toxoplasma

Summary

Summary: A genus of protozoa parasitic to birds and mammals. T. gondii is one of the most common infectious pathogenic animal parasites of man.

Top Publications

  1. pmc Toxoplasma gondii: from animals to humans
    A M Tenter
    Institut für Parasitologie, Tierarztliche Hochschule Hannover, Bunteweg 17, D 30559, Hannover, Germany
    Int J Parasitol 30:1217-58. 2000
  2. ncbi Toxoplasmosis
    J G Montoya
    Department of Medicine and Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Lancet 363:1965-76. 2004
  3. pmc Toxoplasma gondii infection in humans in China
    Peng Zhou
    State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province, P R China
    Parasit Vectors 4:165. 2011
  4. pmc Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80
    My Hang Huynh
    Department of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Eukaryot Cell 8:530-9. 2009
  5. pmc Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue
    J P J Saeij
    Department of Microbiology and Immunology, Fairchild Building D305, 300 Pasteur Drive, Stanford University School of Medicine, Stanford, California 94305 5124, USA
    Nature 445:324-7. 2007
  6. ncbi TigrScan and GlimmerHMM: two open source ab initio eukaryotic gene-finders
    W H Majoros
    Bioinformatics Department, The Institute for Genomic Research, Rockville, MD 20850, USA
    Bioinformatics 20:2878-9. 2004
  7. pmc The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites' boundaries
    Moritz Treeck
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Host Microbe 10:410-9. 2011
  8. pmc Modulation of innate immunity by Toxoplasma gondii virulence effectors
    Christopher A Hunter
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Nat Rev Microbiol 10:766-78. 2012
  9. pmc Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii
    Tobias Steinfeldt
    Institute for Genetics, University of Cologne, Cologne, Germany
    PLoS Biol 8:e1000576. 2010
  10. pmc Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages
    Chunlei Su
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    Proc Natl Acad Sci U S A 109:5844-9. 2012

Detail Information

Publications375 found, 100 shown here

  1. pmc Toxoplasma gondii: from animals to humans
    A M Tenter
    Institut für Parasitologie, Tierarztliche Hochschule Hannover, Bunteweg 17, D 30559, Hannover, Germany
    Int J Parasitol 30:1217-58. 2000
    Toxoplasmosis is one of the more common parasitic zoonoses world-wide. Its causative agent, Toxoplasma gondii, is a facultatively heteroxenous, polyxenous protozoon that has developed several potential routes of transmission within and ..
  2. ncbi Toxoplasmosis
    J G Montoya
    Department of Medicine and Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Lancet 363:1965-76. 2004
    b>Toxoplasma gondii is a protozoan parasite that infects up to a third of the world's population...
  3. pmc Toxoplasma gondii infection in humans in China
    Peng Zhou
    State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province, P R China
    Parasit Vectors 4:165. 2011
    Toxoplasmosis is a zoonotic infection of humans and animals, caused by the opportunistic protozoan Toxoplasma gondii, a parasite belonging to the phylum Apicomplexa...
  4. pmc Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80
    My Hang Huynh
    Department of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Eukaryot Cell 8:530-9. 2009
    ..genome sequence, opportunities for performing large-scale studies, such as expression and localization, on Toxoplasma gondii are now much more feasible...
  5. pmc Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue
    J P J Saeij
    Department of Microbiology and Immunology, Fairchild Building D305, 300 Pasteur Drive, Stanford University School of Medicine, Stanford, California 94305 5124, USA
    Nature 445:324-7. 2007
    b>Toxoplasma gondii, an obligate intracellular parasite of the phylum Apicomplexa, can cause severe disease in humans with an immature or suppressed immune system...
  6. ncbi TigrScan and GlimmerHMM: two open source ab initio eukaryotic gene-finders
    W H Majoros
    Bioinformatics Department, The Institute for Genomic Research, Rockville, MD 20850, USA
    Bioinformatics 20:2878-9. 2004
    ..Both programs have been used at TIGR for the annotation of the Aspergillus fumigatus and Toxoplasma gondii genomes.
  7. pmc The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites' boundaries
    Moritz Treeck
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Host Microbe 10:410-9. 2011
    Plasmodium falciparum and Toxoplasma gondii are obligate intracellular apicomplexan parasites that rapidly invade and extensively modify host cells...
  8. pmc Modulation of innate immunity by Toxoplasma gondii virulence effectors
    Christopher A Hunter
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Nat Rev Microbiol 10:766-78. 2012
    b>Toxoplasma gondii is a common parasite of animals and humans and can cause serious opportunistic infections...
  9. pmc Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii
    Tobias Steinfeldt
    Institute for Genetics, University of Cologne, Cologne, Germany
    PLoS Biol 8:e1000576. 2010
    ..and analyse just such a case at the molecular level, involving the widespread intracellular protozoan pathogen Toxoplasma gondii and one of its most important natural hosts, the house mouse (Mus musculus)...
  10. pmc Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages
    Chunlei Su
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    Proc Natl Acad Sci U S A 109:5844-9. 2012
    Marked phenotypic variation characterizes isolates of Toxoplasma gondii, a ubiquitous zoonotic parasite that serves as an important experimental model for studying apicomplexan parasites...
  11. pmc Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection
    Guillaume Oldenhove
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 31:772-86. 2009
    Using a model of lethal oral infection with Toxoplasma gondii, we examined the fate of both induced and natural regulatory T (Treg) cells in the face of strong inflammatory responses occurring in a tolerogenic-prone environment...
  12. pmc Conditional genome engineering in Toxoplasma gondii uncovers alternative invasion mechanisms
    Nicole Andenmatten
    Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
    Nat Methods 10:125-7. 2013
    ..recombination system based on dimerizable Cre recombinase-mediated recombination in the apicomplexan parasite Toxoplasma gondii...
  13. pmc Genetic analyses of atypical Toxoplasma gondii strains reveal a fourth clonal lineage in North America
    Asis Khan
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Parasitol 41:645-55. 2011
    b>Toxoplasma gondii is a widespread parasite of animals that causes zoonotic infections in humans...
  14. pmc Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it
    Sebastian Virreira Winter
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America
    PLoS ONE 6:e24434. 2011
    IFN-γ is a major cytokine that mediates resistance against the intracellular parasite Toxoplasma gondii. The p65 guanylate-binding proteins (GBPs) are strongly induced by IFN-γ...
  15. pmc Seroprevalence of Toxoplasma gondii infection in household and stray cats in Lanzhou, northwest China
    Song Ming Wu
    College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu Province, PR China
    Parasit Vectors 4:214. 2011
    b>Toxoplasma gondii is an important protozoan parasite infecting humans and almost all warm-blooded animals. As the only definitive host, cats play a crucial role in the transmission of T...
  16. doi Immunology of Toxoplasma gondii
    Melba Munoz
    Charite Medical School Berlin Microbiology and Hygiene, Berlin, Germany
    Immunol Rev 240:269-85. 2011
    b>Toxoplasma gondii is an obligate intracellular parasite. Following oral infection the parasite crosses the intestinal epithelial barrier to disseminate throughout the body and establish latent infection in central nervous tissues...
  17. pmc Identification of the moving junction complex of Toxoplasma gondii: a collaboration between distinct secretory organelles
    David L Alexander
    Department of Microbiology and Immunology, Stanford University, Stanford, California, USA
    PLoS Pathog 1:e17. 2005
    Apicomplexan parasites, including Toxoplasma gondii and Plasmodium sp., are obligate intracellular protozoa. They enter into a host cell by attaching to and then creating an invagination in the host cell plasma membrane...
  18. pmc Targeted proteomic dissection of Toxoplasma cytoskeleton sub-compartments using MORN1
    Alexander Lorestani
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    Cytoskeleton (Hoboken) 69:1069-85. 2012
    The basal complex in Toxoplasma functions as the contractile ring in the cell division process. Basal complex contraction tapers the daughter cytoskeleton toward the basal end and is required for daughter segregation...
  19. doi Innate immunity to Toxoplasma gondii infection
    Felix Yarovinsky
    Department of Immunology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9093, USA
    Nat Rev Immunol 14:109-21. 2014
    b>Toxoplasma gondii is a protozoan parasite of global importance. In the laboratory setting, T. gondii is frequently used as a model pathogen to study mechanisms of T helper 1 (TH1) cell-mediated immunity to intracellular infections...
  20. pmc CD11c- and CD11b-expressing mouse leukocytes transport single Toxoplasma gondii tachyzoites to the brain
    Nathalie Courret
    Departement des Maladies Infectieuses, Institut Cochin, Institut National de la Santé et de la Recherche Médicale U567 Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, 22 rue Mechain, 75014 Paris, France
    Blood 107:309-16. 2006
    The protozoan parasite Toxoplasma gondii enters hosts through the intestinal mucosa and colonizes distant tissues such as the brain, where its progeny persists for a lifetime...
  21. pmc A conserved non-canonical motif in the pseudoactive site of the ROP5 pseudokinase domain mediates its effect on Toxoplasma virulence
    Michael L Reese
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305 5124, USA
    J Biol Chem 286:29366-75. 2011
    The ROP5 family is a closely related set of polymorphic pseudokinases that are critical to the ability of Toxoplasma to cause disease. Polymorphisms in ROP5 also make it a major determinant of strain-specific differences in virulence...
  22. pmc Toxoplasma gondii sequesters centromeres to a specific nuclear region throughout the cell cycle
    Carrie F Brooks
    Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 108:3767-72. 2011
    ..How this complex process is coordinated remains poorly understood. Using Toxoplasma gondii as a genetic model, we show that a key element to this coordination is the centrocone, a unique ..
  23. doi Toxoplasma gondii infection in humans and animals in the United States
    J P Dubey
    United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Animal Parasitic Diseases Laboratory, Beltsville, MD 20705 2350, USA
    Int J Parasitol 38:1257-78. 2008
    This paper reviews clinical and asymptomatic Toxoplasma gondii infection in humans and other animals in the USA. Seroprevalence of T. gondii in humans and pigs is declining...
  24. pmc Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complex
    Thomas Nebl
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    PLoS Pathog 7:e1002222. 2011
    ..We have characterized calcium-dependent phosphorylation events during Toxoplasma host cell invasion...
  25. pmc Toxoplasma gondii triggers release of human and mouse neutrophil extracellular traps
    Delbert S Abi Abdallah
    Department of Microbiology and Immunology, Cornell University, Ithaca, New York, USA
    Infect Immun 80:768-77. 2012
    ..Here, we show that the protozoan pathogen Toxoplasma gondii elicits the production of NETs from human and mouse neutrophils...
  26. ncbi Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    Jason S Stumhofer
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6008, USA
    Nat Immunol 7:937-45. 2006
    ..Here we show that IL-27 receptor-deficient mice chronically infected with Toxoplasma gondii developed severe neuroinflammation that was CD4+ T cell dependent and was associated with a prominent IL-..
  27. pmc Epidemiology of and diagnostic strategies for toxoplasmosis
    Florence Robert-Gangneux
    Service de Parasitologie, Faculté de Médecine et Centre Hospitalier Universitaire de Rennes, Rennes, France
    Clin Microbiol Rev 25:264-96. 2012
    The apicomplexan parasite Toxoplasma gondii was discovered a little over 100 years ago, but knowledge of its biological life cycle and its medical importance has grown in the last 40 years...
  28. pmc Efficient gene replacements in Toxoplasma gondii strains deficient for nonhomologous end joining
    Barbara A Fox
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Eukaryot Cell 8:520-9. 2009
    ..of nonhomologous recombination has hampered gene targeting approaches in the model apicomplexan parasite Toxoplasma gondii...
  29. pmc Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategy
    Adam James Reid
    Wellcome Trust Sanger Institute, Hinxton, Cambridgshire, United Kingdom
    PLoS Pathog 8:e1002567. 2012
    b>Toxoplasma gondii is a zoonotic protozoan parasite which infects nearly one third of the human population and is found in an extraordinary range of vertebrate hosts...
  30. pmc Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence
    Sarah J Fentress
    Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63130, USA
    Cell Host Microbe 8:484-95. 2010
    ..Here we demonstrate that the obligate intracellular parasite Toxoplasma gondii disarms macrophage innate clearance mechanisms by secreting a serine threonine kinase called ROP18, which ..
  31. ncbi Evasion of innate immunity by parasitic protozoa
    David Sacks
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Immunol 3:1041-7. 2002
    ..In addition, there is growing evidence that protozoan pathogens modify the antigen-presenting and immunoregulatory functions of dendritic cells, a process that facilitates their evasion of both innate and adaptive immunity...
  32. pmc CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites
    Mona Mashayekhi
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Immunity 35:249-59. 2011
    ..Additionally, secretion of interleukin-12 (IL-12) by CD8α(+) DCs suggests a role for these cells in response to Toxoplasma gondii antigens, although it remains unclear whether these cells are required for protection against T...
  33. ncbi Induction of dendritic cell migration upon Toxoplasma gondii infection potentiates parasite dissemination
    Henrik Lambert
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Cell Microbiol 8:1611-23. 2006
    The processes leading to systemic dissemination of the obligate intracellular parasite Toxoplasma gondii remain unelucidated...
  34. pmc Dynamics of neutrophil migration in lymph nodes during infection
    Tatyana Chtanova
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720, USA
    Immunity 29:487-96. 2008
    ..to examine neutrophil migration in intact lymph nodes during infection with an intracellular parasite, Toxoplasma gondii...
  35. ncbi Toxoplasma gondii: transmission, diagnosis and prevention
    D Hill
    Animal and Natural Resources Institute, Agricultural Research Service, US Department of Agriculture, Beltsville, Maryland 20705 2350, USA
    Clin Microbiol Infect 8:634-40. 2002
    Toxoplasmosis, caused by the protozoan parasite Toxoplasma gondii, is one of the most common parasitic infections of man and other warm-blooded animals. It has been found world-wide from Alaska to Australia...
  36. pmc Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of Toxoplasma gondii
    Michael S Behnke
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana, USA
    PLoS ONE 5:e12354. 2010
    ....
  37. pmc A family of intermediate filament-like proteins is sequentially assembled into the cytoskeleton of Toxoplasma gondii
    Brooke R Anderson-White
    Department of Biology, Boston College, Chestnut Hill, MA, USA
    Cell Microbiol 13:18-31. 2011
    The intracellular protozoan parasite Toxoplasma gondii divides by a unique process of internal budding that involves the assembly of two daughter cells within the mother...
  38. pmc Severe acquired toxoplasmosis in immunocompetent adult patients in French Guiana
    B Carme
    Parasitologie Mycologie, EA 3593 UFR de Médecine Université Antilles Guyane et Centre Hospitalier de Cayenne Service de Médecine B, Centre Hospitalier de Cayenne, F 97306 Cayenne, France
    J Clin Microbiol 40:4037-44. 2002
    ..b>Toxoplasma strains, which were virulent in mice, were isolated from three patients...
  39. pmc A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation
    Laurence Braun
    Centre National de la Recherche Scientifique CNRS, UMR5163, Laboratoire Adaptation et Pathogenie des Microorganismes, F 38041 Grenoble, France
    J Exp Med 210:2071-86. 2013
    b>Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular protozoan parasite that resides inside a parasitophorous vacuole...
  40. pmc GABAergic signaling is linked to a hypermigratory phenotype in dendritic cells infected by Toxoplasma gondii
    Jonas M Fuks
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    PLoS Pathog 8:e1003051. 2012
    During acute infection in human and animal hosts, the obligate intracellular protozoan Toxoplasma gondii infects a variety of cell types, including leukocytes...
  41. doi Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide
    Michelle L Tonkin
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada
    Science 333:463-7. 2011
    Apicomplexan parasites such as Toxoplasma gondii and Plasmodium species actively invade host cells through a moving junction (MJ) complex assembled at the parasite-host cell interface...
  42. pmc ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18
    Masahiro Yamamoto
    Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Exp Med 208:1533-46. 2011
    ..been identified as a key virulence determinant conferring a high mortality phenotype characteristic of type I Toxoplasma gondii strains...
  43. pmc UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii
    Reed Pifer
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9093, USA
    J Biol Chem 286:3307-14. 2011
    ..Here we show that TLR11, an innate sensor for the Toxoplasma protein profilin, is an intracellular receptor that resides in the endoplasmic reticulum...
  44. pmc Incidence of adult brain cancers is higher in countries where the protozoan parasite Toxoplasma gondii is common
    Frederic Thomas
    IRD, MIVEGEC UMR CNRS IRD UM1, Montpellier, France
    Biol Lett 8:101-3. 2012
    We explored associations between the common protozoan parasite Toxoplasma gondii and brain cancers in human populations. We predicted that T...
  45. doi The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii
    Jonathan C Howard
    Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany
    Curr Opin Microbiol 14:414-21. 2011
    ..IRG proteins (immunity-related GTPases) provide an early defense mechanism in mice against the protozoal pathogen, Toxoplasma gondii...
  46. pmc The C-terminus of Toxoplasma RON2 provides the crucial link between AMA1 and the host-associated invasion complex
    Jessica S Tyler
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Pathog 7:e1001282. 2011
    ..The Toxoplasma MJ is a secreted complex including TgAMA1, a transmembrane protein on the parasite surface, and a complex of ..
  47. pmc Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection
    Allison L Bierly
    Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA
    J Immunol 181:8485-91. 2008
    ..pDC markers Gr-1, B220, and PDCA-1 is preferentially parasitized after infection with the virulent RH strain of Toxoplasma gondii...
  48. doi Modelling parasite dissemination: host cell subversion and immune evasion by Toxoplasma gondii
    Henrik Lambert
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Cell Microbiol 12:292-300. 2010
    ..Here, we review current knowledge on strategies utilized by the apicomplexan parasite Toxoplasma gondii to disseminate and establish infection in its host...
  49. pmc P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages
    Michael P Lees
    Institute for the Biotechnology of Infectious Diseases, University of Technology, Sydney, Broadway, NSW, Australia
    J Immunol 184:7040-6. 2010
    ..1487A>C) loss-of-function P2X7R single nucleotide polymorphism are less effective in killing intracellular Toxoplasma gondii after exposure to ATP compared with macrophages from people with the 1513A wild-type allele...
  50. doi Specificity of the Toxoplasma gondii-altered behaviour to definitive versus non-definitive host predation risk
    P H L Lamberton
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, UK
    Parasitology 135:1143-50. 2008
    The hypothesis that the parasite Toxoplasma gondii manipulates the behaviour of its intermediate rat host in order to increase its chance of being predated specifically by its feline definitive host, rather than a non-definitive host ..
  51. pmc The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites
    Mauld Lamarque
    UMR 5235 CNRS, Université de Montpellier 2, Montpellier, France
    PLoS Pathog 7:e1001276. 2011
    ..Our studies were performed both in Toxoplasma gondii and Plasmodium falciparum and although AMA1 and RON2 proteins have diverged between Apicomplexa species, ..
  52. pmc Toxoplasma gondii and schizophrenia
    E Fuller Torrey
    Stanley Medical Research Institute, Bethesda, Maryland 20814 2142, USA
    Emerg Infect Dis 9:1375-80. 2003
    ..In animals, infections with Toxoplasma gondii can alter behavior and neurotransmitter function. In humans, acute infection with T...
  53. ncbi Recent expansion of Toxoplasma through enhanced oral transmission
    C Su
    Department of Molecular Microbiology, Washington University, St Louis, MO 63110, USA
    Science 299:414-6. 2003
    The global predominance of three clonal Toxoplasma gondii lineages suggests that they are endowed with an exceptional trait responsible for their current parasitism of nearly all warm-blooded vertebrates...
  54. pmc Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma
    Sebastian Lourido
    Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 465:359-62. 2010
    ..Here we show that the Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) is an essential regulator of calcium-dependent exocytosis in ..
  55. pmc T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii
    Michael H Shaw
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Nat Immunol 10:1267-74. 2009
    ..Here we found that Nod2(-/-) mice had less clearance of Toxoplasma gondii and lower interferon-gamma (IFN-gamma) production...
  56. pmc Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases
    Sascha Martens
    Institute for Genetics, University of Cologne, Cologne, Germany
    PLoS Pathog 1:e24. 2005
    ..p47 GTPases are essential for interferon-gamma-induced cell-autonomous immunity against the protozoan parasite, Toxoplasma gondii, in mice, but the mechanism of resistance is poorly understood...
  57. ncbi Kiss and spit: the dual roles of Toxoplasma rhoptries
    John C Boothroyd
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305 5124, USA
    Nat Rev Microbiol 6:79-88. 2008
    b>Toxoplasma gondii is a single-celled, eukaryotic parasite that can only reproduce inside a host cell. Upon entry, this Apicomplexan parasite co-opts host functions for its own purposes...
  58. pmc Structures of Toxoplasma gondii tachyzoites, bradyzoites, and sporozoites and biology and development of tissue cysts
    J P Dubey
    Parasite Biology and Epidemiology Laboratory, USDA Agricultural Research Service, Beltsville, Maryland 20705 2350, USA
    Clin Microbiol Rev 11:267-99. 1998
    Infections by the protozoan parasite Toxoplasma gondii are widely prevalent world-wide in animals and humans...
  59. ncbi A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii
    S Taylor
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63130, USA
    Science 314:1776-80. 2006
    b>Toxoplasma gondii strains differ dramatically in virulence despite being genetically very similar...
  60. pmc Toxoplasmosis: A history of clinical observations
    Louis M Weiss
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Parasitol 39:895-901. 2009
    It has been 100 years since Toxoplasma gondii was initially described in Tunis by Nicolle and Manceaux (1908) in the tissues of the gundi (Ctenodoactylus gundi) and in Brazil by Splendore (1908) in the tissues of a rabbit...
  61. pmc Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases
    Michael S Behnke
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 108:9631-6. 2011
    The population structure of Toxoplasma gondii includes three highly prevalent clonal lineages referred to as types I, II, and III, which differ greatly in virulence in the mouse model...
  62. pmc Characterization of a novel organelle in Toxoplasma gondii with similar composition and function to the plant vacuole
    Kildare Miranda
    Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    Mol Microbiol 76:1358-75. 2010
    b>Toxoplasma gondii belongs to the phylum Apicomplexa and is an important cause of congenital disease and infection in immunocompromised patients. Like most apicomplexans, T...
  63. pmc Transepithelial migration of Toxoplasma gondii is linked to parasite motility and virulence
    Antonio Barragan
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 195:1625-33. 2002
    After oral ingestion, Toxoplasma gondii crosses the intestinal epithelium, disseminates into the deep tissues, and traverses biological barriers such as the placenta and the blood-brain barrier to reach sites where it causes severe ..
  64. ncbi In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha
    R T Gazzinelli
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 157:798-805. 1996
    To examine the function of IL-10 synthesis during early infection with the intracellular protozoan Toxoplasma gondii, IL-10 knockout (KO) mice were inoculated with an avirulent parasite strain (ME-49)...
  65. ncbi Toxoplasma gondii infection in the United States: seroprevalence and risk factors
    J L Jones
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341 3724, USA
    Am J Epidemiol 154:357-65. 2001
    Infection with Toxoplasma gondii can cause severe illness when the organism is contracted congenitally or when it is reactivated in immune-suppressed persons. To determine the prevalence of T...
  66. pmc Bradyzoite-specific surface antigen SRS9 plays a role in maintaining Toxoplasma gondii persistence in the brain and in host control of parasite replication in the intestine
    Seon Kyeong Kim
    Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA
    Infect Immun 75:1626-34. 2007
    b>Toxoplasma gondii is a ubiquitous parasite that persists for the life of a healthy mammalian host. A latent, chronic infection can reactivate upon immunosuppression and cause life-threatening diseases, such as encephalitis...
  67. pmc Seroprevalence of Toxoplasma gondii infection in pet dogs in Lanzhou, Northwest China
    Song Ming Wu
    State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, CAAS, Lanzhou, Gansu Province, PR China
    Parasit Vectors 4:64. 2011
    In recent years, surveys of Toxoplasma gondii infection in dogs have been reported worldwide, including China. However, little is known about the prevalence of T. gondii in pet dogs in Northwest China...
  68. pmc Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein
    Emily E Rosowski
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Exp Med 208:195-212. 2011
    NF-κB is an integral component of the immune response to Toxoplasma gondii. Although evidence exists that T. gondii can directly modulate the NF-κB pathway, the parasite-derived effectors involved are unknown...
  69. pmc Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responses
    Lucia Peixoto
    Department of Biology and Penn Genome Frontiers Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Host Microbe 8:208-18. 2010
    ..modulation of host cell signaling pathways, we exploited a phylogenomic approach to characterize the Toxoplasma gondii kinome, defining a 44 member family of coccidian-specific secreted kinases, some of which have been ..
  70. pmc Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole
    Aliaksandr Khaminets
    Institute for Genetics, University of Cologne, Zulpicher Strasse, Cologne 50674, Germany
    Cell Microbiol 12:939-61. 2010
    ..GTPases (IRGs) constitute an interferon-induced intracellular resistance mechanism in mice against Toxoplasma gondii...
  71. doi Functional dissection of the apicomplexan glideosome molecular architecture
    Karine Frénal
    Department of Microbiology and Molecular Medicine, Centre Medical Universitaire, University of Geneva, CH 1211 Geneva 4, Switzerland
    Cell Host Microbe 8:343-57. 2010
    ....
  72. pmc Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii
    Wendy T Watford
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 205:2803-12. 2008
    ..Accordingly, Tpl2(-/-) mice had impaired host defense against Toxoplasma gondii with reduced parasite clearance and decreased IFN-gamma production...
  73. ncbi Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondii
    Peter J Bradley
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 280:34245-58. 2005
    ..have developed a method for highly efficient purification of rhoptries from one of the best studied Apicomplexa, Toxoplasma gondii, and we carried out a detailed proteomic analysis using mass spectrometry that has identified 38 novel ..
  74. pmc Oral oocyst-induced mouse model of toxoplasmosis: effect of infection with Toxoplasma gondii strains of different genotypes, dose, and mouse strains (transgenic, out-bred, in-bred) on pathogenesis and mortality
    J P Dubey
    United States Department of Agriculture, Animal Natural Resources Institute, Animal Parasitic Disease Laboratory, BARC East, Beltsville, MD 20705 2350, USA
    Parasitology 139:1-13. 2012
    Humans and other hosts acquire Toxoplasma gondii infection by ingesting tissue cysts in undercooked meat, or by food or drink contaminated with oocysts...
  75. pmc Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence
    Michael L Reese
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 108:9625-30. 2011
    b>Toxoplasma gondii, an obligate intracellular parasite of the phylum Apicomplexa, has the unusual ability to infect virtually any warm-blooded animal...
  76. doi Parasite-augmented mate choice and reduction in innate fear in rats infected by Toxoplasma gondii
    Ajai Vyas
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore
    J Exp Biol 216:120-6. 2013
    ..Yet Toxoplasma gondii, a sexually transmitted parasite, gets around this obstacle by manipulating mate choice of uninfected ..
  77. pmc Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii
    Ildiko R Dunay
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 29:306-17. 2008
    The enteric pathogen Toxoplasma gondii is controlled by a vigorous innate T helper 1 (Th1) cell response in the murine model...
  78. pmc Toxoplasma gondii effectors are master regulators of the inflammatory response
    Mariane B Melo
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Trends Parasitol 27:487-95. 2011
    b>Toxoplasma is a highly successful parasite that establishes a life-long chronic infection. To do this, it must carefully regulate immune activation and host cell effector mechanisms...
  79. pmc Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells
    Bjorn F C Kafsack
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Science 323:530-3. 2009
    ..Here, we describe Toxoplasma perforin-like protein 1 (TgPLP1), a secreted perforin-like protein of the intracellular protozoan pathogen ..
  80. pmc Effector cells of both nonhemopoietic and hemopoietic origin are required for interferon (IFN)-gamma- and tumor necrosis factor (TNF)-alpha-dependent host resistance to the intracellular pathogen, Toxoplasma gondii
    G S Yap
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 189:1083-92. 1999
    ..between wild-type and IFN-gamma receptor-deficient mice and their survival assessed following infection with Toxoplasma gondii, a protozoan parasite that invades both hemopoietic and nonhemopoietic cell lineages...
  81. doi The moving junction of apicomplexan parasites: a key structure for invasion
    Sebastien Besteiro
    UMR 5235 CNRS, DIMNP, Université de Montpellier 2, cc 107, 34095 Montpellier Cedex 05, France
    Cell Microbiol 13:797-805. 2011
    ..Based on recent data obtained in Plasmodium and Toxoplasma, an emerging model emphasizes a cooperative role of secreted parasitic proteins in building the MJ and driving ..
  82. pmc The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens
    Oliver Liesenfeld
    Institute of Microbiology and Hygiene, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 6:e20568. 2011
    ..Irgm1(LRG-47), Irgm3(IGTP), and Irgd(IRG-47) has revealed a critical role in microbial clearance, especially for Toxoplasma gondii. The in vivo role of another member of this family, Irga6 (IIGP, IIGP1) has been studied in less detail...
  83. pmc Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6
    Yi Ching Ong
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 285:28731-40. 2010
    The obligate intracellular parasite, Toxoplasma gondii, modulates host immunity in a variety of highly specific ways...
  84. ncbi Cutting edge: dendritic cells are essential for in vivo IL-12 production and development of resistance against Toxoplasma gondii infection in mice
    Cheng hu Liu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 177:31-5. 2006
    A powerful IFN-gamma response is triggered upon infection with the protozoan parasite, Toxoplasma gondii...
  85. ncbi A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis
    Emma H Wilson
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6008, USA
    J Neuroimmunol 165:63-74. 2005
    IL-10 plays a vital role in controlling the inflammatory response during acute Toxoplasma gondii infection, however the production of IL-10 during the chronic phase of toxoplasmosis has been associated with parasite persistence...
  86. pmc Prevalence of Toxoplasma gondii infection in Myocastor coypus in a protected Italian wetland
    Simona Nardoni
    Dipartimento di Patologia Animale, Profilassi ed Igiene degli Alimenti, Viale delle Piagge 2, 56100 Pisa, Italy
    Parasit Vectors 4:240. 2011
    b>Toxoplasma gondii is the causative agent for a major zoonosis with cosmopolitan distribution. Water has been implicated in outbreaks of toxoplasmosis in recent years...
  87. pmc Toxoplasma gondii and other risk factors for schizophrenia: an update
    E Fuller Torrey
    The Stanley Medical Research Institute, 8401 Connecticut Avenue, Suite 200, Chevy Chase, MD 20815, USA
    Schizophr Bull 38:642-7. 2012
    ..In a previous study, antibodies to Toxoplasma gondii were found to be elevated in 23 studies of schizophrenia (OR 2.73; 95% CI 2.10-3.60)...
  88. pmc The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response
    Wendy Niedelman
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    PLoS Pathog 8:e1002784. 2012
    The obligate intracellular parasite Toxoplasma gondii secretes effector proteins into the host cell that manipulate the immune response allowing it to establish a chronic infection...
  89. doi Neuropsychiatric disease and Toxoplasma gondii infection
    S A Henriquez
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow, UK
    Neuroimmunomodulation 16:122-33. 2009
    b>Toxoplasma gondii infects approximately 30% of the world's population, but causes overt clinical symptoms in only a small proportion of people...
  90. doi The immunobiology of the innate response to Toxoplasma gondii
    Catherine M Miller
    Institute for the Biotechnology of Infectious Diseases, University of Technology, Sydney, PO Box 123, Broadway, NSW 2007, Australia
    Int J Parasitol 39:23-39. 2009
    b>Toxoplasma gondii is a unique intracellular parasite. It can infect a variety of cells in virtually all warm-blooded animals...
  91. pmc Autophagy protein Atg3 is essential for maintaining mitochondrial integrity and for normal intracellular development of Toxoplasma gondii tachyzoites
    Sebastien Besteiro
    UMR 5235 CNRS, Universités de Montpellier 2 et 1, Dynamique des Interactions Membranaires Normales et Pathologiques, Montpellier, France
    PLoS Pathog 7:e1002416. 2011
    ..To investigate this in Toxoplasma gondii, we have used TgAtg8 as an autophagosome marker and showed that autophagy and the associated cellular ..
  92. pmc Differential infectivity and division of Toxoplasma gondii in human peripheral blood leukocytes
    J Y Channon
    Departments of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Infect Immun 68:4822-6. 2000
    ..Although tachyzoites were able to divide in each of these cell types, monocytes and dendritic cells were more permissive to rapid tachyzoite division than neutrophils or lymphocytes...
  93. pmc Intracellular transport of Toxoplasma gondii through the blood-brain barrier
    Sabrina M Lachenmaier
    Institute of Microbiology and Hygiene, Charite Medical School Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Neuroimmunol 232:119-30. 2011
    b>Toxoplasma gondii establishes latent infection in the central nervous system of immunocompentent hosts. Toxoplasmic encephalitis is a life threatening reactivation of latent infection in the brain of immunocompromised patients...
  94. pmc Analysis of behavior and trafficking of dendritic cells within the brain during toxoplasmic encephalitis
    Beena John
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 7:e1002246. 2011
    ....
  95. doi Long-term survival of Toxoplasma gondii sporulated oocysts in seawater
    David S Lindsay
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, 1410 Prices Fork Road, Blacksburg, Virginia 24061, USA
    J Parasitol 95:1019-20. 2009
    b>Toxoplasma gondii is now recognized as an important pathogen in costal marine mammals. Oocysts from cat feces are believed to be washed into seawater and serve as a source of infection via transport hosts...
  96. doi Toxoplasma and schizophrenia
    R H Yolken
    Stanley Division of Developmental Neurovirology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 4933, USA
    Parasite Immunol 31:706-15. 2009
    Research on infectious agents as a possible cause of schizophrenia has become prominent in the past decade. Toxoplasma gondii has emerged as a prime candidate for a variety of reasons; (i) many studies have reported that individuals with ..
  97. ncbi Toxoplasmosis - a waterborne zoonosis
    J P Dubey
    Animal Parasitic Diseases Laboratory, United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, BARC East, Building 1001, Beltsville, MD 20705 2350, USA
    Vet Parasitol 126:57-72. 2004
    Humans become infected with Toxoplasma gondii mainly by ingesting uncooked meat containing viable tissue cysts or by ingesting food or water contaminated with oocysts from the feces of infected cats...
  98. ncbi Host resistance in the brain against Toxoplasma gondii
    Yasuhiro Suzuki
    Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, California, USA
    J Infect Dis 185:S58-65. 2002
    ..Humoral immunity also participates in controlling Toxoplasma gondii in the brain...
  99. pmc Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii
    Sethu C Nair
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    J Exp Med 208:1547-59. 2011
    ..Surprisingly, fosmidomycin has no effect on most other apicomplexans. Using Toxoplasma gondii, we establish that the pathway is essential in parasites that are highly fosmidomycin resistant...
  100. doi The probable relation between Toxoplasma gondii and Parkinson's disease
    Ozlem Miman
    Afyon Kocatepe University, Faculty of Medicine, Department of Microbiology, Izmir Street, 5 km, Afyonkarahisar, Turkey
    Neurosci Lett 475:129-31. 2010
    ..Therefore, in this study, we aimed to investigate the possible association between Toxoplasma infection and PD by evaluating the serum anti-Toxoplasma gondii IgG antibodies...
  101. doi Apicomplexan cytoskeleton and motors: key regulators in morphogenesis, cell division, transport and motility
    Joana M Santos
    Department of Microbiology and Molecular Medicine, Faculty of Medicine University of Geneva CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Int J Parasitol 39:153-62. 2009
    ..The present review aims to summarize the most recent findings in the field...

Research Grants75

  1. Integrated Microfluidic Platform for Point-of-Care Serodiagnostics
    Xiaowu Liang; Fiscal Year: 2013
    ..pseudomallei, Coxiella burnetii, Salmonella enterica typhi, Rickettsia rickettsii, Orientia tsutsugamushi, Toxoplasma gondii, M. tuberculosis, variola major related pox viruses, Dengue, and West Nile)...
  2. MECHANISM-BASED DRUG SELECTION AND DESIGN: NUCLEOTIDE SA
    Buddy Ullman; Fiscal Year: 2003
    ..and structural studies on key transporters and enzymes of the pyrimidine and purine salvage pathways in Toxoplasma gondii and related apicomplexan parasites, including Cryptosporidium, Sarcocystis, and Plasmodium...
  3. A Systems Biology Approach to the Model Apicomplexan Toxoplasma gondii
    William J Sullivan Jr; Fiscal Year: 2010
    ..These obligate intracellular parasites include Toxoplasma gondii, Plasmodium species and Cryptosporidium...
  4. Development of an Inhibitor of Toxoplasma gondii
    Richard D Wood; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Toxoplasma (T...
  5. International Workshop on Opportunistic Protists (IWOP-12, 13 and 14)
    Louis M Weiss; Fiscal Year: 2012
    ..The IWOP meetings now include research presentations on Cryptosporidia;Microsporidia;Toxoplasma gondii;and free-living amebae that are pathogenic...
  6. Pathogen-Specific Regulation of Protein Assembly
    ALLEN BERNARD REITZ; Fiscal Year: 2010
    ..enterocolitica to Plasmodium falciparum, Pseudomonas aeruginosa, Vibrio cholerae, and Toxoplasma gondii...
  7. Role of chemokines in the T cell response to ocular toxoplasmosis
    Christopher A Hunter; Fiscal Year: 2012
    ..An ongoing T cell-mediated immune response is necessary to limit Toxoplasma gondii replication and destruction of the retina...
  8. Novel Model Systems Link Floridean Starch Metabolism to Lafora Disease
    Matthew S Gentry; Fiscal Year: 2010
    ..I recently identified laforin orthologs in five unicellular eukaryotes, including Cyanidioschyzon merolae and Toxoplasma gondii...
  9. Infectious Disease Genomics and Bioinformatics Training in Brazil
    Jessica C Kissinger; Fiscal Year: 2013
    ..These organisms include: Plasmodium sp., Trypanosoma cruzi. Toxoplasma gondii, Schistosoma mansoni. Anopheles, Blomphalaria and Humans...
  10. Toxoplasma Epigenomics and Gene Expression
    Kami Kim; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The obligate intracellular parasite Toxoplasma gondii is a major opportunistic pathogen of the AIDS epidemic...
  11. Translational control and latent Toxoplasma infection
    RONALD C contact WEK; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Toxoplasma gondii is an intracellular protozoan parasite that causes congenital birth defects, as well as life-threatening opportunistic disease in the immunocompromised, such as AIDS patients or ..
  12. MOUSE MODELS FOR UNDERSTANDING HOST RESPONES TO INTRACELLULAR PATHOGENS
    Ellen A Robey; Fiscal Year: 2010
    ..The three projects with many proposed collaborative experiments are: Initiation of immune responses to Toxoplasma gondii (Project 1), The role of "apoptotic proteins" in regulation of innate immunity (Project 2) and Induction ..
  13. Characterization of CCR5-like Molecules in Leishmania
    Lynn Soong; Fiscal Year: 2010
    ..for molecular mimicry of host cytokines/chemokines and their receptors by many pathogens, including DNA viruses, Toxoplasma gondii, and Schistosoma mansoni, such mimicry has not been identified for trypanosomatids...
  14. A Heterologous Expression System for Apicomplexa Genes
    JOSE A FERNANDEZ ROBLEDO; Fiscal Year: 2010
    ..b>Toxoplasma, Cryptosporidium, and Cyclospora are also well known to public health authorities since they pose a threat to ..
  15. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    William J Sullivan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Toxoplasma gondii is a protozoan parasite that poses a significant risk to AIDS patients and is listed by NIAID as a Category B Priority Pathogen for biodefense...
  16. How do you build a parasite?
    John Murray; Fiscal Year: 2009
    DESCRIPTION (provided by the applicant): Toxoplasma gondii is a ubiquitous pathogen infecting an estimated one-third of the U.S...
  17. Targeting Entry Pathways in Leishmaniasis
    DAWN MARIE WETZEL; Fiscal Year: 2013
    ..I am a pediatric infectious diseases fellow who earned a Ph.D. in microbiology studying the parasite Toxoplasma gondii...
  18. Nikon A1RSI Confocal Microscope
    Sailen Barik; Fiscal Year: 2012
    ..cell drug delivery;Chromosome structure and recombination during meiosis;Circadian clock location and function;Toxoplasma-host mitochondria interaction;Regulation of innate immunity by RNA viruses;Differentiation of megakaryocytes and ..
  19. Control of Immune responses by lipoxins during tuberculosis
    Julio Aliberti; Fiscal Year: 2012
    ..Our similar findings in mouse models of Toxoplasma gondii infection allowed for initial mechanistic characterization of LXA4 mediated counter-regulation...
  20. CHARACTERIZATION OF ESSENTIAL RHOPTRY KINASES OF TOXOPLASMA GONDII
    RONALD DREW ETHERIDGE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Toxoplasma gondii is a widespread protozoan parasite that is capable of causing congenital disease in developing infants and severe complications in immunocompromised patients...
  21. Dissecting a novel mechanism of drug-induced death in Toxoplasma gondii
    GUSTAVO A ARRIZABALAGA; Fiscal Year: 2013
    ..the causative agent of malaria, Cryptosporidium, which causes gastrointestinal disease, and the category B agent Toxoplasma gondii, which can be pathogenic in immunocompromised hosts and the developing fetus...
  22. Identifying cellular and molecular interactions along the pathway to symbiosis
    Elizabeth A Vallen; Fiscal Year: 2012
    ..In addition, analyzing the interaction between these organisms will likely give insight into the interaction of other animals (like humans) with intracellular eukaryotic parasites like Toxoplasma, Plasmodium and Cryptosporidium.
  23. The role of Fas-associated death domain in necroptosis in vivo
    Astar Winoto; Fiscal Year: 2013
    ..To examine the possible enhanced immunity of dcFADD-/- mice, they will be challenged with influenza and Toxoplasma gondii and studied in details...
  24. Glycoregulation of Skp1 in the cytoplasm and nucleus
    Christopher M West; Fiscal Year: 2012
    ..aim 4 will carry out tests for the evolutionary conservation of Skp1 glycoregulation in the apicomplexan Toxoplasma gondii, the agent for human toxoplasmosis...
  25. TARGETING ESSENTIAL ROP KINASES IN TOXOPLASMA
    L David Sibley; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Toxoplasma gondii is a widespread protozoan parasite of wild, domestic, and companion animals that also commonly infects humans...
  26. Targeting host deubiquitinases for broad spectrum anti-infective therapy
    Christiane Wobus; Fiscal Year: 2013
    ..and human norovirus, encephalomyocarditis virus, Sindbis virus, La Crosse virus);and an apicomplexan parasite (Toxoplasma gondii)...
  27. Genetic dissection of parasite metabolism
    Boris Striepen; Fiscal Year: 2013
    ..proposal outlines a comprehensive plan to genetically dissect the fatty acid metabolism of the human pathogen Toxoplasma gondii. T. gondii infection is widespread in the U.S...
  28. Visualizing impacts of T. gondii invasion events on mucosal immunity
    DAVID ALLAN CHRISTIAN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Infection with Toxoplasma gondii, even in immune competent patients, can cause severe morbidity, congenital disease, and even death...
  29. The plant-like vacuole of Toxoplasma gondii
    Silvia N Moreno; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Toxoplasma gondii belongs to the phylum Apicomplexa and is an important cause of congenital disease and infection in immunocompromised patients...
  30. Antitoxoplasmosis Drug Design and Optimization
    MICHAEL KEVIN RISCOE; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Toxoplasma gondii is the causative agent of toxoplasmosis...
  31. Genetic dissection of parasite metabolism
    Boris Striepen; Fiscal Year: 2009
    ..This proposal outlines a comprehensive plan to genetically dissect the fatty acid metabolism of the human pathogen Toxoplasma gondii. T. gondii infection is widespread in the U.S...
  32. Efficient Linkage Mapping Methods for Schistosoma mansoni
    Philip T LoVerde; Fiscal Year: 2013
    ..has proved to be an extremely powerful approach for identification of functional genes in protozoan parasites (Toxoplasma, Plasmodium, Trypanosomes), allowing identification of genes underlying important biomedical traits such as host ..
  33. The AP2 factors required for Toxoplasma replication
    Michael W White; Fiscal Year: 2013
    ..new daughter parasites requires tight control over the delivery of protein products, and in Plasmodium and Toxoplasma a cascade of >2800 mRNAs serially unfolds during each division cycle...
  34. Pore Formation by Cholesterol Dependent Cytolysins
    Rodney K Tweten; Fiscal Year: 2013
    ..membrane attack complex), development (astrotactins), diseases caused by eukaryotic pathogens such as Toxoplasma and malaria, and tumor destruction (perforin)...
  35. Identifying components of Toxoplasma oocysts that confer environmental resistance
    HEATHER MICHELLE FRITZ; Fiscal Year: 2013
    DESCRIPTION (provided by applicant: Toxoplasma gondii is an obligate intracellular parasite in the family Apicomplexa that infects a broad range of warm-blooded animals, including humans...
  36. Essential Cell Cycle Mechanisms in Toxoplasma
    Michael W White; Fiscal Year: 2013
    Increased parasite burden is a key factor in the severity of clinical toxoplasmosis and thus, pathogenesis in Toxoplasma gondii infections is caused primarily by the growth of the parasite...
  37. A novel vacuolar compartment in Toxoplasma gondii
    Silvia N Moreno; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Our goal is to find ways of interfering with Toxoplasma gondii metabolic pathways as a strategy for controlling infections caused by this and similar parasites...
  38. Regulation of Host Defense by IRG Proteins
    Gregory A Taylor; Fiscal Year: 2013
    ..play critical roles in resistance to intracellular bacteria and protozoa, including Salmonella typhimurium and Toxoplasma gondii...
  39. Calcium Dependent Protein Kinase 1 as a drug target for T. gondii and C. parvum
    ARTHUR CLINTON WHITE; Fiscal Year: 2013
    ..provided by applicant): New therapeutics are needed for infections caused by Cryptosporidium parvum and Toxoplasma gondii. Calcium dependent protein kinase 1 (CDPK1) of T...
  40. Host cell manipulation by Toxoplasma
    Isabelle Coppens; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The obligate intracellular protozoan Toxoplasma gondii is the etiological agent of toxoplasmic encephalitis that remains a major cause of death in AIDS patients...
  41. Pathogenic and Protective T Cells in Toxoplasmosis
    George S Yap; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A successful cellular immune response to Toxoplasma gondii and many other intracellular pathogens involves a delicate balance between the actions of IL-12, a pro- inflammatory innate cytokine ..
  42. Low Activity Oligomers of Porphobilinogen Synthase as Antibiotic Targets
    Eileen K Jaffe; Fiscal Year: 2010
    ..quaternary structure assemblies of PBGS from the human pathogens Pseudomonas aeruginosa, Vibrio cholera, Toxoplasma gondii, and Plasmodium falciparum. Post-docking criteria will be used to select compounds for purchase...
  43. Parasite / host interaction and the neurobiology of fear
    Robert M Sapolsky; Fiscal Year: 2012
    ..The protozoan parasite Toxoplasma gondii fits this description well...
  44. MYST opportunities for Toxoplasma drug development
    William J Sullivan Jr; Fiscal Year: 2010
    ..the most notorious protozoan parasites, such as Plasmodium (malaria), Cryptosporidium (diarrheal disease), and Toxoplasma (toxoplasmic encephalitis)...
  45. Genetic models for post-genome functional analysis of Toxoplasma gondii
    David J Bzik; Fiscal Year: 2010
    b>Toxoplasma gondii is an important opportunistic infection of AIDS patients. Improved strategies and approaches are urgently needed to more effectively prevent and treat recurrent opportunistic infections in AIDS...
  46. Host cell influences on the development of toxoplasmic encephalitis
    Anita Koshy; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): PROJECT SUMMARY: Toxoplasma gondii is an intracellular parasite that has a particular tropism for the central nervous system (CNS) where it establishes a latent, encysted infection...
  47. Molecular mechanisms of pathogenesis in Toxoplasma
    Jon P Boyle; Fiscal Year: 2010
    ..by applicant): My long-term research goal is to study the mechanisms of virulence in the intracellular pathogen Toxoplasma gondii, and determine the role of parasite strain type in determining disease outcome. T...
  48. Biology of the Apicomplexan Plastid
    Boris Striepen; Fiscal Year: 2013
    ..Using Toxoplasma as a model organism we will conduct genetic, cell biological and biochemical approaches to characterize the ..
  49. Stress responses in the AIDS opportunistic parasite Toxoplasma gondii
    BRAD JOYCE; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Toxoplasma gondii is an intracellular protozoan parasite that represents a major threat to immunocompromised individuals, including AIDS patients, newborns with a congenital infection, and organ ..
  50. Role of intraepithelial T cells in Toxoplasma gondii-induced inflammatory ileitis
    Eric Y Denkers; Fiscal Year: 2010
    ..causes of intestinal inflammatory pathology induced during infection with the opportunistic protozoan pathogen Toxoplasma gondii...
  51. A Novel MAPK family in T. gondii
    Tyler J Curiel; Fiscal Year: 2010
    ..2 Test the hypothesis that blocking MAPK1-Tg activation is a mechanism of therapeutic action of p38 MAPK inhibitors. 3 Test the hypothesis that blocking MAPK1-Tg augments efficacy of anti-Toxoplasma therapies in vivo.
  52. Small Molecule Approaches to Studying T. gondii Invasion
    Gary E Ward; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Toxoplasma gondii is a widespread apicomplexan parasite that causes severe disease in the congenitally-infected fetus and in immunocompromised persons. T...
  53. Toxoplasma strain-specific modulation of mouse immune cells
    JEROEN SAEIJ; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Toxoplasma is an obligate intracellular parasite that can cause serious disease in immunocompromised patients and in the developing fetus...
  54. Novel rhoptry effector proteins in Toxoplasma host-pathogen interaction
    PETER JOHN BRADLEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Toxoplasma gondii is an obligate intracellular parasite that causes severe central nervous system disorders in immunocompromised individuals and birth defects in congenitally infected neonates...
  55. Optimizing Inhibitors of T. gondii ENR
    Rima L McLeod; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Toxoplasma gondii infections cause suffering and mortality in those congenitally infected or immune compromised...
  56. Midcareer Investigator Award in Patient-Oriented NeuroAIDS Research
    Scott L Letendre; Fiscal Year: 2013
    ..nervous system of latent or minimally symptomatic infections with pathogens such as Plasmodium, Cytomegalovirus, Toxoplasma, and hepatitis C virus. This work will particularly focus on Dr...
  57. Signal transduction during Toxoplasma infection
    Eric Y Denkers; Fiscal Year: 2012
    ..of this application is to understand the molecular pathogenesis of infection with the intracellular protozoan Toxoplasma gondii...
  58. Targeting Host and Apicomplexan Isoprenoid Pathways
    Silvia N Moreno; Fiscal Year: 2013
    ..b>Toxoplasma gondii is the causative agent of human toxoplasmosis, a systemic infection acquired mostly through contaminated ..
  59. Organization of Toxoplasma invasion and cell division by EF-hand proteins
    Marc Jan Gubbels; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The apicomplexan parasite Toxoplasma gondii is the causative agent of life-threatening encephalitis in immunocompromised patients and in addition can cause a variety of birth defects if the infection ..
  60. The Role of CD73 in toxoplasma gondii pathogenesis.
    Deeqa A Mahamed; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Toxoplasma gondii is an obligate intracellular protozoan pathogen with broad host range and tissue trophism. Unlike vertebrate cells, which are capable of de novo adenosine synthesis, T...
  61. A novel approach to characterize the Toxoplasma gondii secretome in vivo
    Jon P Boyle; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Toxoplasma gondii is an important human pathogen that has infected over 50 million people in the U.S., and over a billion people worldwide...
  62. Novel nucleosome composition and modifications in protozoal parasite Toxoplasma g
    Sergio Oscar Angel; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The protozoan parasite Toxoplasma gondii is an important human and veterinary pathogen...
  63. Mechanisms of Dinitroaniline Action, Selectivity and Resistance
    Naomi S Morrissette; Fiscal Year: 2010
    ..Leishmania spp., Entamoeba spp.,Plasmodium falcipamm, Cryptosporidium parvum and Toxoplasma gondii)...
  64. 7th International Congress on Toxoplasmosis
    Kami Kim; Fiscal Year: 2003
    ..The Toxoplasma meeting is an international meeting that has occurred every other year since 1990 and lasts four to five days...
  65. Parasite/Host Interactions and the Neurobiology of Fear
    Robert Sapolsky; Fiscal Year: 2006
    ..This proposal concerns an example relevant to understanding fear and anxiety. The protozoan Toxoplasma gondii reproduces sexually in a two-species life cycle. The parasite reproduces in cats, and is then excreted...
  66. MECHANISM BASED DRUG SELECTION AND DESIGN FOR T GONDII
    Keith Joiner; Fiscal Year: 1999
    b>Toxoplasma gondii is the leading cause of focal central nervous system infections in patients with the acquired immunodeficiency syndrome (AIDS). The limited repertoire of therapeutic agents for T...
  67. CRYSTAL STRUCTURE OF TOXOPLASMA GONDII HGPRT
    DAVID BORHANI; Fiscal Year: 1999
    DESCRIPTION: (Adapted from Applicant's Abstract). Toxoplasma gondii, a pervasive parasitic protozoan, causes significant morbidity and mortality among patients with Acquired Immune Deficiency Syndrome (AIDS), as well as among organ ..
  68. 7th International Workshops on Opportunistic Protists
    EDNA KANESHIRO; Fiscal Year: 2001
    ..of these workshops will be on the AIDS-related opportunistic infectious protists, Pneumocystis, Cryptosporidium, Toxoplasma and the microsporidia and amoebae...
  69. The Role of NKG2D/DAP10 in Toxoplasma gondii Infection
    RACHEL MARGARET PRESTI; Fiscal Year: 2010
    ..The Apicomplexa consist of numerous protozoa which cause disease, including Plasmodium, Toxoplasma, Cryptosporidia, and Babesia...
  70. Mucosal Immunity to Toxoplasma gondii
    L Sibley; Fiscal Year: 2007
    ..Infection with the parasite Toxoplasma gondii occurs by an oral route following ingestion of oocysts contaminating the environment or of tissue cysts ..
  71. Antibodies and Congenital Neospora Caninum Transmission
    GARY HALDORSON; Fiscal Year: 2004
    ..This apicomplexan parasite is similar to Toxoplasma gondii and Plasmodium sp., both of which cause abortions and congenital infections in humans...
  72. Toxoplasma Gondii Regulation of Host Gene Expression
    Ira Blader; Fiscal Year: 2004
    b>Toxoplasma gondii is an intracellular apicomplexan parasite that can infect almost any nucleated vertebrate cell. Toxoplasmosis, the disease caused by T...
  73. The isoprenoid pathway from Toxoplasma gondii
    Silvia Moreno; Fiscal Year: 2007
    ..Little is known about the isoprenoid pathway in Toxoplasma gondii...
  74. SURFACE PROTEINS OF TOXOPLASMA GONDII
    Gary Ward; Fiscal Year: 2002
    The protozoan parasite Toxoplasma gondii is an important human pathogen. As many as 4000 children are born each year in the USA with congenital toxoplasmosis, the symptoms of which range from impaired vision to hydrocephalus and death. T...
  75. ALTERED LEUKOTRIENE RELEASE IN PARASITIZED PHAGOCYTES
    William Henderson; Fiscal Year: 1990
    An important question in biology is how intracellular parasites infect phagocytic cells. Toxoplasma gondii is an obligate intracellular protozoal parasite that actively invades macrophages without triggering respiratory burst activity, ..