plasmodium falciparum

Summary

Summary: A species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics.

Top Publications

  1. pmc Origin of the human malaria parasite Plasmodium falciparum in gorillas
    Weimin Liu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nature 467:420-5. 2010
  2. pmc Artemisinin resistance in Plasmodium falciparum malaria
    Arjen M Dondorp
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    N Engl J Med 361:455-67. 2009
  3. pmc A new world malaria map: Plasmodium falciparum endemicity in 2010
    Peter W Gething
    Spatial Ecology and Epidemiology Group, Tinbergen Building, Department of Zoology, University of Oxford, South Parks Road, Oxford, UK
    Malar J 10:378. 2011
  4. pmc Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study
    Aung Pyae Phyo
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet 379:1960-6. 2012
  5. pmc A world malaria map: Plasmodium falciparum endemicity in 2007
    Simon I Hay
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine, Kenya Medical Research Institute University of Oxford Wellcome TrustCollaborative Programme, Nairobi, Kenya
    PLoS Med 6:e1000048. 2009
  6. ncbi First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children
    Selidji Todagbe Agnandji
    Albert Schweitzer Hospital, Lambarene, Gabon
    N Engl J Med 365:1863-75. 2011
  7. pmc Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination
    Teun Bousema
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Clin Microbiol Rev 24:377-410. 2011
  8. ncbi Artemisinin resistance: current status and scenarios for containment
    Arjen M Dondorp
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok10400, Thailand
    Nat Rev Microbiol 8:272-80. 2010
  9. pmc The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites' boundaries
    Moritz Treeck
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Host Microbe 10:410-9. 2011
  10. pmc A field trial to assess a blood-stage malaria vaccine
    Mahamadou A Thera
    Malaria Research and Training Center, University of Bamako, Bamako, Mali
    N Engl J Med 365:1004-13. 2011

Detail Information

Publications353 found, 100 shown here

  1. pmc Origin of the human malaria parasite Plasmodium falciparum in gorillas
    Weimin Liu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nature 467:420-5. 2010
    b>Plasmodium falciparum is the most prevalent and lethal of the malaria parasites infecting humans, yet the origin and evolutionary history of this important pathogen remain controversial...
  2. pmc Artemisinin resistance in Plasmodium falciparum malaria
    Arjen M Dondorp
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    N Engl J Med 361:455-67. 2009
    ..There are recent concerns that the efficacy of such therapies has declined on the Thai-Cambodian border, historically a site of emerging antimalarial-drug resistance...
  3. pmc A new world malaria map: Plasmodium falciparum endemicity in 2010
    Peter W Gething
    Spatial Ecology and Epidemiology Group, Tinbergen Building, Department of Zoology, University of Oxford, South Parks Road, Oxford, UK
    Malar J 10:378. 2011
    ..Following the first global effort to map Plasmodium falciparum malaria endemicity in 2007, this paper describes the generation of a new world map for the year 2010...
  4. pmc Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study
    Aung Pyae Phyo
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet 379:1960-6. 2012
    ..A concerted international effort is underway to contain artemisinin-resistant Plasmodium falciparum, but containment strategies are dependent on whether resistance has emerged elsewhere...
  5. pmc A world malaria map: Plasmodium falciparum endemicity in 2007
    Simon I Hay
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine, Kenya Medical Research Institute University of Oxford Wellcome TrustCollaborative Programme, Nairobi, Kenya
    PLoS Med 6:e1000048. 2009
    ..It is exactly 40 y since the last global map of malaria endemicity was published. This paper describes the generation of a new world map of Plasmodium falciparum malaria endemicity for the year 2007.
  6. ncbi First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children
    Selidji Todagbe Agnandji
    Albert Schweitzer Hospital, Lambarene, Gabon
    N Engl J Med 365:1863-75. 2011
    ..An ongoing phase 3 study of the efficacy, safety, and immunogenicity of candidate malaria vaccine RTS,S/AS01 is being conducted in seven African countries...
  7. pmc Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination
    Teun Bousema
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Clin Microbiol Rev 24:377-410. 2011
    Malaria remains a major cause of morbidity and mortality in the tropics, with Plasmodium falciparum responsible for the majority of the disease burden and P. vivax being the geographically most widely distributed cause of malaria...
  8. ncbi Artemisinin resistance: current status and scenarios for containment
    Arjen M Dondorp
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok10400, Thailand
    Nat Rev Microbiol 8:272-80. 2010
    Artemisinin combination therapies are the first-line treatments for uncomplicated Plasmodium falciparum malaria in most malaria-endemic countries. Recently, partial artemisinin-resistant P...
  9. pmc The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites' boundaries
    Moritz Treeck
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Host Microbe 10:410-9. 2011
    b>Plasmodium falciparum and Toxoplasma gondii are obligate intracellular apicomplexan parasites that rapidly invade and extensively modify host cells...
  10. pmc A field trial to assess a blood-stage malaria vaccine
    Mahamadou A Thera
    Malaria Research and Training Center, University of Bamako, Bamako, Mali
    N Engl J Med 365:1004-13. 2011
    ..1/AS02(A), a recombinant protein based on apical membrane antigen 1 (AMA1) from the 3D7 strain of Plasmodium falciparum, has previously been shown to have immunogenicity and acceptable safety in Malian adults and children.
  11. ncbi A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants
    Selidji Todagbe Agnandji
    Albert Schweitzer Hospital, Lambarene, Gabon
    N Engl J Med 367:2284-95. 2012
    ..We studied infants 6 to 12 weeks of age recruited for the same trial...
  12. pmc A major genome region underlying artemisinin resistance in malaria
    Ian H Cheeseman
    Texas Biomedical Research Institute, San Antonio, TX 78245, USA
    Science 336:79-82. 2012
    ....
  13. pmc Quantifying the number of pregnancies at risk of malaria in 2007: a demographic study
    Stephanie Dellicour
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
    PLoS Med 7:e1000221. 2010
    ..We derived global estimates of the number of women who became pregnant in 2007 in areas with Plasmodium falciparum and P. vivax transmission.
  14. pmc Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum
    Cecile Crosnier
    Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Nature 480:534-7. 2011
    Erythrocyte invasion by Plasmodium falciparum is central to the pathogenesis of malaria...
  15. pmc Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator
    Jennifer A Flegg
    WorldWide Anti malarial Resistance Network WWARN and Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford, OX3 7LJ, UK
    Malar J 10:339. 2011
    ..measurement of parasite clearance is therefore essential to assess the spread of artemisinin resistance in Plasmodium falciparum. The slope of the log-parasitaemia versus time relationship is considered to be the most robust measure of ..
  16. ncbi Thousands of chemical starting points for antimalarial lead identification
    Francisco Javier Gamo
    Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Spain
    Nature 465:305-10. 2010
    ..Chemical structures and associated data are hereby made public to encourage additional drug lead identification efforts and further research into this disease...
  17. pmc Natural microbe-mediated refractoriness to Plasmodium infection in Anopheles gambiae
    Chris M Cirimotich
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205 2179, USA
    Science 332:855-8. 2011
    ..populations in Zambia that renders the mosquito resistant to infection with the human malaria parasite Plasmodium falciparum by interfering with parasite development before invasion of the midgut epithelium...
  18. pmc The relationship between anti-merozoite antibodies and incidence of Plasmodium falciparum malaria: A systematic review and meta-analysis
    Freya J I Fowkes
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    PLoS Med 7:e1000218. 2010
    ..However, published evidence of the protective effect of these antibodies is conflicting...
  19. pmc Climate change and the global malaria recession
    Peter W Gething
    Spatial Ecology and Epidemiology Group, Tinbergen Building, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Nature 465:342-5. 2010
    ..The contemporary spatial limits of Plasmodium falciparum malaria and its endemicity within this range, when compared with comparable historical maps, offer unique ..
  20. pmc Changing patterns of malaria epidemiology between 2002 and 2010 in Western Kenya: the fall and rise of malaria
    Guofa Zhou
    Program in Public Health, College of Health Sciences, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 6:e20318. 2011
    ..To evaluate the impacts of ITNs on malaria transmission, we conducted monthly surveys in three sentinel sites with different transmission intensities in western Kenya from 2002 to 2010...
  21. ncbi The state of the art in anti-malarial drug discovery and development
    Jeremy N Burrows
    Medicines for Malaria Venture, ICC, Geneva, Switzerland
    Curr Top Med Chem 11:1226-54. 2011
    ..apart from artemisinin combination therapies there are relatively few effective treatments for Plasmodium falciparum and only one treatment for the radical cure of Plasmodium vivax...
  22. ncbi Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum
    T J Anderson
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, England
    Mol Biol Evol 17:1467-82. 2000
    ..The population structure of the protozoan parasite Plasmodium falciparum has been harder to evaluate, since most studies have used a limited number of antigen-encoding loci that ..
  23. pmc How malaria has affected the human genome and what human genetics can teach us about malaria
    Dominic P Kwiatkowski
    Wellcome Trust Centre for Human Genetics and University Department of Paediatrics, Oxford, United Kingdom
    Am J Hum Genet 77:171-92. 2005
    ....
  24. pmc Artemisinin combination therapy for vivax malaria
    Nicholas M Douglas
    Menzies School of Health Research, Darwin, NT, Australia
    Lancet Infect Dis 10:405-16. 2010
    ..disadvantages of the existing separate treatment approach versus a unified ACT-based strategy for treating Plasmodium falciparum and P vivax infections in regions where both species are endemic (co-endemic)...
  25. pmc A peroxidase/dual oxidase system modulates midgut epithelial immunity in Anopheles gambiae
    Sanjeev Kumar
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Science 327:1644-8. 2010
    ..Disruption of this barrier results in strong and effective pathogen-specific immune responses...
  26. pmc A large proportion of asymptomatic Plasmodium infections with low and sub-microscopic parasite densities in the low transmission setting of Temotu Province, Solomon Islands: challenges for malaria diagnostics in an elimination setting
    Ivor Harris
    Australian Army Malaria Institute, Weary Dunlop Drive, Gallipoli Barracks Enoggera, QLD 4051, Australia
    Malar J 9:254. 2010
    ....
  27. pmc Genome sequence of the human malaria parasite Plasmodium falciparum
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:498-511. 2002
    The parasite Plasmodium falciparum is responsible for hundreds of millions of cases of malaria, and kills more than one million African children annually. Here we report an analysis of the genome sequence of P. falciparum clone 3D7...
  28. ncbi Malaria in pregnancy: pathogenesis and immunity
    Stephen J Rogerson
    Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Lancet Infect Dis 7:105-17. 2007
    ..to malaria in pregnancy was recently advanced by the discovery that erythrocytes infected with Plasmodium falciparum accumulate in the placenta through adhesion to molecules such as chondroitin sulphate A...
  29. pmc Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, Indonesia
    Emiliana Tjitra
    National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia
    PLoS Med 5:e128. 2008
    ..The aim of the study was to review the spectrum of disease associated with malaria due to Pv and P. falciparum (Pf) in patients presenting to a hospital in Timika, southern Papua, Indonesia...
  30. pmc Reduction in the proportion of fevers associated with Plasmodium falciparum parasitaemia in Africa: a systematic review
    Valérie D'Acremont
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Malar J 9:240. 2010
    ..The objective of this systematic review was to estimate the change in the Proportion of Fevers associated with Plasmodium falciparum parasitaemia (PFPf) over the past 20 years in sub-Saharan Africa.
  31. pmc Implication of the mosquito midgut microbiota in the defense against malaria parasites
    Yuemei Dong
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Pathog 5:e1000423. 2009
    ..molecular interplay between the bacterial co-infection and the development of the human malaria parasite Plasmodium falciparum in its natural vector Anopheles gambiae...
  32. pmc Chemical genetics of Plasmodium falciparum
    W Armand Guiguemde
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 465:311-5. 2010
    Malaria caused by Plasmodium falciparum is a disease that is responsible for 880,000 deaths per year worldwide. Vaccine development has proved difficult and resistance has emerged for most antimalarial drugs...
  33. pmc Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum
    Connor O'Brien
    Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Curr Opin Infect Dis 24:570-7. 2011
    ..However, recent reports from the Thai-Cambodian border reveal evidence of emerging resistance to artemisinins. The latest published clinical and molecular findings are summarized herein...
  34. pmc Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing
    Magnus Manske
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Nature 487:375-9. 2012
    ..Here we describe methods for the large-scale analysis of genetic variation in Plasmodium falciparum by deep sequencing of parasite DNA obtained from the blood of patients with malaria, either directly or ..
  35. ncbi Live attenuated malaria vaccine designed to protect through hepatic CD8⁺ T cell immunity
    J E Epstein
    U S Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    Science 334:475-80. 2011
    Our goal is to develop a vaccine that sustainably prevents Plasmodium falciparum (Pf) malaria in ≥80% of recipients...
  36. ncbi Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte
    David T Riglar
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia
    Cell Host Microbe 9:9-20. 2011
    ..the poor invasion synchrony of merozoites from the only in vitro culture-adapted human malaria parasite, Plasmodium falciparum. Using fluorescence, three-dimensional structured illumination, and immunoelectron microscopy of filtered ..
  37. pmc Wolbachia infections are virulent and inhibit the human malaria parasite Plasmodium falciparum in Anopheles gambiae
    Grant L Hughes
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Pathog 7:e1002043. 2011
    ..Both wMelPop and wAlbB significantly inhibit Plasmodium falciparum oocyst levels in the mosquito midgut...
  38. ncbi The pathogenic basis of malaria
    Louis H Miller
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 415:673-9. 2002
    ..The inability of many countries to fund expensive campaigns and antimalarial treatment requires these tools to be highly effective and affordable...
  39. pmc Vaccines against malaria
    Adrian V S Hill
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX37DQ, UK
    Philos Trans R Soc Lond B Biol Sci 366:2806-14. 2011
    There is no licenced vaccine against any human parasitic disease and Plasmodium falciparum malaria, a major cause of infectious mortality, presents a great challenge to vaccine developers...
  40. pmc Engineered anopheles immunity to Plasmodium infection
    Yuemei Dong
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Pathog 7:e1002458. 2011
    A causative agent of human malaria, Plasmodium falciparum, is transmitted by Anopheles mosquitoes. The malaria parasite is under intensive attack from the mosquito's innate immune system during its sporogonic development...
  41. pmc False-negative rapid diagnostic tests for malaria and deletion of the histidine-rich repeat region of the hrp2 gene
    Ousmane A Koita
    Mali Tulane Tropical Medicine Research Center, Faculty of Medicine, Pharmacy, and Dentistry, University of Bamako, Bamako, Mali
    Am J Trop Med Hyg 86:194-8. 2012
    We identified 480 persons with positive thick smears for asexual Plasmodium falciparum parasites, of whom 454 had positive rapid diagnostic tests (RDTs) for the histidine-rich protein 2 (HRP2) product of the hrp2 gene and 26 had negative ..
  42. ncbi Identification of hot spots of malaria transmission for targeted malaria control
    Teun Bousema
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom
    J Infect Dis 201:1764-74. 2010
    ..This heterogeneity creates opportunities for targeted interventions but only if hot spots of malaria transmission can be easily identified...
  43. ncbi Artemisinin resistance in Cambodia: a clinical trial designed to address an emerging problem in Southeast Asia
    Harald Noedl
    Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria
    Clin Infect Dis 51:e82-9. 2010
    ..This article provides additional data from a clinical trial that has been published in The New England Journal of Medicine...
  44. pmc The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody
    Alexander D Douglas
    Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
    Nat Commun 2:601. 2011
    Current vaccine strategies against the asexual blood stage of Plasmodium falciparum are mostly focused on well-studied merozoite antigens that induce immune responses after natural exposure, but have yet to induce robust protection in ..
  45. pmc A cryptic subgroup of Anopheles gambiae is highly susceptible to human malaria parasites
    Michelle M Riehle
    Institut Pasteur, Unit of Insect Vector Genetics and Genomics, Department of Parasitology and Mycology, 28 rue du Docteur Roux, Paris 75015, France
    Science 331:596-8. 2011
    ..is abundant, lacks differentiation into M and S molecular forms, and is highly susceptible to infection with wild Plasmodium falciparum. These findings might have implications for the epidemiology of malaria transmission and control.
  46. pmc Investigating the host binding signature on the Plasmodium falciparum PfEMP1 protein family
    Joel H Janes
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 7:e1002032. 2011
    The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family plays a central role in antigenic variation and cytoadhesion of P. falciparum infected erythrocytes...
  47. pmc Malaria in Brazil: an overview
    Joseli Oliveira-Ferreira
    Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz, FIOCRUZ, Pavilhão Leônidas Deane 5 degrees andar, Av Brasil 4365, Manguinhos, Rio de Janeiro, RJ CEP 21 045 900, RJ Brazil
    Malar J 9:115. 2010
    ..Plasmodium vivax accounts for 83,7% of registered cases, while Plasmodium falciparum is responsible for 16,3% and Plasmodium malariae is seldom observed...
  48. pmc African apes as reservoirs of Plasmodium falciparum and the origin and diversification of the Laverania subgenus
    Linda Duval
    Laboratoire de Biologie fonctionnelle des protozoaires, Unité Scientifique du Muséum 504, Museum national d histoire naturelle, 75005 Paris, France
    Proc Natl Acad Sci U S A 107:10561-6. 2010
    ..One gorilla sample is related to Plasmodium falciparum, thus confirming the recently reported presence in gorillas of this parasite...
  49. pmc Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites
    Dave Richard
    Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria 3052, Australia
    J Biol Chem 285:14815-22. 2010
    Invasion of host cells by apicomplexan parasites, including Plasmodium falciparum and Toxoplasma gondii, is a multistep process...
  50. pmc Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure
    C J Drakeley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Proc Natl Acad Sci U S A 102:5108-13. 2005
    ..We have compared the prevalence of IgG antibodies with three Plasmodium falciparum asexual stage antigens in individuals of all ages living at varying altitudes encompassing a range of ..
  51. pmc Initial evidence of reduction of malaria cases and deaths in Rwanda and Ethiopia due to rapid scale-up of malaria prevention and treatment
    Mac Otten
    World Health Organization, Global Malaria Program, Geneva, Switzerland
    Malar J 8:14. 2009
    ....
  52. pmc Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening
    Martin Smilkstein
    Medical Research Service, Department of Veterans Affairs Medical Center, Oregon Health and Science University, Portland, Oregon, USA
    Antimicrob Agents Chemother 48:1803-6. 2004
    ..assay and a standard radioisotopic method was performed by testing known antimalarial agents against Plasmodium falciparum strain D6...
  53. pmc Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2
    Arjen M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Med 2:e204. 2005
    In falciparum malaria sequestration of erythrocytes containing mature forms of Plasmodium falciparum in the microvasculature of vital organs is central to pathology, but quantitation of this hidden sequestered parasite load in vivo has ..
  54. pmc A progressive declining in the burden of malaria in north-eastern Tanzania
    Bruno P Mmbando
    National Institute for Medical Research, Tanga Centre, Tanga, Tanzania
    Malar J 9:216. 2010
    ..Recently, it has been reported that the burden of malaria in some parts of Africa has declined. However, community-based longitudinal data are sparse and the reasons for the apparent decline are not well understood...
  55. pmc Advances and challenges in malaria vaccine development
    Peter D Crompton
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Disease NIAID, NIH, Rockville, Maryland, USA
    J Clin Invest 120:4168-78. 2010
    Malaria caused by Plasmodium falciparum remains a major public health threat, especially among children and pregnant women in Africa...
  56. pmc Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern
    Mario Recker
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 7:e1001306. 2011
    ..In the human malaria parasite Plasmodium falciparum, this involves transcriptional switching among members of the var gene family, causing parasites with ..
  57. ncbi Artemisinins target the SERCA of Plasmodium falciparum
    U Eckstein-Ludwig
    Department of Cellular and Molecular Medicine, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Nature 424:957-61. 2003
    ..Artemisia annua) and are the most potent antimalarials available, rapidly killing all asexual stages of Plasmodium falciparum. Artemisinins are sesquiterpene lactones widely used to treat multidrug-resistant malaria, a disease that ..
  58. pmc New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq
    Thomas D Otto
    Parasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Mol Microbiol 76:12-24. 2010
    ..parallel sequencing to gain new insight into the transcriptome (RNA-Seq) of the human malaria parasite, Plasmodium falciparum. Using data collected at seven time points during the intraerythrocytic developmental cycle, we (i) detect ..
  59. pmc African great apes are natural hosts of multiple related malaria species, including Plasmodium falciparum
    Franck Prugnolle
    Laboratoire Génétique et Evolution des Maladies Infectieuses, Unité Mixte de Recherche 2724, Centre National de la Recherche Scientifique Institut de Recherche pour le Développement, Institut de Recherche pour le Développement Montpellier, 34394 Montpellier Cedex 5, France
    Proc Natl Acad Sci U S A 107:1458-63. 2010
    Plasmodium reichenowi, a chimpanzee parasite, was until very recently the only known close relative of Plasmodium falciparum, the most virulent agent of human malaria...
  60. pmc Serologic markers for detecting malaria in areas of low endemicity, Somalia, 2008
    Teun Bousema
    London School of Hygiene and Tropical Medicine, London, UK
    Emerg Infect Dis 16:392-9. 2010
    ..We evaluated serologic markers for detecting variation in malaria exposure in Somalia. Plasmodium falciparum or P...
  61. pmc On the diversity of malaria parasites in African apes and the origin of Plasmodium falciparum from Bonobos
    Sabrina Krief
    UMR 7206 USM 104, Eco anthropologie et Ethnobiologie, Museum national d histoire naturelle, Paris, France
    PLoS Pathog 6:e1000765. 2010
    The origin of Plasmodium falciparum, the etiological agent of the most dangerous forms of human malaria, remains controversial...
  62. pmc P. falciparum in vitro killing rates allow to discriminate between different antimalarial mode-of-action
    Laura M Sanz
    Tres Cantos Medicine Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
    PLoS ONE 7:e30949. 2012
    ..This approach has been adapted to perform medium throughput screening, facilitating the identification of fast-acting antimalarial compounds, which are crucially needed for the control and possibly the eradication of malaria...
  63. pmc Association of sub-microscopic malaria parasite carriage with transmission intensity in north-eastern Tanzania
    Alphaxard Manjurano
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
    Malar J 10:370. 2011
    ..The PCR prevalence was then compared against other measures of transmission intensity collected in the same area...
  64. pmc Infection intensity-dependent responses of Anopheles gambiae to the African malaria parasite Plasmodium falciparum
    Antonio M Mendes
    Division of Cell and Molecular Biology, Imperial College London, Exhibition Road, SW7 2AZ, London, UK
    Infect Immun 79:4708-15. 2011
    ..Here we investigate the transcriptional response of A. gambiae to geographically related Plasmodium falciparum populations at various infection intensities and different infection stages...
  65. ncbi Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum
    Wai Hong Tham
    Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Vic, Australia
    Trends Parasitol 28:23-30. 2012
    ..development of a highly efficacious vaccine that protects against disease and interrupts transmission of Plasmodium falciparum. It is likely that such a vaccine will be multi-component, with antigens from different stages of the ..
  66. pmc Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors
    Susanne H Sheehy
    Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom
    PLoS ONE 7:e31208. 2012
    Traditionally, vaccine development against the blood-stage of Plasmodium falciparum infection has focused on recombinant protein-adjuvant formulations in order to induce high-titer growth-inhibitory antibody responses...
  67. pmc Plasmodium vivax recurrence following falciparum and mixed species malaria: risk factors and effect of antimalarial kinetics
    Nicholas M Douglas
    Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Clin Infect Dis 52:612-20. 2011
    ..Plasmodium vivax malaria commonly follows treatment of falciparum malaria in regions of co-endemicity. This is an important cause of preventable morbidity...
  68. ncbi Protection against a malaria challenge by sporozoite inoculation
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    N Engl J Med 361:468-77. 2009
    ..Naturally acquired immunity to malaria develops slowly, and induction of protection in humans can be achieved artificially by the inoculation of radiation-attenuated sporozoites by means of more than 1000 infective mosquito bites...
  69. pmc Use of RDTs to improve malaria diagnosis and fever case management at primary health care facilities in Uganda
    Daniel J Kyabayinze
    Malaria Consortium Africa, Plot 2, Sturrock Road, PO Box 8045, Kampala, Uganda
    Malar J 9:200. 2010
    ..This study evaluated the effect of malaria RDTs on health workers' anti-malarial drug (AMD) prescriptions among outpatients at low level health care facilities (LLHCF) within different malaria epidemiological settings in Uganda...
  70. pmc Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites
    Shailja Singh
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    PLoS Pathog 6:e1000746. 2010
    ..We have used time-lapse video microscopy to study changes in intracellular calcium levels in Plasmodium falciparum merozoites during erythrocyte invasion...
  71. pmc Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome
    Lucy B Ochola
    KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Kilifi, Kenya
    PLoS ONE 6:e14741. 2011
    ..Our results show that increased binding to CD36 is associated with uncomplicated malaria while ICAM-1 adhesion is raised in parasites from cerebral malaria cases...
  72. pmc Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial
    Frank Smithuis
    Medecins Sans Frontieres Holland, Yangon, Myanmar
    Lancet Infect Dis 10:673-81. 2010
    ..We aimed to compare effectiveness of four fixed-dose ACTs and a loose tablet combination of artesunate and mefloquine, and assess the addition of a single gametocytocidal dose of primaquine...
  73. pmc Plasmodium falciparum var gene expression is modified by host immunity
    George M Warimwe
    Kenya Medical Research Institute Wellcome Trust Research Programme, 80108 Kilifi, Kenya
    Proc Natl Acad Sci U S A 106:21801-6. 2009
    b>Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a potentially important family of immune targets, which play a central role in the host-parasite interaction by binding to various host molecules...
  74. ncbi Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    H Jomaa
    Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Science 285:1573-6. 1999
    A mevalonate-independent pathway of isoprenoid biosynthesis present in Plasmodium falciparum was shown to represent an effective target for chemotherapy of malaria...
  75. pmc In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen
    David Plouffe
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 105:9059-64. 2008
    ..an efficient and robust high-throughput cell-based screen (1,536-well format) based on proliferation of Plasmodium falciparum (Pf) in erythrocytes. From a screen of approximately 1...
  76. pmc Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion
    Prakash Srinivasan
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 108:13275-80. 2011
    ..Collectively, these results identify the binding of RON2 to the hydrophobic pocket of AMA1 as the step that commits Plasmodium merozoites to RBC invasion and point to RON2 as a potential vaccine candidate...
  77. pmc Conditions of malaria transmission in Dakar from 2007 to 2010
    Libasse Gadiaga
    Institut de Recherche pour le Developpement, UMR 198, Unite Mixte de Recherche 6236, Route des Pères Maristes, BP 1386 Dakar, Senegal
    Malar J 10:312. 2011
    ..In order to improve the knowledge of the determinants of malaria transmission in this city, the present study reports the results of an extensive entomological survey that was conducted in 45 areas in Dakar from 2007 to 2010...
  78. pmc Midgut microbiota of the malaria mosquito vector Anopheles gambiae and interactions with Plasmodium falciparum infection
    Anne Boissière
    UMR MIVEGEC IRD 224 CNRS 5290 UM1 UM2, Montpellier, France
    PLoS Pathog 8:e1002742. 2012
    ..This striking relationship highlights the role of natural gut environment in parasite transmission. Deciphering microbe-pathogen interactions offers new perspectives to control disease transmission...
  79. pmc The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission
    Rita Tewari
    Institute of Genetics, QMC, University of Nottingham, Nottingham NG7 2UH, UK
    Cell Host Microbe 8:377-87. 2010
    Although eukaryotic protein kinases (ePKs) contribute to many cellular processes, only three Plasmodium falciparum ePKs have thus far been identified as essential for parasite asexual blood stage development...
  80. ncbi Cross-talk between T cells and NK cells generates rapid effector responses to Plasmodium falciparum-infected erythrocytes
    Amir Horowitz
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Immunol 184:6043-52. 2010
    ..study, we have characterized the kinetics and cellular sources of the very early IFN-gamma response to Plasmodium falciparum-infected RBCs among human PBMCs...
  81. pmc Plasmodium vivax and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea
    Blaise Genton
    Swiss Tropical Institute, Basel, Switzerland
    PLoS Med 5:e127. 2008
    Severe malaria (SM) is classically associated with Plasmodium falciparum infection. Little information is available on the contribution of P. vivax to severe disease. There are some epidemiological indications that P...
  82. pmc An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration
    G D Turner
    Molecular Parasitology Group, John Radcliffe Hospital, Oxford, UK
    Am J Pathol 145:1057-69. 1994
    ..parasitized erythrocytes in the microvasculature of vital organs is central to the pathogenesis of severe Plasmodium falciparum malaria...
  83. ncbi Impact of permethrin-treated bed nets on entomologic indices in an area of intense year-round malaria transmission
    John E Gimnig
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:16-22. 2003
    ..funestus were not significantly different between the two areas. We estimated the overall transmission of Plasmodium falciparum in intervention areas to be 90% lower than in control areas...
  84. ncbi A family affair: var genes, PfEMP1 binding, and malaria disease
    Susan M Kraemer
    Seattle Biomedical Research Institute, Seattle, WA 98109 5219, USA
    Curr Opin Microbiol 9:374-80. 2006
    An immunovariant adhesion protein family in Plasmodium falciparum named erythrocyte membrane protein 1 (PfEMP1), encoded by var genes, is responsible for both antigenic variation and cytoadhesion of infected erythrocytes at blood ..
  85. pmc Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs
    Jianbing Mu
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, Maryland, USA
    Nat Genet 42:268-71. 2010
    Antimalarial drugs impose strong selective pressure on Plasmodium falciparum parasites and leave signatures of selection in the parasite genome; screening for genes under selection may suggest potential drug or immune targets...
  86. pmc Artemisinin‐induced dormancy in plasmodium falciparum: duration, recovery rates, and implications in treatment failure
    Franka Teuscher
    Malaria Drug Resistance and Chemotherapy Laboratory, Queensland Institute of Medical Research, Australian Army Malaria Institute, Brisbane, Australia
    J Infect Dis 202:1362-8. 2010
    ..The temporary arrest of the growth of ring-stage parasites (dormancy) after exposure to artemisinin drugs provides a plausible explanation for this phenomenon...
  87. pmc Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A
    Michele D Spring
    United States Military Malaria Vaccine Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
    PLoS ONE 4:e5254. 2009
    ..the safety, immunogenicity, and efficacy of an experimental malaria vaccine comprised of the recombinant Plasmodium falciparum protein apical membrane antigen-1 (AMA-1) representing the 3D7 allele formulated with either the AS01B or ..
  88. pmc Rapid assessment of malaria transmission using age-specific sero-conversion rates
    Laveta Stewart
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    PLoS ONE 4:e6083. 2009
    ..This study evaluated SCR generated from samples collected from health facility attendees as a tool for a rapid assessment of malaria transmission intensity...
  89. pmc Plasmodium falciparum-infected erythrocytes induce NF-kappaB regulated inflammatory pathways in human cerebral endothelium
    Abhai K Tripathi
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Blood 114:4243-52. 2009
    ..processes, we investigated the global gene responses of human brain endothelium after the interaction with Plasmodium falciparum-infected erythrocytes with either high- or low-binding phenotypes...
  90. pmc Evaluation of the antigenic diversity of placenta-binding Plasmodium falciparum variants and the antibody repertoire among pregnant women
    Mirja Hommel
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Infect Immun 78:1963-78. 2010
    Pregnant women are infected by specific variants of Plasmodium falciparum that adhere and accumulate in the placenta...
  91. ncbi Enhancing blood-stage malaria subunit vaccine immunogenicity in rhesus macaques by combining adenovirus, poxvirus, and protein-in-adjuvant vaccines
    Simon J Draper
    Jenner Institute, University of Oxford, Oxford, OX3 7DQ, United Kingdom
    J Immunol 185:7583-95. 2010
    ..encoding blood-stage malaria Ags have shown efficacy in rodent malaria models and in vitro assays against Plasmodium falciparum. Abs and CD4(+) T cell responses are associated with protective efficacy against blood-stage malaria, ..
  92. pmc Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development
    Michelle J Boyle
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 107:14378-83. 2010
    During blood-stage infection by Plasmodium falciparum, merozoites invade RBCs...
  93. pmc Drug coverage in treatment of malaria and the consequences for resistance evolution--evidence from the use of sulphadoxine/pyrimethamine
    Allen L Malisa
    Department of Biological Sciences, Faculty of Science, Sokoine University of Agriculture, SUA, PO Box 3038, Morogoro, Tanzania
    Malar J 9:190. 2010
    ..These models show that where the basis of resistance is multigenic, the effects of selection can be moderated by high recombination rates, which disrupt the associations between co-selected resistance genes...
  94. ncbi Memory-like IFN-γ response by NK cells following malaria infection reveals the crucial role of T cells in NK cell activation by P. falciparum
    Matthew B B McCall
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Immunol 40:3472-7. 2010
    NK cells are rapid IFN-γ responders to Plasmodium falciparum-infected erythrocytes (PfRBC) in vitro and are involved in controlling early parasitaemia in murine models, yet little is known about their contribution to immune responses ..
  95. pmc Chromatin-mediated epigenetic regulation in the malaria parasite Plasmodium falciparum
    Liwang Cui
    Department of Entomology, Pennsylvania State University, 501 ASI Bldg, University Park, PA 16802, USA
    Eukaryot Cell 9:1138-49. 2010
    Malaria is a major public health problem in many developing countries, with the malignant tertian parasite Plasmodium falciparum causing the most malaria-associated mortality...
  96. ncbi Efficacy, safety, and selection of molecular markers of drug resistance by two ACTs in Mali
    Abdoulaye A Djimde
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, Bamako, Mali
    Am J Trop Med Hyg 78:455-61. 2008
    ..The ACTs were efficacious and safe, but the selection of markers for resistance to the partner drugs raises concerns over their lifespan in areas of intense malaria transmission...
  97. ncbi Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection
    Kent E Kester
    Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
    J Infect Dis 200:337-46. 2009
    ..To further increase the efficacy of malaria vaccine RTS,S/AS02A, we tested the RTS,S antigen formulated using the AS01B Adjuvant System (GlaxoSmithKline Biologicals)...
  98. pmc A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray
    Peter D Crompton
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    Proc Natl Acad Sci U S A 107:6958-63. 2010
    Abs are central to malaria immunity, which is only acquired after years of exposure to Plasmodium falciparum (Pf)...
  99. pmc A newly discovered protein export machine in malaria parasites
    Tania F de Koning-Ward
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3052, Australia
    Nature 459:945-9. 2009
    ..The trafficking machinery responsible for this export is unknown. Here we identify in Plasmodium falciparum a translocon of exported proteins (PTEX), which is located in the vacuole membrane...
  100. pmc Competitive facilitation of drug-resistant Plasmodium falciparum malaria parasites in pregnant women who receive preventive treatment
    W E Harrington
    Seattle Biomedical Research Institute, 307 Westlake Avenue N, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 106:9027-32. 2009
    Intermittent preventive treatment in pregnancy (IPTp) is used to prevent Plasmodium falciparum malaria...
  101. pmc Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data
    Vasee S Moorthy
    Initiative for Vaccine Research, World Health Organization, 1211 Geneva 27, Switzerland
    Malar J 8:312. 2009
    ..to review the information currently available about the vaccine with regard to how it impacts the human-Plasmodium falciparum host-pathogen relationship...

Research Grants83

  1. Falciparum malaria invasion ligand DNA/protein vaccine
    David Narum; Fiscal Year: 2002
    DESCRIPTION: (Provided by Applicant) The erythrocytic stage of Plasmodium falciparum (Pf) kills an estimated 2 million children annually...
  2. Vaccine Development for Falciparum Malaria in Pregnant Women and Their Offspring
    Ian C Michelow; Fiscal Year: 2013
    ..The objective of this proposal is to identify conserved Plasmodium falciparum antigens that are uniquely recognized by IgG antibodies in venous blood obtained at delivery from mothers ..
  3. Integrated Microfluidic Platform for Point-of-Care Serodiagnostics
    Xiaowu Liang; Fiscal Year: 2013
    ..non-biodefense targets including: Bartonella henselae, Borrelia burgdorferi, Hepatitis B Virus, Chlamydia, Plasmodium falciparum, Human papillomavirus, and Herpes simplex virus...
  4. Genomics of Antiviral Responses of Anopheles gambiae Against O'nyong-nyong Virus
    Young S Hong; Fiscal Year: 2010
    ..An. gambiae is a major vector for human malaria Plasmodium falciparum in Africa, but it is also a natural vector for O'nyong-nyong virus (ONNV) transmission...
  5. Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for Cerebr
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2012
    Cerebral malaria (CM) is a major complication of infection by Plasmodium falciparum. It affects mainly children under 5 years old in sub-Saharan Africa and shows a high mortality rate even when anti- malarial treatment is administered...
  6. Impacts of surface receptors [Toll like receptor (TLRs) and Fc gamma receptors (F
    Collins Ouma; Fiscal Year: 2012
    ..most common clinical manifestation of severe malaria in infants and young children living in holoendemic Plasmodium falciparum transmission areas...
  7. Cerebral Malaria: Mechanisms of disease and neurological salvage
    Mahalia S Desruisseaux; Fiscal Year: 2013
    ..Cerebral malaria is a form of severe malaria caused mainly by Plasmodium falciparum in humans...
  8. Insulin, IGF and Insulin Signaling: effects on Anopheles lifespan and immunity
    MICHAEL ALLEN RIEHLE; Fiscal Year: 2012
    ..in turn aging? 2) Does the midgut ISC affect signaling in other tissues? 3) Do changes to the ISC affect Plasmodium falciparum development? Finally, we will examine the impact of physiological levels of exogenous human insulin and ..
  9. Malaria and the safety of iron interventions: absorption and NTBI
    Gary M Brittenham; Fiscal Year: 2012
    This research will determine the effects of acute infection with Plasmodium falciparum on the absorption, pharmacokinetics and metabolism of iron from iron supplements and other Iron preparations in women of childbearing age...
  10. Development of Small Antimicrobial Peptide Mimics as Drug-Resistant and Susceptib
    Richard W Scott; Fiscal Year: 2013
    ..Moreover, drug resistant Plasmodium falciparum has become a major problem...
  11. Molecular epidemiology of drug resistance and population genetic structure of Pla
    Fangli Lu; Fiscal Year: 2013
    ..and the tropical Hainan Island of China, malaria has been the most endemic with high transmission of both Plasmodium falciparum and P. vivax...
  12. Pathogen-Specific Regulation of Protein Assembly
    ALLEN BERNARD REITZ; Fiscal Year: 2010
    ..enterocolitica to Plasmodium falciparum, Pseudomonas aeruginosa, Vibrio cholerae, and Toxoplasma gondii...
  13. A semi field trial test on efficacy of transgenic antimalarial biocontrol fungi
    Raymond J St Leger; Fiscal Year: 2013
    ..Faso with very high densities of the malaria vector Anopheles gambiae (up to 200 bites/person/night) and Plasmodium falciparum sporozoite rates around 3%...
  14. Development of a Chloroquine Replacement Drug
    MICHAEL KEVIN RISCOE; Fiscal Year: 2010
    ..which we refer to as "Pharmachins" with equal and potent activity against multidrug resistant strains of Plasmodium falciparum including strains harboring high level resistance to chloroquine, quinine, mefloquine, Fansidar and ..
  15. The role of the interaction between the C-terminal domain of RNA pol II and a his
    Uchechi E Ukaegbu; Fiscal Year: 2012
    ..of RNA pol II and a histone methyltransferase in mediating epigenetic memory in malaria virulence genes Plasmodium falciparum is responsible for the most acute and severe form of human malaria...
  16. Role of Protective and Pathogenic B cells in Modulating Pediatric Severe Malaria
    Tom Were; Fiscal Year: 2013
    ..most common clinical manifestation of severe malaria in infants and young children living in holoendemic Plasmodium falciparum transmission areas...
  17. Arginine, Nitric Oxide, and Severe Malaria
    JOE BRICE WEINBERG; Fiscal Year: 2012
    ..NO has antimicrobial effects in vitro against a wide variety of organisms including Plasmodium falciparum, and it can modulate endothelial function (reduction of cell adhesion molecule expression and adherence of ..
  18. Identification of G6PD inhibitors for the development of novel antimalarial drugs
    Lars Bode; Fiscal Year: 2010
    Tropical malaria, caused by the parasite Plasmodium falciparum, is responsible for up to three million deaths each year...
  19. Pilot studies of the molecular epidemiology of drug-resistant malaria in Myanmar
    Christopher V Plowe; Fiscal Year: 2013
    ..The World Health Organization (WHO) is coordinating an aggressive effort to contain artemisinin resistant Plasmodium falciparum malaria in Southeast Asia before it spreads from its recent site of emergence in Western Cambodia...
  20. FOSMIDOMYCIN RESISTANCE IN PLASMODIUM FALCIPARUM
    AUDREY RAGAN ODOM; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Plasmodium falciparum is a protozoan pathogen that causes the deadliest form of malaria. Malaria has a tremendous impact on human health worldwide, causing nearly one million deaths per year...
  21. Malaria treatment outcomes and pharmacokinetics in HIV-infected pregnant women
    MYAING MYAING NYUNT; Fiscal Year: 2010
    ..recommended by the World Health Organization (WHO) for the treatment of uncomplicated malaria caused by Plasmodium falciparum. High treatment efficacy, good tolerability, and an acceptable safety profile of artemether-lumefantrine ..
  22. Purine Pathways and Inhibitor Design in Plasmodium
    Vern L Schramm; Fiscal Year: 2012
    b>Plasmodium falciparum is the leading cause of death from malaria, taking the lives of over a million children and causing clinical illness in 300 to 500 million people each year...
  23. Determinants of growth and fitness in drug resistant malaria parasites
    Michael T Ferdig; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The malaria parasite, Plasmodium falciparum, continues to devastate human health...
  24. A cell-based HTS for delayed death inhibitors of the malarial parasite plastid
    DAVID FIDOCK; Fiscal Year: 2009
    b>Plasmodium falciparum, an Apicomplexan parasite and the causal agent of severe malaria, causes disease in over 500 million individuals and kills over one million children yearly...
  25. Attenuated malaria sporozoite vaccine using a P. falciparum blood-stage auxotroph
    STEPHEN LEV HOFFMAN; Fiscal Year: 2013
    ..that targets the asymptomatic sporozoite (SPZ) and liver stages of the most lethal human malaria parasite, Plasmodium falciparum (Pf), would be an ideal tool to prevent malaria infection, disease and transmission...
  26. ROLE OF COMPLEMENT RECEPTOR 1 IN ERYTHROCYTE INVASION BY PLASMODIUM FALCIPARUM IN
    GORDON AKANZUWINE AWANDARE; Fiscal Year: 2013
    ....
  27. P.falciparum var gene diversity and malaria control
    KAREN PATRICIA DAY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The burden of Plasmodium falciparum malaria is enormous with up to a million deaths per annum and billions of infections that persist for many months in the human population...
  28. Functional genomic analysis of host determinants of malaria infection
    Elizabeth Egan; Fiscal Year: 2013
    ..available in endemic areas, their utility is compromised by the rapid development of drug resistance by Plasmodium falciparum parasites...
  29. T Cell Immunity in Endemic Burkitt Lymphoma
    Ann M Moormann; Fiscal Year: 2012
    ..Epidemiologic studies of eBL indicate a strong association with Plasmodium falciparum malaria and Epstein-Barr virus (EBV) infections early in childhood...
  30. Var gene regulation and antigenic variation in malaria
    Kirk W Deitsch; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Plasmodium falciparum is the causative agent responsible for the most severe form of human malaria, a disease that kills more than a million people a year, mostly young children in Africa...
  31. Chemokines in Zambian children with Cerebral Malaria
    Monique F Stins; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cerebral malaria (CM) is a clinical syndrome associated with Plasmodium falciparum infection that is associated with a high mortality of up to 30%, particular in children...
  32. Identification of serine hydrolases involved in Plasmodium host cell invasion
    Brooke Anderson-White; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Plasmodium falciparum is the parasite responsible for malaria, a disease that continues to devastate all tropical regions of the world...
  33. The Plasmodium 2TM and PHIST protein families
    Thomas J Templeton; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The human malaria parasite, Plasmodium falciparum, possesses a broad repertoire of proteins that are proposed to be trafficked to the erythrocyte cytoplasm or surface, based upon the presence within ..
  34. A Heterologous Expression System for Apicomplexa Genes
    JOSE A FERNANDEZ ROBLEDO; Fiscal Year: 2010
    ..The apicomplexan Plasmodium falciparum is the ethiological agent of Malaria and can cause high mortality and morbidity in endemic areas...
  35. Neuropathology of severe malaria in Thailand: MRI studies
    Gary M Brittenham; Fiscal Year: 2011
    ..Worldwide, the most important parasitic disease infecting the central nervous system of humans is Plasmodium falciparum malaria...
  36. Predicting naturally acquired humoral immunity against malaria
    PHILIP LOUIS FELGNER; Fiscal Year: 2013
    ..People living in areas of intense Plasmodium falciparum (Pf) transmission develop resistance to the symptoms of malaria after repeated exposures to Pf parasite ..
  37. Analysis of novel in vivo derived Plasmodium falciparum transcriptional profiles
    JOHANNA PATRICIA DAILY; Fiscal Year: 2012
    ABSTRACT Infection with the malaria parasite Plasmodium falciparum leads to widely different clinical conditions in children [unreadable]ranging from mild flu-like symptoms to coma and death...
  38. Innate Immune Activation in Malaria
    Douglas T Golenbock; Fiscal Year: 2013
    ..is to identify the molecular mechanisms of systemic inflammation and fever in individuals infected with Plasmodium falciparum. Our preliminary data demonstrate that malaria DNA, especially when complexed to the malarial pigment ..
  39. Multi-stage multi-antigen Vaccine for interrupting Malaria Transmission
    B Kim Lee Sim; Fiscal Year: 2013
    ..development is based on the observation that immunization via bites of irradiated mosquitoes infected with Plasmodium falciparum (Pf) sporozoites (SPZ) provides high-level protection...
  40. Malaria transmission potential of the Anopheles punctutatus species complex
    Lisa Reimer; Fiscal Year: 2013
    ..will be experimentally infected by feeding them with a sample of blood containing a known number of either Plasmodium falciparum or P. vivax gametocytes...
  41. Multi-ligand merozoite invasion blocking malaria vaccine
    B Kim Lee Sim; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Malaria caused by Plasmodium falciparum (Pf) results in more than 250 million clinical cases, and nearly one million deaths annually...
  42. Regulation of Plasmodium falciparum transcription
    Manuel Llinas; Fiscal Year: 2013
    ..understand the molecular mechanisms involved in transcriptional regulation in the malaria-causing parasite Plasmodium falciparum. During the malaria infection, the red blood cell stage of Plasmodium development is responsible for all ..
  43. Microparticles, a new player in cerebral malaria pathogenesis
    VALERY MADELEINE COMBES; Fiscal Year: 2013
    ..barrier (BBB), we observed that MPs are potent activators of monocytes and facilitate the adhesion of Plasmodium falciparum-parasitized RBCs (Pf-pRBCs) to human brain endothelial cell (HBEC) monolayers in vitro by adhering to ..
  44. Ecology of African Highland Malaria
    Guiyun Yan; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Since the late 1980s, a series of Plasmodium falciparum malaria epidemics have occurred in the highlands of African countries...
  45. Identification of vaccine candidates against severe malaria
    Andrew V Oleinikov; Fiscal Year: 2013
    ..b>Plasmodium falciparum parasite-infected erythrocytes (IE) adhere to the host endothelium and to red blood cells...
  46. Oral Immunization Against Malaria with Recombinant Adenoviruses
    GARY W KETNER; Fiscal Year: 2010
    ..Recombinant vaccine candidates will express pre-erythrocytic Plasmodium falciparum antigens that induce protective immunity in primates: circumsporozoite protein (PfCSP) and liver stage ..
  47. MAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUM
    Tim J Anderson; Fiscal Year: 2013
    ..provided by applicant): Artemisinin combination therapies (ACTs) are the mainstay of treatment for Plasmodium falciparum. However, slow clearance of parasites from the blood following treatment with ACTs in some SE Asian ..
  48. Vaccination with purified, cryopreserved, infectious Plasmodium vivax sporozoites
    STEPHEN LEV HOFFMAN; Fiscal Year: 2013
    ..In a seminal paper it was shown that immunization by the bite of mosquitoes carrying fully infectious Plasmodium falciparum sporozoites (PfSPZ) of volunteers taking chloroquine induced 100% protective immunity, and protection was ..
  49. EXPRESSION OF EXOGENOUS GENES IN VECTOR MOSQUITOES
    Anthony A James; Fiscal Year: 2013
    ..The Specific Aims are 1) optimize expression of single-chain antibodies (scFv) that disable Plasmodium falciparum In the midgut and hemolymph of transgenic Anopheles stephensi;2) construct and test in parasite-challenge ..
  50. ROLE OF CHAPERONES IN MAINTAINING THE ASPARAGINE REPEAT-RICH PROTEOME OF P. FALCI
    Vasant Muralidharan; Fiscal Year: 2012
    ..b>Plasmodium falciparum is a deadly human pathogen that is responsible for over a million deaths every year. The proteome of P...
  51. Targeting DXP Synthase in Non-mammalian Isoprenoid Biosynthesis
    FRANCINE M MORRIS; Fiscal Year: 2012
    ..Several human pathogens, including Mycobacterium tuberculosis and the malaria parasite, Plasmodium falciparum utilize a pathway for isoprenoid biosynthesis that is absent in mammals known as the methylerythritol ..
  52. Dissecting a novel mechanism of drug-induced death in Toxoplasma gondii
    GUSTAVO A ARRIZABALAGA; Fiscal Year: 2013
    ..The Apicomplexa comprise a medically important phylum of obligate intracellular parasites, including Plasmodium falciparum, the causative agent of malaria, Cryptosporidium, which causes gastrointestinal disease, and the category ..
  53. An.gambiae immune signaling gene SNPs and natural P. falciparum infection
    Shirley Luckhart; Fiscal Year: 2013
    ..We will pursue this goal through two specific aims. The first Aim includes population genetic analyses. Plasmodium falciparum infected and uninfected An. gambiae will be collected from sites in Mali and Cameroon...
  54. Identification of responding CD8+ T cells and novel protective epitopes following
    SEAN CHRISTOPHER MURPHY; Fiscal Year: 2013
    ..However, vaccination with the subunit RTS,S/AS02 vaccine encoding the Plasmodium falciparum circumsporozoite protein significantly reduced deaths due to severe malaria in Africa children and ..
  55. Mitochondrial Functions in Malaria Parasites
    Akhil B Vaidya; Fiscal Year: 2013
    ..We showed that a critical function of mtETC in Plasmodium falciparum blood stages was to serve as an electron disposal system for the mitochondrially located dihydroorotate ..
  56. Endothelial progenitor cells and the pathogenesis of cerebral malaria
    BEN ADU GYAN; Fiscal Year: 2013
    ..The majority of deaths are due to infections with Plasmodium falciparum (P. falciparum). Cerebral malaria (CM) is a major cause of death in these patients...
  57. Immunizing Against Malaria by Inducing Both Protective Antibodies and CD8 T Cells
    B Kim Lee Sim; Fiscal Year: 2013
    ..This vaccine is based entirely on the repeat region and carboxy terminus of the Plasmodium falciparum (Pf) circumsporozoite protein (CSP)...
  58. Chemical Genetics of Plasmodium Kinases
    Debopam Chakrabarti; Fiscal Year: 2010
    ..will fundamentally advance our understanding of the molecular mechanisms of PfPK5 function in regulating Plasmodium falciparum intraerythrocytic life cycle...
  59. Functional Role of the Tetraspanin CD82/Kai1 in Innate and Adaptive Immunity
    Jatin M Vyas; Fiscal Year: 2013
    ..Diverse pathogens including HIV-1, E. coli, Plasmodium falciparum and Candida albicans all manipulate mammalian tetraspanins for cell invasion or intracellular trafficking...
  60. VACCINE INDUCED IMMUNE RESPONSES TO PLASMODIAL ANTIGENS
    JAMES MATTHEW BURNS; Fiscal Year: 2012
    The need for an efficacious vaccine to reduce malaria morbidity and mortality due to Plasmodium falciparum is widely recognized and urgent. For malaria endemic areas, such a vaccine must target blood- stage parasites...
  61. Perturbations of host cell signaling by a complex hepatotropic pathogen
    Stefan H I Kappe; Fiscal Year: 2013
    ..in response to rodent malaria infection, but also in response to the most deadly human malaria parasite, Plasmodium falciparum, using infected hepatocytes from a mouse with a humanized liver...
  62. ROLE OF CHAPERONES IN MAINTAINING THE ASPARAGINE REPEAT-RICH PROTEOME OF P. FALCI
    Vasant Muralidharan; Fiscal Year: 2013
    Project Summary/Abstract Plasmodium falciparum is a deadly human pathogen that is responsible for over a million deaths every year. The proteome of P...
  63. Essential gene discovery in the malaria parasite Plasmodium falciparum
    Jeffrey D Dvorin; Fiscal Year: 2013
    ..The most severe forms of malaria result from infection by the Plasmodium falciparum parasite, which causes the vast majority of malaria in Africa...
  64. Azithromycin Combination Therapy in Resistant Malaria
    Charles Knirsch; Fiscal Year: 2000
    The emergence of in vivo resistance of Plasmodium falciparum malaria to standard antimalarial drugs is a major and growing threat to public health in Africa, Asia, and Latin America. Chloroquine treatment is now rarely effective...
  65. Lyophilization of Plasmodium falciparum sporozoite vaccine
    Stephen Hoffman; Fiscal Year: 2007
    ..When attenuated Plasmodium falciparum sporozoites (PfSPZ) are administered by bite of infected mosquitoes >90% of human volunteers are ..
  66. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2003
    ..7 million deaths in Africa each year. In vitro resistance to the antifolates in Plasmodium falciparum is caused by point mutations in the enzymes targeted by these drugs, dihydrofolate reductase (DHFR) and ..
  67. Improving Production of Attenuated Malaria Sporozoite Vaccines through Genetic Mo
    Peter Billingsley; Fiscal Year: 2009
    ..Sanaria's goal is to develop and commercialize a >90% protective attenuated Plasmodium falciparum (Pf) sporozoite (SPZ) vaccine for two primary markets with potential annual revenues >$1 billion, ..
  68. IMPACT OF TS PROPHYLAXIS ON ANTIFOLATE RESISTANT MALARIA
    James Kublin; Fiscal Year: 2000
    ..Resistance to the antifolates in Plasmodium falciparum is caused by point mutations in dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS)...
  69. AZITHROMYCIN TREATMENT FOR DRUG-RESISTANT MALARIA
    Jonathan Berman; Fiscal Year: 2000
    The emergence of in vivo resistance of Plasmodium falciparum malaria to standard antimalarial drugs is a major and growing threat to public health in Africa, Asia, and Latin America...
  70. Indirect aminoacylation in the Plasmodium apicoplast
    MALCOLM JOHN GARDNER; Fiscal Year: 2010
    The human malaria parasite Plasmodium falciparum is responsible for 300-500 million cases of malaria and 1.3 million deaths every year...
  71. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2005
    ..b>Plasmodium falciparum malaria remains a devastating cause of morbidity and mortality in sub-Saharan Africa...
  72. SP resistance markers & falciparum malaria transmission
    Fabian Mendez; Fiscal Year: 2004
    Drug-resistant Plasmodium falciparum is a major threat to global public health and new strategies are needed to deter spread of resistance to available and forthcoming antimalarial drugs...
  73. Role of Red Cell Membrane in Malaria Parasite Release
    Manjit Hanspal; Fiscal Year: 2006
    b>Plasmodium falciparum causes the most severe form of human malaria...
  74. Potency of cryopreserved, irradiated sporozoite vaccine
    Stephen Hoffman; Fiscal Year: 2005
    ..Sanada's goal is to develop and commercialize an attenuated Plasmodium falciparum sporozoite vaccine for two primary markets with a potential for > $1 billion annual revenues; 1) ..
  75. Molecular determinants of P. falciparum resistance to ACTs in Nigeria.
    Christian T Happi; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The rapid development and spread of drug resistant Plasmodium falciparum is a serious global health problem and has contributed to increased mortality and morbidity caused by malaria...
  76. DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2002
    The emergence of in vivo resistance of Plasmodium falciparum malaria to chloroquine and to the combination antifolate drug pyrimethamine-sulfadoxine (PS) is a major threat to public health in Africa...
  77. Cerebral Malaria Associated Neurological Disorders in India
    Jonathan Stiles; Fiscal Year: 2005
    b>Plasmodium falciparum is the most common parasite to infect central nervous system and the leading cause of diffuse encephalopathy in young children...
  78. ERYTHROCYTE ADHESION IN FALCIPARUM MALARIA
    IRWIN SHERMAN; Fiscal Year: 2004
    b>Plasmodium falciparum contributes to 1.5-2.7 million deaths annually. Cerebral malaria, a complication of P...
  79. CR1 Polymorphisms and Susceptibility to Severe Malaria
    JOANN MOULDS; Fiscal Year: 2002
    DESCRIPTION (provided by the applicant): Plasmodium falciparum malaria is one of the most important infectious diseases affecting the human population and is a multi-factorial process influenced by both parasite virulence factors and ..
  80. Dual Function Acridones as A New Antimalarial Chemotype
    Jane X Kelly; Fiscal Year: 2010
    ..situation is largely attributed to and aggravated by the emergence and spread of multi-drug resistant Plasmodium falciparum, the cause of the most deadly form of malaria...
  81. Molecular epidemiology of sulfadoxine-pyrimethamine
    Thomas Egwang; Fiscal Year: 2006
    ..a considerable public health burden and the problem is exacerbated by the emergence of drug-resistant Plasmodium falciparum strains...
  82. Molecular Mechanisms of Plasmodium Falciparum Adherence to the Human Placenta
    Susan J Fisher; Fiscal Year: 2010
    ..PM is defined as (1) the accumulation of Plasmodium falciparum-infected red blood cells (iRBCs) in the maternal blood spaces of the placenta, and (2) the cytoadherence ..
  83. DNA BASE EXCISION REPAIR IN PLASMODIUM FALCIPARUM
    THEODORE TARASCHI; Fiscal Year: 2005
    ..The replication and control of DNA repair in Plasmodium falciparum are likely to have a number of differences from the mammalian cell...