNITY/PERIODONTAL DISEASE
    Hiroshi Kiyono; Fiscal Year: 1992
    ..For example, polyclonal and antigen-specific immune responses to periodontopathoges, e.g., Bacteroides gingivalis (Bg) and Haemophilis actinomycetemcomitans (Ha) play important roles in the development of gingival ..
  56. EFFECT OF LASER RADIATION ON PERIODONTOPATHIC BACTERIA
    CLAY HENRY; Fiscal Year: 1990
    ..prevent periodontal-diseases in humans by means of laser radiation directed specifically toward black-pigmented Bacteroides, the strongly implicated causative agent...
  57. PERIODONTOPATHIC BACTERIA--CHEMICAL-BIOLOGIC NATURE
    STANLEY HOLT; Fiscal Year: 1992
    ..Among these, members of the genera Bacteroides, Actinobacillus, Wolinella, Eikenella, and Capnocytophaga are important contributors to periodontal ..
  58. EFFECT OF ANTAGONISM AND S-IGA INDIGENOUS ANAEROBES
    RODNEY BERG; Fiscal Year: 1980
    ..A gnotobiotic mouse model has been developed demonstrating bacterial antagonism of an oxygen-sensitive Bacteroides sp. by oxygen-sensitive Eubacterium sp. and Fusobacterium sp...
  59. INTERACTION OF ORAL BACTERIA WITH PERIODONTAL TISSUES
    Jorgen Slots; Fiscal Year: 1990
    ..and electron microscopy to learn more about the importance of Actinobacillus actin omycetemcomitans, Bacteroides gingivalis and Bacteroides intermedius in adult periodontitis...
  60. THE BACTEROIDES FORSYTHUS GENOME PROJECT
    Steven Gill; Fiscal Year: 2001
    ..We will also work closely with those investigators developing a specific Oral Pathogens database to make our data and analysis available. ..
  61. HOST-BACTERIAL INTERACTIONS IN PERIODONTAL DISEASE
    RUSSELL NISENGARD; Fiscal Year: 1992
    ..Previous studies have demonstrated that immunization with heat killed Bacteroides macacae provides some protection in the ligature induced periodontitis model by reducing both the ..
  62. Oral Pathogens: Polymicrobial Virulence Interactions
    KESAVALU LAKSHMYYA; Fiscal Year: 2006
    ..in a majority of adult periodontitis patients consists of Porphyromonas gingivalis, TannereIla forsythensis [Bacteroides forsythus], and Treponema denticola...
  63. Analysis innate immune responses to oral pathogens
    Marcia McInerney; Fiscal Year: 2003
    ..Major pathogens associated with periodontitis are Porphyromonas gingivalis (P. gingivalis), Bacteroides forsythus (B. forsythus) and Treponema denticola (T. denticola), all Gram-negative anaerobes...
  64. Genetic System to Study Virulence in Bacteroides
    Michael Malamy; Fiscal Year: 2003
    ..We will develop additional tools to define changes in macromolecular synthesis and stability of DNA, proteins and membranes during 9 oxygen challenge. ..
  65. CLONING BACTEROIDES GINGIVALIS COLLAGENASE
    Virginia Clark; Fiscal Year: 1991
    ..The anaerobic oral bacterium, Bacteroides gingivalis, which had been implicated as a major pathogen in adult periodontitis, produces collagenase, while ..
  66. The role of iron/heme acquisition mechanisms in Bacteroides fragilis.
    EDSON ROCHA; Fiscal Year: 2009
    The colonization of the human colon by Bacteroides spp...