anopheles

Summary

Summary: A genus of mosquitoes (CULICIDAE) that are known vectors of MALARIA.

Top Publications

  1. ncbi Pyrethroid resistance in African anopheline mosquitoes: what are the implications for malaria control?
    Hilary Ranson
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA
    Trends Parasitol 27:91-8. 2011
  2. ncbi Changes in Anopheles funestus biting behavior following universal coverage of long-lasting insecticidal nets in Benin
    Nicolas Moiroux
    MIVEGEC IRD 224 CNRS 5290 UM1 UM2, Institut de Recherche pour le Developpement, Montpellier, France
    J Infect Dis 206:1622-9. 2012
  3. pmc Increased proportions of outdoor feeding among residual malaria vector populations following increased use of insecticide-treated nets in rural Tanzania
    Tanya L Russell
    Ifakara Health Institute, Biomedical and Environmental Thematic Group, Ifakara, Tanzania
    Malar J 10:80. 2011
  4. pmc A research agenda to underpin malaria eradication
    Pedro L Alonso
    Barcelona Centre for International Health Research Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
    PLoS Med 8:e1000406. 2011
  5. pmc A global map of dominant malaria vectors
    Marianne E Sinka
    Spatial Ecology and Epidemiology Group, Tinbergen Building, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Parasit Vectors 5:69. 2012
  6. ncbi Wolbachia invades Anopheles stephensi populations and induces refractoriness to Plasmodium infection
    Guowu Bian
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA
    Science 340:748-51. 2013
  7. pmc Species shifts in the Anopheles gambiae complex: do LLINs successfully control Anopheles arabiensis?
    Jovin Kitau
    Kilimanjaro Christian Medical College, Tumaini University, Moshi, Tanzania
    PLoS ONE 7:e31481. 2012
  8. pmc The dominant Anopheles vectors of human malaria in the Asia-Pacific region: occurrence data, distribution maps and bionomic précis
    Marianne E Sinka
    Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, UK
    Parasit Vectors 4:89. 2011
  9. ncbi A climate-based distribution model of malaria transmission in sub-Saharan Africa
    M H Craig
    National Malaria Research Programme, South African Medical Research Council, PO Box 17120, Congella, Durban 4013, South Africa
    Parasitol Today 15:105-11. 1999
  10. ncbi Early biting rhythm in the Afro-tropical vector of malaria, Anopheles arabiensis, and challenges for its control in Ethiopia
    M Yohannes
    Department of Microbiology, Immunology and Parasitology, College of Health Science, Mekelle University, Tigray, Ethiopia
    Med Vet Entomol 26:103-5. 2012

Detail Information

Publications330 found, 100 shown here

  1. ncbi Pyrethroid resistance in African anopheline mosquitoes: what are the implications for malaria control?
    Hilary Ranson
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA
    Trends Parasitol 27:91-8. 2011
    ..As we move into the malaria eradication era, it is vital that the implications of insecticide resistance are understood and strategies to mitigate these effects are implemented...
  2. ncbi Changes in Anopheles funestus biting behavior following universal coverage of long-lasting insecticidal nets in Benin
    Nicolas Moiroux
    MIVEGEC IRD 224 CNRS 5290 UM1 UM2, Institut de Recherche pour le Developpement, Montpellier, France
    J Infect Dis 206:1622-9. 2012
    ..We investigated whether full coverage of long-lasting insecticide-treated mosquito nets (LLINs) may induce a switch in biting behavior in Anopheles funestus, a major malaria vector in Africa.
  3. pmc Increased proportions of outdoor feeding among residual malaria vector populations following increased use of insecticide-treated nets in rural Tanzania
    Tanya L Russell
    Ifakara Health Institute, Biomedical and Environmental Thematic Group, Ifakara, Tanzania
    Malar J 10:80. 2011
    ..In the surveyed area of rural southern Tanzania, bed net use steadily increased over the last decade, reducing malaria transmission intensity by 94%...
  4. pmc A research agenda to underpin malaria eradication
    Pedro L Alonso
    Barcelona Centre for International Health Research Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
    PLoS Med 8:e1000406. 2011
    ....
  5. pmc A global map of dominant malaria vectors
    Marianne E Sinka
    Spatial Ecology and Epidemiology Group, Tinbergen Building, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Parasit Vectors 5:69. 2012
    ..Global maps, in particular those based on vector distributions, have long been used to help visualise the global extent of malaria. Few, however, have been created with the support of a comprehensive and extensive evidence-based approach...
  6. ncbi Wolbachia invades Anopheles stephensi populations and induces refractoriness to Plasmodium infection
    Guowu Bian
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA
    Science 340:748-51. 2013
    ..Here, we report the establishment of a stable Wolbachia infection in an important malaria vector, Anopheles stephensi. In A...
  7. pmc Species shifts in the Anopheles gambiae complex: do LLINs successfully control Anopheles arabiensis?
    Jovin Kitau
    Kilimanjaro Christian Medical College, Tumaini University, Moshi, Tanzania
    PLoS ONE 7:e31481. 2012
    ..Shifts in malaria vector species ratio have coincided with the scale-up suggesting that some species are being controlled by ITNs/LLINs better than others...
  8. pmc The dominant Anopheles vectors of human malaria in the Asia-Pacific region: occurrence data, distribution maps and bionomic précis
    Marianne E Sinka
    Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, UK
    Parasit Vectors 4:89. 2011
    ....
  9. ncbi A climate-based distribution model of malaria transmission in sub-Saharan Africa
    M H Craig
    National Malaria Research Programme, South African Medical Research Council, PO Box 17120, Congella, Durban 4013, South Africa
    Parasitol Today 15:105-11. 1999
    ..Together with population, morbidity and mortality data, the model provides a fundamental tool for strategic control of malaria...
  10. ncbi Early biting rhythm in the Afro-tropical vector of malaria, Anopheles arabiensis, and challenges for its control in Ethiopia
    M Yohannes
    Department of Microbiology, Immunology and Parasitology, College of Health Science, Mekelle University, Tigray, Ethiopia
    Med Vet Entomol 26:103-5. 2012
    The biting cycle of the malaria vector Anopheles arabiensis Patton (Diptera: Culicidae) was assessed by hourly light trap collections in three villages in Tigray, northern Ethiopia...
  11. ncbi The molecular basis of insecticide resistance in mosquitoes
    Janet Hemingway
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Insect Biochem Mol Biol 34:653-65. 2004
    ..these changes are only now being fully determined, aided by the availability of the Drosophila melanogaster and Anopheles gambiae genome sequences...
  12. pmc Malaria in Brazil: an overview
    Joseli Oliveira-Ferreira
    Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz, FIOCRUZ, Pavilhão Leônidas Deane 5 degrees andar, Av Brasil 4365, Manguinhos, Rio de Janeiro, RJ CEP 21 045 900, RJ Brazil
    Malar J 9:115. 2010
    ..Although the main mosquito vector (Anopheles darlingi) is present in about 80% of the country, currently the incidence of malaria in Brazil is almost ..
  13. ncbi G protein-coupled receptors in Anopheles gambiae
    Catherine A Hill
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Science 298:176-8. 2002
    We used bioinformatic approaches to identify a total of 276 G protein-coupled receptors (GPCRs) from the Anopheles gambiae genome...
  14. ncbi Odor-mediated behavior of Afrotropical malaria mosquitoes
    W Takken
    Laboratory of Entomology, Wageningen Agricultural University, The Netherlands
    Annu Rev Entomol 44:131-57. 1999
    The African mosquito species Anopheles gambiae sensu lato s.l. and Anopheles funestus rank among the world's most efficient vectors of human malaria...
  15. ncbi Simultaneous identification of species and molecular forms of the Anopheles gambiae complex by PCR-RFLP
    C Fanello
    London School of Hygiene and Tropical Medicine, London, UK
    Med Vet Entomol 16:461-4. 2002
    For differential identification of sibling species in the Anopheles gambiae Giles complex (Diptera: Culicidae), including simultaneous separation of M and S molecular forms within An...
  16. ncbi Evolution of supergene families associated with insecticide resistance
    Hilary Ranson
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Science 298:179-81. 2002
    ..We have searched the Anopheles gambiae genome for members of the three major enzyme families- the carboxylesterases, glutathione transferases, ..
  17. pmc Biologically meaningful coverage indicators for eliminating malaria transmission
    Samson S Kiware
    Biomedical and Environmental Thematic Group, Ifakara Health Institute, PO Box 53, Ifakara, Tanzania
    Biol Lett 8:874-7. 2012
    ....
  18. pmc Anopheles Imd pathway factors and effectors in infection intensity-dependent anti-Plasmodium action
    Lindsey S Garver
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Pathog 8:e1002737. 2012
    The Anopheles gambiae immune response against Plasmodium falciparum, an etiological agent of human malaria, has been identified as a source of potential anti-Plasmodium genes and mechanisms to be exploited in efforts to control the ..
  19. pmc Additional selection for insecticide resistance in urban malaria vectors: DDT resistance in Anopheles arabiensis from Bobo-Dioulasso, Burkina Faso
    Christopher M Jones
    Vector Group, Liverpool School of Tropical Medicine, Liverpool, Merseyside, United Kingdom
    PLoS ONE 7:e45995. 2012
    In the city of Bobo-Dioulasso in Burkina Faso, Anopheles arabiensis has superseded Anopheles gambiae s.s...
  20. pmc Warmer temperatures reduce the vectorial capacity of malaria mosquitoes
    Krijn P Paaijmans
    Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA 16802, USA
    Biol Lett 8:465-8. 2012
    ..These results highlight the need to understand the interactive effects of environmental temperature on multiple host-disease life-history traits and challenge the assumptions of many current disease models that ignore this complexity...
  21. ncbi The unique mutation in ace-1 giving high insecticide resistance is easily detectable in mosquito vectors
    M Weill
    Institut des Sciences de l Evolution UMR 5554, Laboratoire Genetique et Environnement, Universite Montpellier II, Montpellier, France
    Insect Mol Biol 13:1-7. 2004
    ..A single mutation (G119S of the ace-1 gene) explains this high resistance in Culex pipiens and in Anopheles gambiae...
  22. pmc De novo transcriptome sequencing in Anopheles funestus using Illumina RNA-seq technology
    Jacob E Crawford
    Department of Entomology, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 5:e14202. 2010
    b>Anopheles funestus is one of the primary vectors of human malaria, which causes a million deaths each year in sub-Saharan Africa...
  23. pmc Modeling the effects of weather and climate change on malaria transmission
    Paul Edward Parham
    Department of Infectious Disease Epidemiology, Grantham Institute for Climate Change, Imperial College London, London, United Kingdom
    Environ Health Perspect 118:620-6. 2010
    ....
  24. pmc Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major malaria vector
    Charles S Wondji
    Liverpool School of Tropical Medicine, Liverpool, L3 5QA, United Kingdom
    Genome Res 19:452-9. 2009
    Pyrethroid resistance in Anopheles funestus is a potential obstacle to malaria control in Africa. Tools are needed to detect resistance in field populations...
  25. pmc Impact of promoting longer-lasting insecticide treatment of bed nets upon malaria transmission in a rural Tanzanian setting with pre-existing high coverage of untreated nets
    Tanya L Russell
    Biomedical and Environmental Thematic Group, Ifakara Health Institute, P O Box 53, Ifakara, Tanzania
    Malar J 9:187. 2010
    ..Since 2006, a national-scale programme has promoted the use of longer-lasting insecticide treatment kits (consisting of an insecticide plus binder) co-packaged with all bed nets manufactured in the country...
  26. ncbi Variation in malaria transmission intensity in seven sites throughout Uganda
    Paul Edward Okello
    Epidemiological Surveillance Division, Ministry of Health, Kampala, Uganda
    Am J Trop Med Hyg 75:219-25. 2006
    ..b>Anopheles gambiae sensu stricto was the main vector in five of the seven study sites, and An...
  27. pmc Exploring mechanisms of multiple insecticide resistance in a population of the malaria vector Anopheles funestus in Benin
    Rousseau Djouaka
    International Institute of Tropical Agriculture, Cotonou, Benin
    PLoS ONE 6:e27760. 2011
    The insecticide resistance status of the malaria vector Anopheles funestus and the underlying resistance mechanisms remain uncharacterised in many parts of Africa, notably in Benin, West Africa...
  28. ncbi Spatial and temporal heterogeneity of Anopheles mosquitoes and Plasmodium falciparum transmission along the Kenyan coast
    Charles M Mbogo
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Am J Trop Med Hyg 68:734-42. 2003
    The seasonal dynamics and spatial distributions of Anopheles mosquitoes and Plasmodium falciparum parasites were studied for one year at 30 villages in Malindi, Kilifi, and Kwale Districts along the coast of Kenya...
  29. ncbi Molecular systematics and insecticide resistance in the major African malaria vector Anopheles funestus
    Maureen Coetzee
    Malaria Entomology Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2000, South Africa
    Annu Rev Entomol 58:393-412. 2013
    b>Anopheles funestus is one of three major African vectors of malaria. Its distribution extends over much of the tropics and subtropics wherever suitable swampy breeding habitats are present...
  30. ncbi Molecular evidence of incipient speciation within Anopheles gambiae s.s. in West Africa
    A Della Torre
    Istituto di Parassitologia, Fondazione Pasteur Cenci Bolognetti, Universita di Roma La Sapienza, Piazzale Aldo Moro 5, 00185, Rome, Italy
    Insect Mol Biol 10:9-18. 2001
    ..and identified by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis Anopheles gambiae s.s. samples collected in several African countries...
  31. pmc Integrated malaria vector control with microbial larvicides and insecticide-treated nets in western Kenya: a controlled trial
    Ulrike Fillinger
    Disease Control and Vector Biology Unit, London School of Hygiene and Tropical Medicine, London, England
    Bull World Health Organ 87:655-65. 2009
    ....
  32. ncbi The effect of deforestation on the human-biting rate of Anopheles darlingi, the primary vector of Falciparum malaria in the Peruvian Amazon
    Amy Yomiko Vittor
    School of Medicine, Stanford University, Stanford, California, USA
    Am J Trop Med Hyg 74:3-11. 2006
    ..on malaria, we conducted a year-long study of the rates at which the primary malaria vector in the Amazon, Anopheles darlingi, fed on humans in areas with varying degrees of ecological alteration in the Peruvian Amazon...
  33. pmc Malaria in the Greater Mekong Subregion: heterogeneity and complexity
    Liwang Cui
    Department of Entomology, The Pennsylvania State University, University Park, 16801, USA
    Acta Trop 121:227-39. 2012
    ....
  34. ncbi The role of agricultural use of insecticides in resistance to pyrethroids in Anopheles gambiae s.l. in Burkina Faso
    Abdoulaye Diabate
    Laboratoire d Entomologie et de Parasitologie, Centre Muraz, Bobo Dioulasso, Burkina Faso
    Am J Trop Med Hyg 67:617-22. 2002
    ..b>Anopheles gambiae s.l...
  35. ncbi A cocktail polymerase chain reaction assay to identify members of the Anopheles funestus (Diptera: Culicidae) group
    L L Koekemoer
    Department of Clinical Microbiology and Infectious Diseases, School of Pathology of the National Health Laboratory Services and the University of the Witwatersrand, Johannesburg, South Africa
    Am J Trop Med Hyg 66:804-11. 2002
    b>Anopheles funestus Giles is a major malaria vector in Africa belonging to a group of species with morphologically similar characteristics. Morphological identification of members of the A...
  36. pmc Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus
    Jacob M Riveron
    Vector Biology Department, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom
    Proc Natl Acad Sci U S A 110:252-7. 2013
    ..However, resistance to this insecticide class in the malaria vector Anopheles funestus is spreading rapidly across Africa, threatening the success of ongoing and future malaria control ..
  37. ncbi The genome sequence of the malaria mosquito Anopheles gambiae
    Robert A Holt
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 298:129-49. 2002
    b>Anopheles gambiae is the principal vector of malaria, a disease that afflicts more than 500 million people and causes more than 1 million deaths each year. Tenfold shotgun sequence coverage was obtained from the PEST strain of A...
  38. pmc Mosquito feeding assays to determine the infectiousness of naturally infected Plasmodium falciparum gametocyte carriers
    Teun Bousema
    Department of Immunity and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 7:e42821. 2012
    ..Such interventions require assays that reliably measure the transmission of Plasmodium from humans to Anopheles mosquitoes.
  39. pmc The importance of considering community-level effects when selecting insecticidal malaria vector products
    Gerry F Killeen
    Ifakara Health Institute, Biomedical and Environmental Thematic Group, PO Box 53, Ifakara, Morogoro, United Republic of Tanzania
    Parasit Vectors 4:160. 2011
    ..However, at high coverage, community-level reductions of mosquito density and survival prevent more transmission exposure than the personal protection acquired by using a net or living in a sprayed house...
  40. ncbi Pyrethroid tolerance is associated with elevated expression of antioxidants and agricultural practice in Anopheles arabiensis sampled from an area of cotton fields in Northern Cameroon
    Pie Müller
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Mol Ecol 17:1145-55. 2008
    ..The tolerance of the malaria vector, Anopheles arabiensis to deltamethrin was determined in a field population from a cotton-growing region of Northern ..
  41. pmc Lethal and pre-lethal effects of a fungal biopesticide contribute to substantial and rapid control of malaria vectors
    Simon Blanford
    Center for Infectious Disease Dynamics, Mueller Laboratory, Department of Biology, Penn State University, University Park, Pennsylvania, United States of America
    PLoS ONE 6:e23591. 2011
    ..These results support broadening the current vector control paradigm beyond fast-acting chemical toxins...
  42. pmc Engineered anopheles immunity to Plasmodium infection
    Yuemei Dong
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Pathog 7:e1002458. 2011
    A causative agent of human malaria, Plasmodium falciparum, is transmitted by Anopheles mosquitoes. The malaria parasite is under intensive attack from the mosquito's innate immune system during its sporogonic development...
  43. pmc Development of a new version of the Liverpool Malaria Model. I. Refining the parameter settings and mathematical formulation of basic processes based on a literature review
    Volker Ermert
    Institute of Geophysics and Meteorology, University of Cologne, Cologne, Germany
    Malar J 10:35. 2011
    ..In this study, the parameter settings of the LMM are refined and a new mathematical formulation of key processes related to the growth and size of the vector population are developed...
  44. ncbi A global index representing the stability of malaria transmission
    Anthony Kiszewski
    Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Trop Med Hyg 70:486-98. 2004
    ....
  45. ncbi Identification of bacterial microflora in the midgut of the larvae and adult of wild caught Anopheles stephensi: a step toward finding suitable paratransgenesis candidates
    Ali Reza Chavshin
    Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Iran
    Acta Trop 121:129-34. 2012
    ..Anopheline mosquitoes refractory to transmission of malaria, the microbiota of wild larvae and adult Anopheles stephensi mosquito midgut from southern Iran was studied using a conventional cell-free culture technique and ..
  46. pmc Relationship between knockdown resistance, metabolic detoxification and organismal resistance to pyrethroids in Anopheles sinensis
    Daibin Zhong
    Program in Public Health, College of Health Sciences, University of California Irvine, Irvine, CA, USA
    PLoS ONE 8:e55475. 2013
    b>Anopheles sinensis is the most important vector of malaria in Southeast Asia, including China...
  47. ncbi Safety of pyrethroid-treated mosquito nets
    M Zaim
    World Health Organization Pesticides Evaluation Scheme, Strategy Development and Monitoring of Parasitic Diseases and Vector Control, Communicable Diseases Control Prevention and Eradication World Health Organization, Geneva, Switzerland
    Med Vet Entomol 14:1-5. 2000
    The use of insecticide treated nets (ITNs) for personal protection against malaria vector Anopheles mosquitoes (Diptera: Culicidae) has become popular during the past decade...
  48. pmc Transcriptome of the adult female malaria mosquito vector Anopheles albimanus
    Jesus Martinez-Barnetche
    Centro De Investigacion sobre Enfermedades Infecciosas, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    BMC Genomics 13:207. 2012
    Human Malaria is transmitted by mosquitoes of the genus Anopheles. Transmission is a complex phenomenon involving biological and environmental factors of humans, parasites and mosquitoes...
  49. pmc Mathematical evaluation of community level impact of combining bed nets and indoor residual spraying upon malaria transmission in areas where the main vectors are Anopheles arabiensis mosquitoes
    Fredros O Okumu
    Environmental Health and Ecological Sciences Thematic Group, Ifakara Health Institute, Ifakara, Tanzania
    Parasit Vectors 6:17. 2013
    ....
  50. ncbi Impact of permethrin-treated bed nets on entomologic indices in an area of intense year-round malaria transmission
    John E Gimnig
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:16-22. 2003
    ..Indoor resting densities of fed Anopheles gambiae s.l. and An. funestus in intervention houses were 58.5% (P = 0.010) and 94.5% (P = 0...
  51. pmc First evidence of high knockdown resistance frequency in Anopheles arabiensis (Diptera: Culicidae) from Ethiopia
    Delenasaw Yewhalaw
    Department of Biology, Jimma University, Jimma, Ethiopia
    Am J Trop Med Hyg 83:122-5. 2010
    The status of knockdown resistance (kdr) mutation was investigated in the major malaria vector Anopheles arabiensis Patton (Diptera: Culicidae) from Ethiopia...
  52. pmc Linking deforestation to malaria in the Amazon: characterization of the breeding habitat of the principal malaria vector, Anopheles darlingi
    Amy Y Vittor
    Department of Internal Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Trop Med Hyg 81:5-12. 2009
    This study examined the larval breeding habitat of a major South American malaria vector, Anopheles darlingi, in areas with varying degrees of ecologic alteration in the Peruvian Amazon...
  53. ncbi Does kdr genotype predict insecticide-resistance phenotype in mosquitoes?
    Martin J Donnelly
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L35QA, UK
    Trends Parasitol 25:213-9. 2009
    ..However, we emphasize that kdr genotype might explain only a portion of heritable variation in resistance and that diagnostic assays to test the importance of other resistance mechanisms in field populations are required...
  54. pmc Serologic markers for detecting malaria in areas of low endemicity, Somalia, 2008
    Teun Bousema
    London School of Hygiene and Tropical Medicine, London, UK
    Emerg Infect Dis 16:392-9. 2010
    ..016). Serologic markers are a promising tool for detecting spatial variation in malaria exposure and evaluating malaria control efforts in areas where transmission has decreased to levels below the detection limit of microscopy...
  55. pmc Multimodal pyrethroid resistance in malaria vectors, Anopheles gambiae s.s., Anopheles arabiensis, and Anopheles funestus s.s. in western Kenya
    Hitoshi Kawada
    Department of Vector Ecology and Environment, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    PLoS ONE 6:e22574. 2011
    b>Anopheles gambiae s.s., Anopheles arabiensis, and Anopheles funestus s.s. are the most important species for malaria transmission...
  56. pmc Is the current decline in malaria burden in sub-Saharan Africa due to a decrease in vector population?
    Dan W Meyrowitsch
    Section of Health Services Research, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5B, DK 1014, Copenhagen K, Denmark
    Malar J 10:188. 2011
    ..However, the decline has also occurred in areas with limited or no intervention. The present study assessed temporal changes in Anopheline populations in two highly malaria-endemic communities of NE Tanzania during the period 1998-2009...
  57. ncbi Identification of a distinct family of genes encoding atypical odorant-binding proteins in the malaria vector mosquito, Anopheles gambiae
    P X Xu
    Department of Pharmacology, Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Insect Mol Biol 12:549-60. 2003
    We performed a genome-wide analysis for candidate odorant-binding protein (OBP) genes in the malaria vector Anopheles gambiae (Ag)...
  58. pmc Reconsideration of Anopheles rivulorum as a vector of Plasmodium falciparum in western Kenya: some evidence from biting time, blood preference, sporozoite positive rate, and pyrethroid resistance
    Hitoshi Kawada
    Department of Vector Ecology and Environment, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    Parasit Vectors 5:230. 2012
    b>Anopheles gambiae, An. arabiensis, and An. funestus are widespread malaria vectors in Africa. Anopheles rivulorum is the next most widespread species in the An. funestus group. The role of An...
  59. ncbi An inexpensive and effective larval diet for Anopheles arabiensis (Diptera: Culicidae): eat like a horse, a bird, or a fish?
    D Damiens
    Insect Pest Control Laboratory, Joint FAO IAEA Division of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency, Wagramerstrasse 5, P O Box 100, A 1400 Vienna, Austria
    J Med Entomol 49:1001-11. 2012
    ..Specifically, to control Anopheles arabiensis Patton (Diptera: Culicidae) in a pilot area in northern Sudan, 1 million An...
  60. pmc Evidence of increasing Leu-Phe knockdown resistance mutation in Anopheles gambiae from Niger following a nationwide long-lasting insecticide-treated nets implementation
    Cyrille Czeher
    Parasitology Unit, centre de recherche médicale et sanitaire, Institut Pasteur International Network, Niamey, Niger
    Malar J 7:189. 2008
    ..The distribution of the kdr-west (kdr-w) Leu-Phe mutation was studied in Anopheles gambiae s.l...
  61. ncbi The impact of a small-scale irrigation scheme on malaria transmission in Ziway area, Central Ethiopia
    Solomon Kibret
    Department of Biology, Addis Ababa University, Addis Ababa, Ethiopia
    Trop Med Int Health 15:41-50. 2010
    ..To assess the impact of a small-scale irrigation scheme in Ziway area, a semi-arid area in the Central Ethiopian Rift Valley, on malaria transmission...
  62. pmc Multiple insecticide resistance: an impediment to insecticide-based malaria vector control program
    Delenasaw Yewhalaw
    Department of Biology, Jimma University, Jimma, Ethiopia
    PLoS ONE 6:e16066. 2011
    ..We assessed the susceptibility levels of Anopheles arabiensis to insecticides used in malaria control, characterized basic mechanisms underlying resistance, and ..
  63. pmc DNA barcoding reveals both known and novel taxa in the Albitarsis Group (Anopheles: Nyssorhynchus) of Neotropical malaria vectors
    Freddy Ruiz-López
    Entomology Branch, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, USA
    Parasit Vectors 5:44. 2012
    Mosquitoes belonging to the Albitarsis Group (Anopheles: Nyssorhynchus) are of importance as malaria vectors across the Neotropics...
  64. ncbi Microsatellite DNA polymorphism and heterozygosity among field and laboratory populations of Anopheles gambiae ss (Diptera: Culicidae)
    D E Norris
    The Johns Hopkins University, School of Hygiene and Public Health, The W Harry Feinstone Department of Molecular Microbiology and Immunology, Baltimore, MD 21205, USA
    J Med Entomol 38:336-40. 2001
    ..microsatellite polymorphism at nine loci located on chromosome 3 among two colonies and a field population of Anopheles gambiae sensu stricto Giles mosquitoes...
  65. pmc Vector capacity of Anopheles sinensis in malaria outbreak areas of central China
    Jia Yun Pan
    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, People s Republic of China
    Parasit Vectors 5:136. 2012
    ..In order to understand the role of the vector in the transmission of malaria during the outbreak period, the vector capacity of An. sinensis in Huanghuai valley of central China was investigated...
  66. pmc Detoxification enzymes associated with insecticide resistance in laboratory strains of Anopheles arabiensis of different geographic origin
    Luisa Nardini
    Vector Control Reference Unit, Centre for Opportunistic, Tropical and Hospital Infections, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa
    Parasit Vectors 5:113. 2012
    ..b>Anopheles arabiensis is one of the main African malaria vectors and insecticide resistance in this species has been ..
  67. ncbi Do insecticide-treated bednets have an effect on malaria vectors?
    Willem Takken
    Laboratory of Entomology, Wageningen University, Wageningen, The Netherlands
    Trop Med Int Health 7:1022-30. 2002
    ..Examples are presented in which untreated nets provided a reasonable degree of protection against malaria...
  68. pmc Local adaptation and vector-mediated population structure in Plasmodium vivax malaria
    Deirdre A Joy
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Mol Biol Evol 25:1245-52. 2008
    Plasmodium vivax in southern Mexico exhibits different infectivities to 2 local mosquito vectors, Anopheles pseudopunctipennis and Anopheles albimanus...
  69. pmc Human antibody responses to the Anopheles salivary gSG6-P1 peptide: a novel tool for evaluating the efficacy of ITNs in malaria vector control
    Papa Makhtar Drame
    UR016 Contrôle et Caractérisation des Populations de Vecteurs, Institut de Recherche pour le Developpement, Cotonou, Benin
    PLoS ONE 5:e15596. 2010
    ..The gSG6-P1 peptide from gSG6 protein of Anopheles gambiae salivary glands was previously designed as a specific salivary sequence of malaria vector species...
  70. pmc Pyrethroid resistance in an Anopheles funestus population from Uganda
    John C Morgan
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS ONE 5:e11872. 2010
    The susceptibility status of Anopheles funestus to insecticides remains largely unknown in most parts of Africa because of the difficulty in rearing field-caught mosquitoes of this malaria vector...
  71. pmc Spatial and temporal variation in the kdr allele L1014S in Anopheles gambiae s.s. and phenotypic variability in susceptibility to insecticides in Western Kenya
    Derrick K Mathias
    Centre for Global Health Research, Kenya Medical Research Institute, PO Box 1578, Kisumu, Kenya
    Malar J 10:10. 2011
    ..This study investigated the extent of insecticide resistance in Anopheles gambiae s.l., Anopheles gambiae s.s...
  72. ncbi Characteristics of larval anopheline (Diptera: Culicidae) habitats in Western Kenya
    J E Gimnig
    Kenya Medical Research Institute, Centre for Vector Biology and Control Research, Kisumu
    J Med Entomol 38:282-8. 2001
    ..In total, 1,751 Anopheles gambiae s.l. and 2,784 Anopheles funestus Giles were identified. Identification of An. gambiae s.l...
  73. ncbi Effect of temperature on the development of the aquatic stages of Anopheles gambiae sensu stricto (Diptera: Culicidae)
    M N Bayoh
    School of Biological and Biomedical Sciences Science Laboratories, University of Durham Durham DH1 3LE UK
    Bull Entomol Res 93:375-81. 2003
    ..Here the development of the aquatic stages of Africa's principal malaria vector, Anopheles gambiae s.s. Giles, is described at different temperatures...
  74. pmc The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host
    Alida Coppi
    Department of Medical Parasitology, New York University School of Medicine, New York, NY 10010, USA
    J Exp Med 208:341-56. 2011
    ..These data provide structure-function information relevant to malaria vaccine development...
  75. pmc Comparative susceptibility to Plasmodium falciparum of the molecular forms M and S of Anopheles gambiae and Anopheles arabiensis
    Mamadou O Ndiath
    Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes URMITE, IRD, BP 1386 Dakar, Senegal
    Malar J 10:269. 2011
    The different taxa belonging to Anopheles gambiae complex display phenotypic differences that may impact their contribution to malaria transmission...
  76. ncbi First attempt to validate the gSG6-P1 salivary peptide as an immuno-epidemiological tool for evaluating human exposure to Anopheles funestus bites
    Anne Poinsignon
    Unité Caractérisation et Contrôle des Populations de Vecteurs, Institut de Recherche pour le Developpement, Montpellier, France
    Trop Med Int Health 15:1198-203. 2010
    The development of a biomarker of exposure based on the evaluation of the human antibody response specific to Anopheles salivary proteins seems promising in improving malaria control...
  77. pmc piggyBac transposon remobilization and enhancer detection in Anopheles mosquitoes
    DAVID A O'BROCHTA
    Department of Entomology and Institute for Bioscience and Biotechnology Research, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 108:16339-44. 2011
    ..We show that the piggyBac transposon is highly active in the germline of the human malaria vector Anopheles stephensi. Up to 6% of the progeny from transgenic A...
  78. pmc Human exposure to anopheline mosquitoes occurs primarily indoors, even for users of insecticide-treated nets in Luangwa Valley, South-east Zambia
    Aklilu Seyoum
    Liverpool School of Tropical Medicine, Vector Group, Pembroke Place, Liverpool L3 5QA, UK
    Parasit Vectors 5:101. 2012
    ..We studied the human biting behaviour of the malaria vector Anopheles funestus Giles and the potential malaria vector Anopheles quadriannulatus Theobald in Luangwa valley, south-east ..
  79. ncbi Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium
    Malou Fraiture
    UPR 9022 CNRS, AVENIR group Inserm, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, 67084 Strasbourg, France
    Cell Host Microbe 5:273-84. 2009
    Plasmodium development within Anopheles mosquitoes is a vulnerable step in the parasite transmission cycle, and targeting this step represents a promising strategy for malaria control...
  80. pmc Genetic evidence for malaria vectors of the Anopheles sundaicus complex in Sri Lanka with morphological characteristics attributed to Anopheles subpictus species B
    Sinnathamby N Surendran
    Department of Zoology, Faculty of Science, University of Jaffna, Jaffna, Sri Lanka
    Malar J 9:343. 2010
    b>Anopheles subpictus sensu lato, a widespread malaria vector in Asia, is reportedly composed of four sibling species A - D...
  81. pmc A simulation model of African Anopheles ecology and population dynamics for the analysis of malaria transmission
    Jean Marc O Depinay
    Fogarty International Center, National Institutes of Health, 16 Center Drive, Bethesda MD 20892, USA
    Malar J 3:29. 2004
    ..However, malaria remains uncontrolled and is increasing in many areas, as are vector and parasite resistance to insecticides and drugs...
  82. pmc Efficiency of salivary gland invasion by malaria sporozoites is controlled by rapid sporozoite destruction in the mosquito haemocoel
    JULIAN F HILLYER
    Center for Microbial and Plant Genomics and Department of Microbiology, University of Minnesota, 1500 Gortner Ave, Saint Paul, MN 55108, USA
    Int J Parasitol 37:673-81. 2007
    ..Only 2% of Anopheles gambiae haemocytes phagocytized Plasmodium berghei sporozoites, a rate insufficient to explain the extent of ..
  83. pmc Substantial contribution of submicroscopical Plasmodium falciparum gametocyte carriage to the infectious reservoir in an area of seasonal transmission
    André Lin Ouédraogo
    Department of Biomedical Sciences, Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
    PLoS ONE 4:e8410. 2009
    ..Gametocyte densities below the microscopical threshold of detection may be sufficient to infect mosquitoes but the importance of submicroscopical gametocyte carriage in different transmission settings is unknown...
  84. ncbi A hemocyte-like cell line established from the malaria vector Anopheles gambiae expresses six prophenoloxidase genes
    H M Muller
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    J Biol Chem 274:11727-35. 1999
    Cell lines from the malaria vector Anopheles gambiae have been established as a tool for the study of the mosquito innate immune system in vitro...
  85. pmc Bionomics of the malaria vector Anopheles farauti in Temotu Province, Solomon Islands: issues for malaria elimination
    Hugo Bugoro
    National Vector Borne Disease Control Programme, Ministry of Health, Honiara, Solomon Islands
    Malar J 10:133. 2011
    In the Solomon Islands, the Malaria Eradication Programmes of the 1970s virtually eliminated the malaria vectors: Anopheles punctulatus and Anopheles koliensis, both late night biting, endophagic species...
  86. ncbi Evolutionary forces on Anopheles: what makes a malaria vector?
    Anna Cohuet
    Institut de Recherche pour le Developpement, UR016, Characterization and control of vector populations, Montpellier, France
    Trends Parasitol 26:130-6. 2010
    ..Most mosquitoes are dead ends for the parasite, and only limited ranges of Anopheles are able to transmit Plasmodium to humans...
  87. ncbi The use of remotely sensed environmental data in the study of malaria
    Vanessa Machault
    Département d Infectiologie de Terrain, Equipe 7 Maladies Emergentes et Moustiques, Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Institut de Recherche Biomédicale des Armées, Allée du Médecin Colonel Jamot, Marseille Cedex 07, France
    Geospat Health 5:151-68. 2011
    ....
  88. pmc A cyclic GMP signalling module that regulates gliding motility in a malaria parasite
    Robert W Moon
    Wellcome Trust Sanger Institute, Cambridge Hinxton, United Kingdom
    PLoS Pathog 5:e1000599. 2009
    ..These data demonstrate an important function for signalling through cGMP, and most likely PKG, in dynamically regulating ookinete gliding during the transmission of malaria to the mosquito...
  89. ncbi Blood-feeding behaviour of the malarial mosquito Anopheles arabiensis: implications for vector control
    I Tirados
    FARM Africa, London, U K
    Med Vet Entomol 20:425-37. 2006
    Feeding behaviour of the malaria vector Anopheles arabiensis Patton (Diptera: Culicidae) was monitored for 12 months (March 2003-February 2004) in the Konso District of southern Ethiopia (5 degrees 15'N, 37 degrees 28'E)...
  90. pmc FlyMine: an integrated database for Drosophila and Anopheles genomics
    Rachel Lyne
    Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK
    Genome Biol 8:R129. 2007
    ..It provides web access to integrated data at a number of different levels, from simple browsing to construction of complex queries, which can be executed on either single items or lists...
  91. pmc Highly focused anopheline breeding sites and malaria transmission in Dakar
    Vanessa Machault
    Unité d entomologie médicale, Equipe 7 Maladies Emergentes et Moustiques, Institut de Medecine Tropicale du Service de Sante des Armees, Allée du Médecin Colonel Jamot, Parc du Pharo, 13262 Marseille cedex 07, France
    Malar J 8:138. 2009
    ..Ecological heterogeneity of malaria transmission was investigated in Dakar, in order to characterize the Anopheles breeding sites in the city and to study the dynamics of larval density and adult aggressiveness in ten ..
  92. pmc House design modifications reduce indoor resting malaria vector densities in rice irrigation scheme area in western Kenya
    Harrysone Atieli
    Kenya Medical Research Institute, Kisumu, Kenya
    Malar J 8:108. 2009
    ..A randomized-controlled study was, therefore, undertaken to determine the effects of this method of vector control on the density of indoor resting malaria vectors in a rice irrigation scheme area in lowlands of western Kenya...
  93. ncbi Bacteria in midguts of field-collected Anopheles albimanus block Plasmodium vivax sporogonic development
    Lilia Gonzalez-Ceron
    Centro de Investigacion de Paludismo, Instituto Nacional de Salud Publica, Mexico
    J Med Entomol 40:371-4. 2003
    Bacterial infections were investigated in midguts of insectary and field-collected Anopheles albimanus Weidemann from southern Mexico. Serratia marcescens, Enterobacter cloacae and Enterobacter amnigenus 2, Enterobacter sp...
  94. ncbi Effect of temperature and inter-specific competition on the development and survival of Anopheles gambiae sensu stricto and An. arabiensis larvae
    Matthew J Kirby
    School of Biological and Biomedical Sciences, Durham University, Science Laboratories, UK
    Acta Trop 109:118-23. 2009
    The two major African malaria vectors Anopheles gambiae sensu stricto and An. arabiensis are sibling species that occupy different climatic niches but are frequently found in the same larval habitats...
  95. pmc Developmental and evolutionary basis for drought tolerance of the Anopheles gambiae embryo
    Yury Goltsev
    Department of Mol Cell Biology, Division of Genetics Genomics and Development, Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA
    Dev Biol 330:462-70. 2009
    ..Whole-genome transcriptome assays were performed with isolated serosa from Anopheles gambiae embryos...
  96. pmc Human antibody response to Anopheles gambiae saliva: an immuno-epidemiological biomarker to evaluate the efficacy of insecticide-treated nets in malaria vector control
    Papa M Drame
    Institut de recherche pour le developpement IRD, UR024 Epidémiologie et Prévention Unit, Dakar, Senegal
    Am J Trop Med Hyg 83:115-21. 2010
    ..This study investigates a potential immunological marker, based on human antibody responses to Anopheles saliva, as a new indicator to evaluate the efficacy of insecticide-treated nets (ITNs)...
  97. pmc Community-wide benefits of targeted indoor residual spray for malaria control in the western Kenya highland
    Guofa Zhou
    Program in Public Health, College of Health Sciences, University of California, Irvine, CA 92697 4050, USA
    Malar J 9:67. 2010
    ..Where malaria transmission is concentrated around focal points, however, targeted IRS may pose a feasible alternative to mass spraying. Here, the impact of targeted IRS was assessed in the highlands of western Kenya...
  98. pmc Wind direction and proximity to larval sites determines malaria risk in Kilifi District in Kenya
    Janet T Midega
    KEMRI Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research Coast, PO Box 230, Kilifi 80108, Kenya
    Nat Commun 3:674. 2012
    ..Here we describe the spatial relationship between the location of Anopheles larval sites and human malaria infection in a cohort study of 642 children, aged 1-10-years-old...
  99. pmc Malaria in selected non-Amazonian countries of Latin America
    Myriam Arevalo-Herrera
    Centro de Investigación Científica Caucaseco, Colombia
    Acta Trop 121:303-14. 2012
    ..2%) followed by P. falciparum (25.7%) and P. malariae (0.1%), and no less than 10 Anopheles species have been identified as primary or secondary malaria vectors...
  100. pmc Spatial and temporal dynamics of malaria transmission in rural Western Kenya
    Nyaguara Amek
    Kenya Medical Research Institute Centers for Disease Control and Prevention CDC Research and Public Health Collaboration, P O Box 1578, Kisumu, Kenya
    Parasit Vectors 5:86. 2012
    ..There are few studies examining the extent and drivers of local variation in malaria exposure in endemic areas...
  101. pmc Reduction in host-finding behaviour in fungus-infected mosquitoes is correlated with reduction in olfactory receptor neuron responsiveness
    Justin George
    Department of Entomology, Pennsylvania State University, University Park, PA 16802, USA
    Malar J 10:219. 2011
    ..Fungal entomopathogens formulated as biopesticides and applied as insecticide residual sprays could augment current control strategies and mitigate the evolution of resistance to chemical-based insecticides...

Research Grants74

  1. Genomics of Antiviral Responses of Anopheles gambiae Against O'nyong-nyong Virus
    Young S Hong; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This is an exploratory project (R21) that will utilize a mosquito Anopheles gambiae as a model organism to discover genes and gene products involved in mosquito immune responses against arbovirus ..
  2. Latin American Center for Malaria Research and Control
    SOCRATES HERRERA VALENCIA; Fiscal Year: 2013
    ..will address major gaps in our understanding of the ecology, behavior, vector potential, and control of Anopheles malaria vectors to guide the development and implementation of more effective integrated Vector Management (IVM) ..
  3. Analysis of the functions of axon guidance genes during vector mosquito developme
    MOLLY DUMAN SCHEEL; Fiscal Year: 2012
    ..These studies will include the yellow and dengue fever virus vector Aedes aegypti, as well as the malaria vector Anopheles gambiae...
  4. Genome-wide Identification of Immediate Early Genes in Insects
    Anandasankar Ray; Fiscal Year: 2012
    ..in three species of insects including Drosophila melanogaster, Drosophila pseudoobscura and the malaria vector Anopheles gambiae...
  5. Insulin, IGF and Insulin Signaling: effects on Anopheles lifespan and immunity
    MICHAEL ALLEN RIEHLE; Fiscal Year: 2012
    ..insulin and IGF-1 can stimulate the ISC in the midgut and other tissues, such as the fat body, in the mosquito Anopheles stephensi...
  6. Genetic Analysis of Mosquito Metamorphosis
    James T Nishiura; Fiscal Year: 2012
    ..These include the sequencing of the Anopheles gambiae[19], Aedes aegypti [20] and Culex pipiens genomes[21], developing techniques to produce stable ..
  7. A semi field trial test on efficacy of transgenic antimalarial biocontrol fungi
    Raymond J St Leger; Fiscal Year: 2013
    ..potential of transgenic Metarhizium in an area of Burkina Faso with very high densities of the malaria vector Anopheles gambiae (up to 200 bites/person/night) and Plasmodium falciparum sporozoite rates around 3%...
  8. Human T Cell Immunology of Plasmodium Vivax Malaria
    Anthony P Cannella; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Malaria, caused by four Plasmodium species transmitted between humans and Anopheles mosquitoes, continues to be a major global public health problem...
  9. Molecular genetic control of the immature female mosquito vector
    Helen Benes; Fiscal Year: 2012
    ..We will test this hypothesis in Anopheles gambiae and Aedes aegypti by the following Specific Aims...
  10. The function(s) of serpin-2 in mosquito immunity and physiology
    Kristin Michel; Fiscal Year: 2013
    ..on a new insecticide target, the serine protease inhibitor serpin (SRPN)2 from the African malaria mosquito, Anopheles gambiae s.s....
  11. Infectious Disease Genomics and Bioinformatics Training in Brazil
    Jessica C Kissinger; Fiscal Year: 2013
    ..These organisms include: Plasmodium sp., Trypanosoma cruzi. Toxoplasma gondii, Schistosoma mansoni. Anopheles, Blomphalaria and Humans...
  12. Function of Laccases in Anopheles gambiae
    Michael R Kanost; Fiscal Year: 2010
    ..The long term goals of this research are to determine the function of six putative laccases in the mosquito, Anopheles garnbiae, to increase our understanding of laccase-substrate interactions, and eventually to use this ..
  13. Systematic analysis of cell death regulation in mosquitoes
    Lei Zhou; Fiscal Year: 2009
    ..The genome project for the primary malaria vector, Anopheles gambiae, revealed a significant expansion of the IAP and caspase gene families when compared to Drosophila...
  14. Highly finished chromosome-based genome assembly for Anopheles gambiae
    Igor V Sharakhov; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The African malaria mosquito Anopheles gambiae, because of its epidemiological importance, was the first disease vector sequenced. In order to perform full genome annotation for An...
  15. Transcriptomics and Population Genetics of Mosquito Resistance to Pyrethroids
    Mariangela Bonizzoni; Fiscal Year: 2013
    ..The understanding of the molecular mechanisms of insecticide resistance in Anopheles gambiae mosquitoes, the most important malaria vector in sub-Saharan Africa, has progressed in association with ..
  16. Malaria transmission potential of the Anopheles punctutatus species complex
    Lisa Reimer; Fiscal Year: 2013
    ..The Anopheles punctulatus complex includes 12 species of mosquitoes, encompassing many of the major malaria vectors in Papua ..
  17. New Alphavirus Expression Systems in Mosquitoes
    Kenneth E Olson; Fiscal Year: 2012
    ..Genome sequence information and other bioinformatics are available for three major vector species (Anopheles gambiae, Aedes aegypti and Culex pipiens)...
  18. Ecological and genetic determinants of malaria transmitting behaviors in the Afri
    Gregory C Lanzaro; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Sequencing of the genome of Anopheles gambiae s.s., one of the primary mosquito vector of malaria in Africa, has been touted as ".....
  19. EXPRESSION OF EXOGENOUS GENES IN VECTOR MOSQUITOES
    Anthony A James; Fiscal Year: 2013
    ..of single-chain antibodies (scFv) that disable Plasmodium falciparum In the midgut and hemolymph of transgenic Anopheles stephensi;2) construct and test in parasite-challenge assays transgenic An...
  20. Ion transport and motility in larval mosquito stomach
    David F Moffett; Fiscal Year: 2010
    ..in two mosquito species: the yellow fever mosquito (Aedes aegypti) and the malaria mosquito of subsaharan Africa Anopheles gambiae. Specifically we will determine: 1...
  21. An.gambiae immune signaling gene SNPs and natural P. falciparum infection
    Shirley Luckhart; Fiscal Year: 2013
    ..insulin, and TGF-[unreadable] signaling pathways in the regulation of malaria parasite development in the Anopheles gambiae midgut...
  22. Function of Guy1, a Y-specific gene of Anopheles stephensi
    Zhijian Jake Tu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anopheles mosquitoes are the primary vectors of malaria, one of the most deadly and costly diseases in human history...
  23. Development of a Field Applicable Screening Tool (FAST) kit for detecting resista
    MARTIN JAMES DONNELLY; Fiscal Year: 2013
    ..The specific aims of this proposal are to: i) identify genes that render Anopheles gambiae s.l...
  24. Intracellular transfer of cholesterol in mosquitoes
    Que Lan; Fiscal Year: 2010
    ..SCPIs are effective larvicides in Aedes aegypti, Anopheles gambiae and Culex pipiens, indicating that a sterol carrier protein-2 has functional similarity in different ..
  25. Investigating the Role of Cellular Signaling in Liver-Stage Malaria Infection
    Alexis Kaushansky; Fiscal Year: 2012
    ..The parasites enter the human host through the bite of the female Anopheles mosquito and first infect liver hepatocytes, before moving to the blood infection that causes all disease...
  26. PHYSIOLOGY OF INSECT AMINO ACID TRANSPORT
    Dmitri Y Boudko; Fiscal Year: 2010
    ..NAT-SLC6 population and analyze the impacts of pharmacogenetic NAT suppression in two model vector mosquitoes, Anopheles gambiae and Aedes aegypti...
  27. Examination of Odorant Receptors in Vector Mosquitoes
    Laurence J Zwiebel; Fiscal Year: 2013
    ..several elements of the olfactory signal transduction cascade in the principal African malaria vector mosquito Anopheles gambiae sensu stricto and the arbovirus vector Aedes aegypti...
  28. Transgenic Mosquitoes for Improved Malaria Sporozoite Vaccine Manufacture
    Peter F Billingsley; Fiscal Year: 2013
    ..This project will develop a strain of genetically modified (GM) Anopheles stephensi mosquitoes highly susceptible to PfSPZ infections...
  29. Functional Genomics of Inversion 2La in Anopheles gambiae
    Nora J Besansky; Fiscal Year: 2013
    ..even in vectors considered to be primarily "endophilic" and "endophagic" (indoor resting and biting) such as Anopheles gambiae. In Africa, A. gambiae is the most important vector...
  30. Identifying community-based solutions that improve insecticide-treated net (ITN)
    Kacey C Ernst; Fiscal Year: 2012
    ..with actual risk as determined through parallel parasite prevalence surveys and pyrethrum spray catches of Anopheles. From the cross-sectional participants we will identify positive deviants, community members who own and use ..
  31. Development of vector-specific, resistance-breaking insecticides to reduce malari
    Paul R Carlier; Fiscal Year: 2013
    ..the first line of defense against disease transmission, but emerging resistant strains of the disease vector (Anopheles gambiae) threaten to render these ITNs ineffective...
  32. Mosquito-parasite interactions and filariasis transmission in Papua New Guinea
    BRUCE MARTIN CHRISTENSEN; Fiscal Year: 2012
    ..During the last year, we conducted preliminary studies in Papua New Guinea (PNG) that demonstrate that Anopheles punctulatus, a principal vector of W...
  33. Novel Plasmodial Surface Anion Channel Inhibitors as Antimalarial Drugs
    Michelle M Butler; Fiscal Year: 2013
    ..The malaria parasites, most importantly P. falciparum, require two hosts, which are humans and female Anopheles mosquitoes. Disease is transmitted to humans from the bite of an infected mosquito...
  34. Evaluating Hztransib as a potential gene driving mechanism in Anophelene mosquito
    Xianchun Li; Fiscal Year: 2010
    ..While anti-malarial effector genes have been identified and successfully engineered into Anopheles mosquitoes, a mechanism for driving the effector genes through wild populations is not currently available...
  35. The Neuropeptide Control of Mosquito Host-Seeking Behavior
    Jeff Liesch; Fiscal Year: 2013
    ..aegypti as well as other mosquitoes such as the malarial vector Anopheles gambiae...
  36. New Role for a Conserved Plasmodium Transcription Factor
    Lawrence W Bergman; Fiscal Year: 2013
    ..falciparum. The life cycle of Plasmodium species is spent between two hosts, Anopheles mosquitoes in which the parasite undergoes one sexual and multiple rounds of asexual divisions, and a vertebrate ..
  37. Experimental identification of microRNA targets in mosquitoes during Plasmodium i
    Jinsong Zhu; Fiscal Year: 2012
    ..In Anopheles gambiae mosquitoes, levels of some microRNAs are markedly affected in the midgut by Plasmodium infection...
  38. Recombination-mediated cassette exchange in Aedes aegypti mosquitoes
    Zach N Adelman; Fiscal Year: 2013
    ..recombination i cis and promote RMCE in the embryos of the dengue vector Aedes aegypti and the malaria vector Anopheles gambiae;(2) generate transgenic docking strains based on the best candidate heterospecific lox sites and ..
  39. Human Reservoirs of Plasmodium vivax Transmission in the Peruvian Amazon
    Joseph M Vinetz; Fiscal Year: 2010
    ..vivax transmission dynamics. Membrane feeding studies will be performed using local Anopheles darlingi mosquitoes and local P...
  40. Malaria Vector Population Genetic Division and Vector Competence in Hainan Island
    Liwang Cui; Fiscal Year: 2013
    ..extensive use of insecticides for malaria control has led to an initially sharp decrease and recently rebound of Anopheles miminus, the key malaria vector in China and Southeast Asia...
  41. Effects of Blood Meal on Cellular Immunity in Mosquitoes
    William B Bryant; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Malaria continues to be a global health problem where the mosquito Anopheles gambiae s.s. serves as a major vector for Plasmodium falciparum...
  42. Endogenous insulin-like peptides and control of malaria infection in the mosquito
    JOSE ENRIQUE PIETRI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The mosquito Anopheles gambiae is the primary vector of the deadly human malaria parasite Plasmodium falciparum in sub-Saharan Africa...
  43. Cuticular proteins of Anopheles gambiae
    Judith Willis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anopheles gambiae, the major vector of malaria, uses ~2% of its protein-coding genes for structural cuticular proteins...
  44. Receptors and Neurons Mediating Acid Taste in Drosophila
    ANUPAMA ARUN DAHANUKAR; Fiscal Year: 2013
    ..by taste neurons may be important for behaviors of human blood-feeding insects such as Aedes aegypti and Anopheles gambiae, which transmit deadly diseases...
  45. Molecular Improvement of Bacterial Mosquito Larvicides
    Brian A Federici; Fiscal Year: 2013
    ..Combined, these studies will strengthen the basis for using larvicides as component of integrated vector management programs for controlling species belonging to the most important vector genera, namely, Anopheles, Aedes, and Culex.
  46. Genetic basis of salt tolerance in Anopheles gambiae s.l.
    Nora J Besansky; Fiscal Year: 2013
    ....
  47. Discovery of Marine Invertebrate-Derived Antimalarial Agents
    Amy E Wright; Fiscal Year: 2013
    ..is transmitted and although malaria is not a current threat in the US, the transmission vector for the parasite, Anopheles mosquitoes, is widely prevalent and there remains a constant risk of reintroduction of malaria into the US...
  48. Genomics of mosquito resistance to Plasmodium
    Kenneth D Vernick; Fiscal Year: 2012
    ..In the current project period, we carried out a field-based genetic survey of the major human malaria vector, Anopheles gambiae, in Mali, West Africa...
  49. Studying the oviposition of Anopheles gambiae: the development of novel tools for
    Steve Lindsay; Fiscal Year: 2013
    ..This project aims to develop more efficient and cost-effective methods for controlling and monitoring Anopheles gambiae populations, the major vector of malaria in Africa...
  50. The Role of Odorant Binding Proteins in Anopheline Mosquito Odor Perception
    Marika F Walter; Fiscal Year: 2010
    The work proposed here will investigate the specificity of odorant recognition in the malaria mosquito Anopheles gambiae and correlate odor stimuli with quantifiable physiological and behavioral responses...
  51. Targeted gene inactivation in Anopeles gambiae via artificial nucleases
    Laurence J Zwiebel; Fiscal Year: 2013
    ..by applicant): The ability to genetically manipulate insect disease vectors such as the malaria vector mosquito Anopheles gambiae remains rudimentary relative to the abundance of molecular tools that are currently available in model ..
  52. Disruption of Host-Seeking Behavior in Anopheles Gambiae Mosquitoes using Odorant
    Anandasankar Ray; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The female Anopheles gambiae mosquito is an extremely efficient vector for the malarial parasite Plasmodium falciparum and transmits this deadly disease to nearly 500 million people, causing nearly ..
  53. The Floral Dimension of African Malaria
    Woodbridge A Foster; Fiscal Year: 2012
    ..It was assumed that plants play no significant role in adult Anopheles gambiae biology and therefore would be irrelevant to Plasmodium transmission...
  54. Dscam function in innate immunity
    George Dimopoulos; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anopheles gambiae and other insects utilize a variety of strategies to combat microbial invaders...
  55. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    Brian P Lazzaro; Fiscal Year: 2010
    ..Under this proposal, we will explore the genetic basis for natural resistance to malaria in Anopheles gambiae, the most common and destructive vector of human malaria...
  56. Dissection of Anopheles Responses to Plasmodium Infected Blood
    George Dimopoulos; Fiscal Year: 2013
    ..defense, we have shown that the IMD pathway is a conserved key player in regulating resistance of several Anopheles species to multiple malaria parasite species including the human pathogen P. falciparum...
  57. Malaria Vector Biology in Brazil: Genetics and Ecology
    Jan E Conn; Fiscal Year: 2012
    ..We have convincing data from peri-urban settings that Anopheles marajoara of the Albitarsis Complex increases in importance and even replaces the primary malaria vector An...
  58. A genetic resource for Anopheles immunity research
    DAVID A O'BROCHTA; Fiscal Year: 2013
    ..will result in the creation of a genetic resource consisting of transgenic lines of the human malaria mosquito Anopheles stephensi expressing the transcription factor Gal4 specifically in hemocytes...
  59. Pyrethroid Resistance in Malaria Mosquito Anopheles sinensis
    Bin Chen; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Malaria is one of the most important mosquito-borne diseases, and Anopheles sinensis mosquito is the predominant malaria vector in China...
  60. Chromosome-based genome assembly for Culex quinquefasciatus
    Maria Sharakhova; Fiscal Year: 2013
    ..of advanced genome-based strategies for vector control, the genomes of the three major mosquito genera-Anopheles, Aedes, and Culex-were sequenced over the last decade. The genome assembly of Cx...
  61. Genetic tools for manipulation of mosquitoes
    Susan M Paskewitz; Fiscal Year: 2013
    ..persistence of plasmid DNA and reporter gene activity from the egg to the adult stage in both Aedes aegypti and Anopheles gambiae, following delivery of the plasmids to the staged females...
  62. Outdoor Resting and Sugar Feeding Behaviors of African Malaria Vectors
    John C Beier; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This project focuses on the outdoor resting and sugar-feeding behaviors of Anopheles malaria vector populations in Mali, West Africa, where, as in most African countries, malaria is a serious public ..
  63. POPULATION GENETICS OF AEDES AEGYPTI IN THE WEST INDIES
    David Severson; Fiscal Year: 1999
    ..to construct a RFLP linkage map for the mosquito Anopheles gambiae, the host for the human malaria...
  64. Mosquitocidal Avtive Clostridium Toxins
    Sarjeet Gill; Fiscal Year: 2007
    ..However, the use of both these bacteria against Anopheles vectors of malaria has been much more limited, in part due to their lower activity against mosquitoes of this ..
  65. Mosquito Immunity to Alphaviruses
    Brian Foy; Fiscal Year: 2006
    ..We have also made use of currently available genome data for Anopheles gambiae and Aedes aegypti mosquitoes, and with these data are beginning to characterize barriers to ..
  66. Functional Domains of Bacillus thuringiensis Endotoxins
    DONALD DEAN; Fiscal Year: 2007
    ..the binding and mechanism of action of several mosquitocidal proteins against key pestiferous mosquito species, Anopheles gambiae, Aedes aegypti and Culex quinquefaciatus. The main mosquitocidal toxins of interest are the toxins of B...
  67. GENETIC AND ECOLOGIC DIFFERENTIATION OF MALARIA VECTORS
    LEON LOUNIBOS; Fiscal Year: 1991
    ..Nearly 15 million of these cases occur in neotropical America transmitted by Anopheles from five species complexes...
  68. Nutritional Ecology of Adult Anopheles gambiae
    WOODBRIDGE FOSTER; Fiscal Year: 2006
    DESCRIPTION (provided by the applicant): The mosquito Anopheles gambiae is the primary vector of malaria in equatorial Africa. Contrary to what is generally understood, adult An...
  69. Catalytic definition of insecticide-metabolizing P450s
    MARY SCHULER; Fiscal Year: 2007
    ..that they exist in over 500 species with many in species that significantly impact human health, such as the Anopheles mosquitoes that vector malarial parasites (estimated to kill as many as 3 million people per year) and the Aedes ..
  70. Microbial Mediation of Habitat Selection and Production
    Edward Walker; Fiscal Year: 2006
    ..In subSaharan Africa, the risk of malaria is due to exposure to infectious bites of mosquitoes, particularly Anopheles gambiae...
  71. Population cytogenetics of Anopheles moucheti and Anopheles nili
    Igor Sharakhov; Fiscal Year: 2009
    ..Mosquitoes of subgenus Cellia - Anopheles gambiae, An. arabiensis, An. funestus, An. moucheti, and An...
  72. CYROBIOLOGICAL PRESERVATION OF ANOPHELES EMBRYOS
    Peter Mazur; Fiscal Year: 2001
    ..Many aspects of the interaction between the Anopheles mosquito and the Plasmodium parasite are under genetic control, and for these reasons the molecular genetics of ..
  73. Molecular Markers for Anopheles Gambiae Age Grading
    Guiyun Yan; Fiscal Year: 2009
    Information on population age structure of Anopheles gambiae mosquitoes under natural conditions is fundamental to the understanding of vectorial capacity, and it is crucial for assessing the impact of vector control measures on malaria ..
  74. The Aedes aegypti Genome Project
    David Severson; Fiscal Year: 2003
    ..Whole genome sequence data is available for humans, Drosophila melanogaster, the malaria parasite vector Anopheles gambiae, the malaria parasite Plasmodium falciparum, and several other parasite genome projects are underway...