trypanosomatina

Summary

Summary: A suborder of monoflagellate parasitic protozoa that lives in the blood and tissues of man and animals. Representative genera include: Blastocrithidia, Leptomonas, CRITHIDIA, Herpetomonas, LEISHMANIA, Phytomonas, and TRYPANOSOMA. Species of this suborder may exist in two or more morphologic stages formerly named after genera exemplifying these forms - amastigote (LEISHMANIA), choanomastigote (CRITHIDIA), promastigote (Leptomonas), opisthomastigote (Herpetomonas), epimastigote (Blastocrithidia), and trypomastigote (TRYPANOSOMA).

Top Publications

  1. pmc Characterization of glycosomal RING finger proteins of trypanosomatids
    Tracy Saveria
    Seattle Biomedical Research Institute, 307 Westlake Avenue N, Seattle, WA 98109, USA
    Exp Parasitol 116:14-24. 2007
  2. ncbi Developmental regulation of gene expression in trypanosomatid parasitic protozoa
    Simon Haile
    Research Centre in Infectious Diseases, CHUL Research Centre of Laval University, CHUQ, 2705 Laurier Blvd, Quebec, QC, Canada G1V 4G2
    Curr Opin Microbiol 10:569-77. 2007
  3. ncbi Phylogenetic validation of the genera Angomonas and Strigomonas of trypanosomatids harboring bacterial endosymbionts with the description of new species of trypanosomatids and of proteobacterial symbionts
    Marta M G Teixeira
    Department of Parasitology, ICB, University of Sao Paulo USP, Sao Paulo, 05508 000, SP, Brazil
    Protist 162:503-24. 2011
  4. pmc Identification and phylogenetic analysis of heme synthesis genes in trypanosomatids and their bacterial endosymbionts
    João M P Alves
    Department of Microbiology and Immunology and the Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 6:e23518. 2011
  5. ncbi Trypanosomatid biodiversity in Costa Rica: genotyping of parasites from Heteroptera using the spliced leader RNA gene
    S J Westenberger
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1487, USA
    Parasitology 129:537-47. 2004
  6. ncbi Cysteine peptidases in the tomato trypanosomatid Phytomonas serpens: influence of growth conditions, similarities with cruzipain and secretion to the extracellular environment
    Camila G R Elias
    Laboratorio de Estudos Integrados em Bioquimica Microbiana, Departamento de Microbiologia Geral, IMPPG, CCS, Bloco I subsolo, Universidade Federal do Rio de Janeiro UFRJ, Cidade Universitaria, Rio de Janeiro, RJ, Brazil
    Exp Parasitol 120:343-52. 2008
  7. ncbi Probing into the diversity of trypanosomatid flagellates parasitizing insect hosts in South-West China reveals both endemism and global dispersal
    Jan Votypka
    Biology Centre, Institute of Parasitology, Ceské Budejovice Budweis, Czech Republic
    Mol Phylogenet Evol 54:243-53. 2010
  8. ncbi Insect trypanosomatids: the need to know more
    S A Podlipaev
    Zoological Institute, Russian Academy of Sciences, St Petersburg
    Mem Inst Oswaldo Cruz 95:517-22. 2000
  9. ncbi Phytomonas serpens: cysteine peptidase inhibitors interfere with growth, ultrastructure and host adhesion
    Andre L S Santos
    Departamento de Microbiologia Geral, Instituto de Microbiologia Prof Paulo de Góes IMPPG, Universidade Federal do Rio de Janeiro UFRJ, Ilha do Fundao, Cidade Universitaria, Rio de Janeiro, RJ, 21941 590, Brazil
    Int J Parasitol 36:47-56. 2006
  10. ncbi The more insect trypanosomatids under study-the more diverse Trypanosomatidae appears
    S Podlipaev
    Zoological Institute Russian Academy of Sciences, 199034, St Petersburg, Russia
    Int J Parasitol 31:648-52. 2001

Research Grants

  1. Comparative Analysis of Editosome in Trypanosomatids
    Reza Salavati; Fiscal Year: 2003
  2. Development of Assay for High Throughput Screen of Parasite Glucose Transporter
    Scott M Landfear; Fiscal Year: 2010
  3. Biochemical and Functional Analysis of Trypanin
    KENT HILL; Fiscal Year: 2007
  4. Mitochondrial dynamics and assembly in yeast
    Robert Jensen; Fiscal Year: 2008
  5. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
  6. RNA as the catalyst for screening drugs against trypanosomatids
    Reza Salavati; Fiscal Year: 2006
  7. LSM 510 Confocal Microscope
    Robert Jensen; Fiscal Year: 2004
  8. PROTEIN IMPORT INTO YEAST MITOCHONDRIA
    Robert Jensen; Fiscal Year: 2004
  9. DRUG RESISTANCE AND PTERIDINE METABOLISM IN LEISHMANIA
    Stephen M Beverley; Fiscal Year: 2010
  10. The contractile vacuole of Trypanosoma cruzi
    Roberto Docampo; Fiscal Year: 2010

Detail Information

Publications169 found, 100 shown here

  1. pmc Characterization of glycosomal RING finger proteins of trypanosomatids
    Tracy Saveria
    Seattle Biomedical Research Institute, 307 Westlake Avenue N, Seattle, WA 98109, USA
    Exp Parasitol 116:14-24. 2007
    ..GFP fusions of T. cruzi PEX10 and L. major PEX12 also localized to glycosomes in T. brucei indicating that glycosomal membrane protein targeting is conserved across trypanosomatids...
  2. ncbi Developmental regulation of gene expression in trypanosomatid parasitic protozoa
    Simon Haile
    Research Centre in Infectious Diseases, CHUL Research Centre of Laval University, CHUQ, 2705 Laurier Blvd, Quebec, QC, Canada G1V 4G2
    Curr Opin Microbiol 10:569-77. 2007
    ..Several of these developments have greatly benefited from the recently completed genomic sequences and functional genomic studies...
  3. ncbi Phylogenetic validation of the genera Angomonas and Strigomonas of trypanosomatids harboring bacterial endosymbionts with the description of new species of trypanosomatids and of proteobacterial symbionts
    Marta M G Teixeira
    Department of Parasitology, ICB, University of Sao Paulo USP, Sao Paulo, 05508 000, SP, Brazil
    Protist 162:503-24. 2011
    ..The congruence of the phylogenetic trees of trypanosomatids and their symbionts support a co-divergent host-symbiont evolutionary history...
  4. pmc Identification and phylogenetic analysis of heme synthesis genes in trypanosomatids and their bacterial endosymbionts
    João M P Alves
    Department of Microbiology and Immunology and the Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 6:e23518. 2011
    ..Our evidence suggests that this synergistic relationship is the end result of a history of extensive gene loss and multiple lateral gene transfer events in different branches of the phylogeny of the Trypanosomatidae...
  5. ncbi Trypanosomatid biodiversity in Costa Rica: genotyping of parasites from Heteroptera using the spliced leader RNA gene
    S J Westenberger
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1487, USA
    Parasitology 129:537-47. 2004
    ..This study reveals only a minor fraction of the trypanosomatid biodiversity, which is anticipated to be high...
  6. ncbi Cysteine peptidases in the tomato trypanosomatid Phytomonas serpens: influence of growth conditions, similarities with cruzipain and secretion to the extracellular environment
    Camila G R Elias
    Laboratorio de Estudos Integrados em Bioquimica Microbiana, Departamento de Microbiologia Geral, IMPPG, CCS, Bloco I subsolo, Universidade Federal do Rio de Janeiro UFRJ, Cidade Universitaria, Rio de Janeiro, RJ, Brazil
    Exp Parasitol 120:343-52. 2008
    ..The 40kDa peptidase was also detected in the cell-free culture supernatant, in an active form, which suggests secretion of this peptidase to the extracellular environment...
  7. ncbi Probing into the diversity of trypanosomatid flagellates parasitizing insect hosts in South-West China reveals both endemism and global dispersal
    Jan Votypka
    Biology Centre, Institute of Parasitology, Ceské Budejovice Budweis, Czech Republic
    Mol Phylogenet Evol 54:243-53. 2010
    ..Moreover, phylogenetic analysis revealed the presence, among the isolated strains, of a new Phytomonas species, which is the first documentation of this potentially pathogenic dixenous parasite of plants in China...
  8. ncbi Insect trypanosomatids: the need to know more
    S A Podlipaev
    Zoological Institute, Russian Academy of Sciences, St Petersburg
    Mem Inst Oswaldo Cruz 95:517-22. 2000
    ..The remaining genera that comprise parasites associated with insects have been largely neglected except for two or three containing popular isolates. This publication reviews current knowledge of trypanosomatids from insects...
  9. ncbi Phytomonas serpens: cysteine peptidase inhibitors interfere with growth, ultrastructure and host adhesion
    Andre L S Santos
    Departamento de Microbiologia Geral, Instituto de Microbiologia Prof Paulo de Góes IMPPG, Universidade Federal do Rio de Janeiro UFRJ, Ilha do Fundao, Cidade Universitaria, Rio de Janeiro, RJ, 21941 590, Brazil
    Int J Parasitol 36:47-56. 2006
    ..Collectively, these results suggest that cysteine peptidases participate in several biological processes in P. serpens including cell growth and interaction with the invertebrate vector...
  10. ncbi The more insect trypanosomatids under study-the more diverse Trypanosomatidae appears
    S Podlipaev
    Zoological Institute Russian Academy of Sciences, 199034, St Petersburg, Russia
    Int J Parasitol 31:648-52. 2001
    ..Therefore, the more insect trypanosomatids are involved in laboratory investigations--the more new clusters or/and new lineages are appearing on the tree...
  11. ncbi Insights into the role of gp63-like proteins in lower trypanosomatids
    Claudia Masini d'Avila-Levy
    Departamento de Microbiologia Geral, Instituto de Microbiologia Prof Paulo de Goes, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    FEMS Microbiol Lett 254:149-56. 2006
    ..aegypti gut wall. In addition, our results indicate for the first time that the gp63-like molecule binds to a polypeptide of 50 kDa on the A. aegypti gut epithelium extract...
  12. ncbi Discovery and barcoding by analysis of spliced leader RNA gene sequences of new isolates of Trypanosomatidae from Heteroptera in Costa Rica and Ecuador
    Dmitri A Maslov
    Department of Biology, University of California, Riverside, California 92521, USA
    J Eukaryot Microbiol 54:57-65. 2007
    ..Investigations of trypanosomatid diversity, host-specificity, and biogeography have become feasible using the approach described herein...
  13. ncbi Protective immunity against Trypanosoma cruzi provided by oral immunization with Phytomonas serpens: role of nitric oxide
    P Pinge-Filho
    Department of Pathological Sciences, State University of Londrina, CEP 86051 970, Parana, Brazil
    Immunol Lett 96:283-90. 2005
    ..These results suggest that protective immunity against T. cruzi infection induced by immunization with P. serpens is dependent upon enhanced NO production during the acute phase of T. cruzi infection...
  14. ncbi Phytomonas serpens, a tomato parasite, shares antigens with Trypanosoma cruzi that are recognized by human sera and induce protective immunity in mice
    José Wander Breganó
    Laboratório de Tripanosomatídeos, Centro de Ciencias Biologicas, Universidade Estadual de Londrina, Parana, Brazil
    FEMS Immunol Med Microbiol 39:257-64. 2003
    ..cruzi antigens and interfere with the development of T. cruzi infection...
  15. ncbi Identification, molecular and functional characterization of calmodulin gene of Phytomonas serpens 15T that shares high similarity with its pathogenic counterparts Trypanosoma cruzi
    Tatiana de Arruda Campos Brasil de Souza
    Departamento de Microbiologia, Centro de Ciencias Biologicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, PR 445, Km 380, Londrina, Paraná CEP 86051 980, Brazil
    Protein J 30:212-9. 2011
    ..A polyclonal antiserum raised against the recombinant protein recognized a polypeptide with an estimated size of 17 kDa in log-phase promastigote extracts. The recombinant CaMP retains its Ca²+-binding capacity...
  16. ncbi Endosymbiosis in protozoa of the Trypanosomatidae family
    W De Souza
    Laboratorio de Ultraestrutura Celular Hertha Meyer, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil
    FEMS Microbiol Lett 173:1-8. 1999
    ..The results obtained show that endosymbiont-containing species of trypanosomatids constitute an excellent model to study basic processes on the endosymbiont-host cell relationship and the origin of new organelles...
  17. ncbi Influence of the endosymbiont of Blastocrithidia culicis and Crithidia deanei on the glycoconjugate expression and on Aedes aegypti interaction
    Claudia M d'Avila-Levy
    Departamento de Microbiologia Geral, Instituto de Microbiologia Prof Paulo de Góes IMPPG, Centro de Ciencias da Saude CCS, Universidade Federal do Rio de Janeiro UFRJ, Bloco I, Ilha do Fundao, Brazil
    FEMS Microbiol Lett 252:279-86. 2005
    ..Collectively, our results suggest a possible involvement of sialomolecules and mannose-rich glycoconjugates in the interaction between insect trypanosomatids and the invertebrate host...
  18. ncbi Colonization of Aedes aegypti midgut by the endosymbiont-bearing trypanosomatid Blastocrithidia culicis
    Miguel S Corrêa-da-Silva
    Laboratorio de Ultraestrutura Celular Hertha Meyer, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS, Blogo G, subsolo, Ilha do Fundao, 21 941 900, Rio de Janeiro, RJ, Brazil
    Parasitol Res 99:384-91. 2006
    ..By demonstrating B. culicis colonization in a bloodsucking insect, we suggest that vector transmission of monoxenous trypanosomatids to vertebrate host may occur in nature...
  19. ncbi Rational sub-division of plant trypanosomes (Phytomonas spp.) based on minicircle conserved region analysis
    Nancy R Sturm
    CIRAD, UPR29 Etiologie Dépérissements, Département Systèmes Biologiques, TA A 29 F, Campus International de Baillarguet, 34398 Montpellier Cedex 5, France
    Infect Genet Evol 7:570-6. 2007
    ..The remainder of the isolates fell into a heterogeneous cluster. At least eight different groups in the plant trypanosomatids were identified...
  20. ncbi Diversity and phylogeny of insect trypanosomatids: all that is hidden shall be revealed
    Dmitri A Maslov
    Department of Biology, University of California, Riverside, CA 92521, USA
    Trends Parasitol 29:43-52. 2013
    ..Although more than 100 typing units have been discovered recently, these appear to represent a small segment of trypanosomatid biodiversity, which still remains to be uncovered...
  21. pmc Isolation of a protozoan parasite genetically related to the insect trypanosomatid Herpetomonas samuelpessoai from a human immunodeficiency virus-positive patient
    Florent Morio
    Department of Parasitology, French National Reference Centre on Leishmaniasis, 163 rue Auguste Broussonnet, 34090 Montpellier, France
    J Clin Microbiol 46:3845-7. 2008
    ..Here we report the first isolation of a flagellated protozoan genetically closely related to Herpetomonas samuelpessoai, which is usually a parasite of insects, from the blood of an HIV-infected patient...
  22. ncbi Peptidases and gp63-like proteins in Herpetomonas megaseliae: possible involvement in the adhesion to the invertebrate host
    Ana C Nogueira de Melo
    Departamento de Microbiologia Geral, Instituto de Microbiologia Prof Paulo de Góes IMPPG, Universidade Federal do Rio de Janeiro UFRJ, Cidade Universitaria, Ilha do Fundao, Rio de Janeiro, RJ 21941 590, Brazil
    Int J Parasitol 36:415-22. 2006
    ..Collectively, these results corroborate the ubiquitous existence of gp63 homologues in insect trypanosomatids and the potential adhesion of these molecules to invertebrate host tissues...
  23. ncbi Cosmopolitan distribution of a trypanosomatid Leptomonas pyrrhocoris
    Jan Votypka
    Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic
    Protist 163:616-31. 2012
    ..sp. with an overlapping host range has been described. Moreover, 10 typing units of trypanosomatids found in the pyrrhocorid hosts demonstrate the extent of variability of trypanosomatids occurring in one host family...
  24. ncbi Interaction of the monoxenic trypanosomatid Blastocrithidia culicis with the Aedes aegypti salivary gland
    Michelle Tanny C Nascimento
    Laboratório de Imunobiologia das Leishmanioses, Departamento de Imunologia, Instituto de Microbiologia Prof Paulo de Goes, Universidade Federal do Rio de Janeiro, RJ, Brazil
    Acta Trop 113:269-78. 2010
    ..These results suggest that salivary gland invasion could be part of the B. culicis life cycle in A. aegypti, raising the possibility that B. culicis can be transmitted by these mosquitoes...
  25. ncbi Phylogenetic relationships of trypanosomatids parasitising true bugs (Insecta: Heteroptera) in sub-Saharan Africa
    Jan Votypka
    Biology Centre, Institute of Parasitology, Czech Academy of Sciences, Branisovska 31, 370 05 Ceské Budejovice Budweis, Czech Republic
    Int J Parasitol 42:489-500. 2012
    ..The analysis presented significantly extends the known diversity of monoxenous insect trypanosomatids and will be instrumental in building a new taxonomy that reflects their true phylogenetic relationships...
  26. ncbi Trypanosomatid prevalence and host habitat choice in woodland Drosophila
    M A Ebbert
    Department of Zoology, Miami University, Oxford, Ohio 45056, USA
    J Invertebr Pathol 77:27-32. 2001
    ..Prevalence was highest in the most abundant species, members of the subgenus Sophophora, species using decaying fruit as breeding sites, and those able to use more than one type of substrate for oviposition...
  27. ncbi The evolution and diversity of kinetoplastid flagellates
    Alastair G B Simpson
    Canadian Institute for Advanced Research and Department of Biology, Dalhousie University, Halifax, Canada, B3H 4J1
    Trends Parasitol 22:168-74. 2006
    ..The framework of relationships is becoming robust enough for real comparative approaches to be used to understand kinetoplastid biology...
  28. ncbi Searching the Tritryp genomes for drug targets
    Peter J Myler
    Seattle Biomedical Research Institute, 307 Westlake Ave N, Suite 500, Seattle, Washington 98109 5219, USA
    Adv Exp Med Biol 625:133-40. 2008
    ..This vast amount of information now makes possible several new approaches for target identification and ushers in a post-genomic era for trypanosomatid drug discovery...
  29. ncbi Ovothiol and trypanothione as antioxidants in trypanosomatids
    M R Ariyanayagam
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, DD 1 5EH, Scotland, Dundee, UK
    Mol Biochem Parasitol 115:189-98. 2001
    ..Nonetheless, since ovothiol is absent in host macrophage, kidney and CHO cells, this metabolite may have other important functional roles in trypanosomatids that could be exploited as a chemotherapeutic target...
  30. ncbi Effects of sterol biosynthesis inhibitors on endosymbiont-bearing trypanosomatids
    Isabella Vieira Palmié-Peixoto
    Laboratorio de Ultraestrutura Celular Hertha Meyer, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    FEMS Microbiol Lett 255:33-42. 2006
    ....
  31. pmc Trypanothione S-transferase activity in a trypanosomatid ribosomal elongation factor 1B
    Tim J Vickers
    Division of Biological Chemistry and Molecular Microbiology, The Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 279:27246-56. 2004
    ..Two eEF1Bgamma genes were cloned from C. fasciculata, but recombinant C. fasciculata eEF1Bgamma had no S-transferase activity, suggesting that eEF1Bgamma is unstable in the absence of the other subunits...
  32. ncbi Interaction of insect trypanosomatids with mosquitoes, sand fly and the respective insect cell lines
    Patrícia Fampa
    Departamento de Imunologia, Instituto de Microbiologia Prof Paulo de Góes Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Int J Parasitol 33:1019-26. 2003
    ..Endosymbiont-bearing trypanosomatids were able to colonise Aedes aegypti guts after protozoa feeding...
  33. ncbi Complex I of Trypanosomatidae: does it exist?
    Fred R Opperdoes
    de Duve Institute and Université catholique de Louvain, Avenue Hippocrate 74, Brussels, Belgium
    Trends Parasitol 24:310-7. 2008
    ....
  34. pmc Complement interaction with trypanosomatid promastigotes in normal human serum
    Mercedes Dominguez
    Servicio de Inmunologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, E 28220 Madrid, Spain
    J Exp Med 195:451-9. 2002
    ..5 min of serum contact. These data indicate that successful Leishmania infection in man must immediately follow promastigote transmission, and that Leishmania evasion strategies are shaped by the selective pressure exerted by complement...
  35. ncbi Leptomonas costaricensis sp. n. (Kinetoplastea: Trypanosomatidae), a member of the novel phylogenetic group of insect trypanosomatids closely related to the genus Leishmania
    V Y Yurchenko
    Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    Parasitology 133:537-46. 2006
    ..This tree topology supports the hypothesis that the initial transition to dixenous parasitism in this group pre-dated the continental split and that afterwards the Neotropical and the Old World groups evolved largely independently...
  36. ncbi The trypanosomatid signal recognition particle consists of two RNA molecules, a 7SL RNA homologue and a novel tRNA-like molecule
    Li Liu
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Biol Chem 278:18271-80. 2003
    ..The discovery of sRNA-85 raises the intriguing possibility that sRNA-85 functional homologues may exist in other lower eukaryotes and eubacteria that lack the Alu domain...
  37. ncbi Selective recovery of the cultivation-prone components from mixed trypanosomatid infections: a case of several novel species isolated from Neotropical Heteroptera
    Vyacheslav Y Yurchenko
    Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Int J Syst Evol Microbiol 59:893-909. 2009
    ..The properties of the new organisms, including their morphology and ultrastructure, as well as their phylogenetic affinities within the family, were investigated and used to describe five novel species...
  38. pmc Secretory pathway of trypanosomatid parasites
    Malcolm J McConville
    Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia
    Microbiol Mol Biol Rev 66:122-54; table of contents. 2002
    ..They also reveal unusual or novel aspects of secretory transport and protein glycosylation that may be exploited in developing new antiparasite drugs...
  39. ncbi The microtubule analog protein, FtsZ, in the endosymbiont of trypanosomatid protozoa
    Maria Cristina M Motta
    Instituto de Biofisica Carlos Chagas Filho, Laboratorio de Ultraestrutura Celular Hertha Meyer, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    J Eukaryot Microbiol 51:394-401. 2004
    ..The sequences obtained from the endosymbionts from C. deanei and B. culicis were very similar, and were most closely related to bacteria from the genus Pseudomonas...
  40. ncbi Protozomics: trypanosomatid parasite genetics comes of age
    Stephen M Beverley
    Department of Molecular Microbiology, Washington University Medical School, St Louis, Missouri 63110, USA
    Nat Rev Genet 4:11-9. 2003
    ..Interestingly, the efficacy of different genetic tools has steered research into different aspects of the biology of these parasites...
  41. pmc Down-regulation of the trypanosomatid signal recognition particle affects the biogenesis of polytopic membrane proteins but not of signal peptide-containing proteins
    Yaniv Lustig
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Eukaryot Cell 6:1865-75. 2007
    ..Our results demonstrate that, as in bacteria but in contrast to mammalian cells, the trypanosome SRP is mostly essential for the biogenesis of membrane proteins...
  42. ncbi Small nucleolar RNA clusters in trypanosomatid Leptomonas collosoma. Genome organization, expression studies, and the potential role of sequences present upstream from the first repeated cluster
    Xue Hai Liang
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Biol Chem 279:5100-9. 2004
    ....
  43. ncbi The kinetoplast ultrastructural organization of endosymbiont-bearing trypanosomatids as revealed by deep-etching, cytochemical and immunocytochemical analysis
    Danielle Pereira Cavalcanti
    Laboratorio de Ultraestrutura Celular Hertha Meyer, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro UFRJ, Centro de Ciencias da Saude, Bloco G, subsolo, Rio de Janeiro, RJ, Brazil
    Histochem Cell Biol 130:1177-85. 2008
    ..The kinetoplast structural organization of Bodo sp. was also analyzed, since this protozoan lacks the highly ordered kDNA-packaging characteristic of trypanosomatid and represents an evolutionary ancestral of the Trypanosomatidae family...
  44. ncbi Gene synteny and evolution of genome architecture in trypanosomatids
    Elodie Ghedin
    Parasity Genomics, The Institute for Genomics Research, 9712 Medical Center Dr Rockville, MD 20850, USA
    Mol Biochem Parasitol 134:183-91. 2004
    ..major by examining the regions near breakage points of the synteny. This is the first such element found in L. major suggesting that retroelements were found in the common ancestor of all three species...
  45. pmc Comparative analysis of editosome proteins in trypanosomatids
    Elizabeth A Worthey
    Seattle Biomedical Research Institute, Seattle, WA 98109, USA
    Nucleic Acids Res 31:6392-408. 2003
    ..These domains are generally conserved within other protein families, but some are found in novel combinations in the editosome proteins...
  46. ncbi Diversity of insect trypanosomatids assessed from the spliced leader RNA and 5S rRNA genes and intergenic regions
    Sergei A Podlipaev
    Institute of Parasitology, Czech Academy of Sciences, Ceske Budejovice, Czech Republic
    J Eukaryot Microbiol 51:283-90. 2004
    ..Our data revealed additional discrepancies between molecular phylogenetic data and cell morphology, rendering current trypanosomatid taxonomy unreliable...
  47. ncbi Conserved repeats in the kinetoplast maxicircle divergent region of Leishmania sp. and Leptomonas seymouri
    Pavel N Flegontov
    Department of Molecular Biology, Lomonosov Moscow State University, Vorobjevy Gory 1, build 12, 119992, Moscow, Russia
    Mol Genet Genomics 276:322-33. 2006
    ..collosoma, and T. cruzi have a completely different DR structure. Identification of conserved sequences and invariable structural features of the DR may further our understanding of the functioning of this important genome fragment...
  48. ncbi Differential detection of Blastocrithidia triatomae and Trypanosoma cruzi by amplification of 24salpha ribosomal RNA genes in faeces of sylvatic triatomine species from rural northwestern Argentina
    A G Schijman
    Laboratorio de Biologia Molecular de la Enfermedad de Chagas, Instituto de Ingeniería Genética y Biología Molecular INGEBI CONICET, Buenos Aires, Argentina
    Acta Trop 99:50-4. 2006
    ..This PCR procedure provides a rapid sensitive tool for differential diagnosis of morphologically similar trypanosomatids in field surveys of Chagas disease vectors and laboratory-reared triatomines used for xenodiagnosis...
  49. ncbi [ATPase subunit 6 gene of Leptomonas seymouri (Trypanosomatidae) is transcribed and edited as a polycistronic transcript]
    E A Bessolitsyna
    Mol Biol (Mosk) 39:61-6. 2005
    ..Based on the analysis of two fully edited A6 transcripts we propose the existence of two alternatively edited products...
  50. pmc Chemical synthesis and binding activity of the trypanosomatid cap-4 structure
    Magdalena Lewdorowicz
    Department of Biophysics, Institute of Experimental Physics, Warsaw University, 93 Zwirki and Wigury St, 02 089, Poland
    RNA 10:1469-78. 2004
    ..Biological activity of this newly synthesized compound was confirmed in binding studies with eIF4E from Leishmania that we recently cloned (LeishIF4E-1), using the fluorescence time-synchronized titration method...
  51. ncbi The structure and replication of kinetoplast DNA
    Joseph Shlomai
    Department of Parasitology, The Kuvin Center for the Study of Infectious and Tropical Diseases, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Curr Mol Med 4:623-47. 2004
    ..In this review I describe the recent advances in the study of kDNA and discuss some of the major challenges in deciphering the structure, replication and segregation of this remarkable DNA structure...
  52. ncbi An updated view of kinetoplastid phylogeny using environmental sequences and a closer outgroup: proposal for a new classification of the class Kinetoplastea
    David Moreira
    UMR CNRS 8079, Ecologie, Systematique et Evolution, Universite Paris Sud, Batiment 360, 91405 Orsay Cedex, France
    Int J Syst Evol Microbiol 54:1861-75. 2004
    ..The classification of the species formerly included in the genus Bodo is also revised, with the amendment of this genus and the genus Parabodo and the creation of a new genus, Neobodo...
  53. ncbi An integrated morphological and molecular approach to a new species description in the Trypanosomatidae: the case of Leptomonas podlipaevi n. sp., a parasite of Boisea rubrolineata (Hemiptera: Rhopalidae)
    Vyacheslav Yurchenko
    Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, New York 1046 USA
    J Eukaryot Microbiol 53:103-11. 2006
    ..Molecular phylogenetic analysis has demonstrated that the new species is most closely related to Leptomonas seymouri and Leptomonas pyrrhocoris. The analysis has also highlighted the polyphyly of the genus Leptomonas...
  54. ncbi Identification of endotrypanum species from a sloth, a squirrel and Lutzomyia sandflies in ecuador by PCR amplification and sequencing of the mini-exon gene
    Ken Katakura
    Department of Parasitology, Gunma University School of Medicine, Maebashi, Japan
    J Vet Med Sci 65:649-53. 2003
    ....
  55. ncbi Immunocytochemical detection of DNA and RNA in endosymbiont-bearing trypanosomatids
    Maria Cristina M Motta
    Laboratorio de Ultraestrutura Celular Hertha Meyer, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS, Bloco G, Ilha do Fundao, 21940 900 Rio de Janeiro, RJ, Brazil
    FEMS Microbiol Lett 221:17-23. 2003
    ....
  56. ncbi Chemotherapeutic approaches to protozoa: kinetoplastida--current level of knowledge and outlook
    A Harder
    Animal Health Business Group, Research and Development, Biological and Chemical Evaluation, Leverkusen, Germany
    Parasitol Res 87:778-80. 2001
    ..1999). Two drugs are currently used against Chagas' disease, although these do not cure chronic effects. There is no prospect of novel drugs in this indication either (Pecoul et al. 1999; Morel 2000)...
  57. pmc Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design
    J C Bressi
    Department of Chemistry, University of Washington, Seattle, WA 98195, USA
    J Med Chem 44:2080-93. 2001
    ..We also explored adenosine analogues containing 5'-amido substituents and found that 2',5'-dideoxy-2'-(3,5-dimethoxybenzamido)-5'-(diphenylacetamido)adenosine (49) displays an IC(50) of 60-100 microM against the three parasite GAPDH's...
  58. ncbi Cytokinesis in trypanosomatids
    Tansy C Hammarton
    Wellcome Centre for Molecular Parasitology, University of Glasgow, 120 University Place, Glasgow G12 8TA, United Kingdom
    Curr Opin Microbiol 10:520-7. 2007
    ..In this review, we discuss direct and indirect effects on cytokinesis, using Trypanosoma brucei as a model...
  59. ncbi Sergeia podlipaevi gen. nov., sp. nov. (Trypanosomatidae, Kinetoplastida), a parasite of biting midges (Ceratopogonidae, Diptera)
    Milena Svobodova
    Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic
    Int J Syst Evol Microbiol 57:423-32. 2007
    ..An unrelated insect species, Culicoides (Monoculicoides) nubeculosus, was experimentally infected with S. podlipaevi, demonstrating that its host range extends to different subgenera of biting midges...
  60. pmc Atypical processing in domain III of 23S rRNA of Rhizobium leguminosarum ATCC 10004(T) at a position homologous to an rRNA fragmentation site in protozoa
    Franziska Klein
    Institut für Mikrobiologie und Molekularbiologie der Justus Liebig Universität Giessen, 35392 Giessen, Germany
    J Bacteriol 184:3176-85. 2002
    ..6-kb rRNA fragments during the first hours after inoculation, which points to changes in the ratio of rRNA synthesis rate to domain III processing rate during the growth of a culture...
  61. ncbi Phylogeny of Trypanosomatidae and Bodonidae (Kinetoplastida) based on 18S rRNA: evidence for paraphyly of Trypanosoma and six other genera
    Austin L Hughes
    Department of Biological Sciences, University of South Carolina, USA
    Mol Biol Evol 20:644-52. 2003
    ..The results suggested that parasitism of vertebrates has probably arisen independently a number of times within the Trypanosomatidae...
  62. pmc Trypanosome spliced leader RNA genes contain the first identified RNA polymerase II gene promoter in these organisms
    G Gilinger
    Department of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Nucleic Acids Res 29:1556-64. 2001
    ..We show here that the in vitro transcription extract contains a binding activity that is specific for the initiator element and thus may participate in recruiting RNA polymerase II to the SL RNA gene promoter...
  63. pmc The spliced leader-associated RNA is a trypanosome-specific sn(o) RNA that has the potential to guide pseudouridine formation on the SL RNA
    Xue Hai Liang
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    RNA 8:237-46. 2002
    ..This study solves a long-standing question regarding the function of this novel RNA and describes the first H/ACA RNA, which, unlike all other pseudouridine guides, is also a bona fide snRNA...
  64. ncbi Trypanosoma evansi: cloning and expression in Spodoptera frugiperda [correction of fugiperda] insect cells of the diagnostic antigen RoTat1.2
    T Urakawa
    International Livestock Research Institute, ILRI, Nairobi, Kenya
    Exp Parasitol 99:181-9. 2001
    ..With the recombinant RoTat1.2 at hand, it is now possible to investigate the extent to which epitopes on this VSG are conserved among different T. evansi isolates...
  65. ncbi A postgenomic view of the heat shock proteins in kinetoplastids
    Cristina Folgueira
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Madrid, Spain
    FEMS Microbiol Rev 31:359-77. 2007
    ..All these families are widely represented in these parasites. In particular, kinetoplastids possess an unprecedented number of members of the HSP70, HSP60 and HSP40 families, suggesting key roles for these HSPs in their biology...
  66. ncbi Trypanosoma cruzi oleate desaturase: molecular characterization and comparative analysis in other trypanosomatids
    Rosa A Maldonado
    Department of Biological Sciences, University of Texas at El Paso, 500 W University Ave, El Paso, Texas 79968, USA
    J Parasitol 92:1064-74. 2006
    ..amazonensis, H. megaseliae, and L. seymouri. The fact that the enzyme oleate desaturase is not present in humans makes it an ideal molecular target for the development of new chemotherapeutic approaches against Chagas disease...
  67. ncbi Application of multiple DNA fingerprinting techniques to study the genetic relationships among three members of the subgenus Trypanozoon (Protozoa: Trypanosomatidae)
    Feng Jun Li
    State Key Laboratory of Biocontrol, School of Life Sciences, Center for Parasitic Organisms, Sun Yat Sen Zhongshan University, Guangzhou 510275, People s Republic of China
    Mol Cell Probes 19:400-7. 2005
    ..brucei. The findings provide support for the hypothesis that T. evansi originated from a mutated form of T. equiperdum and stimulate further investigations of the genetic make-up and evolution of members of the subgenus Trypanozoon...
  68. ncbi Telomere biology of trypanosomatids: beginning to answer some questions
    Cristina B B Lira
    Laboratório de Telômeros, Departamento de Genetica, Instituto de Biociencias, Universidade Estadual Paulista Julio de Mesquita Filho UNESP, Botucatu, SP, Brazil
    Trends Parasitol 23:357-62. 2007
    ..Because telomere maintenance mechanisms are essential for genome stability, we propose that the particular features shown by the trypanosome telomeric chromatin hold the key for the design of antiparasitic drugs...
  69. pmc Mitochondrial localization of the mevalonate pathway enzyme 3-Hydroxy-3-methyl-glutaryl-CoA reductase in the Trypanosomatidae
    Javier Pena-Diaz
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, 18001 Granada, Spain
    Mol Biol Cell 15:1356-63. 2004
    ....
  70. ncbi Phytomonas serpens: immunological similarities with the human trypanosomatid pathogens
    Andre L S Santos
    Departamento de Microbiologia Geral, Instituto de Microbiologia Prof Paulo de Góes IMPPG, Centro de Ciencias da Saude CCS, Bloco I, Universidade Federal do Rio de Janeiro UFRJ, RJ 21941 590, Brazil
    Microbes Infect 9:915-21. 2007
    ..cruzi, this plant trypanosomatid may be a suitable candidate for vaccine studies. Moreover, comparative approaches in the Trypanosomatidae family may be useful to understand kinetoplastid biology, biochemistry and evolution...
  71. ncbi The mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase of Trypanosomatidae and the glycosomal redox balance of insect stages of Trypanosoma brucei and Leishmania spp
    Daniel G Guerra
    Research Unit for Tropical Diseases, Christian de Duve Institute of Cellular Pathology and Laboratory of Biochemistry, Universite Catholique de Louvain, ICP TROP 74 39, Avenue Hippocrate 74, B 1200 Brussels, Belgium
    Mol Biochem Parasitol 149:155-69. 2006
    ....
  72. ncbi Revisiting the directional mutation pressure theory: the analysis of a particular genomic structure in Leishmania major
    Anamaria Necsulea
    Laboratoire de Biométrie et Biologie Évolutive UMR 5558, CNRS, Univ Lyon, Villeurbanne Cedex, France
    Gene 385:28-40. 2006
    ..We conclude that the particular case of L. major should lead to a careful reevaluation of several hypotheses of this theory. The origin of the negative GC12/GC3 correlation remains for now an open question...
  73. ncbi Targeting glycoproteins or glycolipids and their metabolic pathways for antiparasite therapy
    Sumi Mukhopadhyay Nee Bandyopadhyay
    Immunobiology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700 032, India
    Adv Exp Med Biol 625:87-102. 2008
    ..This review intends to focus on such lines, which will give us an insight into the future hope for development of novel therapeutic strategies through glycobiological platform for combating kinetoplastid infections...
  74. pmc Biology and mechanism of trypanosome cell motility
    Kent L Hill
    Department of Microbiology, University of California at Los Angeles, Los Angeles, California 90095, USA
    Eukaryot Cell 2:200-8. 2003
  75. ncbi A PCR-based survey on Phytomonas (Euglenozoa: Trypanosomatidae) in phytophagous hemipterans of the Amazon region
    Mara M I Godoi
    Federal University of Rondĵnia, Department of Biomedical Science, Porto Velho, Brazil
    J Eukaryot Microbiol 49:275-9. 2002
    ..Since many Phytomonas are pathogenic in plants, this high prevalence in their vectors emphasizes the permanent risk of exposure to disease by native and cultured plants of the Amazon region...
  76. ncbi Herpetomonas spp. isolated from tomato fruits (Lycopersicon esculentum) in southern Spain
    Clotilde Marín
    Instituto de Biotecnologia, Departamento de Parasitologia, Facultad de Ciencias, Universidad de Granada, C Severo Ochoa s n 18071 Granada, Spain
    Exp Parasitol 116:88-90. 2007
    ..The DNA sequence was obtained and its alignment with other trypasomatids, obtained using the BLAST algorithm, suggested it was closely related to Herpetomonas samuelpessoai...
  77. ncbi Isoenzyme clustering of Trypanosomatidae Colombian populations
    Marleny M Montilla
    Instituto Nacional de Salud, Laboratorio de Parasitologia, Bogota, Colombia
    Am J Trop Med Hyg 66:394-400. 2002
    ..Since, the upper level of resolution of the isoenzyme method was exceeded, the current clustering study failed to draw a clear distinction between such a diverse set of Trypanosomatidae species...
  78. ncbi Extracellular release of the surface metalloprotease, gp63, from Leishmania and insect trypanosomatids
    Charles L Jaffe
    Cell Biology Section, Div of Intramural Research, NIAID, NIH, Bethesda, MD 20892, USA
    Parasitol Res 91:229-37. 2003
    ....
  79. pmc Identification of mRNA decapping activities and an ARE-regulated 3' to 5' exonuclease activity in trypanosome extracts
    Joseph Milone
    Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey New Jersey Medical School, International Center for Public Health, 225 Warren Street, Newark, NJ 07103, USA
    Nucleic Acids Res 30:4040-50. 2002
    ..Importantly, this exonuclease activity was stimulated by an AU-rich element present in the RNA. In summary, the cell-free system has defined several RNA turnover steps that likely contribute to regulated mRNA decay in trypanosomes...
  80. ncbi Environmental kinetoplastid-like 18S rRNA sequences and phylogenetic relationships among Trypanosomatidae: paraphyly of the genus Trypanosoma
    Helen Piontkivska
    Department of Biological Sciences, 242 Cunningham Hall, Kent State University, Kent OH 44242, USA
    Mol Biochem Parasitol 144:94-9. 2005
    ..brucei (cause of African sleeping sickness) are not as closely related to each other as they were previously thought to be. Likewise, the results did not support monophyly of the genera Leishmania, Leptomonas, Bodo and Cryptobia...
  81. ncbi Development of symbionts in triatomine bugs and the effects of infections with trypanosomatids
    S Eichler
    Department of Special Zoology, Ruhr University, D 44780 Bochum, Germany
    Exp Parasitol 100:17-27. 2002
    ..rangeli and B. triatomae for R. prolixus and T. infestans, respectively, that the primal point of attack is the host-specific symbiont, R. rhodnii and Nocardia sp., respectively...
  82. ncbi [Rupestrian triatomines infected by Trypanosomatidae, collected in Quaraí, Rio Grande do Sul, 2003]
    Luciamare Perinetti Alves Martins
    Faculdade de Medicina de Marilia, Marilia, SP, Brazil
    Rev Soc Bras Med Trop 39:198-202. 2006
    ..Of these triatomines, 4 (30.8%) displayed no reagent precipitin for the antiserum tested, 4 (30.8%) were positive for rodent antiserum, 4 (30.8%) were positive for goat antiserum and 1 (7.7%) were positive for human and pig antiserum...
  83. pmc Protein kinases as drug targets in trypanosomes and Leishmania
    Christina Naula
    Wellcome Centre for Molecular Parasitology, The Anderson College, 56 Dumbarton Road, University of Glasgow, Glasgow G11 6NU, UK
    Biochim Biophys Acta 1754:151-9. 2005
    ..In this review, we examine the prospects for exploiting differences between parasite and mammalian protein kinases to develop novel anti-parasitic chemotherapeutic agents...
  84. ncbi Comparison and evolutionary analysis of the glycosomal glyceraldehyde-3-phosphate dehydrogenase from different Kinetoplastida
    V Hannaert
    Research Unit for Tropical Diseases, Christian de Duve Institute of Cellular Pathology ICP, and Laboratory of Biochemistry, Catholic University of Louvain, Brussels, Belgium
    J Mol Evol 47:728-38. 1998
    ..The division of the Kinetoplastida into two suborders, Bodonina and Trypanosomatina, was well supported...
  85. ncbi Phylogeny of the kinetoplastida: taxonomic problems and insights into the evolution of parasitism
    D A Maslov
    Department of Biology, University of California, Riverside, CA 92521, USA
    Mem Inst Oswaldo Cruz 96:397-402. 2001
    ..The suborder Trypanosomatina appeared as a monophyletic group, while the suborder Bodonina was paraphyletic...
  86. ncbi Phylogenetic position of the kinetoplastids, Cryptobia bullocki, Cryptobia catostomi, and Cryptobia salmositica and monophyly of the genus Trypanosoma inferred from small subunit ribosomal RNA sequences
    A D Wright
    Department of Zoology, University of Guelph, Ont, Canada
    Mol Biochem Parasitol 99:69-76. 1999
    ..kinetoplastids are a monophyletic group divided into two major lineages consistent with the two suborders, Trypanosomatina and Bodonina...
  87. ncbi Drugs and transporters in kinetoplastid protozoa
    Scott M Landfear
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Adv Exp Med Biol 625:22-32. 2008
    ..A summary of recent work on Leishmania transporters for glucose and for purines is provided as an example of permeases that are being studied in molecular detail...
  88. pmc Identification of specific inhibitors for a trypanosomatid RNA editing reaction
    Shuang Liang
    Department of Pharmacology, Medical School, University of Minnesota, Minneapolis, Minnesota 55455, USA
    RNA 16:2435-41. 2010
    ..Since protoporphyrin IX and sphingosine are both naturally present within the trypanosomatids, their effectiveness as in vitro inhibitors is also suggestive of the potential for in vivo modulatory roles...
  89. ncbi [Trypanosomatid (Protozoa, Kinetoplastida) parasites of sloths (Mannmalia, Xenarthra)]
    B Rotureau
    Laboratoire Hospitalo universitaire de Parasitologie et Mycologie Médicale, Equipe EA 3593, UFR de Médecine de l Université des Antilles et de la Guyane, Campus St Denis, BP 718, 97300 Cayenne, Guyane Francaise
    Bull Soc Pathol Exot 99:171-5. 2006
    ..The improvement of the preventive method efficacy against synanthropozoonotic diseases due to several of these protozoa relies on studies on the ecology and biology of wild reservoir hosts such as sloths...
  90. ncbi The Leishmania major maxicircle divergent region is variable in different isolates and cell types
    Pavel N Flegontov
    Department of Molecular Biology, Moscow State University, Russia
    Mol Biochem Parasitol 146:173-9. 2006
    ..major isolates by PCR and demonstrated its great variability. We suppose, however, that different variants of the DR structure are generated by combination of several highly conserved domains...
  91. pmc Detection of Leptomonas sp. parasites in clinical isolates of Kala-azar patients from India
    Pankaj Srivastava
    Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, UP, India
    Infect Genet Evol 10:1145-50. 2010
    ..and L. donovani in this isolate. We consider that mixed infection may be present in the patients themselves, Leptomonas persisting in them because of the immuno-suppression associated with Kala-azar...
  92. ncbi Redescription of Trypanosoma ophiocephali Chen 1964 (Kinetoplastida: Trypanosomatina: Trypanosomatidae) and first record from the blood of dark sleeper (Odontobutis obscura Temminck and Schlegel) in China
    Zemao Gu
    Laboratory of Healthy Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, People s Republic of China
    Parasitol Res 100:149-54. 2006
    ..Infection with trypanosomes of O. obscura was recorded for the first time. According to the size and appearance, the trypanosomes in O. obscura were also tentatively identified as T. ophiocephali Chen 1964...
  93. ncbi Genomics, pathogenesis and control of infection with protozoan parasites
    Santuza M R Teixeira
    Dept of Biochemistry and Immunology, Federal University of Minas Gerais, Av Antonio Carlos 6627, 31270 901, MG, Belo Horizonte, Brazil
    Trends Parasitol 18:52-4. 2002
  94. ncbi Morphological, biochemical and molecular characterization of Herpetomonas samuelpessoai camargoi n. subsp., a trypanosomatid isolated from the flower of the squash Cucurbita moschata
    J E Fiorini
    , Unifenas, Alfenas, MG, Brazil
    J Eukaryot Microbiol 48:62-9. 2001
    ..subsp. is proposed...
  95. ncbi On the role of exon and intron sequences in trans-splicing utilization and cap 4 modification of the trypanosomatid Leptomonas collosoma SL RNA
    Michal Mandelboim
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Biol Chem 277:35210-8. 2002
    ..This study, however, did not provide support for the putative SL RNA-U6 small nuclear RNA (snRNA) interaction at the Sm site like in the nematodes, suggesting differences in the bridging role of U6 in the two trans-splicing systems...
  96. ncbi The acidocalcisome
    R Docampo
    Laboratory of Molecular Parasitology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA
    Mol Biochem Parasitol 114:151-9. 2001
    ..The acidocalcisome is possibly involved in polyphosphate and cation storage and in adaptation of these microoganisms to environmental stress...
  97. ncbi Bisphosphonates as chemotherapeutic agents against trypanosomatid and apicomplexan parasites
    R Docampo
    Laboratory of Molecular Parasitology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA
    Curr Drug Targets Infect Disord 1:51-61. 2001
    ....
  98. ncbi Cell fractionation of parasitic protozoa: a review
    Wanderley de Souza
    Laboratorio de Ultraestrutura Celular Hertha Meyer, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941 900, Brasil
    Mem Inst Oswaldo Cruz 98:151-70. 2003
    ....
  99. pmc Cloning and characterization of a gene encoding an immunoglobulin-binding receptor on the cell surface of some members of the family Trypanosomatidae
    Antonio Campos-Neto
    Infectious Disease Research Institute, Seattle, Washington, USA
    Infect Immun 71:5065-76. 2003
    ....
  100. ncbi Trypanosomatid histones
    Sam Alsford
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Mol Microbiol 53:365-72. 2004
    ....
  101. ncbi Purification and characterization of two iron superoxide dismutases of Phytomonas sp. isolated from Euphorbia characias (plant trypanosomatids)
    C Marin
    Instituto de Biotecnologia, Facultad de Ciencias, Universidad de Granada, c Severo Ochoa s n, 18071 Granada, Spain
    Parasitology 129:79-86. 2004
    ....

Research Grants19

  1. Comparative Analysis of Editosome in Trypanosomatids
    Reza Salavati; Fiscal Year: 2003
    ..These analyses will be useful for understanding the function of the editosome and its components and also for development of drugs that could be effective for all three species. ..
  2. Development of Assay for High Throughput Screen of Parasite Glucose Transporter
    Scott M Landfear; Fiscal Year: 2010
    ..Since glucose is an essential nutrient for these parasites, such compounds would kill the parasite and could act as novel drugs for treatment of the diseases they cause. ..
  3. Biochemical and Functional Analysis of Trypanin
    KENT HILL; Fiscal Year: 2007
    ..Therefore, in addition to addressing fundamental questions in cell biology, this research directly impacts efforts to understand and treat infectious diseases and genetic diseases in humans. ..
  4. Mitochondrial dynamics and assembly in yeast
    Robert Jensen; Fiscal Year: 2008
    ..of mitochondrial protein import, and how is it related tomitochondrial shape? [unreadable] 3) What is the mechanism of mitochondrial division? [unreadable] 4) What is the mechanism of mitochondrial fusion? [unreadable] [unreadable]..
  5. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  6. RNA as the catalyst for screening drugs against trypanosomatids
    Reza Salavati; Fiscal Year: 2006
    ..They will also contribute to development of drugs against trypanosomatids. ..
  7. LSM 510 Confocal Microscope
    Robert Jensen; Fiscal Year: 2004
    ..The application is supported by a broad base of interest, need, and financial support by the university and will serve a large NIH-funded scientific community. ..
  8. PROTEIN IMPORT INTO YEAST MITOCHONDRIA
    Robert Jensen; Fiscal Year: 2004
    ..docking role in the insertion process? (4) What is the precise pathway that proteins traverse during their import and insertion into the inner membrane? (5) Can inner membrane protein insertion be reconstituted using purified components? ..
  9. DRUG RESISTANCE AND PTERIDINE METABOLISM IN LEISHMANIA
    Stephen M Beverley; Fiscal Year: 2010
    ..These studies have yielded new opportunities for chemotherapeutic attack and new directions for future study of pteridine metabolism and biology. [unreadable] ..
  10. The contractile vacuole of Trypanosoma cruzi
    Roberto Docampo; Fiscal Year: 2010
    ..cruzi. Specific aim 2: To identify the molecular mechanism involved in the traffic T. cruzi aquaporin to the contractile vacuole complex and the role of aquaporin in regulatory volume decrease. ..
  11. Transcription of protein-coding genes in Leishmania
    PETER JOHN MYLER; Fiscal Year: 2010
    ..In this proposal, we will test this hypothesis and build on our current work to further characterize the chromatin-modifying enzymes that are involved in transcription initiation. ..
  12. Functional Characterization of Leishmania Transporters
    Scott M Landfear; Fiscal Year: 2010
    ..Overall, this proposal will provide a detailed biochemical and genetic dissection of glucose transporter function and the essential role of these permeases in the parasite life cycle. ..
  13. Antigen Detection Assay for Tuberculosis
    Antonio Campos Neto; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  14. VACCINE DEVELOPMENT IN TUBERCULOSIS
    Antonio Campos Neto; Fiscal Year: 2004
    ..In addition to the evaluation of these antigens, we will characterize and clone other vaccine candidates using recently developed approaches for the direct identification of both CD4 and CD8 T cell antigens. ..
  15. EGSi, A Tool for Gene Inactivation in Trypanosomatids
    Reza Salavati; Fiscal Year: 2004
    ..abstract_text> ..
  16. ACIDOCALCISOMES IN TRYPANOSOMA CRUZI
    Roberto Docampo; Fiscal Year: 2003
    ..cruzi, especially the role of acidocalcisomes and the contractile vacuole; Specific aim 2, Investigation of the role of acidocalcisome polyP in osmoregulation. ..
  17. A NOVEL MICROTUBULE-ASSOCIATED PROTEIN IN TRYPANOSOMES
    KENT HILL; Fiscal Year: 2002
    ....
  18. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  19. ACIDOCALCISOMES IN TRYPANOSOMA CRUZI
    Roberto Docampo; Fiscal Year: 2002
    ..cruzi H+-pyrophosphatase; specific aim 3: investigation of the role of acidocalcisomes in intracellular Ca2+ and pH homeostasis. ..