butterflies

Summary

Summary: Slender-bodies diurnal insects having large, broad wings often strikingly colored and patterned.

Top Publications

  1. pmc Ten species in one: DNA barcoding reveals cryptic species in the neotropical skipper butterfly Astraptes fulgerator
    Paul D N Hebert
    Department of Zoology, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Proc Natl Acad Sci U S A 101:14812-7. 2004
  2. pmc The monarch butterfly genome yields insights into long-distance migration
    Shuai Zhan
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Cell 147:1171-85. 2011
  3. pmc A large-scale, higher-level, molecular phylogenetic study of the insect order Lepidoptera (moths and butterflies)
    Jerome C Regier
    Institute for Bioscience and Biotechnology Research, University of Maryland, College Park, Maryland, USA
    PLoS ONE 8:e58568. 2013
  4. pmc Chromosomal rearrangements maintain a polymorphic supergene controlling butterfly mimicry
    Mathieu Joron
    CNRS UMR 7205, Museum national d histoire naturelle, CP50, 45 rue Buffon, 75005 Paris, France
    Nature 477:203-6. 2011
  5. pmc Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand
    Arnaud Martin
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 109:12632-7. 2012
  6. ncbi The complete mitochondrial genome of the tobacco hornworm, Manduca sexta, (Insecta: Lepidoptera: Sphingidae), and an examination of mitochondrial gene variability within butterflies and moths
    Stephen L Cameron
    Australian National Insect Collection and CSIRO Entomology, Black Mountain Laboratories, Canberra, ACT, Australia
    Gene 408:112-23. 2008
  7. ncbi optix drives the repeated convergent evolution of butterfly wing pattern mimicry
    Robert D Reed
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Science 333:1137-41. 2011
  8. pmc Adaptive introgression across species boundaries in Heliconius butterflies
    Carolina Pardo-Diaz
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 8:e1002752. 2012
  9. ncbi A draft sequence for the genome of the domesticated silkworm (Bombyx mori)
    Qingyou Xia
    Southwest Agricultural University, Chongqing Beibei, 400716, China
    Science 306:1937-40. 2004
  10. pmc Timing and patterns in the taxonomic diversification of Lepidoptera (butterflies and moths)
    Niklas Wahlberg
    Department of Biology, University of Turku, Turku, Finland
    PLoS ONE 8:e80875. 2013

Research Grants

  1. The Biodemographic Determinants of Life Span
    James R Carey; Fiscal Year: 2010
  2. Biomarkers of Interoceptive Awareness in Adolescent Anorexia Nervosa
    NANCY L contact ZUCKER; Fiscal Year: 2010
  3. Exploring the Venom Repertoire of Parasitoids
    JOHN HAYNES WERREN; Fiscal Year: 2013
  4. Circadian Clock: Differential Cryptochrome Functions
    Steven M Reppert; Fiscal Year: 2011
  5. The Development Genetics of Butterfly Wing Patterns
    ANDREW STOEHR; Fiscal Year: 2009
  6. COMPARATIVE ANALYSIS OF CLOCK GENES
    STEVEN REPPERT; Fiscal Year: 2001
  7. Circadian Clock: Transcriptional Control
    STEVEN REPPERT; Fiscal Year: 2008
  8. MATERNAL INFLUENCE ON DEVELOPING 24-HOUR PERIODICITY
    STEVEN REPPERT; Fiscal Year: 2002
  9. CIRCADIAN CLOCK MECHANISM IN THE SCN
    STEVEN REPPERT; Fiscal Year: 2004
  10. LONGEVITY/CANDIDATE GENE POLYMORPHISMS IN DROSOPHILA
    Marc Tatar; Fiscal Year: 2003

Detail Information

Publications291 found, 100 shown here

  1. pmc Ten species in one: DNA barcoding reveals cryptic species in the neotropical skipper butterfly Astraptes fulgerator
    Paul D N Hebert
    Department of Zoology, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Proc Natl Acad Sci U S A 101:14812-7. 2004
    ..They also illustrate the value of DNA barcoding, especially when coupled with traditional taxonomic tools, in disclosing hidden diversity...
  2. pmc The monarch butterfly genome yields insights into long-distance migration
    Shuai Zhan
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Cell 147:1171-85. 2011
    ..of oriented flight behavior; microRNAs that are differentially expressed between summer and migratory butterflies; monarch-specific expansions of chemoreceptors potentially important for long-distance migration; and a variant ..
  3. pmc A large-scale, higher-level, molecular phylogenetic study of the insect order Lepidoptera (moths and butterflies)
    Jerome C Regier
    Institute for Bioscience and Biotechnology Research, University of Maryland, College Park, Maryland, USA
    PLoS ONE 8:e58568. 2013
    ..We present the most comprehensive molecular analysis of lepidopteran phylogeny to date, focusing on relationships among superfamilies...
  4. pmc Chromosomal rearrangements maintain a polymorphic supergene controlling butterfly mimicry
    Mathieu Joron
    CNRS UMR 7205, Museum national d histoire naturelle, CP50, 45 rue Buffon, 75005 Paris, France
    Nature 477:203-6. 2011
    ..These findings highlight how genomic rearrangements can have a central role in the coexistence of adaptive phenotypes involving several genes acting in concert, by locally limiting recombination and gene flow...
  5. pmc Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand
    Arnaud Martin
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 109:12632-7. 2012
    ..Here we take advantage of the extensive diversity of Heliconius butterflies to identify a gene that causes adaptive variation of black wing patterns within and between species...
  6. ncbi The complete mitochondrial genome of the tobacco hornworm, Manduca sexta, (Insecta: Lepidoptera: Sphingidae), and an examination of mitochondrial gene variability within butterflies and moths
    Stephen L Cameron
    Australian National Insect Collection and CSIRO Entomology, Black Mountain Laboratories, Canberra, ACT, Australia
    Gene 408:112-23. 2008
    ....
  7. ncbi optix drives the repeated convergent evolution of butterfly wing pattern mimicry
    Robert D Reed
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Science 333:1137-41. 2011
    ..Here, we characterize one of the major genes responsible for mimetic wing pattern evolution in Heliconius butterflies. Mapping, gene expression, and population genetic work all identify a single gene, optix, that controls extreme ..
  8. pmc Adaptive introgression across species boundaries in Heliconius butterflies
    Carolina Pardo-Diaz
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 8:e1002752. 2012
    ..we have examined the role of introgressive hybridisation in transferring adaptations between mimetic Heliconius butterflies, taking advantage of the recent identification of a gene regulating red wing patterns in this genus...
  9. ncbi A draft sequence for the genome of the domesticated silkworm (Bombyx mori)
    Qingyou Xia
    Southwest Agricultural University, Chongqing Beibei, 400716, China
    Science 306:1937-40. 2004
    ..Our estimated gene count is 18,510, which exceeds the 13,379 genes reported for Drosophila melanogaster. Comparative analyses to fruitfly, mosquito, spider, and butterfly reveal both similarities and differences in gene content...
  10. pmc Timing and patterns in the taxonomic diversification of Lepidoptera (butterflies and moths)
    Niklas Wahlberg
    Department of Biology, University of Turku, Turku, Finland
    PLoS ONE 8:e80875. 2013
    ..Almost all extant families appear to have begun diversifying soon after the Cretaceous/Paleogene event 65.51 mya. ..
  11. pmc The biological impacts of the Fukushima nuclear accident on the pale grass blue butterfly
    Atsuki Hiyama
    The BCPH Unit of Molecular Physiology, Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, Nishihara, Okinawa 903 0213, Japan
    Sci Rep 2:570. 2012
    ..Adult butterflies collected in September 2011 showed more severe abnormalities than those collected in May...
  12. ncbi Herbivory: caterpillar saliva beats plant defences
    Richard O Musser
    Department of Entomology, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Nature 416:599-600. 2002
    ..We find that the enzyme glucose oxidase counteracts the production of nicotine induced by the caterpillar feeding on the plant...
  13. pmc Oviposition by pierid butterflies triggers defense responses in Arabidopsis
    Dawn Little
    Department of Plant Molecular Biology, University of Lausanne, 1015 Lausanne, Switzerland
    Plant Physiol 143:784-800. 2007
    ..we studied the expression profile of Arabidopsis (Arabidopsis thaliana) leaves after oviposition by two pierid butterflies. For Pieris brassicae, the deposition of egg batches changed the expression of hundreds of genes over a period ..
  14. ncbi The ecology and evolution of ant association in the Lycaenidae (Lepidoptera)
    Naomi E Pierce
    Museum of Comparative Zoology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Entomol 47:733-71. 2002
    ..Further research on phylogeny and natural history, particularly of the Neotropical fauna, will be necessary to understand the role ant association has played in the evolution of the Lycaenidae...
  15. ncbi Ecological and evolutionary processes at expanding range margins
    C D Thomas
    Centre for Biodiversity and Conservation, School of Biology, University of Leeds, Leeds LS2 9JT, UK
    Nature 411:577-81. 2001
    ..The emergence of dispersive phenotypes will increase the speed at which species invade new environments, and probably underlies the responses of many species to both past and future climate change...
  16. pmc The joint evolutionary histories of Wolbachia and mitochondria in Hypolimnas bolina
    Sylvain Charlat
    CNRS UMR 5558, University of Lyon 1, Laboratoire de Biometrie et Biologie Evolutive, Batiment Mendel, Villeurbanne, France
    BMC Evol Biol 9:64. 2009
    ....
  17. ncbi Bayesian analysis of molecular variance in pyrosequences quantifies population genetic structure across the genome of Lycaeides butterflies
    Zachariah Gompert
    Department of Botany, Program in Ecology, University of Wyoming, Laramie, WY 82071, USA
    Mol Ecol 19:2455-73. 2010
    ..This study demonstrates the potential of using genome-level data to better understand the phylogeographic history of populations...
  18. pmc Genomic hotspots for adaptation: the population genetics of Müllerian mimicry in Heliconius erato
    Brian A Counterman
    Department of Genetics, North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS Genet 6:e1000796. 2010
    Wing pattern evolution in Heliconius butterflies provides some of the most striking examples of adaptation by natural selection...
  19. ncbi Rapid responses of British butterflies to opposing forces of climate and habitat change
    M S Warren
    Butterfly Conservation, Manor Yard, East Lulworth, Wareham, Dorset BH20 5QP, UK
    Nature 414:65-9. 2001
    ..Here we evaluated changes in the distribution sizes and abundances of 46 species of butterflies that approach their northern climatic range margins in Britain-where changes in climate and habitat are ..
  20. ncbi The evolution of alternative parasitic life histories in large blue butterflies
    Thomas D Als
    Department of Ecology and Genetics, University of Aarhus, Ny Munkegade, 8000 Aarhus C, Denmark
    Nature 432:386-90. 2004
    Large blue (Maculinea) butterflies are highly endangered throughout the Palaearctic region, and have been the focus of intense conservation research...
  21. pmc Genome-wide evidence for speciation with gene flow in Heliconius butterflies
    Simon H Martin
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom
    Genome Res 23:1817-28. 2013
    ..Here we use new methodology to quantify admixture at different stages of divergence in Heliconius butterflies, based on whole-genome sequences of 31 individuals...
  22. ncbi Lack of genetic differentiation between monarch butterflies with divergent migration destinations
    Justine I Lyons
    Department of Biology, 1510 Clifton Road, Atlanta, GA 20322, USA
    Mol Ecol 21:3433-44. 2012
    Monarch butterflies are best known for their spectacular annual migration from eastern North America to Mexico...
  23. ncbi Phylogenetic relationships of true butterflies (Lepidoptera: Papilionoidea) inferred from COI, 16S rRNA and EF-1α sequences
    Man Il Kim
    College of Agriculture and Life Sciences, Chonnam National University, Gwangju, 500 757, Korea
    Mol Cells 30:409-25. 2010
    ....
  24. pmc Navigational mechanisms of migrating monarch butterflies
    Steven M Reppert
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Trends Neurosci 33:399-406. 2010
    Recent studies of the iconic fall migration of monarch butterflies have illuminated the mechanisms behind their southward navigation while using a time-compensated sun compass...
  25. ncbi Ectopic gene expression and homeotic transformations in arthropods using recombinant Sindbis viruses
    D L Lewis
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, University of Wisconsin, Madison, 53706, USA
    Curr Biol 9:1279-87. 1999
    ..Direct analysis of how a particular gene functions in a given species during development is hindered by the lack of broadly applicable techniques for manipulating gene expression...
  26. ncbi The evolution of wing color: male mate choice opposes adaptive wing color divergence in Colias butterflies
    Jacintha Ellers
    Center for Conservation Biology, Department of Biological Sciences, 371 Serra Mall, Stanford University, Stanford, California 94305 5020, USA
    Evolution 57:1100-6. 2003
    ..performed controlled mate choice experiments in the field over an elevational range of 1500 meters using decoy butterflies with different melanization levels...
  27. pmc A single origin for nymphalid butterfly eyespots followed by widespread loss of associated gene expression
    Jeffrey C Oliver
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America
    PLoS Genet 8:e1002893. 2012
    ..The eyespot of nymphalid butterflies has served as an example of a novel complex trait, as multiple genes are expressed during eyespot development...
  28. pmc Environmental effects on temperature stress resistance in the tropical butterfly Bicyclus anynana
    Klaus Fischer
    Zoological Institute and Museum, University of Greifswald, Greifswald, Germany
    PLoS ONE 5:e15284. 2010
    ..Thus, organisms need to employ effective mechanisms to ensure survival under stressful thermal conditions, among which phenotypic plasticity is considered a particularly quick and effective one...
  29. ncbi Convergent, modular expression of ebony and tan in the mimetic wing patterns of Heliconius butterflies
    Laura C Ferguson
    Department of Zoology, University of Cambridge, Downing Street, Cambridge, UK CB2 3EJ
    Dev Genes Evol 221:297-308. 2011
    ..Here, we study insect melanin synthesis genes in Heliconius butterflies, a group characterised by its diversity of wing patterns consisting of black (melanin), and yellow and red (..
  30. pmc Comparative insights into questions of lepidopteran wing pattern homology
    Antonia Monteiro
    Department of Biological Sciences, University at Buffalo, 109 Cooke Hall, Buffalo, NY 14260, USA
    BMC Dev Biol 6:52. 2006
    ..Within the butterflies, on the other hand, spots that share the same homologous position may not share the concentric ring structure; ..
  31. pmc Single locus affects embryonic segment polarity and multiple aspects of an adult evolutionary novelty
    Suzanne V Saenko
    Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands
    BMC Biol 8:111. 2010
    ..Here we describe three pleiotropic mutations with large effects on a novel trait, butterfly eyespots, and on a conserved stage of embryogenesis, segment polarity...
  32. pmc Dissecting comimetic radiations in Heliconius reveals divergent histories of convergent butterflies
    Swee Peck Quek
    Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 107:7365-70. 2010
    Mimicry among Heliconius butterflies provides a classic example of coevolution but unresolved relationships among mimetic subspecies have prevented examination of codiversification between species...
  33. pmc Polymorphic butterfly reveals the missing link in ecological speciation
    Nicola L Chamberlain
    Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA
    Science 326:847-50. 2009
    ..genetics, we studied a butterfly population with a mimetic wing color polymorphism and found that the butterflies exhibited partial, color-based, assortative mate preference...
  34. ncbi Host-parasite genetic interactions and virulence-transmission relationships in natural populations of monarch butterflies
    Jacobus C de Roode
    Department of Biology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Evolution 64:502-14. 2010
    ..We conducted a cross-infection experiment using monarch butterflies and their protozoan parasites from two populations in eastern and western North America...
  35. ncbi Specialization and geographic isolation among Wolbachia symbionts from ants and lycaenid butterflies
    Jacob A Russell
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Evolution 63:624-40. 2009
    ..and their hosts, we surveyed global collections of two diverse families of insects, the ants and lycaenid butterflies. In total, 54 Wolbachia isolates were typed using a Multi Locus Sequence Typing (MLST) approach, in which five ..
  36. pmc Linkage of butterfly mate preference and wing color preference cue at the genomic location of wingless
    Marcus R Kronforst
    Section of Integrative Biology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:6575-80. 2006
    ..Heliconius butterflies, well known for their diversity of wing color patterns, mate assortatively as a result of divergence in male ..
  37. pmc Genomic islands of divergence in hybridizing Heliconius butterflies identified by large-scale targeted sequencing
    Nicola J Nadeau
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    Philos Trans R Soc Lond B Biol Sci 367:343-53. 2012
    Heliconius butterflies represent a recent radiation of species, in which wing pattern divergence has been implicated in speciation...
  38. ncbi The generation and diversification of butterfly eyespot color patterns
    C R Brunetti
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin-Madison, 1525 Linden Drive, Madison, WI 53706, USA
    Curr Biol 11:1578-85. 2001
    ..Furthermore, the remarkably plastic regulatory interactions downstream of focal signaling have facilitated the evolution of eyespot diversity...
  39. ncbi Sex chromosomes and sex determination in Lepidoptera
    W Traut
    Universitat Lubeck, Zentrum fur Medizinische Strukturbiologie, Institut fur Biologie, Lubeck, Germany
    Sex Dev 1:332-46. 2007
    The speciose insect order Lepidoptera (moths and butterflies) and their closest relatives, Trichoptera (caddis flies), share a female-heterogametic sex chromosome system...
  40. pmc Genomic hotspots for adaptation: the population genetics of Müllerian mimicry in the Heliconius melpomene clade
    Simon W Baxter
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 6:e1000794. 2010
    Wing patterning in Heliconius butterflies is a longstanding example of both Müllerian mimicry and phenotypic radiation under strong natural selection...
  41. pmc Maternal effects, flight versus fecundity trade-offs, and offspring immune defence in the speckled wood butterfly, Pararge aegeria
    Melanie Gibbs
    Behavioural Ecology and Conservation Group, Biodiversity Research Centre, Earth and Life Institute, Universite Catholique de Louvain UCL, Louvain la Neuve, Belgium
    BMC Evol Biol 10:345. 2010
    ....
  42. ncbi Insect eggs suppress plant defence against chewing herbivores
    Friederike Bruessow
    Department of Plant Molecular Biology, University of Lausanne, CH 1015 Lausanne, Switzerland
    Plant J 62:876-85. 2010
    ..We show here that egg-induced SA accumulation negatively interferes with the JA pathway, and provides an advantage for generalist herbivores...
  43. ncbi Assay conditions in laboratory experiments: is the use of constant rather than fluctuating temperatures justified when investigating temperature-induced plasticity?
    Klaus Fischer
    Zoological Institute and Museum, University of Greifswald, Greifswald, Germany
    Oecologia 166:23-33. 2011
    ..Thus, overall, fluctuating temperatures were more beneficial to the butterflies compared to constant ones...
  44. pmc A gene-based linkage map for Bicyclus anynana butterflies allows for a comprehensive analysis of synteny with the lepidopteran reference genome
    Patricia Beldade
    Institute of Biology, Leiden University, Leiden, The Netherlands
    PLoS Genet 5:e1000366. 2009
    Lepidopterans (butterflies and moths) are a rich and diverse order of insects, which, despite their economic impact and unusual biological properties, are relatively underrepresented in terms of genomic resources...
  45. ncbi Male sex pheromone release and female mate choice in a butterfly
    Johan Andersson
    KTH, School of Chemistry and Engineering, Department of Chemistry, Organic Chemistry, Ecological Chemistry Group, SE 100 44 Stockholm, Sweden
    J Exp Biol 210:964-70. 2007
    In butterflies female mate choice is influenced by both visual and olfactory cues, the latter of which are important at close range...
  46. ncbi Molecular phylogeny, historical biogeography, and divergence time estimates for swallowtail butterflies of the genus Papilio (Lepidoptera: Papilionidae)
    Evgueni V Zakharov
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    Syst Biol 53:193-215. 2004
    Swallowtail butterflies are recognized as model organisms in ecology, evolutionary biology, genetics, and conservation biology but present numerous unresolved phylogenetic problems...
  47. pmc Investigating concordance among genetic data, subspecies circumscriptions and hostplant use in the nymphalid butterfly Polygonia faunus
    Ullasa Kodandaramaiah
    Department of Zoology, Stockholm University, Stockholm, Sweden
    PLoS ONE 7:e41058. 2012
    ..The results of this study will be crucial in designing further experiments to understand the evolution of hostplant utilization in this species...
  48. ncbi Pattern formation and eyespot determination in butterfly wings
    S B Carroll
    Howard Hughes Medical Institute, Madison, WI
    Science 265:109-14. 1994
    ..specifies positional information with respect to the entire wing field and is conserved between fruit flies and butterflies. A second system, superimposed on the general system and involving several of the same genes, operates within ..
  49. ncbi Climate change can cause spatial mismatch of trophically interacting species
    Oliver Schweiger
    Helmholtz Centre for Environmental Research UFZ, Department of Community Ecology, Theodor Lieser Str 4, D 06210 Halle, Germany
    Ecology 89:3472-9. 2008
    ....
  50. ncbi Evolutionary biology: butterfly mimics of ants
    Jeremy A Thomas
    Nature 432:283-4. 2004
  51. pmc Antennal circadian clocks coordinate sun compass orientation in migratory monarch butterflies
    Christine Merlin
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 325:1700-4. 2009
    During their fall migration, Eastern North American monarch butterflies (Danaus plexippus) use a time-compensated Sun compass to aid navigation to their overwintering grounds in central Mexico...
  52. pmc Beyond climate envelopes: effects of weather on regional population trends in butterflies
    Michiel F Wallisdevries
    De Vlinderstichting Dutch Butterfly Conservation, Wageningen, The Netherlands
    Oecologia 167:559-71. 2011
    ..Our results underline the challenge to include population trends in predicting range shifts in response to climate change...
  53. ncbi What causes latitudinal gradients in species diversity? Evolutionary processes and ecological constraints on swallowtail biodiversity
    Fabien L Condamine
    INRA, UMR Centre de Biologie pour la Gestion des Populations, CBGP INRA IRD CIRAD Montpellier SupAgro, Campus International de Baillarguet, 34988 Montferrier sur Lez, France
    Ecol Lett 15:267-77. 2012
    ..to investigate the ecological and evolutionary processes responsible for the global LDG observed in swallowtail butterflies (Papilionidae)...
  54. ncbi Unconventional lift-generating mechanisms in free-flying butterflies
    R B Srygley
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Nature 420:660-4. 2002
    ..To investigate these mechanisms of force generation, we trained red admiral butterflies, Vanessa atalanta, to fly freely to and from artificial flowers in a wind tunnel, and used high-resolution, ..
  55. ncbi Controlled replication of butterfly wings for achieving tunable photonic properties
    Jingyun Huang
    School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0245, USA
    Nano Lett 6:2325-31. 2006
    ....
  56. ncbi Flight metabolic rate and Pgi genotype influence butterfly dispersal rate in the field
    Kristjan Niitepõld
    Department of Biological and Environmental Sciences, P O Box 65 Viikinkaari 1, University of Helsinki, Helsinki FI 00014, Finland
    Ecology 90:2223-32. 2009
    ..We used harmonic radar to track free-flying Glanville fritillary butterflies (Melitaea cinxia) released in the field and reconstructed their flight tracks for several hours...
  57. ncbi Strength in numbers: high parasite burdens increase transmission of a protozoan parasite of monarch butterflies (Danaus plexippus)
    Jacobus C de Roode
    Biology Department, Emory University, Atlanta, GA 30322, USA
    Oecologia 161:67-75. 2009
    ..We studied the protozoan Ophryocystis elektroscirrha, a common parasite of monarch butterflies (Danaus plexippus), to quantify the benefits of high parasite burdens for parasite transmission...
  58. ncbi Male-killing bacteria trigger a cycle of increasing male fatigue and female promiscuity
    Sylvain Charlat
    Department of Biology, University College London, 4 Stephenson Way, London NW1 2HE, United Kingdom
    Curr Biol 17:273-7. 2007
    ..In other words, this system is one where male-killing bacteria trigger a vicious circle of increasing male fatigue and female promiscuity...
  59. ncbi The two CRYs of the butterfly
    Haisun Zhu
    Curr Biol 15:R953-4. 2005
  60. ncbi Complete mitogenome of the Lesser Purple Emperor Apatura ilia (Lepidoptera: Nymphalidae: Apaturinae) and comparison with other nymphalid butterflies
    Mei Chen
    Anhui Normal University, Wuhu Anhui, China
    Dongwuxue Yanjiu 33:191-201. 2012
    ..The 403 bp AT-rich region harbored two conserved motifs (ATAGA, ATTTA), a 21 bp polyT stretch, a 10 bp poly-A region, along with two microsatellite-like repeats ( (TA)(10) and (TA)(7)), as detected in other nymphalid butterflies.
  61. ncbi A phylogenetic revision of the Glaucopsyche section (Lepidoptera: Lycaenidae), with special focus on the Phengaris-Maculinea clade
    L V Ugelvig
    Centre for Social Evolution, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Mol Phylogenet Evol 61:237-43. 2011
    Despite much research on the socially parasitic large blue butterflies (genus Maculinea) in the past 40 years, their relationship to their closest relatives, Phengaris, is controversial and the relationships among the remaining genera in ..
  62. ncbi Out of the Andes: patterns of diversification in clearwing butterflies
    M Elias
    NERC Centre for Population Biology, Imperial College London, Silwood Park Campus, Ascot, UK
    Mol Ecol 18:1716-29. 2009
    ..Here we study the role of the Andes in the evolution of a diverse Neotropical insect group, the clearwing butterflies. We used dated species-level phylogenies to investigate the time course of speciation and to infer ancestral ..
  63. ncbi Feminization of genetic males by a symbiotic bacterium in a butterfly, Eurema hecabe (Lepidoptera: Pieridae)
    Masato Hiroki
    Department of Biology, International Christian University, Mitaka, Tokyo, Japan
    Naturwissenschaften 89:167-70. 2002
    ..Cytological observations showed that thelygenic females lack the sex chromatin body (W chromosome). The results strongly suggest that the sex-ratio distortion in E. hecabe is due to feminization of genetic males by Wolbachia...
  64. ncbi Species-specific coordinated gene expression and trans-regulation of larval color pattern in three swallowtail butterflies
    Hiroko Shirataki
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Bioscience Building 501, 5 1 5 Kashiwanoha, Kashiwa, Chiba 277 8562, Japan
    Evol Dev 12:305-14. 2010
    ..The final instar larvae of the swallowtail butterflies Papilio xuthus and Papilio polytes show a green camouflage pattern, whereas those of Papilio machaon show a ..
  65. ncbi Insect egg deposition induces indirect defense and epicuticular wax changes in Arabidopsis thaliana
    Beatrice Blenn
    Institute of Biology, Freie Universitat Berlin, Berlin, Germany
    J Chem Ecol 38:882-92. 2012
    ..brassicae egg parasitoids. (b) Application of ARG secretion of mated female butterflies or of BC to leaves had the same inductive effects as egg deposition...
  66. ncbi Heterogeneous landscapes promote population stability
    Tom Oliver
    NERC Centre for Ecology and Hydrology, Oxfordshire, UK
    Ecol Lett 13:473-84. 2010
    ..We suggest that heterogeneous landscapes offer a greater range of resources and microclimates, which can buffer populations against climatic variation and generate more stable population dynamics...
  67. ncbi Color discrimination at the spatial resolution limit in a swallowtail butterfly, Papilio xuthus
    Yuichi Takeuchi
    School of Advanced Sciences, The Graduate University for Advanced Studies, Hayama 240 0193, Japan
    J Exp Biol 209:2873-9. 2006
    ..We then let the trained butterflies discriminate disks of the training color and grey disks each presented in a Y-maze apparatus...
  68. ncbi A meta-analysis of the traits affecting dispersal ability in butterflies: can wingspan be used as a proxy?
    Sandhya Sekar
    Center for Ecological Sciences, Indian Institute of Science, Bangalore 560 012, Karnataka, India
    J Anim Ecol 81:174-84. 2012
    ..It is determined by both intrinsic species traits and extrinsic landscape-related properties. 2. Using butterflies as a model system, the following questions were addressed: (i) given similar extrinsic factors, which intrinsic ..
  69. ncbi Developmental plasticity in sexual roles of butterfly species drives mutual sexual ornamentation
    Kathleen L Prudic
    Ecology and Evolutionary Biology, Yale University, 165 Prospect Street, New Haven, CT 06511, USA
    Science 331:73-5. 2011
    ..Thus, reciprocal selection through time may result in mutual sexual ornamentation...
  70. ncbi How is dispersal integrated in life histories: a quantitative analysis using butterflies
    Virginie M Stevens
    FRS FNRS, Universite de Liege, Liege, Belgium
    Ecol Lett 15:74-86. 2012
    ..with dispersal, and investigated the correlations that may constrain dispersal using published information on butterflies. Our quantitative analysis revealed that (1) dispersal directly correlated with demographic traits, mostly ..
  71. pmc Genomic sequence around butterfly wing development genes: annotation and comparative analysis
    Inês C Conceição
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    PLoS ONE 6:e23778. 2011
    ..The evolution and development of these patterns is being studied in a few target species, including Bicyclus anynana, where a whole-genome BAC library allows targeted access to large genomic regions...
  72. ncbi Generation of butterfly wing eyespot patterns: a model for morphological determination of eyespot and parafocal element
    Joji M Otaki
    The BCPH Unit of Molecular Physiology, Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903 0213, Japan
    Zoolog Sci 28:817-27. 2011
    ..Here, I examined various color patterns of nymphalid butterflies to propose the mechanics of the induction model...
  73. ncbi Reversed type of color-pattern modifications of butterfly wings: a physiological mechanism of wing-wide color-pattern determination
    Joji M Otaki
    Department of Chemistry, Biology and Marine Science, Laboratory of Cell and Functional Biology, Faculty of Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903 0213, Japan
    J Insect Physiol 53:526-37. 2007
    ..Ecdysteroid contributes to the wing-wide patterning primarily independently from CSH, but these two systems negatively interact with each other, probably in the intracellular signaling pathways...
  74. ncbi The metapopulation capacity of a fragmented landscape
    I Hanski
    Department of Ecology and Systematics, University of Helsinki, Finland
    Nature 404:755-8. 2000
    ..The metapopulation capacity should find many applications in metapopulation ecology, landscape ecology and conservation biology...
  75. ncbi Nucleotide polymorphism at a gene (Pgi) under balancing selection in a butterfly metapopulation
    Christopher W Wheat
    Department of Biological and Environmental Sciences, University of Helsinki, Finland
    Mol Biol Evol 27:267-81. 2010
    ..cinxia and the unrelated Colias eurytheme butterfly suggests a similar but not identical target of balancing selection. Our results indicate convergent evolution between these two species at both the phenotypic and molecular levels...
  76. ncbi Relative importance of density-dependent regulation and environmental stochasticity for butterfly population dynamics
    Piotr Nowicki
    Institute of Environmental Sciences, Jagiellonian University, Gronostajowa 7, Krakow, Poland
    Oecologia 161:227-39. 2009
    ..In the light of several recent studies on other butterflies that detected significant density-dependent effects, it would appear that density-dependent regulation may be ..
  77. ncbi Immunological cost of chemical defence and the evolution of herbivore diet breadth
    Angela M Smilanich
    Ecology and Evolutionary Biology, 400 Boggs, Tulane University, New Orleans, LA 70118, USA
    Ecol Lett 12:612-21. 2009
    ....
  78. ncbi Allopatric origin of cryptic butterfly species that were discovered feeding on distinct host plants in sympatry
    Carolyn S McBride
    Center for Population Biology, University of California, Davis, CA 95616, USA
    Mol Ecol 18:3639-51. 2009
    ..We discuss the implications of our results for understanding speciation among other cryptic species recently discovered in the tropics and argue that more work is needed on geographic patterns and host usage in such taxa...
  79. pmc ITS2 secondary structure improves phylogeny estimation in a radiation of blue butterflies of the subgenus Agrodiaetus (Lepidoptera: Lycaenidae: Polyommatus )
    Martin Wiemers
    Department of Animal Biodiversity, Faculty of Life Sciences, University of Vienna, Rennweg 14, 1030 Wien, Austria
    BMC Evol Biol 9:300. 2009
    ..Furthermore, we assess the use of compensatory base changes in ITS2 for the delimitation of species and discuss the prospects of ITS2 as a nuclear marker for barcoding studies...
  80. ncbi Why get big in the cold? Towards a solution to a life-history puzzle
    Isabell Karl
    Department of Animal Ecology I, Bayreuth University, P O Box 101 251, 95440 Bayreuth, Germany
    Oecologia 155:215-25. 2008
    ..Body fat and protein content increased in butterflies reared at the higher temperature, indicating favourable growth conditions...
  81. ncbi Combined EST and proteomic analysis identifies rapidly evolving seminal fluid proteins in Heliconius butterflies
    James R Walters
    Department of Ecology and Evolutionary Biology, Cornell University, USA
    Mol Biol Evol 27:2000-13. 2010
    ..the first comprehensive molecular genetic and evolutionary analysis of SFPs conducted in Lepidoptera (moths and butterflies)...
  82. ncbi A meta-analysis of dispersal in butterflies
    Virginie M Stevens
    Museum national d histoire naturelle, UMR CNRS MNHN 7179, 1 avenue du petit château, FR 91800 Brunoy, France
    Biol Rev Camb Philos Soc 85:625-42. 2010
    ..b>Butterflies have long been recognized as ideal model systems for the study of dispersal and a huge amount of data on their ..
  83. pmc Wing patterning gene redefines the mimetic history of Heliconius butterflies
    Heather M Hines
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Proc Natl Acad Sci U S A 108:19666-71. 2011
    The mimetic butterflies Heliconius erato and Heliconius melpomene have undergone parallel radiations to form a near-identical patchwork of over 20 different wing-pattern races across the Neotropics...
  84. ncbi A mosaic of chemical coevolution in a large blue butterfly
    David R Nash
    Institute of Biology, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Science 319:88-90. 2008
    ..The geographic patterns of surface chemistry indicate an ongoing coevolutionary arms race between the butterflies and Myrmica rubra, which has significant genetic differentiation between populations, but not between the ..
  85. pmc Evolutionary history of the recruitment of conserved developmental genes in association to the formation and diversification of a novel trait
    Leila T Shirai
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, P 2780 156 Oeiras, Portugal
    BMC Evol Biol 12:21. 2012
    ..Eyespots have greatly diversified under natural and sexual selection, and their formation involves genetic circuitries shared across insects...
  86. ncbi Larval food limitation in butterflies: effects on adult resource allocation and fitness
    Carol L Boggs
    Center for Conservation Biology, Department of Biological Sciences, Stanford University, Stanford, CA, 94305 5020, USA
    Oecologia 144:353-61. 2005
    ..The data, in combination with previous work, thus provide a picture of the intra-specific response of a suite of traits to ecological stress...
  87. pmc Artificially induced changes of butterfly wing colour patterns: dynamic signal interactions in eyespot development
    Joji M Otaki
    The BCPH Unit of Molecular Physiology, Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903 0213, Japan
    Sci Rep 1:111. 2011
    ..These results demonstrate limitations of the conventional gradient model and support a dynamic interactive nature of morphogenic signals for colour-pattern determination in butterfly wings...
  88. ncbi Life-history traits predict species responses to habitat area and isolation: a cross-continental synthesis
    Erik Ockinger
    Department of Ecology, Swedish University of Agricultural Sciences, P O Box 7044, 75007 Uppsala, Sweden
    Ecol Lett 13:969-79. 2010
    ..We used data from 24 independent studies of butterflies and moths from a wide range of habitats and landscapes in Europe and North America to test whether traits ..
  89. ncbi Butterfly wing pattern evolution is associated with changes in a Notch/Distal-less temporal pattern formation process
    Robert D Reed
    Department of Molecular and Cellular Biology, University of Arizona, 1007 E Lowell Street, Tucson, AZ 85721 USA
    Curr Biol 14:1159-66. 2004
    In butterflies there is a class of "intervein" wing patterns that have lines of symmetry halfway between wing veins...
  90. ncbi Physiologically induced color-pattern changes in butterfly wings: mechanistic and evolutionary implications
    Joji M Otaki
    The BCPH Unit of Molecular Physiology, Laboratory of Cell and Functional Biology, Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903 0213, Japan
    J Insect Physiol 54:1099-112. 2008
    ..Here I review physiologically induced color-pattern changes in nymphalid butterflies and their mechanistic and evolutionary implications...
  91. ncbi Evolutionary dynamics of multilocus microsatellite arrangements in the genome of the butterfly Bicyclus anynana, with implications for other Lepidoptera
    P M Brakefield
    Department of Evolutionary Biology, Institute of Biology, Leiden University, Leiden, The Netherlands
    Heredity 98:320-8. 2007
    ..A large proportion of microsatellites embedded in repetitive DNA is representative for most studied butterflies and moths, and a BLAST survey of the B...
  92. pmc Male-derived butterfly anti-aphrodisiac mediates induced indirect plant defense
    Nina E Fatouros
    Department of Plant Sciences, Laboratory of Entomology, Wageningen University, PO Box 8031, 6700 EH Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 105:10033-8. 2008
    ..Eliciting activity was present in accessory gland secretions released by mated female butterflies during egg deposition. In contrast, gland secretions from virgin female butterflies were inactive...
  93. ncbi Evolutionary dynamics of rDNA clusters on chromosomes of moths and butterflies (Lepidoptera)
    Petr Nguyen
    Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech
    Genetica 138:343-354. 2010
    ..major ribosomal DNAs (rDNAs), clustered in the nucleolar organizer regions (NORs), in 18 species of moths and butterflies using fluorescence in situ hybridization with a codling moth (Cydia pomonella) 18S rDNA probe...
  94. pmc Integrating evolutionary and functional approaches to infer adaptation at specific loci
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Evolution 64:2489-509. 2010
    ..Functional studies can provide corroborative evidence for positive selection at particular loci, and can potentially reveal specific molecular mechanisms of adaptation...
  95. ncbi Widespread mito-nuclear discordance with evidence for introgressive hybridization and selective sweeps in Lycaeides
    Zachariah Gompert
    Department of Biology, Population and Conservation Biology Program, Texas State University, San Marcos, TX 78666, USA
    Mol Ecol 17:5231-44. 2008
    ....
  96. ncbi Elements of butterfly wing patterns
    H F Nijhout
    Department of Biology, Evolution, Ecology and Organismal Biology Group, Duke University, Durham, NC 27708 0338, USA
    J Exp Zool 291:213-25. 2001
    The color patterns on the wings of butterflies are unique among animal color patterns in that the elements that make up the overall pattern are individuated...
  97. ncbi Functional genomics of life history variation in a butterfly metapopulation
    Christopher W Wheat
    Department of Biology, 208 Mueller Lab, Pennsylvania State University, University Park, PA 16802, USA
    Mol Ecol 20:1813-28. 2011
    ..Physiological studies confirmed that new-population butterflies have accelerated egg maturation, apparently regulated by higher juvenile hormone titer and angiotensin ..
  98. pmc Indole-3-acetonitrile production from indole glucosinolates deters oviposition by Pieris rapae
    Martin De Vos
    Boyce Thompson Institute for Plant Research, Ithaca, NY 14853, USA
    Plant Physiol 146:916-26. 2008
    ..rapae and perhaps other crucifer-specialist insects...
  99. ncbi Cryptic variation in butterfly eyespot development: the importance of sample size in gene expression studies
    Robert D Reed
    Department of Biology, Duke University, Durham, NC 27708, USA
    Evol Dev 9:2-9. 2007
    ....
  100. ncbi Evolutionary origins of a novel host plant detoxification gene in butterflies
    Hanna M Fischer
    Department of Entomology, Max Planck Institute for Chemical Ecology, Beutenberg Campus, Jena, Germany
    Mol Biol Evol 25:809-20. 2008
    ..Multiple domain genes are found solely within the brassicaceous-feeding Pieridae butterflies, one of them being NSP and another called major allergen (MA)...
  101. ncbi Evolutionary dynamics of host-plant specialization: a case study of the tribe Nymphalini
    N Janz
    Department of Zoology, Stockholm University, Sweden
    Evolution 55:783-96. 2001
    ..We also show that there is no directionality in host range evolution toward increased specialization, that is, specialization is not a dead end. Instead, changes in host range show a very dynamic pattern...

Research Grants28

  1. The Biodemographic Determinants of Life Span
    James R Carey; Fiscal Year: 2010
    ..of lifespan and directed by James Carey (UC Davis) will involve field studies on the medfly in Greece and butterflies in Uganda to ask questions about aging, lifespan, and impairment of insects in the wild...
  2. Biomarkers of Interoceptive Awareness in Adolescent Anorexia Nervosa
    NANCY L contact ZUCKER; Fiscal Year: 2010
    ..g. sensing the pit in your gut when you have done something wrong or the butterflies in your gut when you are worried about something)...
  3. Exploring the Venom Repertoire of Parasitoids
    JOHN HAYNES WERREN; Fiscal Year: 2013
    ..Parasitoids vary in hosts they utilize (flies, beetles, butterflies, etc), the life stage they parasitize (eggs, larvae, pupae), and whether their eggs are laid and develop within ..
  4. Circadian Clock: Differential Cryptochrome Functions
    Steven M Reppert; Fiscal Year: 2011
    ..of the unique properties of the CRY proteins by defining distinct CRY mechanisms of action in lepidopterans (butterflies and moths) using molecular, biochemical, genetic, and behavioral approaches...
  5. The Development Genetics of Butterfly Wing Patterns
    ANDREW STOEHR; Fiscal Year: 2009
    ..Third, transgenic lines of the butterflies will be generated so that ultimately, hypotheses of gene function generated from the expression assays can be ..
  6. COMPARATIVE ANALYSIS OF CLOCK GENES
    STEVEN REPPERT; Fiscal Year: 2001
    ..Increased understanding of the fundamental mechanisms of biological clock function will facilitate the development of better treatment strategies for a wide range of disorders. ..
  7. Circadian Clock: Transcriptional Control
    STEVEN REPPERT; Fiscal Year: 2008
    ..such understanding should lead to new strategies for pharmacological manipulation of the human clock to improve the treatment of jet lag and shift-work ailments, and of clock-related sleep and psychiatric disorders ..
  8. MATERNAL INFLUENCE ON DEVELOPING 24-HOUR PERIODICITY
    STEVEN REPPERT; Fiscal Year: 2002
    ..Thus, increased understanding of the basic mechanisms of biological clock function may facilitate the development of better treatment strategies for a wide range of disorders. ..
  9. CIRCADIAN CLOCK MECHANISM IN THE SCN
    STEVEN REPPERT; Fiscal Year: 2004
    ..Increased understanding of the fundamental mechanisms of biological clock function will facilitate the development of better treatment strategies for a wide range of disorders. ..
  10. LONGEVITY/CANDIDATE GENE POLYMORPHISMS IN DROSOPHILA
    Marc Tatar; Fiscal Year: 2003
    ..The genotype-phenotype associations detected with this design will be of broad significance to the problem of genetic variation for longevity in general populations. ..
  11. Self-immobilizing Proteins
    Russell Stewart; Fiscal Year: 2005
    ..The widely expected future impact of protein arrays on clinical diagnosis and other areas of human health care may be realized more quickly with new and effective protein modification technology. ..
  12. MicroRNA evolution and species divergence in Drosophila
    Chung I Wu; Fiscal Year: 2010
    ..A survey of the scope of microRNA repertoire and their rise and fall through evolution will be useful for understanding their roles in regulating the normal and aberrant phenotypes in human populations. ..
  13. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  14. Transcriptional and genic basis of incipient speciation
    Chung I Wu; Fiscal Year: 2008
    ..We expect to identify a number of candidate "speciation genes,* and will carry out precise gene replacement (Rong and Golic 2000; Greenberg et al. 2003) to confirm their effects on the mating behavior. ..
  15. STEROL METABOLISM & DIETARY CHOLESTEROL IN SLO SYNDROME
    WILLIAM CONNOR; Fiscal Year: 2002
    ..Developmental testing will be performed. ..
  16. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  17. Dynamically Crosslinked Hydrogels
    Russell Stewart; Fiscal Year: 2006
    ..These novel hydrogels may find wide ranging biomedical applications in drug delivery, as active surface coatings or microactuators in medical devices. ..
  18. Genetics of Reproductive Senescence
    Marc Tatar; Fiscal Year: 2010
    ..Coupled with the program-wide multidimensional measures of somatic aging, we shall evaluate the extent that reproductive and somatic aging are concordant or independent. ..
  19. PHARMACOLOGY OF MOSSY FIBER SYNAPTIC PLASTICITY
    Daniel Johnston; Fiscal Year: 2008
    ..abstract_text> ..
  20. Modulation of Dendritic K+ Channels in Hippocampus
    Daniel Johnston; Fiscal Year: 2004
    ..The results of these experiments will provide basic information important for studies of temporal lobe epilepsy, Alzheimer's disease, schizophrenia, and depression. ..
  21. Regulatory systems of Drosophila aging
    Marc Tatar; Fiscal Year: 2007
    ..In a comprehensive experimental design, we shall assess qualifies of stress resistance, central metabolism and mitochondria function to determine which feature best predicts variance in life span [unreadable] [unreadable]..
  22. Molecular Target Focused Discovery of Anticancer Drugs
    George R Pettit; Fiscal Year: 2010
    ....
  23. Functions and Interactions dFOXO in Drosopila Aging
    Marc Tatar; Fiscal Year: 2010
    ....
  24. Genetic Basis of Posterior Lobe Evolution in Drosophila
    Barry Williams; Fiscal Year: 2005
    ..Finally, I will use population genetic methods to identify specific regions in the protein coding and regulatory sequences that have evolved under positive selection. ..
  25. Molecular Target Focused Discovery of Anticancer Drugs
    GEORGE PETTIT; Fiscal Year: 2007
    ..In summary, the proposed research will be sharply aimed at the discovery and very rapid development of new anticancer drugs for the NCI programs direct at improving human cancer treatments. ..
  26. REGULATION OF NEURONAL EXCITABILITY
    Daniel Johnston; Fiscal Year: 2008
    ....
  27. USING DISEQUILIBRIUM MAPPING TO DISSECT COMPLEX TRAITS
    Anthony Long; Fiscal Year: 2003
    ..The set of candidate causative polymorphism will allow the above hypotheses to be directly addressed. ..