schistosoma mansoni

Summary

Summary: A species of trematode blood flukes of the family Schistosomatidae. It is common in the Nile delta. The intermediate host is the planorbid snail. This parasite causes schistosomiasis mansoni and intestinal bilharziasis.

Top Publications

  1. pmc A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni
    Anna V Protasio
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
    PLoS Negl Trop Dis 6:e1455. 2012
  2. pmc The genome of the blood fluke Schistosoma mansoni
    Matthew Berriman
    Wellcome Trust Sanger Institute, Cambridge CB10 1SD, UK
    Nature 460:352-8. 2009
  3. pmc Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses
    Bart Everts
    Department of Parasitology, Leiden University Medical Centre, Leiden 2333 ZA, The Netherlands
    J Exp Med 206:1673-80. 2009
  4. ncbi An example of molecular co-evolution: reactive oxygen species (ROS) and ROS scavenger levels in Schistosoma mansoni/Biomphalaria glabrata interactions
    Yves Mone
    Parasitologie Fonctionnelle et Evolutive, UMR 5244, CNRS Université de Perpignan, 52 Ave Paul Alduy, 66860 Perpignan Cedex, France
    Int J Parasitol 41:721-30. 2011
  5. ncbi Developing vaccines to combat hookworm infection and intestinal schistosomiasis
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    Nat Rev Microbiol 8:814-26. 2010
  6. ncbi A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization
    Desiree van der Kleij
    Department of Parasitology, Leiden University Medical Center, The Netherlands
    J Biol Chem 277:48122-9. 2002
  7. pmc CD4+CD25+ regulatory cells contribute to the regulation of colonic Th2 granulomatous pathology caused by schistosome infection
    Joseph D Turner
    Centre for Immunology and Infection, Department of Biology, The University of York, York, United Kingdom
    PLoS Negl Trop Dis 5:e1269. 2011
  8. pmc Gene expression patterns in larval Schistosoma mansoni associated with infection of the mammalian host
    Sophia J Parker-Manuel
    University of York, Heslington, United Kingdom
    PLoS Negl Trop Dis 5:e1274. 2011
  9. pmc Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren
    Narcis B Kabatereine
    Vector Control Division, Ministry of Health, Kampala, Uganda
    Bull World Health Organ 85:91-9. 2007
  10. ncbi Abundance of tegument surface proteins in the human blood fluke Schistosoma mansoni determined by QconCAT proteomics
    William Castro-Borges
    Centre for Immunology and Infection, Department of Biology, University of York, Heslington, York, YO10 5DD, UK
    J Proteomics 74:1519-33. 2011

Detail Information

Publications292 found, 100 shown here

  1. pmc A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni
    Anna V Protasio
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
    PLoS Negl Trop Dis 6:e1455. 2012
    ..Amongst the human-infective species, Schistosoma mansoni is also the most commonly used in the laboratory and here we present the systematic improvement of its ..
  2. pmc The genome of the blood fluke Schistosoma mansoni
    Matthew Berriman
    Wellcome Trust Sanger Institute, Cambridge CB10 1SD, UK
    Nature 460:352-8. 2009
    b>Schistosoma mansoni is responsible for the neglected tropical disease schistosomiasis that affects 210 million people in 76 countries. Here we present analysis of the 363 megabase nuclear genome of the blood fluke...
  3. pmc Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses
    Bart Everts
    Department of Parasitology, Leiden University Medical Centre, Leiden 2333 ZA, The Netherlands
    J Exp Med 206:1673-80. 2009
    Soluble egg antigens of the parasitic helminth Schistosoma mansoni (S. mansoni egg antigen [SEA]) induce strong Th2 responses both in vitro and in vivo...
  4. ncbi An example of molecular co-evolution: reactive oxygen species (ROS) and ROS scavenger levels in Schistosoma mansoni/Biomphalaria glabrata interactions
    Yves Mone
    Parasitologie Fonctionnelle et Evolutive, UMR 5244, CNRS Université de Perpignan, 52 Ave Paul Alduy, 66860 Perpignan Cedex, France
    Int J Parasitol 41:721-30. 2011
    ..in the field: the interaction between the mollusc, Biomphalaria glabrata, and its trematode parasite, Schistosoma mansoni. Reactive oxygen species (ROS) produced by the haemocytes of B...
  5. ncbi Developing vaccines to combat hookworm infection and intestinal schistosomiasis
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    Nat Rev Microbiol 8:814-26. 2010
    ..Africa and Brazil, co-infections with the hookworm, Necator americanus, and the intestinal schistosome, Schistosoma mansoni, are common...
  6. ncbi A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization
    Desiree van der Kleij
    Department of Parasitology, Leiden University Medical Center, The Netherlands
    J Biol Chem 277:48122-9. 2002
    ..Taken together, these findings provide evidence for a novel host-parasite interaction that may be central to long term survival of the parasite and limited host pathology with implications beyond parasitology...
  7. pmc CD4+CD25+ regulatory cells contribute to the regulation of colonic Th2 granulomatous pathology caused by schistosome infection
    Joseph D Turner
    Centre for Immunology and Infection, Department of Biology, The University of York, York, United Kingdom
    PLoS Negl Trop Dis 5:e1269. 2011
    Eggs of the helminth Schistosoma mansoni accumulate in the colon following infection and generate Th2-biassed inflammatory granulomas which become down- modulated in size as the infection proceeds to chronicity...
  8. pmc Gene expression patterns in larval Schistosoma mansoni associated with infection of the mammalian host
    Sophia J Parker-Manuel
    University of York, Heslington, United Kingdom
    PLoS Negl Trop Dis 5:e1274. 2011
    ..Patterns of gene expression underlying this transition have been characterised...
  9. pmc Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren
    Narcis B Kabatereine
    Vector Control Division, Ministry of Health, Kampala, Uganda
    Bull World Health Organ 85:91-9. 2007
    ..We aimed to assess the health impact of a national control programme targeting schistosomiasis and intestinal nematodes in Uganda, which has provided population-based anthelmintic chemotherapy since 2003...
  10. ncbi Abundance of tegument surface proteins in the human blood fluke Schistosoma mansoni determined by QconCAT proteomics
    William Castro-Borges
    Centre for Immunology and Infection, Department of Biology, University of York, Heslington, York, YO10 5DD, UK
    J Proteomics 74:1519-33. 2011
    ..Two host IgGs were identified but in amounts much lower than their targets. The findings are interpreted in relation to the models of protective immunity...
  11. pmc IL-10 blocks the development of resistance to re-infection with Schistosoma mansoni
    Mark S Wilson
    Immunopathogensis Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Marlyand, United States of America
    PLoS Pathog 7:e1002171. 2011
    ..This study demonstrates that blocking IL-10 signalling during PZQ treatment can facilitate the development of protective immunity and provide a highly effective strategy to protect against reinfection with S. mansoni...
  12. pmc Influence of exposure history on the immunology and development of resistance to human Schistosomiasis mansoni
    Carla L Black
    Department of Microbiology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America
    PLoS Negl Trop Dis 4:e637. 2010
    ..Previous studies suggest that humans can acquire immunity to reinfection with schistosomes, most probably due to immunologic mechanisms acquired after exposure to dying schistosome worms...
  13. ncbi The influence of sampling effort and the performance of the Kato-Katz technique in diagnosing Schistosoma mansoni and hookworm co-infections in rural Côte d'Ivoire
    M Booth
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Parasitology 127:525-31. 2003
    ..In the case of Schistosoma mansoni, statistical methods have been developed to compensate for the poor sensitivity, but the same is not true ..
  14. ncbi Relative contribution of day-to-day and intra-specimen variation in faecal egg counts of Schistosoma mansoni before and after treatment with praziquantel
    J Utzinger
    Swiss Tropical Institute, Basel
    Parasitology 122:537-44. 2001
    There is evidence that faecal egg counts of Schistosoma mansoni vary considerably from day to day, which results in poor sensitivity of single stool readings. Intra-specimen variation of S...
  15. pmc Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses
    Jennifer M Fitzpatrick
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    PLoS Negl Trop Dis 3:e543. 2009
    ....
  16. pmc Increases in levels of schistosome-specific immunoglobulin E and CD23(+) B cells in a cohort of Kenyan children undergoing repeated treatment and reinfection with Schistosoma mansoni
    Carla L Black
    Center for Tropical and Emerging Global Diseases and Department of Microbiology, University of Georgia, Athens, Georgia 30602 3799, USA
    J Infect Dis 202:399-405. 2010
    ..We conducted a 2-year longitudinal study to determine whether children infected with Schistosoma mansoni develop protection-related immune responses after treatment with praziquantel and whether the development ..
  17. pmc Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation
    L S Cardoso
    Servico de Imunologia, Hospital Universitario Prof Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil
    Clin Exp Immunol 160:266-74. 2010
    b>Schistosoma mansoni infection has been associated with protection against allergies. The mechanisms underlying this association may involve regulatory cells and cytokines. We evaluated the immune response induced by the S...
  18. ncbi Antiparasitic drugs for paediatrics: systematic review, formulations, pharmacokinetics, safety, efficacy and implications for control
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P O Box, CH 4002 Basel, Switzerland
    Parasitology 138:1620-32. 2011
    ....
  19. ncbi Schistosomiasis
    Bruno Gryseels
    Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerpen, Belgium
    Infect Dis Clin North Am 26:383-97. 2012
    ..Praziquantel is the drug of choice, active against all species in a single or a few oral doses. Current control strategies consist mainly of preventive therapy in communities or groups at risk...
  20. pmc Whole mount in situ hybridization methodology for Schistosoma mansoni
    Alexis A Cogswell
    Rush University Medical Center, Department of Immunology Microbiology, Chicago, IL, United States
    Mol Biochem Parasitol 178:46-50. 2011
    The genome sequence for Schistosoma mansoni has been determined, allowing the complete protein complement to be predicted. However, few functional genomics techniques have been developed for use in S...
  21. ncbi Variations in helminth faecal egg counts in Kato-Katz thick smears and their implications in assessing infection status with Schistosoma mansoni
    Nega Berhe
    Institute of Pathobiology, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    Acta Trop 92:205-12. 2004
    ..7 mg templates. In a subset of 169 subjects who had no demonstrable Schistosoma mansoni eggs in their first three Kato-Katz thick smears, we assessed the comparative advantage of examining an ..
  22. ncbi Schistosoma mansoni worm glycolipids induce an inflammatory phenotype in human dendritic cells by cooperation of TLR4 and DC-SIGN
    Caroline M W van Stijn
    VU University Medical Center, Van den Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Mol Immunol 47:1544-52. 2010
    ..We show here that Schistosoma mansoni worm glycolipids induce DC activation as indicated by upregulation of the maturation markers CD80, CD86 and ..
  23. ncbi Screening the Schistosoma mansoni transcriptome for genes differentially expressed in the schistosomulum stage in search for vaccine candidates
    Leonardo P Farias
    Centro de Biotecnologia, Instituto Butantan, Av Vital Brasil 1500, 05503 900 Sao Paulo, Sao Paulo, Brazil
    Parasitol Res 108:123-35. 2011
    ..attempt to identify genes up-regulated in the schistosomulum stage in relation to cercaria, we explored the Schistosoma mansoni transcriptome by looking at the relative frequency of reads in EST libraries from both stages...
  24. pmc Human U6 promoter drives stronger shRNA activity than its schistosome orthologue in Schistosoma mansoni and human fibrosarcoma cells
    Raphaël Duvoisin
    Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Medical Center, Ross Hall 448, 2300 I Street NW, Washington, DC 20037, USA
    Transgenic Res 21:511-21. 2012
    ..Following transduction of both HT1080 fibrosarcoma cells and schistosomules of Schistosoma mansoni with pseudotyped MLV virions, stronger knockdown of luciferase activity was seen with the virions encoding ..
  25. pmc SchistoDB: a Schistosoma mansoni genome resource
    Adhemar Zerlotini
    Laboratory of Cellular and Molecular Parasitology, Instituto René Rachou Fiocruz, Belo Horizonte, MG, Brazil
    Nucleic Acids Res 37:D579-82. 2009
    SchistoDB (http://schistoDB.net/) is a genomic database for the parasitic organism Schistosoma mansoni, one of the major causative agents of schistosomiasis worldwide. It currently incorporates sequences and annotation for S...
  26. pmc Identification of oxadiazoles as new drug leads for the control of schistosomiasis
    Ahmed A Sayed
    Department of Biological Sciences, Illinois State University, Normal, Illinois 61790, USA
    Nat Med 14:407-12. 2008
    ..The compound was active against the three major schistosome species infecting humans. These protective effects exceed benchmark activity criteria set by the World Health Organization for lead compound development for schistosomiasis...
  27. pmc Biomphalaria glabrata peroxiredoxin: effect of schistosoma mansoni infection on differential gene regulation
    Matty Knight
    Biomedical Research Institute, 12111 Parklawn Drive, Rockville, MD 20852, USA
    Mol Biochem Parasitol 167:20-31. 2009
    ..may be associated with resistance/susceptibility in the intermediate snail host Biomphalaria glabrata to Schistosoma mansoni infection, a snail albumen gland cDNA library was differentially screened and a partial cDNA encoding an ..
  28. ncbi Helminth antigens modulate immune responses in cells from multiple sclerosis patients through TLR2-dependent mechanisms
    Jorge Correale
    Dr Raul Carrea Institute for Neurological Research, Foundation for the Fight against Childhood Neurological Diseases FLENI, Department of Neurology, Buenos Aires, Argentina
    J Immunol 183:5999-6012. 2009
    ..Moreover, cells exposed to TLR2 agonists or to soluble egg Ag (SEA) from Schistosoma mansoni resulted in significant TLR2 up-regulation...
  29. pmc Observed reductions in Schistosoma mansoni transmission from large-scale administration of praziquantel in Uganda: a mathematical modelling study
    Michael D French
    Schistosomiasis Control Initiative, Imperial College London, London, United Kingdom
    PLoS Negl Trop Dis 4:e897. 2010
    ..In this study, a mathematical modelling approach was used to estimate reductions in the rate of Schistosoma mansoni reinfection following annual mass drug administration (MDA) with praziquantel in Uganda over four years (..
  30. pmc Protein variation in blood-dwelling schistosome worms generated by differential splicing of micro-exon gene transcripts
    Ricardo DeMarco
    Department of Biology, University of York, York YO10 5YW, United Kingdom
    Genome Res 20:1112-21. 2010
    b>Schistosoma mansoni is a well-adapted blood-dwelling parasitic helminth, persisting for decades in its human host despite being continually exposed to potential immune attack. Here, we describe in detail micro-exon genes (MEG) in S...
  31. pmc Time series analysis of the transcriptional responses of Biomphalaria glabrata throughout the course of intramolluscan development of Schistosoma mansoni and Echinostoma paraensei
    Patrick C Hanington
    Center for Theoretical and Evolutionary Immunology CETI, Department of Biology, MSC03 2020, 1 University of New Mexico, Albuquerque, NM 87131, USA
    Int J Parasitol 40:819-31. 2010
    ..exposure to two different trematode species to which the snail is susceptible: the medically important Schistosoma mansoni, exemplifying sporocyst production in its larval development, or Echinostoma paraensei, representing an ..
  32. pmc An atlas for Schistosoma mansoni organs and life-cycle stages using cell type-specific markers and confocal microscopy
    James J Collins
    Howard Hughes Medical Institute, Department of Cell and Developmental Biology, Neuroscience Program, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    PLoS Negl Trop Dis 5:e1009. 2011
    ..The methodologies described here will facilitate functional analyses aimed at understanding fundamental biological processes in these parasites...
  33. pmc Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family
    Iain W Chalmers
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    BMC Genomics 9:89. 2008
    ..Proteins containing this domain are implicated in diverse biological activities and may be important for chronic host/parasite interactions...
  34. pmc Rapid assessment of Schistosoma mansoni: the validity, applicability and cost-effectiveness of the Lot Quality Assurance Sampling method in Uganda
    Simon Brooker
    London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 10:647-58. 2005
    ..19 per schoolchild. We conclude that, in Uganda, LQAS provides a rapid, valid and cost-effective method for guiding decision makers in allocating finite resources for the control of schistosomiasis...
  35. pmc Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni
    Kathrin K Geyer
    Institute of Biological, Environmental and Rural Sciences IBERS, Aberystwyth University, Penglais Campus, Aberystwyth SY23 3DA, UK
    Nat Commun 2:424. 2011
    Similar to other metazoan pathogens, Schistosoma mansoni undergoes transcriptional and developmental regulation during its complex lifecycle and host interactions...
  36. ncbi Schistosomiasis and liver fibrosis
    Z A Andrade
    Laboratory of Experimental Pathology, Gonçalo Moniz Research Center FIOCRUZ Salvador, BA, Brazil
    Parasite Immunol 31:656-63. 2009
    b>Schistosoma mansoni infection invariably results in liver fibrosis of the host...
  37. ncbi An anti-atherogenic effect of Schistosoma mansoni infections in mice associated with a parasite-induced lowering of blood total cholesterol
    M J Doenhoff
    School of Biological Sciences, University of Wales Bangor, UK
    Parasitology 125:415-21. 2002
    ..To test whether there may be a causal relationship we examined the effects of Schistosoma mansoni infections in mice that develop cardiovascular pathology as a result of a genetic deficiency in ..
  38. ncbi Mapping fucosylated epitopes on glycoproteins and glycolipids of Schistosoma mansoni cercariae, adult worms and eggs
    M L M Robijn
    Department of Parasitology, Centre of Infectious Diseases, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    Parasitology 130:67-77. 2005
    ..Galbeta1-4(Fucalpha1-3)GlcNAc (Lewis X), and GalNAcbeta1-4(Fucalpha1-2Fucalpha1-3)GlcNAc (LDN-DF) in Schistosoma mansoni cercariae, adult worms and eggs, was surveyed using previously defined anti-carbohydrate monoclonal ..
  39. ncbi Gender-specific expression of complex-type N-glycans in schistosomes
    Manfred Wuhrer
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Glycobiology 16:991-1006. 2006
    Sex-specific gene expression by Schistosoma mansoni worms has been demonstrated at the transcriptome as well as the proteome levels...
  40. pmc Glycotope analysis in miracidia and primary sporocysts of Schistosoma mansoni: differential expression during the miracidium-to-sporocyst transformation
    Nathan A Peterson
    Department of Pathobiological Sciences, University of Wisconsin Madison, School of Veterinary Medicine, 2115 Observatory Drive, Madison, WI 53706, USA
    Int J Parasitol 39:1331-44. 2009
    ..investigate the developmental expression of the following glycotopes in miracidia and primary sporocysts of Schistosoma mansoni: GalNAcbeta1-4GlcNAc (LDN), GalNAcbeta1-4(Fucalpha1-3)GlcNAc (LDN-F), Fucalpha1-3GalNAcbeta1-4GlcNAc (F-LDN)..
  41. pmc Larval excretory-secretory products from the parasite Schistosoma mansoni modulate HSP70 protein expression in defence cells of its snail host, Biomphalaria glabrata
    Zahida Zahoor
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey KT1 2EE, UK
    Cell Stress Chaperones 15:639-50. 2010
    ..This study focused on the effects of larval excretory-secretory products (ESPs) from the parasite Schistosoma mansoni on HSP70 protein expression levels in haemocytes (defence cells) from its snail intermediate host ..
  42. pmc Soil transmitted helminths and schistosoma mansoni infections among school children in Zarima town, northwest Ethiopia
    Abebe Alemu
    Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
    BMC Infect Dis 11:189. 2011
    ..Therefore, the aim of this study was to determine the prevalence and associated risk factors of soil transmitted helminths and intestinal Schistosomiasis...
  43. pmc Characterization of the Src/Abl hybrid kinase SmTK6 of Schistosoma mansoni
    Svenja Beckmann
    Institute for Parasitology, Justus Liebig University Giessen, 35392 Giessen, Germany
    J Biol Chem 286:42325-36. 2011
    ..Syk kinase identified in a parasite and found to be tissue-specifically transcribed in the gonads of adult Schistosoma mansoni. Functional analyses confirmed its role in oogenesis and spermatogenesis...
  44. ncbi Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni
    Matheus de Souza Gomes
    Genetics and Biotechnology Lab, Centre for Chromosome Biology, C306 Aras de Brun, National University of Ireland Galway, Galway, Ireland
    Genomics 98:96-111. 2011
    ..Here, we report the identification of 67 mature and 42 precursor miRNAs in the Schistosoma mansoni parasite. The evolutionarily conserved S...
  45. pmc An in-depth analysis of a piece of shit: distribution of Schistosoma mansoni and hookworm eggs in human stool
    Stefanie J Krauth
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 6:e1969. 2012
    ..We studied the spatial distribution of Schistosoma mansoni and hookworm eggs in stool samples, the effect of homogenization, and determined egg counts over time in ..
  46. pmc Molecular and functional characterization of a tandem-repeat galectin from the freshwater snail Biomphalaria glabrata, intermediate host of the human blood fluke Schistosoma mansoni
    Timothy P Yoshino
    Department of Pathobiological Sciences, School of Veterinary Medicine University, of Wisconsin, Madison, WI 53706, USA
    Gene 411:46-58. 2008
    ..and circulating hemocytes of the snail Biomphalaria glabrata, intermediate host of the human blood fluke Schistosoma mansoni. The predicted B...
  47. pmc Transcriptional changes in Schistosoma mansoni during early schistosomula development and in the presence of erythrocytes
    Geoffrey N Gobert
    Division of Infectious Diseases, Queensland Institute of Medical Research, Queensland, Australia
    PLoS Negl Trop Dis 4:e600. 2010
    ..The newly transformed schistosomulum stage is susceptible to the immune response and is a target for vaccine development and rational drug design...
  48. ncbi Schistosoma mansoni: signal transduction processes during the development of the reproductive organs
    S Beckmann
    Institute for Parasitology, Justus Liebig University, 35392 Giessen, Germany
    Parasitology 137:497-520. 2010
    ..Some of these molecules are also active in the testes of males, probably fulfilling similar roles as in the ovary...
  49. pmc Lack of global dosage compensation in Schistosoma mansoni, a female-heterogametic parasite
    Beatriz Vicoso
    Department of Integrative Biology and Center for Theoretical and Evolutionary Genomics, UC Berkeley, USA
    Genome Biol Evol 3:230-5. 2011
    ..we use published genomic and expression data to test for the presence of global dosage compensation in Schistosoma mansoni, a trematode parasite that causes schistosomiasis in humans...
  50. ncbi Proteomic analysis of Schistosoma mansoni cercarial secretions
    Giselle M Knudsen
    Department of Pathology and the Sandler Center, University of California, San Francisco, California 94143 0446, USA
    Mol Cell Proteomics 4:1862-75. 2005
    ..Identification of proteins secreted by invasive larvae provides important new information for validation of models of skin invasion and immune evasion and aids in rational development of an anti-schistosome vaccine...
  51. pmc Role for a somatically diversified lectin in resistance of an invertebrate to parasite infection
    Patrick C Hanington
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Proc Natl Acad Sci U S A 107:21087-92. 2010
    ..FREP3 is up-regulated in three models of resistance of B. glabrata to infection with Schistosoma mansoni or Echinostoma paraensei, and functions as an opsonin favoring phagocytosis by hemocytes...
  52. pmc Suppressing glucose transporter gene expression in schistosomes impairs parasite feeding and decreases survival in the mammalian host
    Greice Krautz-Peterson
    Molecular Helminthology Laboratory, Division of Infectious Diseases, Department of Biomedical Sciences, Tufts University, Cummings School of Veterinary Medicine, Grafton, Massachusetts, United States of America
    PLoS Pathog 6:e1000932. 2010
    ..These findings provide direct evidence for the importance of SGTP1 and SGTP4 for schistosomes in importing exogenous glucose and show that these proteins are important for normal parasite development in the mammalian host...
  53. pmc RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening
    Sasa Stefanic
    Sandler Center for Drug Discovery, California Institute for Quantitative Biosciences QB3, University of California San Francisco, San Francisco, California, United States of America
    PLoS Negl Trop Dis 4:e850. 2010
    ..Therefore, in the context of standardizing larger RNAi screens, data are limited on the extent of possible off-targeting effects, gene-to-gene variability in RNAi efficiency and the operational capabilities and limits of RNAi...
  54. pmc The tegument of the human parasitic worm Schistosoma mansoni as an excretory organ: the surface aquaporin SmAQP is a lactate transporter
    Zahra Faghiri
    Molecular Helminthology Laboratory, Division of Infectious Diseases, Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, Grafton, Massachusetts, United States of America
    PLoS ONE 5:e10451. 2010
    ..These findings extend the proposed functions of the schistosome tegument beyond its known capacity as an organ of nutrient uptake to include a role in metabolic waste excretion...
  55. pmc Schistosoma mansoni Infections in young children: when are schistosome antigens in urine, eggs in stool and antibodies to eggs first detectable?
    J Russell Stothard
    Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, United Kingdom
    PLoS Negl Trop Dis 5:e938. 2011
    ..In the context of future epidemiological monitoring, we sought to compare the detection thresholds of available diagnostic tools for Schistosoma mansoni and estimate a likely age of first infection for these children.
  56. pmc Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression
    Justin J Taylor
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4539, USA
    J Clin Invest 119:1019-28. 2009
    ..Infections with helminth parasites, such as Schistosoma mansoni, are often chronic and characterized by the development of strong Th2 responses that peak during the acute ..
  57. ncbi Mass spectrometric analysis of the Schistosoma mansoni tegumental sub-proteome
    Bas W M van Balkom
    Department of Biomolecular Mass Spectrometry, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    J Proteome Res 4:958-66. 2005
    b>Schistosoma mansoni is a parasitic worm that lives in the blood vessels of its host. We mapped the S...
  58. ncbi Use of circulating cathodic antigen (CCA) dipsticks for detection of intestinal and urinary schistosomiasis
    J Russell Stothard
    Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK
    Acta Trop 97:219-28. 2006
    ..conditions, the sensitivity (SS) and specificity (SP) of the dipstick was 83 and 81% for detection of Schistosoma mansoni infections while positive predictive (PPV) and negative predictive values (NPV) were 84%...
  59. pmc Culture for genetic manipulation of developmental stages of Schistosoma mansoni
    Victoria H Mann
    Department of Microbiology, Immunology and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
    Parasitology 137:451-62. 2010
    ..Here we review methods to isolate and culture developmental stages of Schistosoma mansoni, including eggs, sporocysts, schistosomules and adults, in particular as these procedures relate to ..
  60. pmc Schistosoma mansoni antigens modulate experimental allergic asthma in a murine model: a major role for CD4+ CD25+ Foxp3+ T cells independent of interleukin-10
    Lucila G G Pacifico
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627, Pampulha, Belo Horizonte, MG, Brazil 31270 901
    Infect Immun 77:98-107. 2009
    ..We investigated whether Schistosoma mansoni infection or injection of parasite eggs can modulate airway allergic inflammation in mice, examining the ..
  61. pmc Successful parasitism of vector snail Biomphalaria glabrata by the human blood fluke (trematode) Schistosoma mansoni: a 2009 assessment
    Christopher J Bayne
    Department of Zoology, Oregon State University, Corvallis, OR 97331, USA
    Mol Biochem Parasitol 165:8-18. 2009
    ..An approach targeting genes involved in relevant pathways has been fruitful in the Schistosoma mansoni -- B...
  62. pmc Schistosoma mansoni U6 gene promoter-driven short hairpin RNA induces RNA interference in human fibrosarcoma cells and schistosomules
    Mary A Ayuk
    Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Medical Center, 2300 I Street, NW, Washington, DC 20037, USA
    Int J Parasitol 41:783-9. 2011
    ..To develop a vector-based RNAi model for Schistosoma mansoni, the schistosome U6 gene promoter was employed to drive expression of shRNA targeting reporter firefly ..
  63. pmc The Syk kinase SmTK4 of Schistosoma mansoni is involved in the regulation of spermatogenesis and oogenesis
    Svenja Beckmann
    Institute for Parasitology, Justus Liebig University, Giessen, Germany
    PLoS Pathog 6:e1000769. 2010
    The signal transduction protein SmTK4 from Schistosoma mansoni belongs to the family of Syk kinases. In vertebrates, Syk kinases are known to play specialized roles in signaling pathways in cells of the hematopoietic system...
  64. pmc Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages
    Sheila Donnelly
    Level 6, Bldg 4, University of Technology Sydney, Cnr Thomas and Harris St, Ultimo, Sydney, NSW 2007, Australia
    FASEB J 22:4022-32. 2008
    ..Using murine models for the helminth infections caused by Fasciola hepatica (Fh) and Schistosoma mansoni (Sm), we show that a secreted antioxidant, peroxiredoxin (Prx), induces alternative activation of ..
  65. pmc Geographical distribution of intestinal schistosomiasis and soil-transmitted helminthiasis and preventive chemotherapy strategies in Sierra Leone
    Joseph B Koroma
    National Onchocerciasis Control Program, Ministry for Health and Sanitation, Freetown, Sierra Leone
    PLoS Negl Trop Dis 4:e891. 2010
    ....
  66. ncbi Conservation of epidermal growth factor receptor function in the human parasitic helminth Schistosoma mansoni
    Jerome Vicogne
    Unité 547 INSERM, Institut Pasteur de Lille, 59019 Lille Cedex, France
    J Biol Chem 279:37407-14. 2004
    ..functional characterization of SER, the EGF-R-like molecule previously identified in the helminth parasite Schistosoma mansoni. Transactivation assays performed in epithelial Madin-Darby canine kidney cells co-transfected with SER and ..
  67. ncbi Increases in human T helper 2 cytokine responses to Schistosoma mansoni worm and worm-tegument antigens are induced by treatment with praziquantel
    Sarah Joseph
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Infect Dis 190:835-42. 2004
    Levels of Schistosoma mansoni-induced interleukin (IL)-4 and IL-5 and posttreatment levels of immunoglobulin E recognizing the parasite's tegument (Teg) correlate with human resistance to subsequent reinfection after treatment...
  68. ncbi The immunobiology of schistosomiasis
    Edward J Pearce
    Department of Pathobiology, University of Pennsylvania, Philadelphia, Philadelphia 19104 6008, USA
    Nat Rev Immunol 2:499-511. 2002
    ..Here, we attempt to summarize advances in our understanding of the immunology of schistosomiasis, with the bulk of the review reflecting the experimental focus on Schistosoma mansoni infection in mice.
  69. pmc Exposure to malaria affects the regression of hepatosplenomegaly after treatment for Schistosoma mansoni infection in Kenyan children
    Mark Booth
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    BMC Med 2:36. 2004
    b>Schistosoma mansoni and malaria infections are often endemic in the same communities in sub-Saharan Africa, and both have pathological effects on the liver and the spleen. Hepatosplenomegaly associated with S...
  70. pmc TGF-beta signaling controls embryo development in the parasitic flatworm Schistosoma mansoni
    Tori C Freitas
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 3:e52. 2007
    ..Here, we describe a novel parasite-encoded TGF-beta superfamily member, Schistosoma mansoni Inhibin/Activin (SmInAct), which is key to this process...
  71. pmc Differential transcriptomic responses of Biomphalaria glabrata (Gastropoda, Mollusca) to bacteria and metazoan parasites, Schistosoma mansoni and Echinostoma paraensei (Digenea, Platyhelminthes)
    Coen M Adema
    Center for Evolutionary and Theoretical Immunology, Biology MSC03 2020, 1 University of New Mexico, Albuquerque, NM 87131, USA
    Mol Immunol 47:849-60. 2010
    ..Escherichia coli and Micrococcus luteus, respectively), or infection with compatible trematode parasites (Schistosoma mansoni or Echinostoma paraensei, 20 miracidia/snail), relative to controls, using universal reference RNA...
  72. ncbi Evolutionary relationships and biogeography of Biomphalaria (Gastropoda: Planorbidae) with implications regarding its role as host of the human bloodfluke, Schistosoma mansoni
    R J DeJong
    Department of Biology, University of New Mexico, Albuquerque 87131, USA
    Mol Biol Evol 18:2225-39. 2001
    The wide geographic distribution of Schistosoma mansoni, a digenetic trematode and parasite of humans, is determined by the occurrence of its intermediate hosts, freshwater snails of the genus Biomphalaria (Preston 1910)...
  73. pmc T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment
    Kanji Watanabe
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602 3799, USA
    Am J Trop Med Hyg 77:676-82. 2007
    ..Experimental Schistosoma mansoni infection is associated with immunoregulatory mechanisms, including T regulatory cells (Treg) that may help ..
  74. pmc Proteomic analysis of skin invasion by blood fluke larvae
    Elizabeth Hansell
    Sandler Center, California Institute for Quantitative Biosciences QB3, University of California, San Francisco, California, United States of America
    PLoS Negl Trop Dis 2:e262. 2008
    ..To better understand the pathobiology of this initial event in schistosome infection, a proteome analysis of human skin was carried out following invasion by cercariae of Schistosoma mansoni.
  75. pmc Schistosoma mansoni tegument protein Sm29 is able to induce a Th1-type of immune response and protection against parasite infection
    Fernanda C Cardoso
    Departamento de Bioquímica e Imunologia do Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    PLoS Negl Trop Dis 2:e308. 2008
    ..results have recently been obtained using membrane-spanning protein antigens from the tegument of Schistosoma mansoni. Our group recently identified Sm29, another antigen that is present at the adult worm tegument surface...
  76. pmc A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni
    Conor R Caffrey
    Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 4:e4413. 2009
    ..of drug discovery we have taken a comparative chemogenomics approach utilizing the putative proteome of Schistosoma mansoni compared to the proteomes of two model organisms, the nematode, Caenorhabditis elegans and the fruitfly, ..
  77. pmc Retnla (relmalpha/fizz1) suppresses helminth-induced Th2-type immunity
    John T Pesce
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 5:e1000393. 2009
    ..Pulmonary granuloma formation induced by the eggs of the helminth parasite Schistosoma mansoni is dependent on IL-4 and IL-13 and associated with marked increases in Retnla expression...
  78. ncbi The role of chemokines in controlling granulomatous inflammation in Schistosoma mansoni infection
    Patrícia R S Souza
    Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais UFMG, 31270 901 Av Antonio Carlos, 6627 Belo Horizonte, Brazil
    Acta Trop 108:135-8. 2008
    ..The role of chemokines and their receptors in mediating granulomatous inflammation induced by Schistosoma mansoni egg antigens presented in particulate manner have been studied in detail...
  79. pmc Genetic consequences of mass human chemotherapy for Schistosoma mansoni: population structure pre- and post-praziquantel treatment in Tanzania
    Alice J Norton
    Department of Infectious Disease Epidemiology, Imperial College, Faculty of Medicine, London, United Kingdom
    Am J Trop Med Hyg 83:951-7. 2010
    ..round of MDA produced a genetic bottleneck with reductions in a range of measures of genetic diversity of Schistosoma mansoni. Phylogenetic analyses and indices of population differentiation indicated that schistosomes collected in ..
  80. ncbi Vector-based RNA interference of cathepsin B1 in Schistosoma mansoni
    Elissaveta B Tchoubrieva
    Centre for Animal Biotechnology, Faculty of Veterinary Science, The University of Melbourne, Parkville, Vic, 3052, Australia
    Cell Mol Life Sci 67:3739-48. 2010
    ..We recently reported the use of pseudotyped Moloney murine leukaemia virus to accomplish transformation of Schistosoma mansoni. Here, we report the design of a viral vector expressing a dsRNA hairpin to silence expression of the ..
  81. pmc Gene Atlasing of digestive and reproductive tissues in Schistosoma mansoni
    Sujeevi S K Nawaratna
    Queensland Institute of Medical Research, Herston, Australia
    PLoS Negl Trop Dis 5:e1043. 2011
    While considerable genomic and transcriptomic data are available for Schistosoma mansoni, many of its genes lack significant annotation...
  82. pmc Adult somatic stem cells in the human parasite Schistosoma mansoni
    James J Collins
    Howard Hughes Medical Institute and Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Nature 494:476-9. 2013
    ..Here we describe a population of neoblast-like cells in the trematode Schistosoma mansoni. These cells resemble planarian neoblasts morphologically and share their ability to proliferate and ..
  83. pmc The repertoire of G protein-coupled receptors in the human parasite Schistosoma mansoni and the model organism Schmidtea mediterranea
    Mostafa Zamanian
    Department of Biomedical Sciences, Iowa State University, Ames, IA, USA
    BMC Genomics 12:596. 2011
    ..The recent availability of genomic data for the human blood fluke Schistosoma mansoni and the model planarian Schmidtea mediterranea paves the way for the first comprehensive effort to identify ..
  84. ncbi Cloning and sequencing of an hsp70 gene of Schistosoma mansoni
    S Neumann
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    Mol Biochem Parasitol 56:357-60. 1992
    ..To approach this issue we have isolated from Schistosoma mansoni a genomic clone containing the complete coding region of hsp70 and the 5' flanking DNA with transcription ..
  85. pmc Enzymatic shaving of the tegument surface of live schistosomes for proteomic analysis: a rational approach to select vaccine candidates
    William Castro-Borges
    Department of Biology, University of York, Heslington, York, United Kingdom
    PLoS Negl Trop Dis 5:e993. 2011
    The membrane-associated and membrane-spanning constituents of the Schistosoma mansoni tegument surface, the parasite's principal interface with the host bloodstream, have recently been characterized using proteomic techniques...
  86. pmc Identification of immediate response genes dominantly expressed in juvenile resistant and susceptible Biomphalaria glabrata snails upon exposure to Schistosoma mansoni
    Wannaporn Ittiprasert
    Biomedical Research Institute, Rockville, MD 20852, USA
    Mol Biochem Parasitol 169:27-39. 2010
    Resistance or susceptibility of the snail host Biomphalaria glabrata to Schistosoma mansoni is determined by the genetics of both the snail and parasite...
  87. pmc Imaging schistosomes in vivo
    Greice Krautz-Peterson
    Department of Biomedical Sciences, Tufts University, Cummings School of Veterinary Medicine, 200 Westboro Rd, North Grafton, MA 01536, USA
    FASEB J 23:2673-80. 2009
    ..There is a strong positive correlation between the signal detected and parasite number. Schistosoma mansoni parasites of both sexes recovered from infected experimental animals exhibit vivid fluorescence throughout ..
  88. pmc Schistosoma mansoni infection of juvenile Biomphalaria glabrata induces a differential stress response between resistant and susceptible snails
    Wannaporn Ittiprasert
    Biomedical Research Institute, Rockville, MD 20852, USA
    Exp Parasitol 123:203-11. 2009
    ..from resistant (BS-90), non-susceptible (LAC2) and susceptible (NMRI) juvenile Biomphalaria glabrata to Schistosoma mansoni revealed that stress-related genes, heat shock protein 70 (Hsp 70) and reverse transcriptase (RT), were ..
  89. ncbi Schistosoma mansoni Polo-like kinase 1: A mitotic kinase with key functions in parasite reproduction
    Thavy Long
    CIIL Center for Infection and Immunity of Lille Inserm U1019 CNRS UMR 8204, University Lille Nord de France, Institut Pasteur de Lille, 59019 Lille Cedex, France
    Int J Parasitol 40:1075-86. 2010
    ..This work presents the characterisation of the Plk1 homologue (SmPlk1) of Schistosoma mansoni, a trematode responsible for schistosomiasis, one of the most important parasitic diseases, second only to ..
  90. pmc The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti
    Katerina Dolecková
    Department of Parasitology, Faculty of Science, Charles University in Prague, Vinicna 7, 12844 Prague 2, Czech Republic
    Int J Parasitol 39:201-11. 2009
    ..enzyme was named TrCB2 due to its 77% sequence similarity to cathepsin B2 from the important human parasite Schistosoma mansoni. The zymogen was expressed in the methylotropic yeast Pichia pastoris; procathepsin B2 underwent self-..
  91. ncbi Histamine signalling in Schistosoma mansoni: immunolocalisation and characterisation of a new histamine-responsive receptor (SmGPR-2)
    Fouad El-Shehabi
    Institute of Parasitology, McGill University, Macdonald Campus, 21, 111 Lakeshore Road, Ste Anne de Bellevue, Quebec, Canada H9X 3V9
    Int J Parasitol 40:1395-406. 2010
    In parasitic platyhelminthes, including Schistosoma mansoni, biogenic amines play several important roles in the control of motility, metabolism and reproduction. A bioinformatics analysis of the S...
  92. ncbi Immunopathogenesis of schistosomiasis
    Thomas A Wynn
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Immunol Rev 201:156-67. 2004
    ..mansoni infection, and succumb to the disease at an accelerated rate; thus, identifying the 'decoy' IL-13 receptor as a critical life sustaining 'off' switch for tissue damaging egg-induced inflammation...
  93. ncbi Th2 immune response against Schistosoma mansoni infection
    Gabriele Schramm
    Cellular Allergology, Research Center Borstel, Parkallee 22, D 23845, Borstel, Germany
    Microbes Infect 12:881-8. 2010
    b>Schistosoma mansoni eggs - or more specifically, secreted products thereof - are potent inducers of a Th2 response in the host...
  94. ncbi A functionally atypical amidating enzyme from the human parasite Schistosoma mansoni
    Gunnar R Mair
    Parasitology Research Group, School of Biology and Biochemistry, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    FASEB J 18:114-21. 2004
    ..We identified a cDNA encoding PHM in the human parasite Schistosoma mansoni. Transient expression of schistosome PHM (smPHM) revealed functional properties that are different from ..
  95. ncbi Recent advances in vaccine research against schistosomiasis in Brazil
    Sergio C Oliveira
    Department of Biochemistry and Immunology, Institute for Investigation in Immunology Millennium Institute, Federal University of Minas Gerais, Av Antonio Carlos 6627, Pampulha, Belo Horizonte, MG 30161 970, Brazil
    Acta Trop 108:256-62. 2008
    ..than successes, encouraging results have been obtained in recent years using defined recombinant derived Schistosoma mansoni antigens. This article primarily reviews the progress in the development of a vaccine against S...
  96. ncbi Structural characterization of N-glycans from the freshwater snail Biomphalaria glabrata cross-reacting with Schistosoma mansoni glycoconjugates
    Tobias Lehr
    Institute of Biochemistry, Faculty of Medicine, University of Giessen, Friedrichstrasse 24, D 35392 Giessen, Germany
    Glycobiology 17:82-103. 2007
    The human parasitic trematode Schistosoma mansoni has a complex life cycle that includes the freshwater snail Biomphalaria glabrata as intermediate host...
  97. pmc Fluorescent imaging of antigen released by a skin-invading helminth reveals differential uptake and activation profiles by antigen presenting cells
    Ross A Paveley
    Department of Biology, The University of York, York, United Kingdom
    PLoS Negl Trop Dis 3:e528. 2009
    Infection of the mammalian host by the parasitic helminth Schistosoma mansoni is accompanied by the release of excretory/secretory molecules (ES) from cercariae which aid penetration of the skin...
  98. pmc Developmental expression analysis and immunolocalization of a biogenic amine receptor in Schistosoma mansoni
    Fouad El-Shehabi
    Institute of Parasitology, McGill University, Macdonald Campus, 21, 111 Lakeshore Road, Ste Anne de Bellevue, Quebec, Canada H9X 3V9
    Exp Parasitol 122:17-27. 2009
    A Schistosoma mansoni G-protein coupled receptor (SmGPCR) was previously cloned and shown to be activated by the biogenic amine, histamine...
  99. ncbi The effect of Nigella sativa oil against the liver damage induced by Schistosoma mansoni infection in mice
    M R Mahmoud
    Department of Pharmacology, Theodor Bilharz Research Institute, Imbaba, Giza, Egypt
    J Ethnopharmacol 79:1-11. 2002
    ..mansoni infection, an effect which may be induced partly by improving the immunological host system and to some extent with its antioxidant effect...
  100. ncbi Protein kinase C signalling during miracidium to mother sporocyst development in the helminth parasite, Schistosoma mansoni
    Marthe H R Ludtmann
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey KT1 2EE, UK
    Int J Parasitol 39:1223-33. 2009
    ..to this process, the phosphorylation (activation) of protein kinase C (PKC) in larval stages of Schistosoma mansoni undergoing in vitro transformation was explored. Mining of the S. mansoni genomic database revealed two S...
  101. ncbi Organization of the musculature of schistosome cercariae
    G R Mair
    Parasitology Research Group, School of Biology and Biochemistry, Medical Biology Centre, Queen s University Belfast, Belfast BT9 7BL, UK
    J Parasitol 89:623-5. 2003
    ..isothiocyanate staining of filamentous actin was used to identify muscle systems within the cercariae of Schistosoma mansoni. Examination of labeled cercariae by confocal scanning laser microscopy revealed distinct organizational ..

Research Grants62

  1. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2011
    ..b>Schistosoma mansoni is a major human pathogen affecting 108 people worldwide that causes fibrotic granulomatous inflammation in ..
  2. CHEMOKINE RECEPTOR DYNAMICS IN GRANULOMA FORMATION
    Stephen W Chensue; Fiscal Year: 2013
    ..Mycobacterium tuberculosis and Schistosoma mansoni represent epidemic pathogens for which vaccine development has been difficult to achieve...
  3. Cholinergic Receptors as Targets for Accelerated Anthelmintic Discovery
    MICHAEL JOHN KIMBER; Fiscal Year: 2013
    ..malayi and the parasitic flatworm Schistosoma mansoni. The first phase of the project will take place in the academic laboratories and will show that drugs ..
  4. Understanding the biology of schistosomes in response to praziquantel
    Charles Cunningham; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Schistosoma mansoni is one of the most common etiological agents of human schistosomiasis and is estimated to infect more than 83 million humans in 54 countries...
  5. Functional impact of IL33 polymorphisms on asthma &other Th2-mediated diseases
    Kathleen C Barnes; Fiscal Year: 2013
    ..e., Schistosoma mansoni). Many genes have been associated with asthma, but to date very few have replicated...
  6. Evo-epidemiology of Scistosoma mansoni in children in Kenya
    ERIC SAMUEL LOKER; Fiscal Year: 2010
    ..Gerald Mkoji, as an extension of NIH application R01 AI044913 entitled "Evo-epidemiology of Schistosoma mansoni in western Kenya" for which Eric S. Loker, University of New Mexico, serves as PI...
  7. Infectious Disease Genomics and Bioinformatics Training in Brazil
    Jessica C Kissinger; Fiscal Year: 2013
    ..These organisms include: Plasmodium sp., Trypanosoma cruzi. Toxoplasma gondii, Schistosoma mansoni. Anopheles, Blomphalaria and Humans...
  8. Molecular Genetic Tools for Parasitic Helminths
    Edward J Pearce; Fiscal Year: 2013
    ..We will focus on two important human pathogens, Strongyloides stercoralis and Schistosoma mansoni. These represent, respectively, the Nematoda and Platyhelminthes, two phyla of medically important ..
  9. Regulation of vitamin A metabolism during Schistosoma mansoni infection
    PNG LOKE; Fiscal Year: 2013
    Helminths such as Schistosoma mansoni are remarkably efficient at establishing chronic infections with limited inflammatory pathology in some of their hosts, while in other infected people they can cause severe morbidity and they are a ..
  10. Recruitment of CX3CR1-GFP+ monocytes during Schistosoma mansoni infection.
    PNG LOKE; Fiscal Year: 2012
    ..The goal of this project is to identify where these macrophages come from in order to design interventional strategies that could help regulate the inflammatory process during a type 2 response. ..
  11. Asb2 in CD4+ T cell lineage differentiation and its plasticity
    Xiao Hong Sun; Fiscal Year: 2013
    ..vivo by immunizing wild type and Asb2-/- mice with a parasite antigen, the soluble egg antigen (SEA) from Schistosoma mansoni or with OVA in alum...
  12. Characterization of CCR5-like Molecules in Leishmania
    Lynn Soong; Fiscal Year: 2010
    ..cytokines/chemokines and their receptors by many pathogens, including DNA viruses, Toxoplasma gondii, and Schistosoma mansoni, such mimicry has not been identified for trypanosomatids...
  13. Exploring statins as a small molecule therapy for treatment of schistosomiasis
    Conor Caffrey; Fiscal Year: 2013
    ..Secondly, we will optimize and standardize the recombinant expression of active Schistosoma mansoni HMGR, which will be central to deriving the kinetic and crystallographic data necessary to prosecute a ..
  14. Modeling Drug Induced Resistance in S. mansoni Endemic Areas
    Rodrigo Correa-Oliveira; Fiscal Year: 2013
    ..provided by applicant): This TMRC presents an innovative approach to understand host-parasite dynamics of Schistosoma mansoni infection in an endemic population in Brazil...
  15. IMMUNOBIOLOGY OF SCHISTOSOME-MOLLUSC INTERACTIONS
    Timothy P Yoshino; Fiscal Year: 2013
    ..of inbred strains of the snail Biomphalaria glabrata to infection by larvae of the human blood fluke Schistosoma mansoni, causative agent of hepatosplenic schistosomiasis...
  16. Determinants of resistance in human schistosomiasis
    Daniel G Colley; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Infection with Schistosoma mansoni remains a major public health problem in much of Africa, and it is now clear that chronic schistosome infections can lead to both severe and subtle morbidity...
  17. Role of a schistosome cysteine protease in Th response polarization
    Stephen J Davies; Fiscal Year: 2013
    ..We recently demonstrated that Schistosoma mansoni cathepsin B1 (SmCB1), a major secreted cysteine protease of S...
  18. Genetic Analysis of Host Specificity in Schistosoma mansoni
    Tim J Anderson; Fiscal Year: 2013
    ..In Schistosoma mansoni, one of three medically important schistosome species infecting humans, elegant experimental work ..
  19. UNDERLYING MECHANISMS OF SCHISTOSOME/SNAIL COMPATIBILITY
    CHRISTOPHER JEFFREY BAYNE; Fiscal Year: 2012
    ..glabrata snails with known susceptible or resistant phenotypes to a standard strain (Oregon PR1) of Schistosoma mansoni, a causative agent of human intestinal schistosomiasis...
  20. Immunoregulation of Schistosomiasis
    Miguel J Stadecker; Fiscal Year: 2013
    ..This results in granulomatous and fibrosing inflammation, which in the case of the species Schistosoma mansoni, takes place in the liver and intestines...
  21. PRODUCT DEVELOPMENT OF A MEMBRANE TETRASPANIN VACCINE AGAINST SCHISTOSOMIASIS
    CHARLES RUSSELL MIDDAUGH; Fiscal Year: 2011
    ..From this analysis a tetrapanin surface antigen from Schistosoma mansoni and known as Sm-TSP-2 has emerged...
  22. Efficient Linkage Mapping Methods for Schistosoma mansoni
    Philip T LoVerde; Fiscal Year: 2013
    ..for Oxamniquine resistance on chr 6 providing proof-of-principal that linkage mapping is also feasible for Schistosoma mansoni. However, classical linkage mapping is extremely labor intensive, logistically challenging and expensive, ..
  23. Schistosomiasis Associated Pulmonary Arterial Hypertension
    BRIAN BARKLEY GRAHAM; Fiscal Year: 2013
    ..Our overall research goal is to elucidate how the host response to Schistosoma mansoni results in PAH...
  24. Role of TGF-beta in Schistosoma mansoni
    Tori Freitas; Fiscal Year: 2009
    ..b>Schistosoma mansoni debilitates millions of people with no vaccine available and only one drug at hand for treating the disease...
  25. Developing comparative and functional genomic approaches to study Schistosoma
    Phillip A Newmark; Fiscal Year: 2013
    ..in situ hybridization to compare the tissue-specific expression of 108 flatworm-specific genes in Schistosoma mansoni and S. mediterranea. We will also determine the loss-of-function phenotype for these genes in S...
  26. Understanding the biology of schistosomes in response to praziquantel
    Charles Cunningham; Fiscal Year: 2010
    ..We will exploit the fact that different life cycle stages of Schistosoma mansoni have differing susceptibilities to PZQ by employing microarrays to analyze the transcriptomes of miracidia, ..
  27. Macrophage Differentiation in Acute and Chronic Helminth Infection.
    Natasha M Girgis; Fiscal Year: 2013
    ..We propose to use infection with the parasitic helminth Schistosoma mansoni as a model of both acute and chronic Th2 infection to examine the origins and mechanisms of differentiation ..
  28. Snail-Related Studies of Transmission and Control of Schistosomiasis in Kenya
    ERIC SAMUEL LOKER; Fiscal Year: 2013
    ..victims of schistosomiasis live in sub-Saharan Africa, with one of the most prominent causal species being Schistosoma mansoni. This proposal focuses on the interactions between S...
  29. PARASITIC CASTRATION IN SNAILS--ROLE OF BIOGENIC AMINES
    TIMOTHY YOSHINO; Fiscal Year: 1999
    ..However, the molecular basis for this phenomenon is still unknown. Preliminary findings show that Schistosoma mansoni infection of the snail Biomphalaria glabrata leads to a depression in oviposition and concurrently in the ..
  30. Development of a functional genomics toolbox for schistosome parasites
    DAVID LEE WILLIAMS; Fiscal Year: 2013
    ..Although the genome sequences of Schistosoma mansoni and S. japonicum have been determined, most predicted genes encode proteins with unknown function...
  31. The role of the vascular endothelium in schistosomiasis
    Melissa Beall; Fiscal Year: 2002
    ..Previous studies suggest that Schistosoma mansoni requires host-derived factors for normal development and sexual maturation...
  32. IDENTIFICATION OF NATURALLY PROCESSED SMANSONI PEPTIDES
    Philip Loverde; Fiscal Year: 2001
    Schistosomiasis, a debilitating disease caused by Schistosoma mansoni, is estimated to affect 200-300 million people worldwide...
  33. Induction of Pathogenic Innate and Adaptive Immune Responses by Schistosome Helmi
    MARA SHAINHEIT; Fiscal Year: 2009
    ..granulomatous inflammatory reaction against parasite eggs, which in the case of infection with Schistosoma mansoni, primarily takes place in the liver and intestines...
  34. BIOLOGY OF TREMATODE-SNAIL ASSOCIATIONS
    ERIC SAMUEL LOKER; Fiscal Year: 2010
    ..goal of this project is to better understand the biology of snail-borne helminth parasites such as Schistosoma mansoni that continue to impose a significant burden or. 'human health in much of the developing world...
  35. Dynamics of SHIV clade C and S mansoni coinfection
    Ruth Ruprecht; Fiscal Year: 2005
    ..model studies have shown that vaccines that normally induce strong cellular immunity failed to do so in Schistosoma mansoni-infected animals...
  36. PURINE METABOLISM IN SCHISTOSOMA MANSONI
    C Wang; Fiscal Year: 1991
    ..We have recently verified the absence of de novo synthesis of purine nucleotides in Schistosoma mansoni and proceeded to delineate the purine salvage pathways in this organism...
  37. SCHISTOSOME RECEPTOR SERINE/THRENONINE KINASE
    Edward Pearce; Fiscal Year: 1999
    The long term objective of this proposal is to elucidate the function of the Schistosoma mansoni surface membrane serine/threonine kinase...
  38. GEOGRAPHIC INFORMATION SYSTEMS & SCHISTOSOMIASIS
    John Malone; Fiscal Year: 2000
    ..The "Climate Based Parasite Forecast System" previously developed for Fasciola will be adapted for Schistosoma mansoni and S...
  39. TRANS-SPLICING IN PARASITIC FLATWORMS
    Richard Davis; Fiscal Year: 1992
    ..The applicant has shown that a subset of mRNAs in Schistosoma mansoni contain a 36-nucleotide spliced leader (SL) at their 5' termini...
  40. Role of IL-4 During Acute Schistosomiasis
    Elisabeth Patton; Fiscal Year: 2002
    DESCRIPTION (adapted from applicant's abstract): Schistosoma mansoni is a parasitic helminth of significant public health concern. Clinical disease is due to the granulomatous response to eggs that become trapped in the liver...
  41. SCHISTOSOME NUCLEAR PROTEIN FUNCTION AND REGULATION
    James Tracy; Fiscal Year: 2000
    ..Most cells of adult Schistosoma mansoni are quiescent. The principal exceptions are the reproductive organs, especially the female vitelline glands...
  42. IMMUNOLOGIC RESPONSES TO SCHISTOSOMA MANSONI
    DANIEL COLLEY; Fiscal Year: 1992
    ..These settings parallel schistosomiasis in the sense that in each the body's immune system must "learn" to deal with chronic antigenic exposure...
  43. CUTANEOUS IMMUNE RESPONSE TO PARASITIC INFECTION
    Ramaswamy Kalyanasundaram; Fiscal Year: 2000
    ..this proposal is to identify the potential role of skin in initiating a protective immune response against Schistosoma mansoni infection in human and mice. The skin is the only site of entry for this parasite into human...
  44. POPULATION STRUCTURE OF SCHISTOSOMES AND HOST SNAILS
    DENNIS MINCHELLA; Fiscal Year: 2003
    ..The recent characterization of microsatellite markers for Schistosoma mansoni and Biomphalaria glabrata provides an opportunity to study population structure of both host and parasite ..
  45. GLYCOPROTEIN OLIGOSACCHARIDES OF SCHISTOSOMA MANSONI
    Richard Cummings; Fiscal Year: 1990
    b>Schistosoma mansoni is one of the three major parasitic blood flukes and causes a hepatosplenic disease in humans. Glycoproteins from S...
  46. Schistosoma mansoni resistance to Praziquantel treatment
    DENNIS MINCHELLA; Fiscal Year: 2007
    Schistosomiasis is caused by parasites of the Schistosoma genus, and Schistosoma mansoni is the only species found in South America. The disease causes significant human morbidity and mortality in endemic areas worldwide...
  47. POPULATION STRUCTURE OF SCHISTOSOMES AND HOST SNAILS
    DENNIS MINCHELLA; Fiscal Year: 2007
    ..The recent characterization of allelic microsatellite markers for Schistosoma mansoni and Biomphalaria glabrata provides us with an opportunity to study population structure of both parasite ..
  48. DESIGN OF CHEMOTHERAPEUTIC AGENTS
    Paul Talalay; Fiscal Year: 1980
    ..specific emphasis on the development of safe and effective agents for mass treatment of infections with Schistosoma mansoni and Schistosoma japonicum...
  49. SEQUENCING 12 MB OF THE SCHISTOSOMA MANSONI GENOME
    Najib El Sayed; Fiscal Year: 2002
    DESCRIPTION (Investigator's Abstract): Schistosoma mansoni is a trematode parasite that causes schistosomiasis...
  50. GRANULOMATOUS INFLAMMATION AND INTERLEUKIN-2
    Daniel Remick; Fiscal Year: 1990
    ..will use a well-characterized model of T-cell-mediated synchronous granulomas, induced by embolization of Schistosoma mansoni eggs to the pulmonary vasculature...
  51. SCHISTOSOME-SNAIL COMPATIBILITY: UNDERLYING MECHANISMS
    Christopher Bayne; Fiscal Year: 1991
    ..to understand the cellular and molecular mechanisms which result in transmission of the human blood fluke Schistosoma mansoni in certain individual host snails (Biomphalaria glabrata), and the failure of transmission in others...
  52. SNAIL/SCHISTOSOME GENETIC INFLUENCES ON CERCARIOGENESIS
    Fred Lewis; Fiscal Year: 2002
    ..to identify the relevant Biomphalaria glabrata snail genes involved in resistance/susceptibility to Schistosoma mansoni, to determine their chromosomal location, and to identify developmentally regulated transcripts after ..
  53. SCHISTOSOMIASIS RESEARCH REAGENT RESOURCE CENTER
    Fred A Lewis; Fiscal Year: 2010
    ..life cycles and distribute infected animals and intermediate hosts of the three human schistosome species (Schistosoma mansoni, S. haematobium, and S...
  54. SCHISTOSOMIASIS RESEARCH REAGENT RESOURCE CENTER
    Fred A Lewis; Fiscal Year: 2009
    ..life cycles and distribute infected animals and intermediate hosts of the three human schistosome species (Schistosoma mansoni, S. haematobium, and S...
  55. BIOCHEMISTRY OF SCHISTOSOME GLUTATHIONE S-TRANSFERASES
    James Tracy; Fiscal Year: 1991
    ..Adult Schistosoma mansoni contain five cytosolic glutathione S- transferases, three of which have similar properties...
  56. Immunity of Schistosome Glycoconjugates
    Richard Cummings; Fiscal Year: 2007
    Animals and humans infected with the bloodfluke Schistosoma mansoni generate specific immune responses to glycan antigens...
  57. Effect of Schistosoma Co-infection on HIV Immune Responses
    Huyen Cao; Fiscal Year: 2007
    ..It has been proposed that chronic Schistosoma mansoni (S...
  58. ELECTRON MICROSCOPE
    WILLARD GRANATH; Fiscal Year: 1991
    ..b>Schistosoma mansoni, and one of its' major intermediate hosts. Biomphalaria glabrata. 2...
  59. Immune evasion by the human blood fluke Schistosoma man*
    John Hay; Fiscal Year: 2005
    ..Zvi Fishelson and Daniel Gold as an extension of NIH grant # R01AI46762. The blood fluke Schistosoma mansoni causes intestinal schistosomiasis, a parasitic disease affecting the lives of millions throughout Africa ..
  60. SNAIL/SCHISTOSOME GENETIC INFLUENCES ON CERCARIOGENESIS
    Fred Lewis; Fiscal Year: 1991
    ..This research will use genetically well- characterized Biomphalaria glabrata stocks and Schistosoma mansoni strains...
  61. C-C CHEMOKINES AND EOSINOPHIL AIRWAY INFLAMMATION
    Nicholas Lukacs; Fiscal Year: 2000
    ..murine model of eosinophilic airway inflammation will be generated using an established model of Schistosoma mansoni egg antigen (SEA)-induced Th2-type hypereosinophilic response localized to the airway with airway ..
  62. BIOGENESIS OF SURFACE MEMBRANE OF SCHISTOSOMA MANSONI
    PETER WIEST; Fiscal Year: 1992
    ..Second, a research project on the biology of surface maturation of Schistosoma mansoni will be initiated under Drs. Kenneth Miller and G. Richard Olds of Brown University...