fasciola hepatica

Summary

Summary: A species of helminth commonly called the sheep liver fluke. It occurs in the biliary passages, liver, and gallbladder during various stages of development. Snails and aquatic vegetation are the intermediate hosts. Occasionally seen in man, it is most common in sheep and cattle.

Top Publications

  1. ncbi An ultrasensitive capture ELISA for detection of Fasciola hepatica coproantigens in sheep and cattle using a new monoclonal antibody (MM3)
    Mercedes Mezo
    Centro de Investigaciones Agrarias, Mabegondo, PO Box 10, 15080 A Coruña, Spain
    J Parasitol 90:845-52. 2004
  2. pmc Liver fluke induces cholangiocarcinoma
    Banchob Sripa
    Department of Pathology, Khon Kaen University, Khon Kaen, Thailand
    PLoS Med 4:e201. 2007
  3. ncbi Elucidating the transcriptome of Fasciola hepatica - a key to fundamental and biotechnological discoveries for a neglected parasite
    Neil D Young
    Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia
    Biotechnol Adv 28:222-31. 2010
  4. pmc An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: proteins associated with invasion and infection of the mammalian host
    Mark W Robinson
    Institute for the Biotechnology of Infectious Diseases, University of Technology Sydney, Ultimo, Sydney, New South Wales 2007, Australia
    Mol Cell Proteomics 8:1891-907. 2009
  5. ncbi Fasciola hepatica and lymnaeid snails occurring at very high altitude in South America
    S Mas-Coma
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Burjassot Valencia, Spain
    Parasitology 123:S115-27. 2001
  6. ncbi Characterisation of Lymnaea cubensis, L. viatrix and L. neotropica n. sp., the main vectors of Fasciola hepatica in Latin America, by analysis of their ribosomal and mitochondrial DNA
    M D Bargues
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Avenida Vicente Andrés Estellés s n, 46100 Burjassot, Valencia, Spain
    Ann Trop Med Parasitol 101:621-41. 2007
  7. pmc Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages
    Sheila Donnelly
    Level 6, Bldg 4, University of Technology Sydney, Cnr Thomas and Harris St, Ultimo, Sydney, NSW 2007, Australia
    FASEB J 22:4022-32. 2008
  8. ncbi Epidemiology of fascioliasis in human endemic areas
    S Mas-Coma
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Av Vincent Andrés Estellés s n, 46100 Burjassot, Valencia, Spain
    J Helminthol 79:207-16. 2005
  9. ncbi Hysteresis in thioredoxin-glutathione reductase (TGR) from the adult stage of the liver fluke Fasciola hepatica
    Alberto Guevara-Flores
    Departamento de Bioquimica, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Apartado Postal 70 159, 04510, DF Mexico
    Parasitol Int 60:156-60. 2011
  10. pmc Clinical presentation and management of Fasciola hepatica infection: single-center experience
    Muhsin Kaya
    Department of Gastroenterology, Dicle University School of Medicine, Diyarbakir 21280, Turkey
    World J Gastroenterol 17:4899-904. 2011

Detail Information

Publications292 found, 100 shown here

  1. ncbi An ultrasensitive capture ELISA for detection of Fasciola hepatica coproantigens in sheep and cattle using a new monoclonal antibody (MM3)
    Mercedes Mezo
    Centro de Investigaciones Agrarias, Mabegondo, PO Box 10, 15080 A Coruña, Spain
    J Parasitol 90:845-52. 2004
    ..immunosorbent assay (ELISA) using a new monoclonal antibody (mAb MM3) is reported for the detection of Fasciola hepatica excretory-secretory antigens (ESAs) in feces of infected hosts...
  2. pmc Liver fluke induces cholangiocarcinoma
    Banchob Sripa
    Department of Pathology, Khon Kaen University, Khon Kaen, Thailand
    PLoS Med 4:e201. 2007
  3. ncbi Elucidating the transcriptome of Fasciola hepatica - a key to fundamental and biotechnological discoveries for a neglected parasite
    Neil D Young
    Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia
    Biotechnol Adv 28:222-31. 2010
    ..Key representatives, such as Fasciola hepatica and F...
  4. pmc An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: proteins associated with invasion and infection of the mammalian host
    Mark W Robinson
    Institute for the Biotechnology of Infectious Diseases, University of Technology Sydney, Ultimo, Sydney, New South Wales 2007, Australia
    Mol Cell Proteomics 8:1891-907. 2009
    To infect their mammalian hosts, Fasciola hepatica larvae must penetrate and traverse the intestinal wall of the duodenum, move through the peritoneum, and penetrate the liver...
  5. ncbi Fasciola hepatica and lymnaeid snails occurring at very high altitude in South America
    S Mas-Coma
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Burjassot Valencia, Spain
    Parasitology 123:S115-27. 2001
    Fascioliasis due to the digenean species Fasciola hepatica has recently proved to be an important public health problem, with human cases reported in countries of the five continents, including severe symptoms and pathology, with ..
  6. ncbi Characterisation of Lymnaea cubensis, L. viatrix and L. neotropica n. sp., the main vectors of Fasciola hepatica in Latin America, by analysis of their ribosomal and mitochondrial DNA
    M D Bargues
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Avenida Vicente Andrés Estellés s n, 46100 Burjassot, Valencia, Spain
    Ann Trop Med Parasitol 101:621-41. 2007
    ..viatrix var. B elongata and Galba truncatula, appear to be frequently involved in the transmission of Fasciola hepatica in Central and South America, although specific classification within this morphologically and anatomically ..
  7. pmc Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages
    Sheila Donnelly
    Level 6, Bldg 4, University of Technology Sydney, Cnr Thomas and Harris St, Ultimo, Sydney, NSW 2007, Australia
    FASEB J 22:4022-32. 2008
    ..Using murine models for the helminth infections caused by Fasciola hepatica (Fh) and Schistosoma mansoni (Sm), we show that a secreted antioxidant, peroxiredoxin (Prx), induces ..
  8. ncbi Epidemiology of fascioliasis in human endemic areas
    S Mas-Coma
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Av Vincent Andrés Estellés s n, 46100 Burjassot, Valencia, Spain
    J Helminthol 79:207-16. 2005
    ..b>Fasciola hepatica has succeeded in expanding from its European original geographical area to colonize five continents, despite ..
  9. ncbi Hysteresis in thioredoxin-glutathione reductase (TGR) from the adult stage of the liver fluke Fasciola hepatica
    Alberto Guevara-Flores
    Departamento de Bioquimica, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Apartado Postal 70 159, 04510, DF Mexico
    Parasitol Int 60:156-60. 2011
    Thioredoxin-glutathione reductase (TGR) was purified from the adult stage of the liver fluke Fasciola hepatica. At 38° C and pH 7.8, specific activity values were 10.2U mg(-1) and 64...
  10. pmc Clinical presentation and management of Fasciola hepatica infection: single-center experience
    Muhsin Kaya
    Department of Gastroenterology, Dicle University School of Medicine, Diyarbakir 21280, Turkey
    World J Gastroenterol 17:4899-904. 2011
    ..To identify the characteristic clinical, laboratory and radiological findings and response to treatment in patients with fascioliasis...
  11. ncbi A PCR-RFLP assay for the distinction between Fasciola hepatica and Fasciola gigantica
    A Marcilla
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot Valencia, Spain
    Mol Cell Probes 16:327-33. 2002
    ..The causative agents, Fasciola hepatica and Fasciola gigantica, present geographical distributions, which overlap in many regions of Africa and Asia,..
  12. ncbi Triploid form of Fasciola in Japan: genetic relationships between Fasciola hepatica and Fasciola gigantica determined by ITS-2 sequence of nuclear rDNA
    T Itagaki
    Department of Parasitology, Faculty of Agriculture, Iwate University, Morioka, Japan
    Int J Parasitol 28:777-81. 1998
    The ITS-2 sequences from seven worms of the Japanese triploid form of Fasciola, two of Fasciola hepatica from Uruguay and four of Fasciola gigantica from Zambia and Indonesia were determined...
  13. ncbi Helminth pathogen cathepsin proteases: it's a family affair
    Mark W Robinson
    Institute for the Biotechnology of Infectious Diseases, University of Technology Sydney, Ultimo, Sydney, NSW, Australia
    Trends Biochem Sci 33:601-8. 2008
    ..The liver fluke Fasciola hepatica, an emerging human pathogen, expresses the largest cathepsin L cysteine protease family yet described...
  14. ncbi Fasciola hepatica: identification of molecular markers for resistant and susceptible Pseudosuccinea columella snail hosts
    Alfredo Gutierrez
    Laboratorio de Malacologia, Instituto Pedro Kouri, IPK Apartado 601, Marianao 13, Ciudad Habana, Cuba
    Exp Parasitol 105:211-8. 2003
    ..to search for genetic differences between Pseudosuccinea columella snails susceptible and resistant to Fasciola hepatica infection...
  15. ncbi Fasciola antigens as vaccines against fascioliasis and schistosomiasis
    G V Hillyer
    Department of Pathology and Laboratory Medicine, University of Puerto Rico School of Medicine, San Juan PR 00936 5067, Puerto Rico
    J Helminthol 79:241-7. 2005
    ..In the case of Fasciola hepatica FABP, cross-reaction and cross-protection against Schistosoma mansoni is an important feature...
  16. ncbi High fascioliasis infection in children linked to a man-made irrigation zone in Peru
    J Guillermo Esteban
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Burjassot, Valencia
    Trop Med Int Health 7:339-48. 2002
    ..The area proved to be hyperendemic for human fascioliasis with a 24.3% overall mean prevalence of Fasciola hepatica, local prevalences ranging between 18.8 and 31...
  17. ncbi Relationships between host species and morphometric patterns in Fasciola hepatica adults and eggs from the northern Bolivian Altiplano hyperendemic region
    M A Valero
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    Vet Parasitol 102:85-100. 2001
    The highest prevalences and intensities of human fasciolosis by Fasciola hepatica are found in the northern Bolivian Altiplano, where sheep and cattle are the main reservoir host species and pigs and donkeys the secondary ones...
  18. ncbi MM3-ELISA detection of Fasciola hepatica coproantigens in preserved human stool samples
    Florencio M Ubeira
    Laboratorio de Parasitologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
    Am J Trop Med Hyg 81:156-62. 2009
    ..We concluded that the MM3-COPRO ELISA combined with the use of CoproGuard may be a very useful tool for the diagnosis of human fascioliasis...
  19. pmc Dynamics of antigenemia and coproantigens during a human Fasciola hepatica outbreak
    A M Espino
    Departamento de Parasitologia, Instituto de Medicina Tropical Pedro Kouri IPK, Ciudad de La Habana, Cuba
    J Clin Microbiol 36:2723-6. 1998
    In the present study the dynamics of antigenemia and coproantigens were studied in patients with Fasciola hepatica infection during an outbreak occurring in La Palma, Pinar del Río, in the West Province of Cuba...
  20. ncbi High endemicity of human fascioliasis between Lake Titicaca and La Paz valley, Bolivia
    J G Esteban
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Spain
    Trans R Soc Trop Med Hyg 93:151-6. 1999
    Over a 6-year period, an epidemiological study of human infection by Fasciola hepatica in the Northern Bolivian Altiplano was carried out...
  21. ncbi Fluke egg characteristics for the diagnosis of human and animal fascioliasis by Fasciola hepatica and F. gigantica
    M Adela Valero
    Departamento de Parasitologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    Acta Trop 111:150-9. 2009
    ..Fasciolid egg size in human stool samples ought to be corrected in books and monographs related to medical parasitology and/or tropical medicine as well as in guides for clinicians and parasitic disease diagnosis analysts...
  22. ncbi Comparative proteomics of excretory-secretory proteins released by the liver fluke Fasciola hepatica in sheep host bile and during in vitro culture ex host
    Russell M Morphew
    Institute of Biological Sciences, University of Wales, Aberystwyth, Wales SY23 3DA, United Kingdom
    Mol Cell Proteomics 6:963-72. 2007
    Livestock infection by the parasitic fluke Fasciola hepatica causes major economic losses worldwide. The excretory-secretory (ES) products produced by F...
  23. ncbi Understanding triclabendazole resistance
    G P Brennan
    Queen s University of Belfast, Belfast, N Ireland
    Exp Mol Pathol 82:104-9. 2007
    ..The review will also consider ways to deal with resistance, covering drug-oriented options such as: the use of alternative drugs, drug combinations and the search for new compounds...
  24. ncbi Proteomic analysis of glutathione transferases from the liver fluke parasite, Fasciola hepatica
    Gustavo Chemale
    School of Biological Sciences, University of Liverpool, Liverpool, UK
    Proteomics 6:6263-73. 2006
    The parasite Fasciola hepatica causes major global disease of livestock, with increasing reports of human infection. Vaccine candidates with varying protection rates have been identified by pre-genomic approaches...
  25. ncbi Involvement of a mitochondrial pathway and key role of hydrogen peroxide during eosinophil apoptosis induced by excretory-secretory products from Fasciola hepatica
    Marianela C Serradell
    Centro de Investigaciones en Bioquimica Clinica e Inmunologia, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Departamento Bioquimica Clinica, Facultad Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    Mol Biochem Parasitol 163:95-106. 2009
    ..Previously, we demonstrated that excretory-secretory products (ESP) from Fasciola hepatica induce eosinophil apoptosis by a caspase-dependent mechanism...
  26. ncbi A fatty acid binding protein from Fasciola hepatica induced protection in C57/BL mice from challenge infection with Schistosoma bovis
    J L Abán
    Laboratorio de Parasitologia, Facultad de Farmacia, Universidad de Salamanca, Spain
    Vet Parasitol 83:107-21. 1999
    Three strains of mice (NMRI, C57/BL, BALB/c) were each immunized with a 12 kDa purified, native Fasciola hepatica fatty acid binding protein (Fh12) and challenged percutaneously with Schistosoma bovis cercariae...
  27. ncbi Evaluation of an ELISA to assess the intensity of Fasciola hepatica infection in cattle
    M R Salimi-Bejestani
    School of Veterinary Medicine, University of Semnan, Semnan, Iran
    Vet Rec 162:109-11. 2008
    ..of 98 per cent and specificity of 96 per cent was evaluated as a means of assessing the intensity of Fasciola hepatica infection in cattle...
  28. ncbi The immune response of rats to vaccination with the cDNA or protein forms of the cysteine proteinase of Fasciola hepatica
    H Wedrychowicz
    W Stefanski Institute of Parasitology PAS, Twarda 51 55, 00 818 Warsaw, Poland
    Vet Immunol Immunopathol 94:83-93. 2003
    ..hepatica infection...
  29. ncbi The detection of snail host habitats in liver fluke infected farms by use of plant indicators
    Daniel Rondelaud
    UPRES EA 3174, Faculty of Pharmacy, 87025 Limoges, France
    Vet Parasitol 181:166-73. 2011
    ..The positive sites may be detected using a two-step method including first categorization of hydrographical zones and then, within a zone, use of one or several indicator plants (frequently J. acutiflorus)...
  30. pmc Burden of Fasciola hepatica Infection among children from Paucartambo in Cusco, Peru
    Martha Lopez
    Laboratorio Clinico Ser Salud, Cusco, Peru
    Am J Trop Med Hyg 86:481-5. 2012
    ..Parasite eggs and/or larvae were identified in 46.2% of subjects, including Fasciola hepatica in 10.3% of subjects. Fascioliasis was independently associated with anemia (adjusted odds ratio = 3.01 [1...
  31. ncbi A recombinant thioredoxin-glutathione reductase from Fasciola hepatica induces a protective response in rabbits
    Gabriela Maggioli
    Departamento de Bioquimica y Biologia Molecular, Instituto Universitario de Biotecnologia de Asturias, Universidad de Oviedo, 33006 Oviedo, Spain
    Exp Parasitol 129:323-30. 2011
    ..the cloning, heterologous expression, and characterization of a thioredoxin glutathione reductase (TGR) from Fasciola hepatica. The deduced polypeptide sequence of the cloned open reading frame (ORF) confirmed the experimental N-..
  32. pmc Fasciola hepatica is associated with the failure to detect bovine tuberculosis in dairy cattle
    Jen Claridge
    Institute of Infection and Global Health and School of Veterinary Science, University of Liverpool, Liverpool L69 7ZJ, UK
    Nat Commun 3:853. 2012
    ..hepatica. This finding may in part explain the continuing spread of BTB and the failure of the current eradication programme in the United Kingdom...
  33. pmc Towards delineating functions within the fasciola secreted cathepsin l protease family by integrating in vivo based sub-proteomics and phylogenetics
    Russell M Morphew
    Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth, United Kingdom
    PLoS Negl Trop Dis 5:e937. 2011
    b>fasciola hepatica, along with Fasciola gigantica, is the causative agent of fasciolosis, a foodborne zoonotic disease affecting grazing animals and humans worldwide...
  34. ncbi Fasciola hepatica phenotypic characterization in Andean human endemic areas: valley versus altiplanic patterns analysed in liver flukes from sheep from Cajamarca and Mantaro, Peru
    M Adela Valero
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    Infect Genet Evol 12:403-10. 2012
    Fascioliasis is a zoonotic parasitic disease caused by Fasciola hepatica and Fasciola gigantica. Of both species, F...
  35. ncbi Exploring the Fasciola hepatica tegument proteome
    R Alan Wilson
    Centre for Immunology and Infection, Department of Biology, University of York, Heslington, York YO10 5DD, United Kingdom
    Int J Parasitol 41:1347-59. 2011
    The surface tegument of the liver fluke Fasciola hepatica is a syncytial cytoplasmic layer bounded externally by a plasma membrane and covered by a glycocalyx, which constitutes the interface between the parasite and its ruminant host...
  36. ncbi Reducing the future threat from (liver) fluke: realistic prospect or quixotic fantasy?
    Ian Fairweather
    Parasite Therapeutics Research Group, School of Biological Sciences, Medical Biology Centre, The Queen s University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom
    Vet Parasitol 180:133-43. 2011
    ..problems (of increasing incidence and drug resistance) is the overall theme of the session on "Trematodes: Fasciola hepatica epidemiology and control" and of this review to introduce the session...
  37. ncbi Infection with Fasciola hepatica
    D Y Aksoy
    Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey
    Clin Microbiol Infect 11:859-61. 2005
    Fascioliasis, caused by the liver fluke Fasciola hepatica, is an infection that occurs worldwide, although humans are accidental hosts. F. hepatica infection comprises two stages, hepatic and biliary, with different signs and symptoms...
  38. ncbi Hepatic fibrosis and Fasciola hepatica infection in cattle
    Luis A Marcos
    Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
    J Helminthol 81:381-6. 2007
    This study focuses on the development of fibrosis of the liver of cattle with Fasciola hepatica infection, correlating with the intensity of infection. Animals with an established diagnosis of chronic F...
  39. ncbi Association between anti-F. hepatica antibody levels in milk and production losses in dairy cows
    Mercedes Mezo
    Laboratorio de Parasitologia, Centro de Investigaciones Agrarias de Mabegondo, Instituto Galego de Calidade Alimentaria Xunta de Galicia, Carretera AC 542 de Betanzos a Mesón do Vento, Km 7, CP 15318, Abegondo A Coruña, Spain
    Vet Parasitol 180:237-42. 2011
    This study was conducted to determine: (1) the associations between anti-Fasciola hepatica antibody levels in milk and some productive and reproductive parameters in dairy cattle, and (2) the threshold antibody level associated with loss ..
  40. ncbi Phenotypic analysis of adults of Fasciola hepatica, Fasciola gigantica and intermediate forms from the endemic region of Gilan, Iran
    K Ashrafi
    Department of Medical Microbiology and Parasitology, School of Medicine, Gilan University of Medical Sciences, Gilan University Complex, Rasht, Iran
    Parasitol Int 55:249-60. 2006
    Fascioliasis is an important human and animal disease caused by Fasciola hepatica and Fasciola gigantica...
  41. ncbi Diagnosis of human fasciolosis in the Gilan province of Northern Iran: application of cathepsin L-ELISA
    Mohammad B Rokni
    Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Diagn Microbiol Infect Dis 44:175-9. 2002
    ....
  42. ncbi Identification of a novel Fasciola hepatica cathepsin L protease containing protective epitopes within the propeptide
    Michiel M Harmsen
    Animal Sciences Group of Wageningen University and Research Centre, P O Box 65, 8200 AB Lelystad, The Netherlands
    Int J Parasitol 34:675-82. 2004
    ..identified an immunogenic 32 kDa protein specifically present in newly excysted juveniles (NEJs) of Fasciola hepatica. Here we show by N-terminal protein sequencing that this protein represents a CL-like protease still ..
  43. ncbi The use of MM3 monoclonal antibodies for the early immunodiagnosis of ovine fascioliasis
    Mercedes Mezo
    Centro de Investigaciones Agrarias, Mabegondo, P O Box 10, 15080, A Coruna, Spain
    J Parasitol 93:65-72. 2007
    ..previously reported indirect ELISA method, based on the use of a FPLC-purified fraction (fraction IV) of the Fasciola hepatica excretion/secretion antigens (ESAs), this new test was able to detect animals infected with very small ..
  44. ncbi Fasciola hepatica in the human eye
    Abdolhossein Dalimi
    Department of Parasitology, Medical Sciences Faculty, Tarbiat Modarres University, Tehran, Iran
    Trans R Soc Trop Med Hyg 99:798-800. 2005
    ..According to morphological characterisation of the parasite, it was identified as Fasciola hepatica. The route of entry of the parasite was not identified...
  45. pmc In vivo and in vitro sensitivity of Fasciola hepatica to triclabendazole combined with artesunate, artemether, or OZ78
    Urs Duthaler
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Antimicrob Agents Chemother 54:4596-604. 2010
    Triclabendazole resistance is continually documented from livestock, and hence new treatment strategies for Fasciola hepatica infections are needed...
  46. ncbi Identification and differentiation of Fasciola hepatica and Fasciola gigantica using a simple PCR-restriction enzyme method
    Mohammad Bagher Rokni
    Department of Medical Parasitology and Mycology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran
    Exp Parasitol 124:209-13. 2010
    Accurate morphological differentiation between the liver fluke species Fasciola hepatica and Fasciola gigantica is difficult...
  47. ncbi Fasciola hepatica: tegumental alterations in adult flukes following in vitro and in vivo administration of artesunate and artemether
    Jennifer Keiser
    Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Exp Parasitol 118:228-37. 2008
    The tegumental changes in adult Fasciola hepatica induced by artemether and artesunate were assessed utilizing scanning electron microscopy (SEM). F...
  48. ncbi A study of the liver of goats immunized with a synthetic peptide of the Sm14 antigen and challenged with Fasciola hepatica
    R Zafra
    Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria de Cordoba, Edificio de Sanidad Animal, Campus de Rabanales, Ctra Madrid Cadiz, Km 396, 14014 Cordoba
    J Comp Pathol 139:169-76. 2008
    ..of the Sm14 antigen of Schistosoma mansoni was used to immunize goats against experimental challenge with Fasciola hepatica. The goats used consisted of: group 1 (unimmunized and uninfected [controls]); group 2 (unimmunized and ..
  49. ncbi Proteomic analysis of embryonic Fasciola hepatica: characterization and antigenic potential of a developmentally regulated heat shock protein
    Joseph V Moxon
    Institute of Biological, Environmental and Rural Sciences IBERS, Edward Llwyd Building, Aberystwyth University, UK
    Vet Parasitol 169:62-75. 2010
    b>Fasciola hepatica is responsible for human disease and economic livestock loss on a global scale. We report the first post-genomic investigation of cellular proteins expressed by embryonic F...
  50. ncbi A distinctive repertoire of cathepsins is expressed by juvenile invasive Fasciola hepatica
    Martin Cancela
    Departamento de Genetica, Facultad de Medicina, Universidad de la Republica, UDELAR, Montevideo, Uruguay
    Biochimie 90:1461-75. 2008
    ..In the trematode Fasciola hepatica, the initial step to successful infection of the mammalian host is the excystment of metacercariae and the ..
  51. ncbi Phenotypic analysis of adults and eggs of Fasciola hepatica by computer image analysis system
    M A Valero
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    J Helminthol 79:217-25. 2005
    Knowledge of the morphological phenotypes of the liver fluke Fasciola hepatica (Trematoda: Digenea) is analysed...
  52. ncbi Seroprevalence and spatial distribution of Fasciola hepatica-infected dairy herds in England and Wales
    C M McCann
    Veterinary Parasitology, Infection Biology Group, Department of Comparative Molecular Medicine, School of Veterinary Science, University of Liverpool, Liverpool L69 7ZJ
    Vet Rec 166:612-7. 2010
    The seroprevalence of Fasciola hepatica infection in a population of commercial dairy herds in England and Wales was estimated using an ELISA that detected antibodies to F hepatica in bulk tank milk...
  53. ncbi Phenotypic comparison of allopatric populations of Fasciola hepatica and Fasciola gigantica from European and African bovines using a computer image analysis system (CIAS)
    M V Periago
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Av Vicente Andrés Estellés s n, 46100, Burjassot, Valencia, Spain
    Parasitol Res 99:368-78. 2006
    The quantification of the different sizes and shapes of Fasciola hepatica and Fasciola gigantica from bovines has been achieved for the first time in natural allopatric populations...
  54. ncbi Comparative infectivity of Fasciola hepatica metacercariae from isolates of the main and secondary reservoir animal host species in the Bolivian Altiplano high human endemic region
    M A Valero
    Department of Parasitology, Faculty of Pharmacy, University of Valencia, Burjassot, Spain
    Folia Parasitol (Praha) 47:17-22. 2000
    Fascioliasis due to Fasciola hepatica (Linnaeus, 1758) is an endemic disease on the Northern Bolivian Altiplano, where human prevalences and intensities are the highest known, sheep and cattle are the main reservoir hosts, and pigs and ..
  55. ncbi The occurrence and significance of triploidy in the liver fluke, Fasciola hepatica
    H L Fletcher
    Parasite Proteomics and Therapeutics Research Group, The Queen s University of Belfast, School of Biology and Biochemistry, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Parasitology 128:69-72. 2004
    Karyotyping of Fasciola hepatica samples from Britain and Ireland has identified a triploid isolate which is effectively aspermic, rendering it necessarily asexually reproducing...
  56. ncbi Pseudosuccinea columella (Say 1817) (Gastropoda, Lymnaeidae), snail host of Fasciola hepatica: first record for France in the wild
    Jean Pierre Pointier
    Biologie et Ecologie Tropicale et Méditerranéenne, UMR 5244 CNRS EPHE UPVD, Université Via Domitia, 52 Avenue Paul Alduy, 66860, Perpignan Cedex, France
    Parasitol Res 101:1389-92. 2007
    ..columella isolate obtained in the laboratory was used for parasitological tests with a French Fasciola hepatica sample. Experimental infections showed that 100% of snails (n=26) developed infection when exposed to F...
  57. ncbi Insights into the relationships of Palearctic and Nearctic lymnaeids (Mollusca: Gastropoda) by rDNA ITS-2 sequencing and phylogeny of stagnicoline intermediate host species of Fasciola hepatica
    M D Bargues
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    Parasite 10:243-55. 2003
    Fascioliasis by Fasciola hepatica is the vector-borne disease presenting the widest latitudinal, longitudinal and altitudinal distribution known. F...
  58. pmc Survey of transcripts expressed by the invasive juvenile stage of the liver fluke Fasciola hepatica
    Martin Cancela
    Departamento de Biologia Molecular e Biotecnologia, Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil
    BMC Genomics 11:227. 2010
    The common liver fluke Fasciola hepatica is the agent of a zoonosis with significant economic consequences in livestock production worldwide, and increasing relevance to human health in developing countries...
  59. ncbi Immunodiagnosis of fasciolosis using recombinant procathepsin L cystein proteinase
    S Carnevale
    Departamento de Parasitologia, ANLIS Dr Carlos G Malbran, Av Velez Sarsfield 563, 1281, Buenos Aires, Argentina
    Diagn Microbiol Infect Dis 41:43-9. 2001
    Cathepsin L1, a cysteine protease secreted by the gastrodermis of juvenile and adult Fasciola hepatica, was expressed in Escherichia coli as a fusion protein containing the proregion, supplied with six histidyl residues at the N-terminal ..
  60. ncbi Detection of Fasciola hepatica infection in a community located in the Ecuadorian Andes
    G Trueba
    Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Ecuador
    Am J Trop Med Hyg 62:518. 2000
    ..Andean communities using an enzyme-linked immunosorbent assay (ELISA) test to measure antibodies against Fasciola hepatica excretion-secretion antigens...
  61. ncbi An interactive map to assess the potential spread of Lymnaea truncatula and the free-living stages of Fasciola hepatica in Switzerland
    Christina Rapsch
    Vetsuisse Faculty Zurich, Department of Farm Animals, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    Vet Parasitol 154:242-9. 2008
    The intermediate host of Fasciola hepatica is Lymnaea truncatula in Switzerland. The snail and the free-living stages of the parasite require a moderate climate and moisture for survival, reproduction, and transmission...
  62. ncbi Fasciola hepatica and Fasciola gigantica: cloning and characterisation of 70 kDa heat-shock proteins reveals variation in HSP70 gene expression between parasite species recovered from sheep
    Rebecca E Smith
    Animal Biotechnology Research Laboratories, Department of Physiology, Monash University, Building 13D, Clayton 3800, Australia
    Exp Parasitol 118:536-42. 2008
    b>Fasciola hepatica and Fasciola gigantica are trematode parasites responsible for fasciolosis, a disease of ruminant animals which is also increasingly recognised as a disease in humans...
  63. ncbi MM3-ELISA evaluation of coproantigen release and serum antibody production in sheep experimentally infected with Fasciola hepatica and F. gigantica
    M Adela Valero
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    Vet Parasitol 159:77-81. 2009
    During an experimental infection of sheep with Fasciola hepatica or F...
  64. ncbi Identification of enolase as a plasminogen-binding protein in excretory-secretory products of Fasciola hepatica
    Dolores Bernal
    Departament de Bioquímica y Biologia Molecular, Facultat de Ciencies, Universitat de Valencia, C Dr Moliner, 50, 46100 Burjassot, Valencia, Spain
    FEBS Lett 563:203-6. 2004
    We have followed a combined proteomic approach to identify proteins of Fasciola hepatica that could be involved in host-parasite interactions...
  65. pmc Experimental Fasciola hepatica infection alters responses to tests used for diagnosis of bovine tuberculosis
    Robin J Flynn
    Veterinary Sciences Centre, School of Agriculture, Food Science and Veterinary Medicine, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
    Infect Immun 75:1373-81. 2007
    b>Fasciola hepatica is a prevalent helminth parasite of livestock. Infection results in polarization of the host's immune response and generation of type 2 helper (Th2) immune responses, which are known to be inhibitory to Th1 responses...
  66. ncbi Excretory-secretory products from Fasciola hepatica induce eosinophil apoptosis by a caspase-dependent mechanism
    Marianela C Serradell
    Parasitologia, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, CIBICI CONICET, Medina Allende y Haya de la Torre, Ciudad Universitaria, 5000 Cordoba, Argentina
    Vet Immunol Immunopathol 117:197-208. 2007
    ..We investigated the ability of ESP from Fasciola hepatica to induce Eo apoptosis...
  67. ncbi The effect of cyclic temperatures on the growth of Fasciola hepatica and Lymnaea viatrix
    J R Claxton
    University of Liverpool, Department of Veterinary Clinical Science and Animal Husbandry, Leahurst, Neston, UK
    Vet J 157:166-71. 1999
    ..variable temperatures on the growth of Lymnaea viatrix snails, on the development of a Peruvian isolate of Fasciola hepatica eggs and on the development of F. hepatica in the snails...
  68. pmc Predicting impacts of climate change on Fasciola hepatica risk
    Naomi J Fox
    Animal Health, Scottish Agricultural College, Edinburgh, United Kingdom
    PLoS ONE 6:e16126. 2011
    b>Fasciola hepatica (liver fluke) is a physically and economically devastating parasitic trematode whose rise in recent years has been attributed to climate change...
  69. pmc Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses
    David J Dowling
    Parasite Immune Modulation Group, School of Nursing, Faculty of Science and Health, Dublin City University, Glasnevin, Dublin 9, Ireland
    Infect Immun 78:793-801. 2010
    b>Fasciola hepatica is a helminth pathogen that drives Th2/Treg immune responses in its mammalian host. The parasite releases a large number of molecules that are critical to inducing this type of immune response...
  70. ncbi Excretory-secretory products (ESP) from Fasciola hepatica induce tolerogenic properties in myeloid dendritic cells
    Cristian Falcón
    Departamento de Bioquimica Clinica, CIBICI CONICET, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Haya de la Torre y Medina Allende, 5000 Cordoba, Argentina
    Vet Immunol Immunopathol 137:36-46. 2010
    b>Fasciola hepatica is a helminth trematode that migrates through the host tissues until reaching bile ducts where it becomes an adult...
  71. pmc Peritoneal lavage cells of Indonesian thin-tail sheep mediate antibody-dependent superoxide radical cytotoxicity in vitro against newly excysted juvenile Fasciola gigantica but not juvenile Fasciola hepatica
    David Piedrafita
    Department of Physiology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    Infect Immun 75:1954-63. 2007
    ..hepatica to superoxide-mediated killing. We suggest that ovine macrophages and eosinophils, acting in concert with a specific antibody, may be important effector cells involved in the resistance of ITT sheep to F. gigantica...
  72. ncbi The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference reduces gut penetration
    Louise McGonigle
    Biomolecular Processes Parasitology, School of Biological Sciences, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Int J Parasitol 38:149-55. 2008
    ..Here, we show the successful silencing of the cysteine proteases cathepsin B and L in the infective stage of Fasciola hepatica newly excysted juveniles (NEJs)...
  73. pmc The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine protease
    Jonathan Lowther
    Institute for the Biotechnology of Infectious Diseases IBID, University of Technology Sydney UTS, Ultimo, Sydney, New South Wales, Australia
    PLoS Negl Trop Dis 3:e369. 2009
    The helminth parasite Fasciola hepatica secretes cathepsin L cysteine proteases to invade its host, migrate through tissues and digest haemoglobin, its main source of amino acids...
  74. ncbi Evaluation of Fas2-ELISA for the serological detection of Fasciola hepatica infection in humans
    Jose R Espinoza
    Unit of Molecular Biotechnology, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru
    Am J Trop Med Hyg 76:977-82. 2007
    The performance of Fas2-ELISA for the diagnosis of Fasciola hepatica infection in children living in areas of high endemicity for fascioliasis in the Peruvian Andes is analyzed...
  75. ncbi Alternative activation of ruminant macrophages by Fasciola hepatica
    R J Flynn
    Veterinary Sciences Centre, School of Agriculture, Food Science and Veterinary Medicine, College of Life Science, University College Dublin, Belfield, Dublin 4, Ireland
    Vet Immunol Immunopathol 120:31-40. 2007
    The helminth parasite, Fasciola hepatica, has a worldwide distribution and infects a wide variety of mammalian hosts, including ruminants and man...
  76. ncbi Biochemical characterisation of the recombinant peroxiredoxin (FhePrx) of the liver fluke, Fasciola hepatica
    Mary Sekiya
    School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
    FEBS Lett 580:5016-22. 2006
    The parasitic helminth Fasciola hepatica secretes a 2-Cys peroxiredoxin (Prx) that may play important functions in host-parasite interaction...
  77. ncbi Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propetide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells
    Peter R Collins
    School of Biotechnology, Dublin City University, Dublin 9, Republic of Ireland
    J Biol Chem 279:17038-46. 2004
    ..activation of the major cathepsin L1 cysteine protease involved in the virulence of the helminth pathogen Fasciola hepatica was investigated...
  78. ncbi More efficient allopatric combinations of Fasciola hepatica and Lymnaea truncatula due to modification of redial development?
    M D Goumghar
    Faculte des Sciences, Université Sidi Mohamed Ben Abdallah, Fes Atlas, Morocco
    Parasitol Res 87:1016-9. 2001
    ..and Saint Ours) with an allopatric (Fès, Morocco) or a semi-sympatric (Limoges, France) isolate of Fasciola hepatica miracidia were performed to determine the effect of allopatric miracidia on redial and cercarial production...
  79. ncbi Associations between anti-Fasciola hepatica antibody levels in bulk-tank milk samples and production parameters in dairy herds
    Johannes Charlier
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Prev Vet Med 78:57-66. 2007
    ..milk sample was collected in March 2004 from 1105 dairy herds in Flanders and the antibody levels against Fasciola hepatica (ODRf) and Ostertagia ostertagi (ODRo) were determined...
  80. ncbi Hybridization experiments indicate incomplete reproductive isolating mechanism between Fasciola hepatica and Fasciola gigantica
    T Itagaki
    Laboratory of Veterinary Parasitology, Faculty of Agriculture, Iwate University, Ueda 3 18 8, Morioka 020 8550, Japan
    Parasitology 138:1278-84. 2011
    Experiments on hybridization between Fasciola hepatica and Fasciola gigantica were carried out to clarify whether a reproductive isolating mechanism appears between the two Fasciola species...
  81. ncbi Effect of parasite burden on the detection of Fasciola hepatica antigens in sera and feces of experimentally infected sheep
    C Almazan
    Facultad de Medicina Veterinaria y Zootecnia, Departamento de Parasitologia, Universidad Autonoma de Tamaulipas, Km 5 carretera Victoria Mante, Cd Victoria, Tamaulipas CP 87000, Mexico
    Vet Parasitol 97:101-12. 2001
    The effect of Fasciola hepatica parasite burden on the detection of excretory/secretory (E/S) antigens in sera and feces of experimentally infected sheep was evaluated using a double antibody-based capture enzyme-linked immunosorbent ..
  82. ncbi Vaccination against fasciolosis by a multivalent vaccine of stage-specific antigens
    Ramamoorthi Jayaraj
    RMIT University, Bundoora, Victoria 3083, Australia
    Vet Parasitol 160:230-6. 2009
    ..Each was used singly or in combination to vaccinate rats that were subsequently challenged with Fasciola hepatica metercercariae...
  83. ncbi Fasciola hepatica infestation as a very rare cause of extrahepatic cholestasis
    Ahmet Dobrucali
    Division of Gastroenterology, Cerrahpasa Medical Faculty, Istanbul University, Turkey
    World J Gastroenterol 10:3076-7. 2004
    b>Fasciola hepatica, an endemic parasite in Turkey, is still a very rare cause of cholestasis worldwide. Through ingestion of contaminated water plants like watercress, humans can become the definitive host of this parasite...
  84. ncbi Mechanisms of liver fibrosis associated with experimental Fasciola hepatica infection: roles of Fas2 proteinase and hepatic stellate cell activation
    Luis A Marcos
    Washington University School of Medicine, Infectious Diseases Division, St Louis, Missouri, USA
    J Parasitol 97:82-7. 2011
    We have evaluated the possible mechanisms of liver fibrosis caused by Fasciola hepatica in an animal model and in culture using immortalized human stellate cells. Liver biopsies of F. hepatica-infected rats were performed at wk 8 and 16...
  85. ncbi High risk of bacterobilia in advanced experimental chronic fasciolosis
    M A Valero
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Av Vicente Andrés Estellés s n, 46100 Burjassot, Valencia, Spain
    Acta Trop 100:17-23. 2006
    Fasciolosis is recognized as an important human disease. Wistar rats experimentally infected with Fasciola hepatica were examined using data obtained in the advanced chronic state of the disease (200, 300 and 400 days post-infection, dpi)..
  86. ncbi Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1-P4 specificity reveals an unusual preference
    Luke J Norbury
    School of Applied Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    Biochimie 94:1119-27. 2012
    ..Finally, the P(1)-P(4) specificity of Fasciola cathepsin L5 was determined and, unexpectedly, aspartic acid was shown to be well accepted at P(2,) which is unique amongst Fasciola cathepsins examined to date...
  87. pmc The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function
    Clare M Hamilton
    School of Nursing, Dublin City University, Dublin, Ireland
    Infect Immun 77:2488-98. 2009
    ..The helminth Fasciola hepatica has been reported to suppress antigen-specific Th1 responses in concurrent bacterial infections, thus ..
  88. ncbi Serum antibody isotype responses of Fasciola-infected sheep and cattle to excretory and secretory products of Fasciola species
    I K Phiri
    Department of Clinical Studies, School of Veterinary Medicine, University of Zambia, P O Box 32379, Lusaka, Zambia
    Vet Parasitol 141:234-42. 2006
    This study investigated the immunoglobulin isotype responses of sheep and cattle chronically infected with Fasciola hepatica and Fasciola gigantica to adult F. hepatica excretory/secretory products (Fh-ES) or F...
  89. ncbi Triclabendazole resistance involving Fasciola hepatica in sheep and goats during an outbreak in Almirante Tamandare, Paraná, Brazil
    Diego R Oliveira
    Universidade Federal do Parana, Curitiba, PR, Brazil
    Rev Bras Parasitol Vet 17:149-53. 2008
    ..This study aims to determine the effectiveness of treatment against Fasciola hepatica on a sheep and goat farm during an outbreak of fasciolosis, in which a high proportion of deaths occurred...
  90. ncbi Correlation between egg-shedding and uterus development in Fasciola hepatica human and animal isolates: applied implications
    Maria Adela Valero
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Av Vicente Andrés Estellés s n, 46100 Burjassot, Valencia, Spain
    Vet Parasitol 183:79-86. 2011
    The emission of Fasciola hepatica eggs in faeces is usually subject to oscillations along time in animals as well as humans...
  91. ncbi Immunological detection of chemotherapeutic success in bovine fasciolosis using the specific antigen f2
    D Levieux
    INRA, Station de Recherches sur la Viande, Unité d Immunochimie, Theix, St Genes Champanelle, France
    Vet Parasitol 45:81-8. 1992
    An improved hemagglutination (HA) test using the purified specific f2 antigen of Fasciola hepatica has been evaluated with regard to its potential use for the prediction of chemotherapeutic success in natural bovine infections with F...
  92. ncbi Purification and characterisation of a second cathepsin L proteinase secreted by the parasitic trematode Fasciola hepatica
    A J Dowd
    School of Biological Sciences, Dublin City University, Ireland
    Eur J Biochem 223:91-8. 1994
    A 29.5-kDa cysteine proteinase was purified from medium in which mature Fasciola hepatica parasites were maintained...
  93. ncbi Antioxidant potential of rat liver in experimental infection with Fasciola hepatica
    L Kolodziejczyk
    Department of Biology and Medical Parasitology, Pomeranian Medical University, al Powstancow Wielkopolskich 72, 70 111 Szczecin, Poland
    Parasitol Res 96:367-72. 2005
    ..Wistar rats were infected per os with 30 metacercariae of Fasciola hepatica. Liver activities of antioxidant enzymes and concentrations of non-enzymatic antioxidants were determined at ..
  94. ncbi [Pathological changes of liver in infection of Fasciola hepatica]
    Agnieszka Gajewska
    Zakład Parazytologii i Inwazjologii, Wydział Medycyny Weterynaryjnej, SGGW, ul Ciszewskiego 8, 02 786 Warszawa
    Wiad Parazytol 51:115-23. 2005
    Pathological changes of liver in infection of Fasciola hepatica. Fasciolosis caused by Fasciola hepatica is a hepatic parasitic infection that affects numerous mammal species, mainly ruminants, in several countries of Europe, Asia and ..
  95. ncbi A recombinant antigen recognized by Fasciola hepatica-infected hosts
    Elisabete Silva
    Laboratorio de Parasitologia, Centro de Imunologia e Biologia Parasitária, Instituto Nacional de Saúde Dr Ricardo Jorge do Porto, Rua de São Luís N o 16, 4000 509 Porto, Portugal
    J Parasitol 90:746-51. 2004
    This work reports the detection of specific immunoglobulins (Ig) against rFh8, a recombinant Fasciola hepatica adult worm excretion-secretion antigen, in sera from experimentally (rabbit, Wistar rat, cattle, and sheep), or naturally (..
  96. ncbi The relationship between normocytic, hypochromic anaemia and iron concentration together with hepatic enzyme activities in cattle infected with Fasciola hepatica
    S Lotfollahzadeh
    Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
    J Helminthol 82:85-8. 2008
    ..in infected and uninfected cattle to determine the type of anaemia and degree of hepatic damage caused by Fasciola hepatica. Blood samples from 86 infected and 30 uninfected cattle were taken at slaughter...
  97. ncbi The roles of IL-10 and TGF-beta in controlling IL-4 and IFN-gamma production during experimental Fasciola hepatica infection
    Robin J Flynn
    Veterinary Sciences Centre, School of Agriculture Food Science and Veterinary Medicine, College of Life Sciences, University College Dublin, Ireland
    Int J Parasitol 38:1673-80. 2008
    Hosts infected with Fasciola hepatica experience immunosuppression during the acute and chronic phases of the disease. This immunosuppression may allow parasite survival in the face of an ongoing immune response...
  98. ncbi Fasciola hepatica products induce apoptosis of peritoneal macrophages
    Lorena Guasconi
    Centro de Investigaciones en Bioquímica Clínica e Inmunología CIBICI, CONICET, Departamento de Bioquimica Clinica, Universidad Nacional de Cordoba, Medina Allende y Haya de la Torre, Ciudad Universitaria, Cordoba, Argentina
    Vet Immunol Immunopathol 148:359-63. 2012
    Immunomodulatory properties have been described for Fasciola hepatica excretory-secretory products (FhESP), with their interaction with the innate immune cells being crucial during the early stages of infection...
  99. ncbi Fasciola hepatica and parasitic eosinophilic granuloma of the Liver
    Jorge Vercelli-Retta
    Am J Surg Pathol 26:1238. 2002
  100. ncbi Fasciola hepatica and Paramphistomum daubneyi: changes in prevalences of natural infections in cattle and in Lymnaea truncatula from central France over the past 12 years
    Christian Mage
    Institut de l Elevage, Ester Technopole, Limoges et Groupement de Défense Sanitaire de la Corrèze, Tulle, France
    Vet Res 33:439-47. 2002
    ....
  101. ncbi Identification of fatty acid molecules in a Fasciola hepatica immunoprophylactic fatty acid-binding protein
    A M Espino
    Laboratory of Parasite Immunology and Pathology, University of Puerto Rico School of Medicine, San Juan 00936, USA
    J Parasitol 87:426-8. 2001
    b>Fasciola hepatica adult flukes have a native protein complex denoted nFh12 and consisting of fatty acid binding proteins that comprise at least 8 isoforms...

Research Grants11

  1. Towards a vaccine against Fasciola hepatica using FhSAP2 as an antigen
    Ana M Espino; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The helminth parasite Fasciola hepatica causes liver fluke disease or fascioliasis, thereby affecting the health of humans, as well as sheep, cattle and goats, among others mammalians...
  2. Trematocidal Synthetic Perioxides
    JONATHAN VENNERSTROM; Fiscal Year: 2009
    ..activity and selectivity of target synthetic peroxides against two major human food-borne trematode species, Fasciola hepatica and Clonorchis sinensis...
  3. Effects of HAART drugs on endothelial dysfunction of pu*
    Changyi Chen; Fiscal Year: 2009
    ..abstract_text> ..
  4. Molecular Surgeon Symposium on Genetics and Genomics of Pancreatic Cancer
    Changyi Chen; Fiscal Year: 2008
    ..Furthermore, invited speakers are encouraged to submit manuscripts related to their presentations to "World Journal of Surgery" for consideration of publications. [unreadable] [unreadable] [unreadable]..
  5. Tissue engineering of small diameter vascular graft
    Changyi Chen; Fiscal Year: 2006
    ..Success of this proposal will directly indicate the clinical applications of tissue engineered small diameter vascular grafts. ..
  6. Molecular Surgeon Symposium on Vascular Injury, Repair
    Changyi Chen; Fiscal Year: 2005
    ..A pre-approved letter for acceptance of submission of this application from NIH/NHLBI is included. ..
  7. Effects of HIV Protease Inhibitors of Endothelial Barrie
    Changyi Chen; Fiscal Year: 2005
    ..Our findings may also suggest new therapeutic strategies, which may eventually prove effective for the prevention and treatment of these complications. ..
  8. HIV PROTEASE INHIBITORS EFFECT--NENDOTHELIAL DYSFUNCTION
    Changyi Chen; Fiscal Year: 2004
    ..Together, the integrated basic science, non-human primate and human investigations offer a multi disciplinary approach to the understanding and prevention of protease inhibitor-associated vascular complications. ..
  9. HIV/SIV ENVELOPE GLYCOPROTEIN EFFECTS ON ENDOTHELIA
    Changyi Chen; Fiscal Year: 2002
    ....
  10. ANGIOTENSIN II AND REGULATION OF MCP-1 GENE EXPRESSION
    Changyi Chen; Fiscal Year: 2002
    ....
  11. Am Soc of Tropical Medicine and Hygiene Annual Meeting
    George Hillyer; Fiscal Year: 2008
    ..A critical need is to obtain financial support for graduate and postdoctoral students, our future specialists in the different areas of tropical medicine, to attend and be part of the annual meeting of this Society. ..