plasmodium yoelii

Summary

Summary: A species of PLASMODIUM causing malaria in rodents.

Top Publications

  1. pmc Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites
    Noah S Butler
    Department of Microbiology, University of Iowa, 3 512 Bowen Science Building, Iowa City, IA 52242, USA
    Cell Host Microbe 9:451-62. 2011
  2. pmc The oligomerization domain of C4-binding protein (C4bp) acts as an adjuvant, and the fusion protein comprised of the 19-kilodalton merozoite surface protein 1 fused with the murine C4bp domain protects mice against malaria
    Solabomi A Ogun
    Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Infect Immun 76:3817-23. 2008
  3. pmc Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity
    Nathan W Schmidt
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 186:5873-84. 2011
  4. pmc A dispensable Plasmodium locus for stable transgene expression
    Vanessa Y Jacobs-Lorena
    Seattle Biomedical Research Institute, Seattle, WA 98109 5219, USA
    Mol Biochem Parasitol 171:40-4. 2010
  5. pmc Plasmodium falciparum homologue of the genes for Plasmodium vivax and Plasmodium yoelii adhesive proteins, which is transcribed but not translated
    H M Taylor
    National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Infect Immun 69:3635-45. 2001
  6. pmc Single amino acid substitution in Plasmodium yoelii erythrocyte ligand determines its localization and controls parasite virulence
    Hitoshi Otsuki
    Department of Molecular Parasitology, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Proc Natl Acad Sci U S A 106:7167-72. 2009
  7. ncbi Vaccination with live Plasmodium yoelii blood stage parasites under chloroquine cover induces cross-stage immunity against malaria liver stage
    Elodie Belnoue
    Department of Immunology, Centre National de la Recherche Scientifique, Institut Cochin, Universite Paris Descartes, Paris, France
    J Immunol 181:8552-8. 2008
  8. ncbi A critical role for phagocytosis in resistance to malaria in iron-deficient mice
    Chikako Matsuzaki-Moriya
    Department of Microbiology and Immunology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Immunol 41:1365-75. 2011
  9. pmc Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery
    Stephan Meister
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 334:1372-7. 2011
  10. pmc Phenotypic and functional profiling of malaria-induced CD8 and CD4 T cells during blood-stage infection with Plasmodium yoelii
    Anmol Chandele
    Joint ICGEB Emory Vaccine Center, Aruna Asaf Ali Marg, New Delhi, India
    Immunology 132:273-86. 2011

Detail Information

Publications254 found, 100 shown here

  1. pmc Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites
    Noah S Butler
    Department of Microbiology, University of Iowa, 3 512 Bowen Science Building, Iowa City, IA 52242, USA
    Cell Host Microbe 9:451-62. 2011
    ....
  2. pmc The oligomerization domain of C4-binding protein (C4bp) acts as an adjuvant, and the fusion protein comprised of the 19-kilodalton merozoite surface protein 1 fused with the murine C4bp domain protects mice against malaria
    Solabomi A Ogun
    Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Infect Immun 76:3817-23. 2008
    ..b>Plasmodium yoelii 19-kDa merozoite surface protein 1 (MSP1(19)) is a weak antigen, but mice vaccinated with this antigen in ..
  3. pmc Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity
    Nathan W Schmidt
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 186:5873-84. 2011
    ..Thus, both Plasmodium species and strain-specific background genes in nonhematopoietic cells determine the threshold of memory CD8 T cells required for protection...
  4. pmc A dispensable Plasmodium locus for stable transgene expression
    Vanessa Y Jacobs-Lorena
    Seattle Biomedical Research Institute, Seattle, WA 98109 5219, USA
    Mol Biochem Parasitol 171:40-4. 2010
    ..subunit locus has been used for transgene expression in the rodent malaria parasites, Plasmodium berghei and Plasmodium yoelii, but this strategy utilizes single crossover integration and is thus prone to reversion by plasmid excision...
  5. pmc Plasmodium falciparum homologue of the genes for Plasmodium vivax and Plasmodium yoelii adhesive proteins, which is transcribed but not translated
    H M Taylor
    National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Infect Immun 69:3635-45. 2001
    The 235-kDa family of rhoptry proteins in Plasmodium yoelii and the two reticulocyte binding proteins of P. vivax comprise a family of proteins involved in host cell selection and erythrocyte invasion...
  6. pmc Single amino acid substitution in Plasmodium yoelii erythrocyte ligand determines its localization and controls parasite virulence
    Hitoshi Otsuki
    Department of Molecular Parasitology, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Proc Natl Acad Sci U S A 106:7167-72. 2009
    The major virulence determinant of the rodent malaria parasite, Plasmodium yoelii, has remained unresolved since the discovery of the lethal line in the 1970s...
  7. ncbi Vaccination with live Plasmodium yoelii blood stage parasites under chloroquine cover induces cross-stage immunity against malaria liver stage
    Elodie Belnoue
    Department of Immunology, Centre National de la Recherche Scientifique, Institut Cochin, Universite Paris Descartes, Paris, France
    J Immunol 181:8552-8. 2008
    ..study we show that immunization of BALB/c mice with live erythrocytes infected with nonlethal strains of Plasmodium yoelii under curative chloroquine cover conferred protection not only against challenge by blood stage parasites ..
  8. ncbi A critical role for phagocytosis in resistance to malaria in iron-deficient mice
    Chikako Matsuzaki-Moriya
    Department of Microbiology and Immunology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Immunol 41:1365-75. 2011
    ..underlying the protection against malaria observed in IDA individuals using a rodent malaria parasite, Plasmodium yoelii (Py)...
  9. pmc Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery
    Stephan Meister
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 334:1372-7. 2011
    ..The open-source chemical tools resulting from our effort provide starting points for future drug discovery programs, as well as opportunities for researchers to investigate the biology of exo-erythrocytic forms...
  10. pmc Phenotypic and functional profiling of malaria-induced CD8 and CD4 T cells during blood-stage infection with Plasmodium yoelii
    Anmol Chandele
    Joint ICGEB Emory Vaccine Center, Aruna Asaf Ali Marg, New Delhi, India
    Immunology 132:273-86. 2011
    ..show that both CD8 and CD4 T cells robustly responded to an acute self-limiting blood-stage infection with Plasmodium yoelii. Similar to antigen-specific T cells, both CD8 and CD4 T cells showed dynamic expression of the surface ..
  11. pmc Immunogenicity and protective efficacy of a recombinant yellow fever vaccine against the murine malarial parasite Plasmodium yoelii
    Cristina T Stoyanov
    Laboratory of Virology and Infectious Disease, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA
    Vaccine 28:4644-52. 2010
    ..was genetically altered to express the circumsporozoite protein (CSP) from the murine malarial parasite Plasmodium yoelii. Reconstituted recombinant virus was viable and exhibited robust CSP expression...
  12. pmc In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens
    Steffen Jung
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Immunity 17:211-20. 2002
    ..e., the sensitization of the immune system for cell-associated antigens. DC-depleted mice fail to mount CTL responses to infection with the intracellular bacterium Listeria monocytogenes and the rodent malaria parasite Plasmodium yoelii.
  13. pmc Rapid changes in transcription profiles of the Plasmodium yoelii yir multigene family in clonal populations: lack of epigenetic memory?
    Deirdre Cunningham
    Division of Parasitology, National Institute for Medical Research, London, United Kingdom
    PLoS ONE 4:e4285. 2009
    ..Individual parasites of the rodent malaria Plasmodium yoelii, selected by micromanipulation, transcribe only 1 to 3 different pir (yir) suggesting tight transcriptional ..
  14. pmc IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection
    Kevin N Couper
    Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Pathog 4:e1000004. 2008
    ..regulatory T cells do not significantly influence the outcome of infections with the lethal (17XL) strain of Plasmodium yoelii (PyL)...
  15. pmc Swift development of protective effector functions in naive CD8(+) T cells against malaria liver stages
    G Sano
    Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY 10010, USA
    J Exp Med 194:173-80. 2001
    We generated T cell receptor transgenic mice specific for the liver stages of the rodent malaria parasite Plasmodium yoelii and studied the early events in the development of in vivo effector functions in antigen-specific CD8(+) T cells...
  16. pmc IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites
    Alexandre Morrot
    Department of Molecular Microbiology and Immunology, Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Exp Med 202:551-60. 2005
    IL-4 receptor (IL-4R)-deficient CD8+ T cells specific for the circumsporozoite protein of Plasmodium yoelii develop a severely impaired memory response after priming with parasites...
  17. pmc Plasmodium falciparum PF10_0164 (ETRAMP10.3) is an essential parasitophorous vacuole and exported protein in blood stages
    Drew C MacKellar
    Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109 5219, USA
    Eukaryot Cell 9:784-94. 2010
    ..PF10_0164 is refractory to disruption in asexual blood stages. Functional complementation was tested in Plasmodium yoelii by replacing the endogenous copy of UIS4 with PF10_0164...
  18. pmc Macrophage-mediated but gamma interferon-independent innate immune responses control the primary wave of Plasmodium yoelii parasitemia
    Kevin N Couper
    Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Infect Immun 75:5806-18. 2007
    ..We hypothesized therefore that the fulminant infections caused in mice by the lethal strain of Plasmodium yoelii (17XL) might be due to failure to activate a sufficient inflammatory response...
  19. ncbi Distinct host-related dendritic cell responses during the early stage of Plasmodium yoelii infection in susceptible and resistant mice
    W Zheng
    Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang, China
    Parasite Immunol 32:324-34. 2010
    ..by dendritic cells (DCs), we compared their phenotype and function during the early stages of infection with Plasmodium yoelii 17XL (P.y 17XL) strain in susceptible (BALB/c) and resistant (DBA/2) mice...
  20. pmc A systematic analysis of the early transcribed membrane protein family throughout the life cycle of Plasmodium yoelii
    Drew C MacKellar
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA, USA
    Cell Microbiol 13:1755-67. 2011
    ..Here, we comprehensively identify nine new etramps in the genome of the rodent malaria parasite Plasmodium yoelii, and elucidate their conservation in other malaria parasites...
  21. pmc Development of the malaria parasite in the skin of the mammalian host
    Pascale Gueirard
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 107:18640-5. 2010
    ..Therefore, during malaria in rodents, the skin is not just the route to the liver but is also the final destination for many inoculated parasites, where they can differentiate into merozoites and possibly persist...
  22. pmc Initiation of Plasmodium sporozoite motility by albumin is associated with induction of intracellular signalling
    Chahnaz Kebaier
    Department of Medical Parasitology, New York University School of Medicine, New York, NY 10010, USA
    Int J Parasitol 40:25-33. 2010
    ....
  23. pmc Plasmodium-induced inflammation by uric acid
    Jamie M Orengo
    Department of Medical Parasitology, New York University School of Medicine, New York, New York, USA
    PLoS Pathog 4:e1000013. 2008
    ..Identifying the mechanisms used by the parasite to induce the host inflammatory response is essential to develop urgently needed therapies against this disease...
  24. pmc VEGF promotes malaria-associated acute lung injury in mice
    Sabrina Epiphanio
    Unidade de Malaria, Instituto de Medicina Molecular, Universidade de Lisboa, Lisboa, Portugal
    PLoS Pathog 6:e1000916. 2010
    ....
  25. pmc Intradermal immunization of mice with radiation-attenuated sporozoites of Plasmodium yoelii induces effective protective immunity
    Tatiana Voza
    Department of Medical Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA
    Malar J 9:362. 2010
    ..to be unacceptable for large scale vaccination of humans, assessment was made of the results of intradermal immunization of mice with Plasmodium yoelii, a rodent malaria parasite whose infectivity resembles that of human malaria.
  26. pmc Dynamic balance of pSTAT1 and pSTAT3 in C57BL/6 mice infected with lethal or nonlethal Plasmodium yoelii
    Xibao Shi
    Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science, Guangzhou 510663, China
    Cell Mol Immunol 5:341-8. 2008
    ..of pSTAT1 and pSTAT3 in C57BL/6 mice infected with either a nonlethal (Py17XNL) or lethal (Py17XL) strain of Plasmodium yoelii. Both Py17XNL and Py17XL infections induced a maximum activation of STAT1 and STAT3 on the first day after ..
  27. ncbi An efficient strategy for gene targeting and phenotypic assessment in the Plasmodium yoelii rodent malaria model
    Sebastian A Mikolajczak
    Seattle Biomedical Research Institute, Seattle, WA 98109, USA
    Mol Biochem Parasitol 158:213-6. 2008
    In this report, we describe a cloning procedure for gene replacement by double homologous recombination in Plasmodium yoelii, which requires only one digestion and ligation step...
  28. ncbi Effect of dietary p-aminobenzoic acid on murine Plasmodium yoelii infection
    Gregory A Kicska
    Department of Biochemistry, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Infect Dis 188:1776-81. 2003
    ..We show that, despite the presence of biosynthetic machinery to synthesize PABA, Plasmodium yoelii, a rodent malaria species, requires exogenous dietary PABA for survival...
  29. ncbi Short report: modulation of Mycobacterium tuberculosis infection by Plasmodium in the murine model
    Cherise P Scott
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Trop Med Hyg 70:144-8. 2004
    ..two pathogens in vivo, we infected mice with Mycobacterium tuberculosis and then with a non-lethal strain of Plasmodium yoelii eight weeks later. Mice chronically infected with M...
  30. ncbi Plasmodium yoelii: influence of antimalarial treatment on acquisition of immunity in BALB/c and DBA/2 mice
    Shi hong Ma
    Department of Immunology, College of Basic Medical Sciences, China Medical University, Heping District, Shenyang, China
    Exp Parasitol 116:266-72. 2007
    ..BALB/c and DBA/2 mice were infected by Plasmodium yoelii 17XNL and 17XL strains, respectively, and then treated with different doses of antimalarial drugs: ..
  31. pmc Both hemolytic anemia and malaria parasite-specific factors increase susceptibility to Nontyphoidal Salmonella enterica serovar typhimurium infection in mice
    Christelle M Roux
    Department of Medical Microbiology and Immunology, University of California at Davis, Davis, California 95616, USA
    Infect Immun 78:1520-7. 2010
    ..we established a model for oral Salmonella enterica serotype Typhimurium challenge in mice infected with Plasmodium yoelii nigeriensis. Initial characterization of this model showed that 5 days after coinoculation, P...
  32. ncbi Essential role of extrathymic T cells in protection against malaria
    M Kaiissar Mannoor
    Department of Immunology, Niigata University School of Medicine, Niigata, Japan
    J Immunol 169:301-6. 2002
    ..In conjunction with the previous results in euthymic mice, the present results in athymic mice suggest that the major lymphocyte subsets associated with protection against malaria might be extrathymic T cells...
  33. ncbi Distribution and characterisation of the 235 kDa rhoptry multigene family within the genomes of virulent and avirulent lines of Plasmodium yoelii
    S M Khan
    Division of Parasitology, The National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Mol Biochem Parasitol 114:197-208. 2001
    In the rodent malaria species, Plasmodium yoelii, a multi-gene family (Py235) encodes a 235 kDa rhoptry protein. This protein is believed to be involved in merozoite attachment and invasion of red blood cells...
  34. ncbi Gene gun-based co-immunization of merozoite surface protein-1 cDNA with IL-12 expression plasmid confers protection against lethal Plasmodium yoelii in A/J mice
    Tohru Sakai
    Department of Parasitology and Immunology, University of Tokushima School of Medicine, Japan
    Vaccine 21:1432-44. 2003
    ..After the Plasmodium yoelii challenge, mice immunized with MSP1-15 plus IL-12 DNA showed a higher level of interferon gamma (IFN-gamma) ..
  35. pmc ATP/ADP binding to a novel nucleotide binding domain of the reticulocyte-binding protein Py235 of Plasmodium yoelii
    Jeya Kumar Ramalingam
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    J Biol Chem 283:36386-96. 2008
    ..Our data suggest that different structural changes induced by ATP/ADP binding to RBL could play an important role during the invasion process...
  36. pmc New active drugs against liver stages of Plasmodium predicted by molecular topology
    Nassira Mahmoudi
    Universite Pierre et Marie Curie Paris 6, UMR S511, Paris F 75013, France
    Antimicrob Agents Chemother 52:1215-20. 2008
    ..relationship (QSAR) study based on a database of 127 compounds previously tested against the liver stage of Plasmodium yoelii in order to develop a model capable of predicting the in vitro antimalarial activities of new compounds...
  37. ncbi Congenicity and genetic polymorphism in cloned lines derived from a single isolate of a rodent malaria parasite
    Sittiporn Pattaradilokrat
    Institute of Immunology and Infection Research, School of Biological Sciences, The University of Edinburgh, Ashworth Laboratories, Edinburgh, UK
    Mol Biochem Parasitol 157:244-7. 2008
    Many of the most commonly studied lines of the rodent malaria parasite Plasmodium yoelii yoelii originated from a single parasite isolate designated 17X...
  38. ncbi Differences in the copy number of the py235 gene family in virulent and avirulent lines of Plasmodium yoelii
    Jayasree K Iyer
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore
    Mol Biochem Parasitol 150:186-91. 2006
    The 235kDa rhoptry protein (Py235) of Plasmodium yoelii is coded for by a multigene family...
  39. ncbi Plasmodium yoelii: differences in the transcription of the 235-kDa rhoptry protein multigene family in lethal and nonlethal lines
    P R Preiser
    Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
    Exp Parasitol 89:50-7. 1998
    ..protein (p235) multigene family in the lethal (YM) and nonlethal (17X) lines of the rodent malaria parasite Plasmodium yoelii. This protein is thought to be involved in erythrocyte invasion by the parasite...
  40. ncbi Development of antimalaria immunity in mice lacking IFN-gamma receptor
    M Tsuji
    Department of Medical and Molecular Parasitology, New York University School of Medicine, NY 10010, USA
    J Immunol 154:5338-44. 1995
    ..IFN-gamma R-/- mice failed to develop protective immunity against Plasmodium yoelii sporozoites or liver stages, upon immunization with a single dose of irradiated sporozoites, whereas in ..
  41. pmc Using green fluorescent malaria parasites to screen for permissive vector mosquitoes
    Friedrich Frischknecht
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 25 28 Rue du Dr Roux, 75015 Paris, France
    Malar J 5:23. 2006
    The Plasmodium species that infect rodents, particularly Plasmodium berghei and Plasmodium yoelii, are useful to investigate host-parasite interactions...
  42. ncbi IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages
    Luzia H Carvalho
    Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York, USA
    Nat Med 8:166-70. 2002
    ..This is the first demonstration that IL-4 is a mediator of CD4/CD8 cross-talk leading to the development of immunity against an infectious pathogen...
  43. pmc A role for immune responses against non-CS components in the cross-species protection induced by immunization with irradiated malaria sporozoites
    Marjorie Mauduit
    Singapore Immunology Network SIgN, Agency for Science, Technology and Research A STAR, Biopolis, Singapore
    PLoS ONE 4:e7717. 2009
    ..This opens the perspective to develop a single vaccine formulation that could protect against multiple parasite species...
  44. pmc Differential effector pathways regulate memory CD8 T cell immunity against Plasmodium berghei versus P. yoelii sporozoites
    Noah S Butler
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 184:2528-38. 2010
    ..Our studies also show that the effector pathways that memory CD8 T cells use to eliminate liver stage infection are, in part, Plasmodium species specific...
  45. pmc Immunogenicity and protection of a recombinant human adenovirus serotype 35-based malaria vaccine against Plasmodium yoelii in mice
    O J A E Ophorst
    Crucell Holland B V, P O Box 2048, 2301 CA Leiden, The Netherlands
    Infect Immun 74:313-20. 2006
    ..5 (rAd5) as a malaria vaccine carrier in preclinical models, we evaluated the potency of rAd35 coding for Plasmodium yoelii circumsporozoite protein (rAd35PyCS)...
  46. ncbi The shiitake mushroom-derived immuno-stimulant lentinan protects against murine malaria blood-stage infection by evoking adaptive immune-responses
    Lian di Zhou
    Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang, China
    Int Immunopharmacol 9:455-62. 2009
    ..We tested the effects of lentinan during blood-stage infection by Plasmodium yoelii 17XL (P.y17XL)...
  47. ncbi A rhoptry-protein-associated mechanism of clonal phenotypic variation in rodent malaria
    P R Preiser
    Division of Parasitology, National Institute for Medical Research, London, UK
    Nature 398:618-22. 1999
    ..This phenomenon is genetically and functionally distinct from classical antigenic variation, which is mediated by the var multigene family of P. falciparum...
  48. pmc Identification and characterization of the Plasmodium yoelii PyP140/RON4 protein, an orthologue of Toxoplasma gondii RON4, whose cysteine-rich domain does not protect against lethal parasite challenge infection
    David L Narum
    Malaria Vaccine Development Branch, NIH, 5640 Fishers Lane, Twinbrook I, Rockville, MD 20852, USA
    Infect Immun 76:4876-82. 2008
    Previously, we identified a Plasmodium yoelii YM 140-kDa merozoite protein, designated PyP140, which formed a complex with apical membrane antigen 1 (AMA1)...
  49. ncbi Expression profiles of peroxiredoxin proteins of the rodent malaria parasite Plasmodium yoelii
    Shin ichiro Kawazu
    Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, 162 8655, Tokyo, Japan
    Int J Parasitol 33:1455-61. 2003
    Patterns of expression of the 2-Cys and 1-Cys peroxiredoxin (Prx) proteins of the rodent malaria parasite Plasmodium yoelii during its life cycle were observed by immunofluorescent antibody staining and confocal laser scanning microscopy...
  50. ncbi Involvement of CD8+ T cells in protective immunity against murine blood-stage infection with Plasmodium yoelii 17XL strain
    Takashi Imai
    Department of Microbiology and Immunology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Immunol 40:1053-61. 2010
    ..found that CD8(+) T cells contribute to protective immunity against infection with blood-stage parasites of Plasmodium yoelii. Infection of C57BL/6 mice with P...
  51. ncbi An unusual tryptophan-rich domain characterizes two secreted antigens of Plasmodium yoelii-infected erythrocytes
    J M Burns
    Department of Microbiology, Meharry Medical College, 1005 D B Todd Blvd, Nashville, TN 37208, USA
    Mol Biochem Parasitol 110:11-21. 2000
    Previously, we reported the characterization of pypAg-1, a novel protective membrane protein of Plasmodium yoelii-infected erythrocytes. Immunization studies indicated that pypAg-1 contained at least two protective epitopes...
  52. ncbi The high molecular mass rhoptry protein, RhopH1, is encoded by members of the clag multigene family in Plasmodium falciparum and Plasmodium yoelii
    O Kaneko
    Department of Molecular Parasitology, Ehime University School of Medicine, Shigenobu-cho, Ehime 791-0295, Japan
    Mol Biochem Parasitol 118:223-31. 2001
    ..Using monoclonal antibody-purified protein complex from both Plasmodium falciparum and Plasmodium yoelii, peptides were obtained by digestion of RhopH1 and their sequence determined either by mass spectrometry or ..
  53. ncbi Noninvasive real-time monitoring of liver-stage development of bioluminescent Plasmodium parasites
    Agnes Mwakingwe
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 200:1470-8. 2009
    ..Plasmodium liver stages are the targets of new chemotherapeutics and vaccines, but there are limited tools available to study this stage in vivo...
  54. ncbi Properties of the Plasmodium falciparum homologue of a protective vaccine candidate of Plasmodium yoelii
    A C Uhlemann
    Department of Parasitology, Institute of Tropical Medicine, , Wilhelmstrasse 27, 72074, , Germany
    Mol Biochem Parasitol 118:41-8. 2001
    ..yoelii antigen that has been used successfully in vaccine studies. Thus, this P. falciparum antigen should be considered an additional candidate for assessment in vaccination against the asexual blood-stages of P. falciparum...
  55. ncbi Effects of CD4(+)CD25(+)Foxp3(+)regulatory T cells on early Plasmodium yoelii 17XL infection in BALB/c mice
    Guang Chen
    Department of Immunology, College of Basic Medical Sciences, China Medical University, Heping District, Shenyang, China
    Parasitology 136:1107-20. 2009
    The outcome of Plasmodium yoelii 17XL-infected BALB/c and DBA/2 mice, ranging from death to spontaneous cure, respectively, depends largely on the establishment of effective pro-inflammatory type 1 responses during the early stages of ..
  56. pmc Minimal role for the circumsporozoite protein in the induction of sterile immunity by vaccination with live rodent malaria sporozoites
    Marjorie Mauduit
    Laboratory of Malaria Immunology, Singapore Immunology Network, Agency for Science, Technology and Research A STAR, Biopolis, Singapore 138648, Singapore
    Infect Immun 78:2182-8. 2010
    ..we have employed transgenic Plasmodium berghei parasites in which the endogenous CSP was replaced by that of Plasmodium yoelii, another rodent malaria species, to assess the role of CSP in the sterile protection induced by the Spz-plus-..
  57. ncbi Concurrent infection with Heligmosomoides polygyrus suppresses anti-Plasmodium yoelii protection partially by induction of CD4(+)CD25(+)Foxp3(+) Treg in mice
    Kohhei Tetsutani
    Department of Parasitology, Kyushu University Graduate School of Medical Science, Fukuoka 812 0054, Japan
    Eur J Immunol 39:2822-30. 2009
    ..Infection of C57BL/6 mice with Plasmodium yoelii 17XNL (Py) was transient and self-limiting, but preceding infection with Heligmosomoides polygyrus (Hp), a ..
  58. pmc Gene encoding erythrocyte binding ligand linked to blood stage multiplication rate phenotype in Plasmodium yoelii yoelii
    Sittiporn Pattaradilokrat
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Proc Natl Acad Sci U S A 106:7161-6. 2009
    ..The rodent malaria parasite Plasmodium yoelii yoelii has strains with marked differences in multiplication rate and pathogenicity in the blood...
  59. ncbi Liver CD4-CD8- NK1.1+ TCR alpha beta intermediate cells increase during experimental malaria infection and are able to exhibit inhibitory activity against the parasite liver stage in vitro
    S Pied
    Institut National de la Santé et de la Recherche Médicale U313, Immunobiologie Cellulaire et Moleculaire des Infections Parasitaires, CHU Pitie Salpetriere, Paris, France
    J Immunol 164:1463-9. 2000
    Experimental infection of C57BL/6 mice by Plasmodium yoelii sporozoites induced an increase of CD4-CD8- NK1.1+ TCR alpha beta int cells and a down-regulation of CD4+ NK1...
  60. pmc CD4(+) T-cell- and gamma interferon-dependent protection against murine malaria by immunization with linear synthetic peptides from a Plasmodium yoelii 17-kilodalton hepatocyte erythrocyte protein
    Y Charoenvit
    Malaria Program, Naval Medical Research Center, Bethesda, Maryland 20814 5055, USA
    Infect Immun 67:5604-14. 1999
    ..We recently reported that immunization of A/J mice with an 18-amino-acid synthetic linear peptide from Plasmodium yoelii sporozoite surface protein 2 (SSP2) in TiterMax adjuvant induces sterile protection that is dependent on CD4(..
  61. ncbi Plasmodium yoelii: effects of red blood cell modification and antibodies on the binding characteristics of the 235-kDa rhoptry protein
    S A Ogun
    Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, United Kingdom
    Exp Parasitol 95:187-95. 2000
    The 235-kDa rhoptry protein of the rodent malaria parasite Plasmodium yoelii yoelii was shown to bind to the surface of mouse red blood cells in a calcium-independent process, using a erythrocyte-binding assay...
  62. ncbi Pyrimethamine induces oxidative stress in Plasmodium yoelii 17XL-infected mice: a novel immunomodulatory mechanism of action for an old antimalarial drug?
    Martha Legorreta-Herrera
    Laboratorio de Inmunología Molecular, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autonoma de Mexico, Mexico, D F, Mexico
    Exp Parasitol 126:381-8. 2010
    ..BALB/c and CBA/Ca mice were infected with Plasmodium yoelii 17XL. Seven days after infection, mice were treated with PYR or vehicle and sacrificed 24h later...
  63. ncbi Protective T cell immunity against malaria liver stage after vaccination with live sporozoites under chloroquine treatment
    Elodie Belnoue
    Department of Immunology, Institut National de la Sante et de la Recherche Medicale, Unité 567, Centre National de la Recherche Scientifique, Universite Rene Descartes, Hopital Cochin, Paris, France
    J Immunol 172:2487-95. 2004
    In this study we present the first systematic analysis of the immunity induced by normal Plasmodium yoelii sporozoites in mice...
  64. ncbi Nitric oxide protects against chloroquine resistant Plasmodium yoelii nigeriensis parasites in vitro
    Aradhana Awasthi
    Immunopharmacology Lab, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India
    Exp Parasitol 105:184-91. 2003
    ..These findings support the proposition that nitric oxide has a crucial role in the control of parasitaemia at the initial periods of blood stage malarial infection...
  65. pmc Induction of protective immunity against malaria by priming-boosting immunization with recombinant cold-adapted influenza and modified vaccinia Ankara viruses expressing a CD8+-T-cell epitope derived from the circumsporozoite protein of Plasmodium yoelii
    Gloria Gonzalez-Aseguinolaza
    Department of Medical and Molecular Parasitology, NYU School of Medicine Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 77:11859-66. 2003
    ..This vaccination regimen elicited high levels of protection against malaria. This is the first time that the vaccine efficacy of a recombinant cold-adapted influenza virus vector expressing a foreign antigen has been evaluated...
  66. ncbi Two serine proteases from Anopheles dirus haemocytes exhibit changes in transcript abundance after infection of an incompatible rodent malaria parasite, Plasmodium yoelii
    Wenyue Xu
    Department of Pathobiology, The Third Military Medical University, Chongqing 400038, PR China
    Vet Parasitol 139:93-101. 2006
    ..dirus infected with Plasmodium yoelii (P...
  67. ncbi Eurycoma longifolia extract-artemisinin combination: parasitemia suppression of Plasmodium yoelii-infected mice
    M A R Mohd Ridzuan
    Herbal Medicine Research Center, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
    Trop Biomed 24:111-8. 2007
    ..This study showed that combination treatment of TA164 with artemisinin gives a promising potential anti malaria candidate using both oral and subcutaneous route, the later being the most potent...
  68. pmc The generation and evaluation of two panels of epitope-matched mouse IgG1, IgG2a, IgG2b and IgG3 antibodies specific for Plasmodium falciparum and Plasmodium yoelii merozoite surface protein 1-19 (MSP1(19))
    Jaime R Adame-Gallegos
    Lab C4, Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Exp Parasitol 130:384-93. 2012
    ..region of Plasmodium falciparum merozoite surface protein 1 (PfMSP1(19)), and to the homologous antigen from Plasmodium yoelii (P. yoelii), both major targets of protective immune responses...
  69. pmc A multigene family that interacts with the amino terminus of plasmodium MSP-1 identified using the yeast two-hybrid system
    Kerrianne Mello
    Division of Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Eukaryot Cell 1:915-25. 2002
    ..that interact with a region of the amino-terminal proteolytic fragment of MSP-1 from the mouse parasite Plasmodium yoelii. This analysis has led to the isolation of two sequence-related molecules, one of which is the P...
  70. ncbi Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells
    Hajime Hisaeda
    Department of Parasitology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    J Immunol 180:2496-503. 2008
    ..Infection of mice with the rodent malaria parasite Plasmodium yoelii activates Tregs, leading to enhancement of their suppressive function...
  71. pmc Polysaccharides from the Chinese medicinal herb Achyranthes bidentata enhance anti-malarial immunity during Plasmodium yoelii 17XL infection in mice
    Xiaotong Zhu
    Department of Immunology, College of Basic Medical Sciences, China Medical University, NO, 92, Bei Er Road, Heping District, Shenyang, Liaoning 110001, China
    Malar J 11:49. 2012
    ..The aim of this study is to use the rodent malaria model Plasmodium yoelii 17XL (P...
  72. ncbi Antagonist effect of chloroquine and tumor necrosis factor on hepatic oxidative stress and antioxidant defense in normal and Plasmodium yoelii nigeriensis-infected mice
    N J Siddiqi
    Department of Biochemistry, College of Science, King Saud University, P O Box 2455, Riyadh 11451, Saudi Arabia
    In Vivo 16:67-70. 2002
    b>Plasmodium yoelii nigeriensis (P. y. nigeriensis) produces lethal malaria infection in Swiss albino mice. Tumor necrosis factor (TNF) has been implicated in the pathogenesis of malaria by production of reactive oxygen species...
  73. pmc Alpha-tocopherol transfer protein disruption confers resistance to malarial infection in mice
    Maria S Herbas
    Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2 13, Inada, Obihiro, 080 8555 Japan
    Malar J 9:101. 2010
    ..However, mechanisms of this Plasmodium inhibition, in addition to means by which to exploit this finding as a therapeutic strategy, remain unclear...
  74. ncbi Merozoite surface protein-1 of Plasmodium yoelii fused via an oligosaccharide moiety of cholera toxin B subunit glycoprotein expressed in yeast induced protective immunity against lethal malaria infection in mice
    Takeshi Miyata
    Molecular Microbiology Group, Department of Tropical Infectious Diseases, COMB, Tropical Biosphere Research Center, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903 0213, Japan
    Vaccine 30:948-58. 2012
    ..scaffold for the C-terminal 19-kDa merozoite surface protein-1 (MSP1-19) of the rodent malaria parasite, Plasmodium yoelii. Conjugation of MSP1-19 to PpCTB via its oligosaccharide moiety induced higher protective efficacy against ..
  75. pmc Immunogenicity and protective efficacy of a Plasmodium yoelii Hsp60 DNA vaccine in BALB/c mice
    G I Sanchez
    Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910-7500, USA
    Infect Immun 69:3897-905. 2001
    The gene encoding the 60-kDa heat shock protein of Plasmodium yoelii (PyHsp60) was cloned into the VR1012 and VR1020 mammalian expression vectors...
  76. pmc Structural characterization of the erythrocyte binding domain of the reticulocyte binding protein homologue family of Plasmodium yoelii
    Ardina Grüber
    School of Biological Sciences, Nanyang Technological University, Singapore 637551
    Infect Immun 79:2880-8. 2011
    ..here, we delineated the erythrocyte binding domain (EBD) of one member of the RH family, termed Py235, from Plasmodium yoelii. Moreover, we have obtained the low-resolution structure of the EBD using small-angle X-ray scattering...
  77. ncbi IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model
    D L Doolan
    Malaria Program, Naval Medical Research Center, Bethesda, MD 20889, USA
    J Immunol 163:884-92. 1999
    ....
  78. ncbi Production, characterisation and immunogenicity of a plant-made Plasmodium antigen--the 19 kDa C-terminal fragment of Plasmodium yoelii merozoite surface protein 1
    Charles Ma
    Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia
    Appl Microbiol Biotechnol 94:151-61. 2012
    ..b>Plasmodium yoelii MSP1(19) (PyMSP1(19)) was produced in Nicotiana benthamiana using the MagnICON® deconstructed TMV-based ..
  79. ncbi Strong impact of CD4+ Foxp3+ regulatory T cells and limited effect of T cell-derived IL-10 on pathogen clearance during Plasmodium yoelii infection
    Simone Abel
    Institute of Medical Microbiology, University Hospital Essen, University Duisburg Essen, 45122 Essen, Germany
    J Immunol 188:5467-77. 2012
    ..In this study, we report that specific ablation of Foxp3(+) Tregs in Plasmodium yoelii-infected DEREG-BALB/c mice leads to an increase in T cell activation accompanied by a significant decrease ..
  80. ncbi Oxidative phosphorylation and rotenone-insensitive malate- and NADH-quinone oxidoreductases in Plasmodium yoelii yoelii mitochondria in situ
    Sergio A Uyemura
    Laboratory of Molecular Parasitology, Department of Pathobiology and Center for Zoonoses Research, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    J Biol Chem 279:385-93. 2004
    Respiration, membrane potential, and oxidative phosphorylation of mitochondria of Plasmodium yoelii yoelii trophozoites were assayed in situ after permeabilization with digitonin...
  81. pmc Evaluation of vaccines designed to induce protective cellular immunity against the Plasmodium yoelii circumsporozoite protein: vaccinia, pseudorabies, and Salmonella transformed with circumsporozoite gene
    M Sedegah
    Infectious Diseases Department, Naval Medical Research Institute, Bethesda, MD 20814 5055
    Bull World Health Organ 68:109-14. 1990
    In an attempt to induce a protective cytotoxic T-cell mediated immunity against sporozoites of Plasmodium yoelii, the gene encoding the P...
  82. pmc Automated estimation of parasitaemia of Plasmodium yoelii-infected mice by digital image analysis of Giemsa-stained thin blood smears
    Charles Ma
    Department of Microbiology, Monash University, Clayton, VIC 3800, Australia
    Malar J 9:348. 2010
    ..Here the development of image-analysis software, named Plasmodium AutoCount, which can automatically generate parasitaemia values from Plasmodium-infected blood smears, is reported...
  83. ncbi Plasmodium yoelii: a differential fluorescent technique using Acridine Orange to identify infected erythrocytes and reticulocytes in Duffy knockout mouse
    Lili Xu
    Laboratory of Cell Biology, New York Blood Center, New York 10021, USA
    Exp Parasitol 110:80-7. 2005
    Both human malarial parasite Plasmodium vivax and mouse malaria parasite Plasmodium yoelii use Duffy protein as the receptor for invasion and they preferentially invade reticulocytes. Recently, it has been shown that P...
  84. pmc Type II fatty acid synthesis is essential only for malaria parasite late liver stage development
    Ashley M Vaughan
    Seattle Biomedical Research Institute, Seattle, WA 98109, USA
    Cell Microbiol 11:506-20. 2009
    ..This was confirmed by knockout of FabZ, another critical FAS II enzyme. However, FAS II-deficient Plasmodium yoelii liver stages failed to form exo-erythrocytic merozoites, the invasive stage that first initiates blood stage ..
  85. ncbi Involvement of prophenoloxidases in the suppression of Plasmodium yoelii development by Anopheles dirus
    Ying Wang
    Department of Pathogenic Biology, College of Basic Medical Sciences, Third Military Medical University, Shapingba District, Chongqing 400038, PR China
    Exp Parasitol 123:6-10. 2009
    Anopheles dirus is refractory to a rodent malaria parasite, Plasmodium yoelii, and melanized oocysts are manifested in infected mosquitoes...
  86. ncbi Gene structure and ookinete expression of the chitinase genes of Plasmodium vivax and Plasmodium yoelii
    Takafumi Tsuboi
    Department of Molecular Parasitology, Ehime University School of Medicine, Shigenobu cho, Ehime 791 0295, Japan
    Mol Biochem Parasitol 130:51-4. 2003
  87. ncbi Characterization of immune responses to single or mixed infections with P. yoelii 17XL and P. chabaudi AS in different strains of mice
    Guang Chen
    Department of Immunology, College of Basic Medical Sciences, China Medical University, Heping District, Shenyang, China
    Parasitol Int 59:400-6. 2010
    The outcome of Plasmodium yoelii 17XL (P...
  88. ncbi The domain on the mouse Duffy protein for Plasmodium yoelii binding and invasion to mouse erythrocytes
    Lili Xu
    Laboratory of Cell Biology, New York Blood Center, NY 10021, USA
    Mol Biochem Parasitol 146:142-50. 2006
    ..vivax ligand binding and invasion to red blood cells. Plasmodium yoelii is frequently used to study the interaction between host receptors and parasite ligands...
  89. ncbi Oral delivery of curcumin bound to chitosan nanoparticles cured Plasmodium yoelii infected mice
    Feroz Akhtar
    School of Biotechnology, Jawaharlal Nehru University, New Delhi, India
    Biotechnol Adv 30:310-20. 2012
    ..While mice infected with a lethal strain of Plasmodium yoelii (N-67) died between 8 and 9 days post infection, feeding of chitosan nanoparticles alone made them to ..
  90. pmc Plasmodium yoelii macrophage migration inhibitory factor is necessary for efficient liver-stage development
    Jessica L Miller
    Seattle Biomedical Research Institute, Seattle, Washington, USA
    Infect Immun 80:1399-407. 2012
    ..In this study, we characterized the MIF homologue of Plasmodium yoelii throughout the life cycle, with emphasis on preerythrocytic stages. P...
  91. pmc Remarkable stability in patterns of blood-stage gene expression during episodes of non-lethal Plasmodium yoelii malaria
    Amy Cernetich-Ott
    Centre for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Malar J 11:265. 2012
    ..The aim of this study was to examine changes in gene expression of the rodent malaria parasite, Plasmodium yoelii 17X, while varying the in vivo setting of replication.
  92. pmc Incomplete depletion and rapid regeneration of Foxp3+ regulatory T cells following anti-CD25 treatment in malaria-infected mice
    Kevin N Couper
    Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, U K
    J Immunol 178:4136-46. 2007
    ....
  93. ncbi Structural and functional comparison of MIF ortholog from Plasmodium yoelii with MIF from its rodent host
    Dingding Shao
    Department of Microbiology and Parasitology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, 5 Dong Dan 3 Tiao, Beijing 100005, China
    Mol Immunol 47:726-37. 2010
    ..These data suggest that PyMIF modulates host immune responses together with host MIF and has potential to prolong parasitemia or the chronicity of malaria infection...
  94. ncbi CTLA-4 blockade differentially influences the outcome of non-lethal and lethal Plasmodium yoelii infections
    Bernd Lepenies
    Department of Immunology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20359 Hamburg, Germany
    Microbes Infect 9:687-94. 2007
    ..In contrast, blockade of CTLA-4 during infection with a P. yoelii strain exhibiting a higher parasitemia induced markedly increased serum-levels of TNF-alpha, which was associated with severe inflammation and reduced survival...
  95. pmc Long-lasting protective immune response to the 19-kilodalton carboxy-terminal fragment of Plasmodium yoelii merozoite surface protein 1 in mice
    Pimmada Jeamwattanalert
    Department of Microbiology, Mahidol University, Bangkok, Thailand
    Clin Vaccine Immunol 14:342-7. 2007
    ..As such, we immunized BALB/c mice with a standard four-dose injection of recombinant Plasmodium yoelii MSP1(19) formulated with Montanide ISA51 and CpG oligodeoxynucleotide (ODN) and monitored the MSP1(19)-..
  96. ncbi Mycobacterium bovis bacillus calmette-guérin induces protective immunity against infection by Plasmodium yoelii at blood-stage depending on shifting immunity toward Th1 type and inducing protective IgG2a after the parasite infection
    S Matsumoto
    School of Dentistry, Nagasaki University, Sakamoto 1 7 1, 852 8588, Nagasaki, Japan
    Vaccine 19:779-87. 2000
    ..calmette-guérin (BCG)-vaccination raised dramatically the survival rates of A/J mice from infection by Plasmodium yoelii 17XL at blood-stage...
  97. ncbi FRET peptides reveal differential proteolytic activation in intraerythrocytic stages of the malaria parasites Plasmodium berghei and Plasmodium yoelii
    Laura Nogueira da Cruz
    Department of Parasitology, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Av Prof Lineu Prestes, 1374 Edifício Biomédicas II, CEP 05508 900, Sao Paulo, SP, Brazil
    Int J Parasitol 41:363-72. 2011
    ..In Plasmodium berghei both EGTA and BAPTA blocked protease activation, whilst in Plasmodium yoelii these compounds caused protease activation...
  98. pmc Effect of Plasmodium yoelii exposure on vaccination with the 19-kilodalton carboxyl terminus of merozoite surface protein 1 and vice versa and implications for the application of a human malaria vaccine
    Jiraprapa Wipasa
    Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Infect Immun 77:817-24. 2009
    ..the antibody response that develops following exposure to the malaria vaccine candidate homologue Plasmodium yoelii MSP1(19) in mice that had previously experienced malaria infection and vice versa...
  99. pmc Analysis of immunological nonresponsiveness to the 19-kilodalton fragment of merozoite surface Protein 1 of Plasmodium yoelii: rescue by chemical conjugation to diphtheria toxoid (DT) and enhancement of immunogenicity by prior DT vaccination
    Danielle I Stanisic
    The Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane 4029, Australia
    Infect Immun 71:5700-13. 2003
    ..We show that immunization with the recombinant Plasmodium yoelii 19-kDa fragment of MSP1 (MSP1(19)) expressed in Saccharomyces cerevisiae (yMSP1(19)) can induce protective ..
  100. ncbi Inhibition of Plasmodium yoelii blood-stage malaria by interferon alpha through the inhibition of the production of its target cell, the reticulocyte
    A M Vigario
    INSERM Unité 445, ICGM, Universite Rene Descartes, Hopital Cochin, bâtiment Gustave Roussy, 27, rue du Fbg Saint Jacques, 75014 Paris, France
    Blood 97:3966-71. 2001
    ..human interferon alpha (IFN-alpha) (which cross-reacts with murine cells) on C57BL/6 mice infected with Plasmodium yoelii sporozoites or parasitized erythrocytes was determined...
  101. ncbi Blood schizontocidal activity of selected 1,2,4-trioxanes (Fenozans) against the multidrug-resistant strain of Plasmodium yoelii nigeriensis (MDR) in vivo
    R Tripathi
    Division of Parasitology, Central Drug Research Institute, Lucknow, India
    Parasitology 133:1-9. 2006
    ..45, 48 and 51) have been re-investigated to establish their curative doses against the multidrug-resistant Plasmodium yoelii nigeriensis strain, which is lethal in Swiss mice...

Research Grants40

  1. Purine Pathways and Inhibitor Design in Plasmodium
    Vern L Schramm; Fiscal Year: 2012
    ..their respective pathways and kill parasites cultured in human erythrocytes, but do not cure infections of Plasmodium yoelii in mice, an animal model of the disease...
  2. VACCINE INDUCED IMMUNE RESPONSES TO PLASMODIAL ANTIGENS
    JAMES MATTHEW BURNS; Fiscal Year: 2012
    ..Working in the Plasmodium yoelii rodent model, we have shown that merozoite surface protein-8 is a target of neutralizing antibodies and can ..
  3. Optimizing adenoviral vector to elicit a potent anti-malaria immunity
    Moriya Tsuji; Fiscal Year: 2012
    ..have shown that a recombinant Ad expressing a major malaria antigen, circumsporozoite (CS) antigen of Plasmodium yoelii, AdPyCS, could induce a protective anti-malarial immunity, which is mediated by CD8+ T cells...
  4. High Throughput Genomics Screening for Malaria Antigen Discovery
    Joseph T Bruder; Fiscal Year: 2010
    ..level (>90%) protection against challenge with infectious sporozoites of both the murine malaria parasite Plasmodium yoelii (Py) and the human malaria parasite Pf...
  5. T cell Inhibitory receptor blockade in chronic blood-stage malaria
    John T Harty; Fiscal Year: 2013
    ..surrogate activation marker approach to track the total CD4 and CD8 T cell response in a mouse model of Plasmodium yoelii (Py) chronic blood-stage infection...
  6. Refining the annotations of malaria genomes
    PETER LINN BLAIR; Fiscal Year: 2010
    ..genomes of Plasmodium falciparum, the most debilitating of malaria in humans, and the rodent malaria, Plasmodium yoelii. Given the vast wealth of information provided by such large-scale sequencing projects, including numerous ..
  7. Role of CD4 T cell inhibitor receptors during Plasmodium blood stage infection
    NOAH SULLIVAN BUTLER; Fiscal Year: 2013
    ..Using this approach, the candidate has determined that Plasmodium yoelii blood stage infection results in sustained expression of multiple inhibitory receptors on responding T cells ..
  8. A protective role for IL-17 in blood-stage malaria
    Jason S Stumhofer; Fiscal Year: 2013
    ..Our preliminary studies using IL-17RA-deficient mice indicate that these mice are susceptible to Plasmodium yoelii 17X infection, characterized by a rapid increase in parasite burden, earlier onset of anemia, deficiency in ..
  9. Creation of a tissue culture model for Toxoplasma gondii sexual development
    Laura J Knoll; Fiscal Year: 2010
    ..Recombinant T. gondii expressing circumsporozoite protein from Plasmodium yoelii or P...
  10. Development of a Malaria DNA Vaccine with Enchanced Immunogenicity
    Richard Markham; Fiscal Year: 2009
    ..Based on substantial evidence derived from tumor model systems and preliminary studies with a candidate Plasmodium yoelii vaccine, this proposal hypothesizes that an effective DNA-based vaccine against malaria can be developed by ..
  11. ORGANELLE GENOMES OF MALARIAL PARASITES
    Akhil Vaidya; Fiscal Year: 1991
    ..The entire 6 kb repeating unit from a rodent parasite, Plasmodium yoelii, has been sequenced in our laboratory...
  12. Antigens and Immune Response in Malaria Infection
    RANDY WILSON; Fiscal Year: 2004
    ..murine model of malaria infection to investigate the early and late stages of the immune response to Plasmodium yoelii, with a focus on parasite antigens and their interactions with antigen presenting cells...
  13. DEVELOPMENT OF RECOMBINANT BCG VACCINES FOR MALARIA
    CAROL BERKOWER; Fiscal Year: 2001
    ..will involve the generation of rBCG strains expressing three pre-erythrocytic antigens from mouse malaria, Plasmodium yoelii. Expression of these antigens will be optimized using combinations of promoters and signal sequences...
  14. VACCINE INDUCED IMMUNE RESPONSES TO PLASMODIAL ANTIGENS
    James Burns; Fiscal Year: 1999
    ..We have taken a strict immunization-based approach to this problem. Using the Plasmodium yoelii model to test several crude blood stage antigen and adjuvant combinations, we have established a system of ..
  15. RODENT MALARIAL ANTIGEN--PY117
    Diane Taylor; Fiscal Year: 1991
    ..We recently described a heat-stable antigen (Py117) that circulates in the sera of mice during Plasmodium yoelii infection and an immunologically-related, crossreactive protein (Pf93) that circulates in the sera of humans ..
  16. NKT cells: Novel Protective T cells against malaria
    Moriya Tsuji; Fiscal Year: 2001
    ..These preliminary data further indicate that the insoluble fraction of extracts from Plasmodium yoelii blood stages activates liver lymphoid cells of wild type, but not of NKT-deficient, CD id-mutant mice...
  17. BIOLOGY AND IMMUNOLOGY OF MALARIA PARASITE LIVER-STAGES
    Abdu Azad; Fiscal Year: 2005
    ..To facilitate the analysis of EE-stage parasites, we will identify Plasmodium yoelii gene in the infected mouse liver, the expression of which is induced early after infection, and shut off ..
  18. IMMUNOREGULATION IN MURINE MALARIA
    DONALD WASSOM; Fiscal Year: 1991
    Strains of mice which quickly resolve infections with a nonlethal isolate of Plasmodium yoelii are exquisitely susceptible to infection with a lethal isolate of this same parasite species...
  19. Development of a chimeric mouse model for the analysis of Plasmodium liver stages
    John Sacci; Fiscal Year: 2007
    ..This will then produce a truly comprehensive picture of gene expression during the lifecycle of human malaria parasites. [unreadable] [unreadable]..
  20. Lyophilization of Plasmodium falciparum sporozoite vaccine
    Stephen Hoffman; Fiscal Year: 2007
    ..Additionally, a dried vaccine may accelerate a concerted world-wide effort to eradicate this devastating disease. [unreadable] [unreadable] [unreadable]..
  21. New Topical Therapies for Psoriasis
    Mitchell Avery; Fiscal Year: 2007
    ..The goal of this project is to develop a safe and effective new drug for topical treatment of psoriasis. [unreadable] [unreadable] [unreadable]..
  22. Genetically Attenuated Malaria Sporozote Vaccine
    Stephen Hoffman; Fiscal Year: 2008
    ..Success in this project has the potential to lead to development of a safe, effective, attenuated malaria vaccine. [unreadable] [unreadable] [unreadable]..
  23. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  24. IMMUNOTHERAPY PROTECTION & VACCINES FOR HEPATITIS C
    Charles Rice; Fiscal Year: 2003
    ..It is believed that much of the information gained in these studies will be applicable to vaccine development for man. ..
  25. Viruses And Cells Gordon Conference
    Charles Rice; Fiscal Year: 2005
    ..Funding is requested to support the conference fees for graduate students and postdoctoral fellows to this meeting. ..
  26. Potency of cryopreserved, irradiated sporozoite vaccine
    Stephen Hoffman; Fiscal Year: 2005
    ..The project will also provide a method for cryopreserving unirradiated sporozoites that could be used to challenge volunteers by injection with P. falciparum in vaccine studies worldwide. ..
  27. MOLECULAR GENETICS OF SINDBIS VIRUS REPLICATION
    Charles Rice; Fiscal Year: 2005
    ....
  28. Conference--Drug development for Viral Hepatitis
    Charles Rice; Fiscal Year: 2005
    ..Support is requested to help defray the publications costs of the abstract book and for equipment used to facilitate delivery and display of the oral and poster presentations...
  29. Small Molecules as Research Tools for HCV Biology
    Charles Rice; Fiscal Year: 2004
    ..These studies will provide useful chemical probes for dissecting different steps in the HCV replication cycle with the hope of identifying novel targets for drug development. ..
  30. Development of a cell-based method for high-throughput drug screening in malaria
    Liwang Cui; Fiscal Year: 2008
    ..To facilitate antimalarial drug discovery, we propose to develop a highly sensitive, cell-based, one-step luminescent drug screen assay for high throughput screening of large chemical libraries. [unreadable] [unreadable] [unreadable]..
  31. ROLE OF DUFFY GLYCOPROTEIN IN MURINE MALARIA INFECTIONS
    Christine Olver; Fiscal Year: 2002
    ..molecular biology, test the hypothesis that the murine Duffy glycoprotein is a receptor for the invasion of Plasmodium yoelii into RBC...
  32. Dev & Testing of New Medications for Treatment of Emerging Infectious Diseases
    Mitchell Avery; Fiscal Year: 2006
    ..This allows LADDS infrastructure to inch forward now to the last stages of drug development that are achievable with academic economics. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  33. MOLECULAR DISSECTION OF P. FALCIPARUM SEXUAL DEVELOPMENT
    Nirbhay Kumar; Fiscal Year: 2004
    ..falciparum. Such information could lead to rational development of immunological and/or chemotherapeutic arsenal to prevent transmission of P. falciparum malaria. ..
  34. Immune Pathways as Prerequisites for Adjuvants' Efficacy
    George Hui; Fiscal Year: 2004
    ....
  35. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  36. Falciparum malaria invasion ligand DNA/protein vaccine
    David Narum; Fiscal Year: 2002
    ..S. military has lost more person days to malaria than to bullets (Beadle and Hoffman, 1993). A vaccine against malaria would have enormous domestic and international commercial value. ..
  37. DEVELOPMENT OF NOVEL ANTIFUNGAL ANTIPC NATURAL PRODUCTS
    Mitchell Avery; Fiscal Year: 2001
    ....
  38. Analysis of the Plasmodium merozoite rhoptry proteome
    TOBILI SAM YELLOWE; Fiscal Year: 2006
    ..2) We will analyze rhoptries during schizont development by MudPIT analysis and evaluate the distribution of rhoptry proteins during rhoptry biogenesis. [unreadable] [unreadable]..
  39. Molecular and Functional Genomics of Plasmodium
    Lawrence Bergman; Fiscal Year: 2004
    ..As a part of the Malaria Genome Project, 5X coverage of a rodent malaria parasite Plasmodium yoelii genome has been accomplished by the Institute for Genomic Research (TIGR), and a large collection of cDNA ..
  40. PROTEIN-PROTEIN INTERACTIONS OF PLASMODIAL MSP-1
    Lawrence Bergman; Fiscal Year: 2004
    ..abstract_text> ..