strongylocentrotus purpuratus

Summary

Summary: A species of SEA URCHINS in the family Strongylocentrotidae found on the Pacific coastline from Alaska to Mexico. This species serves as a major research model for molecular developmental biology and other fields.

Top Publications

  1. pmc Gene structure in the sea urchin Strongylocentrotus purpuratus based on transcriptome analysis
    Qiang Tu
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Genome Res 22:2079-87. 2012
  2. pmc The genome of the sea urchin Strongylocentrotus purpuratus
    Erica Sodergren
    Science 314:941-52. 2006
  3. pmc SpBase: the sea urchin genome database and web site
    R Andrew Cameron
    Center for Computational Regulatory Genomics, Beckman Institute 139 74, California Institute of Technology, Pasadena, CA 91104, USA
    Nucleic Acids Res 37:D750-4. 2009
  4. pmc Evolutionary analysis of the well characterized endo16 promoter reveals substantial variation within functional sites
    James P Balhoff
    Department of Biology, Duke University, Durham, NC 27708, USA
    Proc Natl Acad Sci U S A 102:8591-6. 2005
  5. pmc Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking
    Margarida Ruas
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK
    Curr Biol 20:703-9. 2010
  6. ncbi Role of protein kinase C, G-protein coupled receptors, and calcium flux during metamorphosis of the sea urchin Strongylocentrotus purpuratus
    G Amador-Cano
    Instituto de Investigaciones Oceanológicas, Universidad Autonoma de Baja California, Apartado Postal 453, Ensenada, B C México 22800
    Biol Bull 210:121-31. 2006
  7. pmc Restriction Site Tiling Analysis: accurate discovery and quantitative genotyping of genome-wide polymorphisms using nucleotide arrays
    Melissa H Pespeni
    Department of Biology, Stanford University, Hopkins Marine Station, Oceanview Blvd Pacific Grove, CA 93950, USA
    Genome Biol 11:R44. 2010
  8. pmc Genetics of gene expression responses to temperature stress in a sea urchin gene network
    Daniel E Runcie
    Department of Biology, Duke University, Durham, NC 27708, USA
    Mol Ecol 21:4547-62. 2012
  9. ncbi Natural variation and the capacity to adapt to ocean acidification in the keystone sea urchin Strongylocentrotus purpuratus
    Morgan W Kelly
    Department of Ecology, University of California, Santa Barbara, CA 93106 9620, USA
    Glob Chang Biol 19:2536-46. 2013
  10. ncbi Population genetics of cis-regulatory sequences that operate during embryonic development in the sea urchin Strongylocentrotus purpuratus
    David Garfield
    Department of Biology and Institute for Genome Sciences and Policy, Duke University, Box 90338, Durham, NC 27708, USA
    Evol Dev 14:152-67. 2012

Detail Information

Publications213 found, 100 shown here

  1. pmc Gene structure in the sea urchin Strongylocentrotus purpuratus based on transcriptome analysis
    Qiang Tu
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Genome Res 22:2079-87. 2012
    A comprehensive transcriptome analysis has been performed on protein-coding RNAs of Strongylocentrotus purpuratus, including 10 different embryonic stages, six feeding larval and metamorphosed juvenile stages, and six adult tissues...
  2. pmc The genome of the sea urchin Strongylocentrotus purpuratus
    Erica Sodergren
    Science 314:941-52. 2006
    We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology...
  3. pmc SpBase: the sea urchin genome database and web site
    R Andrew Cameron
    Center for Computational Regulatory Genomics, Beckman Institute 139 74, California Institute of Technology, Pasadena, CA 91104, USA
    Nucleic Acids Res 37:D750-4. 2009
    ..served from the databases emerges from the draft genomic sequence of the purple sea urchin, Strongylocentrotus purpuratus and includes sequence data and genomic resource descriptions for other members of the echinoderm clade ..
  4. pmc Evolutionary analysis of the well characterized endo16 promoter reveals substantial variation within functional sites
    James P Balhoff
    Department of Biology, Duke University, Durham, NC 27708, USA
    Proc Natl Acad Sci U S A 102:8591-6. 2005
    ....
  5. pmc Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking
    Margarida Ruas
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK
    Curr Biol 20:703-9. 2010
    ..We propose that NAADP regulates endolysosomal Ca(2+) storage and release via TPCs and coordinates endoplasmic reticulum Ca(2+) release in a role that impacts on Ca(2+) signaling in health and disease [6]...
  6. ncbi Role of protein kinase C, G-protein coupled receptors, and calcium flux during metamorphosis of the sea urchin Strongylocentrotus purpuratus
    G Amador-Cano
    Instituto de Investigaciones Oceanológicas, Universidad Autonoma de Baja California, Apartado Postal 453, Ensenada, B C México 22800
    Biol Bull 210:121-31. 2006
    ..In addition, according to the results obtained with G-protein inhibitors, the GPCRs may be shared between the artificial (KCl) and natural (biofilm) inducers...
  7. pmc Restriction Site Tiling Analysis: accurate discovery and quantitative genotyping of genome-wide polymorphisms using nucleotide arrays
    Melissa H Pespeni
    Department of Biology, Stanford University, Hopkins Marine Station, Oceanview Blvd Pacific Grove, CA 93950, USA
    Genome Biol 11:R44. 2010
    ..It is highly accurate and free from ascertainment bias. We apply the approach to uncover genomic differentiation in the purple sea urchin...
  8. pmc Genetics of gene expression responses to temperature stress in a sea urchin gene network
    Daniel E Runcie
    Department of Biology, Duke University, Durham, NC 27708, USA
    Mol Ecol 21:4547-62. 2012
    ..of additive genetic variation to gene expression during development of the purple sea urchin, Strongylocentrotus purpuratus, under increased temperatures that model realistic climate change scenarios...
  9. ncbi Natural variation and the capacity to adapt to ocean acidification in the keystone sea urchin Strongylocentrotus purpuratus
    Morgan W Kelly
    Department of Ecology, University of California, Santa Barbara, CA 93106 9620, USA
    Glob Chang Biol 19:2536-46. 2013
    ..Here, we measure the capacity of the ecologically important purple sea urchin Strongylocentrotus purpuratus to adapt to OA, using a breeding experiment to estimate additive genetic variance for larval size (an ..
  10. ncbi Population genetics of cis-regulatory sequences that operate during embryonic development in the sea urchin Strongylocentrotus purpuratus
    David Garfield
    Department of Biology and Institute for Genome Sciences and Policy, Duke University, Box 90338, Durham, NC 27708, USA
    Evol Dev 14:152-67. 2012
    ..FoxB, HE, SM30 a, and SM50) that function during the early development of the purple sea urchin, Strongylocentrotus purpuratus. Quantitative and qualitative measures of segregating variation are not conspicuously different ..
  11. ncbi Spatial vision in the purple sea urchin Strongylocentrotus purpuratus (Echinoidea)
    D Yerramilli
    Biology Department, Duke University, Durham, NC 27708, USA
    J Exp Biol 213:249-55. 2010
    ..acuity that appears to be mediated by their spines screening off-axis light suggests that the urchin Strongylocentrotus purpuratus, with its higher spine density, may have even more acute spatial vision...
  12. ncbi Simultaneous positive and negative frequency-dependent selection on sperm bindin, a gamete recognition protein in the sea urchin Strongylocentrotus purpuratus
    Don R Levitan
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
    Evolution 64:785-97. 2010
    ..We explored how variation in sperm bindin influences reproductive success of the sea urchin Strongylocentrotus purpuratus during group spawning in the sea...
  13. ncbi The larval stages of the sea urchin, Strongylocentrotus purpuratus
    M Meighan Smith
    Biology Department, Mills College, Oakland, California 94613, USA
    J Morphol 269:713-33. 2008
    The adult body plan of Strongylocentrotus purpuratus is established within the imaginal rudiment during the larval stages...
  14. ncbi Highly variable immune-response proteins (185/333) from the sea urchin, Strongylocentrotus purpuratus: proteomic analysis identifies diversity within and between individuals
    Nolwenn M Dheilly
    Department of Biological Sciences, Macquarie University, North Ryde, New South Wales, Australia
    J Immunol 182:2203-12. 2009
    185/333 genes and transcripts from the purple sea urchin, Strongylocentrotus purpuratus, predict high levels of amino acid diversity within the encoded proteins...
  15. ncbi Evolutionary analysis of the cis-regulatory region of the spicule matrix gene SM50 in strongylocentrotid sea urchins
    Jenna Walters
    Department of Biology, Denison University, Granville, OH 43023, USA
    Dev Biol 315:567-78. 2008
    ..of SM50, which has already been characterized to a considerable extent in the purple sea urchin, Strongylocentrotus purpuratus. We have isolated the cis-regulatory region from 15 individuals of S...
  16. pmc Genome-wide polymorphisms show unexpected targets of natural selection
    Melissa H Pespeni
    Department of Biology, Hopkins Marine Station, Stanford University, Oceanview Boulevard, Pacific Grove, CA 93950, USA
    Proc Biol Sci 279:1412-20. 2012
    ..we performed one of the first genome-wide surveys in a marine species, comparing purple sea urchins, Strongylocentrotus purpuratus, from two distant locations along the species' wide latitudinal range...
  17. ncbi Discovery of a second SALMFamide gene in the sea urchin Strongylocentrotus purpuratus reveals that L-type and F-type SALMFamide neuropeptides coexist in an echinoderm species
    Matthew L Rowe
    Queen Mary University of London, School of Biological and Chemical Sciences, Mile End Road, London, E1 4NS, UK
    Mar Genomics 3:91-7. 2010
    ..Here we have obtained a new insight on this issue with the discovery that in the sea urchin Strongylocentrotus purpuratus there are two SALMFamide genes...
  18. ncbi Apoptosis in early development of the sea urchin, Strongylocentrotus purpuratus
    Rebecca Vega Thurber
    Stanford University, Hopkins Marine Station, 120 Oceanview Blvd, Pacific Grove, CA 93950, USA
    Dev Biol 303:336-46. 2007
    ..cell death is infrequent and not obligatory during early embryogenesis of the purple sea urchin, Strongylocentrotus purpuratus. During the first 30 h of urchin development, fewer than 20% of embryos exhibit any cell death...
  19. ncbi Cis-regulatory analysis of the sea urchin pigment cell gene polyketide synthase
    Cristina Calestani
    Department of Biology, University of Central Florida, Orlando, FL 32816, USA
    Dev Biol 340:249-55. 2010
    The Strongylocentrotus purpuratus polyketide synthase gene (SpPks) encodes an enzyme required for the biosynthesis of the larval pigment echinochrome...
  20. ncbi Ecological role of purple sea urchins
    John S Pearse
    Long Marine Laboratory, University of California, Santa Cruz, 100 Shaffer Road, Santa Cruz, CA 95060, USA
    Science 314:940-1. 2006
    ..Their grazing limits algal biomass, and they are preyed upon by many predators. Purple sea urchins (Strongylocentrotus purpuratus) are among the best studied species...
  21. ncbi Sp185/333: a novel family of genes and proteins involved in the purple sea urchin immune response
    Julie Ghosh
    Department of Biological Sciences, George Washington University, Washington, DC, USA
    Dev Comp Immunol 34:235-45. 2010
    ..system of genes, messages and proteins are expressed in the coelomocytes of the purple sea urchin, Strongylocentrotus purpuratus, and is an extraordinary example of diversification of a putative innate immune response system in an ..
  22. ncbi Activation of multidrug efflux transporter activity at fertilization in sea urchin embryos (Strongylocentrotus purpuratus)
    Amro M Hamdoun
    Hopkins Marine Station, Stanford University, 120 Oceanview Boulevard, Pacific Grove, CA 93950, USA
    Dev Biol 276:452-62. 2004
    ..In addition, inhibition of mrp activity with MK571 alone retards mitosis indicating that mrp-like activity may also be required for early cell divisions...
  23. pmc What is the core oscillator in the speract-activated pathway of the Strongylocentrotus purpuratus sperm flagellum?
    Luis U Aguilera
    Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Unidad Monterrey, Parque de Investigación e Innovación Tecnológica, Apodaca, Mexico
    Biophys J 102:2481-8. 2012
    ..from a mathematical modeling perspective, that the reported speract-activated signaling pathway in Strongylocentrotus purpuratus (speract being a sperm-activating peptide specific to this species) has the necessary elements to ..
  24. ncbi Early developmental gene regulation in Strongylocentrotus purpuratus embryos in response to elevated CO₂ seawater conditions
    Latisha M Hammond
    Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, CA 93106 9620, USA
    J Exp Biol 215:2445-54. 2012
    ..and the initiation of spiculogenesis, two crucial developmental processes in the purple sea urchin, Strongylocentrotus purpuratus. Embryos were reared at the current, accepted oceanic CO(2) concentration of 380 microatmospheres (μ..
  25. ncbi Shotgun proteomics of coelomic fluid from the purple sea urchin, Strongylocentrotus purpuratus
    Nolwenn M Dheilly
    Department of Biological Sciences, Macquarie University, North Ryde, NSW 2109, Australia
    Dev Comp Immunol 40:35-50. 2013
    ..However, based on this dataset, the expression of TLRs, NLRs and fibrinogen domain containing proteins in coelomic fluid and coelomocytes could not be verified...
  26. pmc Effects of seawater acidification on cell cycle control mechanisms in Strongylocentrotus purpuratus embryos
    Sean P Place
    Department of Biological Sciences and The Environment and Sustainability Program, University of South Carolina, Columbia, South Carolina, United States of America
    PLoS ONE 7:e34068. 2012
    ..We grew embryos of the purple sea urchin, Strongylocentrotus purpuratus, in seawater artifically buffered to a pH of ∼7.0, 7.5, and 8.0 by CO(2) infusion...
  27. ncbi Development under elevated pCO2 conditions does not affect lipid utilization and protein content in early life-history stages of the purple sea urchin, Strongylocentrotus purpuratus
    Paul G Matson
    Department of Ecology, Evolution and Marine Biology, University of California Santa Barbara, CA 93106 9620, USA
    Biol Bull 223:312-27. 2012
    ..We examined the biochemical and morphological responses of Strongylocentrotus purpuratus during early development under ecologically relevant levels of pCO(2) (365, 1030, and 1450 μatm) that ..
  28. pmc Histamine is a modulator of metamorphic competence in Strongylocentrotus purpuratus (Echinodermata: Echinoidea)
    Josh Sutherby
    University of Guelph, Integrative Biology, Guelph, ON N1G 2 W1, Canada
    BMC Dev Biol 12:14. 2012
    ..Here we test the premise that HA functions as a developmental modulator of metamorphic competence in the sea urchin Strongylocentrotus purpuratus.
  29. pmc The sea urchin animal pole domain is a Six3-dependent neurogenic patterning center
    Zheng Wei
    National Institute for Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Development 136:1179-89. 2009
    ....
  30. ncbi Expression of Spgatae, the Strongylocentrotus purpuratus ortholog of vertebrate GATA4/5/6 factors
    Pei Yun Lee
    Division of Biology, California Institute of Technology, 1200 E California Blvd, Mail Code 156 29, Pasadena, CA 91125, USA
    Gene Expr Patterns 5:161-5. 2004
    ..Towards the end of embryogenesis, expression in the hindgut decreases. The terminal pattern of expression is in midgut plus coelomic pouches...
  31. ncbi Transcriptomic response of sea urchin larvae Strongylocentrotus purpuratus to CO2-driven seawater acidification
    Anne E Todgham
    Department of Ecology, Evolution, and Marine Biology, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    J Exp Biol 212:2579-94. 2009
    ..of the physiological response of larvae of a calcifying marine invertebrate, the purple sea urchin, Strongylocentrotus purpuratus, to CO(2)-driven seawater acidification...
  32. pmc Real-time analysis of the role of Ca(2+) in flagellar movement and motility in single sea urchin sperm
    Christopher D Wood
    Department of Developmental Genetics and Molecular Physiology, Institute of Biotechnology, National Autonomous University of Mexico, Cuernavaca, Morelos 62210, Mexico
    J Cell Biol 169:725-31. 2005
    ..Instead we propose a new model whereby flagella bending is increased by Ca(2+) flux through the nimodipine-sensitive pathway, and is unaffected by [Ca(2+)]i increases through alternative pathways...
  33. pmc Global regulatory logic for specification of an embryonic cell lineage
    Paola Oliveri
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 105:5955-62. 2008
    ..The GRN precisely predicts gene expression responses and provides a coherent explanation of the biology of specification...
  34. ncbi Specification of ectoderm restricts the size of the animal plate and patterns neurogenesis in sea urchin embryos
    Shunsuke Yaguchi
    Department of Biology, University of Victoria, POB 3020, STN CSC, Victoria, BC, V8W 3N5, Canada
    Development 133:2337-46. 2006
    ..Like other metazoans, echinoderms appear to have a phase of neural development during which the specification of ectoderm restricts and patterns neurogenesis...
  35. ncbi Marine invertebrate genome sequences and our evolving understanding of animal immunity
    Jonathan P Rast
    Department of Medical Biophysics, University of Toronto, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Rm S126B, Toronto, Ontario M4N 3M5, Canada
    Biol Bull 214:274-83. 2008
    ..In this review we summarize these findings with particular attention toward immunity in Strongylocentrotus purpuratus, the purple sea urchin, and outline the changing perspective on the evolution of deuterostome immunity.
  36. pmc Genomic insights into the immune system of the sea urchin
    Jonathan P Rast
    Sunnybrook Research Institute and Department of Medical Biophysics, University of Toronto, 2075 Bayview Avenue, Room S 126B, Toronto, Ontario M4N 3M5, Canada
    Science 314:952-6. 2006
    ..The findings serve to underscore the dynamic utilization of receptors and the complexity of immune recognition that may be basal for deuterostomes and predicts features of the ancestral bilaterian form...
  37. ncbi Sp-tetraKCNG: A novel cyclic nucleotide gated K(+) channel
    Blanca Estela Galindo
    Depto de Genética del Desarrollo y Fisiología Molecular del Instituto de Biotecnología, Universidad Nacional Autonoma de Mexico, Apdo Postal 510 3, Cuernavaca, Morelos 62271, Mexico
    Biochem Biophys Res Commun 354:668-75. 2007
    ..cGMP-regulated, tetrameric, K(+) selective channel (Sp-tetraKCNG) was discovered in the sea urchin Strongylocentrotus purpuratus. The Sp-tetraKCNG is a single polypeptide made of four KCNG domains similar to voltage-dependent Na(+) ..
  38. pmc An agent-based model contrasts opposite effects of dynamic and stable microtubules on cleavage furrow positioning
    Garrett M Odell
    Center for Cell Dynamics, University of Washington, Friday Harbor, WA 98250, USA
    J Cell Biol 183:471-83. 2008
    ..Because stabilized microtubules aim statistically at the equatorial spindle midplane, that is where centralspindlin accumulates to stimulate furrow formation...
  39. ncbi The transcriptome of the sea urchin embryo
    Manoj P Samanta
    Systemix Institute, Los Altos, CA 94024, USA
    Science 314:960-2. 2006
    The sea urchin Strongylocentrotus purpuratus is a model organism for study of the genomic control circuitry underlying embryonic development. We examined the complete repertoire of genes expressed in the S...
  40. pmc A microtubule-dependent zone of active RhoA during cleavage plane specification
    William M Bement
    Center for Cell Dynamics, Friday Harbor Laboratories, University of Washington, Friday Harbor, WA 98250, USA
    J Cell Biol 170:91-101. 2005
    ..We conclude that microtubules specify the cytokinetic apparatus via a dynamic zone of local RhoA activity...
  41. pmc Stable and dynamic microtubules coordinately shape the myosin activation zone during cytokinetic furrow formation
    Victoria E Foe
    The Center for Cell Dynamics, University of Washington, Friday Harbor, WA 98250, USA
    J Cell Biol 183:457-70. 2008
    ..We conclude that opposite effects of stable versus dynamic microtubules focuses myosin activation to the cell equator during cytokinesis...
  42. ncbi The 185/333 gene family is a rapidly diversifying host-defense gene cluster in the purple sea urchin Strongylocentrotus purpuratus
    K M Buckley
    Department of Biological Sciences, George Washington University, Washington, DC 20052, USA
    J Mol Biol 379:912-28. 2008
    ..These results add to the growing body of evidence suggesting that invertebrate immune systems are not simple and static, but are dynamic and highly complex, and may employ group-specific mechanisms for diversification...
  43. pmc Ca(2+) signaling occurs via second messenger release from intraorganelle synthesis sites
    Lianne C Davis
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom
    Curr Biol 18:1612-8. 2008
    ..This represents a novel signaling mechanism whereby an extracellular stimulus increases the concentration of a second messenger by promoting messenger transport from intraorganelle synthesis sites to the cytosol...
  44. pmc An ancient evolutionary origin of the Rag1/2 gene locus
    Sebastian D Fugmann
    Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 103:3728-33. 2006
    ..a closely linked pair of genes, SpRag1L and SpRag2L, from an invertebrate, the purple sea urchin (Strongylocentrotus purpuratus) with similarity in both sequence and genomic organization to the vertebrate Rag1 and Rag2 genes...
  45. ncbi The sea urchin genome: where will it lead us?
    Eric H Davidson
    Division of Biology, 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Science 314:939-40. 2006
    ..The sequence will accelerate progress toward complete understanding of the genomic regulatory system that controls developmental specification and morphogenetic function, thus illuminating basic developmental process in all animals...
  46. ncbi Unexpected diversity displayed in cDNAs expressed by the immune cells of the purple sea urchin, Strongylocentrotus purpuratus
    David P Terwilliger
    Department of Biological Sciences, George Washington University, Washington, District of Columbia 20052, USA
    Physiol Genomics 26:134-44. 2006
    ..Two 185/333 genes, identified in the partially assembled Strongylocentrotus purpuratus genome, have two exons...
  47. ncbi cis-Regulatory inputs of the wnt8 gene in the sea urchin endomesoderm network
    Takuya Minokawa
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Dev Biol 288:545-58. 2005
    ..Here, the modular cis-regulatory system of the wnt8 gene of Strongylocentrotus purpuratus was characterized functionally, and shown to respond to blockade of both Blimp1/Krox and Tcf1/beta-..
  48. ncbi SpTie1/2 is expressed in coelomocytes, axial organ and embryos of the sea urchin Strongylocentrotus purpuratus, and is an orthologue of vertebrate Tie1 and Tie2
    Margaret E Stevens
    Department of Biology, Ripon College, Ripon Wisconsin, United States
    Dev Comp Immunol 34:884-95. 2010
    ..We speculate that SpTie1/2 may be involved in the proliferation of sea urchin immune cells in both adults and embryos...
  49. pmc Distinctive expression patterns of 185/333 genes in the purple sea urchin, Strongylocentrotus purpuratus: an unexpectedly diverse family of transcripts in response to LPS, beta-1,3-glucan, and dsRNA
    David P Terwilliger
    Department of Biological Sciences, George Washington University, Washington, DC, USA
    BMC Mol Biol 8:16. 2007
    ..Individual sea urchins were challenged with pathogen associated molecular patterns (PAMPs) (lipopolysaccharide, beta-1,3-glucan, or double stranded RNA), and changes in the 185/333 message repertoire were followed over time...
  50. ncbi Substratum cavities affect growth-plasticity, allometry, movement and feeding rates in the sea urchin Strongylocentrotus purpuratus
    J C Hernandez
    Department of Biology, 800 Lancaster Avenue, Villanova University, PA 19085, USA
    J Exp Biol 213:520-5. 2010
    ..the influence of rock cavities, or pits, on the growth dynamics and behavior of the purple sea urchin, Strongylocentrotus purpuratus. In a paired-designed, laboratory experiment, sea urchins were assigned to sandstone blocks that were ..
  51. ncbi Neurosensory and neuromuscular organization in tube feet of the sea urchin Strongylocentrotus purpuratus
    Cavit Agca
    Department of Ophthalmology, University of Zurich, Zurich 8091, Switzerland
    J Comp Neurol 519:3566-79. 2011
    ..Recently, we showed that the Strongylocentrotus purpuratus genome contains orthologs of many mammalian retinal genes and that these genes are expressed in tube ..
  52. ncbi Localization and diversity of 185/333 proteins from the purple sea urchin--unexpected protein-size range and protein expression in a new coelomocyte type
    Virginia Brockton
    George Washington University, Department of Biological Sciences, Washington, DC 20052, USA
    J Cell Sci 121:339-48. 2008
    ..The diversity of the 185/333 proteins, their expression in response to immune challenge, and their cellular localization suggests this protein family and the small phagocytes have an important immunological role in the sea urchin...
  53. pmc Extraordinary diversity among members of the large gene family, 185/333, from the purple sea urchin, Strongylocentrotus purpuratus
    Katherine M Buckley
    George Washington University, Department of Biological Sciences, Washington, DC 20052, USA
    BMC Mol Biol 8:68. 2007
    ..The work presented here indicates that this family of transcripts is derived from an unexpectedly diverse gene family...
  54. ncbi Constitutive expression and alternative splicing of the exons encoding SCRs in Sp152, the sea urchin homologue of complement factor B. Implications on the evolution of the Bf/C2 gene family
    David P Terwilliger
    Department of Biological Sciences, The George Washington University, Lisner Hall 340, 2023 G Street, NW, Washington, DC 20052, USA
    Immunogenetics 56:531-43. 2004
    The purple sea urchin, Strongylocentrotus purpuratus, possesses a non-adaptive immune system including elements homologous to C3 and factor B (Bf) of the vertebrate complement system...
  55. ncbi Expression and function of blimp1/krox, an alternatively transcribed regulatory gene of the sea urchin endomesoderm network
    Carolina B Livi
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Dev Biol 293:513-25. 2006
    The blimp1/krox gene of Strongylocentrotus purpuratus, formerly krox1, encodes zinc finger transcription factors which play a central role in both early and late endomesoderm specification...
  56. ncbi Structure, expression, and transcriptional regulation of the Strongylocentrotus franciscanus spec gene family encoding intracellular calcium-binding proteins
    Jeffrey T Villinski
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 117, Houston 77030, USA
    Dev Genes Evol 215:410-22. 2005
    ..Genes of the spec family from Strongylocentrotus purpuratus and Lytechinus pictus have identical patterns of aboral ectoderm-specific expression but exhibit ..
  57. ncbi cis-Regulatory control of cyclophilin, a member of the ETS-DRI skeletogenic gene battery in the sea urchin embryo
    Gabriele Amore
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Dev Biol 293:555-64. 2006
    The Strongylocentrotus purpuratus cyclophilin1 gene (Sp-cyp1) is expressed exclusively in skeletogenic mesenchyme cells of the embryo, beginning in the micromere lineage of the early blastula stage and continuing after gastrulation ..
  58. ncbi Plasma membrane calcium ATPase is concentrated in the head of sea urchin spermatozoa
    Herath Jayantha Gunaratne
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0202, USA
    J Cell Physiol 207:413-9. 2006
    ..Thus, the sperm head and flagellum localize different gene products, both functioning to keep intracellular Ca2+ low, while the sperm swims in seawater containing 10 mM Ca2+...
  59. ncbi Tandem mass spectrometry identifies proteins phosphorylated by cyclic AMP-dependent protein kinase when sea urchin sperm undergo the acrosome reaction
    Yi Hsien Su
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0202, USA
    Dev Biol 285:116-25. 2005
    ..Based on their identities and localizations in sperm head and flagellum, the putative functions of these proteins in sperm physiology and AR induction are discussed...
  60. ncbi Identification of cis-regulatory elements involved in transcriptional regulation of the sea urchin SpFoxB gene
    Elizabeth Sharon Fung
    Department of Biology, University of South Florida, Tampa, FL 33620, USA
    Dev Growth Differ 47:461-70. 2005
    ..Deletion of the GATA/YY1 sites causes a significant decrease in transcription. The DNA binding site of the SpFoxB protein has been determined, and Fox binding sites are found within the 5' UTR of SpFoxB...
  61. ncbi Septate junctions mediate the barrier to paracellular permeability in sea urchin embryos
    Erin M Itza
    Department of Zoology, Miami University, Oxford, Ohio, USA
    Zygote 13:255-64. 2005
    ..The results provide evidence that septate junctions mediate the barrier to paracellular permeability in sea urchin embryos...
  62. ncbi Unusual gene order and organization of the sea urchin hox cluster
    R Andrew Cameron
    Division of Biology and the Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA
    J Exp Zool B Mol Dev Evol 306:45-58. 2006
    ..The finished sequence from BAC clones from the genome of the sea urchin, Strongylocentrotus purpuratus, reveals a gene order wherein the anterior genes (Hox1, Hox2 and Hox3) lie nearest the posterior genes ..
  63. ncbi Strongylocentrotus purpuratus transcription factor GATA-E binds to and represses transcription at an Otx-Goosecoid cis-regulatory element within the aboral ectoderm-specific spec2a enhancer
    Takae Kiyama
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Dev Biol 280:436-47. 2005
    During Strongylocentrotus purpuratus embryogenesis, aboral ectoderm-specific expression of spec2a relies on an upstream enhancer that confers its spatial specificity largely through repression...
  64. pmc A new method, using cis-regulatory control, for blocking embryonic gene expression
    Joel Smith
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Dev Biol 318:360-5. 2008
    ..This method thus provides the opportunity to study regulatory requirements of skeletogenesis after ingression, and may be similarly useful in many other developmental contexts...
  65. ncbi Embryonic pattern formation without morphogens
    Hamid Bolouri
    Institute for Systems Biology, Seattle, 1441 N 34th St, Seattle WA 98103, USA
    Bioessays 30:412-7. 2008
    ..Remarkably, this moving ring of gene expression has now been shown to be controlled entirely by transcriptional cis-regulatory logic.1...
  66. ncbi Genes involved in the RNA interference pathway are differentially expressed during sea urchin development
    Jia L Song
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
    Dev Dyn 236:3180-90. 2007
    ..This study elucidated that genes involved in the RNAi silencing pathway have dynamic expression and, thus, may have regulatory roles during germ cell development and embryogenesis...
  67. ncbi Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family
    Jared V Goldstone
    Department of Biology, Woods Hole Oceanographic Institution, Woods Hole
    Mol Biol Evol 24:2619-31. 2007
    ..Subsequently, 10 CYP1-like genes were found in the echinoderm Strongylocentrotus purpuratus (sea urchin) genome...
  68. ncbi SpGataE, a Strongylocentrotus purpuratus ortholog of mammalian Gata4/5/6: protein expression, interaction with putative target gene spec2a, and identification of friend of Gata factor SpFog1
    Takae Kiyama
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Unit 1000, 1515 Holcombe Boulevard, Houston, TX, 77030, USA
    Dev Genes Evol 217:651-63. 2007
    ..In addition to providing new information on Gata and Fog proteins in sea urchins, the anti-SpGataE antibody developed here should be a useful reagent for future analysis of SpGataE function...
  69. pmc Real-time monitoring of functional interactions between upstream and core promoter sequences in living cells of sea urchin embryos
    Akiko Kobayashi
    Division of Molecular and Cellular Biology, International Graduate School of Arts and Sciences, Yokohama City University, Yokohama, Kanagawa, 230 0045, Japan
    Nucleic Acids Res 35:4882-94. 2007
    ..pulcherrimus (Hp) OtxE promoter drives the expression of its own core promoter and that of Strongylocentrotus purpuratus (Sp) Spec2a in different embryonic regions, especially at the late gastrula stage...
  70. pmc Exclusive developmental functions of gatae cis-regulatory modules in the Strongylocentrorus purpuratus embryo
    Pei Yun Lee
    Division of Biology, California Institute of Technology, 1200 E California Blvd, Mail Code 156 29, Pasadena, CA 9112, USA
    Dev Biol 307:434-45. 2007
    The gatae gene of Strongylocentrotus purpuratus is orthologous to vertebrate gata-4,5,6 genes. This gene is expressed in the endomesoderm in the blastula and later the gut of the embryo, and is required for normal development...
  71. pmc Microplate assay for quantifying developmental morphologies: effects of exogenous hyalin on sea urchin gastrulation
    Z Razinia
    Department of Biology, California State University, Northridge, 18111 Nordhoff Street, Northridge, CA 91330 8303, USA
    Zygote 15:159-64. 2007
    ..Using wide-mouthed pipette tips, 25 microl of 24-h Strongylocentrotus purpuratus embryos were transferred to each well of a 96-well polystyrene flat-bottom microplate yielding about ..
  72. ncbi Diversity of olfactomedin proteins in the sea urchin
    Brian J Hillier
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0202, USA
    Genomics 89:721-30. 2007
    ..Only one OLF family member, amassin-1, has been described from the sea urchin Strongylocentrotus purpuratus, a basal invertebrate deuterostome...
  73. ncbi Sequence, annotation and developmental expression of the sea urchin Ca(2+) -ATPase family
    H Jayantha Gunaratne
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0202, USA
    Gene 397:67-75. 2007
    ..The primary structures of Sp-PMCA and Sp-SERCA in the sea urchin, Strongylocentrotus purpuratus (Sp), have been published...
  74. ncbi The oxidative burst at fertilization is dependent upon activation of the dual oxidase Udx1
    Julian L Wong
    Department of Molecular Biology, Cell Biology, and Biochemistry, Box G, Brown University, Providence, RI 02912 USA
    Dev Cell 7:801-14. 2004
    ..Phylogenetic analysis of the enzymatic modules in Udx1 suggests a potentially conserved role for the dual oxidase family in hydrogen peroxide production and regulation during fertilization...
  75. ncbi Hindgut specification and cell-adhesion functions of Sphox11/13b in the endoderm of the sea urchin embryo
    Cesar Arenas-Mena
    Department of Biology, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 4614, USA
    Dev Growth Differ 48:463-72. 2006
    Sphox11/13b is one of the two hox genes of Strongylocentrotus purpuratus expressed in the embryo...
  76. ncbi Regulation of spblimp1/krox1a, an alternatively transcribed isoform expressed in midgut and hindgut of the sea urchin gastrula
    Carolina B Livi
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Gene Expr Patterns 7:1-7. 2007
    ..Conserved sequence patches revealed by a comparison of the blimp1/krox locus in Strongylocentrotus purpuratus and Lytechinus variegatus genomes were tested by gene transfer, in association with GFP or CAT ..
  77. pmc Soluble epoxide hydrolase homologs in Strongylocentrotus purpuratus suggest a gene duplication event and subsequent divergence
    Todd R Harris
    Department of Entomology and Cancer Research Center, University of California, Davis, California 95616, USA
    DNA Cell Biol 27:467-77. 2008
    ..We report the cloning of two 60 kDa multidomain enzymes from the purple sea urchin Strongylocentrotus purpuratus displaying significant sequence similarity to both the N- and C-terminal domains of the mammalian sEH...
  78. pmc Gene regulatory networks for development
    Michael Levine
    Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 102:4936-42. 2005
    ..Here, we survey salient points of these networks, by using as reference those governing specification of the endomesoderm in sea urchin embryos and dorsal-ventral patterning in the Drosophila embryo...
  79. pmc Revisiting the role of H+ in chemotactic signaling of sperm
    Johannes Solzin
    Institut für Biologische Informationsverarbeitung, Forschungszentrum Julich, 52425 Julich, Germany
    J Gen Physiol 124:115-24. 2004
    ..A rise in pHi is also not required for peptide-induced Ca2+ entry into sperm of the sea urchin Strongylocentrotus purpuratus. Speract, a peptide of S...
  80. ncbi Expression patterns of four different regulatory genes that function during sea urchin development
    Takuya Minokawa
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Gene Expr Patterns 4:449-56. 2004
    The spatial and temporal expression patterns of Strongylocentrotus purpuratus genes encoding four different transcription factors, viz...
  81. ncbi Repression of mesodermal fate by foxa, a key endoderm regulator of the sea urchin embryo
    Paola Oliveri
    Division of Biology, 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Development 133:4173-81. 2006
    ..component of the endoderm specification subcircuit of the endomesoderm gene regulatory network in the Strongylocentrotus purpuratus embryo...
  82. ncbi Sphedgehog is expressed by pigment cell precursors during early gastrulation in Strongylocentrotus purpuratus
    Ana L Egana
    Department of Biology, Tufts University, Medford, Massachusetts 02155, USA
    Dev Dyn 231:370-8. 2004
    We have sequenced the Sphedgehog (Sphh) gene from the sea urchin Strongylocentrotus purpuratus. Sphh transcripts are detected first at the mesenchyme blastula stage, and they accumulate throughout early embryogenesis...
  83. ncbi A third sea urchin sperm receptor for egg jelly module protein, suREJ2, concentrates in the plasma membrane over the sperm mitochondrion
    Blanca E Galindo
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0202, USA
    Dev Growth Differ 46:53-60. 2004
    ..In the present study, we describe the sequence, domain structure and localization of suREJ2 and speculate on its possible function...
  84. ncbi Selective expression of a sec1/munc18 member in sea urchin eggs and embryos
    Mariana Leguia
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, 69 Brown Street, Providence, RI 02912, USA
    Gene Expr Patterns 4:645-57. 2004
    ..we have cloned the single SM protein homolog from two species of sea urchin, Lytechinus variegatus and Strongylocentrotus purpuratus. In oocytes and eggs, we find that it localizes to the plasma membrane and the cortical region of the ..
  85. ncbi PLCgamma is enriched on poly-phosphoinositide-rich vesicles to control nuclear envelope assembly
    Richard D Byrne
    Cell Biophysics Laboratory, Cancer Research UK CRUK, London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Cell Signal 19:913-22. 2007
    ....
  86. pmc Sea urchin vault structure, composition, and differential localization during development
    Phoebe L Stewart
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA
    BMC Dev Biol 5:3. 2005
    ..The Pacific coast sea urchin, Strongylocentrotus purpuratus, is an invertebrate model organism that is evolutionarily closer to humans than Drosophila and C...
  87. pmc Two independent forms of endocytosis maintain embryonic cell surface homeostasis during early development
    J Fernando Covian-Nares
    Laboratory of Molecular Physiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Biol 316:135-48. 2008
    ..Inhibition of either form did not trigger compensation by the other form, and phorbol ester treatment rescued the endocytotic activity blocked by agatoxin, but not the retrieval blocked by PAO...
  88. ncbi Biochemical analysis of the interaction of calcium with toposome: a major protein component of the sea urchin egg and embryo
    Michael Hayley
    Department of Biochemistry, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3X9
    J Cell Biochem 103:1464-71. 2008
    ..Collectively, these results further enhance our understanding of the role of Ca(2+) in modulating the biological activity of toposome...
  89. ncbi Genetics. Sea urchin genome confirms kinship to humans and other vertebrates
    Elizabeth Pennisi
    Science 314:908-9. 2006
  90. ncbi Critical tissue copper residues for marine bivalve (Mytilus galloprovincialis) and echinoderm (Strongylocentrotus purpuratus) embryonic development: conceptual, regulatory and environmental implications
    Gunther Rosen
    Space and Naval Warfare Systems Center, Environmental Sciences and Applied Systems Branch, Code 71750, 53475 Strothe Road, San Diego, CA 92152, USA
    Mar Environ Res 66:327-36. 2008
    ..were determined for the Mediterranean mussel (Mytilus galloprovincialis) and purple sea urchin (Strongylocentrotus purpuratus) following laboratory exposure to Cu-spiked seawater collected from San Diego Bay, California, USA...
  91. ncbi Development of sensitive chemical and immunochemical methods for detecting sulfated sialic acids and their application to glycoconjugates from sea urchin sperm and eggs
    Nao Yamakawa
    Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan
    Biochimie 89:1396-408. 2007
    ..Thus, 8-O-sulfation is dependent on the species, gametic cell-type, site-localization of the eggs, and glycoconjugates...
  92. ncbi Dose tolerance at helium and nitrogen temperatures for whole cell electron tomography
    Luis R Comolli
    Life Science Division, Lawrence Berkeley National Laboratory, CA, USA
    J Struct Biol 152:149-56. 2005
    ..We conclude that for cryo-electron tomography of whole cells liquid nitrogen temperature provides better overall data quality...
  93. ncbi A self-organized vortex array of hydrodynamically entrained sperm cells
    Ingmar H Riedel
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Science 309:300-3. 2005
    ..Using a model, we estimated the hydrodynamic interaction force between spermatozoa to be approximately 0.03 piconewtons. Thus, large-scale coordination of cells can be regulated hydrodynamically, and chemical signals are not required...
  94. pmc A putative 'pre-nervous' endocannabinoid system in early echinoderm development
    G A Buznikov
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
    Dev Neurosci 32:1-18. 2010
    Embryos and larvae of sea urchins (Lytechinus variegatus, Strongylocentrotus droebachiensis, Strongylocentrotus purpuratus, Dendraster excentricus), and starfish (Pisaster ochraceus) were investigated for the presence of a functional ..
  95. ncbi Reduction of the fertilizing capacity of sea urchin sperm by cannabinoids derived from marihuana. II. Ultrastructural changes associated with inhibition of the acrosome reaction
    M C Chang
    Department of Anatomical Sciences, School of Medicine and Biomedical Sciences, State University of New York at Buffalo 14214
    Mol Reprod Dev 29:60-71. 1991
    Pretreatment of Strongylocentrotus purpuratus sperm with delta 9-tetrahydrocannabinol (THC) prevents the triggering of the acrosome reaction by egg jelly...
  96. ncbi Reduction of the fertilizing capacity of sea urchin sperm by cannabinoids derived from marihuana. I. Inhibition of the acrosome reaction induced by egg jelly
    H Schuel
    Department of Anatomical Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY 14214
    Mol Reprod Dev 29:51-9. 1991
    ..from marihuana--cannabidiol (CBD) and cannabinol (CBN)--inhibit fertilization in the sea urchin Strongylocentrotus purpuratus by reducing the fertilizing capacity of sperm (Schuel et al., 1987)...
  97. ncbi Molecular characterisation of SALMFamide neuropeptides in sea urchins
    Maurice R Elphick
    School of Biological and Chemical Sciences, Queen Mary, University of London, UK
    J Exp Biol 208:4273-82. 2005
    ..for identification of echinoid SALMFamides was provided by sequencing the genome of the sea urchin Strongylocentrotus purpuratus. Analysis of whole-genome shotgun sequence data using the Basic Local Alignment Search Tool (BLAST) ..
  98. ncbi NG peptides: a novel family of neurophysin-associated neuropeptides
    Maurice R Elphick
    Queen Mary University of London, School of Biological and Chemical Sciences, Mile End Road, London, E1 4NS, UK
    Gene 458:20-6. 2010
    ..This textbook perspective on neurophysins changed with the discovery of a gene in the sea urchin Strongylocentrotus purpuratus (phylum Echinodermata) encoding a precursor protein comprising a neurophysin domain in association ..
  99. pmc Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes
    Tsukasa Kawahara
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    BMC Evol Biol 7:109. 2007
    ....
  100. ncbi Complexity and organization of DNA-protein interactions in the 5'-regulatory region of an endoderm-specific marker gene in the sea urchin embryo
    C H Yuh
    Division of Biology 156 29, California Institute of Technology, Pasadena 91125
    Mech Dev 47:165-86. 1994
    ..of sites of specific DNA/protein interaction within the regulatory domain of the Endo16 gene of Strongylocentrotus purpuratus. Earlier work had displayed a complex pattern of expression of this gene during embryogenesis...
  101. ncbi Structure and tissue-specific developmental expression of a sea urchin arylsulfatase gene
    Q Yang
    Department of Biology, University of Rochester, New York 14627
    Dev Biol 135:53-65. 1989
    ..an arylsulfatase (SpARS) message that encodes an abundant protein of pluteus larvae of the sea urchin Strongylocentrotus purpuratus. Although vertebrate arylsulfatases have broad tissue distributions, in situ hybridization with a ..

Research Grants29

  1. Characterization of Aging in Sea Urchin Species with Different Life Spans
    Andrea Bodnar; Fiscal Year: 2012
    ..urchins species with different life spans;Strongylocentrotus franciscanus (life span >100 years), Strongylocentrotus purpuratus (life span 50 years) and Lytechinus variegatus (life span 4 years)...
  2. TLR Ectodomains for Microbial Detection and Therapeutics
    Neal Silverman; Fiscal Year: 2013
    ..In addition to mammalian TLRs/NLRs, the purple sea urchin (Strongylocentrotus purpuratus) has a greatly expanded repertoire of pattern recognition receptors, in lieu of an adaptive immune ..
  3. Notch pathway maintenance of the immortal germ line
    STEVEN ZACHARY SWARTZ; Fiscal Year: 2013
    ..SpMibL, enriched in the presumptive germ cells called small micromeres (SMMs) of the sea urchin Strongylocentrotus purpuratus. These cells are allocated early in early development and are used to construct adult tissues during ..
  4. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric H Davidson; Fiscal Year: 2013
    ..This revised proposal seeks support for the Gene Library Resource for the purple sea urchin, Strongylocentrotus purpuratus. This Resource provides the essential infrastructure, new technology, molecular biology support ..
  5. SpBase: A Database System For Echinoderm Genome Information
    ROBERT ANDREW CAMERON; Fiscal Year: 2013
    ..is to gather, collate and present genomic information for echinoderm species including the reference, Strongylocentrotus purpuratus (Sp) through an easily managed web information system (http://spbase.org)...
  6. Control of Cell Proliferation by Runx Proteins
    JAMES COFFMAN; Fiscal Year: 2009
    ..Unlike mammals, which have 3 Runx genes, the sea urchin Strongylocentrotus purpuratus has only a single Runx gene (SpRunt)...
  7. Redox-sensitive developmental pathways and gene regulatory networks
    JAMES COFFMAN; Fiscal Year: 2009
    ..Finally, the Comparative Toxicogenomics Database (CTD) at MDIBL will be used to determine the relevance of the pathways discovered in sea urchins to human health, and to generate hypotheses that might explain specific human diseases. ..
  8. Mechanism of cytochrome P450 uncoupling and inactivation
    JARED GOLDSTONE; Fiscal Year: 2005
    ..Recently identified AhR-agonistic persistent pollutants, such as polybrominated diphenyl ethers will also be investigated. ..
  9. CONFOCAL MICROSCOPE
    Gary Wessel; Fiscal Year: 2003
    ..The requested instrument would significantly enhance the research productivity of the broad, interdisciplinary community of researchers described here, and greatly improve the biological image capabilities in the region. ..
  10. Regulatory Genomics: BAC-GFP Library of Control Genes
    Eric Davidson; Fiscal Year: 2008
    ..vectors of all transcription factors expressed significantlyin the embryo of the sea urchin, Strongylocentrotus purpuratus, the genomic sequence of which will go on line shortly...
  11. Spiralian developmental system for the study of multipotency
    Cesar Arenas Mena; Fiscal Year: 2008
    ..The ultimate goal is to manipulate these genes and reprogram in vivo differentiated cells into multipotent stem cells. [unreadable] [unreadable] [unreadable]..
  12. Structure of Circadian Clock Complexes from Cyanobacteria by Three Dimensional EM
    Phoebe L Stewart; Fiscal Year: 2010
    ..abstract_text> ..
  13. CRYO-EM STRUCTURAL STUDIES OF ADENOVIRUS CELL ENTRY
    Phoebe L Stewart; Fiscal Year: 2010
    ..Understanding the molecular principles of this natural defense mechanism could lead to novel strategies for antiviral drug design. ..
  14. Misregulation of apoptosis in cloned pig embryos
    Heide Schatten; Fiscal Year: 2007
    ..Pilot data from this R03 small grants program research will be used to apply for funding through the R01 mechanism. [unreadable] [unreadable] [unreadable]..
  15. INTERACTIONS BETWEEN F-ACTIN, MYOSIN II AND MICROTUBULES
    Garrett Odell; Fiscal Year: 2001
    ..elegans blastomeres. ..
  16. Acquisition of a Liquid Helium Cryo-Electron Microscope
    PHOEBE STEWART; Fiscal Year: 2003
    ..The financial plan for the long term operation of the microscope includes a significant additional commitment from UCLA for microscope operating expenses. ..
  17. Cytoplasmic Reactivation of p53 Family Members
    Charles Walker; Fiscal Year: 2004
    ..Overexpression might overwhelm mechanisms that sequester these proteins in the cytoplasm of leukemic clam hemocytes and lead to a resumption of clam p53 and/or p63/73-induced apoptosis. ..
  18. NEUROTROPHIN RECEPTOR INTERACTIONS
    Mark Bothwell; Fiscal Year: 2004
    ..The patterns of developmental expression of P75/NTR, NRH1 and NRH2 will be examined in Xenopus and mice, to assess whether the opportunity for functional interactions exist. ..
  19. Mitochondria distribution in cloned pig embryos
    Heide Schatten; Fiscal Year: 2005
    ..Pilot data from this RO3 small grants program research will be used to apply for funding through the RO1 mechanism. ..
  20. Cytoskeletal organization in apicomplexan parasites
    Heide Schatten; Fiscal Year: 2005
    ..Pilot data from this RO3 research will be used to apply for funding through the RO1 mechanism. ..
  21. Amyloid Precursor Protein Signaling
    Mark Bothwell; Fiscal Year: 2006
    ..Effects of agonistic APP monoclonal antibody, beta-amyloid peptide, LRP, and alpha-2 macroglobulin on APP signaling will be assessed. ..
  22. Initiation of Multidrug Transport at Fertilization.
    Amro Hamdoun; Fiscal Year: 2007
    ..abstract_text> ..
  23. Nogo Receptor Signaling and Function
    Mark Bothwell; Fiscal Year: 2007
    ..Effects of these manipulations on axonal targeting will be assessed by injecting the fluorescent marker Dil into embryos to allow microscopic imaging of axon trajectories. ..
  24. Olympus FV1000 Laser Scanning Confocal Microscope
    William Bement; Fiscal Year: 2007
    ..This information, in turn, will help guide future investigations of a number of normal and pathological human processes such as wound repair, nerve regeneration, cancer, and birth defects. [unreadable] [unreadable] [unreadable]..
  25. Intelligent Information Systems for Systems Biology
    Leroy Hood; Fiscal Year: 2003
    ..Finally, we propose some novel educational programs designed to put graduate students together into interdisciplinary teams for problem solving. ..
  26. Transcriptional Regulation of Oocyte-Specific Genes
    Jia Song; Fiscal Year: 2007
    ..Defining transcription complexes that regulate several oocyte gene promoters will create a paradigm in gene regulatory networks that orchestrates the development of oocytes and further our knowledge in reproductive biology. ..