nematospiroides dubius

Summary

Summary: A species of intestinal nematode parasites which occur most commonly in mice. Infection is by ingesting larvae. This particular species is used extensively in immunological research.

Top Publications

  1. pmc Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway
    John R Grainger
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    J Exp Med 207:2331-41. 2010
  2. pmc Expansion and activation of CD4(+)CD25(+) regulatory T cells in Heligmosomoides polygyrus infection
    Constance A M Finney
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 37:1874-86. 2007
  3. pmc Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation
    Mark S Wilson
    Centre for Immunity, Infection and Evolution, and Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 40:1682-96. 2010
  4. ncbi Immune modulation and modulators in Heligmosomoides polygyrus infection
    Rick M Maizels
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, UK
    Exp Parasitol 132:76-89. 2012
  5. ncbi Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection
    Kathy D McCoy
    Institute of Experimental Immunology, Department of Pathology, Universitatsspital, CH8091 Zurich, Switzerland
    Cell Host Microbe 4:362-73. 2008
  6. pmc B cells have distinct roles in host protection against different nematode parasites
    Qian Liu
    Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA
    J Immunol 184:5213-23. 2010
  7. pmc Functional analysis of effector and regulatory T cells in a parasitic nematode infection
    Sebastian Rausch
    Department of Molecular Parasitology, Humboldt University Berlin, Philippstr 13, 10115 Berlin, Germany
    Infect Immun 76:1908-19. 2008
  8. pmc Suppression of allergic airway inflammation by helminth-induced regulatory T cells
    Mark S Wilson
    Institute of Immunology and Infection Research, University of Edinburgh, UK
    J Exp Med 202:1199-212. 2005
  9. pmc Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection
    De Broski R Herbert
    Research Service, Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45220, USA
    J Exp Med 206:2947-57. 2009
  10. ncbi Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloCD103- dendritic cells
    Katherine A Smith
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    J Immunol 186:7098-109. 2011

Scientific Experts

Detail Information

Publications138 found, 100 shown here

  1. pmc Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway
    John R Grainger
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    J Exp Med 207:2331-41. 2010
    ..We have therefore identified a novel pathway through which helminth parasites may stimulate T reg cells, which is likely to be a key part of the parasite's immunological relationship with the host...
  2. pmc Expansion and activation of CD4(+)CD25(+) regulatory T cells in Heligmosomoides polygyrus infection
    Constance A M Finney
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 37:1874-86. 2007
    ....
  3. pmc Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation
    Mark S Wilson
    Centre for Immunity, Infection and Evolution, and Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 40:1682-96. 2010
    ..These data expand previous observations and highlight the broad regulatory environment that develops during helminth infections that can abate diverse inflammatory disorders in vivo...
  4. ncbi Immune modulation and modulators in Heligmosomoides polygyrus infection
    Rick M Maizels
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, UK
    Exp Parasitol 132:76-89. 2012
    ..Proteomic and transcriptomic definition of parasite proteins, combined with biochemical identification of immunogenic molecules in resistant mice, will provide new candidate immunomodulators and vaccine antigens for future research...
  5. ncbi Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection
    Kathy D McCoy
    Institute of Experimental Immunology, Department of Pathology, Universitatsspital, CH8091 Zurich, Switzerland
    Cell Host Microbe 4:362-73. 2008
    ....
  6. pmc B cells have distinct roles in host protection against different nematode parasites
    Qian Liu
    Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA
    J Immunol 184:5213-23. 2010
    ..This study suggests variability in the importance of B cells in mediating protection against intestinal nematode parasites, and it indicates an important role for Ab in resistance to tissue-dwelling parasites...
  7. pmc Functional analysis of effector and regulatory T cells in a parasitic nematode infection
    Sebastian Rausch
    Department of Molecular Parasitology, Humboldt University Berlin, Philippstr 13, 10115 Berlin, Germany
    Infect Immun 76:1908-19. 2008
    ..In conclusion, our data indicate that small numbers of T(eff) cells have the ability to promote host protective immune responses, even in the presence of T(reg) cells...
  8. pmc Suppression of allergic airway inflammation by helminth-induced regulatory T cells
    Mark S Wilson
    Institute of Immunology and Infection Research, University of Edinburgh, UK
    J Exp Med 202:1199-212. 2005
    ..These data support the contention that helminth infections elicit a regulatory T cell population able to down-regulate allergen induced lung pathology in vivo...
  9. pmc Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection
    De Broski R Herbert
    Research Service, Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45220, USA
    J Exp Med 206:2947-57. 2009
    ....
  10. ncbi Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloCD103- dendritic cells
    Katherine A Smith
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    J Immunol 186:7098-109. 2011
    ..Thus, the proregulatory environment of chronic intestinal helminth infection is associated with the in vivo predominance of a newly defined phenotype of CD11c(lo) tolerogenic DCs...
  11. pmc Proteomic analysis of excretory-secretory products of Heligmosomoides polygyrus assessed with next-generation sequencing transcriptomic information
    Yovany Moreno
    Institute of Parasitology and Centre for Host Parasite Interactions, McGill University, Ste Anne de Bellevue, Quebec, Canada
    PLoS Negl Trop Dis 5:e1370. 2011
    ..polygyrus biology. In addition, the methods and analyses presented here are applicable to study biochemical and molecular aspects of the host-parasite relationship in species for which sequence information is not available...
  12. pmc Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus
    Wojciech Wojciechowski
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunity 30:421-33. 2009
    ..These results show that B cells mediate protection from pathogens not only by presenting antigen and secreting antibody but also by producing cytokines that regulate the quality and magnitude of humoral and cellular immune responses...
  13. ncbi An enteric helminth infection protects against an allergic response to dietary antigen
    Mohamed Elfatih H Bashir
    Mucosal Immunology Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 169:3284-92. 2002
    ..Taken together, these results suggest that helminth-dependent protection against allergic disease involves immunoregulatory mechanisms that block production of allergen-specific IgE...
  14. ncbi Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins
    James P Hewitson
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, UK
    J Proteomics 74:1573-94. 2011
    ..Overall, this study shows that the secretions of H. polygyrus closely parallel those of clinically important GI nematodes, confirming the value of this parasite as a model of helminth infection...
  15. pmc Type 2 innate immunity in helminth infection is induced redundantly and acts autonomously following CD11c(+) cell depletion
    Katherine A Smith
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom
    Infect Immun 80:3481-9. 2012
    ..Thus, while CD11c(high) DCs initiate helminth-specific adaptive immunity, innate type 2 cells are able to mount an autonomous response to the challenge of parasite infection...
  16. pmc Heligmosomoides polygyrus promotes regulatory T-cell cytokine production in the murine normal distal intestine
    Tommy Setiawan
    Division of Gastroenterology 4611 JCP, University of Iowa Hospital and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 1009, USA
    Infect Immun 75:4655-63. 2007
    ..IL-10 is particularly important for limiting the Th1 response. The T-cell origin of these cytokines demonstrates mucosal regulatory T-cell induction...
  17. pmc Cutting edge: in the absence of TGF-β signaling in T cells, fewer CD103+ regulatory T cells develop, but exuberant IFN-γ production renders mice more susceptible to helminth infection
    Lisa A Reynolds
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    J Immunol 189:1113-7. 2012
    ..Hence, overexpression of IFN-γ negatively modulates immunity, and the presence of Helios(+) Tregs may maintain susceptibility on the C57BL/6 background...
  18. ncbi The relative importance of host characteristics and co-infection in generating variation in Heligmosomoides polygyrus fecundity
    L T Luong
    Center for Infectious Disease Dynamics, Penn State University, University Park, PA 16802, USA
    Parasitology 137:1003-12. 2010
    ..We concluded that intrinsic differences between hosts, specifically with regard to sex and breeding condition, contribute relatively more to the variation in worm fecundity than parasite co-infection status...
  19. pmc Inhibition of autoimmune type 1 diabetes by gastrointestinal helminth infection
    Karin A Saunders
    Department of Immunology, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, United Kingdom
    Infect Immun 75:397-407. 2007
    ....
  20. ncbi Effects of intestinal nematodes during lactation: consequences for host morphology, physiology and offspring mass
    Deborah M Kristan
    Department of Biology, University of California, Riverside 92521, USA
    J Exp Biol 205:3955-65. 2002
    ..Other measures of reproductive output were not affected by parasite infection...
  21. ncbi daf-7-related TGF-beta homologues from Trichostrongyloid nematodes show contrasting life-cycle expression patterns
    H J McSorley
    Centre for Immunity, Infection and Evolution, and Institute for Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland
    Parasitology 137:159-71. 2010
    ..The molecular evolution of this gene family in parasitic nematodes has diversified the pre-protein and life-cycle expression patterns of TGF-beta homologues while conserving the structure of the active domain...
  22. ncbi Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice
    David E Elliott
    Department of Internal Medicine, Division of Gastroenterology Hepatology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Eur J Immunol 34:2690-8. 2004
    ..polygyrus inhibits ongoing IL-10(-/-) colitis in part through blocking mucosal Th1 cytokine production. Resolution of inflammation is associated with increased IL-13 production and can be adoptively transferred by MLN T cells...
  23. ncbi IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo
    Anja Fröhlich
    Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology ETH Zurich, Switzerland
    Blood 109:2023-31. 2007
    ..Overall, our data show IL-21 plays a crucial role in supporting polarized Th2 responses in vivo, while appearing superfluous for Th1 and Th17 responses...
  24. pmc Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanisms
    Qian Liu
    Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 S Orange Avenue, Newark, New Jersey 07103, USA
    Infect Immun 77:5347-58. 2009
    ..These findings suggest that infection with H. polygyrus significantly inhibits T1D in NOD mice through CD25- and IL-10-independent mechanisms and also reduces the severity of T1D when administered late after the onset of insulitis...
  25. ncbi Intestinal helminths protect in a murine model of asthma
    Kunihiko Kitagaki
    Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 177:1628-35. 2006
    ..Helminthic colonization appears to protect against asthma and atopic disorders; the regulatory cytokine, IL-10, may be a critical player...
  26. pmc Antibodies and IL-3 support helminth-induced basophil expansion
    Tina Herbst
    Institute of Microbiology, Swiss Federal Institute of Technology, 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 109:14954-9. 2012
    ..polygyrus bakeri, parasite rejection following challenge infection was impaired. These data reveal a role for isotype-switched antibodies in promoting basophil expansion and effector function following helminth infection...
  27. pmc Regulation of type 2 immunity to helminths by mast cells
    Matthew R Hepworth
    Department of Veterinary Medicine, Institute of Immunology, Free University Berlin, Berlin, Germany
    Gut Microbes 3:476-81. 2012
    ..Furthermore, we will discuss these findings in the context of recently described novel innate immune cells, such as type 2 hematopoietic progenitors and type 2 innate lymphoid cells...
  28. ncbi Mechanisms of neonatal mucosal antibody protection
    Nicola L Harris
    Institute of Experimental Immunology, Universitatsspital, Zurich, Switzerland
    J Immunol 177:6256-62. 2006
    ..This immune IgG could either be delivered directly in milk or retrotransported via neonatal Fc receptor from the neonatal serum into the intestinal lumen to exert its protective effect...
  29. ncbi Critical resources that influence habitat selection decisions by gastrointestinal helminth parasites
    M V Sukhdeo
    Cook College, Rutgers University, New Brunswick, NJ 08903, USA
    Int J Parasitol 26:483-98. 1996
    ....
  30. ncbi Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project
    J M Behnke
    School of Biology, University of Nottingham, University Park, Nottingham, UK
    Parasite Immunol 28:85-94. 2006
    ..polygyrus...
  31. ncbi Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): dose-dependent expulsion of adult worms
    M Robinson
    MRC Experimental Parasitology Research Group, University of Nottingham, University Park
    Parasitology 98:115-24. 1989
    ..In some experiments worm loss was clearly evident by weeks 4 and 6. These hybrid strains showed gene complementation in that adult worms were cleared considerably earlier than in parental strains...
  32. pmc Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus
    Lisa A Reynolds
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, EH9 3JT, UK
    Semin Immunopathol 34:829-46. 2012
    ..We discuss the balance between resistance and susceptibility in this model system and highlight new themes in innate and adaptive immunity, immunomodulation, and regulation of responsiveness in helminth infection...
  33. ncbi Heligmosmoides polygyrus fourth stages induce protection against DSS-induced colitis and change opioid expression in the intestine
    K Donskow-Łysoniewska
    Department of Parasitology, University of Warsaw, Warsaw, Poland
    Parasite Immunol 34:536-46. 2012
    ....
  34. ncbi Heligmosomoides polygyrus elicits a dominant nonprotective antibody response directed against restricted glycan and peptide epitopes
    James P Hewitson
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    J Immunol 187:4764-77. 2011
    ....
  35. ncbi Stat6 regulation of in vivo IL-4 responses
    F D Finkelman
    Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 164:2303-10. 2000
    ..Thus, Stat6 signaling enhances primary IL-4 responses that are made as part of a type 0 cytokine response (mixed type 1 and type 2) and is required for normal development or survival of Th2 memory cells...
  36. ncbi Peripheral CD4 T cells rapidly accumulate at the host: parasite interface during an inflammatory Th2 memory response
    Motoko Morimoto
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 172:2424-30. 2004
    ....
  37. pmc Alternatively activated macrophages in intestinal helminth infection: effects on concurrent bacterial colitis
    Meiqian Weng
    Mucosal Immunology Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 179:4721-31. 2007
    ....
  38. ncbi Enteric nematodes induce stereotypic STAT6-dependent alterations in intestinal epithelial cell function
    Kathleen B Madden
    Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 172:5616-21. 2004
    ..These modified responses are dependent on STAT6 and are the result of both direct effects and indirect effects mediated through enteric nerves...
  39. pmc Heligmosomoides polygyrus infection can inhibit colitis through direct interaction with innate immunity
    Long Hang
    Division of Gastroenterology Hepatology, Department of Internal Medicine, Tufts Medical Center, Boston, MA 02111, USA
    J Immunol 185:3184-9. 2010
    ..DCs have an important role in driving both murine and human IBD. Data suggest that phenotypic alternations in mucosal DC function are part of the regulatory process...
  40. pmc Concurrent infection with an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice
    Chien Chang Chen
    Chang Gung University and Chang Gung Children s Hospital, Taoyuan, Taiwan
    Infect Immun 73:5468-81. 2005
    ..We conclude that H. polygyrus coinfection can promote C. rodentium-associated disease and colitis through a STAT 6-mediated immune mechanism...
  41. pmc Characterisation of effector mechanisms at the host:parasite interface during the immune response to tissue-dwelling intestinal nematode parasites
    Nirav Patel
    Department of Medicine, UMDNJ New Jersey Medical School, MSB F639, 185 South Orange Avenue, Newark, NJ 07103, USA
    Int J Parasitol 39:13-21. 2009
    ....
  42. ncbi Impairment of dendritic cell function by excretory-secretory products: a potential mechanism for nematode-induced immunosuppression
    Mariela Segura
    Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada
    Eur J Immunol 37:1887-904. 2007
    ..Together, these results demonstrate that nematode ES impaired DC function and suppressed both Th1 and Th2 adaptive immune responses possibly by inducing regulatory T cells...
  43. pmc Dynamics of CD11c(+) dendritic cell subsets in lymph nodes draining the site of intestinal nematode infection
    Adam Balic
    Institute of Immunology and Infection Research, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Immunol Lett 127:68-75. 2009
    ....
  44. ncbi B cell multitasking is required to control nematode infection
    Kishore R Alugupalli
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Immunity 30:317-9. 2009
    ..2009) demonstrate that in addition to producing antibodies, B cells play pivotal roles in specific-antigen presentation and cytokine production for optimal T helper 2 responses required for protection against Heligmosomoides polygyrus...
  45. ncbi B7-2 is required for the progression but not the initiation of the type 2 immune response to a gastrointestinal nematode parasite
    R J Greenwald
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 162:4133-9. 1999
    ..They further demonstrate that B7-2 interactions are not necessary for the initiation of the type 2 immune response, but are instead required for its progression after the development of effector T cells...
  46. pmc Anti-Inflammatory mechanisms of enteric Heligmosomoides polygyrus infection against trinitrobenzene sulfonic acid-induced colitis in a murine model
    Thomas L Sutton
    Department of Pediatrics, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Infect Immun 76:4772-82. 2008
    ..Similar response patterns could account for the clinical improvement seen in inflammatory bowel disease with helminthic therapy...
  47. ncbi Stage-specific antigens of Nematospiroides dubius Baylis, 1926 (Nematoda: Heligmosomides)
    J H Adams
    Department of Parasitology, University of Queensland, St Lucia, Australia
    J Parasitol 73:1164-8. 1987
    Antigens were identified from Nematospiroides dubius recovered from outbred Quackenbush mice between 4 and 10 days postinoculation (PI)...
  48. ncbi Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): expulsion of adult worms from fast responder syngeneic and hybrid strains of mice
    F N Wahid
    Department of Zoology, University of Nottingham
    Parasitology 98:459-69. 1989
    ..SJL and SWR mice probably have similar if not identical gene combinations at loci which determine a fast responder phenotype, distinguishing them from the other mouse strains which have been studied...
  49. pmc A nonredundant role for IL-21 receptor signaling in plasma cell differentiation and protective type 2 immunity against gastrointestinal helminth infection
    Irah L King
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 185:6138-45. 2010
    ..Our studies demonstrate a selective role for IL-21 in plasma cell differentiation in the context of protective antiparasitic type 2 immunity...
  50. ncbi Immunity to adult Heligmosomoides polygyrus (Nematospiroides dubius): survival or rejection of adult worms following transplantation to mice refractory to larval challenge
    M Robinson
    Department of Zoology, University of Nottingham, England
    J Helminthol 62:221-31. 1988
    ....
  51. pmc C-type lectins from the nematode parasites Heligmosomoides polygyrus and Nippostrongylus brasiliensis
    Yvonne Harcus
    Institute of Immunology and Infection Research, University of Edinburgh, UK
    Parasitol Int 58:461-70. 2009
    ..Hence, live parasites release C-type lectins homologous to some key receptors of the mammalian host immune system, raising the possibility that these products interfere in some manner with immunological recognition or effector function...
  52. ncbi Plasticity demonstrated in the proteome of a parasitic nematode within the intestine of different host strains
    Charly Morgan
    Institute of Biological Sciences, University of Wales, Aberystwyth, Ceredigion, Wales, UK
    Proteomics 6:4633-45. 2006
    ..Proteome plasticity has relevance to the efficiency of future vaccine and drug therapy, and the continued failure of defined antigen vaccines in mammalian populations...
  53. ncbi Concurrent nematode infection and pregnancy induce physiological responses that impair linear growth in the murine foetus
    M R Odiere
    Institute of Parasitology, McGill University Macdonald Campus, 21 111 Lakeshore Road, Ste Anne de Bellevue, QC H9X 3V9, Canada
    Parasitology 137:991-1002. 2010
    ..Infection also reduced foetal crown-rump length which was associated with higher amniotic fluid IL-1 beta...
  54. ncbi Memory Th2 effector cells can develop in the absence of B7-1/B7-2, CD28 interactions, and effector Th cells after priming with an intestinal nematode parasite
    Melinda J Ekkens
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 168:6344-51. 2002
    ..However, humoral immunity is impaired and differentially affected in B7-1/B7-2(-/-) mice and CD28(-/-) mice following H. polygyrus challenge...
  55. ncbi Cellular and serological responses in resistant and susceptible mice exposed to repeated infection with Heligmosomoides polygyrus bakeri
    Jerzy M Behnke
    School of Biology, University of Nottingham, Nottingham, UK
    Parasite Immunol 25:333-40. 2003
    ..These results reflect the activation of predominantly Th2-driven effector mechanisms, that may be associated with host-protective immunity developing under the trickle infection protocol exploited in these experiments...
  56. ncbi Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice
    David M Menge
    International Livestock Research Institute, PO Box 30709, Nairobi, Kenya
    Parasite Immunol 25:341-9. 2003
    ..Some of these QTL map to regions known to harbour genes responsible for the induction of immunological responses to intestinal worms...
  57. ncbi Reduced apoptosis in BALB/c mice infected with Heligmosomoides polygyrus
    M Doligalska
    Department of Parasitology, University of Warsaw, Warsaw, Poland
    Parasite Immunol 29:283-91. 2007
    ..We suggest that immunosuppression provoked by the nematode is not the outcome of parasite-induced apoptosis, but rather results from a hyporesponsiveness experienced by cells during H. polygyrus infection...
  58. ncbi The relative involvement of Th1 and Th2 associated immune responses in the expulsion of a primary infection of Heligmosomoides polygyrus in mice of differing response phenotype
    A Ben-Smith
    Karonga Prevention Study, PO Box 46, Chilumba, Malawi
    J Helminthol 77:133-46. 2003
    ....
  59. ncbi Heligmosomoides polygyrus: excretory/secretory antigens released in vitro by exsheathed third-stage larvae
    P L Ey
    Department of Microbiology and Immunology, University of Adelaide, Australia
    Exp Parasitol 67:210-20. 1988
    ....
  60. ncbi Irradiated larval vaccination and antibody responses evaluated in relation to the expression of immunity to Heligmosomoides polygyrus
    R J Pleass
    Department of Pathology, Ninewells Hospital, Dundee, Scotland
    Parasitol Res 82:445-53. 1996
    ..Moreover, no correlation was found between levels of parasite-specific serum or mucosal IgG, IgG1, IgG2a or IgA and the loss of worms in individual mice...
  61. ncbi CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response
    W C Gause
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 158:4082-7. 1997
    ..polygyrus-inoculated mice, and elevations in both serum IgG1 and IgE levels occur. These results indicate that the specific kind of type 2 immune response determines whether T cell differentiation to IL-4 production is CD28 dependent...
  62. ncbi Depleted intestinal goblet cells and severe pathological changes in SCID mice infected with Heligmosomoides polygyrus
    K Hashimoto
    Department of Medical Zoology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Parasite Immunol 31:457-65. 2009
    ..These results suggest that a functional T-cell response, but not a mast cell response, is necessary for anti-parasite responses, goblet cell function, and maintaining normal mucosal architecture...
  63. ncbi Immunity-mediated regulation of fecundity in the nematode Heligmosomoides polygyrus--the potential role of mast cells
    K Hashimoto
    Department of Medical Zoology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
    Parasitology 137:881-7. 2010
    ..These findings raise the interesting possibility that certain activities of mast cells, either directly or indirectly, regulate parasite fecundity during infection...
  64. ncbi Chasing the genes that control resistance to gastrointestinal nematodes
    J M Behnke
    School of Life and Environmental Sciences, University of Nottingham, University Park NG7 2RD, UK
    J Helminthol 77:99-110. 2003
    ..This information in turn will facilitate targeted breeding to improve resistance in domestic animals and, in human beings, focused application of treatment and control strategies for GI nematodes...
  65. pmc A two-step process for cytokine production revealed by IL-4 dual-reporter mice
    Katja Mohrs
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Immunity 23:419-29. 2005
    ..These data reveal a two-step process for cytokine production: the first generating poised cells that disseminate systemically and the second inducing the rapid production of the cytokine in response to local stimulation...
  66. ncbi The role of TGF-beta in mice infected with Heligmosomoides polygyrus
    M Doligalska
    Department of Parasitology, Institute of Zoology, University of Warsaw, Warsaw, Poland
    Parasite Immunol 28:387-95. 2006
    ..We conclude that H. polygyrus infection suppresses the immune response through pathways involving TGF-beta production or activity and that the Th2 related immune response was not affected by neutralization...
  67. ncbi Dependence of IL-4, IL-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves
    Aiping Zhao
    Nutritional Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, Beltsville, MD 20705, USA
    J Immunol 171:948-54. 2003
    ..Differences in these effects correlate with differences in the relative importance of these cytokines in the expulsion of enteric nematode parasites...
  68. pmc Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production
    David E Elliott
    Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA
    J Immunol 181:2414-9. 2008
    ..Ab-mediated blockade of IL-17 improves colitis in IL-10-deficient mice. Thus, helminth-associated inhibition of IL-17 production is most likely an important mechanism mediating protection from inappropriate intestinal inflammation...
  69. ncbi Gastrointestinal nematode infection interferes with experimental allergic airway inflammation but not atopic dermatitis
    S Hartmann
    Department of Molecular Parasitology, Humboldt University Berlin, Berlin, Germany
    Clin Exp Allergy 39:1585-96. 2009
    ....
  70. ncbi Calreticulin from the intestinal nematode Heligmosomoides polygyrus is a Th2-skewing protein and interacts with murine scavenger receptor-A
    Justyna Rzepecka
    Department of Molecular Parasitology, Humboldt University, Philippstr 13, 10115 Berlin, Germany
    Mol Immunol 46:1109-19. 2009
    ..Hence, our data imply that nematode calreticulin interacts with a mammalian scavenger receptor and at the same time induces a Th2 response...
  71. pmc Helminth-primed dendritic cells alter the host response to enteric bacterial infection
    Chien Chang Chen
    Chang Gung Children s Hospital and Chang Gung University, Taoyuan, Taiwan
    J Immunol 176:472-83. 2006
    ..rodentium was detected. Thus, our results provide evidence to indicate that the H. polygyrus-dependent modulation of the host response to concurrent C. rodentium infection involves IL-10-producing DCs...
  72. ncbi Enhanced protection against Heligmosomoides polygyrus in IL-2 receptor β-chain overexpressed transgenic mice with intestinal mastocytosis
    Masahiro Morimoto
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Japan
    J Vet Med Sci 73:849-51. 2011
    ..These results clearly indicated that mast cells have the ability for to protect against H. polygyrus infection. However, additional studies are required to evaluate protective effector mechanisms against H. polygyrus...
  73. ncbi Heligmosomoides bakeri: a new name for an old worm?
    Jerzy Behnke
    School of Biology, University of Nottingham, Nottingham, UK, NG7 2RD
    Trends Parasitol 26:524-9. 2010
    ..bakeri is the correct name for the species used widely throughout the world as a laboratory research model. Supporting this claim, key evidence is presented demonstrating that H. bakeri and H. polygyrus are two quite distinct species...
  74. ncbi The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus
    Melinda J Ekkens
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 170:384-93. 2003
    ..polygyrus. However, OX40L interactions were not required for serum IgG1 elevations, increases in germinal center formation, and Ag-specific Th2 cell expansion and migration to the B cell zone...
  75. ncbi Molecular evidence that Heligmosomoides polygyrus from laboratory mice and wood mice are separate species
    J Cable
    School of Biosciences, Cardiff University, Cardiff CF10 3TL, UK
    Parasitology 133:111-22. 2006
    ..polygyrus in the recent past following introduction into America. However, we are unable to reject the hypothesis that H. polygyrus and H. bakeri are sister taxa, and it may be that H. polygyrus is polyphyletic or paraphyletic...
  76. ncbi Heligmosomoides polygyrus infection down-regulates eotaxin concentration and CCR3 expression on lung eosinophils in murine allergic pulmonary inflammation
    J Rzepecka
    Department of Parasitology, University of Warsaw, Miecznikowa 1, 02 096 Warsaw, Poland
    Parasite Immunol 29:405-13. 2007
    ..We postulate that attenuation of allergic inflammation during H. polygyrus infection is a consequence of the dichotomy of the immune response in the face of concurrent antigenic challenge...
  77. pmc Role of T cell TGF-beta signaling in intestinal cytokine responses and helminthic immune modulation
    M Nedim Ince
    Department of Internal Medicine, University of Iowa, Iowa City, USA
    Eur J Immunol 39:1870-8. 2009
    ..Thus, T cell TGF-beta signaling is essential for helminthic stimulation of mucosal IL-10 production, helminthic modulation of intestinal IFN-gamma generation and H. polygyrus-mediated suppression of chronic colitis...
  78. pmc Impairment of protective immunity to blood-stage malaria by concurrent nematode infection
    Zhong Su
    McGill Centre for the Study of Host Resistance, Research Institute of McGill University Health Centre, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada
    Infect Immun 73:3531-9. 2005
    ..These results demonstrate that concurrent nematode infection strongly modulates multiple aspects of immunity to blood-stage malaria and consequently impairs the development of protective antimalarial immunity...
  79. ncbi Induction of CD8+ regulatory T cells in the intestine by Heligmosomoides polygyrus infection
    Ahmed Metwali
    Department of Internal Medicine, University of Iowa, Iowa City, USA
    Am J Physiol Gastrointest Liver Physiol 291:G253-9. 2006
    ..Thus H. polygyrus induces a regulatory CD8+ lamina propria T cell that inhibits T cell proliferation and that appears to have a role in control of colitis...
  80. ncbi Cutting edge: the development of IL-4-producing B cells (B effector 2 cells) is controlled by IL-4, IL-4 receptor alpha, and Th2 cells
    David P Harris
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 175:7103-7. 2005
    ....
  81. ncbi Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology Cambridge, Massachusetts 02139, USA
    Nat Med 6:536-42. 2000
    ..Thus, concurrent enteric helminth infection can attenuate gastric atrophy, a premalignant lesion...
  82. ncbi Genetic and immunological adaptation of Heligmosomoides polygyrus in mice
    Z Su
    Department of Parasitology, University of Queensland, Brisbane, Queensland, Australia
    Int J Parasitol 27:653-63. 1997
    ..These results suggest that adaptation of parasites to immunity of the host is associated with reduction of their immunogenicity and is specific to the immune status and genotype of the host to which the parasites have become adapted...
  83. ncbi Systemic dissemination and persistence of Th2 and type 2 cells in response to infection with a strictly enteric nematode parasite
    Katja Mohrs
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 175:5306-13. 2005
    ..These findings have important implications for the design of vaccination strategies because it may be necessary to establish and maintain memory CD4(+) T cells at the potential future site of infection...
  84. pmc Counter-regulatory anti-parasite cytokine responses during concurrent Plasmodium yoelii and intestinal helminth infections in mice
    Gregory S Noland
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Exp Parasitol 119:272-8. 2008
    ..polygyrus=high), but not IL-10. Concurrent malaria infection also suppressed helminth-associated IL-4 responses, indicating that immunologic counter-regulation occurs during co-infection with malaria and intestinal helminths...
  85. doi Animal model of Nippostrongylus brasiliensis and Heligmosomoides polygyrus
    Mali Camberis
    Malaghan Institute of Medical Research, Wellington, New Zealand
    Curr Protoc Immunol . 2003
    ..This chapter describes simple, cost-effective techniques for using and maintaining these easy-to-work-with parasites in the context of a modern laboratory...
  86. pmc Concurrent gastro-intestinal nematode infection does not alter the development of experimental cerebral malaria
    Brian de Souza
    Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Microbes Infect 10:916-21. 2008
    ..Both groups developed cerebral malaria around the same time point. The data suggest that a chronic helminth infection does not affect the development of cerebral malaria in a murine model...
  87. ncbi [Regulation of the immune response in BALb/c mice infected with Heligmosomoides polygyrus]
    Justyna Rzepecka
    Zakładzie Parazytologii Instytutu Zoologii, Wydział Biologii, Uniwersytet Warszawski
    Wiad Parazytol 53:157-9. 2007
    ..From the bibliographic data it may be supposed that calreticulin could mediate the downregulation of lymphocytes proliferation. The fraction with calreticulin stimulated also production of specific IgE...
  88. ncbi Impact of vitamin E or selenium deficiency on nematode-induced alterations in murine intestinal function
    Karla J Au Yeung
    Department of Pediatrics, Walter Reed Army Medical Center, Washington, DC, USA
    Exp Parasitol 109:201-8. 2005
    ..Thus, vitamin E status is an important factor in the physiological response to intestinal nematode infection and may contribute to antioxidant-dependent protective mechanisms in the small intestine...
  89. ncbi Microsatellite analysis reveals that female mice are indiscriminate when choosing infected or dominant males in an arena setting
    K D Ehman
    Institute of Parasitology, McGill University, Macdonald Campus, Ste Anne de Bellevue, QC, Canada H9X 3V9
    Parasitology 129:723-31. 2004
    ..e. DNA analysis versus behavioural observations and/or phenotypic traits), these findings may be further explained by the spatial complexity of the experimental arenas...
  90. ncbi Deficiencies in selenium and/or vitamin E lower the resistance of mice to Heligmosomoides polygyrus infections
    Allen Smith
    Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, Beltsville, MD, USA
    J Nutr 135:830-6. 2005
    ..These results suggest that both Se and VE are required for specific IL-4-related changes in intestinal physiology that promote host protection against H. polygyrus...
  91. ncbi High transmission rates restore expression of genetically determined susceptibility of mice to nematode infections
    M E Scott
    Institute of Parasitology, Macdonald Campus of McGill University, 21 111 Lakeshore Road, Ste Anne de Bellevue, Quebec, Canada H9X 3V9
    Parasitology 132:669-79. 2006
    ..These data indicate that C57BL/6 mice are less able to regulate parasite numbers at high transmission rates compared with lower transmission rates...
  92. ncbi Heligmosomoides polygyrus induces TLR4 on murine mucosal T cells that produce TGFbeta after lipopolysaccharide stimulation
    M Nedim Ince
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    J Immunol 176:726-9. 2006
    ..Thus, during helminth infection, LPS challenge induces mucosal T cells to make TGFbeta through a TLR4-dependent process without promoting synthesis of proinflammatory cytokines...
  93. pmc Reduced protective efficacy of a blood-stage malaria vaccine by concurrent nematode infection
    Zhong Su
    Research Institute of McGill University Health Centre, Room L11 409, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada
    Infect Immun 74:2138-44. 2006
    ..These results demonstrate that concurrent nematode infection strongly modulates immune responses induced by an experimental malaria vaccine and consequently suppresses the protective efficacy of the vaccine against malaria challenge...
  94. ncbi Contrasting effects of acute and chronic gastro-intestinal helminth infections on a heterologous immune response in a transgenic adoptive transfer model
    A Boitelle
    Department of Immunology, University of Strathclyde, The Todd Wing, SIBS, 27 Taylor Street, Glasgow G4 0NR, UK
    Int J Parasitol 35:765-75. 2005
    ..suum parasite extracts were directly mixed with the OVA during immunisation in our previous studies...
  95. ncbi [Apoptosis in the regulation of immune response in mice infected with Heligmosomoides polygyrus]
    Katarzyna Donskow
    Zakład Parazytologii, Instytut Zoologii, Wydział Biologii, Uniwersytet Warszawski, Warszawa
    Wiad Parazytol 50:519-22. 2004
    ..Interleukine 5 and IL-6 concentrations increased on time when apoptosis was reduced. No changes in the level of IL-12 were related to intensity of proliferation or apoptosis in both examined strains of mice...
  96. ncbi Maternal and direct effects of the intestinal nematode Heligmosomoides polygyrus on offspring growth and susceptibility to infection
    Deborah M Kristan
    Department of Biology, University of California, Riverside 92521, USA
    J Exp Biol 205:3967-77. 2002
    ..polygyrus has both maternal and direct effects that induce physiological changes in growing mice sufficient to alter host growth trajectories, morphology and susceptibility to parasite infection...
  97. ncbi Aerobic performance of wild-derived house mice does not change with cold exposure or intestinal parasite infection
    Deborah M Kristan
    Department of Biology, University of California, Riverside, California 92521, USA
    Physiol Biochem Zool 77:440-9. 2004
    ..polygyrus) demands and, therefore, wild-derived mice respond to these demands without incurring potential costs associated with changes in aerobic performance...
  98. ncbi Screening for immunomodulatory proteins of the intestinal parasitic nematode Heligmosomoides polygyrus
    J Rzepecka
    Department of Parasitology, University of Warsaw, 02096 Warsaw, Poland
    Parasite Immunol 28:463-72. 2006
    ..Single proteins of fraction 9 were analysed by mass spectrometry. These data suggest that antigens that are recognised by IgE antibodies might play an important role in immunomodulation exerted by nematode infections...
  99. ncbi Response of laboratory-adapted human hookworm and other nematodes to ivermectin
    G R Rajasekariah
    Section of Intestinal Helminths, Hindustan Ciba Geigy Research Centre, Bombay, India
    Ann Trop Med Parasitol 80:615-21. 1986
    ..Tests were also carried out with other rodent parasites, namely Nematospiroides dubius, Strongyloides ratti and Trichuris muris. Doses as low as 0.3 mg kg-1 X 1 completely eliminated adult N...
  100. ncbi Heligmosomoides bakeri: a model for exploring the biology and genetics of resistance to chronic gastrointestinal nematode infections
    J M Behnke
    School of Biology, University of Nottingham, University Park, Nottingham, UK
    Parasitology 136:1565-80. 2009
    ..Originally, the name conferred on the organism in the early 20th century was Nematospiroides dubius, but this was dropped in favour of Heligmosomoides polygyrus, and then more recently H...
  101. ncbi Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): the capacity of adult worms to survive following transplantation to recipient mice
    J M Behnke
    Department of Zoology, University of Nottingham
    Parasitology 95:569-81. 1987
    Chronic primary infections with Heligmosomoides polygyrus (Nematospiroides dubius) are still relatively poorly documented, particularly in relation to the role of host resistance in limiting worm survival...

Research Grants11

  1. DIFFERENT IMBALANCES OF CYTOKINES IN NEMATODE INFECTIONS
    Norman Reed; Fiscal Year: 1992
    ..brasiliensis (Nb) and Trichinella spiralis (Ts) cause striking intestinal mastocytosis; by contrast, Nematospiroides dubius (Nd) not only fails to cause mastocytosis but also inhibits the development of mastocytosis following ..
  2. Regulation of Inflammation by Somatostatin via SSTR 2
    David Elliott; Fiscal Year: 2006
    ..The results of these studies will provide rationale for novel therapeutic treatment of IBD and other inflammatory diseases. ..
  3. Dendritic Cell Response to Microsporidians
    IMTIAZ AHMED KHAN; Fiscal Year: 2010
    ..This specific aim will determine if aging results in poor innate DC response to E. cuniculi and whether IL-15 can restores ARC function. ..
  4. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    James Fox; Fiscal Year: 2006
    ....
  5. Microecology-murine gut-initiation & progression of IBD
    James Fox; Fiscal Year: 2005
    ..prior and subsequent to oral vaccination with Helicobacter spp. antigens and mucosal adjuvants, elucidate how these vaccine strategies influence microflora dynamics and impact gut cytokine responses. ..
  6. HUS Pathogenesis & clinical Outcome in an in vivo model
    James Fox; Fiscal Year: 2008
    ..We will use this model to study the pathogenesis of HUS and importantly to develop therapeutic regimens to prevent and treat EHEC disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  7. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2009
    ..pylori pathogenesis and specifically evaluate the role of regulatory T cells in limiting H. pylori-induced gastric pathology. ..
  8. B1B lymphocytes generate T cell-independent memory
    KISHORE ALUGUPALLI; Fiscal Year: 2009
    ..Understanding the basis for the longevity of the Tl protective responses conferred by B1b cells will provide novel approaches to generate effective vaccines against pathogens expressing Tl antigens. ..
  9. Helicobacter induced hepatitis and tumorigenesis
    James Fox; Fiscal Year: 2009
    ..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..
  10. Encephalitozoan cuniculi-Host immunity and pathogenesis
    Imtiaz Khan; Fiscal Year: 2008
    ..cuniculi infected mice persist for a long period. Development and mechanism of persistence of long-term antigen specific IELs (memory IELs) in the infected animals will be evaluated. [unreadable] [unreadable]..