apicomplexa

Summary

Summary: A phylum of protozoa characterized by the presence of complex apical organelles generally consisting of a conoid that aids in penetrating host cells, rhoptries that possibly secrete a proteolytic enzyme, and subpellicular microtubules that may be related to motility.

Top Publications

  1. ncbi Repeated secondary loss of adaptin complex genes in the Apicomplexa
    William D Nevin
    Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK
    Parasitol Int 58:86-94. 2009
  2. pmc A common red algal origin of the apicomplexan, dinoflagellate, and heterokont plastids
    Jan Janouskovec
    Department of Botany, University of British Columbia, Vancouver, BC, Canada
    Proc Natl Acad Sci U S A 107:10949-54. 2010
  3. ncbi Metabolic pathways in the apicoplast of apicomplexa
    Frank Seeber
    Robert Koch Institut, Berlin, Germany
    Int Rev Cell Mol Biol 281:161-228. 2010
  4. ncbi Intracellular parasite invasion strategies
    L D Sibley
    Department of Molecular Microbiology, Center for Infectious Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 304:248-53. 2004
  5. ncbi Functional genetics in Apicomplexa: potentials and limits
    Julien Limenitakis
    Department of Microbiology and Molecular Medicine, CMU, University of Geneva, Geneva, Switzerland
    FEBS Lett 585:1579-88. 2011
  6. ncbi Particularities of mitochondrial structure in parasitic protists (Apicomplexa and Kinetoplastida)
    Wanderley de Souza
    Laboratorio de Ultraestrutura Celular Hertha Meyer, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS Bloco G, Ilha do Fundao, 21941 902, Rio de Janeiro RJ, Brazil
    Int J Biochem Cell Biol 41:2069-80. 2009
  7. ncbi Alveolate mitochondrial metabolic evolution: dinoflagellates force reassessment of the role of parasitism as a driver of change in apicomplexans
    Jillian C Danne
    School of Botany, University of Melbourne, Victoria, Australia
    Mol Biol Evol 30:123-39. 2013
  8. pmc Red and problematic green phylogenetic signals among thousands of nuclear genes from the photosynthetic and apicomplexa-related Chromera velia
    Christian Woehle
    Molecular Evolution Botanik III, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Genome Biol Evol 3:1220-30. 2011
  9. pmc The origins of apicomplexan sequence innovation
    James Wasmuth
    Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario M5G 2L3, Canada
    Genome Res 19:1202-13. 2009
  10. ncbi Proteomes and transcriptomes of the Apicomplexa--where's the message?
    J M Wastling
    Department of Pre clinical Veterinary Science, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 7ZJ, UK
    Int J Parasitol 39:135-43. 2009

Research Grants

  1. A Systems Biology Approach to the Model Apicomplexan Toxoplasma gondii
    William J Sullivan Jr; Fiscal Year: 2010
  2. Toxoplasma Epigenomics and Gene Expression
    Kami Kim; Fiscal Year: 2013
  3. A Heterologous Expression System for Apicomplexa Genes
    JOSE A FERNANDEZ ROBLEDO; Fiscal Year: 2010
  4. How do you build a parasite?
    John Murray; Fiscal Year: 2009
  5. Dissecting a novel mechanism of drug-induced death in Toxoplasma gondii
    GUSTAVO A ARRIZABALAGA; Fiscal Year: 2013
  6. The plant-like vacuole of Toxoplasma gondii
    Silvia N Moreno; Fiscal Year: 2013
  7. The AP2 factors required for Toxoplasma replication
    Michael W White; Fiscal Year: 2013
  8. Identifying components of Toxoplasma oocysts that confer environmental resistance
    HEATHER MICHELLE FRITZ; Fiscal Year: 2013
  9. MYST opportunities for Toxoplasma drug development
    William J Sullivan Jr; Fiscal Year: 2010
  10. Biology of the Apicomplexan Plastid
    Boris Striepen; Fiscal Year: 2013

Detail Information

Publications226 found, 100 shown here

  1. ncbi Repeated secondary loss of adaptin complex genes in the Apicomplexa
    William D Nevin
    Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK
    Parasitol Int 58:86-94. 2009
    The Apicomplexa include parasites of devastating medical and economic consequence...
  2. pmc A common red algal origin of the apicomplexan, dinoflagellate, and heterokont plastids
    Jan Janouskovec
    Department of Botany, University of British Columbia, Vancouver, BC, Canada
    Proc Natl Acad Sci U S A 107:10949-54. 2010
    ..g., ciliates, Cryptosporidium, and Phytophthora)...
  3. ncbi Metabolic pathways in the apicoplast of apicomplexa
    Frank Seeber
    Robert Koch Institut, Berlin, Germany
    Int Rev Cell Mol Biol 281:161-228. 2010
    Intracellular parasites of the phylum Apicomplexa harbor a plastid-like organelle called apicoplast that is the most reduced organelle of this type known...
  4. ncbi Intracellular parasite invasion strategies
    L D Sibley
    Department of Molecular Microbiology, Center for Infectious Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 304:248-53. 2004
    ..Efficient invasion has brought widespread success to this group, which includes Toxoplasma, Plasmodium, and Cryptosporidium...
  5. ncbi Functional genetics in Apicomplexa: potentials and limits
    Julien Limenitakis
    Department of Microbiology and Molecular Medicine, CMU, University of Geneva, Geneva, Switzerland
    FEBS Lett 585:1579-88. 2011
    ....
  6. ncbi Particularities of mitochondrial structure in parasitic protists (Apicomplexa and Kinetoplastida)
    Wanderley de Souza
    Laboratorio de Ultraestrutura Celular Hertha Meyer, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS Bloco G, Ilha do Fundao, 21941 902, Rio de Janeiro RJ, Brazil
    Int J Biochem Cell Biol 41:2069-80. 2009
    ..In the phylum Apicomplexa, several species of Plasmodium cause malaria, whereas Toxoplasma gondii is a cosmopolite parasite found on all ..
  7. ncbi Alveolate mitochondrial metabolic evolution: dinoflagellates force reassessment of the role of parasitism as a driver of change in apicomplexans
    Jillian C Danne
    School of Botany, University of Melbourne, Victoria, Australia
    Mol Biol Evol 30:123-39. 2013
    ....
  8. pmc Red and problematic green phylogenetic signals among thousands of nuclear genes from the photosynthetic and apicomplexa-related Chromera velia
    Christian Woehle
    Molecular Evolution Botanik III, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Genome Biol Evol 3:1220-30. 2011
    ....
  9. pmc The origins of apicomplexan sequence innovation
    James Wasmuth
    Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario M5G 2L3, Canada
    Genome Res 19:1202-13. 2009
    The Apicomplexa are a group of phylogenetically related parasitic protists that include Plasmodium, Cryptosporidium, and Toxoplasma. Together they are a major global burden on human health and economics...
  10. ncbi Proteomes and transcriptomes of the Apicomplexa--where's the message?
    J M Wastling
    Department of Pre clinical Veterinary Science, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 7ZJ, UK
    Int J Parasitol 39:135-43. 2009
    The Apicomplexa have some of the most comprehensive and integrated proteome datasets of all pathogenic micro-organisms...
  11. ncbi Mitochondrial translation in absence of local tRNA aminoacylation and methionyl tRNA Met formylation in Apicomplexa
    Paco Pino
    Department of Microbiology and Molecular Medicine, CMU, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Mol Microbiol 76:706-18. 2010
    ..the unexpected absence of tRNA(Met) formyltransferase and peptide deformylase implies that the requirement for a specialized formylmethionyl-tRNA(Met) for translation initiation is bypassed in the mitochondrion of Apicomplexa.
  12. pmc The evolution, metabolism and functions of the apicoplast
    Liting Lim
    School of Botany, University of Melbourne, Parkville, Victoria 3010, Australia
    Philos Trans R Soc Lond B Biol Sci 365:749-63. 2010
    ....
  13. pmc Extrachromosomal DNA in the Apicomplexa
    R J Wilson
    National Institute for Medical Research, London, United Kingdom
    Microbiol Mol Biol Rev 61:1-16. 1997
    ..The malarial mtDNA has a phage-like replication mechanism and undergoes extensive recombination like the mtDNA of some other lower eukaryotes...
  14. pmc Proteases as regulators of pathogenesis: examples from the Apicomplexa
    Hao Li
    Departments of Pathology and Microbiology and Immunology, Stanford University, Standford, CA 94305, USA
    Biochim Biophys Acta 1824:177-85. 2012
    ..This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome...
  15. ncbi Gliding motility and cell invasion by Apicomplexa: insights from the Plasmodium sporozoite
    R Menard
    Laboratoire de Biologie et Genetique du Paludisme, Institut Pasteur, Paris, France
    Cell Microbiol 3:63-73. 2001
    b>Apicomplexa constitute one of the largest phyla of protozoa. Most Apicomplexa, including those pathogenic to humans, are obligate intracellular parasites...
  16. ncbi Hijacking of host cellular functions by the Apicomplexa
    Fabienne Plattner
    Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva CMU, 1211 Geneva 4, Switzerland
    Annu Rev Microbiol 62:471-87. 2008
    ..In recent years, it has become evident that protozoan pathogens, including members of the phylum Apicomplexa, also hijack their host cell's functions to access nutrients and to escape cellular defenses and immune ..
  17. ncbi Phylogeny of marine Gregarines (Apicomplexa)--Pterospora, Lithocystis and Lankesteria--and the origin(s) of coelomic parasitism
    Brian S Leander
    Canadian Institute for Advanced Research, Program in Evolutionary Biology, Departments of Botany and Zoology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Protist 157:45-60. 2006
    ..than it was to the Pterospora clade. These data suggested that coelomic parasitism evolved more than once from different marine intestinal eugregarines, although a larger taxon sample is needed to further explore this inference...
  18. ncbi Role of proteases in host cell invasion by Toxoplasma gondii and other Apicomplexa
    Kami Kim
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Acta Trop 91:69-81. 2004
    ..Recent studies in Toxoplasma gondii and other Apicomplexa have led to the identification of proteases that may mediate these processing events...
  19. ncbi Divergent polyamine metabolism in the Apicomplexa
    Tuesday Cook
    Haskins Laboratories, Pace University, New York, NY 10038, USA
    Microbiology 153:1123-30. 2007
    ..The lack of polyamine biosynthesis by T. gondii is contrasted with polyamine metabolism by other apicomplexans...
  20. ncbi Striated fiber assemblin in apicomplexan parasites
    Karl Ferdinand Lechtreck
    Botanists Institut, Universitat zu Koln, Gyrhofstr 15, D 50931 Cologne, Germany
    Mol Biochem Parasitol 128:95-9. 2003
  21. ncbi The life cycle and host specificity of Psychodiella sergenti n. sp. and Ps. tobbi n. sp. (Protozoa: Apicomplexa) in sand flies Phlebotomus sergenti and Ph. tobbi (Diptera: Psychodidae)
    Lucie Lantová
    Department of Parasitology, Charles University in Prague, Czech Republic
    J Invertebr Pathol 105:182-9. 2010
    ..Both gregarines are considered as serious pathogens in laboratory-reared colonies of Old World sand flies...
  22. ncbi Biosynthetic pathways of plastid-derived organelles as potential drug targets against parasitic apicomplexa
    Frank Seeber
    FB Biologie Parasitologie, Philipps Universitat Marburg, Karl von Frisch Str, D 35032 Marburg, Germany
    Curr Drug Targets Immune Endocr Metabol Disord 3:99-109. 2003
    ..A short overview of the presently available high-throughput methods for Apicomplexa to evaluate the potency of new inhibitory substances will also be given.
  23. ncbi Global protein expression analysis in apicomplexan parasites: current status
    Sabina I Belli
    Institute for the Biotechnology of Infectious Diseases, University of Technology Sydney, Australia
    Proteomics 5:918-24. 2005
    Members of the phylum Apicomplexa are important protozoan parasites that cause some of the most serious, and in some cases, deadly diseases in humans and animals...
  24. pmc Cytoskeleton of apicomplexan parasites
    Naomi S Morrissette
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Microbiol Mol Biol Rev 66:21-38; table of contents. 2002
    The Apicomplexa are a phylum of diverse obligate intracellular parasites including Plasmodium spp...
  25. ncbi Comparative genomic and phylogenetic analyses of calcium ATPases and calcium-regulated proteins in the apicomplexa
    Kisaburo Nagamune
    Department of Molecular Microbiology, Washington University School of Medicine, USA
    Mol Biol Evol 23:1613-27. 2006
    The phylum Apicomplexa comprises a large group of early branching eukaryotes that includes a number of human and animal parasites...
  26. ncbi Rhomboid-like proteins in Apicomplexa: phylogeny and nomenclature
    Timothy J Dowse
    Department of Biological Sciences, Sir Alexander Fleming Building, Imperial College London, UK, SW7 2AZ
    Trends Parasitol 21:254-8. 2005
    ..secreted adhesive proteins within their transmembrane domains, at a site conserved in similar proteins of other Apicomplexa. Current evidence suggests that MPP1 is ubiquitous in the phylum and is encoded by a rhomboid gene...
  27. ncbi Molecular characterization of gregarines from sand flies (Diptera: Psychodidae) and description of Psychodiella n. g. (Apicomplexa: Gregarinida)
    Jan Votypka
    Department of Parasitology, Faculty of Science, Charles University, Prague CZ 128 44, Czech Republic
    J Eukaryot Microbiol 56:583-8. 2009
    ....
  28. ncbi A plastid of probable green algal origin in Apicomplexan parasites
    S Kohler
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 275:1485-9. 1997
    Protozoan parasites of the phylum Apicomplexa contain three genetic elements: the nuclear and mitochondrial genomes characteristic of virtually all eukaryotic cells and a 35-kilobase circular extrachromosomal DNA...
  29. ncbi Diversity of microbial eukaryotes in sediment at a deep-sea methane cold seep: surveys of ribosomal DNA libraries from raw sediment samples and two enrichment cultures
    Kiyotaka Takishita
    Japan Agency for Marine Earth Science and Technology JAMSTEC, Yokosuka, Kanagawa 237 0061, Japan
    Extremophiles 11:563-76. 2007
    ..Among other clones, phylotypes of eukaryotic parasites, such as Apicomplexa, Ichthyosporea, and Phytomyxea, were identified...
  30. ncbi Cryptosporidium parvum appears to lack a plastid genome
    G Zhu
    Wadsworth Center, New York State Department of Health, Albany, NY 12201 2002, USA
    Microbiology 146:315-21. 2000
    Surprisingly, unlike most Apicomplexa, Cryptosporidium parvum appears to lack a plastid genome...
  31. ncbi An ultrastructural comparison of the attachment sites between Gregarina steini and Cryptosporidium muris
    Andrea Valigurová
    Department of Botany and Zoology, Faculty of Science, Masaryk University, Kotlarska 2, 611 37 Brno, Czech Republic
    J Eukaryot Microbiol 54:495-510. 2007
    ..steini trophozoites. In both investigated organisms, the apical complex disappears early during cell invasion. The possibility of the epicellular location of Cryptosporidium on the surface of host cells is discussed...
  32. pmc Efficacy of eleven antimicrobials against a gregarine parasite (Apicomplexa: Protozoa)
    Shajahan Johny
    Department of Biological Sciences, Box 4120, Illinois State University, Normal, Illinois, 61790, USA
    Ann Clin Microbiol Antimicrob 6:15. 2007
    The Apicomplexa are a diverse group of obligate protozoan parasites infesting a wide range of invertebrate and vertebrate hosts including humans...
  33. ncbi Eugregarine trophozoite detachment from the host epithelium via epimerite retraction: fiction or fact?
    Andrea Valigurová
    Department of Botany and Zoology, Faculty of Science, Masaryk University, Kotlarska 2, 611 37 Brno, Czech Republic
    Int J Parasitol 39:1235-42. 2009
    Eugregarines represent a diverse group of Apicomplexa parasitising numerous invertebrates...
  34. ncbi Post-genomics resources and tools for studying apicomplexan metabolism
    Stacy S Hung
    Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada
    Trends Parasitol 27:131-40. 2011
    The phylum Apicomplexa comprises over 5000 species of obligate intracellular parasites, many responsible for diseases that significantly impact human health and economics...
  35. ncbi GpMyoF, a WD40 repeat-containing myosin associated with the myonemes of Gregarina polymorpha
    Matthew B Heintzelman
    Department of Biology, Program in Cell Biology and Biochemistry, Bucknell University, Lewisburg, Pennsylvania 17837, USA
    J Parasitol 94:158-68. 2008
    ..novel myosin and its homologs, which have been identified in several related genera, appear to be unique to the Apicomplexa and represent the only myosins known to contain the WD40 domain. The function of this myosin in G...
  36. pmc More membranes, more proteins: complex protein import mechanisms into secondary plastids
    Swati Agrawal
    Department of Cellular Biology, University of Georgia, 500 D W Brooks Drive, Athens, GA 30602, USA
    Protist 161:672-87. 2010
    ..and seeks to provide a brief overview of plastid evolution in particular for readers not already familiar with plant and algal biology and then focuses on recent molecular discoveries using genetically tractable Apicomplexa and diatoms.
  37. ncbi Role of the parasite and host cytoskeleton in apicomplexa parasitism
    Karine Frénal
    Department of Microbiology and Molecular Medicine, CMU, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Cell Host Microbe 5:602-11. 2009
    The phylum Apicomplexa includes a large and diverse group of obligate intracellular parasites that rely on actomyosin-based motility to migrate, enter host cells, and egress from infected cells...
  38. pmc ApicoAP: the first computational model for identifying apicoplast-targeted proteins in multiple species of Apicomplexa
    Gokcen Cilingir
    School of Electrical Engineering and Computer Science, Washington State University, Pullman, Washington, United States of America
    PLoS ONE 7:e36598. 2012
    Most of the parasites of the phylum Apicomplexa contain a relict prokaryotic-derived plastid called the apicoplast...
  39. ncbi Autophagy in Apicomplexa: a life sustaining death mechanism?
    Anthony P Sinai
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40526, USA
    Trends Parasitol 28:358-64. 2012
    ..from Plasmodium suggest that autophagy-related processes may serve as an additional death promoting pathway in Apicomplexa. Detailed mechanistic studies into the molecular basis for PCD in parasitic protozoa represent a fertile area ..
  40. ncbi Parasites of the Asian tiger mosquito and other container-inhabiting mosquitoes (Diptera:Culicidae) in northcentral Florida
    T Fukuda
    Center for Medical, Agricultural and Veterinary Entomology, USDA ARS, Gainesville, FL 32604, USA
    J Med Entomol 34:226-33. 1997
    ..A. taiwanensis, S. culisetae, and the vibrio bacterium previously have been reported from Ae. albopictus. This is the 1st report of the other 4 microorganisms parasitizing Ae. albopictus larvae...
  41. ncbi Long-term occurrence of Hemolivia cf. mauritanica (Apicomplexa: Adeleina: Haemogregarinidae) in captive Testudo marginata (Reptilia: Testudinidae): evidence for cyclic merogony?
    P Siroky
    Department of Biology and Wildlife Diseases, University of Veterinary and Pharmaceutical Sciences, Palackeho 1 3, 612 42 Brno, Czech Republic
    J Parasitol 90:1391-3. 2004
    ....
  42. ncbi Morphological analysis of the cellular interactions between the eugregarine Gregarina garnhami (Apicomplexa) and the epithelium of its host, the desert locust Schistocerca gregaria
    Andrea Valigurová
    Department of Botany and Zoology, Faculty of Science, Masaryk University, Kotlarska 2, 611 37 Brno, Czech Republic
    Eur J Protistol 44:197-207. 2008
    ..In individuals already detached from the host epithelium, a central depression remained at the top of their protomerite, in the area formerly bearing the epimerite...
  43. pmc Structural and evolutionary divergence of eukaryotic protein kinases in Apicomplexa
    Eric Talevich
    Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA
    BMC Evol Biol 11:321. 2011
    The Apicomplexa constitute an evolutionarily divergent phylum of protozoan pathogens responsible for widespread parasitic diseases such as malaria and toxoplasmosis...
  44. pmc The development of Psychodiella sergenti (Apicomplexa: Eugregarinorida) in Phlebotomus sergenti (Diptera: Psychodidae)
    Lucie Lantová
    Department of Parasitology, Faculty of Science, Charles University in Prague, Czech Republic
    Parasitology 139:726-34. 2012
    ..It develops sexually exclusively in sand fly females that took a bloodmeal, and its sporozoites bear a distinctive conoid (about 700 nm long), which is more than 4 times longer than conoids of the mosquito gregarines...
  45. ncbi Epimerite-host epithelium relationships among eugregarines parasitizing the damselflies Enallagma civile and Ischnura verticalis
    J Janovy
    School of Biological Sciences, University of Nebraska-Lincoln, 68588-0118, USA
    J Parasitol 87:988-96. 2001
    ..nebraskensis, and deeply embedded epimerites inserted within or between host cells, as in the other species studied...
  46. pmc Full-parasites: database of full-length cDNAs of apicomplexa parasites, 2010 update
    Josef Tuda
    Faculty of Medicine, Sam Ratulangi University, Kampus Unsrat, Bahu Manado 95115, Indonesia
    Nucleic Acids Res 39:D625-31. 2011
    Full-Parasites (http://fullmal.hgc.jp/) is a transcriptome database of apicomplexa parasites, which include Plasmodium and Toxoplasma species...
  47. ncbi Evolution of the Apicomplexa: where are we now?
    David A Morrison
    Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Trends Parasitol 25:375-82. 2009
    The Apicomplexa is the only large taxonomic group whose members are entirely parasitic and is, therefore, presumably of major interest to parasitologists...
  48. ncbi Investigating phylogenetic relationships within the Apicomplexa using sequence data: the search for homology
    J R Barta
    Department of Pathobiology, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Methods 13:81-8. 1997
    ..The selection of suitable gene targets (commonly 18S small subunit rRNA gene sequences in the Apicomplexa) and appropriate ingroup and outgroup taxa will affect the ability to align sequences unambiguously...
  49. ncbi Host cell invasion by apicomplexans: what do we know?
    Daniel Bargieri
    Institut Pasteur, Unité de Biologie et Génétique du Paludisme, 75015 Paris, France
    Trends Parasitol 28:131-5. 2012
    ..However, more recent work questions this view. Here, we critically discuss the current model and speculate on alternative models of the AMA1-RON association and of the apicomplexan TJ...
  50. doi The first report of Hepatozoon sp. (Apicomplexa: Hepatozoidae) in neotropical felids from Brazil
    Betina Metzger
    Vet Parasitol 152:28-33. 2008
    ..from domestic cats in Spain. Hepatozoon species from Neotropical felids were identified molecularly and characterized for the first time. This is also the first report of Hepatozoon infection in a little spotted cat...
  51. pmc ApiDB: integrated resources for the apicomplexan bioinformatics resource center
    Cristina Aurrecoechea
    Center for Tropical and Emerging Global Diseases, Athens, GA, USA
    Nucleic Acids Res 35:D427-30. 2007
    ..The phylum Apicomplexa comprises numerous veterinary and medically important parasitic protozoa including human pathogenic species of ..
  52. ncbi The rhoptry neck protein RON4 re-localizes at the moving junction during Toxoplasma gondii invasion
    Maryse Lebrun
    UMR 5539 CNRS, Université de Montpellier 2, CP 107, Place Eugene Bataillon, 34090 Montpellier, France
    Cell Microbiol 7:1823-33. 2005
    Host cell invasion in the Apicomplexa is unique in its dependency on a parasite actin-driven machinery and in the exclusion of most host cell membrane proteins during parasitophorous vacuole (PV) formation...
  53. ncbi Hematozoa of teleosts from Lizard Island, Australia, with some comments on their possible mode of transmission and the description of a new hemogregarine species
    Nico J Smit
    Department of Zoology, University of Johannesburg, P O Box 524, Auckland Park 2006, South Africa
    J Parasitol 92:778-88. 2006
    ..bigemina-like hemogregarine, contained hemogregarine gamonts and possibly young oocysts up to 3 days postfeeding, but no firm evidence that gnathiids transmit hemogregarines at Lizard Island was obtained...
  54. ncbi Principles of protein and lipid targeting in secondary symbiogenesis: euglenoid, dinoflagellate, and sporozoan plastid origins and the eukaryote family tree
    T Cavalier-Smith
    Department of Botany, University of British Columbia, Vancouver, British Columbia, V6T 124, Canada
    J Eukaryot Microbiol 46:347-66. 1999
    ....
  55. pmc Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis
    Lina Tawk
    UMR 5235 CNRS, Universite Montpellier 1 and 2, Montpellier, France
    PLoS Pathog 7:e1001286. 2011
    ..This study also highlights the possibility of developing specific pharmacological inhibitors of the parasite PI3-kinase as novel anti-apicomplexan drugs...
  56. ncbi Sexual differentiation and sex determination in the Apicomplexa
    Todd G Smith
    Clinical Science Division, Medical Sciences Building, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A5
    Trends Parasitol 18:315-23. 2002
    Protozoan parasites of the phylum Apicomplexa have complex life cycles involving various types of asexual division that allow rapid proliferation of parasites within one or more hosts...
  57. ncbi Organelle-specific cochaperonins in apicomplexan parasites
    Shigeharu Sato
    Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Mol Biochem Parasitol 141:133-143. 2005
    ..The apicomplexan Cpn10 is phylogenetically related to other mitochondrial versions but a significant relationship between apicomplexan Cpn20s and other cochaperonins was not established...
  58. ncbi Molecular systematics of marine gregarines (Apicomplexa) from North-eastern Pacific polychaetes and nemerteans, with descriptions of three novel species: Lecudina phyllochaetopteri sp. nov., Difficilina tubulani sp. nov. and Difficilina paranemertis sp. n
    Sonja Rueckert
    Canadian Institute for Advanced Research, Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    Int J Syst Evol Microbiol 60:2681-90. 2010
    ..nov. (which lacked epicytic folds), Lecudina tuzetae, species of the genus Lankesteria and several sequences derived from previous environmental DNA surveys of marine biodiversity...
  59. ncbi Intraerythrocytic merogony in Haemogregarina koppiensis (Apicomplexa: Adeleorina: Haemogregarinidae)
    Nico J Smit
    Marine Biology Research Institute, Department of Zoology, University of Cape Town, Rondebosch, South Africa
    Folia Parasitol (Praha) 52:277-8. 2005
    ..Identical merozoites, usually in clusters of up to 16, were also observed free of host cells. The pattern of merogony seen in H. koppiensis is unusual for a fish haemogregarine...
  60. ncbi Co-distribution pattern of a haemogregarine Hemolivia mauritanica (Apicomplexa: Haemogregarinidae) and its vector Hyalomma aegyptium (Metastigmata: Ixodidae)
    Pavel Siroký
    Department of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1 3, 612 42 Brno, Czech Republic
    J Parasitol 95:728-33. 2009
    ..Identical host preferences of H. aegyptium and H. mauritanica suggest the occurrence of co-evolution within the Testudo-Hyalomma-Hemolivia host-parasite complex...
  61. ncbi Whole-genome natural histories of apicomplexan surface proteins
    Thomas J Templeton
    Weill Cornell Medical College, Department of Microbiology and Immunology, 1300 York Avenue, Box 62, New York, NY 10021, USA
    Trends Parasitol 23:205-12. 2007
    ....
  62. ncbi The glideosome: a molecular machine powering motility and host-cell invasion by Apicomplexa
    Anthony Keeley
    Department of Biological Sciences, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, London SW7 2AZ, UK
    Trends Cell Biol 14:528-32. 2004
    ....
  63. pmc The Apicomplexan whole-genome phylogeny: an analysis of incongruence among gene trees
    Chih Horng Kuo
    Department of Genetics, University of Georgia, USA
    Mol Biol Evol 25:2689-98. 2008
    The protistan phylum Apicomplexa contains many important pathogens and is the subject of intense genome sequencing efforts...
  64. pmc Novel components of the Apicomplexan moving junction reveal conserved and coccidia-restricted elements
    Kurtis W Straub
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095 1489, USA
    Cell Microbiol 11:590-603. 2009
    ..of the Toxoplasma MJ have orthologues in Plasmodium, indicating a conserved structure throughout the Apicomplexa. We report here two novel MJ proteins, RON5 and RON8...
  65. ncbi Dense granules: are they key organelles to help understand the parasitophorous vacuole of all apicomplexa parasites?
    Corinne Mercier
    Institut Jean Roget, Universite Joseph Fourier, CNRS UMR 5163, Place du Commandant Nal, 38700 La Tronche, France
    Int J Parasitol 35:829-49. 2005
    Together with micronemes and rhoptries, dense granules are specialised secretory organelles of Apicomplexa parasites...
  66. ncbi Purification and molecular characterization of cGMP-dependent protein kinase from Apicomplexan parasites. A novel chemotherapeutic target
    Anne M Gurnett
    Department of Human and Animal Infectious Disease Research, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Biol Chem 277:15913-22. 2002
    ..Compound 1 is a potent inhibitor of both soluble and membrane-associated isoforms of native PKG, as well as recombinant enzyme, with an IC(50) of <1 nm...
  67. ncbi The apicoplast: a plastid in Plasmodium falciparum and other Apicomplexan parasites
    Bernardo J Foth
    Plant Cell Biology Research Centre, School of Botany, University of Melbourne, Parkville, Victoria 3010, Australia
    Int Rev Cytol 224:57-110. 2003
    ..Some antibiotics inhibiting these molecular processes are already in chemotherapeutic use, whereas many new drugs will hopefully spring from our growing understanding of this intriguing organelle...
  68. ncbi Evolution of the apicoplast and its hosts: from heterotrophy to autotrophy and back again
    Miroslav Obornik
    Biology Centre, Academy of Sciences of Czech Republic, Institute of Parasitology, and University of South Bohemia, Faculty of Science, Branisovska 31, 37005, Ceske Budejovice, Czech Republic
    Int J Parasitol 39:1-12. 2009
    ..Here we review our knowledge on the evolutionary history of Apicomplexa and particularly their plastids, with a focus on the pathway by which they evolved from free-living ..
  69. ncbi Apicomplexan plastids as drug targets
    G I McFadden
    Plant Cell Biology Research Center, School of Botany, University of Melbourne, Parkville, VIC 3052, Australia
    Trends Microbiol 7:328-33. 1999
    ..The parasiticidal activity of several herbicides and antibacterial antibiotics is suspected to be a result of their ability to inhibit key plastid activities...
  70. ncbi Apical organelles and host-cell invasion by Apicomplexa
    J F Dubremetz
    Unite 42 INSERM, Villeneuve d Ascq, France
    Int J Parasitol 28:1007-13. 1998
    ..The development of parasite transformation by gene transfection has provided powerful tools to analyze the fate and function(s) of the corresponding proteins...
  71. pmc Building the perfect parasite: cell division in apicomplexa
    Boris Striepen
    Center for Tropical and Emerging Global Diseases and the Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America
    PLoS Pathog 3:e78. 2007
    ....
  72. ncbi Apicoplast: keep it or leave it
    Tobias Fleige
    Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Microbes Infect 12:253-62. 2010
    ..The tasks of this organelle is compared across the phylum of Apicomplexa, highlighting its role in metabolic adaptation to different intracellular niches.
  73. ncbi Apicomplexa, trypanosoma and parasitic nematode protein kinases as antiparasitic therapeutic targets
    Fina Liotta
    Montclair State University, Sokol Institute of Pharmaceutical Life Sciences and Department of Chemistry and Biochemistry, 1 Normal Avenue, Montclair, NJ 07043, USA
    Curr Opin Investig Drugs 11:147-56. 2010
    ..The aim of recent target-based approaches used in the development of parasite kinase inhibitors is to identify novel antiparasitic agents with therapeutic potential...
  74. ncbi Host cell invasion by the apicomplexans: the significance of microneme protein proteolysis
    Timothy Dowse
    Department of Biological Sciences, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, London SW7 2AZ, UK
    Curr Opin Microbiol 7:388-96. 2004
    ..These proteases may constitute potential drug targets for intervention against malaria and other diseases caused by these parasites...
  75. ncbi Cellular polyamine profile of the phyla Dinophyta, Apicomplexa, Ciliophora, Euglenozoa, Cercozoa and Heterokonta
    Koei Hamana
    Gunma University School of Health Sciences, Maebashi, Gunma 371 8514, Japan
    J Gen Appl Microbiol 50:297-303. 2004
  76. pmc A genome-sequence survey for Ascogregarina taiwanensis supports evolutionary affiliation but metabolic diversity between a Gregarine and Cryptosporidium
    Thomas J Templeton
    Department of Microbiology and Immunology, Weill Cornell Medical College, USA
    Mol Biol Evol 27:235-48. 2010
    ..to this early diverging apicomplexan and properties that unite it with Cryptosporidium, the Coccidia, and the Apicomplexa. Phylogenetic trees inferred from a concatenated protein sequence comprised of 10,750 amino acid positions, as ..
  77. pmc Full-Malaria/Parasites and Full-Arthropods: databases of full-length cDNAs of parasites and arthropods, update 2009
    Hiroyuki Wakaguri
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo 4 6 1, Shirokanedai, Minatoku, Tokyo 108 8639, Japan
    Nucleic Acids Res 37:D520-5. 2009
    Full-Malaria/Parasites is a database for transcriptome studies of apicomplexa and other parasites, which is based on our original full-length cDNA sequences and physical cDNA clone resources...
  78. ncbi Apicomplexa in mammalian cells: trafficking to the parasitophorous vacuole
    Marie France Cesbron-Delauw
    Laboratoire Adaptation et Pathogenie des Microorganismes, CNRS UMR 5163, Universite Joseph Fourier Grenoble 1, BP 170, 38042 Grenoble Cedex 9, France
    Traffic 9:657-64. 2008
    Most Apicomplexa reside and multiply in the cytoplasm of their host cell, within a parasitophorous vacuole (PV) originating from both parasite and host cell components...
  79. ncbi Acquisition and transmission of Hepatozoon canis (Apicomplexa: Hepatozoidae) by the tick Amblyomma ovale (Acari: Ixodidae)
    A S Rubini
    Departamento de Parasitologia, Instituto de Biociencias, Universidade Estadual Paulista Julio de Mesquita Filho, Distrito de Rubiao Jr s n, CEP 18618 000, Botucatu, Sao Paulo, Brazil
    Vet Parasitol 164:324-7. 2009
    ..canis by DNA sequencing. The results obtained indicated A. ovale ticks as potential vector of H. canis in rural areas of Brazil...
  80. ncbi Plastids are widespread and ancient in parasites of the phylum Apicomplexa
    N Lang-Unnasch
    Department of Medicine, University of Alabama at Birmingham 35294 2170, USA
    Int J Parasitol 28:1743-54. 1998
    ..Taken together, these data support a single ancient lineage for the plastids of parasites in the phylum Apicomplexa.
  81. ncbi A new fish haemogregarine from South Africa and its suspected dual transmission with trypanosomes by a marine leech
    Polly M Hayes
    School of Life Sciences, Kingston University, Kingston upon Thames, Surrey KT1 2EE, UK
    Folia Parasitol (Praha) 53:241-8. 2006
    ..It is suspected that Z. arugamensis transmits the haemogregarine and trypanosomes simultaneously between fishes, a double event unreported previously from the marine environment...
  82. pmc Inconsistencies of genome annotations in apicomplexan parasites revealed by 5'-end-one-pass and full-length sequences of oligo-capped cDNAs
    Hiroyuki Wakaguri
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwanoha, Kashiwa, Chiba, Japan
    BMC Genomics 10:312. 2009
    ..We generated 5'-EST collections for six apicomplexa parasites using our full-length oligo-capping cDNA library method...
  83. ncbi The life cycle of haemogregarina bigemina (Adeleina: Haemogregarinidae) in South African hosts
    A J Davie
    School of Life Sciences, Faculty of Science, Kingston University, Kingston upon Thames, Surrey, UK
    Folia Parasitol (Praha) 48:169-77. 2001
    ..The presence of intraerythrocytic binary fission in its fish host means that H. bigemina is not a Desseria. Overall it most closely resembles Haemogregarina (sensu stricto) in its development, although the match is not exact...
  84. pmc Comparasite: a database for comparative study of transcriptomes of parasites defined by full-length cDNAs
    Junichi Watanabe
    Department of Parasitology, Institute of Medical Science, Graduate School of Frontier Sciences, University of Tokyo, 4 6 1, Shirokanedai, Minatoku, Tokyo 108 8639, Japan
    Nucleic Acids Res 35:D431-8. 2007
    ..Putatively counterpart gene groups are clustered and comparative analysis of any combination of six apicomplexa species is implemented, such as interspecies comparisons regarding protein motifs (InterPro), predicted ..
  85. ncbi The plant-type ferredoxin-NADP+ reductase/ferredoxin redox system as a possible drug target against apicomplexan human parasites
    Frank Seeber
    FB Biologie Parasitologie, Philipps Universitat Marburg, Karl von Frisch Strasse, 35032 Marburg, Germany
    Curr Pharm Des 11:3159-72. 2005
    b>Apicomplexa are unicellular, obligate intracellular parasites of great medical importance. They include human pathogens like Plasmodium spp...
  86. ncbi The Hsp40 proteins of Plasmodium falciparum and other apicomplexa: regulating chaperone power in the parasite and the host
    M Botha
    Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown 6140, South Africa
    Int J Biochem Cell Biol 39:1781-803. 2007
    ..Comparison of the Hsp40 proteins of P. falciparum to those of other apicomplexa reveals that most of the proteins (especially the PEXEL/HT-containing proteins) are unique to P. falciparum...
  87. ncbi Endogenous development of Hemolivia mauritanica (Apicomplexa: Adeleina: Haemogregarinidae) in the marginated tortoise Testudo marginata (Reptilia: Testudinidae): evidence from experimental infection
    Pavel Siroký
    Department of Biology and Wildlife Diseases, University of Veterinary and Pharmaceutical Sciences, Palackeho 1 3, 612 42 Brno, Czech Republic
    Folia Parasitol (Praha) 54:13-8. 2007
    ..The role of individual developmental stages of haemogregarines is discussed with respect to evolution of heteroxenous life cycle and long-term persistence of parasites in their intermediate hosts...
  88. ncbi Lipid biology of Apicomplexa: perspectives for new drug targets, particularly for Toxoplasma gondii
    Sabrina Sonda
    Institute of Parasitology, University of Zurich, Winterthurerstrasse 266a, CH 8057 Zurich, Switzerland
    Trends Parasitol 22:41-7. 2006
    ..gondii lipid biology. Recent achievements in this field are promising and suggest that the elucidation of lipid pathways will provide new opportunities for designing potent antiparasitic strategies...
  89. pmc Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites
    Alexandre Bougdour
    UMR, Centre National de la Recherche Scientifique, Universite Joseph Fourier Grenoble, France
    J Exp Med 206:953-66. 2009
    Plasmodium and Toxoplasma are parasites of major medical importance that belong to the Apicomplexa phylum of protozoa...
  90. ncbi Epigenetics in Apicomplexa: control of gene expression during cell cycle progression, differentiation and antigenic variation
    Mohamed Ali Hakimi
    UMR5163 CNRS UJF, Jean Roget Institute, Grenoble, France
    Curr Opin Microbiol 10:357-62. 2007
    ..Here we review recent advances in the study of epigenetic gene regulation in the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii...
  91. ncbi Analysis of gene expression during development: lessons from the Apicomplexa
    Jon P Boyle
    Department of Microbiology and Immunology, Fairchild Building D305, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305 5124, USA
    Microbes Infect 8:1623-30. 2006
    ....
  92. ncbi Mix and match modules: structure and function of microneme proteins in apicomplexan parasites
    F M Tomley
    Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berkshire, UK RG16 0NN
    Trends Parasitol 17:81-8. 2001
    ..This supports the idea that the mechanism of host cell invasion across the phylum is conserved not only morphologically, but also functionally at the molecular level. Here, we review and summarize these recent findings...
  93. ncbi The cell biology of secondary endosymbiosis--how parasites build, divide and segregate the apicoplast
    Shipra Vaishnava
    Department of Cellular Biology, University of Georgia, Paul D Coverdell Center, 500 D W Brooks Drive, Athens, GA 30602, USA
    Mol Microbiol 61:1380-7. 2006
    Protozoan parasites of the phylum Apicomplexa harbour a chloroplast-like organelle, the apicoplast...
  94. ncbi 'Total evidence' refutes the inclusion of Perkinsus species in the phylum Apicomplexa
    M E Siddall
    Virginia Institute of Marine Science, College of William and Mary, Gloucester Point 23062, USA
    Parasitology 115:165-76. 1997
    ..that Perkinsus species do not have a conoid and that other criteria which have been used to place them in the Apicomplexa are general to alveolates...
  95. pmc Comparative analysis of apicomplexa and genomic diversity in eukaryotes
    Thomas J Templeton
    Department of Microbiology and Immunology, Weill Medical College and the Program in Immunology and Microbial Pathogenesis, Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021, USA
    Genome Res 14:1686-95. 2004
    ..We also describe additional molecular characteristics distinguishing Apicomplexa from other eukaryotes for which complete genome sequences are available.
  96. pmc Conservation and divergence of known apicomplexan transcriptional regulons
    Kobby Essien
    Department of Bioengineering, University of Pennsylvania, 240 SkirkanichHall, Philadelphia, Pennsylvania 19104, USA
    BMC Genomics 11:147. 2010
    ..Even less is known about how regulon systems, consisting of transcription factors and target genes together with their associated biological process, evolve in these diverse parasites...
  97. ncbi Efficacy of oral sulfadimethoxine against two gregarine parasites, Protomagalhaensia granulosae and Gregarina cubensis (Apicomplexa: Eugregarinida), infecting the Death's Head cockroach, Blaberus discoidalis
    R E Clopton
    Department of Natural Science, Peru State College, Peru, Nebraska 68421, USA
    J Parasitol 88:786-9. 2002
    ....
  98. ncbi Migration through host cells by apicomplexan parasites
    M M Mota
    Department of Pathology, New York University, 550 First Avenue, New York, NY 10016, USA
    Microbes Infect 3:1123-8. 2001
    ..Here we revisit the existing literature that supports the presence of similar invasive behaviors in other apicomplexan parasites...
  99. ncbi The phylogeny of colpodellids (Alveolata) using small subunit rRNA gene sequences suggests they are the free-living sister group to apicomplexans
    Olga N Kuvardina
    Canadian Institute for Advanced Research, Program in Evolutionary Biology, Department of Botany, University of British Columbia, Vancouver BC V6T 1Z4, Canada
    J Eukaryot Microbiol 49:498-504. 2002
    ..This ancestor also very likely contained a plastid, but it is presently not certain whether it was photosynthetic, and it is not clear whether extant perkinsids or colpodellids have retained the organelle...
  100. ncbi Comment on "A green algal apicoplast ancestor"
    Ross F Waller
    Department of Biochemistry and, Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia
    Science 301:49; author reply 49. 2003
  101. ncbi The cytoskeleton and motility in apicomplexan invasion
    Ruth E Fowler
    Malaria Laboratory, Peter Gorer Department of Immunobiology, Guy s, King s College and St Thomas s Hospitals School of Medicine, New Guy s House, Guy s Hospital, London, SE1 9RT, UK
    Adv Parasitol 56:213-63. 2004
    We consider the cytoskeletal structure, function, and motility of the invasive zoites of the Apicomplexa. This monophyletic group possess a prominent microtubular cytoskeleton, with a very distinct polarity...

Research Grants62

  1. A Systems Biology Approach to the Model Apicomplexan Toxoplasma gondii
    William J Sullivan Jr; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This application focuses upon the Apicomplexa, etiologic agents of many diseases in the developing world and relevant to global health (thematic area 4)...
  2. Toxoplasma Epigenomics and Gene Expression
    Kami Kim; Fiscal Year: 2013
    ..gondii and other Apicomplexa. We hypothesize that conserved Apicomplexa AP2 family members have conserved functions in T...
  3. A Heterologous Expression System for Apicomplexa Genes
    JOSE A FERNANDEZ ROBLEDO; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The phylum Apicomplexa is constituted exclusively by protozoan parasites, several of which pose a significant threat to public health...
  4. How do you build a parasite?
    John Murray; Fiscal Year: 2009
    ..In addition to Toxoplasma, the protozoan phylum Apicomplexa includes many other parasites of clinical and/or veterinary importance...
  5. Dissecting a novel mechanism of drug-induced death in Toxoplasma gondii
    GUSTAVO A ARRIZABALAGA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Apicomplexa comprise a medically important phylum of obligate intracellular parasites, including Plasmodium falciparum, the causative agent of malaria, Cryptosporidium, which causes ..
  6. The plant-like vacuole of Toxoplasma gondii
    Silvia N Moreno; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Toxoplasma gondii belongs to the phylum Apicomplexa and is an important cause of congenital disease and infection in immunocompromised patients...
  7. The AP2 factors required for Toxoplasma replication
    Michael W White; Fiscal Year: 2013
    ..Transcription in apicomplexa pathogens is poorly understood, however, the recent discovery of plant-like transcription factors in the ..
  8. Identifying components of Toxoplasma oocysts that confer environmental resistance
    HEATHER MICHELLE FRITZ; Fiscal Year: 2013
    DESCRIPTION (provided by applicant: Toxoplasma gondii is an obligate intracellular parasite in the family Apicomplexa that infects a broad range of warm-blooded animals, including humans...
  9. MYST opportunities for Toxoplasma drug development
    William J Sullivan Jr; Fiscal Year: 2010
    Pathogenic eukaryotes in the phylum Apicomplexa include some of the most notorious protozoan parasites, such as Plasmodium (malaria), Cryptosporidium (diarrheal disease), and Toxoplasma (toxoplasmic encephalitis)...
  10. Biology of the Apicomplexan Plastid
    Boris Striepen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Apicomplexa are responsible for a number of important human diseases including malaria, toxoplasmosis, cryptosporidiosis and cyclosporidiosis...
  11. Molecular mechanisms of pathogenesis in Toxoplasma
    Jon P Boyle; Fiscal Year: 2010
    ..T. gondii is a member of the phylum Apicomplexa which includes other human parasites, including the causative agents of malaria and cryptosporidiosis...
  12. Toxoplasma strain-specific modulation of mouse immune cells
    JEROEN SAEIJ; Fiscal Year: 2013
    ..ability to co-opt host signaling pathways for the parasite's own purposes is likely to be found in other Apicomplexa that are also living within a membrane-limited vacuole, for example, Plasmodium species as they grow within ..
  13. Targeting Host and Apicomplexan Isoprenoid Pathways
    Silvia N Moreno; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Apicomplexa are important pathogens that include the causative agents of malaria, toxoplasmosis, and cryptosporidiosis...
  14. Cytoskeleton scaffold assembly in Toxoplasma gondii
    Marc Jan Gubbels; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Limited treatment options are available to treat disease caused by Apicomplexa. We propose to study the internal budding process of the model parasite Toxoplasma gondii, in particular the ..
  15. Manipulation of host cell acetylome in AIDS opportunistic infection
    William J Sullivan; Fiscal Year: 2013
    ..Toxoplasma gondii is an obligate intracellular protozoan parasite (phylum Apicomplexa) that has permanently infected up to 1/3 of the world's population...
  16. Toxoplasma gondii: cyst wall
    Louis M Weiss; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Toxoplasma gondii, a member of the Apicomplexa, is a ubiquitous parasite of mammals...
  17. The Role of Toxoplasma Rhoptries in Host Cell Infection
    PETER JOHN BRADLEY; Fiscal Year: 2013
    ..As the remaining members are conserved in the Apicomplexa and believed to be essential, this indicates that apicomplexans contain a conserved core complex that is ..
  18. Dissecting the roles of protein O-GlcNAcylation in Toxoplasma gondii
    Peng Wu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Toxoplasma gondii is an obligate intracellular parasite in the phylum Apicomplexa. This parasite causes life-threatening diseases in AIDS patients and immune-compromised individuals, and birth ..
  19. The role of the DOC2.1 protein in Toxoplasma gondii Ca2+- dependent exocytosis
    Marc Jan Gubbels; Fiscal Year: 2013
    ..1. Comparative genomics of TgDOC2.1 identified four conserved sequence block across the Apicomplexa, highlighting a potentially crucial role for these domains (block 2 contains the DOC2 domain)...
  20. Microsporidia: Genetic Techniques
    Louis M Weiss; Fiscal Year: 2012
    ..take advantage of the experience of our collaborators in the development of transfection systems for various Apicomplexa and our characterization of the E. cuniculi and E. hellem genomic rRNA loci...
  21. Toxoplasma Rhoptry Function
    John C Boothroyd; Fiscal Year: 2013
    ..These club-shaped structures are found at the apical end of all members of the Apicomplexa, including the causative agent of human malaria, Plasmodium...
  22. Novel activities and the T. gondii vacuolar membrane
    Anthony P Sinai; Fiscal Year: 2012
    ..While several appear unique to Toxoplasma, others have similarly annotated homologs in other less tractable Apicomplexa including Plasmodium and Cryptosporidium spp. suggesting conserved function...
  23. How Toxoplasma injects rhoptry proteins into the host cell
    FELICE DEBORAH KELLY; Fiscal Year: 2013
    ..This machinery is likely to be conserved throughout the Apicomplexa family, just as the invasion machinery is, and proteins identified here may help us understand the invasion of ..
  24. The Role of NKG2D/DAP10 in Toxoplasma gondii Infection
    RACHEL MARGARET PRESTI; Fiscal Year: 2010
    ..The Apicomplexa consist of numerous protozoa which cause disease, including Plasmodium, Toxoplasma, Cryptosporidia, and Babesia...
  25. DRUG DISCOVERY--POLYAMINE METABOLISM OF CRYPTOSPORIDIUM
    JANET KEITHLY; Fiscal Year: 1999
    ..parvum for its potential as a chemotherapeutic target. Our consortium has shown that within the Apicomplexa, C: parvum has a type of polyamine metabolism usually found only in photosynthetic eukaryotes and certain ..
  26. TRAP AS A CANDIDATE MALARIA VACCINE
    Victor Nussenzweig; Fiscal Year: 2000
    ..additionally required for infectivity: TRAP (-) parasites do not exhibit the characteristic gliding motility of Apicomplexa, and do not infect the salivary glands of mosquitoes or the liver of the mammalian host...
  27. TOXOPLASMA INVASION INTO HOST CELLS--PROTEIN KINASE C
    CORNELIS BECKERS; Fiscal Year: 2001
    ..Toxoplasma, like the other member of the phylum Apicomplexa, such as Plasmodium and Cryptosporidium, is an oblegate intracellular parasite that actively invades its ..
  28. Toxoplasma gondii Egress
    Gustavo Arrizabalaga; Fiscal Year: 2005
    The intracellular infectious agent Toxoplasma gondii is a member of the phylum Apicomplexa, which includes the organisms responsible for malaria and coccidiosis...
  29. IN VITRO STUDIES ON CRYPTOSPORIDIUM, AN OI OF AIDS
    STEVE UPTON; Fiscal Year: 1993
    Cryptosporidium parvum (Apicomplexa) has emerged as an important opportunistic pathogen of patients suffering from the Acquired Immunodeficiency Syndrome (AIDS)...
  30. GENE DISCOVERY IN TOXOPLASMA GONDII
    L Sibley; Fiscal Year: 1999
    ..Abstract): Toxoplasma gondii is a model system for genetic analyses in parasites belonging to the phylum Apicomplexa, a group that includes malaria and several additional human and animal pathogens. Like other apicomplexans, T...
  31. PROTEIN TARGETING TO THE TOXOPLASMA GONDII PLASTID
    Marilyn Parsons; Fiscal Year: 2000
    ..Both organisms belong to the phylum Apicomplexa, whose members (including the causative agent of malaria) have recently been shown to contain a unique plastid-..
  32. TARGETING OF NUCLEAR ENCODED PROTEINS
    Naomi Lang Unnasch; Fiscal Year: 2003
    DESCRIPTION (Adapted from the Applicant's Abstract): Parasites in the phylum apicomplexa contain a novel organelle, which appears to be a non-photosynthetic remnant of a plastid...
  33. THE GLIDING MOTILITY AND CELL INVASION BY PLASMODIUM
    Victor Nussenzweig; Fiscal Year: 2006
    b>Apicomplexa do not have cilia or flagella but glide rapidly on solid substrates. The molecular mechanism of this unique type of motility is obscure...
  34. APEs as novel drug targets in AIDS opportunistic pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2008
    unreadable] DESCRIPTION (Provided by Applicant): New drugs against parasitic protozoa of phylum Apicomplexa are urgently needed...
  35. Mucosal Immunity to Toxoplasma gondii
    L Sibley; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  36. Protein targeting and secretion in Toxoplasma
    Boris Striepen; Fiscal Year: 2004
    ..Mutant analysis will also provide critical information towards the function of the individual secretory organelles involved. ..
  37. IMPDH as a Drug Target in Cryptosporidium
    Boris Striepen; Fiscal Year: 2008
    ..This work will provide urgently needed molecular reagents to understand the biology of nutrient uptake and drug resistance in this unique parasite. [unreadable] [unreadable] [unreadable]..
  38. GENE DISCOVERY IN TOXOPLASMA GONDII
    L Sibley; Fiscal Year: 2003
    Toxoplasma gondii is a model system for genetic analyses in parasites belonging to the phylum Apicomplexa, a group that includes malaria and several additional human and animal pathogens. Like other apicomplexans, T...
  39. Ninth International Congress on Toxoplasmosis
    Boris Striepen; Fiscal Year: 2007
    ..gondii that is not often seen in fields as high paced and[unreadable] competitive and has facilitated rapid and sustained progress in research on this pathogen[unreadable] and related parasites. ..
  40. Confocal Microscope for Microbiology
    L Sibley; Fiscal Year: 2002
    ..This instrument will greatly strengthen the research programs of these highly productive groups by applying high-resolution confocal microscopy to the study of human pathogens...
  41. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2008
    ..Thus, our results will fundamentally advance the fields of parasitology and eukaryotic gene expression. ..
  42. Calcium ATPases in Apicomplexan Parasites as Potential D
    L Sibley; Fiscal Year: 2006
    ..Knowledge gained through these studies may improve the ability to pharmacologically inhibit key calcium regulatory enzymes and hence block motility and invasion by this important group of parasites. ..
  43. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2007
    ..Virtually nothing is known about how gene expression is regulated in the Apicomplexa, but the observation that that the antiprotozoal apicidin targets the histone modification machinery argues ..
  44. Purine salvage as a chemotherapeutic target in malaria
    Kami Kim; Fiscal Year: 2002
    ..Inhibitors designed in the Schramm and Grubmeyer laboratories will be tested against P. falciparum cultured in human erythrocytes and in mice infected with P. yoelii, a lethal form of mouse malaria. ..
  45. 7th International Congress on Toxoplasmosis
    Kami Kim; Fiscal Year: 2003
    ..to its clinical importance, Toxoplasma gondii has emerged as a model organism for studies on all of the Apicomplexa as was highlighted in a recent review on development of antimalarials by Robert Ridley (Nature 2002 Feb 7;415(..
  46. SERINE PROTEINASES IN APICOMPLEXAN PARASITES
    Kami Kim; Fiscal Year: 2009
    ..parvum are also category B bioterrorism agents that pose a particular threat to the immunocompromised. The Apicomplexa are named for their unique apical secretory organelles-micronemes, rhoptries and dense granules...
  47. A new family of secreted adhesive proteins in Plasmodium
    THOMAS TEMPLETON; Fiscal Year: 2008
    ..the provenance of extracellular domains likely arising in the parasitic adaptation of the pathogenic Apicomplexa. A select set of genes identified in this analysis share the presence of an LCCL domain and have striking multi-..
  48. Differentiation and Signaling in Toxoplasmosis
    Kami Kim; Fiscal Year: 2008
    ..These studies will further elucidate cAMP signaling pathways in T. gondii and determine the role of cAMP signaling pathways during T. gondii differentiation into latent bradyzoites. ..
  49. TOXOPLASMA DEVELOPMENT AND CELL CYCLE
    Kami Kim; Fiscal Year: 2002
    ..These will be the initial experiments in a long-term effort to define the role of cell cycle regulation in Toxoplasma tachyzoite-bradyzoite differentiation and virulence. ..
  50. Genome Evolution, Innovation and Adaptation in the Apicomplexa
    Jessica C Kissinger; Fiscal Year: 2010
    ..provided by applicant): Diseases caused by unicellular parasitic organisms belonging to the eukaryotic phylum Apicomplexa are notoriously difficult to treat...
  51. GENETIC DISSECTION OF TOXOPLASMA GONDII
    David Roos; Fiscal Year: 2008
    ..In addition to their value for the analysis of folate metabolism and drug resistance, these tools should be broadly applicable to other studies on the biology and biochemistry of Toxoplasma. ..
  52. Novel phospholipases C in trypanosomatids
    Silvia Moreno; Fiscal Year: 2009
    ..abstract_text> ..
  53. Blockade of host apoptosis by Toxoplasma gondii
    Anthony P Sinai; Fiscal Year: 2010
    ..Dissection of these pathways is particularly important given the targets of NFKB many of the cytokines implicated both in the pathogenesis of acute toxoplasmosis and the development of immunity to the parasite. ..
  54. In vitro refinements for Cryptosporidium parvum
    STEVE UPTON; Fiscal Year: 2003
    ..abstract_text> ..
  55. MOLECULAR ANALYSIS OF THE GLYCOSOME.
    Marilyn Parsons; Fiscal Year: 2004
    ..Their studies are aimed at understanding glycosomal biogenesis and protein input and the relationship of these processes and the molecules involved to peroxisome biogenesis in the human host. ..
  56. Cryptosporidium parvum DNA replication proteins
    Guan Zhu; Fiscal Year: 2004
    ..The completion of these aims will not only prove or refute our hypothesis, but also establish a new foundation for the drug discovery targeting the parasite unique DNA mechanism machinery. ..
  57. Mediators of Toxoplasma surviral during infection
    VERNON CARRUTHERS; Fiscal Year: 2004
    ..abstract_text> ..
  58. Proteomic analysis of the T. gondii vacuolar membrane
    Anthony Sinai; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  59. Misregulation of apoptosis in cloned pig embryos
    Heide Schatten; Fiscal Year: 2007
    ..Pilot data from this R03 small grants program research will be used to apply for funding through the R01 mechanism. [unreadable] [unreadable] [unreadable]..
  60. Cryptosporidium parvum Histone Deacetylases
    STANLEY RIDER; Fiscal Year: 2007
    ..There are currently no highly effective treatments for Cryptosporidium parvum. This research is a beginning step toward identifying novel methods to control this parasite. [unreadable] [unreadable] [unreadable]..
  61. PROTEIN PHOSPHORYLATION IN TRYPANOSOMES
    Marilyn Parsons; Fiscal Year: 2010
    ..Together these studies will signficantly expand our knowledge of the network of signaling interactions in trypanosomes, with the goal of identifying new drug and vaccine targets. ..
  62. Fatty Acid Biosynthesis in Cryptosporidium parvum
    Guan Zhu; Fiscal Year: 2010
    ..3) To validate that fatty acid metabolic enzymes may serve as rational drug target in Cryptosporidium by discovering inhibitors selectively against, parasite fatty acid metabolic enzymes. ..