bombyx

Summary

Summary: A genus of silkworm MOTHS in the family Bombycidae of the order LEPIDOPTERA. The family contains a single species, Bombyx mori from the Greek for silkworm + mulberry tree (on which it feeds). A native of Asia, it is sometimes reared in this country. It has long been raised for its SILK and after centuries of domestication it probably does not exist in nature. It is used extensively in experimental GENETICS. (From Borror et al., An Introduction to the Study of Insects, 4th ed, p519)

Top Publications

  1. pmc MicroRNAs of Bombyx mori identified by Solexa sequencing
    Shiping Liu
    The Key Sericultural Laboratory of Agricultural Ministry, College of Biotechnology, Southwest University, Tiansheng Road, Beibei, Chongqing 400715, PR China
    BMC Genomics 11:148. 2010
  2. pmc SilkDB v2.0: a platform for silkworm (Bombyx mori ) genome biology
    Jun Duan
    The Key Sericultural Laboratory of Agricultural Ministry, Southwest University, Chongqing 400716, China
    Nucleic Acids Res 38:D453-6. 2010
  3. ncbi Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in the silkworm, Bombyx mori
    Xiaodong Xie
    The Institute of Agricultural and Life Science, Chongqing University, Chongqing 400044, China
    Mol Biol Rep 39:7281-91. 2012
  4. ncbi Insect olfactory receptors are heteromeric ligand-gated ion channels
    Koji Sato
    Department of Integrated Biosciences, The University of Tokyo, Chiba 277 8562, Japan
    Nature 452:1002-6. 2008
  5. ncbi Insect sex-pheromone signals mediated by specific combinations of olfactory receptors
    Takao Nakagawa
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277 8562, Japan
    Science 307:1638-42. 2005
  6. pmc Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx)
    Qingyou Xia
    Key Sericultural Laboratory of Agricultural Ministry, College of Biotechnology, Southwest University, Chongqing 400715, China
    Science 326:433-6. 2009
  7. pmc Genome-wide identification and characterization of ATP-binding cassette transporters in the silkworm, Bombyx mori
    Shumin Liu
    Key Laboratory of Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    BMC Genomics 12:491. 2011
  8. pmc Single amino acid mutation in an ATP-binding cassette transporter gene causes resistance to Bt toxin Cry1Ab in the silkworm, Bombyx mori
    Shogo Atsumi
    Division of Insect Sciences, National Institute of Agrobiological Sciences, Tsukuba 305 8634, Japan
    Proc Natl Acad Sci U S A 109:E1591-8. 2012
  9. pmc Identification and functional characterization of a sex pheromone receptor in the silkmoth Bombyx mori
    Takeshi Sakurai
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Kyoto 606 8502, Japan
    Proc Natl Acad Sci U S A 101:16653-8. 2004
  10. pmc A single sex pheromone receptor determines chemical response specificity of sexual behavior in the silkmoth Bombyx mori
    Takeshi Sakurai
    Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan
    PLoS Genet 7:e1002115. 2011

Detail Information

Publications377 found, 100 shown here

  1. pmc MicroRNAs of Bombyx mori identified by Solexa sequencing
    Shiping Liu
    The Key Sericultural Laboratory of Agricultural Ministry, College of Biotechnology, Southwest University, Tiansheng Road, Beibei, Chongqing 400715, PR China
    BMC Genomics 11:148. 2010
    ..three small RNA libraries prepared from the whole body, and the anterior-middle and posterior silk glands of Bombyx mori, with a view to expanding the repertoire of silkworm miRNAs and exploring transcriptional differences in ..
  2. pmc SilkDB v2.0: a platform for silkworm (Bombyx mori ) genome biology
    Jun Duan
    The Key Sericultural Laboratory of Agricultural Ministry, Southwest University, Chongqing 400716, China
    Nucleic Acids Res 38:D453-6. 2010
    The SilkDB is an open-access database for genome biology of the silkworm (Bombyx mori)...
  3. ncbi Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in the silkworm, Bombyx mori
    Xiaodong Xie
    The Institute of Agricultural and Life Science, Chongqing University, Chongqing 400044, China
    Mol Biol Rep 39:7281-91. 2012
    ..These results might provide new insights for further functional studies on the ABC genes in the silkworm genome...
  4. ncbi Insect olfactory receptors are heteromeric ligand-gated ion channels
    Koji Sato
    Department of Integrated Biosciences, The University of Tokyo, Chiba 277 8562, Japan
    Nature 452:1002-6. 2008
    ..The ligand-gated ion channel formed by an insect OR complex seems to be the basis for a unique strategy that insects have acquired to respond to the olfactory environment...
  5. ncbi Insect sex-pheromone signals mediated by specific combinations of olfactory receptors
    Takao Nakagawa
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277 8562, Japan
    Science 307:1638-42. 2005
    We describe two male-specific olfactory receptors (ORs) in the silk moth, Bombyx mori, that are mutually exclusively expressed in a pair of adjacent pheromone-sensitive neurons of male antennae: One is specifically tuned to bombykol, the ..
  6. pmc Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx)
    Qingyou Xia
    Key Sericultural Laboratory of Agricultural Ministry, College of Biotechnology, Southwest University, Chongqing 400715, China
    Science 326:433-6. 2009
    ..These data add to our understanding of the domestication processes and may have applications in devising pest control strategies and advancing the use of silkworms as efficient bioreactors...
  7. pmc Genome-wide identification and characterization of ATP-binding cassette transporters in the silkworm, Bombyx mori
    Shumin Liu
    Key Laboratory of Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    BMC Genomics 12:491. 2011
    ..In insects, ABC transporters not only have important functions in molecule transport, but also play roles in insecticide resistance, metabolism and development...
  8. pmc Single amino acid mutation in an ATP-binding cassette transporter gene causes resistance to Bt toxin Cry1Ab in the silkworm, Bombyx mori
    Shogo Atsumi
    Division of Insect Sciences, National Institute of Agrobiological Sciences, Tsukuba 305 8634, Japan
    Proc Natl Acad Sci U S A 109:E1591-8. 2012
    ..By using Bombyx mori as a model, we identified a candidate gene for a recessive form of resistance to Cry1Ab toxin on chromosome ..
  9. pmc Identification and functional characterization of a sex pheromone receptor in the silkmoth Bombyx mori
    Takeshi Sakurai
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Kyoto 606 8502, Japan
    Proc Natl Acad Sci U S A 101:16653-8. 2004
    ..Bombykol in the silkmoth Bombyx mori was the first sex pheromone to be identified...
  10. pmc A single sex pheromone receptor determines chemical response specificity of sexual behavior in the silkmoth Bombyx mori
    Takeshi Sakurai
    Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan
    PLoS Genet 7:e1002115. 2011
    ..The silkmoth, Bombyx mori, utilizes the simplest possible pheromone system, in which a single pheromone component, (E, Z)-10,12-..
  11. pmc Materials fabrication from Bombyx mori silk fibroin
    Danielle N Rockwood
    Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, USA
    Nat Protoc 6:1612-31. 2011
    Silk fibroin, derived from Bombyx mori cocoons, is a widely used and studied protein polymer for biomaterial applications...
  12. ncbi A draft sequence for the genome of the domesticated silkworm (Bombyx mori)
    Qingyou Xia
    Southwest Agricultural University, Chongqing Beibei, 400716, China
    Science 306:1937-40. 2004
    We report a draft sequence for the genome of the domesticated silkworm (Bombyx mori), covering 90.9% of all known silkworm genes. Our estimated gene count is 18,510, which exceeds the 13,379 genes reported for Drosophila melanogaster...
  13. ncbi A genome-wide analysis of genes and gene families involved in innate immunity of Bombyx mori
    Hiromitsu Tanaka
    Innate Immunity Research Unit, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    Insect Biochem Mol Biol 38:1087-110. 2008
    A genome-wide analysis of innate immunity-related genes and gene families was conducted using the silkworm, Bombyx mori...
  14. ncbi Female-biased expression of odourant receptor genes in the adult antennae of the silkworm, Bombyx mori
    K W Wanner
    Department of Entomology, University of Illinois, Urbana 61801, USA
    Insect Mol Biol 16:107-19. 2007
    ..We have identified 41 Or gene sequences from the silkworm (Bombyx mori) genome, more than double the number of published Or sequences from the Lepidoptera...
  15. pmc New opportunities for an ancient material
    Fiorenzo G Omenetto
    Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA
    Science 329:528-31. 2010
    ..These bio-inspired and high-technology materials can lead to multifunctional material platforms that integrate with living systems for medical materials and a host of other applications...
  16. ncbi CYP306A1, a cytochrome P450 enzyme, is essential for ecdysteroid biosynthesis in the prothoracic glands of Bombyx and Drosophila
    Ryusuke Niwa
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 5 1 5 Kashiwanoha, Kashiwa, Chiba 277 8562, USA
    J Biol Chem 279:35942-9. 2004
    ..P450 gene, designated Cyp306a1, that is essential for ecdysteroid biosynthesis in the PGs of the silkworm Bombyx mori and fruit fly Drosophila melanogaster...
  17. pmc Insect-Specific microRNA Involved in the Development of the Silkworm Bombyx mori
    Yong Zhang
    Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, People s Republic of China
    PLoS ONE 4:e4677. 2009
    ..We conducted a large-scale screening for miRNA genes in the silkworm Bombyx mori using sequence-by-synthesis (SBS) deep sequencing of mixed RNAs from egg, larval, pupal, and adult stages...
  18. pmc The odorant binding protein gene family from the genome of silkworm, Bombyx mori
    Da Ping Gong
    The Key Sericultural Laboratory of Agricultural Ministry, Southwest University, Chongqing, PR China
    BMC Genomics 10:332. 2009
    ..Insect chemoreception is mediated by two large and diverse gene superfamilies, chemoreceptors and odorant binding proteins (OBPs). OBPs are believed to transport hydrophobic odorants from the environment to the olfactory receptors...
  19. ncbi The unique evolution of neuropeptide genes in the silkworm Bombyx mori
    Ladislav Roller
    Institute of Zoology, Slovak Academy of Sciences, Bratislava, Slovakia
    Insect Biochem Mol Biol 38:1147-57. 2008
    Cloning-based approach combining homology search in the Bombyx genome sequence and Rapid Amplification of cDNA Ends (RACE) resulted in annotation of 23 neuropeptide genes and different splicing variants of three genes...
  20. pmc A comparative analysis of serpin genes in the silkworm genome
    Zhen Zou
    Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA
    Genomics 93:367-75. 2009
    ..There are thirty-four serpin genes in Bombyx mori. Six are highly similar to their Manduca sexta orthologs that regulate innate immunity...
  21. pmc Transcriptome analysis of the silkworm (Bombyx mori) by high-throughput RNA sequencing
    Yinü Li
    Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China
    PLoS ONE 7:e43713. 2012
    The domestic silkworm, Bombyx mori, is a model insect with important economic value for silk production that also acts as a bioreactor for biomaterial production...
  22. ncbi Phantom encodes the 25-hydroxylase of Drosophila melanogaster and Bombyx mori: a P450 enzyme critical in ecdysone biosynthesis
    James T Warren
    Department of Biology, University of North Carolina, 342 Wilson Hall, CB 3280, Chapel Hill, NC 27599 3280, USA
    Insect Biochem Mol Biol 34:991-1010. 2004
    ..gene identification has also resulted in the characterization of the corresponding 25-hydroxylase gene in Bombyx mori...
  23. ncbi cDNA cloning of acyl-CoA desaturase homologs in the silkworm, Bombyx mori
    T Yoshiga
    Laboratory of Molecular Entomology and Baculovirology, RIKEN, Hirosawa 2 1, Wako, Saitama, Japan
    Gene 246:339-45. 2000
    ..desaturase clones from a pheromone gland cDNA library by using the EST (expressed sequence tag) database of Bombyx mori...
  24. ncbi Discovering microRNAs from Bombyx mori nucleopolyhedrosis virus
    J Singh
    Centre of Excellence for Genetics and Genomics of Silkmoths, Laboratory of Molecular Genetics, Centre for DNA Fingerprinting and Diagnostics, Tuljaguda Complex, Mozamjahi Road, Nampally, Hyderabad 500001, India
    Virology 407:120-8. 2010
    ..In the study reported here, we have identified four Bombyx mori nucleopolyhedrosis virus (BmNPV)-encoded miRNAs using a combination of in silico and experimental methods...
  25. ncbi Silk-based biomaterials
    Gregory H Altman
    Department of Chemical and Biological Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Biomaterials 24:401-16. 2003
    Silk from the silkworm, Bombyx mori, has been used as biomedical suture material for centuries. The unique mechanical properties of these fibers provided important clinical repair options for many applications...
  26. ncbi A pheromone-binding protein mediates the bombykol-induced activation of a pheromone receptor in vitro
    Ewald Grosse-Wilde
    Institute of Physiology 230, University of Hohenheim, Garbenstrasse 30, 70599 Stuttgart, Germany
    Chem Senses 31:547-55. 2006
    The enormous capacity of the male silkmoth Bombyx mori in recognizing and discriminating bombykol and bombykal is based on distinct sensory neurons in the antennal sensilla hairs...
  27. pmc Sugar-regulated cation channel formed by an insect gustatory receptor
    Koji Sato
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113 8657, Japan
    Proc Natl Acad Sci U S A 108:11680-5. 2011
    ..We reconstituted sugar responses of Bombyx mori Gr-9 (BmGr-9), a silkworm Gr, in two heterologous expression systems...
  28. ncbi Disulfide structure of the pheromone binding protein from the silkworm moth, Bombyx mori
    W S Leal
    Laboratory of Chemical Prospecting, National Institute of Sericultural and Entomological Science, 1 2 Ohwashi, Tsukuba, Japan
    FEBS Lett 464:85-90. 1999
    ..followed by digestion with endoproteinase Lys-C to determine the disulfide connectivity in the PBP from Bombyx mori (BmPBP)...
  29. ncbi Genome-wide screening and characterization of transposable elements and their distribution analysis in the silkworm, Bombyx mori
    Mizuko Osanai-Futahashi
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba, Japan
    Insect Biochem Mol Biol 38:1046-57. 2008
    ..This analysis suggests that Bombyx genome is influenced by numerous amounts and variety of TEs.
  30. ncbi Efficient disruption of endogenous Bombyx gene by TAL effector nucleases
    Suresh Sajwan
    Institute of Entomology, Biology Centre ASCR, and Faculty of Science, University of South Bohemia, 37005 Ceske Budejovice, Czech Republic
    Insect Biochem Mol Biol 43:17-23. 2013
    ..We showed earlier that zinc finger nucleases (ZFNs) can be used for generating gene-specific mutations in Bombyx mori by an error-prone DNA repair process of non-homologous end joining (NHEJ)...
  31. ncbi Isolation and characterization of a Bombyx vasa-like gene
    H Nakao
    Department of Insect Genetics and Breeding, National Institute of Sericultural and Entomological Science, 1 2 Oowashi, Tsukuba 305 8634, Japan
    Dev Genes Evol 209:312-6. 1999
    AcDNA for a vasa-like gene (BmVLG) was isolated from Bombyx mori. As with vasa in Drosophila, the expression is restricted to the germline in the larval (and pupal and adult?) stage, and the maternal transcript exists...
  32. ncbi Characterization of a novel silkworm (Bombyx mori) phenol UDP-glucosyltransferase
    Teresa Luque
    Department of Biology, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK
    Eur J Biochem 269:819-25. 2002
    ..the molecular cloning and functional characterization of a phenol UDP-glucosyltransferase (UGT) from the silkworm, Bombyx mori, which was named BmUGT1. The complete cDNA clone is 1...
  33. ncbi SID-1 protein of Caenorhabditis elegans mediates uptake of dsRNA into Bombyx cells
    Isao Kobayashi
    Transgenic Silkworm Research Unit, National Institute of Agrobiological Sciences, 1 2 Ohwashi, Tsukuba, Ibaraki 305 8634, Japan
    Insect Biochem Mol Biol 42:148-54. 2012
    ..However, in Bombyx mori, as with many lepidopteran species, attempts at systemic RNAi have had mixed success...
  34. ncbi Proteomic analysis of peritrophic membrane (PM) from the midgut of fifth-instar larvae, Bombyx mori
    Xiaolong Hu
    College of Animal Science, Zhejiang University, Hangzhou, 310029, China
    Mol Biol Rep 39:3427-34. 2012
    ....
  35. pmc Hindgut innate immunity and regulation of fecal microbiota through melanization in insects
    Qimiao Shao
    Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, People s Republic of China
    J Biol Chem 287:14270-9. 2012
    ..We used the silkworm Bombyx mori as a model and found that prophenoloxidase produced by hindgut cells is secreted into the hindgut contents...
  36. ncbi Comparative analysis of Bombyx mori nucleopolyhedrovirus responsive genes in fat body and haemocyte of B. mori resistant and susceptible strains
    Y Y Bao
    Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou, China
    Insect Mol Biol 19:347-58. 2010
    The infection profiles of the Bombyx mori nucleopolyhedrovirus (BmNPV) in B...
  37. ncbi Mutation of a novel ABC transporter gene is responsible for the failure to incorporate uric acid in the epidermis of ok mutants of the silkworm, Bombyx mori
    Lingyan Wang
    Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Insect Biochem Mol Biol 43:562-71. 2013
    ok mutants of the silkworm, Bombyx mori, exhibit highly translucent larval skin resulting from the inability to incorporate uric acid into the epidermal cells...
  38. pmc Genome-wide identification of polycomb target genes reveals a functional association of Pho with Scm in Bombyx mori
    Zhiqing Li
    Laboratory of Silkworm Science, Kyushu University Graduate School of Bioresource and Bioenvironmental Sciences, Fukuoka, Japan
    PLoS ONE 7:e34330. 2012
    ..Here, we identified Polycomb target genes in Bombyx mori with holocentric centromere using genome-wide expression screening based on the knockdown of BmSCE, BmESC, ..
  39. ncbi Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata
    Terunori Kinjoh
    Faculty of Agriculture and Life Sciences, Hirosaki University, Hirosaki 036 8561, Japan
    Insect Biochem Mol Biol 37:808-18. 2007
    ..of all enzymes involved in the mevalonate pathway portion of the juvenile hormone (JH) biosynthetic pathway in Bombyx mori, i.e., those responsible for the formation of farnesyl diphosphate from acetyl-CoA...
  40. ncbi The ATP-binding cassette transporter subfamily C member 2 in Bombyx mori larvae is a functional receptor for Cry toxins from Bacillus thuringiensis
    Shiho Tanaka
    Graduate School of Bio Applications and Systems Engineering, Tokyo University of Agriculture and Technology, Japan
    FEBS J 280:1782-94. 2013
    ..To address this important knowledge gap, we investigated the role of Bombyx mori ABCC2 (BmABCC2) or its mutant from a Cry1Ab-resistant B. mori strain on Cry1A toxin action...
  41. ncbi Genome-wide analysis of cytochrome P450 monooxygenase genes in the silkworm, Bombyx mori
    Junwen Ai
    The Sericultural Research Institute of Hunan, Changsha, China
    Gene 480:42-50. 2011
    ..The distribution of Bombyx mori P450s in the genome shows that most of them are tandem arranged on chromosomes, only 34 genes are present as ..
  42. ncbi The complete mitogenome and phylogenetic analysis of Bombyx mandarina strain Qingzhou
    Xiao long Hu
    Medical College of Soochow University, 215123 Suzhou, China
    Mol Biol Rep 37:2599-608. 2010
    The complete nucleotide sequence of the mitogenome of Bombyx mandarina strain Qingzhou was determined. The circular genome is 15,717 bp long and has the typical gene organization and order of lepidopteran mitogenomes...
  43. ncbi BmSE, a SINE family with 3' ends of (ATTT) repeats in domesticated silkworm (Bombyx mori)
    Jinshan Xu
    Laboratory of Animal Biology, Chongqing Normal University, Chongqing 400047, China
    J Genet Genomics 37:125-35. 2010
    ..A 294 bp novel SINE family, designated as BmSE, was identified by mining the database of the complete Bombyx mori genome...
  44. pmc Genome-wide identification and expression analysis of serine proteases and homologs in the silkworm Bombyx mori
    Ping Zhao
    The Key Sericultural Laboratory of Agricultural Ministry, Southwest University, Chongqing 400715, PR China
    BMC Genomics 11:405. 2010
    ..Genome-wide identification and expression analysis of serine proteases and their homologs in the silkworm might provide valuable information about their biological functions...
  45. pmc The genomic underpinnings of apoptosis in the silkworm, Bombyx mori
    Jin Ye Zhang
    The Key Sericultural Laboratory of Agricultural Ministry, Institute of Sericulture and Systems Biology, Southwest University, Chongqing 400715, China
    BMC Genomics 11:611. 2010
    ..Herein we have identified apoptosis-related genes in the silkworm Bombyx mori and compared them to those from insects, mammals, and nematodes.
  46. ncbi Novel microRNAs in silkworm (Bombyx mori)
    Yimei Cai
    Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China
    Funct Integr Genomics 10:405-15. 2010
    ..Target prediction uncovers that considerable silkworm miRNAs may aim at modulating more than one hormone signaling pathway components and/or hormone biosynthesis-related proteins implying their important roles in silkworm development...
  47. pmc Hormone signaling linked to silkmoth sex pheromone biosynthesis involves Ca2+/calmodulin-dependent protein kinase II-mediated phosphorylation of the insect PAT family protein Bombyx mori lipid storage droplet protein-1 (BmLsd1)
    Atsushi Ohnishi
    RIKEN Advanced Science Institute, 2 1 Hirosawa, Wako, Saitama, 351 0198, Japan
    J Biol Chem 286:24101-12. 2011
    ..In the silkmoth, Bombyx mori, cytoplasmic lipid droplets, which store the sex pheromone (bombykol) precursor fatty acid, accumulate in PG ..
  48. ncbi Sex determination in the silkworm, Bombyx mori: a female determinant on the W chromosome and the sex-determining gene cascade
    Tsuguru Fujii
    Laboratory of Insect Genetics and Bioscience, Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Semin Cell Dev Biol 18:379-88. 2007
    ..The sex of the silkworm, Bombyx mori, is strongly controlled by the presence of the W chromosome...
  49. ncbi Characterization of acyl-CoA-binding protein (ACBP) in the pheromone gland of the silkworm, Bombyx mori
    S Matsumoto
    The Institute of Physical and Chemical Research RIKEN, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Insect Biochem Mol Biol 31:603-9. 2001
    ..We have purified a 10-kDa protein from the cytosolic fraction of Bombyx mori pheromone glands by using affinity chromatography with a palmitoyl-CoA-agarose column and reversed-phase HPLC...
  50. ncbi Amino acid sequence of pheromone-biosynthesis-activating neuropeptide (PBAN) of the silkworm, Bombyx mori
    A Kitamura
    Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo, Japan
    Biochem Biophys Res Commun 163:520-6. 1989
    ..PBAN), named PBAN-I and -II, as fully oxidized forms of Met residues from adult heads of the silkworm, Bombyx mori. PBAN-I was identical with the PBAN which we had isolated before...
  51. pmc Pheromone gland-specific fatty-acyl reductase of the silkmoth, Bombyx mori
    Ken ichi Moto
    RIKEN, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 100:9156-61. 2003
    ..In experiments designed to characterize a pheromone-gland-specific FAR in the silkmoth, Bombyx mori, we have isolated a cDNA clone encoding a protein homologous to a FAR from the desert shrub, Simmondsia ..
  52. ncbi Identification, genomic organization and expression pattern of glutathione S-transferase in the silkworm, Bombyx mori
    Quanyou Yu
    The Key Sericultural Laboratory of Agricultural Ministry, College of Biotechnology, Southwest University, Chongqing, China
    Insect Biochem Mol Biol 38:1158-64. 2008
    ..We have identified 23 putative cytosolic GSTs by searching the new assembly of the Bombyx mori genome sequence. Phylogenetic analyses on the amino acid sequences reveal that 21 of the B...
  53. ncbi Identification and expression pattern of the chemosensory protein gene family in the silkworm, Bombyx mori
    Da Ping Gong
    The Key Sericultural Laboratory of Agricultural Ministry, Southwest University, Chongqing 400716, China
    Insect Biochem Mol Biol 37:266-77. 2007
    ..The majority of silkworm CSP genes are expressed broadly in tissues including the antennae, head, thorax, legs, wings, epithelium, testes, ovaries, pheromone glands, wing disks, and compound eyes...
  54. pmc A genome-wide survey for host response of silkworm, Bombyx mori during pathogen Bacillus bombyseptieus infection
    Lulin Huang
    Institute of Sericulture and Systems Biology, Southwest University, Chongqing, China
    PLoS ONE 4:e8098. 2009
    ..can produces spores and parasporal crystals was firstly separated from the corpses of the infected silkworms (Bombyx mori)...
  55. ncbi Non-molting glossy/shroud encodes a short-chain dehydrogenase/reductase that functions in the 'Black Box' of the ecdysteroid biosynthesis pathway
    Ryusuke Niwa
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tennoudai 1 1 1, Tsukuba, Ibaraki 305 8572, Japan
    Development 137:1991-9. 2010
    ..This gene was first isolated by positional cloning of the nm-g mutant of the silkworm Bombyx mori, which exhibits a low ecdysteroid titer and consequently causes a larval arrest phenotype...
  56. ncbi Odorant-binding proteins and chemosensory proteins in pheromone detection and release in the silkmoth Bombyx mori
    Francesca R Dani
    Centro Interdipartimentale di Spettrometria di Massa, University of Firenze, Viale G Pieraccini no 6, Florence, Italy
    Chem Senses 36:335-44. 2011
    The genome of the silkmoth Bombyx mori contains 44 genes encoding odorant-binding proteins (OBPs) and 20 encoding chemosensory proteins (CSPs)...
  57. pmc ERK- and JNK-dependent signaling pathways contribute to Bombyx mori nucleopolyhedrovirus infection
    Susumu Katsuma
    Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    J Virol 81:13700-9. 2007
    ..explore intracellular signaling pathways induced by baculovirus infection, we examined the involvement of MAPKs in Bombyx mori nucleopolyhedrovirus (BmNPV) infection of BmN cells...
  58. pmc MicroRNAs show diverse and dynamic expression patterns in multiple tissues of Bombyx mori
    Shiping Liu
    The Key Sericultural Laboratory of Agricultural Ministry, College of Biotechnology, Southwest University, Chongqing 400715, PR China
    BMC Genomics 11:85. 2010
    ..Tissue-specific expression of miRNAs is highly relevant to their physiological roles in the corresponding tissues. However, to date, few miRNAs have been spatially identified in the silkworm...
  59. pmc The silkworm Z chromosome is enriched in testis-specific genes
    K P Arunkumar
    Centre of Excellence for Genetics and Genomics of Silkmoths, Laboratory of Molecular Genetics, Centre for DNA Fingerprintingand Diagnostics, Tuljaguda, Nampally, Hyderabad, India
    Genetics 182:493-501. 2009
    ..We examined the testis transcriptome of the silkworm, Bombyx mori, which has a ZW chromosome constitution in the female and ZZ in the male, and show that the Z chromosome ..
  60. ncbi Functional characterization of the Bombyx mori fatty acid transport protein (BmFATP) within the silkmoth pheromone gland
    Atsushi Ohnishi
    Molecular Entomology Laboratory, Advanced Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    J Biol Chem 284:5128-36. 2009
    ..By exploiting this unique system in the PG of the silkmoth, Bombyx mori, we found that BmFATP is predominantly expressed in the PG and undergoes up-regulation 1 day prior to ..
  61. ncbi Sex chromosomes and sex determination in Lepidoptera
    W Traut
    Universitat Lubeck, Zentrum fur Medizinische Strukturbiologie, Institut fur Biologie, Lubeck, Germany
    Sex Dev 1:332-46. 2007
    ..Special strains have been devised for mass rearing of male-only broods in the silkworm for higher silk production and in pest species for the release of sterile males in pest management programs...
  62. pmc Horizontal gene transfer in silkworm, Bombyx mori
    Bo Zhu
    State Key Laboratory of Rice Biology and Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Ministry of Agriculture, Institute of Biotechnology, Zhejiang University, Hangzhou 310029, China
    BMC Genomics 12:248. 2011
    The domesticated silkworm, Bombyx mori, is the model insect for the order Lepidoptera, has economically important values, and has gained some representative behavioral characteristics compared to its wild ancestor. The genome of B...
  63. ncbi Targeted mutagenesis in the silkworm Bombyx mori using zinc finger nuclease mRNA injection
    Yoko Takasu
    Biology Centre, Academy of Sciences and the Faculty of Natural Sciences, University of South Bohemia, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
    Insect Biochem Mol Biol 40:759-65. 2010
    ..To evaluate the applicability of this method to gene targeting in another insect, we mutagenized the Bombyx mori epidermal color marker gene BmBLOS2, which controls the formation of uric acid granules in the larval ..
  64. ncbi Cloning and characterization of the pheromone biosynthesis activating neuropeptide receptor from the silkmoth, Bombyx mori. Significance of the carboxyl terminus in receptor internalization
    J Joe Hull
    Molecular Entomology Laboratory, RIKEN The Institute of Physical and Chemical Research, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    J Biol Chem 279:51500-7. 2004
    ..homologues, a full-length 2780-nucleotide clone encoding a 46-kDa G protein-coupled receptor was amplified from a Bombyx mori pheromone gland cDNA library...
  65. ncbi 3xP3-EGFP marker facilitates screening for transgenic silkworm Bombyx mori L. from the embryonic stage onwards
    J L Thomas
    Unité Nationale Séricicole, INRA, 25 quai J J Rousseau, 69350, La Mulatiere, France
    Insect Biochem Mol Biol 32:247-53. 2002
    Transgenesis was recently achieved in Bombyx mori L., but it has proved difficult and time-consuming to screen the numerous progeny to identify the transgenic individuals...
  66. pmc Deep sequencing of small RNA libraries reveals dynamic regulation of conserved and novel microRNAs and microRNA-stars during silkworm development
    Guru Jagadeeswaran
    Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA
    BMC Genomics 11:52. 2010
    In eukaryotes, microRNAs (miRNAs) have emerged as critical regulators of gene expression. The Silkworm (Bombyx mori L...
  67. pmc KAIKObase: an integrated silkworm genome database and data mining tool
    Michihiko Shimomura
    Mitsubishi Space Software Co Ltd, Takezono, Tsukuba, Ibaraki, Japan
    BMC Genomics 10:486. 2009
    The silkworm, Bombyx mori, is one of the most economically important insects in many developing countries owing to its large-scale cultivation for silk production. With the development of genomic and biotechnological tools, B...
  68. ncbi Dosage analysis of Z chromosome genes using microarray in silkworm, Bombyx mori
    Xingfu Zha
    Southwest University, Beibei, Chongqing, China
    Insect Biochem Mol Biol 39:315-21. 2009
    ..These results provide useful clues to further understanding roles of dosage of Z chromosome and some Z-linked sexual differences in silkworms...
  69. ncbi Sequence analysis of the genome of Bombyx mori nucleopolyhedrovirus
    S Gomi
    Department of Entomology, University of California, Davis 95616, USA
    J Gen Virol 80:1323-37. 1999
    The genome of the nucleopolyhedrovirus (NPV) (T3 strain) pathogenic for Bombyx mori (Bm) was sequenced and analysed...
  70. pmc Shotgun analysis on the peritrophic membrane of the silkworm Bombyx mori
    Xiaowu Zhong
    State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China
    BMB Rep 45:665-70. 2012
    ..e. PM chitin-binding protein, invertebrate intestinal mucin, and chitin deacetylase. The protein profile provides a basis for further study of the physiological events in the PM of Bombyx mori.
  71. pmc A role for transcription from a piRNA cluster in de novo piRNA production
    Shinpei Kawaoka
    Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo, Japan
    RNA 18:265-73. 2012
    ..Bioinformatic analyses suggest that the fusion transcript is a source of GFP primary piRNAs. Our data implicate a role for transcription from a piRNA cluster in initiating de novo piRNA production against a new insertion...
  72. ncbi Crystal structure of the 30 K protein from the silkworm Bombyx mori reveals a new member of the β-trefoil superfamily
    Jie Pin Yang
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei Anhui 230027, People s Republic of China
    J Struct Biol 175:97-103. 2011
    The hemolymph of the fifth instar larvae of the silkworm Bombyx mori contains a group of homologous proteins with a molecular weight of approximately 30 kDa, termed B...
  73. ncbi A new method for the modification of fibroin heavy chain protein in the transgenic silkworm
    Katsura Kojima
    National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    Biosci Biotechnol Biochem 71:2943-51. 2007
    ..N-terminal sequencing of HC-EGFP localized the signal sequence cleavage site to between positions A((21)) and N((22)). These results indicate that our new plasmid successfully produced the modified H-chain in a transgenic silkworm...
  74. pmc Proteolytic activation of pro-spätzle is required for the induced transcription of antimicrobial peptide genes in lepidopteran insects
    Yang Wang
    Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA
    Dev Comp Immunol 31:1002-12. 2007
    ..To test whether or not this mechanism exists in lepidopteran insects, we cloned the cDNA of Bombyx mori spätzle-1 and overexpressed the full-length and truncated BmSpz1 cDNA in Escherichia coli...
  75. ncbi A cadherin-like protein functions as a receptor for Bacillus thuringiensis Cry1Aa and Cry1Ac toxins on midgut epithelial cells of Bombyx mori larvae
    Hirotaka Hara
    Graduate School of Bio Applications and Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184 8588, Japan
    FEBS Lett 538:29-34. 2003
    Aminopeptidase N (APN) and cadherin-like protein (BtR175) from Bombyx mori larvae were examined for their roles in Cry1Aa- and Cry1Ac-induced lysis of B. mori midgut epithelial cells (MECs)...
  76. ncbi Autophagy precedes apoptosis during the remodeling of silkworm larval midgut
    Eleonora Franzetti
    Department of Biotechnology and Life Sciences, University of Insubria, Via J H Dunant, 3 21100, Varese, Italy
    Apoptosis 17:305-24. 2012
    ..a cellular, biochemical and molecular analysis of the degeneration process that occurs in the larval midgut of Bombyx mori during larval-adult transformation, with the aim to analyze autophagy and apoptosis in cells that die under ..
  77. ncbi Telomere-specific non-LTR retrotransposons and telomere maintenance in the silkworm, Bombyx mori
    Haruhiko Fujiwara
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Bioscience Building 501, Kashiwano ha, 277 8562 Kashiwa, Japan
    Chromosome Res 13:455-67. 2005
    ..The silkworm, Bombyx mori, retains the TTAGG motifs in the chromosomal ends but expresses quite a low level of telomerase activity in ..
  78. ncbi The N-terminus of B96Bom, a Bombyx mori G-protein-coupled receptor, is N-myristoylated and translocated across the membrane
    Toshihiko Utsumi
    Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753 8515, Japan
    FEBS J 272:472-81. 2005
    ..It was found that the N-terminal 10 residues of B96Bom, a Bombyx mori GPCR, efficiently directed the protein N-myristoylation...
  79. pmc A lipase isolated from the silkworm Bombyx mori shows antiviral activity against nucleopolyhedrovirus
    Kangayam M Ponnuvel
    Innate Immunity Laboratory, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305 8634, Japan
    J Virol 77:10725-9. 2003
    A protein showing strong antiviral activity against Bombyx mori nucleopolyhedrovirus (BmNPV) was purified from the digestive juice of B. mori larvae...
  80. pmc Homeodomain POU and Abd-A proteins regulate the transcription of pupal genes during metamorphosis of the silkworm, Bombyx mori
    Huimin Deng
    Guangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Sciences, South China Normal University, Guangzhou 510631, China
    Proc Natl Acad Sci U S A 109:12598-603. 2012
    ..elements in the promoter of the gene coding for cuticle protein, BmWCP4, and regulate its expression during Bombyx mori metamorphosis...
  81. ncbi PI3K/Akt and MAPK pathways evoke activation of FoxO transcription factor to undergo neuronal apoptosis in brain of the silkworm Bombyx mori (Lepidoptera: Bombycidae)
    J H Kim
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    Cell Mol Biol (Noisy-le-grand) . 2012
    ..PI3K/Akt and mitogen-activated protein kinase (MAPK) pathways in neuronal apoptosis in the brain of the silkworm Bombyx mori following starvation...
  82. pmc Positional cloning of a Bombyx wingless locus flugellos (fl) reveals a crucial role for fringe that is specific for wing morphogenesis
    Kaoru Sato
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Bioscience Building 501, 5 1 5 Kashiwanoha, Kashiwa, Chiba 277 8562, Japan
    Genetics 179:875-85. 2008
    Mutations at the flügellos (fl) locus in Bombyx mori produce wingless pupae and moths because of the repressed response of wing discs to ecdysteroid. Four recessive fl alleles occurred spontaneously and were mapped at 13...
  83. pmc Alternative splicing and trans-splicing events revealed by analysis of the Bombyx mori transcriptome
    Wei Shao
    Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    RNA 18:1395-407. 2012
    Alternative splicing and trans-splicing events have not been systematically studied in the silkworm Bombyx mori. Here, the silkworm transcriptome was analyzed by RNA-seq...
  84. ncbi Computational identification and characteristics of novel microRNAs from the silkworm (Bombyx mori L.)
    Yong Huang
    Jiangsu University of Science and Technology, Zhenjiang City, Jiangsu Province, 212018, People s Republic of China
    Mol Biol Rep 37:3171-6. 2010
    ..Most of these miRNA targeted genes were predicted to encode transcription factors. The semi-stem loop RT-PCR based assays were performed and found that silkworm miRNAs have diverse expression patterns during development...
  85. ncbi Comparative proteomic analysis between the domesticated silkworm (Bombyx mori) reared on fresh mulberry leaves and on artificial diet
    Zhong Hua Zhou
    College of Animal Sciences, Zhejiang University, Hangzhou 310029, PR China
    J Proteome Res 7:5103-11. 2008
    ....
  86. pmc The UDP-glucosyltransferase multigene family in Bombyx mori
    Fei Fei Huang
    The Key Sericultural Laboratory of Agricultural Ministry, Institute of Sericulture and Systems Biology, Southwest University, Chongqing 400715, PR China
    BMC Genomics 9:563. 2008
    ..Identification and characterization of Bombyx mori UGT genes could provide valuable basic information for this important family and explain the detoxication ..
  87. pmc Silkworm expression system as a platform technology in life science
    Tatsuya Kato
    Faculty of Agriculture, Integrated Bioscience Section, Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga ku, Shizuoka, Japan
    Appl Microbiol Biotechnol 85:459-70. 2010
    ..The recent development of a bacmid, Escherichia coli and Bombyx mori shuttle vector, has eliminated the conventional tedious procedures required to identify and isolate ..
  88. ncbi Release of ecdysteroid-phosphates from egg yolk granules and their dephosphorylation during early embryonic development in silkworm, Bombyx mori
    Ryouichi Yamada
    Department of Life and Functional Material Science, Graduate School of Natural Sciences, Konan University, Kobe, Japan
    Zoolog Sci 22:187-98. 2005
    ..In the silkworm Bombyx mori, we previously reported the presence of a specific enzyme, called ecdysteroid-phosphate phosphatase (EPPase), ..
  89. ncbi Molecular characterization of heterochromatin proteins 1a and 1b from the silkworm, Bombyx mori
    H Mitsunobu
    Laboratory of Silkworm Science, Kyushu University Graduate School of Bioresource and Bioenvironmental Sciences, Fukuoka, Japan
    Insect Mol Biol 21:9-20. 2012
    ..These results suggest that silkworm HP1a and HP1b may play different roles in heterochromatin formation in holocentric silkworm chromosomes...
  90. pmc Yellow-e determines the color pattern of larval head and tail spots of the silkworm Bombyx mori
    Katsuhiko Ito
    Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    J Biol Chem 285:5624-9. 2010
    ..In two mutant strains, bts and its allele bts2, of the silkworm Bombyx mori, the larval head cuticle and anal plates are reddish brown instead of the white color found in the wild type...
  91. pmc Genomic sequence around butterfly wing development genes: annotation and comparative analysis
    Inês C Conceição
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    PLoS ONE 6:e23778. 2011
    ..The evolution and development of these patterns is being studied in a few target species, including Bicyclus anynana, where a whole-genome BAC library allows targeted access to large genomic regions...
  92. pmc The Bombyx ovary-derived cell line endogenously expresses PIWI/PIWI-interacting RNA complexes
    Shinpei Kawaoka
    Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    RNA 15:1258-64. 2009
    ..Here we report that Bombyx mori ovary-derived cultured cell line, BmN4, endogenously expresses two PIWI subfamily proteins, silkworm Piwi (..
  93. pmc Burst expansion, distribution and diversification of MITEs in the silkworm genome
    Min Jin Han
    The Key Sericultural Laboratory of Agricultural Ministry, Southwest University, Chongqing 400715, China
    BMC Genomics 11:520. 2010
    Miniature inverted-repeat transposable elements (MITEs) are widespread in plants and animals. Although silkworm (Bombyx mori) has a large amount of and a variety of transposable elements, the genome-wide information of the silkworm MITEs ..
  94. ncbi Effects of neuropeptides on feeding initiation in larvae of the silkworm, Bombyx mori
    Shinji Nagata
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Gen Comp Endocrinol 172:90-5. 2011
    ..mechanism in feeding behavior, we tested the effects of several biologically active peptides on silkworm, Bombyx mori larvae feeding behaviors...
  95. ncbi Involvement of PI3K/Akt signaling in PTTH-stimulated ecdysteroidogenesis by prothoracic glands of the silkworm, Bombyx mori
    Shi Hong Gu
    Department of Zoology, National Museum of Natural Science, 1 Kuan Chien Road, Taichung 404, Taiwan, ROC
    Insect Biochem Mol Biol 41:197-202. 2011
    ..ERK), and tyrosine kinase are involved in PTTH-stimulated ecdysteroidogenesis by the prothoracic glands of both Bombyx mori and Manduca sexta...
  96. ncbi Caterpillar color patterns are determined by a two-phase melanin gene prepatterning process: new evidence from tan and laccase2
    Ryo Futahashi
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba, Japan
    Evol Dev 12:157-67. 2010
    ..Moreover, the silkworm Bombyx mori is most suitable for identification of lab-generated color mutants because genome information and many color ..
  97. ncbi Identification and characterization of Polycomb group genes in the silkworm, Bombyx mori
    Zhiqing Li
    Laboratory of Silkworm Science, Kyushu University Graduate School of Bioresource and Bioenvironmental Sciences, Hakozaki 6 10 1, Fukuoka, 812 8581, Japan
    Mol Biol Rep 39:5575-88. 2012
    ..To characterize the orthologs of PcG genes in the silkworm, Bombyx mori, 13 candidates were identified from the updated silkworm genome sequence by using the fruit fly PcG genes as ..
  98. ncbi Nuclear receptors in Bombyx mori: insights into genomic structure and developmental expression
    Daojun Cheng
    The Key Sericultural Laboratory of Agricultural Ministry, Southwest University, Chongqing, China
    Insect Biochem Mol Biol 38:1130-7. 2008
    ..The updated assembly of complete genome sequence of the Bombyx mori enabled a systematic analysis of the NRs in the five holometabolous insects including B...
  99. ncbi Porous 3-D scaffolds from regenerated silk fibroin
    Rina Nazarov
    Department of Biomedical Engineering and Chemical and Biological Engineering, Tufts University, Bioengineering Center, 4 Colby Street, Medford, Massachusetts 02155, USA
    Biomacromolecules 5:718-26. 2004
    ..The results suggest that silk-based 3D matrixes can be formed for utility in biomaterial applications...
  100. pmc Mutations of an arylalkylamine-N-acetyltransferase, Bm-iAANAT, are responsible for silkworm melanism mutant
    Fang yin Dai
    College of Biotechnology, Institute of Sericulture and Systems Biology, Southwest University, Chongqing 400715, China
    J Biol Chem 285:19553-60. 2010
    ..To our knowledge, this is the first report showing a role for arylalkylamine-N-acetyltransferases in color pattern mutation in Lepidoptera...
  101. ncbi Disruption of an N-acetyltransferase gene in the silkworm reveals a novel role in pigmentation
    Shuai Zhan
    Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Development 137:4083-90. 2010
    ..The melanism (mln) mutant of the silkworm Bombyx mori is notable for its strong black coloration, phenotypic differences between larval and adult stages, and its ..

Research Grants32

  1. A novel transgenic silkworm system for recombinant glycoprotein production
    Donald L Jarvis; Fiscal Year: 2010
    ..Finally, these results will be of great interest to bioengineers working to overcome the evolutionary limitations of lower eukaryotic systems for recombinant glycoprotein production. ..
  2. Molecular Physiology of the Epitrachael Endocrine System
    Michael E Adams; Fiscal Year: 2012
    ..specific peptidergic ensembles to test their necessary roles in the ecdysis sequence in Drosophila, Aedes, and Bombyx. The third specific aim is to elucidate how the ETH-activated central peptide signaling cascade mediates ..
  3. Functions of MOV10L1 in piRNA biogenesis and germ cell development
    Peijing Jeremy Wang; Fiscal Year: 2013
    ..and 3) biochemically characterize the role of the MOV10L1 homologue in piRNA biogenesis in cultured silkworm (Bombyx mori) BmN4 ovarian cell lines...
  4. Circadian Clock: Differential Cryptochrome Functions
    Steven M Reppert; Fiscal Year: 2011
    ..in vivo the critical clockwork function of insect CRY2 by targeted gene inactivation in the commercial silkworm Bombyx mori using a zinc finger nuclease strategy...
  5. piRNA biogenesis ruled by PIWI-TUDOR interaction
    Yohei Kirino; Fiscal Year: 2013
    ..function of PIWI sDMAs in the piRNA pathway, we will express PIWI proteins containing or lacking sDMAs in BmN4 (a Bombyx mori ovary-derived cultured cell line) that is an excellent cell system for piRNA research due to its endogenous ..
  6. Convergent Molecular Evolution of Moth and Spider Silks
    NADIA AYOUB; Fiscal Year: 2009
    ..These artificial silks can then be used in biomedical applications, such as artificial ligaments or tendons and incredibly thin but strong sutures. ..
  7. MOLECULAR PHYSIOLOGY OF THE EPITRACHEAL ENDOCRINE SYSTEM
    Michael Adams; Fiscal Year: 2002
    ..We have identified ecdysis-triggering hormones (ETHs) in flies (Drosophila, Musca) and moths (Manduca, Bombyx), demonstrated their functional roles in regulating in the ecdysis sequence, and established that ETH is ..
  8. Recombinant Subunit Protein for Flu Vaccine
    Carolyn Weeks Levy; Fiscal Year: 2006
    ..The proteins will also be expressed in the Bombyx mori system to provide Hawaii Biotech Inc an alternative expression system to the Drosophila system...
  9. CONTROL OF TRNA GENE EXPRESSION IN BOMBYX MORI
    KAREN SPRAGUE; Fiscal Year: 1993
    ....
  10. MULTIGENE FAMILIES: STRUCTURE, EXPRESSION AND EVOLUTION
    Thomas Eickbush; Fiscal Year: 1991
    ..of the chorion (eggshell) by the monolayer of follicle cells surrounding the maturing oocyte of the silkmoth, Bombyx mori...
  11. SILK SCAFFOLDS FOR BONE FORMATION
    David Kaplan; Fiscal Year: 2003
    ....
  12. COMPARATIVE ANALYSIS OF CLOCK GENES
    STEVEN REPPERT; Fiscal Year: 2001
    ..Increased understanding of the fundamental mechanisms of biological clock function will facilitate the development of better treatment strategies for a wide range of disorders. ..
  13. REGULATION OF AMINOACYL-TRNA SYNTHETASES IN BOMBYX
    DAVID DIGNAM; Fiscal Year: 1990
    ..studies will be to determine how the levels of aminoacyl-tRNA synthetases are regulated in a higher eukaryote, Bombyx mori...
  14. MECHANISM OF SELECTIVE EXPRESSION OF TRNA GENES
    KAREN SPRAGUE; Fiscal Year: 1999
    ....
  15. EUKARYOTIC GENE ISOLATION AND EXPRESSION
    John Morrow; Fiscal Year: 1980
    We propose to learn whether putative transposable elements, which are repeated DNA sequences of Bombyx mori, have the sequence at one end duplicated at the other end...
  16. Gustatory and olfactory receptors of Anopheles gambiae
    Hugh Robertson; Fiscal Year: 2006
    ..This work will also contribute to our overall understanding of the molecular basis of chemoreception in insects and other animals. [unreadable] [unreadable]..
  17. MARINER TRANSPOSONS OF MAMMALS
    Hugh Robertson; Fiscal Year: 2001
    ..It will also reveal how occasionally particular copies of transposons can become integral parts of their host genetic complements. ..
  18. Mosquito Immunity to Alphaviruses
    Brian Foy; Fiscal Year: 2006
    ..3) Characterize the mechanisms that Culex tritaeniorhynchus mosquitoes use to clear Sindbis virus-infected midgut cells. [unreadable] [unreadable]..
  19. INSECT HEME OXYGENASE
    Boris Dunkov; Fiscal Year: 2004
    ..The organ specific expression will be studied in larvae and in female mosquitoes at various stages before and after blood feeding. ..
  20. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  21. Function of Laccases in Anopheles gambiae
    Michael R Kanost; Fiscal Year: 2010
    ..Disrupting laccase function may provide a new mechanism for controlling mosquito populations. ..
  22. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  23. Cardioprotective Repair through Cardiopoiesis
    Andre Terzic; Fiscal Year: 2010
    ..abstract_text> ..
  24. PROTEINASE SYSTEMS IN INSECT HEMOLYMPH
    Michael R Kanost; Fiscal Year: 2010
    ..sexta, to apply this knowledge to insect vectors of human diseases, and to apply advantages of the M. sexta system for fundamental studies on the regulation of serine protease activity. ..
  25. Pilot Studies in Biochemistry of Anopheles gambiae
    Michael Kanost; Fiscal Year: 2005
    ..gambiae serpins and laccases. This project will be a start toward development of a new research area for the PI (mosquito biochemistry) that will build from his experience in biochemistry of other groups of insects. ..
  26. Cocaine and monoamine transporters
    HOWARD GU; Fiscal Year: 2009
    ..These compounds would be excellent drug candidates for the development of pharmacological treatment for cocaine addiction. ..
  27. Functional Characterization of Drosophila Odor Receptors
    ELISSA HALLEM; Fiscal Year: 2005
    ..The contribution of individual odor receptors to receptor neuron response properties will be examined, thus furthering our understanding of both olfactory coding and the molecular basis of odor-receptor interactions. ..
  28. Cardiac KATP Channels in Health and Disease
    Andre Terzic; Fiscal Year: 2007
    ..Thus, this proposal will provide an integrated understanding of cardiac KATP channels in metabolic signal decoding, stress adaptation, and their impact for clinical medicine. ..
  29. TRANSGENIC ENGINEERING OF AEDINE MOSQUITOES
    Malcolm Fraser; Fiscal Year: 2005
    ..This research will provide an exciting and much needed capability for significant enhancement of the basic research effort in mosquito genetics and physiology. ..
  30. Biomimetic Scaffolds for Abdominal Wall Repair
    Anshu Mathur; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..