aedes

Summary

Summary: A genus of mosquitoes (CULICIDAE) frequently found in tropical and subtropical regions. YELLOW FEVER and DENGUE are two of the diseases that can be transmitted by species of this genus.

Top Publications

  1. ncbi Dengue
    Scott B Halstead
    Supportive Research and Development, Pediatric Dengue Vaccine Initiative, Internal Vaccine Institute, Seoul, South Korea
    Lancet 370:1644-52. 2007
  2. ncbi Global spread and persistence of dengue
    Jennifer L Kyle
    Division of Infectious Diseases, School of Public Health, and Graduate Group in Microbiology, University of California, Berkeley, California 94720 7354, USA
    Annu Rev Microbiol 62:71-92. 2008
  3. ncbi Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission
    A A Hoffmann
    Bio21 Institute, Department of Genetics, The University of Melbourne, Victoria 3010, Australia
    Nature 476:454-7. 2011
  4. ncbi A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium
    Luciano A Moreira
    School of Biological Sciences, The University of Queensland, Brisbane QLD 4072, Australia
    Cell 139:1268-78. 2009
  5. ncbi The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations
    T Walker
    School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    Nature 476:450-3. 2011
  6. pmc Genome sequence of Aedes aegypti, a major arbovirus vector
    Vishvanath Nene
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 316:1718-23. 2007
  7. pmc A single mutation in chikungunya virus affects vector specificity and epidemic potential
    Konstantin A Tsetsarkin
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS Pathog 3:e201. 2007
  8. pmc Impact of daily temperature fluctuations on dengue virus transmission by Aedes aegypti
    Louis Lambrechts
    Department of Virology, Institut Pasteur, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 108:7460-5. 2011
  9. ncbi Infection with chikungunya virus in Italy: an outbreak in a temperate region
    G Rezza
    Department of Infectious, Parasitic, and Immunomediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Lancet 370:1840-6. 2007
  10. ncbi Critical review of the vector status of Aedes albopictus
    N G Gratz
    Med Vet Entomol 18:215-27. 2004

Detail Information

Publications379 found, 100 shown here

  1. ncbi Dengue
    Scott B Halstead
    Supportive Research and Development, Pediatric Dengue Vaccine Initiative, Internal Vaccine Institute, Seoul, South Korea
    Lancet 370:1644-52. 2007
    ..Dengue 1 virus became prevalent in Hawaii where it was transmitted by Aedes albopictus, producing a classic virgin soil epidemic, with clinical disease seen largely in adults...
  2. ncbi Global spread and persistence of dengue
    Jennifer L Kyle
    Division of Infectious Diseases, School of Public Health, and Graduate Group in Microbiology, University of California, Berkeley, California 94720 7354, USA
    Annu Rev Microbiol 62:71-92. 2008
    ..What is known, as well as gaps in knowledge, is emphasized in light of future prospects for control and prevention of this pandemic disease...
  3. ncbi Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission
    A A Hoffmann
    Bio21 Institute, Department of Genetics, The University of Melbourne, Victoria 3010, Australia
    Nature 476:454-7. 2011
    ..Here we describe how the wMel Wolbachia infection, introduced into the dengue vector Aedes aegypti from Drosophila melanogaster, successfully invaded two natural A...
  4. ncbi A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium
    Luciano A Moreira
    School of Biological Sciences, The University of Queensland, Brisbane QLD 4072, Australia
    Cell 139:1268-78. 2009
    ..The successful introduction of a life-shortening strain of Wolbachia into the dengue vector Aedes aegypti that halves adult lifespan has recently been reported...
  5. ncbi The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations
    T Walker
    School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    Nature 476:450-3. 2011
    ..for dengue are very limited and currently focus on reducing population abundance of the major mosquito vector, Aedes aegypti...
  6. pmc Genome sequence of Aedes aegypti, a major arbovirus vector
    Vishvanath Nene
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 316:1718-23. 2007
    We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles ..
  7. pmc A single mutation in chikungunya virus affects vector specificity and epidemic potential
    Konstantin A Tsetsarkin
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS Pathog 3:e201. 2007
    ..fitness for different vector species, viral infectivity, dissemination, and transmission of CHIKV were compared in Aedes albopictus, the species implicated in the epidemic, and the recognized vector Ae. aegypti...
  8. pmc Impact of daily temperature fluctuations on dengue virus transmission by Aedes aegypti
    Louis Lambrechts
    Department of Virology, Institut Pasteur, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 108:7460-5. 2011
    ..diurnal temperature range (DTR) affects two important parameters underlying dengue virus (DENV) transmission by Aedes aegypti...
  9. ncbi Infection with chikungunya virus in Italy: an outbreak in a temperate region
    G Rezza
    Department of Infectious, Parasitic, and Immunomediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Lancet 370:1840-6. 2007
    Chikungunya virus (CHIKV), which is transmitted by Aedes spp mosquitoes, has recently caused several outbreaks on islands in the Indian Ocean and on the Indian subcontinent. We report on an outbreak in Italy.
  10. ncbi Critical review of the vector status of Aedes albopictus
    N G Gratz
    Med Vet Entomol 18:215-27. 2004
    The mosquito Aedes (Stegomyia) albopictus (Skuse) (Diptera: Culicidae), originally indigenous to South-east Asia, islands of the Western Pacific and Indian Ocean, has spread during recent decades to Africa, the mid-east, Europe and the ..
  11. ncbi Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses
    John S Mackenzie
    Australian Biosecurity Cooperative Research Centre, Curtin University of Technology, Perth, Western Australia
    Nat Med 10:S98-109. 2004
    ....
  12. pmc Sequencing of Culex quinquefasciatus establishes a platform for mosquito comparative genomics
    Peter Arensburger
    Center for Disease Vector Research, University of California Riverside, Riverside, CA 92521, USA
    Science 330:86-8. 2010
    ..quinquefasciatus: Its repertoire of 18,883 protein-coding genes is 22% larger than that of Aedes aegypti and 52% larger than that of Anopheles gambiae with multiple gene-family expansions, including olfactory ..
  13. pmc Wolbachia induces reactive oxygen species (ROS)-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegypti
    Xiaoling Pan
    Department of Entomology and Genetics Program, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 109:E23-31. 2012
    ..In this study, we have deciphered how Wolbachia infection affects the Aedes aegypti host in inducing resistance to DENV...
  14. pmc Gene amplification, ABC transporters and cytochrome P450s: unraveling the molecular basis of pyrethroid resistance in the dengue vector, Aedes aegypti
    Vassiliki Bariami
    Department of Biology, University of Crete, Haraklio, Greece
    PLoS Negl Trop Dis 6:e1692. 2012
    Pyrethroid insecticides are widely utilized in dengue control. However, the major vector, Aedes aegypti, is becoming increasingly resistant to these insecticides and this is impacting on the efficacy of control measures...
  15. pmc Spread of the tiger: global risk of invasion by the mosquito Aedes albopictus
    Mark Q Benedict
    Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Vector Borne Zoonotic Dis 7:76-85. 2007
    b>Aedes albopictus, commonly known as the Asian tiger mosquito, is currently the most invasive mosquito in the world...
  16. pmc Insecticide resistance in the dengue vector Aedes aegypti from Martinique: distribution, mechanisms and relations with environmental factors
    Sebastien Marcombe
    Unité mixte de recherche MIVEGEC UM1 CNRS 5290 IRD 224, Institut de recherche pour le developpement IRD, Montpellier, France
    PLoS ONE 7:e30989. 2012
    ..The viruses responsible for dengue are transmitted by Aedes aegypti, an indoor day-biting mosquito...
  17. ncbi Chikungunya: a re-emerging virus
    Felicity J Burt
    Department of Medical Microbiology and Virology, National Health Laboratory Services Universitas and University of the Free State, Bloemfontein, South Africa
    Lancet 379:662-71. 2012
    In the past decade, chikungunya--a virus transmitted by Aedes spp mosquitoes--has re-emerged in Africa, southern and southeastern Asia, and the Indian Ocean Islands as the cause of large outbreaks of human disease...
  18. pmc Consequences of the expanding global distribution of Aedes albopictus for dengue virus transmission
    Louis Lambrechts
    Department of Virology, Institut Pasteur, Paris, France
    PLoS Negl Trop Dis 4:e646. 2010
    The dramatic global expansion of Aedes albopictus in the last three decades has increased public health concern because it is a potential vector of numerous arthropod-borne viruses (arboviruses), including the most prevalent arboviral ..
  19. pmc The Aedes aegypti toll pathway controls dengue virus infection
    Zhiyong Xi
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Pathog 4:e1000098. 2008
    b>Aedes aegypti, the mosquito vector of dengue viruses, utilizes its innate immune system to ward off a variety of pathogens, some of which can cause disease in humans...
  20. pmc The role of human movement in the transmission of vector-borne pathogens
    Steven T Stoddard
    Entomology, University of California, Davis, California, United States of America
    PLoS Negl Trop Dis 3:e481. 2009
    ..Here we develop a conceptual model to evaluate the importance of variation in exposure due to individual human movements for pathogen transmission, focusing on mosquito-borne dengue virus...
  21. pmc Impact of Wolbachia on infection with chikungunya and yellow fever viruses in the mosquito vector Aedes aegypti
    Andrew F van den Hurk
    Public Health Virology, Communicable Diseases Unit, Queensland Health Forensic and Scientific Services, Coopers Plains, Australia
    PLoS Negl Trop Dis 6:e1892. 2012
    ..The viruses are primarily transmitted by Aedes aegypti, a highly domesticated mosquito species that is notoriously difficult to control...
  22. pmc Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes
    Zakaria Kambris
    Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Science 326:134-6. 2009
    ..strain wMelPop reduces the longevity of its Drosophila melanogaster host and, when introduced into the mosquito Aedes aegypti, halves its life span...
  23. ncbi Potential effect of population and climate changes on global distribution of dengue fever: an empirical model
    Simon Hales
    Department of Public Health, Wellington School of Medicine and Health Sciences, PO Box 7343, Mein Street, Wellington, New Zealand
    Lancet 360:830-4. 2002
    ..Our aim was to investigate the potential effects of global climate change on human health, and in particular, on the transmission of vector-borne diseases...
  24. ncbi Dengue virus-mosquito interactions
    Scott B Halstead
    Pediatric Dengue Vaccine Initiative, Bethesda, MD 20852, USA
    Annu Rev Entomol 53:273-91. 2008
    The mosquito Aedes aegypti is more widely dispersed now than at any time in the past, placing billions of humans at risk of infection with one or more of the four dengue viruses...
  25. pmc Genetic elimination of dengue vector mosquitoes
    Megan R Wise de Valdez
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Proc Natl Acad Sci U S A 108:4772-5. 2011
    ..A transgenic strain, designated OX3604C, of the major dengue vector, Aedes aegypti, was engineered to have a repressible female-specific flightless phenotype...
  26. pmc VectorBase: a data resource for invertebrate vector genomics
    Daniel Lawson
    European Bioinformatics Institute EMBL EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK
    Nucleic Acids Res 37:D583-7. 2009
    ..Currently, VectorBase contains genome information for three mosquito species: Aedes aegypti, Anopheles gambiae and Culex quinquefasciatus, a body louse Pediculus humanus and a tick species Ixodes ..
  27. ncbi Stable introduction of a life-shortening Wolbachia infection into the mosquito Aedes aegypti
    Conor J McMeniman
    School of Integrative Biology, University of Queensland, Brisbane 4072, Australia
    Science 323:141-4. 2009
    ..a life-shortening strain of the inherited bacterial symbiont, Wolbachia, into the major mosquito vector of dengue, Aedes aegypti, halved adult life span under laboratory conditions...
  28. pmc Fine scale spatiotemporal clustering of dengue virus transmission in children and Aedes aegypti in rural Thai villages
    In Kyu Yoon
    Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    PLoS Negl Trop Dis 6:e1730. 2012
    ..To define the dimensions of local transmission and quantify the factors that support it, we examined relationships between infected humans and Aedes aegypti in Thai villages.
  29. pmc Reciprocal tripartite interactions between the Aedes aegypti midgut microbiota, innate immune system and dengue virus influences vector competence
    Jose Luis Ramirez
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Negl Trop Dis 6:e1561. 2012
    ..It is transmitted between humans by the mosquitoes Aedes aegypti and Aedes albopictus, and at least 2.5 billion people are at daily risk of infection...
  30. pmc Two Chikungunya isolates from the outbreak of La Reunion (Indian Ocean) exhibit different patterns of infection in the mosquito, Aedes albopictus
    Marie Vazeille
    Département de Virologie Chikungunya program, Institut Pasteur, Paris, France
    PLoS ONE 2:e1168. 2007
    A Chikungunya (CHIK) outbreak hit La Réunion Island in 2005-2006. The implicated vector was Aedes albopictus. Here, we present the first study on the susceptibility of Ae...
  31. ncbi Field performance of engineered male mosquitoes
    Angela F Harris
    Mosquito Research and Control Unit MRCU, Grand Cayman, Cayman Islands
    Nat Biotechnol 29:1034-7. 2011
    ..dengue, the most promising strategies to control the disease involve targeting the predominant mosquito vector, Aedes aegypti. However, the current methods to do this are inadequate...
  32. ncbi Chikungunya, an epidemic arbovirosis
    Gilles Pialoux
    Hopital Tenon, Service des Maladies Infectieuses et Tropicales, Paris, France
    Lancet Infect Dis 7:319-27. 2007
    Chikungunya is an arboviral disease transmitted by aedes mosquitoes. The virus was first isolated in 1953 in Tanzania. Chikungunya virus is a member of the genus Alphavirus and the family Togaviridae...
  33. ncbi Area-wide management of Aedes albopictus: choice of study sites based on geospatial characteristics, socioeconomic factors and mosquito populations
    Isik Unlu
    Center for Vector Biology, Department of Entomology, Rutgers University, New Brunswick, NJ 08901, USA
    Pest Manag Sci 67:965-74. 2011
    b>Aedes (Stegomyia) albopictus (Skuse), the Asian tiger mosquito, is an introduced invasive species in the United States that is responsible for a significant proportion of service requests to local mosquito control programs...
  34. pmc Wolbachia strain wMel induces cytoplasmic incompatibility and blocks dengue transmission in Aedes albopictus
    Marcus S C Blagrove
    Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom
    Proc Natl Acad Sci U S A 109:255-60. 2012
    ..wMelPop strain was recently shown to strongly inhibit the replication of dengue virus when introduced into Aedes aegypti mosquitoes, as well as to stimulate chronic immune up-regulation...
  35. pmc Suitability of European climate for the Asian tiger mosquito Aedes albopictus: recent trends and future scenarios
    Cyril Caminade
    School of Environmental Sciences, University of Liverpool, Liverpool, UK
    J R Soc Interface 9:2708-17. 2012
    The Asian tiger mosquito (Aedes albopictus) is an invasive species that has the potential to transmit infectious diseases such as dengue and chikungunya fever...
  36. pmc Global cross-talk of genes of the mosquito Aedes aegypti in response to dengue virus infection
    Susanta K Behura
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA
    PLoS Negl Trop Dis 5:e1385. 2011
    The mosquito Aedes aegypti is the primary vector of dengue virus (DENV) infection in humans, and DENV is the most important arbovirus across most of the subtropics and tropics worldwide...
  37. pmc Transcription of detoxification genes after permethrin selection in the mosquito Aedes aegypti
    K Saavedra-Rodriguez
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1685, USA
    Insect Mol Biol 21:61-77. 2012
    ..before, during and after five generations of permethrin laboratory selection were monitored in six strains of Aedes aegypti: five F(2)-F(3) collections from the Yucatán Peninsula of Mexico and one F(2) from Iquitos, Peru...
  38. ncbi Invasions by insect vectors of human disease
    L Philip Lounibos
    Florida Medical Entomology Laboratory, University of Florida, Vero Beach, Florida 32962, USA
    Annu Rev Entomol 47:233-66. 2002
    ..From the fifteenth century to the present, successive waves of invasion of the vector mosquitoes Aedes aegypti, the Culex pipiens Complex, and, most recently, Aedes albopictus have been facilitated by worldwide ship ..
  39. pmc The endosymbiotic bacterium Wolbachia induces resistance to dengue virus in Aedes aegypti
    Guowu Bian
    Department of Entomology and Genetics Program, Michigan State University, East Lansing, Michigan, United States of America
    PLoS Pathog 6:e1000833. 2010
    ..Our results show that Wolbachia inhibits viral replication and dissemination in the main dengue vector, Aedes aegypti. Moreover, the virus transmission potential of Wolbachia-infected Ae...
  40. pmc Wolbachia-mediated resistance to dengue virus infection and death at the cellular level
    Francesca D Frentiu
    School of Biological Sciences, The University of Queensland, Brisbane, Australia
    PLoS ONE 5:e13398. 2010
    ..Recent work has shown dengue virus displays limited replication in its primary vector, the mosquito Aedes aegypti, when the insect harbors the endosymbiotic bacterium Wolbachia pipientis...
  41. pmc Dengue virus type 2 infections of Aedes aegypti are modulated by the mosquito's RNA interference pathway
    Irma Sanchez-Vargas
    Department of Microbiology, Arthropod Borne and Infectious Diseases Laboratory, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS Pathog 5:e1000299. 2009
    ..human dengue virus (DENV) infections, but little is known about the innate immune response of the mosquito vector Aedes aegypti to arbovirus infection...
  42. pmc Spatial stability of adult Aedes aegypti populations
    Roberto Barrera
    Entomology and Ecology Activity, Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico
    Am J Trop Med Hyg 85:1087-92. 2011
    Vector control programs could be more efficient by identifying the location of highly productive sites of Aedes aegypti. This study explored if the number of female adults of Ae...
  43. pmc Climate change and range expansion of the Asian tiger mosquito (Aedes albopictus) in Northeastern USA: implications for public health practitioners
    Ilia Rochlin
    Suffolk County Vector Control, Yaphank, New York, USA
    PLoS ONE 8:e60874. 2013
    The Asian tiger mosquito, Aedes albopictus (Skuse), is an invasive species with substantial biting activity, high disease vector potential, and a global distribution that continues to expand...
  44. pmc Fluctuations at a low mean temperature accelerate dengue virus transmission by Aedes aegypti
    Lauren B Carrington
    Department of Entomology, University of California Davis, Davis, California, USA
    PLoS Negl Trop Dis 7:e2190. 2013
    ..indicate that daily fluctuations around an intermediate mean temperature (26°C) reduce vector competence of Aedes aeygpti for dengue viruses (DENV)...
  45. ncbi Larval mosquito habitat utilization and community dynamics of Aedes albopictus and Aedes japonicus (Diptera: Culicidae)
    Kristen Bartlett-Healy
    Center for Vector Biology, Rutgers University, 180 Jones Avenue, New Brunswick, NJ 08901, USA
    J Med Entomol 49:813-24. 2012
    b>Aedes albopictus (Skuse) and Ae. japonicus (Theobald) are important container-inhabiting mosquitoes that transmit disease agents, outcompete native species, and continue to expand their range in the United States...
  46. ncbi Bacterial diversity of field-caught mosquitoes, Aedes albopictus and Aedes aegypti, from different geographic regions of Madagascar
    Karima Zouache
    Universite de Lyon, Lyon, France
    FEMS Microbiol Ecol 75:377-89. 2011
    ..Wild Aedes albopictus and Aedes aegypti were collected in three different geographic regions of Madagascar...
  47. ncbi Genomic analysis of detoxification genes in the mosquito Aedes aegypti
    Clare Strode
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
    Insect Biochem Mol Biol 38:113-23. 2008
    Annotation of the recently determined genome sequence of the major dengue vector, Aedes aegypti, reveals an abundance of detoxification genes...
  48. pmc C6/36 Aedes albopictus cells have a dysfunctional antiviral RNA interference response
    Doug E Brackney
    Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA
    PLoS Negl Trop Dis 4:e856. 2010
    ..Nevertheless, a recent study failed to detect an active RNAi response to West Nile virus (WNV) infection in C6/36 (Aedes albopictus) cells, a mosquito cell line frequently used to study arthropod-borne viruses (arboviruses)...
  49. pmc Female-specific flightless phenotype for mosquito control
    Guoliang Fu
    Oxitec Limited, 71 Milton Park, Oxford OX14 4RX, United Kingdom
    Proc Natl Acad Sci U S A 107:4550-4. 2010
    ..b>Aedes aegypti is the major vector of dengue viruses in its range and control of this mosquito would reduce significantly ..
  50. ncbi Influence of temperature on immature development, survival, longevity, fecundity, and gonotrophic cycles of Aedes albopictus, vector of chikungunya and dengue in the Indian Ocean
    H Delatte
    Research Unit 016, Institut de recherche pour le developpement IRD, 7 chemin de l IRAT, 97410 Saint Pierre, La Reunion, France
    J Med Entomol 46:33-41. 2009
    b>Aedes albopictus is a mosquito originating from Asia, which has extended its range worldwide the last decades. It is a competent vector for several arboviruses...
  51. pmc Discovery of insect and human dengue virus host factors
    October M Sessions
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 458:1047-50. 2009
    ..This indicates notable conservation of required factors between dipteran and human hosts. This work suggests new approaches to control infection in the insect vector and the mammalian host...
  52. pmc Population dynamics of Aedes aegypti and dengue as influenced by weather and human behavior in San Juan, Puerto Rico
    Roberto Barrera
    Entomology and Ecology Activity, Dengue Branch, Centers for Disease Control and Prevention, Calle Cañada, San Juan, Puerto Rico
    PLoS Negl Trop Dis 5:e1378. 2011
    Previous studies on the influence of weather on Aedes aegypti dynamics in Puerto Rico suggested that rainfall was a significant driver of immature mosquito populations and dengue incidence, but mostly in the drier areas of the island...
  53. pmc Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes
    Minh Nguyen Nguyet
    Oxford University Clinical Research Unit, District 5, Ho Chi Minh City, Vietnam
    Proc Natl Acad Sci U S A 110:9072-7. 2013
    ..and virus variables associated with dengue virus (DENV) transmission from symptomatic dengue cases (n = 208) to Aedes aegypti mosquitoes during 407 independent exposure events was defined...
  54. pmc Open field release of genetically engineered sterile male Aedes aegypti in Malaysia
    Renaud Lacroix
    Oxitec Sendirian Berhad, Kuala Lumpur, Wilayah persekutuan, Malaysia
    PLoS ONE 7:e42771. 2012
    ..In the absence of specific drugs or vaccines, control focuses on suppressing the principal mosquito vector, Aedes aegypti, yet current methods have not proven adequate to control the disease...
  55. pmc The native Wolbachia symbionts limit transmission of dengue virus in Aedes albopictus
    Laurence Mousson
    Department of Virology, Arboviruses and Insect Vectors, Institut Pasteur, Paris, France
    PLoS Negl Trop Dis 6:e1989. 2012
    ..Both arboviral diseases are transmitted to humans by two main mosquito species, Aedes aegypti and Aedes albopictus. In the absence of the former, Ae...
  56. pmc Reduction of Aedes aegypti vector competence for dengue virus under large temperature fluctuations
    Lauren B Carrington
    Department of Entomology, University of California, Davis, CA95616, USA
    Am J Trop Med Hyg 88:689-97. 2013
    ..We investigated the effect of two daily fluctuating temperature profiles on Aedes aegypti vector competence for dengue virus (DENV) serotype-1. A large diurnal temperature range of 18...
  57. pmc An evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense
    Jayme A Souza-Neto
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, The Johns Hopkins University, 615 North Wolfe Street E4209, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:17841-6. 2009
    ..Dengue virus infection in Aedes aegypti mosquitoes activates the JAK-STAT immune signaling pathway...
  58. ncbi Large diurnal temperature fluctuations negatively influence Aedes aegypti (Diptera: Culicidae) life-history traits
    Lauren B Carrington
    Department of Entomology, University of California Davis, CA, USA
    J Med Entomol 50:43-51. 2013
    ..fluctuations negatively influence epidemiologically important life-history traits of the primary dengue vector, Aedes aegypti (L.), compared with a constant 26 degrees C temperature...
  59. ncbi Lower survival rate, longevity and fecundity of Aedes aegypti (Diptera: Culicidae) females orally challenged with dengue virus serotype 2
    R Maciel-de-Freitas
    Laboratório de Transmissores de Hematozoários, Instituto Oswaldo Cruz, FIOCRUZ, Avenida Brasil 4365, 21040 360, Rio de Janeiro, RJ, Brazil
    Trans R Soc Trop Med Hyg 105:452-8. 2011
    ..its epidemiology, we compared the life-histories of dengue virus serotype 2 (DENV-2)-infected and uninfected Aedes aegypti females...
  60. pmc Alterations in the Aedes aegypti transcriptome during infection with West Nile, dengue and yellow fever viruses
    Tonya M Colpitts
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 7:e1002189. 2011
    ..Here, we present a microarray analysis of the Aedes aegypti transcriptome over time during infection with DENV, WNV or YFV...
  61. pmc Larval environmental temperature and the susceptibility of Aedes albopictus Skuse (Diptera: Culicidae) to Chikungunya virus
    Catherine J Westbrook
    Florida Medical Entomology Laboratory, Department of Entomology and Nematology, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, Florida 32962, USA
    Vector Borne Zoonotic Dis 10:241-7. 2010
    ..recent widespread epidemic of the mosquito-borne alphavirus chikungunya virus (CHIKV) was the important role of Aedes albopictus, formerly regarded as a secondary vector, compared to the presumed primary vector Aedes aegypti. Ae...
  62. pmc Dengue infection increases the locomotor activity of Aedes aegypti females
    Tamara N Lima-Camara
    Laboratório de Biologia Molecular de Insetos, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
    PLoS ONE 6:e17690. 2011
    b>Aedes aegypti is the main vector of the virus causing Dengue fever, a disease that has increased dramatically in importance in recent decades, affecting many tropical and sub-tropical areas of the globe...
  63. pmc Evidence of simultaneous circulation of West Nile and Usutu viruses in mosquitoes sampled in Emilia-Romagna region (Italy) in 2009
    Mattia Calzolari
    Istituto Zooprofilattico Sperimentale della Lombardia e dell Emilia Romagna B Ubertini IZSLER, Brescia, Italy
    PLoS ONE 5:e14324. 2010
    ..An extensive entomological survey was performed in 2009 to establish the presence and distribution of mosquito arboviruses in this region, with particular reference to flaviviruses...
  64. pmc Persistent Wolbachia and cultivable bacteria infection in the reproductive and somatic tissues of the mosquito vector Aedes albopictus
    Karima Zouache
    Universite de Lyon, Lyon, France
    PLoS ONE 4:e6388. 2009
    ..This study investigated Wolbachia and cultivable bacteria that persist through generations in Ae. albopictus organs known to host transmitted arboviruses, such as dengue and chikungunya...
  65. pmc Identification of microRNAs expressed in two mosquito vectors, Aedes albopictus and Culex quinquefasciatus
    Rebecca L Skalsky
    Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, NC 27710, USA
    BMC Genomics 11:119. 2010
    ..West Nile virus (WNV) and dengue virus, members of the Flaviviridae family, are primarily transmitted by Aedes and Culex mosquitoes. Using high-throughput deep sequencing, we examined the miRNA repertoire in Ae...
  66. ncbi Assessing the effects of temperature on the population of Aedes aegypti, the vector of dengue
    H M Yang
    UNICAMP IMECC, Departamento de Matematica Aplicada, Campinas, SP, Brazil
    Epidemiol Infect 137:1188-202. 2009
    Dengue is a vector-borne disease transmitted by the mosquito Aedes aegypti. The incidence of dengue disease shows a clear dependence on seasonal variation...
  67. ncbi Aedes albopictus, an arbovirus vector: from the darkness to the light
    C Paupy
    Institut de Recherche pour le Developpement, UR016, BP 1857 Yaoundé, Cameroon
    Microbes Infect 11:1177-85. 2009
    The Asian tiger mosquito, Aedes albopictus (Skuse, 1894), is an invasive species that can be found on all continents...
  68. ncbi Flavivirus susceptibility in Aedes aegypti
    William C Black
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Arch Med Res 33:379-88. 2002
    b>Aedes aegypti is the primary vector of yellow fever (YF) and dengue fever (DF) flaviviruses worldwide...
  69. pmc The relative importance of innate immune priming in Wolbachia-mediated dengue interference
    Edwige Rancès
    School of Biological Sciences, Monash University, Clayton, Australia
    PLoS Pathog 8:e1002548. 2012
    ..originally from Drosophila melanogaster, have been stably introduced into the mosquito vector of dengue fever, Aedes aegypti...
  70. ncbi Re-emergence of Chikungunya and O'nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships
    A M Powers
    Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0609, USA
    J Gen Virol 81:471-9. 2000
    ..differences in their transmission cycles: in Asia, the virus appears to be maintained in an urban cycle with Aedes aegypti mosquito vectors, while CHIK virus transmission in Africa involves a sylvatic cycle, primarily with AE: ..
  71. pmc Comparison of dengue virus type 2-specific small RNAs from RNA interference-competent and -incompetent mosquito cells
    Jaclyn C Scott
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA
    PLoS Negl Trop Dis 4:e848. 2010
    ..technology, we characterized dengue virus type 2 (DENV2)-specific small RNAs produced during infection of Aedes aegypti mosquitoes and A...
  72. pmc Spatial evaluation and modeling of Dengue seroprevalence and vector density in Rio de Janeiro, Brazil
    Nildimar Alves Honorio
    Laboratório de Transmissores de Hematozoários, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brasil
    PLoS Negl Trop Dis 3:e545. 2009
    ..peak of dengue transmission, we were also able to identify recent dengue infections and visually relate them to Aedes aegypti spatial distribution abundance...
  73. pmc Dengue virus type 2: replication and tropisms in orally infected Aedes aegypti mosquitoes
    Ma Isabel Salazar
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523 1692, USA
    BMC Microbiol 7:9. 2007
    ..Here we document the virogenesis of DENV-2 in newly-colonized Aedes aegypti mosquitoes from Chetumal, Mexico in order to understand better the effect of vector-virus interactions on ..
  74. pmc Sequential adaptive mutations enhance efficient vector switching by Chikungunya virus and its epidemic emergence
    Konstantin A Tsetsarkin
    Institute for Human Infections and Immunity, Center for Tropical Diseases, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS Pathog 7:e1002412. 2011
    The adaptation of Chikungunya virus (CHIKV) to a new vector, the Aedes albopictus mosquito, is a major factor contributing to its ongoing re-emergence in a series of large-scale epidemics of arthritic disease in many parts of the world ..
  75. pmc Molecular genetic analysis of midgut serine proteases in Aedes aegypti mosquitoes
    Jun Isoe
    Department of Chemistry and Biochemistry, BioSciences West Room 518, University of Arizona, Tucson, AZ 85721, USA
    Insect Biochem Mol Biol 39:903-12. 2009
    ..Based on recent reports indicating that the mechanism and regulation of protein digestion in blood fed female Aedes aegypti mosquitoes is more complex than previously thought, we used a robust RNAi knockdown method to investigate ..
  76. pmc Defining challenges and proposing solutions for control of the virus vector Aedes aegypti
    Amy C Morrison
    Department of Entomology, University of California, Davis, Davis, California, United States of America
    PLoS Med 5:e68. 2008
  77. ncbi Cross-induction of detoxification genes by environmental xenobiotics and insecticides in the mosquito Aedes aegypti: impact on larval tolerance to chemical insecticides
    Rodolphe Poupardin
    Laboratoire d Ecologie Alpine, UMR CNRS Université Joseph Fourier 5553, Equipe Perturbations Environnementales et Xénobiotiques, Domaine Universitaire de Saint Martin d Hères 2233, rue de la piscine Bât D Biologie, BP 53, 38041 Grenoble Cedex 9, France
    Insect Biochem Mol Biol 38:540-51. 2008
    The effect of exposure of Aedes aegypti larvae to sub-lethal doses of the pyrethroid insecticide permethrin, the organophosphate temephos, the herbicide atrazine, the polycyclic aromatic hydrocarbon fluoranthene and the heavy metal ..
  78. pmc Conservation of indole responsive odorant receptors in mosquitoes reveals an ancient olfactory trait
    Jonathan D Bohbot
    Department of Biological Sciences and Pharmacology, Center for Molecular Neuroscience, Programs in Developmental Biology and Genetics, Institutes for Chemical Biology and Global Health, Vanderbilt University, Nashville, TN 37235, USA
    Chem Senses 36:149-60. 2011
    b>Aedes aegypti and Anopheles gambiae are among the best-characterized mosquito species within the Culicinae and Anophelinae mosquito clades which diverged ∼150 million years ago...
  79. pmc Chikungunya virus emergence is constrained in Asia by lineage-specific adaptive landscapes
    Konstantin A Tsetsarkin
    Institute for Human Infections and Immunity, Center for Tropical Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Proc Natl Acad Sci U S A 108:7872-7. 2011
    ..This replacement process is associated with adaptation of the invasive CHIKV strains to an atypical vector, the Aedes albopictus mosquito that is ubiquitously distributed in the region...
  80. pmc Blood meal-derived heme decreases ROS levels in the midgut of Aedes aegypti and allows proliferation of intestinal microbiota
    Jose Henrique M Oliveira
    Laboratório de Bioquímica de Artrópodes Hematófagos, Instituto de Bioquimica Medica, Programa de Biologia Molecular e Biotecnologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
    PLoS Pathog 7:e1001320. 2011
    ..that toxic reactive oxygen species (ROS) generated by epithelial cells control bacterial growth in the midgut of Aedes aegypti, the vector of Yellow fever and Dengue viruses...
  81. ncbi Identification of odorant-binding proteins of the yellow fever mosquito Aedes aegypti: genome annotation and comparative analyses
    J J Zhou
    Biological Chemistry Department, Rothamsted Research, Harpenden, UK
    Insect Mol Biol 17:147-63. 2008
    The yellow fever mosquito Aedes aegypti is an important human health pest which vectors yellow fever and dengue viruses...
  82. pmc Towards a semen proteome of the dengue vector mosquito: protein identification and potential functions
    Laura K Sirot
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA
    PLoS Negl Trop Dis 5:e989. 2011
    ..target since these proteins, in aggregate, modulate the reproduction and feeding patterns of the dengue vector, Aedes aegypti...
  83. ncbi Isolation and characterization of a new insect flavivirus from Aedes albopictus and Aedes flavopictus mosquitoes in Japan
    Keita Hoshino
    Department of Medical Entomology, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku, Tokyo 162 8640, Japan
    Virology 391:119-29. 2009
    We isolated a new flavivirus from Aedes albopictus mosquito and a related species in Japan. The virus, designated Aedes flavivirus (AEFV), only replicated in a mosquito cell line and produced a mild cytopathic effect...
  84. pmc Induction of a peptide with activity against a broad spectrum of pathogens in the Aedes aegypti salivary gland, following Infection with Dengue Virus
    Natthanej Luplertlop
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Pathog 7:e1001252. 2011
    ..Virus (DENV) to man is strongly dependent on crosstalk between the virus and the immune system of its vector Aedes aegypti (Ae. aegypti)...
  85. pmc Oviposition site selection by the dengue vector Aedes aegypti and its implications for dengue control
    Jacklyn Wong
    Department of Entomology, University of California Davis, Davis, California, United States of America
    PLoS Negl Trop Dis 5:e1015. 2011
    Because no dengue vaccine or antiviral therapy is commercially available, controlling the primary mosquito vector, Aedes aegypti, is currently the only means to prevent dengue outbreaks. Traditional models of Ae...
  86. pmc Arbovirus-derived piRNAs exhibit a ping-pong signature in mosquito cells
    Nicolas Vodovar
    Institut Pasteur, Viruses and RNA interference Group and Centre National de la Recherche Scientifique URA 3015, Paris, France
    PLoS ONE 7:e30861. 2012
    ..Here, we report in cells derived from the two main vectors for arboviruses, Aedes albopictus and Aedes aegypti, the production of viral small RNAs that exhibit the hallmarks of ping-pong derived ..
  87. ncbi Blood-feeding and immunogenic Aedes aegypti saliva proteins
    Ladawan Wasinpiyamongkol
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Proteomics 10:1906-16. 2010
    ..We compared differential protein expression in the MGs and SGs of female Aedes aegypti mosquitoes after a sugar- or blood-based diet...
  88. pmc Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens
    Lyric C Bartholomay
    Department of Entomology, Iowa State University, Ames, IA 50011, USA
    Science 330:88-90. 2010
    ..quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W...
  89. ncbi Antibody response against saliva antigens of Anopheles gambiae and Aedes aegypti in travellers in tropical Africa
    Eve Orlandi-Pradines
    Unité de recherche en biologie et en épidémiologie parasitaires, Institut de Medecine Tropicale du Service de Sante des Armees, Parc le Pharo, BP 46, 13998 Marseille Armees, France
    Microbes Infect 9:1454-62. 2007
    ..The IgM and IgG antibody responses of 88 French soldiers against the saliva of Anopheles gambiae and Aedes aegypti were evaluated before and after a 5-month journey in tropical Africa...
  90. pmc Late-acting dominant lethal genetic systems and mosquito control
    Hoang Kim Phuc
    Department of Zoology, University of Oxford, South Parks Road, Oxford, UK
    BMC Biol 5:11. 2007
    ..Additionally, vector populations with strong density-dependent effects will tend to be resistant to SIT-based control as the population-reducing effect of induced sterility will tend to be offset by reduced density-dependent mortality...
  91. pmc Alphavirus-derived small RNAs modulate pathogenesis in disease vector mosquitoes
    Kevin M Myles
    Department of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Proc Natl Acad Sci U S A 105:19938-43. 2008
    ..We identified virus-derived small interfering RNAs (viRNAs), 21 nt in length, in Aedes aegypti infected with the mosquito-borne virus, Sindbis (SINV)...
  92. ncbi Comparative role of Aedes albopictus and Aedes aegypti in the emergence of Dengue and Chikungunya in central Africa
    Christophe Paupy
    Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale OCEAC, Yaounde, Cameroun
    Vector Borne Zoonotic Dis 10:259-66. 2010
    Since its discovery in Nigeria in 1991, Aedes albopictus has invaded much of Central Africa, a region where Ae. aegypti also occurs. To assess the relationship between the invasion by Ae...
  93. ncbi A mutation in the voltage-gated sodium channel gene associated with pyrethroid resistance in Latin American Aedes aegypti
    K Saavedra-Rodriguez
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA
    Insect Mol Biol 16:785-98. 2007
    ..Early detection of kdr is critical to the development of resistance management strategies in mosquitoes including Aedes aegypti, the most prevalent vector of dengue and yellow fever viruses. Brengues et al...
  94. pmc Global traffic and disease vector dispersal
    Andrew J Tatem
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
    Proc Natl Acad Sci U S A 103:6242-7. 2006
    ..Here we apply a coupled human-environment framework to describe the historical spread of Aedes albopictus, a competent mosquito vector of 22 arboviruses in the laboratory...
  95. pmc Small RNA profiling of Dengue virus-mosquito interactions implicates the PIWI RNA pathway in anti-viral defense
    Ann M Hess
    Department of Statistics, Colorado State University, Fort Collins, Colorado 80523, USA
    BMC Microbiol 11:45. 2011
    ..aegypti, we deep-sequenced small non-coding RNAs. Triplicate biological replicates were used so that rigorous statistical metrics could be applied...
  96. ncbi Temporal distribution of Aedes aegypti in different districts of Rio de Janeiro, Brazil, measured by two types of traps
    N A Honório
    Laboratório de Transmissores de Hematozoários, Instituto Oswaldo Cruz FIOCRUZ, Av Brasil 4365, Manguinhos, Rio de Janeiro, CEP 21045 900, Brasil
    J Med Entomol 46:1001-14. 2009
    ..This temporal pattern is generally attributed to the dynamics of its mosquito vector Aedes aegypti (L.). The objectives of this study were to characterize the temporal pattern of Ae...
  97. pmc Chikungunya virus and Aedes mosquitoes: saliva is infectious as soon as two days after oral infection
    Mathieu Dubrulle
    Institut Pasteur, Génétique Moléculaire des Bunyavirus, Paris, France
    PLoS ONE 4:e5895. 2009
    b>Aedes aegypti and Aedes albopictus are potential vectors of chikungunya virus (CHIKV)...
  98. pmc Molecular evolution of dengue viruses: contributions of phylogenetics to understanding the history and epidemiology of the preeminent arboviral disease
    Scott C Weaver
    Department of Pathology, Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Infect Genet Evol 9:523-40. 2009
    ..of DENV includes a sylvatic, enzootic cycle between nonhuman primates and arboreal mosquitoes of the genus Aedes, and an urban, endemic/epidemic cycle between Aedes aegypti, a mosquito with larval development in peridomestic ..
  99. pmc Exploring the molecular basis of insecticide resistance in the dengue vector Aedes aegypti: a case study in Martinique Island (French West Indies)
    Sebastien Marcombe
    Laboratoire de Lutte contre les Insectes Nuisibles LIN, Institut de Recherche Pour le Développement IRD Montpellier, France
    BMC Genomics 10:494. 2009
    The yellow fever mosquito Aedes aegypti is a major vector of dengue and hemorrhagic fevers, causing up to 100 million dengue infections every year...
  100. pmc Increased locomotor activity and metabolism of Aedes aegypti infected with a life-shortening strain of Wolbachia pipientis
    Oliver Evans
    School of Biological Sciences, The University of Queensland, St Lucia, Queensland, 4072, Australia
    J Exp Biol 212:1436-41. 2009
    ..that shortens insect lifespan has recently been transinfected into the primary mosquito vector of dengue virus, Aedes aegypti L...
  101. pmc Gene expression studies in mosquitoes
    Xiao Guang Chen
    Department of Parasitology, School of Public Health and Tropical Medicine, Southern Medical University, Guang Zhou, GD 510515, People s Republic of China
    Adv Genet 64:19-50. 2008
    ....

Research Grants75

  1. MAPPING OF FILARIAL VECTOR COMPETENCE IN AEDES AEGYPTI
    Dennis Knudson; Fiscal Year: 2002
    ..of discrete genome regions carrying genes determining the susceptibility of the yellow fever mosquito, Aedes aegypti, to several parasites including the filarial parasite responsible for zoonotic filariasis, dog heartworm, ..
  2. Analysis of the functions of axon guidance genes during vector mosquito developme
    MOLLY DUMAN SCHEEL; Fiscal Year: 2012
    ..These studies will include the yellow and dengue fever virus vector Aedes aegypti, as well as the malaria vector Anopheles gambiae...
  3. Molecular Physiology of the Epitrachael Endocrine System
    Michael E Adams; Fiscal Year: 2012
    ..or ablate specific peptidergic ensembles to test their necessary roles in the ecdysis sequence in Drosophila, Aedes, and Bombyx...
  4. VEE Virus Infection on the Mosquito Vector
    Scott C Weaver; Fiscal Year: 2013
    ..of most subtype IAB and IC epidemic strains also enhance their ability to infect the epidemic mosquito vector, Aedes (Ochlerotatus) taeniorhynchus, a salt marsh species that has been implicated in transmission during most major VEE ..
  5. Genetic Analysis of Mosquito Metamorphosis
    James T Nishiura; Fiscal Year: 2012
    ..These include the sequencing of the Anopheles gambiae[19], Aedes aegypti [20] and Culex pipiens genomes[21], developing techniques to produce stable transgenic mosquitoes [22-32], ..
  6. Characterization of the La Crosse Virus glycoprotein fusion peptide
    SAMANTHA STANDISH SOLDAN; Fiscal Year: 2012
    ..meningitis in areas of the Midwestern United States where its principal mosquito vector, Ochlerotatus (formerly Aedes) trisariatus, resides...
  7. Fitness and Virulence of Dengue Virus in the Context of Changing Host Immunity
    Eva Harris; Fiscal Year: 2012
    ..comparative genomics and then defined experimentally in relevant in vitro assays, established mouse models, and Aedes aegypti mosquitoes...
  8. Molecular genetic control of the immature female mosquito vector
    Helen Benes; Fiscal Year: 2012
    ..Recently, we isolated, from an Aedes atropalpus hexamerin gene (Hex-1...
  9. Disruption of Host-Seeking Behavior in Aedes and Culex Mosquitoes using Odorants
    Anandasankar Ray; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aedes aegypti mosquitoes transmit Dengue and Yellow Fever virus, and Culex quinquefasciatus mosquitoes transmit the West Nile virus and filarial parasite Wuchereria bancrofti to hundreds of millions ..
  10. Evaluation of the Effects of Chikungunya N-linked Glycosylation on Pathogenesis
    CHARLES EDWIN MCGEE; Fiscal Year: 2013
    ..public health concern;recently characterized genetic adaptation has allowed this virus to efficiently utilize Aedes albopictus mosquitoes, which are now distributed worldwide, as a primary transmission vector [1,2]...
  11. Systematic analysis of cell death regulation in mosquitoes
    Lei Zhou; Fiscal Year: 2009
    ..we identified and subsequently characterized the first RHG-like IAPantagonists, michelob_x (mx), in Anopheles and Aedes genomes...
  12. Mechanisms of sylvatic dengue emergence
    Scott C Weaver; Fiscal Year: 2011
    ..in West Africa and Malaysia, where they are transmitted among nonhuman primate reservoir hosts by arboreal Aedes spp. mosquitoes...
  13. Manipulation of stem cell activity and cell death by intracellular bacteria
    Horacio M Frydman; Fiscal Year: 2013
    ..melanogaster, Culex pipiens and Aedes aegypti. 2. Investigate the effect of infection on stem cell division with different Wolbachia strain-host species...
  14. New Alphavirus Expression Systems in Mosquitoes
    Kenneth E Olson; Fiscal Year: 2012
    ..sequence information and other bioinformatics are available for three major vector species (Anopheles gambiae, Aedes aegypti and Culex pipiens)...
  15. Development of an autodissemination station for control of mosquito vectors
    Yi Wang; Fiscal Year: 2012
    ..the feasibility of using autodissemination in a novel device for operational mosquito control against both Aedes albopictus and Aedes aegypti...
  16. Chimeric Alphavirus Vaccines for Chikungunya
    Scott C Weaver; Fiscal Year: 2010
    ..S., including temperate regions populated by the efficient vector, Aedes albopictus...
  17. Sustainable Control of Aedes aegypti and epidemic dengue
    Lars Eisen; Fiscal Year: 2013
    ..Current control measures used against the primary dengue virus (DENV) mosquito vector, Aedes aegypti, include source reduction to control juveniles and space spraying to control adults...
  18. PHYSIOLOGY OF INSECT AMINO ACID TRANSPORT
    Dmitri Y Boudko; Fiscal Year: 2010
    ..and analyze the impacts of pharmacogenetic NAT suppression in two model vector mosquitoes, Anopheles gambiae and Aedes aegypti...
  19. Environmental filters and medically important container mosquitoes
    Donald A Yee; Fiscal Year: 2011
    ..applicant): Water-filled containers harbor a community of specialist mosquitoes, with several species, including Aedes albopictus, A. triseriatus, and Culex quinquefasciatus, acting as vectors of important human diseases...
  20. Examination of Odorant Receptors in Vector Mosquitoes
    Laurence J Zwiebel; Fiscal Year: 2013
    ..cascade in the principal African malaria vector mosquito Anopheles gambiae sensu stricto and the arbovirus vector Aedes aegypti...
  21. Acoustic Behavior - Neural and Comparative Bases
    Ronald R Hoy; Fiscal Year: 2013
    ..The Aedes mosquito is not the smallest insect that hears...
  22. Developing Anti-viral Ribozymes to Suppress Arboviruses in Transgenic Mosquitoes
    Malcolm J Fraser; Fiscal Year: 2013
    ..They are transmitted to human populations by a single mosquito species, Aedes aegypti...
  23. Identification of bacteria-associated cues that regulate hatching of Aedes aegypt
    Loganathan Ponnusamy; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The mosquito Aedes aegypti is the primary vector of human viruses causing dengue and yellow fever, diseases of global public health importance...
  24. Arbovirus midgut escape mechanisms
    A Lorena Passarelli; Fiscal Year: 2013
    ..involved in midgut escape will be evaluated by RNA interference, arbovirus transducing systems, and transgenic Aedes aegypti mosquitoes by silencing or overexpressing target genes;and (3) the contribution of apoptosis and key ..
  25. Antiviral Pathways in Disease Vector Mosquitoes
    Zach N Adelman; Fiscal Year: 2013
    ..We have described the generation and validation of a transgenic strain of Aedes aegypti that "senses" the status of the RNAi pathway, through which we have shown that the genes Dcr-2 and Ago-2, ..
  26. Yellow Fever/Dengue Virus Competence in Aedes aegypt aegypti/formosus in Senegal
    William C Black; Fiscal Year: 2013
    b>Aedes aegypti sensu latu (s.l.) is the primary vector to humans of yellow fever virus (YFV) and the four serotypes of dengue virus (DENV1-4)...
  27. Biological vector control reducing arboviruses, including Dengue and Chikungunya
    JAMES WILLIAM MAINS; Fiscal Year: 2012
    ..effective control measures are not available against the invasive and medically important Asian Tiger Mosquito (Aedes albopictus)...
  28. Nitrogen Metabolism in Aedes Aegypti Mosquitoes
    PATRICIA YOLANDA SCARAFFIA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We have reported that Aedes aegypti female mosquitoes possess a remarkable biological system to survive toxic ammonia concentrations released by blood meal digestion using previously unknown metabolic ..
  29. Quasispecies dynamics in arbovirus persistence emergence and fitness
    GREGORY DAVID EBEL; Fiscal Year: 2013
    ..Field-collected and colonized Culex (main) and Aedes (secondary) mosquitoes will be assessed...
  30. Impacts of Urbanization on Vector Biology and Transmission of Dengue in China
    Xiaoguang Chen; Fiscal Year: 2013
    ..hypothesis that environmental changes resulting from urbanization affect the biology and vectorial capacity of Aedes albopictus, the major Dengue vector in southern China...
  31. The Burden of Chikungunya and Dengue Transmission, Infection and Disease in Kenya
    Angelle Desiree LaBeaud; Fiscal Year: 2013
    ..their relative contribution to acute febrile illness;2) Measure the level of CHIKV and DENV1- 4 circulation in Aedes mosquito vectors and estimate the amount of human-vector contact in Kenya;and 3) Detect and predict spatial and ..
  32. The Neuropeptide Control of Mosquito Host-Seeking Behavior
    Jeff Liesch; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aedes aegypti mosquitoes are the principal vectors for several human diseases including Dengue Fever, which generates ~50 million cases per year and places 2.5 billion people at risk (17)...
  33. Improving Robustness of a Tactical Model of Aedes/Dengue Dynamics
    Fred Gould; Fiscal Year: 2013
    ..The principal vector of dengue virus is the mosquito, Aedes aegypti, that lives in close association with humans and feed on human blood...
  34. Antibody Based Therapeuticcs for Chikungunya Virus
    Michael S Diamond; Fiscal Year: 2013
    ..and has the potential to spread globally because of the distribution and abundance of its primary mosquito vector, Aedes aegypti...
  35. Recombination-mediated cassette exchange in Aedes aegypti mosquitoes
    Zach N Adelman; Fiscal Year: 2013
    ..their ability to resist intramolecular recombination i cis and promote RMCE in the embryos of the dengue vector Aedes aegypti and the malaria vector Anopheles gambiae;(2) generate transgenic docking strains based on the best ..
  36. LARVAL MOSQUITO FEEDING AND MICROBIAL INTERACTIONS
    Edward D Walker; Fiscal Year: 2013
    ..Although we have focused on the mosquito Aedes triseriatus and the invasive species Aedes japonicus into water-filled tree holes as a model ecosystem for study, ..
  37. On the Edge: Dengue and Climate
    Kacey C Ernst; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aedes aegypti mosquitoes are the primary vector for dengue, yellow fever and chikungunya. The vector is present in most urban communities stretching along the U.S...
  38. Receptors and Neurons Mediating Acid Taste in Drosophila
    ANUPAMA ARUN DAHANUKAR; Fiscal Year: 2013
    ..acid taste in Drosophila, and to identify neurophysiological responses to carboxylic acids in the mosquito, Aedes aegypti...
  39. Massively parallel sequencing of the diapause transcriptome in Aedes albopictus
    Christine Elsik; Fiscal Year: 2010
    The Asian tiger mosquito, Aedes albopictus (Skuse), is an important vector of dengue fever and also efficiently transmits yellow fever, chikungunya virus and several native North American arboviruses...
  40. Molecular Improvement of Bacterial Mosquito Larvicides
    Brian A Federici; Fiscal Year: 2013
    ..Combined, these studies will strengthen the basis for using larvicides as component of integrated vector management programs for controlling species belonging to the most important vector genera, namely, Anopheles, Aedes, and Culex.
  41. Juvenile Hormone Receptor in Flies and Mosquitoes
    Thomas G Wilson; Fiscal Year: 2010
    ..approach that will accomplish three specific aims: First, GCE from the well-studied disease vector mosquito Aedes aegypti and from D. melanogaster will be isolated and tested for high affinity JH binding...
  42. On the Edge: Aedes aegypti dynamics on the boundary of its natural range.
    Kacey C Ernst; Fiscal Year: 2011
    b>Aedes aegypti mosquitoes are the primary vector for dengue, yellow fever and chikungunya. The vector is present in most urban communities stretching along the U.S.-Mexico border yet dengue transmission has only been noted in two U.S...
  43. Use of cell phones for field data capture in a Dengue Decision Support System
    Saul Lozano Fuentes; Fiscal Year: 2010
    ..a subcontract to UAY will accompany SSY teams during field surveillance and control of the dengue virus vector Aedes aegypti and duplicate data captured by SSY on paper forms through electronic data capture using cell phones ..
  44. Cationic Amino Acid Transport in Mosquitoes
    Immo Alex Hansen; Fiscal Year: 2012
    ..characterization of the cationic amino acid (AA) translocation system in the fat body of the Yellow fever mosquito Aedes aegypti, the principle vector for Dengue fever...
  45. Targeting dengue in the mosquito with small molecules
    MARIANO A GARCIABLANCO; Fiscal Year: 2013
    ..innovative interdisciplinary approach to discover and develop small molecules (compounds) that can render the Aedes aegypti vector mosquito resistant to the virus and thereby incapable of transmitting disease...
  46. Multispecies competition, indirect effects, and invasion in mosquito communities
    STEVEN JULIANO; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Container-dwelling mosquitoes are medically important, with Aedes albopictus, Ochlerotatus triseriatus, Culex pipiens/quinquefasciatus, among others, acting as vectors of human diseases...
  47. Gap Junction-mediated Regulation of the V-type H+-ATPase in a Renal Epithelium
    Peter M Piermarini; Fiscal Year: 2012
    ..of the PI's on-going molecular and physiological studies of the renal (Malpighian) tubules of the mosquito Aedes aegypti, which are a valuable model for studying transepithelial transport that is powered exclusively by the ..
  48. Chromosome-based genome assembly for Culex quinquefasciatus
    Maria Sharakhova; Fiscal Year: 2013
    ..of advanced genome-based strategies for vector control, the genomes of the three major mosquito genera-Anopheles, Aedes, and Culex-were sequenced over the last decade. The genome assembly of Cx...
  49. Genetic tools for manipulation of mosquitoes
    Susan M Paskewitz; Fiscal Year: 2013
    ..studies document the persistence of plasmid DNA and reporter gene activity from the egg to the adult stage in both Aedes aegypti and Anopheles gambiae, following delivery of the plasmids to the staged females...
  50. ENDOCRINOLOGY OF MOSQUITO REPRODUCTION
    MICHAEL STRAND; Fiscal Year: 2013
    ..Our current award focuses on Aedes aegypti, which is the species we best understand how egg maturation is regulated...
  51. Physical mapping of Aedes aegypti genome
    Maria Sharakhova; Fiscal Year: 2011
    ..The yellow fever mosquito, Aedes aegypti, is the primary global vector for dengue virus transmission. Because of its epidemiological importance, Ae...
  52. Dispersal and Phylogeography of Aedes aegypti
    SABINE LOEW; Fiscal Year: 2009
    ..spatial distribution of genetic variation at mitochondrial and micro-satellite loci for the yellow fever mosquito, Aedes aegypti, in South Florida...
  53. Eradication of a Primary Filariasis Vector Population at an Endemic Field Site
    STEPHEN LEONARD DOBSON; Fiscal Year: 2010
    ..The biology of the primary mosquito vector, Aedes polynesiensis, has been blamed for MDA failure. Since mosquitoes are obligate vectors of W...
  54. Mosquitocidal Action of Bacillus thuringensis Toxins
    Sarjeet S Gill; Fiscal Year: 2013
    ..Importantly Cyt1Aa binds through Cry11A loop domains that are also involved in binding endogenous Aedes aegypti receptor proteins...
  55. Aedes anti-dengue immunity
    GEORGE DIMOPOULOS DIMOPOULOS; Fiscal Year: 2010
    ..goal of the PIs research is to elucidate, at the molecular level, the immune responses of the mosquito vector Aedes aegypti to infection with a range of viral pathogens, including those that could be used as agents for ..
  56. MOLECULAR BASIS OF ECDYSTEROID ACTION IN THE MOSQUITO
    ALEXANDER SIMEON RAIKHEL; Fiscal Year: 2013
    ..female reproduction;the juvenile hormone regulatory cascade governing the post-eclosion development of the Aedes aegypti female fat body (FB;the tissue essential for egg development) will be investigated by means of ..
  57. Mosquitocidal Avtive Clostridium Toxins
    Sarjeet Gill; Fiscal Year: 2007
    ..Similarly, this bacterium together with B. sphaericus has been used successfully against both Aedes and Culex in many developed and developing countries, thereby attenuating diseases, such as dengue and West Nile...
  58. Reproductive interference between invasive Aedes vectors
    Leon Philip Lounibos; Fiscal Year: 2012
    ..most important arboviral diseases, are transmitted to humans predominantly by the widespread invasive mosquitoes, Aedes aegypti and Aedes albopictus. Following its broad diaspora during the last three decades from Asia, A...
  59. POPULATION GENETICS OF AEDES AEGYPTI IN THE WEST INDIES
    David Severson; Fiscal Year: 1999
    ..is the increase in population after insecticide due to expansion of a resistant population or due to immigration from other sites. ..
  60. Biochemistry of Chorion Hardening in Mosquitoes
    Jianyong Li; Fiscal Year: 2005
    DESCRIPTION: Floodwater mosquitoes, such as Aedes aegypti, oviposit on substrates at the edge of water, and the eggs hatch only after being flooded following adequate rainfall...
  61. Training in Dengue Prevention and Control
    William C Black; Fiscal Year: 2013
    ..is to provide critical training in modern approaches for control of the dengue virus (DENV1-4) mosquito vector Aedes aegypti and subsequent prevention of epidemic dengue fever (DF) and Dengue Hemorrhagic Fever (DHF)...
  62. Functional Domains of Bacillus thuringiensis Endotoxins
    DONALD DEAN; Fiscal Year: 2007
    ..mechanism of action of several mosquitocidal proteins against key pestiferous mosquito species, Anopheles gambiae, Aedes aegypti and Culex quinquefaciatus. The main mosquitocidal toxins of interest are the toxins of B...
  63. Mechanisms of Enhanced Arbovirus Infection by Mosquito Saliva
    Kristen A Bernard; Fiscal Year: 2013
    ..Our preliminary studies have narrowed the possible candidates to two protein families found in Culex tarsalis and Aedes aegypti, but not in Anopheles gambiae...
  64. Invasive Aedes Mosquitoes and Dengue in Brazil
    Leon Philip Lounibos; Fiscal Year: 2010
    ..emerged as a serious health problem in the tropical Americas late in the 20th century following the resurgence of Aedes aegypti and the failure of an earlier eradication campaign to quash this invasive vector species...
  65. Characterization of amino acid transport- and signaling in the mosquito fat body
    Immo Alex Hansen; Fiscal Year: 2013
    ..questions regarding nutrient transport and signaling pathways in the fat body of the yellow fever mosquito, Aedes aegypti...
  66. Development of a Yellow Fever Vaccine for Vulnerable Populations
    Ian Amanna; Fiscal Year: 2009
    ..Although YFV is typically spread by the bite of Aedes aegypti mosquitoes, it also represents a viral encephalitide with potential for use as a bioterrorism agent ..
  67. An epithelial model for V-type H+-ATPase-driven acid-base transport
    Peter M Piermarini; Fiscal Year: 2010
    ..will explore the mechanisms of acid-base transport in the Malpighian (renal) tubules of the yellow-fever mosquito, Aedes aegypti...
  68. DENGUE CONTROL IN MOSQUITOES BY SINGLE CHAIN ANTIBODIES
    KENNETH OLSON; Fiscal Year: 1999
    ..The principal vector of DEN disease, Aedes aegypti, has spread throughout these tropical regions...
  69. CHITIN BIOSYNTHESIS AND THE MOSQUITO PERITROPHIC MATRIX
    Bruce Christensen; Fiscal Year: 2007
    ..is aimed at increasing our understanding of midgut chitin biosynthesis required for PM formation in the mosquito, Aedes aegypti...
  70. Technology for automated real-time counting and identification of adult mosquitoe
    PHILIPP KIRSCH; Fiscal Year: 2007
    ..baited traps, with or without light) or adult oviposition behaviour (Culex gravid traps, Aedes ovitraps)...
  71. Molecular Markers for Anopheles Gambiae Age Grading
    Guiyun Yan; Fiscal Year: 2009
    ..Recently, gene transcriptional profiles were found to be sensitive and reliable for age grading in Aedes aegypti. In order to adapt this new technique to An. gambiae, age-grading calibration models specifically for An...
  72. GENETIC DIFFERENTIATION IN AEDES ALBOPICIUS SUBGROUP
    KARAMJIT RAI; Fiscal Year: 1991
    b>Aedes albopictus in an important vector of dengue and dengue hemorrhagic fevers. From its presumed origin in southeast Asia, it has expanded its range from Madagascar to Hawaii...
  73. ENDOCRINOLOGY OF MOSQUITO REPRODUCTION
    ARDEN LEA; Fiscal Year: 1991
    This proposal focuses on the isolation and characterization of regulatory neuropeptides from heads of Aedes aegypti females...
  74. EPIDEMIC CHIKUNGUNYA VIRUS: MOSQUITO INFECTION DETERMINANTS
    Stephen Higgs; Fiscal Year: 2009
    ..The potential for secondary spread and establishment of a transmission cycle involving Aedes albopictus and Ae. aegypti is a credible threat and must be treated seriously (Pearson, 2006)...
  75. The Aedes aegypti Genome Project
    David Severson; Fiscal Year: 2003
    ..The mosquito Aedes aegypti is the primary vector. In addition, A...