Summary: Animals that have no spinal column.

Top Publications

  1. ncbi TOR signaling in invertebrates
    Alexandre Soulard
    Biozentrum, University of Basel, Basel, Switzerland
    Curr Opin Cell Biol 21:825-36. 2009
  2. ncbi DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates
    O Folmer
    Center for Theoretical and Applied Genetics, Rutgers University, New Brunswick, New Jersey 08903 231
    Mol Mar Biol Biotechnol 3:294-9. 1994
  3. ncbi The prophenoloxidase-activating system in invertebrates
    Lage Cerenius
    Department of Comparative Physiology, Evolutionary Biology Center, Uppsala University, Uppsala, Sweden
    Immunol Rev 198:116-26. 2004
  4. ncbi Depletion, degradation, and recovery potential of estuaries and coastal seas
    Heike K Lotze
    Biology Department, Dalhousie University, 1355 Oxford Street, Halifax, NS, Canada B3H 4J1
    Science 312:1806-9. 2006
  5. ncbi Evolution and biogeography of deep-sea vent and seep invertebrates
    C L Van Dover
    Biology Department, College of William and Mary, Williamsburg, VA 23187, USA
    Science 295:1253-7. 2002
  6. ncbi The role of discharge variation in scaling of drainage area and food chain length in rivers
    John L Sabo
    Faculty of Ecology, Evolution, and Environmental Sciences, School of Life Sciences, Arizona State University, Post Office Box 874501, Tempe, AZ 85287 4501, USA
    Science 330:965-7. 2010
  7. pmc The primary role of fibrinogen-related proteins in invertebrates is defense, not coagulation
    Patrick C Hanington
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    J Innate Immun 3:17-27. 2011
  8. ncbi Coagulation systems of invertebrates and vertebrates and their roles in innate immunity: the same side of two coins?
    Torsten G Loof
    Department of Clinical Sciences, Lund University, Lund, Sweden
    J Innate Immun 3:34-40. 2011
  9. pmc MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals
    Anna Wredenberg
    Max Planck Institute for Biology of Ageing, Koln, Germany
    PLoS Genet 9:e1003178. 2013
  10. ncbi Evidence for multiple reversals of asymmetric mutational constraints during the evolution of the mitochondrial genome of metazoa, and consequences for phylogenetic inferences
    Alexandre Hassanin
    Museum national d histoire naturelle, Départment Systématique et Evolution, Case Postale, Paris, France
    Syst Biol 54:277-98. 2005

Detail Information

Publications344 found, 100 shown here

  1. ncbi TOR signaling in invertebrates
    Alexandre Soulard
    Biozentrum, University of Basel, Basel, Switzerland
    Curr Opin Cell Biol 21:825-36. 2009
    ..TOR is found in two functionally distinct complexes, TORC1 and TORC2. In this review we address the most recent advances in TOR signaling in invertebrate model organisms, including yeasts, plants, worms, and insects...
  2. ncbi DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates
    O Folmer
    Center for Theoretical and Applied Genetics, Rutgers University, New Brunswick, New Jersey 08903 231
    Mol Mar Biol Biotechnol 3:294-9. 1994
    ..Preliminary comparisons revealed that these COI primers generate informative sequences for phylogenetic analyses at the species and higher taxonomic levels...
  3. ncbi The prophenoloxidase-activating system in invertebrates
    Lage Cerenius
    Department of Comparative Physiology, Evolutionary Biology Center, Uppsala University, Uppsala, Sweden
    Immunol Rev 198:116-26. 2004
    A major innate defense system in invertebrates is the melanization of pathogens and damaged tissues...
  4. ncbi Depletion, degradation, and recovery potential of estuaries and coastal seas
    Heike K Lotze
    Biology Department, Dalhousie University, 1355 Oxford Street, Halifax, NS, Canada B3H 4J1
    Science 312:1806-9. 2006
    ..Our results provide detailed historical baselines and quantitative targets for ecosystem-based management and marine conservation...
  5. ncbi Evolution and biogeography of deep-sea vent and seep invertebrates
    C L Van Dover
    Biology Department, College of William and Mary, Williamsburg, VA 23187, USA
    Science 295:1253-7. 2002
    ..Most vent and seep invertebrates arrive at suitable habitats as larvae dispersed by deep-ocean currents...
  6. ncbi The role of discharge variation in scaling of drainage area and food chain length in rivers
    John L Sabo
    Faculty of Ecology, Evolution, and Environmental Sciences, School of Life Sciences, Arizona State University, Post Office Box 874501, Tempe, AZ 85287 4501, USA
    Science 330:965-7. 2010
    ..Ecosystem size lengthens river food chains by integrating and attenuating discharge variation through stream networks, thereby enhancing environmental stability in larger river systems...
  7. pmc The primary role of fibrinogen-related proteins in invertebrates is defense, not coagulation
    Patrick C Hanington
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    J Innate Immun 3:17-27. 2011
    ..In invertebrates, fibrinogen-domain-containing proteins play a role in the defense response generated against pathogens; ..
  8. ncbi Coagulation systems of invertebrates and vertebrates and their roles in innate immunity: the same side of two coins?
    Torsten G Loof
    Department of Clinical Sciences, Lund University, Lund, Sweden
    J Innate Immun 3:34-40. 2011
    ..Many invertebrates have an open circulatory system, and effective coagulation systems are in place to ensure fast and efficient ..
  9. pmc MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals
    Anna Wredenberg
    Max Planck Institute for Biology of Ageing, Koln, Germany
    PLoS Genet 9:e1003178. 2013
  10. ncbi Evidence for multiple reversals of asymmetric mutational constraints during the evolution of the mitochondrial genome of metazoa, and consequences for phylogenetic inferences
    Alexandre Hassanin
    Museum national d histoire naturelle, Départment Systématique et Evolution, Case Postale, Paris, France
    Syst Biol 54:277-98. 2005
  11. ncbi A comparative review of short and long neuropeptide F signaling in invertebrates: Any similarities to vertebrate neuropeptide Y signaling?
    Dick R Nassel
    Department of Zoology, Stockholm University, S 10691 Stockholm, Sweden
    Peptides 32:1335-55. 2011
    ..We discuss the distribution and functions of NPFs and their receptors in several model invertebrates. Signaling with sNPF, however, has been investigated mainly in insects, especially in Drosophila...
  12. ncbi Quantifying the "bio-" components in biophysical models of larval transport in marine benthic invertebrates: advances and pitfalls
    Anna Metaxas
    Department of Oceanography, Dalhousie University, Halifax, Nova Scotia B3H 4J1, Canada
    Biol Bull 216:257-72. 2009
    ..and behavior in the water column have exhibited pronounced effects on larval dispersal of marine benthic invertebrates. The parameterization of these processes has broadly reflected values from laboratory experiments, but the ..
  13. pmc Trends in the discovery of new marine natural products from invertebrates over the last two decades--where and what are we bioprospecting?
    Miguel Costa Leal
    Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal
    PLoS ONE 7:e30580. 2012
    It is acknowledged that marine invertebrates produce bioactive natural products that may be useful for developing new drugs...
  14. ncbi The origins of the arthropod nervous system: insights from the Onychophora
    Paul M Whitington
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria 3010, Australia
    Arthropod Struct Dev 40:193-209. 2011
    ..evolutionary scenario, by which the arthropod nervous system evolved from a system of orthogonally crossing nerve tracts present in both a presumed protostome ancestor and many extant worm-like invertebrates, including the onychophorans.
  15. pmc Ecdysozoan mitogenomics: evidence for a common origin of the legged invertebrates, the Panarthropoda
    Omar Rota-Stabelli
    Department of Genetics, Evolution and Environment, University College London, London, United Kingdom
    Genome Biol Evol 2:425-40. 2010
    ..The same analyses also recover monophyly of traditionally recognized arthropod lineages such as Arachnida and of the highly debated clade Mandibulata...
  16. ncbi Animal behaviour: emotion in invertebrates?
    Michael Mendl
    Centre for Behavioural Biology, School of Veterinary Science, University of Bristol, Langford, BS40 5DU, UK
    Curr Biol 21:R463-5. 2011
  17. ncbi Energy homeostasis as an integrative tool for assessing limits of environmental stress tolerance in aquatic invertebrates
    Inna M Sokolova
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC, USA
    Mar Environ Res 79:1-15. 2012
    ..We explore the links between metabolism, energy balance and stress tolerance using aquatic invertebrates as an example and demonstrate that using key parameters of energy balance (aerobic scope for growth, ..
  18. ncbi Motor primitives in vertebrates and invertebrates
    Tamar Flash
    Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel
    Curr Opin Neurobiol 15:660-6. 2005
    ..different lines of evidence have led to the idea that motor actions and movements in both vertebrates and invertebrates are composed of elementary building blocks...
  19. ncbi The Trichoplax genome and the nature of placozoans
    Mansi Srivastava
    Center for Integrative Genomics and Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nature 454:955-60. 2008
  20. ncbi Extinction and ecosystem function in the marine benthos
    Martin Solan
    Oceanlab, University of Aberdeen, Main Street, Newburgh, Aberdeenshire, Scotland AB41 6AA
    Science 306:1177-80. 2004
    ..As a result, the particular cause of extinction and the order in which species are lost ultimately govern the ecosystem-level consequences of biodiversity loss...
  21. ncbi Identification of the novel evolutionary conserved obstructor multigene family in invertebrates
    Matthias Behr
    Institut für Molekulare Physiologie und Entwicklungsbiologie der Universität Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Abt für Molekulare Entwicklungsbiologie, Poppelsdorfer Schloss, 53115 Bonn, Germany
    FEBS Lett 579:6827-33. 2005
    ..Using computational and phylogenetic analysis, we show that obstructor genes represent an evolutionary conserved multigene family in invertebrates.
  22. ncbi Signalling through pigment dispersing hormone-like peptides in invertebrates
    E Meelkop
    Laboratory of Functional Genomics and Proteomics, Zoological Institute, K U Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    Prog Neurobiol 93:125-47. 2011
    ..In addition, a brief comparison with the vertebrate system is made...
  23. pmc Conventional and unconventional antimicrobials from fish, marine invertebrates and micro-algae
    Valerie J Smith
    Scottish Oceans Institute, University of St Andrews, St Andrews, KY16 8LB, Scotland, UK
    Mar Drugs 8:1213-62. 2010
    ..This review discusses the nature, biological role in host protection and potential biotechnological uses of some of these compounds, focusing on those from fish, marine invertebrates and marine micro-algae.
  24. ncbi A new synthesis in epigenetics: towards a unified function of DNA methylation from invertebrates to vertebrates
    M Mandrioli
    Dipartimento di Biologia Animale, Universita di Modena e Reggio Emilia, Via Campi 213 D, 41100, Modena, Italy
    Cell Mol Life Sci 64:2522-4. 2007
    ..Actually, gene body methylation is not surprising since it has been repeatedly reported in invertebrates, where it interferes with transcriptional elongation preventing aberrant transcription initiations...
  25. ncbi Does life history predict past and current connectivity for rocky intertidal invertebrates across a marine biogeographic barrier?
    D J Ayre
    Institute for Conservation Biology and School of Biological Sciences, University of Wollongong, NSW, Australia
    Mol Ecol 18:1887-1903. 2009
    ..Indeed, the species that displayed little or no evidence of a phylogeographic break across the barrier each displayed unexpectedly relaxed habitat specificity...
  26. ncbi Methods for isolation, purification and structural elucidation of bioactive secondary metabolites from marine invertebrates
    Sherif S Ebada
    Institut fur Pharmazeutische Biologie und Biotechnologie, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Nat Protoc 3:1820-31. 2008
    ..methods for bioactivity-guided isolation, purification and identification of secondary metabolites from marine invertebrates such as sponges, tunicates, soft corals and crinoids are discussed...
  27. ncbi Analyzing effects of pesticides on invertebrate communities in streams
    Matthias Liess
    UFZ Centre for Environmental Research, Permoserstrasse 15, D 04318 Leipzig, Germany
    Environ Toxicol Chem 24:954-65. 2005
    ..The results emphasize the importance of considering ecological traits and recolonization processes on the landscape level for ecotoxicological risk assessment...
  28. ncbi The Burgess Shale anomalocaridid Hurdia and its significance for early euarthropod evolution
    Allison C Daley
    Department of Earth Sciences, Palaeobiology, Uppsala University, Villavägen 16, Uppsala SE 752 36, Sweden
    Science 323:1597-600. 2009
    ..These features amplify and clarify the diversity of known anomalocaridid morphology and provide insight into the origins of important arthropod features, such as the head shield and respiratory exites...
  29. pmc Biosynthetic origin of natural products isolated from marine microorganism-invertebrate assemblages
    T Luke Simmons
    Scripps Institution of Oceanography, Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093
    Proc Natl Acad Sci U S A 105:4587-94. 2008
    ..Examples are given from the literature as well as recent proof-of-concept experiments from the authors' laboratories...
  30. ncbi When gaps really are gaps: statistical phylogeography of hydrothermal vent invertebrates
    Asta Audzijonyte
    Monterey Bay Aquarium Research Institute, 7700 Sandholdt Road, Moss Landing, California 95039, USA
    Evolution 64:2369-84. 2010
    ..The simulation approaches presented here might be useful for testing the significance of inferred phylogeographic gaps in other species...
  31. ncbi Metabolic interactions between algal symbionts and invertebrate hosts
    David Yellowlees
    ARC Centre of Excellence for Coral Reef Studies and School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Queensland 4811, Australia
    Plant Cell Environ 31:679-94. 2008
    Some invertebrates have enlisted autotrophic unicellular algae to provide a competitive metabolic advantage in nutritionally demanding habitats...
  32. ncbi Colonization of organic substrates deployed in deep-sea reducing habitats by symbiotic species and associated fauna
    S M Gaudron
    Universite Pierre et Marie Curie, Paris VI, CNRS, UMR7138, Systématique, Adaptation, Evolution, Equipe AMEX, Batiment A 4 Eme Etage Pièce 415, 7 quai St Bernard, 75252 Paris Cedex 05, France
    Mar Environ Res 70:1-12. 2010
    ..series of novel standardized colonization devices (CHEMECOLI: CHEMosynthetic Ecosystem COlonization by Larval Invertebrates) filled with three types of substrates (wood, alfalfa and carbonate) have been deployed in different types of ..
  33. ncbi Halwaxiids and the early evolution of the lophotrochozoans
    Simon Conway Morris
    Department of Earth Sciences, University of Cambridge, Cambridge CB2 3EQ, UK
    Science 315:1255-8. 2007
    ..This new fossil defines the monophyletic halwaxiids and indicates that they have a key place in early lophotrochozoan history...
  34. ncbi Environmental impact of diuron transformation: a review
    S Giacomazzi
    Equipe de Physiologie Microbienne, UMR 6067, CNRS, Génie des Procédés Industriels, Universite de Technologie de Compiegne, BP 20529, Compiègne Cedex 60205, France
    Chemosphere 56:1021-32. 2004
    ..It is also slightly toxic to mammals and birds as well as moderately toxic to aquatic invertebrates. However, its principal product of biodegradation, 3,4-dichloroaniline exhibits a higher toxicity and is also ..
  35. ncbi Neural stem cell biology in vertebrates and invertebrates: more alike than different?
    Andrea H Brand
    The Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, UK
    Neuron 70:719-29. 2011
    ..similarities in the cell and molecular biology of neural stem cell self-renewal and differentiation between invertebrates and vertebrates...
  36. pmc Evolution of the globin gene family in deuterostomes: lineage-specific patterns of diversification and attrition
    Federico G Hoffmann
    Department of Biochemistry and Molecular Biology, Mississippi State University, USA
    Mol Biol Evol 29:1735-45. 2012
  37. pmc Development of the nervous system in Phoronopsis harmeri (Lophotrochozoa, Phoronida) reveals both deuterostome- and trochozoan-like features
    Elena Temereva
    Department of Invertebrate Zoology, Biological Faculty, Moscow State University, Moscow 119991, Russia
    BMC Evol Biol 12:121. 2012
  38. ncbi Molecular paleobiological insights into the origin of the Brachiopoda
    Erik A Sperling
    Department of Geology and Geophysics, Yale University, New Haven, CT 06520, USA
    Evol Dev 13:290-303. 2011
  39. pmc A new family of receptor tyrosine kinases with a venus flytrap binding domain in insects and other invertebrates activated by aminoacids
    Arnaud Ahier
    INSERM U547, Universite de Lille 2, Institut Pasteur de Lille, Lille, France
    PLoS ONE 4:e5651. 2009
  40. ncbi The evolutionary ecology of offspring size in marine invertebrates
    Dustin J Marshall
    School of Integrative Biology Centre for Marine Studies, University of Queensland, Queensland, Australia
    Adv Mar Biol 53:1-60. 2007
    ..Here we review the incidence and consequences of intraspecific offspring-size variation for marine invertebrates. Offspring size is remarkably variable within and among marine invertebrate populations...
  41. ncbi Global change ecotoxicology: Identification of early life history bottlenecks in marine invertebrates, variable species responses and variable experimental approaches
    M Byrne
    Schools of Medical and Biological Science, University of Sydney, NSW 2006, Australia
    Mar Environ Res 76:3-15. 2012
    ..Exposure to climate change stressors from early development (fertilization where possible) in multistressor experiments is needed to identify ontogenetic sensitivities and this will be facilitated by more consistent methodologies...
  42. pmc Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates
    Lisa Nanty
    The Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, United Kingdom
    Genome Res 21:1841-50. 2011
    In invertebrates that harbor functional DNA methylation enzymatic machinery, gene-bodies are the primary targets for CpG methylation. However, virtually all other aspects of invertebrate DNA methylation have remained a mystery until now...
  43. ncbi Use of habitats as surrogates of biodiversity for efficient coral reef conservation planning in Pacific Ocean islands
    Mayeul Dalleau
    Institut de Recherche pour le Developpement, Centre de Nouméa, B P A5, 98848 Noumea, New Caledonia
    Conserv Biol 24:541-52. 2010
    ..Habitat surrogacy was tested for commercial fish species, all fish species, commercially harvested invertebrates, corals, and algae species...
  44. ncbi The phylogenetic distribution of metazoan microRNAs: insights into evolutionary complexity and constraint
    Lorenzo F Sempere
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    J Exp Zool B Mol Dev Evol 306:575-88. 2006
  45. pmc Modelling rate distributions using character compatibility: implications for morphological evolution among fossil invertebrates
    Peter J Wagner
    National Museum of Natural History, Smithsonian Institution, Washington, DC 20013, USA
    Biol Lett 8:143-6. 2012
    ..Moreover, the lognormal outperforms the gamma for character change rates and (especially) state derivation rates. The latter in particular is consistent with integration affecting morphological character evolution...
  46. ncbi Invertebrate intracellular fatty acid binding proteins
    Adriana Esteves
    Seccion Bioquimica, Dpto de Biología Celular y Molecular, Facultad de Ciencias Montevideo, Uruguay
    Comp Biochem Physiol C Toxicol Pharmacol 142:262-74. 2006
    ..isolation of the first invertebrate FABP from Schistocerca gregaria in 1990, the number of FABPs isolated from invertebrates has been increasing...
  47. pmc The stochastic nature of larval connectivity among nearshore marine populations
    D A Siegel
    Institute for Computational Earth System Science, Department of Geography, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 105:8974-9. 2008
    ..Many of the fishes and invertebrates that comprise nearshore fisheries are relatively sedentary as adults but have an obligate larval pelagic stage ..
  48. ncbi Uptake and depuration of pharmaceuticals in aquatic invertebrates
    Melanie Meredith-Williams
    Environment Department, University of York, Heslington, York YO10 5DD, UK
    Environ Pollut 165:250-8. 2012
    ..BCFs of the pharmaceuticals for each organism were correlated to the pH-corrected liposome-water partition coefficient of the pharmaceuticals...
  49. ncbi Fecundity and life-history strategies in marine invertebrates
    Eva Ramirez Llodra
    School of Ocean and Earth Science, Southampton University, Southampton Oceanography Centre, European Way, Southampton SO14 3ZH, UK
    Adv Mar Biol 43:87-170. 2002
    ..eggs) and spermatogenesis (the production of sperm), the basic patterns of gametogenesis are similar amongst invertebrates, with the proliferation and differentiation of germ cells leading to the final production of mature gametes...
  50. ncbi Metapopulation structure of Vibrionaceae among coastal marine invertebrates
    Sarah P Preheim
    Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Environ Microbiol 13:265-75. 2011
    ..Instead, many of the populations show stronger association with planktonic (micro)habitats while the microbiome may be a fairly open system for vibrios in which high rates of immigration can outpace selection for specialization...
  51. pmc Marine biodiversity-ecosystem functions under uncertain environmental futures
    Mark T Bulling
    Oceanlab, University of Aberdeen, Main Street, Newburgh, Aberdeenshire AB41 6AA, UK
    Philos Trans R Soc Lond B Biol Sci 365:2107-16. 2010
  52. ncbi Invading rainbow trout usurp a terrestrial prey subsidy from native charr and reduce their growth and abundance
    Colden V Baxter
    Graduate Degree Program in Ecology, and Department of Fish, Wildlife, and Conservation Biology, Colorado State University, Fort Collins, CO 80523, USA
    Oecologia 153:461-70. 2007
    ..A large-scale field experiment showed that excluding terrestrial invertebrates that fell into the stream with a mesh greenhouse reduced terrestrial prey in diets of native Dolly Varden ..
  53. ncbi Ultrastructure of mesoderm in embryos of Opisthopatus roseus (Onychophora, Peripatopsidae): revision of the "long germ band" hypothesis for Opisthopatus
    Georg Mayer
    Animal Systematics and Evolution, Institute of Biology Zoology, Freie Universität of Berlin, D 14195 Berlin, Germany
    J Morphol 263:60-70. 2005
    ..cinctipes. From this survey, no evidence in support of a "long germ band" hypothesis in Opisthopatus was found. Instead, the embryogenesis in representatives of Opisthopatus is more similar to that in other onychophorans than expected...
  54. ncbi Freeze tolerance, supercooling points and ice formation: comparative studies on the subzero temperature survival of limno-terrestrial tardigrades
    S Hengherr
    Universitat Stuttgart, Biological Institute, Department of Zoology, Pfaffenwaldring 57, 70569 Stuttgart, Germany
    J Exp Biol 212:802-7. 2009
    ..These results expand our current understanding of freeze tolerance in tardigrades and will lead to a better understanding of their ability to survive subzero temperature conditions...
  55. ncbi Head patterning and Hox gene expression in an onychophoran and its implications for the arthropod head problem
    Bo Joakim Eriksson
    University Museum of Zoology and Department of Zoology, Downing Street, Cambridge, CB2 3EJ, UK
    Dev Genes Evol 220:117-22. 2010
    ..Our data provide molecular support for the proposal that the onychophoran head possesses a well-developed appendage that corresponds to the anterior, apparently appendage-less region of the arthropod head...
  56. ncbi Neuromuscular development in Novocrania anomala: evidence for the presence of serotonin and a spiralian-like apical organ in lecithotrophic brachiopod larvae
    Andreas Altenburger
    Department of Biology, Research Group for Comparative Zoology, University of Copenhagen, Universitetsparken 15, Copenhagen Ø, Denmark
    Evol Dev 12:16-24. 2010
  57. ncbi It's about time: divergence, demography, and the evolution of developmental modes in marine invertebrates
    Michael W Hart
    Department of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada
    Integr Comp Biol 50:643-61. 2010
  58. ncbi Phanerozoic trends in the global diversity of marine invertebrates
    John Alroy
    National Center for Ecological Analysis and Synthesis, University of California Santa Barbara, 735 State Street, Santa Barbara, CA 93101, USA
    Science 321:97-100. 2008
    It has previously been thought that there was a steep Cretaceous and Cenozoic radiation of marine invertebrates. This pattern can be replicated with a new data set of fossil occurrences representing 3...
  59. ncbi Network analysis reveals contrasting effects of intraspecific competition on individual vs. population diets
    Márcio S Araújo
    Departamento de Parasitologia, Programa de Pos Graduacao em Ecologia, Instituto de Biologia, Universidade Estadual de Campinas, CP 6109, 13083 970, Campinas, SP, Brazil
    Ecology 89:1981-93. 2008
  60. ncbi Metabolites from symbiotic bacteria
    Jorn Piel
    Max Planck Institute for Chemical Ecology, Department of Bioorganic Chemistry, Hans Knoll Strasse 8, Beutenberg Campus, 07745 Jena, Germany
    Nat Prod Rep 21:519-38. 2004
    ..This review describes natural products that are shown or suspected to be synthesized by symbiotic bacteria. It includes 349 references and covers the literature in this field through 2003...
  61. ncbi Fungicide risk assessment for aquatic ecosystems: importance of interspecific variation, toxic mode of action, and exposure regime
    Lorraine Maltby
    Department of Animal and Plant Sciences, The University of Sheffield, Sheffield S10 2TN, UK
    Environ Sci Technol 43:7556-63. 2009
    The risk assessment of fungicides in Europe uses information from ecotoxicity studies performed on vertebrates, invertebrates, and primary producers, but not nontarget fungi...
  62. ncbi The continuing conundrum of the LEA proteins
    Alan Tunnacliffe
    Institute of Biotechnology, University of Cambridge, Cambridge, UK
    Naturwissenschaften 94:791-812. 2007
    ..Homologues of groups 1 and 3 proteins have also been found in bacteria and in certain invertebrates. In this review, we present some new data, survey the biochemistry, biophysics and bioinformatics of the LEA ..
  63. pmc Deep genomic-scale analyses of the metazoa reject Coelomata: evidence from single- and multigene families analyzed under a supertree and supermatrix paradigm
    Thérèse A Holton
    Department of Biology, National University of Ireland, Maynooth, Maynooth Co Kildare, Ireland
    Genome Biol Evol 2:310-24. 2010
    ..We show that optimal outgroup selection is key in avoiding LBA and identify the use of inadequate outgroups as the reason previous deep genomic-scale analyses found strong support for Coelomata...
  64. ncbi A generation time effect on the rate of molecular evolution in invertebrates
    Jessica A Thomas
    Department of Ecology, Evolution and Natural Resources, Rutgers University, Cook Campus, USA
    Mol Biol Evol 27:1173-80. 2010
    ..Here, we present the first general test of the GT effect in invertebrates, using 15 genes from 143 species spread across the major eumetazoan superphyla (including arthropods, ..
  65. ncbi Antimicrobial peptides from marine invertebrates as a new frontier for microbial infection control
    Anselmo Jesus Otero-González
    Centro de Estudios de Proteínas, Universidad de La Habana, Havana, Cuba
    FASEB J 24:1320-34. 2010
    ..In invertebrates, antimicrobial peptides represent the major humoral defense system against infection, showing a diverse ..
  66. ncbi Metallothioneins in aquatic invertebrates: their role in metal detoxification and their use as biomarkers
    J C Amiard
    Universite de Nantes, Pôle Mer et Littoval, SMAB EA 2160, Service d Ecotoxicologie, Nantes, France
    Aquat Toxicol 76:160-202. 2006
    The literature on metallothioneins (MT) and metallothionein-like proteins (MTLP) in aquatic invertebrates is large and increasing, and yet inconsistencies and confusion remain, not least over the physiological role of MT and their use as ..
  67. ncbi A truce with neutral theory: local deterministic factors, species traits and dispersal limitation together determine patterns of diversity in stream invertebrates
    Ross Thompson
    Biodiversity Research Centre, University of British Columbia, 6270 University Blvd, Vancouver, BC, Canada V6T 1Z4
    J Anim Ecol 75:476-84. 2006
    ..6. We emphasize the potential for both dispersal processes and local environmental conditions to explain local patterns of diversity...
  68. pmc Units of plasticity in bacterial genomes: new insight from the comparative genomics of two bacteria interacting with invertebrates, Photorhabdus and Xenorhabdus
    Jean Claude Ogier
    INRA, UMR 1133, Laboratoire EMIP, Place Eugene Bataillon, F 34095 Montpellier, France
    BMC Genomics 11:568. 2010
    ..we investigated plasticity units in bacterial genomes, by exhaustive description of the RGPs in two Photorhabdus and two Xenorhabdus strains, belonging to the Enterobacteriaceae and interacting with invertebrates (insects and nematodes).
  69. ncbi A multi criterion approach for the selection of optimal outgroups in phylogeny: recovering some support for Mandibulata over Myriochelata using mitogenomics
    Omar Rota-Stabelli
    Research Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Mol Phylogenet Evol 48:103-11. 2008
    ..Finally, we advocate a careful analysis and an objective choice of outgroup when dealing with derived sequences, such as mitochondrial genomes...
  70. ncbi Evaluating connectivity in the brooding brittle star Astrotoma agassizii across the drake passage in the Southern Ocean
    Rebecca L Hunter
    Department of Biological Sciences, Auburn University, 101 Rouse Life Sciences Building, Auburn, AL 36849, USA
    J Hered 99:137-48. 2008
    Studies examining population structure and genetic diversity of benthic marine invertebrates in the Southern Ocean have emerged in recent years...
  71. pmc The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates
    Noa Sela
    Department of Human Molecular Genetics, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Genome Biol 11:R59. 2010
    ..However, no extensive analysis has compared the effects of TEs on the transcriptomes of mammals, non-mammalian vertebrates and invertebrates.
  72. ncbi Relative sensitivity distribution of aquatic invertebrates to organic and metal compounds
    Peter Carsten Von Der Ohe
    Department of Chemical Ecotoxicology, UFZ Centre for Environmental Research, Permoserstrasse 15, 04318 Leipzig, Germany
    Environ Toxicol Chem 23:150-6. 2004
    ..The sensitivities for several taxa are listed, and use of the relative sensitivity distribution to link toxicant effects in mesocosm studies and field investigations is discussed...
  73. ncbi Apical organs in echinoderm larvae: insights into larval evolution in the Ambulacraria
    Maria Byrne
    Department of Anatomy and Histology, F13, University of Sydney, NSW 2006, Australia
    Evol Dev 9:432-45. 2007
    ..From this structure, the apical organ has been independently modified in association with the evolution of class-specific larval forms...
  74. ncbi The influence of intraguild predation on prey suppression and prey release: a meta-analysis
    Heather D Vance-Chalcraft
    Department of Biology, East Carolina University, Greenville, North Carolina 27858, USA
    Ecology 88:2689-96. 2007
    ..terrestrial invertebrate, and terrestrial vertebrate), with the strongest patterns being driven by terrestrial invertebrates. Finally, although IGP theory is based on equilibrium conditions, data from short-term experiments can inform ..
  75. pmc Common trends in mutualism revealed by model associations between invertebrates and bacteria
    John Chaston
    Department of Bacteriology, University of Wisconsin Madison, Madison, WI 53706, USA
    FEMS Microbiol Rev 34:41-58. 2010
  76. ncbi Large-scale parsimony analysis of metazoan indels in protein-coding genes
    Frida Belinky
    Department of Zoology, Tel Aviv University, Israel
    Mol Biol Evol 27:441-51. 2010
    ..Our indel-based inferences support the Ecdysozoa hypothesis over the Coelomata hypothesis and suggest that sponges are a sister clade to other animals...
  77. ncbi Strategies to establish left/right asymmetry in vertebrates and invertebrates
    Pauline Speder
    ISBDC, University of Nice Sophia Antipolis, CNRS, Parc Valrose, 06108 Nice Cedex 2, France
    Curr Opin Genet Dev 17:351-8. 2007
    ..In protostomes like snails and Drosophila, symmetry breaking relies on different mechanisms, involving, in particular, the actin cytoskeleton and associated molecular motors...
  78. ncbi Upwelling-driven nearshore hypoxia signals ecosystem and oceanographic changes in the northeast Pacific
    Brian A Grantham
    Washington State Department of Ecology, Coastal and Estuarine Assessment Unit, Olympia, Washington 98504, USA
    Nature 429:749-54. 2004
    ..the unprecedented development of severe inner-shelf (<70 m) hypoxia and resultant mass die-offs of fish and invertebrates within the California Current System...
  79. ncbi Cytotoxicity of diatom-derived oxylipins in organisms belonging to different phyla
    Sven Adolph
    Max Planck Institute, Hans Knöll Str 8, D 07745 Jena, Germany
    J Exp Biol 207:2935-46. 2004
    ..Experiments with a genetically modified yeast species exhibiting elevated membrane and/or cell wall permeability suggest that this protection can be related to the inability of the oxylipin compounds to enter the cell...
  80. ncbi Anti-microbial peptides: from invertebrates to vertebrates
    Philippe Bulet
    Atheris Laboratories, Geneva, Switzerland
    Immunol Rev 198:169-84. 2004
    ..This review focuses on AMPs forming alpha-helices, beta-hairpin-like beta-sheets, beta-sheets, or alpha-helix/beta-sheet mixed structures from invertebrate and vertebrate origins. These molecules show some promise for therapeutic use...
  81. ncbi Population size does not influence mitochondrial genetic diversity in animals
    Eric Bazin
    CNRS UMR 5171 Génome, Populations, Interactions, Adaptation Université Montpellier 2 34095 Montpellier Cedex 5, France
    Science 312:570-2. 2006
    ..DNA (mtDNA) marker does not reflect species abundance or ecology: mtDNA diversity is not higher in invertebrates than in vertebrates, in marine than in terrestrial species, or in small than in large organisms...
  82. ncbi Mycobacterium ulcerans in wild animals
    F Portaels
    Mycobacteriology Unit, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerpen, Belgium
    Rev Sci Tech 20:252-64. 2001
    ..To address this question, surveys of wild animals are urgently required in those areas in which Buruli ulcer is endemic...
  83. ncbi Non-methylene-interrupted fatty acids from marine invertebrates: Occurrence, characterization and biological properties
    Gilles Barnathan
    Universite de Nantes, France
    Biochimie 91:671-8. 2009
    Marine organisms, in particular invertebrates, have proved to be a major source of unique fatty acid (FA) structures originating from unusual biosynthetic pathways...
  84. ncbi Effects of hardness, chloride, and acclimation on the acute toxicity of sulfate to freshwater invertebrates
    David John Soucek
    Center for Ecological Entomology, Illinois Natural History Survey, Champaign, Illinois 61820, USA
    Environ Toxicol Chem 24:1204-10. 2005
    ..dubia increased to 2,526 mg/L. Acclimation of C. dubia to 500 and 1,000 mg SO4(-2)/L for several generations nominally increased mean LC50 values compared with those cultured in standard MHRW...
  85. ncbi Developments in aquatic insect biomonitoring: a comparative analysis of recent approaches
    Núria Bonada
    CNRS UMR5023, Ecologie des Hydrosystèmes Fluviaux, Universite Lyon 1, Villeurbanne, France
    Annu Rev Entomol 51:495-523. 2006
    Aquatic insects and other benthic invertebrates are the most widely used organisms in freshwater biomonitoring of human impact...
  86. ncbi Phylogenetic relationships within the lophophorate lineages (Ectoprocta, Brachiopoda and Phoronida)
    Bernhard Hausdorf
    Zoological Museum of the University of Hamburg, Martin Luther King Platz 3, 20146 Hamburg, Germany
    Mol Phylogenet Evol 55:1121-7. 2010
    ..The hypotheses that phoronids are the sister group of articulate or inarticulate brachiopods could be rejected by topology tests, thus confirming the monophyly of Brachiopoda...
  87. ncbi Structure-function relationship of anticoagulant and antithrombotic well-defined sulfated polysaccharides from marine invertebrates
    Vitor H Pomin
    Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
    Adv Food Nutr Res 65:195-209. 2012
  88. pmc Meroterpenes from marine invertebrates: structures, occurrence, and ecological implications
    Marialuisa Menna
    The NeaNAT group, Dipartimento di Farmacia, Universita degli Studi di Napoli Federico II, via D Montesano 49, 80131 Napoli, Italy
    Mar Drugs 11:1602-43. 2013
    ..they are particularly abundant within brown algae, but other important sources include microorganisms and invertebrates. In the present review the structures and bioactivities of meroterpenes from marine invertebrates, mainly ..
  89. ncbi Physiology is pivotal for interactions between salinity and acute copper toxicity to fish and invertebrates
    M Grosell
    Marine Biology and Fisheries, RSMAS, University of Miami, Miami, FL 33149 1098, USA
    Aquat Toxicol 84:162-72. 2007
    ..The existing literature on the influence of salinity on acute Cu toxicity as well as studies of mechanisms of Cu toxicity in fish and invertebrates are reviewed.
  90. ncbi Aggression in invertebrates
    Edward A Kravitz
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Neurobiol 13:736-43. 2003
    b>Invertebrates are outstanding model systems for the study of aggression...
  91. pmc The retinal mosaics of opsin expression in invertebrates and vertebrates
    Jens Rister
    Department of Biology, Center for Developmental Genetics, New York University, USA
    Dev Neurobiol 71:1212-26. 2011
  92. ncbi Role of Bcl-2 family members in invertebrates
    Tatsushi Igaki
    Department of Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 0033, Japan
    Biochim Biophys Acta 1644:73-81. 2004
    ..The ancestral role of the Bcl-2 family protein may be pro-apoptotic, and the evolution of the functions of this family of proteins may be closely linked with the contribution of mitochondria to the cell death pathway...
  93. ncbi Quantifying population recovery rates for ecological risk assessment
    Lawrence W Barnthouse
    LWB Environmental Services, 105 Wesley Lane, Oak Ridge, Tennessee 37830, USA
    Environ Toxicol Chem 23:500-8. 2004
  94. ncbi Climate and recruitment of rocky shore intertidal invertebrates in the eastern North Atlantic
    Bernardo R Broitman
    National Center for Ecological Analysis and Synthesis, State Street 735, Suite 300, Santa Barbara, California 93101, USA
    Ecology 89:S81-90. 2008
    ..Here we evaluate the effects of the NAO on recruitment variability of rocky intertidal invertebrates in the North Atlantic examining two possible climate-related pathways...
  95. ncbi Habitat-specific bioaccumulation of methylmercury in invertebrates of small mid-latitude lakes in North America
    John Chételat
    Groupe de recherche interuniversitaire en limnologie, Departement de sciences biologiques, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    Environ Pollut 159:10-7. 2011
    ..Intensive sampling of 8 lakes indicated that habitat-specific bioaccumulation in invertebrates (of similar trophic level) may result from spatial variation in aqueous MeHg concentration or from more ..
  96. ncbi Antimicrobial peptides from marine invertebrates: challenges and perspectives in marine antimicrobial peptide discovery
    Sigmund V Sperstad
    Norwegian College of Fishery Science, Faculty of Biosciences, Fisheries and Economics, University of Tromsø, N 9037 Tromsø, Norway
    Biotechnol Adv 29:519-30. 2011
    ..In the present review we discuss antimicrobial peptides isolated from marine invertebrates, emphasizing the isolation and activity of these natural antibiotics...
  97. ncbi Predator diversity strengthens trophic cascades in kelp forests by modifying herbivore behaviour
    Jarrett Byrnes
    Ecol Lett 9:61-71. 2006
    ..Our results suggest that declining predator diversity can have cascading effects on community structure by reducing the abundance of key habitat-providing species...
  98. ncbi Operant conditioning in invertebrates
    Björn Brembs
    Department of Neurobiology and Anatomy, The University of Texas Houston Medical School, 6431 Fannin, MSB 7 312, Houston, Texas 77030, USA
    Curr Opin Neurobiol 13:710-7. 2003
    ..operant conditioning) is a simple form of learning that humans share with most other animals, including invertebrates. Three model organisms have recently made significant contributions towards a mechanistic model of operant ..
  99. ncbi Metal effects on soil invertebrate feeding: measurements using the bait lamina method
    Petra D B Filzek
    Institute of Landscape Ecology, University of Muenster, Robert Koch Str 26 28, 48149 Muenster, Germany
    Ecotoxicology 13:807-16. 2004
    ..of soil functional integrity (the bait lamina test) that is designed to measure the feeding activity of soil invertebrates. Bait lamina was used at six grassland sites located along a transect from a smelter at Avonmouth (South-West ..
  100. pmc Global scale variation in the salinity sensitivity of riverine macroinvertebrates: eastern Australia, France, Israel and South Africa
    Ben J Kefford
    Centre for Environmental Sustainability, School of the Environment, University of Technology Sydney, Broadway, New South Wales, Australia
    PLoS ONE 7:e35224. 2012
    ..On this basis it would be possible to screen rivers globally for risk from salinisation...
  101. ncbi Alternative adaptive immunity in invertebrates
    Joachim Kurtz
    ETH Zurich, Institute for Integrative Biology, Experimental Ecology, ETH Zentrum, CHN J12 1, CH 8092 Zurich, Switzerland
    Trends Immunol 27:493-6. 2006
    ..Whether or not invertebrates are capable of a comparable phenotypic plasticity and memory has long been a matter of debate...

Research Grants73

  1. Analysis of the role of the VRK1 protein kinase in mammalian fertility
    Paula Traktman; Fiscal Year: 2011
    ..the VRK1 protein kinase, which is involved in the regulation of cell proliferation in organisms ranging from invertebrates to mammals. The VRK1 orthologs in Drosophila and C...
  2. Neuropeptide modulation of biogenic amine function and aggression in a crustacean
    Maria A Sosa; Fiscal Year: 2013
    ..biogenic amines to behaviors associated with the establishment of social hierarchies in both vertebrates and invertebrates, but the specific mechanisms by which these amines act remain largely unknown...
  3. Development and Regulation of Cholinergic Synapses
    Andres Villu Maricq; Fiscal Year: 2013
    ..Because many of the gene products important for synaptic transmission are conserved from invertebrates to vertebrates, we predict that what we learn from our studies in C...
  4. Insulin, IGF and Insulin Signaling: effects on Anopheles lifespan and immunity
    MICHAEL ALLEN RIEHLE; Fiscal Year: 2012
    ..The insulin/IGF-1 signaling cascade (ISC) has been shown to regulate both innate immunity and lifespan in invertebrates, and could be manipulated to reduce vector competence of mosquitoes...
  5. Role of exogenous melatonin in skin biology
    Andrzej T Slominski; Fiscal Year: 2013
    ..evidence has accumulated that melatonin is widely detectable throughout Nature, being found in vertebrates, invertebrates, plants, unicellular eukaryotes, algae and even bacteria...
  6. A novel and powerful C. elegans behavioral model of addiction
    Eric A Engleman; Fiscal Year: 2013
    ..Basic research with invertebrates has provided ground-breaking discoveries in uncovering the underlying mechanisms of behaviors as complex as ..
  7. The Role of TAF4b in Spermatogonial Stem Cell Maintenance and Self-Renewal
    Eric Gustafson; Fiscal Year: 2013
    ..This new paradigm of germ cell-specific gene regulation is conserved between invertebrates and vertebrates, and may reflect an important mechanism for evolving germ cell-specific modes of gene ..
  8. Novel Model Systems Link Floridean Starch Metabolism to Lafora Disease
    Matthew S Gentry; Fiscal Year: 2010
    ..Animalia with a carbohydrate binding domain, regulates changes in glycogen metabolism in vertebrates and invertebrates. Humans develop insoluble aberrant glycogen particles, called Lafora bodies, as a result of an autosomal ..
  9. CSHL Cell Death Conference
    David J Stewart; Fiscal Year: 2013
    ..Model systems have permitted directed mutagenesis of cell death regulatory genes mammals, invertebrates and lower organisms, demonstrating the role of cell death in a wide range of cellular responses and disease ..
  10. The role of host endogenous small RNAs in innate immunity
    Hailing Jin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Organisms, including mammals, invertebrates, and plants have evolved sophisticated and conserved innate immune responses to protect themselves from pathogen attacks...
  11. Identification of Mammalian Genes Promoting Life Extension
    SIU HUNG CHICK; Fiscal Year: 2013
    ..between increased resistance to stress and extended life span has been extensively demonstrated in invertebrates such as yeast, the fruit fly, and C. elegans...
  12. Unihemispheric sleep: implications for mechanisms of sleep control and function i
    Jerome M Siegel; Fiscal Year: 2013
    ..genetic mechanisms undoubtedly underlie some aspects of the control of sleep- like states in mammals and invertebrates and are being revealed by studies of Drosophila, zebrafish and C. elegans...
  13. Mechanisms underlying loss of neural stem cell competence.
    Minoree Kohwi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In both vertebrates and invertebrates, a vast diversity of neurons is generated from a relatively small pool of neural stem cells that undergo stereotyped temporal transitions to ensure that each ..
  14. Molecular control of tissue morphogenesis
    Jennifer A Zallen; Fiscal Year: 2013
    ..A conserved feature of tissue architecture in vertebrates and invertebrates is a body axis that is elongated from head to tail...
  15. The functional role of DRH-1 in RNAi directed viral immunity
    Rui Lu; Fiscal Year: 2013
    ..RNA interference (RNAi), or RNA silencing, is a novel antiviral mechanism conserved in fungi, plants and invertebrates. RNAi directed viral immunity (RDVI) is a stepwise process that begins with the processing of viral ..
  16. The roles of lipid metabolism in the maintenance of hematopoietic stem cells
    Keisuke Ito; Fiscal Year: 2013
    ..balance control;in stark contrast to what is known about symmetric and asymmetric division of normal cells in invertebrates, it has been extremely difficult to image the division pattern of most purified stem cell compartments in ..
  17. Cellular and molecular mechanisms of aging and regeneration in colonial chordate
    Irving L Weissman; Fiscal Year: 2013
    ..RELEVANCE: In a colonial organism, Botryllus schlosseri, believed to be the link between vertebrates and invertebrates, weekly regeneration of individuals occurs via migration, proliferation, and self renewal by stem cells...
  18. ATP-dependent Chromatin Remodeling in Neural Development
    Gerald R Crabtree; Fiscal Year: 2012
    Studies in both vertebrates and invertebrates have defined signaling pathways, such as Notch, Wnt and BMP as well as transcription factors such as the HLH and Sox families that are essential for neurogenesis and neural differentiation...
  19. Lectin-Carbohydrate Interactions in the Host-Parasite System
    Xiao Qiang Yu; Fiscal Year: 2010
    ..lectins are a family of proteins with functions as PRRs in innate immune systems of vertebrates and invertebrates. This project is to investigate how selective binding of host proteins to parasites determines the fate of ..
    ..The role of Nrg/L1 in these developmental processes has been well-characterized in vertebrates and invertebrates but much less is known about potential functions during synapse formation...
  21. Molecular mechanisms of axon guidance and neural connectivity
    Jonathan R Terman; Fiscal Year: 2013
    ..Semaphorins are phylogenetically conserved secreted and transmembrane proteins found in invertebrates and in vertebrates...
  22. Transcriptome resources for a cephalopod model system
    Clifton W Ragsdale; Fiscal Year: 2013
    ..include squids and octopuses, are the largest non-mammalian organisms and have the largest brains among all invertebrates. They also have a cellular pattern of early embryogenesis that is strikingly similar to that of vertebrates...
  23. Gene silencing as an antiviral defense in animal cells
    Shou Wei Ding; Fiscal Year: 2013
    ..In plants and invertebrates, replication of RNA viruses triggers Dicer-dependent biogenesis of virus-derived small interfering RNAs (..
  24. The translational program in oocyte and early embryo development
    Marco Conti; Fiscal Year: 2013
    ..RNA binding proteins Dazl and Pumilio2, critical for germ line development and maintenance of pluripotency in invertebrates. The hypothesis tested is that these RNA regulators play a critical function during early embryo development ..
  25. Development of a zebrafish assay for the identification of ALS drug targets
    Christine E Beattie; Fiscal Year: 2010
    ..Since SOD1 mutants do not cause ALS-like phenotypes in invertebrates, only rodent models of this disease exist thus limiting the type of experiments that can be performed...
  26. Control of Alcohol Responses by Actin-Regulating Genes
    Adrian Rothenfluh; Fiscal Year: 2013
    ..and some are known to participate in complex behaviors such as learning and memory, in vertebrates and invertebrates. We predict that these pathways are also functionally conserved in their regulation of ethanol-induced ..
  27. Comparative Biology of Tissue Repair, Regeneration and Aging
    Kevin Strange; Fiscal Year: 2013
    ..However, robust regeneration is the norm for countless lower vertebrates and invertebrates. In addition, nature has endowed diverse animals with remarkable longevity and robust tissue repair mechanisms ..
  28. Clavulanic acid: a potential abuse-deterrent and CNS-active therapeutic
    Scott M Rawls; Fiscal Year: 2012
    ..analgesic tolerance and cocaine self-administration in rodents and display anti-seizure-like activity in invertebrates. The Specific Aims are to: 1) Compare the effects of CLAV and CTX in animal models of tolerance, dependence, ..
    NISSI MARY VARKI; Fiscal Year: 2012 explored in the intact organism - and this complexity of mammalian glycans is not well represented in model invertebrates. Thus, the central theme of this proposal is state-of-the-art genetic manipulation of Sias, GAG chains, and ..
  30. 2011 Antimicrobial Peptides Gordon Research Conference
    Nita H Salzman; Fiscal Year: 2011
    ..AMPs are endogenous components of innate immunity used by all metazoans including bacteria, fungi, plants, invertebrates, vertebrates, and mammals including humans...
  31. Role of Ed in regulating EGFR and Notch signaling during retinal development
    Susan A Spencer; Fiscal Year: 2010
    ..In the developing retinas of both vertebrates and invertebrates, EGFR and Notch control proliferation of retinal precursors and differentiation of photoreceptors and support ..
  32. ERV3 Control of Human Placentation
    NEAL STEWART ROTE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The genome of most vertebrates and some invertebrates has been transformed over millions of years by the integration of infectious retroviruses...
  33. Hydra: New Models for Aging Research
    Steven N Austad; Fiscal Year: 2013
    ..capable of modulating aging over the past two decades is largely due to the use by biogerontologists of model invertebrates (worms, and flies) that are easily mass cultured in the laboratory, short-lived, easily manipulated and ..
  34. Molecular Mechanisms of Protochordate Allorecognition
    Anthony W De Tomaso; Fiscal Year: 2013
    ..larva and later metamorphoses to an invertebrate adult, and represents the evolutionary transition between invertebrates and vertebrates. B...
  35. 2013 Antimicrobial Peptides GRC/GRS
    Gill Diamond; Fiscal Year: 2013
    ..AMPs are endogenous components of innate immunity used by all metazoans including bacteria, fungi, plants, invertebrates, vertebrates, and mammals including humans...
  36. 4E-BP Dependent Secreted Proteins from Human and Fly Skeletal Muscle
    MATTHEW JAMES LAYE; Fiscal Year: 2013
    ..We also hypothesize that effects of 4E-BP on muscle are conserved between invertebrates and mammals...
  37. Central Nervous System Autoimmunity and Immunoregulation in the Zebrafish
    Francisco J Quintana; Fiscal Year: 2011
    ..Worms and flies have been useful in the identification of the mechanisms governing innate immunity, but invertebrates do not have T{reg}...
  38. TOR, Translation and Aging
    Brian K Kennedy; Fiscal Year: 2013
    ..Consistently, reduced TOR signaling or S6 kinase activity leads to increased lifespan in both invertebrates, and delays the onset of age-related diseases in mammals...
  39. FoxO phosphorylation in the control of C. elegans lifespan
    Patrick J Hu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): FoxO transcription factors control aging in invertebrates, and FoxO polymorphisms are associated with extreme longevity in multiple independent cohorts of long-lived humans...
  40. Analysis of Ret signaling in Drosophila enteric nervous system development.
    Thomas Kidd; Fiscal Year: 2011
    ..There is a remarkable conservation of molecular function between invertebrates and humans, so we believe our results will be relevant to HSCR in humans...
  41. Innate immune regulation of inflammation and adaptive immunity
    Anthony L DeFranco; Fiscal Year: 2012
    ..Finally, in Project #4, Dr. Locksley will determine how chitin, a polysaccharide found in fungi and invertebrates, promotes type 2 immunity and how it interacts with TLR signaling pathways to regulate the type of immune ..
  42. Enzymatic and motor properties of myosin III
    Christopher M Yengo; Fiscal Year: 2012
    ..gene results in deafness in vertebrates as well as retinal degeneneration and phototransduction defects in invertebrates. Myosin III is an actin-based molecular motor that contains a conserved motor domain characteristic of the ..
  43. Interdisciplinary Training in Transplantation Biology
    Angus W Thomson; Fiscal Year: 2013
    ..A unique feature of the Training Program is that investigations range from those in invertebrates and rodents to non-human primates and humans...
    Paul D Friesen; Fiscal Year: 2010
    ..components of the human cell death pathway are conserved with those of less complex organisms, including invertebrates. As such, studies using model insects, including Drosophila melanogaster, have provided fundamental advances ..
  45. Molecular Mechanisms of Semaphorin/Plexin-mediated Cytoskeletal Reorganization
    Jonathan R Terman; Fiscal Year: 2013
    ..There is one MICAL gene in invertebrates and three MICAL genes in mammals and they control axon guidance, synaptogenesis, dendritic pruning, and other ..
  46. New Leads Against Cancer and Infectious Diseases from Puerto Rican Reef Species
    Abimael D Rodriguez; Fiscal Year: 2013
    ..Marine invertebrates have been identified for a long time as likely sources of new biomedicinal substances...
  47. Structural biology of neurotransmitter ion channels
    James E Gouaux; Fiscal Year: 2013
    ..a super family of receptors that includes those for 3-amino butyric acid (GABA), glycine, serotonin and, in invertebrates, for glutamate...
  48. Probing functions of NAM and NAD+ salvage in development and aging in C. elegans
    Wendy Hanna-Rose; Fiscal Year: 2013
    ..The first enzyme in the salvage pathway for NAD+ biosynthesis in invertebrates is nicotinamidase, which converts nicotinamide to nicotinic acid. C...
  49. The Role of Muller Cells in Visual Pigment Regeneration
    Gabriel H Travis; Fiscal Year: 2013
    ..It has been known for some time that insects and other invertebrates regenerate their visual pigments using light energy...
  50. The role of Drosophila CrebA in ethanol tolerance
    BENJAMIN R TROUTWINE; Fiscal Year: 2012
    ..In invertebrates and mammals CREB has been shown to be involved in learning and memory, depression, anxiety, circadian rhythms ..
  51. The Wingless transduction pathway in synapse development
    VIVIAN G BUDNIK; Fiscal Year: 2013
    ..Studies in both vertebrates and invertebrates have identified a signaling mechanism, mediated by the secreted protein Wnt/Wingless, which plays key roles in ..
  52. Molecular Mechanisms of Ataxin-1 Action
    Chih Cheng Tsai; Fiscal Year: 2010
    ..SMRT/SMRTER-dependent regulatory pathways is partly responsible for its cytotoxicity in both vertebrates and invertebrates. Because both SMRT and SMRTER are nuclear receptor co-repressors, this proposal probes whether Atx1-mediated ..
  53. IGF-I Signaling and Aging
    Martin L Adamo; Fiscal Year: 2011
    ..would be seminal since it shows that the increased life span and resistance to oxidative stress observed in invertebrates models with reduced insulin/IGF-l signaling extends to mammals...
  54. Analysis of Cis-Regulatory Mechanisms in Drosophila CNS Midline Genes
    JOSEPH CARLISLE PEARSON; Fiscal Year: 2011
    ..As many regulatory networks, including those used in the CNS, are shared between invertebrates and vertebrates, insight into these networks will have profound implications in vertebrates...
  55. Insoluble protein carbonyl: A critical determinant for mammalian longevity
    Asish R Chaudhuri; Fiscal Year: 2013
    ..changes in protein, particularly protein carbonylation, occur with increasing age in animals ranging from invertebrates, e.g., yeast and Drosophila, to humans...
  56. Training Program in Mental Health Research
    Matthew L Shapiro; Fiscal Year: 2013
    ..At Mount Sinai, the nervous system is studied in diverse model systems, from 'simple'invertebrates such as the sea snail Aplysia, the fruit fly, or the worm C...
  57. The Regulation of Smoothened in Hedgehog Signaling
    Jianhang Jia; Fiscal Year: 2012 applicant): The hedgehog (hh) family members control many aspects of development in both vertebrates and invertebrates. Hh signaling is associated with important biological phenomena such as patterning, cell growth, and ..
  58. Mechanisms Underlying Muscle Development in Drosophila
    ERIKA RAE GEISBRECHT; Fiscal Year: 2013
    ..many features concerning MTJ formation, structure, and function are conserved between both vertebrates and invertebrates, studies in the genetically tractable organism Drosophila melanogaster have proven instrumental in uncovering ..
  59. Role of RNA silencing as an antiviral defense mechanism in fungi
    Donald L Nuss; Fiscal Year: 2013
    ..RNA silencing has also been shown to serve as an antivrial defense mechanism in plants, invertebrates, and fungi and to modulate animal virus infections...
  60. Transcriptional Control of Hematopoiesis
    BARBARA LYNNE KEE; Fiscal Year: 2013
    ..The E protein transcription factors are essential regulators of cell fate in vertebrates and invertebrates and interact with multiple proteins implicated in hematopoietic stem cell (HSC) development and function...
  61. Specification of Dermal Papilla Cell Fate in the Hair Follicle Stem Cell Niche
    Michael Rendl; Fiscal Year: 2013
    ..While much knowledge has been gained from studies in invertebrates, a molecular understanding of how niche cells in mammalian SC niches, such as the bone marrow, brain, ..
  62. Studies on RNAi Based Delivery in Vivo
    Mark A Kay; Fiscal Year: 2013
    ..One group of these RNAs may be involved in RNA-directed RNA transcription, a process known to be robust in invertebrates and plants but not previously believed to exist in mammals...
    JOHN MARCHALONIS; Fiscal Year: 1993
    Long lived invertebrates are immunoincompetent in the sense that they lack the classical T and B cell arms of the immune system but they respond successfully to challenge with micro-organisms by inflammatory mechanisms involving ..
  64. The role of cannabinoid signaling in the nematode Caenorhabditis elegans
    MATTHEW SIMON GILL; Fiscal Year: 2010
    ..Cannabinoid receptors have been identified in many different species, including some invertebrates, but they have not been identified in the nematode Caenorhabditis elegans. In C...
  65. Genomic Approaches to Neuronal Diversity and Plasticity
    Jingyue Ju; Fiscal Year: 2007 study how genes regulate cellular and organism behavior on the scale from simpler nervous systems in invertebrates to the human brain...
  66. Immune Response of Drosophila Against Spiroplasma
    Mariana Mateos; Fiscal Year: 2009
    ..Innate defense mechanisms of invertebrates and vertebrates show striking similarities and are evolutionary conserved...
    DAVID YAGER; Fiscal Year: 2004
    ..since the fundamental structures of auditory receptors and ears are remarkably similar in vertebrates and invertebrates. Further, hearing has evolved many times in insects (greater than 14 compared with less than 3 in vertebrates) ..
  68. Microsporidiosis:A Therapeutic Target
    Louis Weiss; Fiscal Year: 2003
    ..are ubiquitous in nature and infections have been described in all classes of vertebrates as well as in most invertebrates. They are important agricultural parasites in commercially significant insects, fish, laboratory rodents, ..
    Judy Lieberman; Fiscal Year: 2007
    ..RNAi) is a powerful mechanism of post-transcriptional gene silencing originally described in plants and invertebrates as part of an ancient defense for protection against viruses and genetic damage from transposable elements...
    Tadeusz F Molinski; Fiscal Year: 2010
    ..Natural products are represented among clinically useful antifungal agents. Marine invertebrates, particularly Porifera (sponges), produce chemically diverse libraries of natural products, some of which ..
  71. D1-like dopamine receptors in learning and behavior
    JULIE MUSTARD; Fiscal Year: 2005
    ..Dopamine is found throughout the animal kingdom, and studies on invertebrates suggest that many of its functions are highly conserved...
  72. HCO3-transporters in Drosophila and Mosquitoes
    MICHAEL ROMERO; Fiscal Year: 2003
    ..the past 4 years, we and others have uncovered 7-8 groups of new HCO3-transporters in plants, vertebrates and invertebrates. Recently we have cloned a Na+-driven anion exchangers (NDAE1) from Drosophila and immunolocalized NDAE1 to ..
  73. Developmental analysis of SELCT proteins
    ANNE CHURCH HART; Fiscal Year: 2010
    ..pathway is critical for cell fate specification and lateral inhibition during development in vertebrates and invertebrates. Notch receptors bind extracellular ligands (e.g...