ticks

Summary

Summary: Blood-sucking acarid parasites of the order Ixodida comprising two families: the softbacked ticks (ARGASIDAE) and hardbacked ticks (IXODIDAE). Ticks are larger than their relatives, the MITES. They penetrate the skin of their host by means of highly specialized, hooked mouth parts and feed on its blood. Ticks attack all groups of terrestrial vertebrates. In humans they are responsible for many TICK-BORNE DISEASES, including the transmission of ROCKY MOUNTAIN SPOTTED FEVER; TULAREMIA; BABESIOSIS; AFRICAN SWINE FEVER; and RELAPSING FEVER. (From Barnes, Invertebrate Zoology, 5th ed, pp543-44)

Top Publications

  1. ncbi Ticks and tick-borne diseases: a One Health perspective
    Filipe Dantas-Torres
    Department of Immunology, Aggeu Magalhães Research Centre, Oswaldo Cruz Foundation, 50670 420 Recife, Pernambuco, Brazil
    Trends Parasitol 28:437-46. 2012
  2. pmc The ecology of infectious disease: effects of host diversity and community composition on Lyme disease risk
    Kathleen LoGiudice
    Institute of Ecosystem Studies, Box AB, Millbrook, NY 12545, USA
    Proc Natl Acad Sci U S A 100:567-71. 2003
  3. ncbi The global importance of ticks
    F Jongejan
    Department of Parasitology and Tropical Veterinary Medicine, Faculty of Veterinary Medicine, Utrecht University, PO Box 80 165, 3508 TD Utrecht, The Netherlands
    Parasitology 129:S3-14. 2004
  4. pmc The role of saliva in tick feeding
    Ivo M B Francischetti
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda MD, USA
    Front Biosci (Landmark Ed) 14:2051-88. 2009
  5. ncbi Crimean-Congo haemorrhagic fever
    Onder Ergonul
    Ankara Numune Education and Research Hospital, Infectious Diseases and Clinical Microbiology Clinic, Ankara, Turkey
    Lancet Infect Dis 6:203-14. 2006
  6. pmc Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals
    Dorothee Grimm
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South Fourth Street, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 101:3142-7. 2004
  7. pmc Identification and characterization of Ixodes scapularis antigens that elicit tick immunity using yeast surface display
    Tim J Schuijt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e15926. 2011
  8. pmc Subolesin expression in response to pathogen infection in ticks
    Zorica Zivkovic
    Department of Infectious Diseases and Immunology, Utrecht Centre for Tick Borne Diseases, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL Utrecht, The Netherlands
    BMC Immunol 11:7. 2010
  9. ncbi Foci of tick-borne diseases in southwest Germany
    Rainer Oehme
    State Health Office Baden Wuerttemberg, Stuttgart, Germany
    Int J Med Microbiol 291:22-9. 2002
  10. ncbi Lyme disease-a tick-borne spirochetosis?
    W Burgdorfer
    Science 216:1317-9. 1982

Detail Information

Publications346 found, 100 shown here

  1. ncbi Ticks and tick-borne diseases: a One Health perspective
    Filipe Dantas-Torres
    Department of Immunology, Aggeu Magalhães Research Centre, Oswaldo Cruz Foundation, 50670 420 Recife, Pernambuco, Brazil
    Trends Parasitol 28:437-46. 2012
    ..difficult, because it requires the disruption of a complex transmission chain, involving vertebrate hosts and ticks, which interact in a constantly changing environment...
  2. pmc The ecology of infectious disease: effects of host diversity and community composition on Lyme disease risk
    Kathleen LoGiudice
    Institute of Ecosystem Studies, Box AB, Millbrook, NY 12545, USA
    Proc Natl Acad Sci U S A 100:567-71. 2003
    ..a novel function of vertebrate biodiversity, the buffering of human risk of exposure to Lyme-disease-bearing ticks. We tested the Dilution Effect model, which predicts that high species diversity in the community of tick hosts ..
  3. ncbi The global importance of ticks
    F Jongejan
    Department of Parasitology and Tropical Veterinary Medicine, Faculty of Veterinary Medicine, Utrecht University, PO Box 80 165, 3508 TD Utrecht, The Netherlands
    Parasitology 129:S3-14. 2004
    b>Ticks and tick-borne diseases affect animal and human health worldwide and are the cause of significant economic losses...
  4. pmc The role of saliva in tick feeding
    Ivo M B Francischetti
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda MD, USA
    Front Biosci (Landmark Ed) 14:2051-88. 2009
    When attempting to feed on their hosts, ticks face the problem of host hemostasis (the vertebrate mechanisms that prevent blood loss), inflammation (that can produce itching or pain and thus initiate defensive behavior on their hosts) ..
  5. ncbi Crimean-Congo haemorrhagic fever
    Onder Ergonul
    Ankara Numune Education and Research Hospital, Infectious Diseases and Clinical Microbiology Clinic, Ankara, Turkey
    Lancet Infect Dis 6:203-14. 2006
    ..medically important tickborne viral diseases, closely approximating the known global distribution of Hyalomma spp ticks. Human beings become infected through tick bites, by crushing infected ticks, after contact with a patient with ..
  6. pmc Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals
    Dorothee Grimm
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South Fourth Street, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 101:3142-7. 2004
    ..The induction of a spirochetal virulence factor preceding the time and host in which it is required demonstrates a developmental sequence for transmission of this arthropod-borne pathogen...
  7. pmc Identification and characterization of Ixodes scapularis antigens that elicit tick immunity using yeast surface display
    Tim J Schuijt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e15926. 2011
    Repeated exposure of rabbits and other animals to ticks results in acquired resistance or immunity to subsequent tick bites and is partially elicited by antibodies directed against tick antigens...
  8. pmc Subolesin expression in response to pathogen infection in ticks
    Zorica Zivkovic
    Department of Infectious Diseases and Immunology, Utrecht Centre for Tick Borne Diseases, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL Utrecht, The Netherlands
    BMC Immunol 11:7. 2010
    b>Ticks (Acari: Ixodidae) are vectors of pathogens worldwide that cause diseases in humans and animals. Ticks and pathogens have co-evolved molecular mechanisms that contribute to their mutual development and survival...
  9. ncbi Foci of tick-borne diseases in southwest Germany
    Rainer Oehme
    State Health Office Baden Wuerttemberg, Stuttgart, Germany
    Int J Med Microbiol 291:22-9. 2002
    ..genogroup E. phagocytophila). Furthermore 12,327 ticks (Ixodes ricinus) collected in various areas of B-W were analysed by PCR and genotyping for the prevalence of ..
  10. ncbi Lyme disease-a tick-borne spirochetosis?
    W Burgdorfer
    Science 216:1317-9. 1982
    ..may be long-lasting cutaneous lesions that appeared on New Zealand White rabbits 10 to 12 weeks after infected ticks fed on them...
  11. ncbi Ticks and tickborne bacterial diseases in humans: an emerging infectious threat
    P Parola
    , CNRS UMR 6020, , , Marseille, France
    Clin Infect Dis 32:897-928. 2001
    b>Ticks are currently considered to be second only to mosquitoes as vectors of human infectious diseases in the world...
  12. ncbi Transmission of tick-borne pathogens between co-feeding ticks: Milan Labuda's enduring paradigm
    Sarah E Randolph
    Department of Zoology, University of Oxford, Oxford, UK
    Ticks Tick Borne Dis 2:179-82. 2011
    ..tick feeding sites, bearing infective virions and providing a transport route for the virus between co-feeding ticks independent of a systemic viraemia...
  13. pmc Evaluation of the long-term efficacy and safety of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto®) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in Europe
    Dorothee Stanneck
    Bayer Animal Health GmbH BAH, Monheim, Germany
    Parasit Vectors 5:66. 2012
    ..Bayer AnimalHealth, Investigational Veterinary Product(IVP)) in dogs and cats naturally infested with fleas and/or ticks in comparison to a dimpylat collar ("Ungezieferband fuer Hunde/fuer Katzen", Beaphar, Control Product (CP)).
  14. pmc Tick salivary secretion as a source of antihemostatics
    Jindrich Chmelar
    Division of Vascular Inflammation, Diabetes and Kidney, Department of Medicine and Institute of Physiology, Technical University Dresden, 01307 Dresden, Germany
    J Proteomics 75:3842-54. 2012
    b>Ticks are mostly obligatory blood feeding ectoparasites that have an impact on human and animal health...
  15. pmc Efficacy of an imidacloprid/flumethrin collar against fleas, ticks, mites and lice on dogs
    Dorothee Stanneck
    Bayer HealthCare AG, Animal Health Division, 51368 Leverkusen, Germany
    Parasit Vectors 5:102. 2012
    ..of imidacloprid/flumethrin incorporated in a slow-release matrix collar, against infestations of dogs by fleas, ticks, mites and lice...
  16. pmc A novel approach, based on BLSOMs (Batch Learning Self-Organizing Maps), to the microbiome analysis of ticks
    Ryo Nakao
    Division of Collaboration and Education, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan
    ISME J 7:1003-15. 2013
    b>Ticks transmit a variety of viral, bacterial and protozoal pathogens, which are often zoonotic. The aim of this study was to identify diverse tick microbiomes, which may contain as-yet unidentified pathogens, using a metagenomic approach...
  17. pmc Detection and genetic characterization of relapsing fever spirochete Borrelia miyamotoi in Estonian ticks
    Julia Geller
    National Institute for Health Development, Tallinn, Estonia
    PLoS ONE 7:e51914. 2012
    During the years 2008-2010 I. ricinus and I. persulcatus ticks were collected from 64 sites in mainland Estonia and on the island Saaremaa. Presence of B. miyamotoi was found in 0.9% (23/2622) of ticks. The prevalence in I...
  18. pmc Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection
    Kit Tilly
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA
    Infect Immun 74:3554-64. 2006
    ..spirochete Borrelia burgdorferi during a unique point in its natural infection cycle, which alternates between ticks and small mammals. OspC is a major surface protein produced by B...
  19. ncbi Functional genomic studies of tick cells in response to infection with the cattle pathogen, Anaplasma marginale
    Jose De La Fuente
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    Genomics 90:712-22. 2007
    The coevolution of ticks and the pathogens that they transmit has ensured their mutual survival. In these studies, we used a functional genomics approach to characterize tick genes regulated in response to Anaplasma marginale infection...
  20. ncbi Host association of Borrelia burgdorferi sensu lato--the key role of host complement
    Klaus Kurtenbach
    Dept of Infectious Disease Epidemiology, Imperial College of Science, Technology and Medicine, St Mary s Campus, Norfolk Place, W2 1PG, London, UK
    Trends Microbiol 10:74-9. 2002
    ..We conclude that vertebrate hosts rather than tick species are the key to Lyme borreliosis spirochaete diversity...
  21. ncbi Exposed and concealed antigens as vaccine targets for controlling ticks and tick-borne diseases
    P A Nuttall
    Centre for Ecology and Hydrology, Oxford, UK
    Parasite Immunol 28:155-63. 2006
    ..With the proliferation of molecular techniques and their application to vaccine development, there are high hopes for new and effective antitick vaccines that also control tick-borne diseases...
  22. pmc Coxiella burnetii in humans and ticks in rural Senegal
    Oleg Mediannikov
    URMITE, UMR IRD 198 CNRS 6236, Mediterranean University, Medical Faculty, Marseille, France
    PLoS Negl Trop Dis 4:e654. 2010
    ..Q fever is a worldwide zoonotic disease caused by Coxiella burnetii. Epidemiologically, animals are considered reservoirs and humans incidental hosts...
  23. ncbi New insights into the machinery of blood digestion by ticks
    Daniel Sojka
    Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, Ceske Budejovice, CZ 370 05, Czech Republic
    Trends Parasitol 29:276-85. 2013
    Blood-protein digestion is a key physiological process providing essential nutrients for ticks and is a prerequisite for the transmission of tick-borne pathogens...
  24. pmc Ticks and associated pathogens collected from dogs and cats in Belgium
    Edwin Claerebout
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Parasit Vectors 6:183. 2013
    Although Ixodes spp. are the most common ticks in North-Western Europe, recent reports indicated an expanding geographical distribution of Dermacentor reticulatus in Western Europe. Recently, the establishment of a D...
  25. ncbi Ticks (acari: ixodoidea: argasidae, ixodidae) of China
    Ze Chen
    Hebei Normal University, Shijiazhuang, China
    Exp Appl Acarol 51:393-404. 2010
    ..Some well known ticks carrying and transmitting many infectious agents to man and domestic animals are also found in China...
  26. pmc Molecular interactions that enable movement of the Lyme disease agent from the tick gut into the hemolymph
    Lili Zhang
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 7:e1002079. 2011
    Borrelia burgdorferi, the causative agent of Lyme disease, is transmitted to humans by bite of Ixodes scapularis ticks. The mechanisms by which the bacterium is transmitted from vector to host are poorly understood...
  27. ncbi Introduced Siberian chipmunks are more heavily infested by ixodid ticks than are native bank voles in a suburban forest in France
    B Pisanu
    Museum national d histoire naturelle, Département Ecologie et Gestion de la Biodiversité, UMR 7204 CERSP, MNHN CNRS P6, 61 rue Buffon, CP 53, 75231 Paris Cedex 05, France
    Int J Parasitol 40:1277-83. 2010
    ..During a 4-year longitudinal study, we investigated factors that affected infestation by ixodid ticks on both introduced Siberian chipmunks Tamias sibiricus barberi and native bank voles Myodes glareolus in a ..
  28. pmc Conflict of interest: use of pyrethroids and amidines against tsetse and ticks in zoonotic sleeping sickness endemic areas of Uganda
    Kevin Bardosh
    Division of Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Parasit Vectors 6:204. 2013
    ..The private veterinary market is divided between products only effective against ticks (amidines) and those effective against both ticks and tsetse (pyrethroids)...
  29. ncbi Tick-borne infections in dogs-an emerging infectious threat
    Bruno Chomel
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Parasitol 179:294-301. 2011
    ....
  30. pmc An ecological approach to preventing human infection: vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle
    Jean I Tsao
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:18159-64. 2004
    ..Outer surface protein A vaccination significantly reduced the prevalence of B. burgdorferi in nymphal blacklegged ticks (Ixodes scapularis) collected at the sites the following year in both experiments...
  31. ncbi Ticks feeding on humans: a review of records on human-biting Ixodoidea with special reference to pathogen transmission
    A Estrada-Pena
    Departamento de Parasitologia, Facultad de Veterinaria, Miguel Servet, Zaragoza, Spain
    Exp Appl Acarol 23:685-715. 1999
    In this article, literature records of argasid and ixodid ticks feeding on humans worldwide are provided in view of increased awareness of risks associated with tick bites...
  32. pmc Babesia and its hosts: adaptation to long-lasting interactions as a way to achieve efficient transmission
    Alain Chauvin
    Ecole Nationale Veterinaire, UMR 1300 BioEpAR, ENVN, Atlanpole La Chantrerie, BP 40706, F 44307 Nantes Cedex 03, France
    Vet Res 40:37. 2009
    ..The molecular bases of these adaptations in vertebrate hosts are partially known but few of the tick-host interaction mechanisms have been elucidated...
  33. pmc Experimental infection of Amblyomma aureolatum ticks with Rickettsia rickettsii
    Marcelo B Labruna
    Faculty of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Emerg Infect Dis 17:829-34. 2011
    We experimentally infected Amblyomma aureolatum ticks with the bacterium Rickettsia rickettsii, the etiologic agent of Rocky Mountain spotted fever (RMSF). These ticks are a vector for RMSF in Brazil. R...
  34. ncbi Repellent activity of catmint, Nepeta cataria, and iridoid nepetalactone isomers against Afro-tropical mosquitoes, ixodid ticks and red poultry mites
    Michael A Birkett
    Biological Chemistry Department, Rothamsted Research, Harpenden, Hertfordshire, UK
    Phytochemistry 72:109-14. 2011
    ..e. unfractionated, Nepeta spp. oils offer potentially greater protection, due to the presence of both nepetalactone isomers and other components such as (E)-(1R,9S)-caryophyllene...
  35. pmc Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks
    J Ohnishi
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 98:670-5. 2001
    ..burgdorferi vlsE locus before and during the blood meal. In unfed ticks, the vlsE locus was stable and one predominant and two minor alleles were detected...
  36. ncbi A real-time RT-PCR method for the universal detection and identification of flaviviruses
    G Moureau
    Unite des Virus Emergents, Faculte de Medecine, Marseille, France
    Vector Borne Zoonotic Dis 7:467-77. 2007
    ....
  37. ncbi The tick protective antigen, 4D8, is a conserved protein involved in modulation of tick blood ingestion and reproduction
    Jose De La Fuente
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    Vaccine 24:4082-95. 2006
    ..The function of 4D8 was characterized by RNA interference (RNAi) in five tick species. After the ticks were allowed to feed, degeneration of gut, salivary glands and reproductive tissues was observed, and tick ..
  38. pmc Invasion and intracellular development of the human granulocytic ehrlichiosis agent in tick cell culture
    U G Munderloh
    Department of Entomology, University of Minnesota, St Paul, Minnesota 55108, USA
    J Clin Microbiol 37:2518-24. 1999
    ..These may become compacted into clumps where individual organisms are barely discernible. Whether these are part of an ehrlichia life cycle or are degenerating is unknown...
  39. ncbi Rickettsial agents in Egyptian ticks collected from domestic animals
    Amanda D Loftis
    Viral and Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Exp Appl Acarol 40:67-81. 2006
    To assess the presence of rickettsial pathogens in ticks from Egypt, we collected ticks from domestic and peridomestic animals between June 2002 and July 2003...
  40. pmc Prevalence of Lyme disease Borrelia spp. in ticks from migratory birds on the Japanese mainland
    F Ishiguro
    Fukui Prefectural Institute of Public Health, Fukui 910 8551, Japan
    Appl Environ Microbiol 66:982-6. 2000
    Borrelia sp. prevalence in ticks on migratory birds was surveyed in central Japan. In autumn, a total of 1,733 birds representing 40 species were examined for ticks...
  41. ncbi Endosymbiotic bacteria associated with nematodes, ticks and amoebae
    Mark Taylor
    Molecular and Biochemical Parasitology Group, Liverpool School of Tropical Medicine, Liverpool, UK
    FEMS Immunol Med Microbiol 64:21-31. 2012
    ....
  42. pmc Prevalence of tick-borne pathogens in Ixodes ricinus and Dermacentor reticulatus ticks from different geographical locations in Belarus
    Anna L Reye
    Institute of Immunology, Centre de Recherche Public de la Santé National Public Health Laboratory, Luxembourg, Luxembourg
    PLoS ONE 8:e54476. 2013
    Worldwide, ticks are important vectors of human and animal pathogens. Besides Lyme Borreliosis, a variety of other bacterial and protozoal tick-borne infections are of medical interest in Europe...
  43. ncbi Targeting arthropod subolesin/akirin for the development of a universal vaccine for control of vector infestations and pathogen transmission
    Jose De La Fuente
    Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ronda de Toledo s n, 13005 Ciudad Real, Spain jose
    Vet Parasitol 181:17-22. 2011
    ..However, further research is needed in critical areas towards achieving this goal...
  44. pmc Tick-borne zoonotic bacteria in wild and domestic small mammals in northern Spain
    J F Barandika
    NEIKER, Instituto Vasco de Investigación y Desarrollo Agrario, 48160 Derio Bizkaia, Spain
    Appl Environ Microbiol 73:6166-71. 2007
    ..3% of C. glareolus voles and 14.3% of S. coronatus shrews. All small mammals were negative for spotted fever group rickettsiae. These results highlight the relevance of small mammals as reservoirs of some zoonotic bacteria...
  45. ncbi Anti-tick vaccines
    P Willadsen
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, Queensland 4067, Australia
    Parasitology 129:S367-87. 2004
    ..showing that the existing products can make an important contribution to an integrated approach to the control of ticks in the field...
  46. ncbi Multiple causes of variable tick burdens on small-mammal hosts
    Jesse L Brunner
    Cary Institute of Ecosystem Studies, Millbrook, New York 12545, USA
    Ecology 89:2259-72. 2008
    Blood meals by blacklegged ticks (Ixodes scapularis) on vertebrate hosts serve to transmit the agents of several zoonotic diseases, including Lyme disease, human babesiosis, and human granulocytic anaplasmosis, between host and tick...
  47. pmc Nested PCR assay for detection of granulocytic ehrlichiae
    R F Massung
    National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 36:1090-5. 1998
    ..the assay to nonhuman samples demonstrated products amplified from template DNA extracted from Ixodes scapularis ticks collected in Rhode Island and from EDTA-blood specimens obtained from white-tailed deer in Maryland...
  48. pmc An insight into the salivary transcriptome and proteome of the soft tick and vector of epizootic bovine abortion, Ornithodoros coriaceus
    Ivo M B Francischetti
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892 8132, USA
    J Proteomics 71:493-512. 2008
    ..The resulting analysis helps to consolidate the classification of common proteins found in both soft and hard ticks, such as the lipocalins, Kunitz, cystatin, basic tail, hebraein, defensin, TIL domain, metalloprotease, 5'-..
  49. pmc Prevalence and diversity of Borrelia species in ticks that have bitten humans in Sweden
    Peter Wilhelmsson
    Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    J Clin Microbiol 48:4169-76. 2010
    ..we developed a Light Upon eXtension (LUX) real-time PCR assay that can detect and quantify Borrelia species in ticks that have fed on humans, and we applied the assay to 399 such ticks...
  50. pmc Salivating for knowledge: potential pharmacological agents in tick saliva
    Joppe W R Hovius
    Center for Experimental and Molecular Medicine, Department of Internal Medicine, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    PLoS Med 5:e43. 2008
  51. ncbi Biology of ticks
    John F Anderson
    The Connecticut Agricultural Experiment Station, New Haven, CT 06504, USA
    Infect Dis Clin North Am 22:195-215, v. 2008
    b>Ticks are among the most significant blood-sucking arthropods worldwide. They transmit various pathogens that can cause disease and death in people, domesticated animals, and wildlife...
  52. ncbi Ecology of rickettsia in South America
    Marcelo B Labruna
    Department of Preventive Veterinary Medicine and Animal Health, Faculty of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Ann N Y Acad Sci 1166:156-66. 2009
    ..2000, only three Rickettsia species were known in South America: (i) Rickettsia rickettsii, transmitted by the ticks Amblyomma cajennense, and Amblyomma aureolatum, reported in Colombia, Argentina, and Brazil, where it is the ..
  53. ncbi Tick-borne disease systems emerge from the shadows: the beauty lies in molecular detail, the message in epidemiology
    S E Randolph
    Department of Zoology, University of Oxford, South Parks Road, Oxford, UK
    Parasitology 136:1403-13. 2009
    ..studies have linked a few of them to saliva-assisted transmission of non-systemic infections between co-feeding ticks, the quantitative key to persistent cycles of the most significant tick-borne pathogen in Europe...
  54. ncbi Worldwide distribution and diversity of seabird ticks: implications for the ecology and epidemiology of tick-borne pathogens
    Muriel Dietrich
    Génétique et Evolution des Maladies Infectieuses, UMR 2724 CNRS IRD, Centre IRD, Montpellier, France
    Vector Borne Zoonotic Dis 11:453-70. 2011
    The ubiquity of ticks and their importance in the transmission of pathogens involved in human and livestock diseases are reflected by the growing number of studies focusing on tick ecology and the epidemiology of tick-borne pathogens...
  55. ncbi Genetic characterization of ticks from southwestern Romania by sequences of mitochondrial cox1 and nad5 genes
    Lidia Chitimia
    Department of Parasitology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong Province, 510642, People s Republic of China
    Exp Appl Acarol 52:305-11. 2010
    ..The pcox1 and pnad5 were amplified separately from individual ticks by PCR, sequenced and analyzed...
  56. ncbi Tick subolesin is an ortholog of the akirins described in insects and vertebrates
    Ruth C Galindo
    Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ronda de Toledo s n, 13005 Ciudad Real, Spain
    Dev Comp Immunol 33:612-7. 2009
    ..The effect of subolesin and akirin2 knockdown was compared in adult ticks and mice, respectively...
  57. ncbi Molecular detection of spotted fever group rickettsiae in ticks from Ethiopia and Chad
    Alessandra Mura
    Instituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy
    Trans R Soc Trop Med Hyg 102:945-9. 2008
    DNA extracted from 363 ticks collected in Ethiopia and 9 ticks collected in Chad, Africa were screened by PCR to detect DNA from spotted fever group rickettsiae. Fifteen ticks (4...
  58. pmc Transport of ixodid ticks and tick-borne pathogens by migratory birds
    Gunnar Hasle
    Department of Biology, University of Oslo, Blindern, Norway
    Front Cell Infect Microbiol 3:48. 2013
    Birds, particularly passerines, can be parasitized by Ixodid ticks, which may be infected with tick-borne pathogens, like Borrelia spp., Babesia spp., Anaplasma, Rickettsia/Coxiella, and tick-borne encephalitis virus...
  59. ncbi Incidence from coincidence: patterns of tick infestations on rodents facilitate transmission of tick-borne encephalitis virus
    S E Randolph
    Department of Zoology, University of Oxford, UK
    Parasitology 118:177-86. 1999
    ..Endemic cycles appear to depend on the transmission of non-systemic infections between ticks co-feeding on the same rodent hosts...
  60. ncbi A molecular and serologic survey of Ehrlichia canis, E. chaffeensis, and E. ewingii in dogs and ticks from Oklahoma
    G L Murphy
    Department of Anatomy, Pathology, and Pharmacology, College of Veterinary Medicine, Oklahoma State University, Stillwater 74078, USA
    Vet Parasitol 79:325-39. 1998
    ..of Ehrlichia canis, Ehrlichia chaffeensis, and Ehrlichia ewingii in blood samples of 65 dogs that harbored ticks from northcentral and northeastern Oklahoma. Dog blood samples were also examined for antibodies against E...
  61. pmc Molecular and antigenic comparison of Ehrlichia canis isolates from dogs, ticks, and a human in Venezuela
    A Unver
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210-1093, USA
    J Clin Microbiol 39:2788-93. 2001
    ..In the present study, we examined whether dogs and ticks are infected with E. canis in Venezuela and, if so, whether this is the same strain as the human isolate...
  62. pmc Pathogen prevalence in ticks collected from the vegetation and livestock in Nigeria
    Anna L Reye
    Institute of Immunology, Centre de Recherche Public de la Santé National Public Health Laboratory, Luxembourg, Luxembourg
    Appl Environ Microbiol 78:2562-8. 2012
    b>Ticks are important disease vectors that can cause considerable economic losses by affecting animal health and productivity, especially in tropical and subtropical regions...
  63. ncbi Tick-Encoded serine proteinase inhibitors (serpins); potential target antigens for tick vaccine development
    A Muleng
    Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Vet Med Sci 63:1063-9. 2001
    ....
  64. ncbi Beyond Lyme: aetiology of tick-borne human diseases with emphasis on the south-eastern United States
    E Y Stromdahl
    Army Institute of Public Health, US Army Public Health Command, Aberdeen Proving Ground, MD, USA
    Zoonoses Public Health 59:48-64. 2012
    ..on tick-pathogen systems in the eastern United States, and findings from Department of Defense investigations of ticks found biting military personnel, indicate that residents of the south-eastern United States are primarily at risk ..
  65. ncbi Anaplasma phagocytophilum in ticks from parks in the Emilia-Romagna region of northern Italy
    Sara Aureli
    Department of Veterinary Medical Sciences, Alma Mater Studiorum University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia, Bologna, Italy
    Vet Ital 48:413-23. 2012
    ..The aim of this study was to assess the prevalence and phylogenetic characterisation of Anaplasma phagocytophilum in ticks in three parks of the Emilia-Romagna region of northern Italy, an area in which no survey of this agent had ..
  66. ncbi Longitudinal field study on bovine Babesia spp. and Anaplasma phagocytophilum infections during a grazing season in Belgium
    Laetitia Lempereur
    Laboratory of Parasitology and Parasitic Diseases, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liege, 4000 Liege, Belgium
    Parasitol Res 110:1525-30. 2012
    ..8%, 77%, and 56.9%, respectively. A total of 805 Ixodes ricinus ticks were collected at the same time from both cattle (feeding ticks) and grazed pastures (questing ticks)...
  67. ncbi Evolution of the secondary structure of the rRNA internal transcribed spacer 2 (ITS2) in hard ticks (Ixodidae, Arthropoda)
    O Hlinka
    Department of Microbiology and Parasitology, and Institute for Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia
    Heredity (Edinb) 88:275-9. 2002
    ..We studied the secondary structure of ITS2 in species from each of the six main lineages of hard ticks (family Ixodidae)...
  68. ncbi Widespread dispersal of Borrelia burgdorferi-infected ticks collected from songbirds across Canada
    John D Scott
    Research Division, Lyme Disease Association of Ontario, Fergus, Ontario, Canada
    J Parasitol 98:49-59. 2012
    Millions of Lyme disease vector ticks are dispersed annually by songbirds across Canada, but often overlooked as the source of infection...
  69. ncbi Sequence characterization and expression patterns of two defensin-like antimicrobial peptides from the tick Haemaphysalis longicornis
    Jinlin Zhou
    Department of Frontier Veterinary Medicine, Kagoshima University, Korimoto 1 21 24, Kagoshima 890 0065, Japan
    Peptides 28:1304-10. 2007
    ....
  70. pmc Quantitative differences in salivary pathogen load during tick transmission underlie strain-specific variation in transmission efficiency of Anaplasma marginale
    Massaro W Ueti
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Infect Immun 77:70-5. 2009
    ..Maries strain replicated to a 10-fold-higher titer and that a significantly greater percentage of infected ticks secreted A...
  71. ncbi Molecular characterization of tick-virus interactions
    Patricia A Nuttall
    NERC Centre for Ecology and Hydrology, Maclean Building, Crowmarsh Gifford, Wallingford, OX108BB, United Kingdom
    Front Biosci (Landmark Ed) 14:2466-83. 2009
    All viruses infecting ticks (with one possible exception) are arboviruses; their life cycle depends on infection and replication in both tick and vertebrate host cells...
  72. ncbi The feasibility of developing a risk assessment for the impact of climate change on the emergence of Crimean-Congo haemorrhagic fever in livestock in Europe: a review
    P Gale
    Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, Surrey, UK
    J Appl Microbiol 108:1859-70. 2010
    ..haemorrhagic fever virus (CCHFV) is one of the most widespread of all medically important arboviruses with ticks of the Hyalomma spp. serving as the main vectors...
  73. pmc Transformation of Anaplasma marginale
    Roderick F Felsheim
    Department of Entomology, University of Minnesota, St Paul, MN 55108, USA
    Vet Parasitol 167:167-74. 2010
    The tick-borne pathogen, Anaplasma marginale, has a complex life cycle involving ruminants and ixodid ticks. It causes bovine anaplasmosis, a disease with significant economic impact on cattle farming worldwide...
  74. pmc Nuttalliella namaqua: a living fossil and closest relative to the ancestral tick lineage: implications for the evolution of blood-feeding in ticks
    Ben J Mans
    Parasites, Vectors and Vector Borne Diseases, Agricultural Research Council Onderstepoort Veterinary Institute, Onderstepoort, South Africa
    PLoS ONE 6:e23675. 2011
    b>Ticks are monophyletic and composed of the hard (Ixodidae) and soft (Argasidae) tick families, as well as the Nuttalliellidae, a family with a single species, Nuttalliella namaqua...
  75. pmc Babesia spp. and Anaplasma phagocytophilum in questing ticks, ticks parasitizing rodents and the parasitized rodents--analyzing the host-pathogen-vector interface in a metropolitan area
    Cornelia Silaghi
    Comparative Tropical Medicine and Parasitology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Parasit Vectors 5:191. 2012
    ..and Anaplasma phagocytophilum in restored areas in both questing and host-attached Ixodes ricinus and Dermacentor reticulatus and their small mammalian hosts...
  76. ncbi Biological control of ticks
    M Samish
    Dept of Parasitology, Kimron Veterinary Institute, P O Box 12, Bet Dagan 50250, Israel
    Parasitology 129:S389-403. 2004
    b>Ticks have numerous natural enemies, but only a few species have been evaluated as tick biocontrol agents (BCAs)...
  77. ncbi Gene regulation in Borrelia burgdorferi
    D Scott Samuels
    Division of Biological Sciences and Biochemistry Program, The University of Montana, Missoula, Montana 59812, USA
    Annu Rev Microbiol 65:479-99. 2011
    ..B. burgdorferi also has a c-di-GMP signaling system that regulates the tick side of the enzootic cycle and whose function is only beginning to be appreciated...
  78. pmc Detection and identification of Ehrlichia spp. in ticks collected in Tunisia and Morocco
    M hammed Sarih
    Laboratoire des Spirochètes, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Clin Microbiol 43:1127-32. 2005
    ..by partial sequencing of the 16S rRNA gene was used for the detection of members of the family Anaplasmataceae in ticks in North Africa...
  79. ncbi Flea and tick control in the 21st century: challenges and opportunities
    Michael Wayne Dryden
    Department of Diagnostic Medicine Pathobiology, Kansas State University, Manhattan, KS 66506, USA
    Vet Dermatol 20:435-40. 2009
    ..Controlling tick infestations is important not only because ticks are nuisance parasites of dogs and cats, but also because they are vectors of a variety of bacterial and protozoal ..
  80. pmc Warmer weather linked to tick attack and emergence of severe rickettsioses
    Philippe Parola
    Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes, CNRS IRD UMR 6236, WHO Collaborative Centre for Rickettsial and Other Arthropod Borne Bacterial Diseases, Faculte de Medecine, Marseille, France
    PLoS Negl Trop Dis 2:e338. 2008
    ..sanguineus, leading to increased human attacks. From a global perspective, we predict that as a result of globalisation and warming, more pathogens transmitted by the brown dog tick may emerge in the future...
  81. pmc Isolation, cloning and structural characterisation of boophilin, a multifunctional Kunitz-type proteinase inhibitor from the cattle tick
    Sandra Macedo-Ribeiro
    Centro de Neurociências e Biologia Celular CNC, Coimbra, Portugal
    PLoS ONE 3:e1624. 2008
    ..This finding explains the formation of a ternary thrombin.boophilin.trypsin complex, and suggests a mechanism for prothrombinase inhibition in vivo...
  82. ncbi Vaccination against ticks (Boophilus spp.): the experience with the Bm86-based vaccine Gavac
    J de la Fuente
    Division of Mammalian Cell Genetics, Centro de Ingenieria Genetica y Biotecnologia, Havana, Cuba
    Genet Anal 15:143-8. 1999
    ..4 dollars animal(-1) year (-1). These results clearly demonstrate the advantage of vaccination and support the application of Gavac for the control of Boophilus spp. infestations...
  83. pmc Essential role of the response regulator Rrp2 in the infectious cycle of Borrelia burgdorferi
    Bethany K Boardman
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Infect Immun 76:3844-53. 2008
    ..transcription was unable to establish infection in mice, but the rrp2 mutant was capable of surviving within ticks during and after tick feeding...
  84. ncbi Tick-borne encephalitis
    Lars Lindquist
    Department of Medicine and Clinic for Infectious Diseases, Karolinska Institute, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Lancet 371:1861-71. 2008
    ..Tick-borne encephalitis virus is a flavivirus that is transmitted by Ixodes spp ticks in a vast area from western Europe to the eastern coast of Japan...
  85. pmc Ehrlichia chaffeensis expresses macrophage- and tick cell-specific 28-kilodalton outer membrane proteins
    Vijayakrishna Singu
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, KS 66506, USA
    Infect Immun 73:79-87. 2005
    ..Host cell-specific protein expression coupled with posttranslational modifications may be a hallmark for the pathogen's adaptation to a dual-host life cycle and its persistence...
  86. pmc An insight into the sialotranscriptome of the brown dog tick, Rhipicephalus sanguineus
    Elen Anatriello
    Department of Maternal and Child and Public Health Nursing, Ribeirao Preto School of Nursing, University of Sao Paulo, Ribeirao Preto, SP 14049 900, Brazil
    BMC Genomics 11:450. 2010
    ..tags (EST) from two cDNA libraries, one consctructed using mRNA from dissected salivary glands from female ticks fed for 3-5 days (early to mid library, RsSGL1) and the another from ticks fed for 5 days (mid library, RsSGL2), ..
  87. ncbi Tick- and flea-borne rickettsial emerging zoonoses
    Philippe Parola
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 5, France
    Vet Res 36:469-92. 2005
    ..Six of these species had first been isolated from ticks and later found to be pathogenic to humans...
  88. pmc Rickettsia monacensis sp. nov., a spotted fever group Rickettsia, from ticks (Ixodes ricinus) collected in a European city park
    Jason A Simser
    Department of Entomology, University of Minnesota, St Paul, Minnesota 55108, USA
    Appl Environ Microbiol 68:4559-66. 2002
    ..R. monacensis also replicated in cell lines derived from the ticks I...
  89. ncbi Mitochondrial gene order is not conserved in arthropods: prostriate and metastriate tick mitochondrial genomes
    W C Black
    Department of Microbiology, Colorado State University, Fort Collins 80523, USA
    Mol Biol Evol 15:1772-85. 1998
    ..Both genomes encode 22 tRNAs, 13 proteins, and two ribosomal RNAs. Prostriate ticks are basal members of Ixodidae and have the same gene order as Limulus polyphemus. In contrast, in R...
  90. ncbi Borrelia lonestari infection after a bite by an Amblyomma americanum tick
    A M James
    Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522-2087, USA
    J Infect Dis 183:1810-4. 2001
    ..rashes that are suggestive of early Lyme disease have been associated with the bite of Amblyomma americanum ticks, particularly in the southern United States...
  91. pmc Tick saliva is a potent inhibitor of endothelial cell proliferation and angiogenesis
    Ivo M B Francischetti
    Vector Biology Section, LMVR, NIAID, NIH, 12735 Twinbrook Parkway Twinbrook III, Room 2E28, Rockville, MD 20892 8132, USA
    Thromb Haemost 94:167-74. 2005
    ..tick saliva is a negative modulator of angiogenesis-dependent wound healing and tissue repair, therefore allowing ticks to feed for days...
  92. pmc Comparative genomics of emerging human ehrlichiosis agents
    Julie C Dunning Hotopp
    The Institute for Genomic Research, Rockville, Maryland, USA
    PLoS Genet 2:e21. 2006
    ..These discoveries provide significant insights into the biology of these obligate intracellular pathogens...
  93. ncbi Exploring gaps in our knowledge on Lyme borreliosis spirochaetes--updates on complex heterogeneity, ecology, and pathogenicity
    Jan Franke
    Institute of Nutrition, Department of Food and Environmental Hygiene, Friedrich Schiller University, Dornburger Strasse 29, Jena, Germany
    Ticks Tick Borne Dis 4:11-25. 2013
    ..Furthermore, there is evidence that ticks, reservoir hosts, and patients can be coinfected with multiple Borrelia spp...
  94. ncbi Characterization of phagocytic hemocytes in Ornithodoros moubata (Acari: Ixodidae)
    N Inoue
    National Research Center for Protozoan Diseases, Obihiro University, Hokkaido, Japan
    J Med Entomol 38:514-9. 2001
    ..FBS altered phagocytic activity of granulocytes, and complement affected phagocytic activity of plasmatocytes. Ticks were inoculated with fluorescent polystyrene beads in combination with FBS or complement...
  95. ncbi The quest for a universal vaccine against ticks: cross-immunity insights
    Luís F Parizi
    Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Avenida Bento Gonçalves, 9500, Prédio 43421, Porto Alegre 91501 970, RS, Brazil
    Vet J 194:158-65. 2012
    As blood-sucking parasites, ticks inflict great damage to animals and humans in many parts of the world...
  96. pmc Matrix-assisted laser desorption ionization-time of flight mass spectrometry for rapid identification of tick vectors
    Amina Yssouf
    Aix Marseille Universite, Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes, UM63, CNRS 7278, IRD 198, INSERM 1095, WHO Collaborative Center for Rickettsioses and Other Arthropod Borne Bacterial Diseases, Faculte de Medecine, Marseille, France
    J Clin Microbiol 51:522-8. 2013
    A method for rapid species identification of ticks may help clinicians predict the disease outcomes of patients with tick bites and may inform the decision as to whether to administer postexposure prophylactic antibiotic treatment...
  97. ncbi Ehrlichiosis and related infections
    Leah A Cohn
    College of Veterinary Medicine, University of Missouri Columbia, 379 East Campus, Clydesdale Hall, Columbia, MO 65211, USA
    Vet Clin North Am Small Anim Pract 33:863-84. 2003
    ..Ehrlichia and Anaplasma are transmitted largely through the bite of infected ticks, while vectors for Neorickettsia include trematodes and the intermediate hosts (i.e...
  98. ncbi Rickettsia parkeri as a paradigm for multiple causes of tick-borne spotted fever in the western hemisphere
    Christopher D Paddock
    Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Ann N Y Acad Sci 1063:315-26. 2005
    ..was generally considered as one of several "nonpathogenic" spotted fever group (SFG) rickettsiae that resided in ticks of the United States...
  99. ncbi Recurrent gains and losses of large (84-109 bp) repeats in the rDNA internal transcribed spacer 2 (ITS2) of rhipicephaline ticks
    A Murrell
    Department of Microbiology and Parasitology, Institute for Molecular Biosciences, University of Queensland, Brisbane 4072 Queensland, Australia
    Insect Mol Biol 10:587-96. 2001
    We studied the internal transcribed spacer 2 (ITS2) in twenty-two spp. of ticks from the subfamily Rhipicephalinae. A 104-109 base pair (bp) region was imperfectly repeated in most ticks studied...
  100. ncbi Plasmid requirements for infection of ticks by Borrelia burgdorferi
    Keith O Strother
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Vector Borne Zoonotic Dis 5:237-45. 2005
    ..Nymphal ticks were artificially fed the nine spirochete strains as well as the parental strain containing a full complement of ..
  101. pmc Hemocytic rickettsia-like organisms in ticks: serologic reactivity with antisera to Ehrlichiae and detection of DNA of agent of human granulocytic ehrlichiosis by PCR
    L A Magnarelli
    Department of Entomology, Connecticut Agricultural Experiment Station, New Haven 06504, USA
    J Clin Microbiol 33:2710-4. 1995
    Ixodid ticks were collected from Connecticut, Massachusetts, Missouri, Pennsylvania, Rhode Island, and British Columbia (Canada) during 1991 to 1994 to determine the prevalence of infection with hemocytic (blood cell), rickettsia-like ..

Research Grants73

  1. Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic Dis
    PATRICIA MASCARELLI; Fiscal Year: 2011
    ..As Bartonella spp. are transmitted by a large number of arthropod vectors, including fleas, lice, sand flies, ticks, biting flies and potentially others, determining the appropriate bacteria to screen for may be complicated by ..
  2. Systematics of medically important Dermacentor tick vectors
    Dmitry A Apanaskevich; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Ticks are obligate blood-feeders and temporary ectoparasites of terrestrial vertebrates...
  3. Biophysics of the morphology and motility of Borrelia burgdorferi in diverse envi
    Charles W Wolgemuth; Fiscal Year: 2013
    ..The bacterium transitions between the arthropod vector (Ixodid ticks) and mammalian host. This enzootic cycle requires the bacterium to interact with extremely different environments...
  4. Tick-Mammal Interface of Human Granulocytic Anaplasmosis
    ULRIKE GERTRUD MUNDERLOH; Fiscal Year: 2013
    ..prior funding period: 1) isolation of non-human-infectious Anaplasma phagocytophilum (Ap) from Camp Ripley, MN, ticks;2) stable transformation of Ap and identification of genes required for growth in tick or human cells;3) ..
  5. Tick Midgut Proteins Critical for Borrelia Transmission
    Sukanya Narasimhan; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Ixodes scapularis ticks transmit Borrelia burgdorferi (agent of Lyme disease), Anaplasma phagocytophilum (agent of human granulocytic ehrlichiosis) and Babesia microti (agent of human babesiosis) ..
  6. Molecular Physiology of the Epitrachael Endocrine System
    Michael E Adams; Fiscal Year: 2012
    ..studies also may provide basic new information about vector-borne human diseases involving mosquitoes, flies, ticks, and other arthropods...
  7. Symbiotic Rickettsia Species as a Model System for the Study of Folate Biosynthes
    Jianmin Zhong; Fiscal Year: 2012
    ..The metabolic basis for the symbiotic relationship of endosymbionts in ticks has been unknown...
  8. Tick feeding regulation by orthologous tick saliva serine protease inhibitors
    Albert Mulenga; Fiscal Year: 2013
    ..To complete feeding, ticks must overcome host defense reactions, blood coagulation, complement activation and inflammation, all of which are ..
  9. Development of a multivalent vaccine for mouse reservoirs of deer tick pathogens
    Linden T Hu; Fiscal Year: 2010
    Ixodes ticks serve as the vector for 3 human infections in the U.S.-- Lyme disease, Babesiosis and human granulocytic ehrlichiosis. The incidence of all three diseases has been increasing over the last decade...
  10. TYPE IV SECRETION &SIGNAL TRANSDUCTION IN EHRLICHIOSIS
    Yasuko Rikihisa; Fiscal Year: 2013
    ..These pathogens are fastidious obligatory intracellular bacteria that infect human leukocytes, and ticks are biological vectors for transmission...
  11. Virulence Determinants of Borrelia burgdorferi
    Steven J Norris; Fiscal Year: 2013
    ..by applicant): Borrelia burgdorferi is the causative agent of Lyme disease in North America and is transmitted by ticks of the genus Ixodes...
  12. Functional analysis of the Francisella capBCA gene locus
    Jing Ren Zhang; Fiscal Year: 2010
    ..There are no licensed vaccines against tularemia. F. tularensis can infect a wide range of host from ticks to humans. However, the mechanisms for this extreme versatility are unknown...
  13. RpoS Regulation of Borrelia burgdorferi Genes in vivo
    Justin D Radolf; Fiscal Year: 2013
    ..Bb is maintained in nature via an enzootic cycle that typically involves rodents and Ixodes ticks. To sustain this complex life cycle, Bb must continuously alter its transcriptome, proteome, and metabolome in ..
  14. Identification of bacterial genes required for transmission of tick-borne pathoge
    Susan M Noh; Fiscal Year: 2012
    ..research is to identify pathogen molecules required for colonization of and successful transmission by ixodid ticks. Pathogen transmission relies on the successful transition from the vertebrate host into the tick, which includes ..
  15. OspC regulation and pathogenic strategy of Borrelia burgdorferi
    Fang Ting Liang; Fiscal Year: 2013
    ..B. burgdorferi abundantly produces outer surface protein A (OspA) in engorged and flat ticks but downregulates OspA and upregulates OspC in response to a bloodmeal...
  16. Recognition of host catecholamines in Borrelia burgdorferi gene regulation
    Linden T Hu; Fiscal Year: 2010
    ..We have also been able to show that propranolol inhibits OspA expression in an in vivo model. B. burgdorferi from ticks that were fed on infected mice treated with propranolol expressed less OspA than those fed on mice administered ..
  17. The Role of Plasmids in Rickettsia Biology
    ULRIKE GERTRUD MUNDERLOH; Fiscal Year: 2013
    ..Many Rickettsia species are associated with blood-feeding arthropods (ticks, lice, fleas and mites) that serve as vectors for their transmission to vertebrate hosts...
  18. VIRULENCE-ASSOCIATED PROTEINS IN LYME DISEASE
    Steven J Norris; Fiscal Year: 2013
    ..and related organisms cause Lyme disease, a multistage, systemic infection that is transmitted by Ixodes ticks and has dermatologic, neurologic, arthralgic, and constitutional manifestations in humans and other animals...
  19. Determinants of Borrelia Diversity and Population Structure
    ELISABETH BAUM; Fiscal Year: 2010
    ..The agent is the spirochete Borrelia burgdorferi, which is transmitted by Ixodes scapularis ticks in the eastern U.S. A major reservoir for the infection is the mouse Peromyscus leucopus...
  20. Molecular basis for spotted fever group Rickettsia vector competence in ticks
    Kevin R Macaluso; Fiscal Year: 2013
    ..Our long term goal is to elucidate the molecular mechanisms that are central to rickettsial transmission by ticks. Despite the overlapping distribution of ticks with multiple Rickettsia species in nature, individual tick species ..
  21. Development of Paratransgenic ticks for Disease Control
    ULRIKE GERTRUD MUNDERLOH; Fiscal Year: 2013
    ..symbionts to express GFP, and their use as model organisms to track routes of dispersal of SFG rickettsiae within ticks;identification of a plasmid in these rickettsiae having sequence homology with the R...
  22. Virulence Determinants of Borrelia burgdorferi
    Steven J Norris; Fiscal Year: 2012
    ..by applicant): Borrelia burgdorferi is the causative agent of Lyme disease in North America and is transmitted by ticks of the genus Ixodes...
  23. Delineation of Borrelia burgdorferi motility and chemotaxis in the development of
    MD A MOTALEB; Fiscal Year: 2013
    ..disease is caused by the spirochetal bacteria Borrelia burgdorferi (Bb), which is transmitted to humans by Ixodes ticks. The disease is categorized as an emerging infectious disease and is the most prevalent vector borne disease in ..
  24. Interactions Between Anaplasma Phagocytophilum and Ixodes Scapularis
    Erol Fikrig; Fiscal Year: 2013
    ..In ticks Anaplasma induces I...
  25. Babesiosis Emergence in the United States
    MARIA ANA DIUK-WASSER; Fiscal Year: 2013
    ..Diuk- Wasser and collaborators that coinfected hosts produce more S. m/crof/-infected ticks than 6...
  26. Genetic Mechanisms in Borrelia burgdorferi Pathogenesis
    Jonathan T Skare; Fiscal Year: 2013
    ..The studies described herein are designed to address how B. burgdorferi is able to adapt to both ticks and mammals, in the context of host mediated oxidation defenses, and how this adaptive response affects the ..
  27. Immunologic mechanisms in post-Lyme disease syndrome
    Armin Alaedini; Fiscal Year: 2011
    ..a multisystem infection, caused by bacteria of the Borrelia burgdorferi species complex and transmitted by Ixodes ticks. The initial skin rash may be followed by complications affecting joints, heart, and the nervous system, all of ..
  28. Recombinant Subunit Vaccine for Tick-Borne Encephalitis
    David E Clements; Fiscal Year: 2011
    ..The infection is naturally transmitted via vector ticks in endemic areas. However, the highly infective viruses can also be transmitted via food or in aerosolized form...
  29. RpoS Regulation of Borrelia burgdorferi Genes in vivo
    Justin D Radolf; Fiscal Year: 2012
    ..Bb is maintained in nature via an enzootic cycle that typically involves rodents and Ixodes ticks. To sustain this complex life cycle, Bb must continuously alter its transcriptome, proteome, and metabolome in ..
  30. Molecular Mechanisms Regulating Early Stage Tick Feeding
    Albert Mulenga; Fiscal Year: 2012
    ..They are critical to understanding the acquisition and transmission of pathogens by ticks, which in turn will be important in designing novel approaches to control ticks and tick- borne diseases...
  31. Analysis of the Borrelia burgdorferi Integrin Ligand P66
    Jenifer L Coburn; Fiscal Year: 2013
    ..We generated B. burgdorferi p66- mutants, and showed that these mutants are not infectious in mice, but are in ticks. The p66 mutants are cultivable from the site of infection in mice for only 1-2 days, and are not infectious even ..
  32. Defining Microbial and Host Factors in Innate Immune Responses in Lyme Arthritis
    Klemen Strle; Fiscal Year: 2013
    ..burgdorferi genotype, RST1 (OspC Type A) which has been shown to have a high transmission frequency among ticks, and may be primarily responsible for the emergence of Lyme disease in epidemic form in the northeastern U.S...
  33. A Lyme disease vaccine using newly identified in-vivo expressed antigens
    Michel Ledizet; Fiscal Year: 2013
    ..Control measures designed to prevent contact with ticks are not sufficient to prevent the disease...
  34. Xenodiagnosis of Lyme Disease
    Linden T Hu; Fiscal Year: 2012
    ..bacteria can persist after treatment and are detectable by PCR or xenodiagnosis (the feeding of uninfected Ixodes ticks on the treated animals)...
  35. Serine Proteinase Inhibitors (Serpins) in Tick Feeding and Physiology
    Albert Mulenga; Fiscal Year: 2009
    In the United States (US) ticks transmit more vector borne disease agents than any other vector arthropod...
  36. Cellular processing and role of a surface antigen in borrelial pathogenesis
    Xiuli Yang; Fiscal Year: 2013
    ..The microbe survives in nature through an intricate enzootic cycle involving Ixodes ticks and mammals. During feeding, infected ticks can transmit B...
  37. Borrelia burgdorferi tick phase genes and Lyme disease pathogenesis
    IRA S SCHWARTZ; Fiscal Year: 2013
    ..burgdorferi growth and maintenance in ticks. In specific aim 3 we will perform global transcriptome analysis of B...
  38. BORRELIA BURGDORFERI INTERACTIONS WITH IXODES SCAPULARIS
    Erol Fikrig; Fiscal Year: 2012
    ..scapularis Salp15 during transmission from ticks, and that B. burgdorferi then use Salp15 to facilitate infection of mice...
  39. Coinfection by Rickettsiae in Amblyomma maculatum: Impact on Disease Transmission
    ANDREA SOARES VARELA-STOKES; Fiscal Year: 2013
    ..In fact, this tick-rickettsial system may differ from those previously described for Dermacentor ticks and SFGR...
  40. Overwintering mortality of nymphal Ixodes scapularis, Lyme disease vector, in a c
    RICHARD S contact OSTFELD; Fiscal Year: 2010
    ..been hypothesized that the cold, dry winter conditions of northern and interior environments kill overwintering ticks and thus limit the distribution of these vectors...
  41. Human pathogenic bacterium induces actin phosphorylation to selectively regulate
    Hameeda Sultana; Fiscal Year: 2012
    ..Pathogen use of the actin cytoskeleton in arthropod vectors has not yet been explored. Using Ixodes scapularis ticks and Anaplasma phagocytophilum (the agent of human granulocytic anaplasmosis) as an infection model, I provide ..
  42. Borella Gene Products Critical For Natural Infection Cycle
    Utpal Pal; Fiscal Year: 2013
    ..Second, we have discovered that BBA52 is critical for pathogen transmission from ticks to mice and that the protein binds to a receptor in ticks...
  43. Evolution of chronic infection in Anasplasma phagocytophilum
    Anthony F Barbet; Fiscal Year: 2010
    ..levels of natural selection due to immunity imposed by hosts, obligate drift imposed by transmission through ticks and hosts, and strategies of hyper-recombination utilized by the pathogens...
  44. VIRULENCE-ASSOCIATED PROTEINS IN LYME DISEASE
    Steven J Norris; Fiscal Year: 2010
    ..and related organisms cause Lyme disease, a multistage, systemic infection that is transmitted by Ixodes ticks and has dermatologic, neurologic, arthralgic, and constitutional manifestations in humans and other animals...
  45. Identifying Borrelia turicatae genes needed for colonization and transmission fro
    Job E Lopez; Fiscal Year: 2013
    ..provided by applicant): Relapsing fever spirochetosis is a global disease transmitted by argasid (soft-shelled) ticks or the human body louse...
  46. INTERSPECIFIC COMPETITION BETWEEN RICKETTSIAE IN TICKS
    Abdu F Azad; Fiscal Year: 2013
    ..of tick-borne spotted fever group rickettsiae both field and laboratory studies have demonstrated that while ticks are capable of acquiring multiple rickettsial infections most often tick surveys revealed the presence of only a ..
  47. Structural Biology of the S. elongatus Circadian Clock
    Martin Egli; Fiscal Year: 2013
    ..The high-resolution structures of these proteins suggest a racheting mechanism by which the KaiABC oscillator ticks unidirectionally...
  48. Role of fleas in transmission of rickettsiae: ecology of flea-borne spotted fever
    KEVIN MACALUSO; Fiscal Year: 2009
    ..Pathogenic Rickettsia are typically transmitted to humans by arthropods (insects and ticks)...
  49. Determining the reservoir hosts for host-targeted control measures to prevent Lym
    MARIA ANA DIUK WASSER; Fiscal Year: 2010
    ..upon humans for disease prevention, a more effective way to reduce LD risk is to decrease the number of infected ticks by reducing the prevalence of the pathogen in the wildlife reservoir hosts...
  50. First Transcriptome to the Tick Olfactory System
    RICHARD MICHAEL ROE; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Ticks are major vectors of human and animal diseases and a significant nuisance problem...
  51. Phylogeographic dynamics of a vector and pathogen in a natural environment
    Dustin Brisson; Fiscal Year: 2013
    ..bacterium Borrelia burgdorferi, affects more people than any other arthropod-borne disease (carried by insects or ticks) in the US. The number of human cases continues to rise as the geographic range affected by the bacteria expands...
  52. Culture and Identification of Rickettsia-like Organisms in Maryland
    Douglas E Norris; Fiscal Year: 2010
    ..Specific infection rates and the potential human pathogens with which these ticks are infected, are poorly documented, but could include several Rickettsia (NIAID Category C Priority Pathogens) ..
  53. Role of Vector antioxidant factors in Amblyomma-Rickettsia interaction
    Shahid Karim; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Ticks, and other blood-feeding arthropod vectors, manipulate host homeostatic responses by secreting molecules from their multifunctional salivary glands...
  54. A Multiplex Platform for Lyme Disease Diagnosis and Treatment Response
    Monica E Embers; Fiscal Year: 2013
    ..The etiologic agent, B. burgdorferi is transmitted to humans via Ixodes ticks and spreads hematogenously to cause a systemic disease...
  55. Francisella Infection in Ticks
    Dara W Frank; Fiscal Year: 2013
    ..These bacterial components may serve as novel targets for therapeutic or vaccine interventions. ..
  56. Defining Borrelia Genes Required for Tick Infection and Transmission
    Aravinda M de Silva; Fiscal Year: 2012
    ..Studies have demonstrated that spirochetes delivered by ticks express different antigens compared to cultured spirochetes...
  57. Causes and consequences of ospC variation in Borrelia burgdorferi to Lyme disease
    Dustin Brisson; Fiscal Year: 2011
    ..by the bacterium Borrelia burgdorferi, affects more people than any other arthropod-borne (carried by insects or ticks) disease in the US. However, humans cannot be infected by all B...
  58. IgE to carbohydrates causes delayed anaphylaxis
    SCOTT PALMER COMMINS; Fiscal Year: 2013
    ..90% of patients in our cohort who have IgE to alpha-gal report being bitten by large numbers of adult or larval ticks ('seed ticks') in the weeks or months prior to developing symptoms...
  59. Relapsing fever spirochete protein production within the vector
    Job E Lopez; Fiscal Year: 2013
    ..A method has been developed to cryopreserve and section ticks, clearly distinguishing spirochete populations within the midgut and salivary glands...
  60. 13th International Conference on Lyme Borreliosis and Other Tick-borne Diseases
    Linden T Hu; Fiscal Year: 2013
    ..1983, has become the premiere conference for showcasing research advances in human diseases transmitted by Ixodes ticks. The diseases included in this conference are Lyme borreliosis, babesiosis, human granulocytic anaplasmosis (..
  61. The Health Burden of A Recently Discovered Borrelia Spirochete
    PETER JAMES KRAUSE; Fiscal Year: 2012
    ..miyamotoi-infected Ixodes ticks are similar to those in the northeastern United States...
  62. Production of OspA in rice for the control of Lyme Disease
    Ning Huang; Fiscal Year: 2012
    ..burgdorferi from vector ticks, thereby suppressing enzootic transmission and preventing them from passing the disease to humans...
  63. Rickettsia ricketti and Rickettsia-like organisms in Maryland
    Douglas Norris; Fiscal Year: 2009
    ..This region also supports large populations of the three most common human-biting ticks in the eastern United States, Dermacentor variabilis, Amblyomma americanum and Ixodes scapularis. Although D...
  64. Coinfection of Tick-borne Diseases in Areas of Wisconsin
    DIANE CAPORALE; Fiscal Year: 2001
    ..Past deer surveys have suggested no existence of deer ticks in the eastern part of Wisconsin, except Marinette County near Green Bay...
  65. CHEMISTRY OF ARTHROPOD SECRETIONS
    Jerrold Meinwald; Fiscal Year: 2007
    ..e. tsetse fly, anopeheline mosquitoes, triatomine bugs, ticks ...), and some have developed into agricultural, forest, and household pests...
  66. The role of Borrelia burgdorferi chemotoxis in the pathogenesis of Lyme disease
    Md Motaleb; Fiscal Year: 2009
    ..The disease is caused by the spirochete Borrelia burgdorferi, which is transmitted to humans via infected Ixodes ticks. Lyme disease is a multiple systemic disorder with various clinical manifestations including erythema migrans, ..
  67. REPRODUCTION IN TICKS AND MITES
    James Oliver; Fiscal Year: 1993
    ..of this research is to understand more about productive mechanisms and their evolution in acarines (mites and ticks) and other ectoparasites vectors of public health importance which exhibit different parasitic habits and ticks ..
  68. MOLECULAR MECHANISMS OF MSP2 VARIATION IN RICKETTSIAE
    Anthony Barbet; Fiscal Year: 2007
    ..MSP2 was initially defined in Anaplasma marginale and infections of cattle and ticks with this pathogen provide an excellent model for discovering the mechanisms used to modify the surface proteome...
  69. Rapid Detection and Identification of Zoonotic Pathogens
    John Dunn; Fiscal Year: 2007
    ..catalysts that promoted epidemics of these ancient afflictions, which are normally transmitted by fleas, lice and ticks. Many of these diseases remain endemic in various regions of the world and therefore pose serious threats to U.S...
  70. Vaccination Against Ixodes scapularis Tick Bites
    Raymond Koski; Fiscal Year: 2001
    ..We have developed a guinea pig model of host immunity against ticks. The tick-sensitized guinea pigs do not acquire Lyme disease when challenged with B. burgdorferi-infected I....
  71. RISK OF TBE IN NORTH AMERICA FOCI OF LYME DISEASE
    Andrew Spielman; Fiscal Year: 1992
    ..divergens in vector ticks; (4) explore the possibility of using CR technology-for diagnosing these various infections in place of ..
  72. Nanoporous Gold: Extractive Substrate for High-Speed Ultrasensitive Bioassays
    Lorraine Siperko; Fiscal Year: 2010
    ..with infected individuals, ingestion of contaminated food and water, or contact with a vector like mosquitoes and ticks. These pathways, which may only need to transmit a few tens to hundreds of viruses to trigger an infection, will ..
  73. A Rickettsial Symbiont Model for the Control of Tick-borne Diseases
    Jianmin Zhong; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Ticks are the most important vector of many infectious diseases in the United States...