wistar rats

Summary

Summary: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.

Top Publications

  1. pmc Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex
    Carl C H Petersen
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg D 69120, Germany
    Proc Natl Acad Sci U S A 100:13638-43. 2003
  2. ncbi Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    T Sakurai
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 92:573-85. 1998
  3. pmc Initiation and execution of lipotoxic ER stress in pancreatic beta-cells
    Daniel A Cunha
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    J Cell Sci 121:2308-18. 2008
  4. pmc Intermittent access to 20% ethanol induces high ethanol consumption in Long-Evans and Wistar rats
    Jeffrey A Simms
    Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California 94608, USA
    Alcohol Clin Exp Res 32:1816-23. 2008
  5. ncbi Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
    T Tikka
    A. I. Virtanen Institute for Molecular Sciences, University of Kuopio, FIN-70211 Kuopio, Finland
    J Neurosci 21:2580-8. 2001
  6. pmc The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
    Armin Schneider
    Axaron Bioscience AG, Heidelberg, Germany
    J Clin Invest 115:2083-98. 2005
  7. pmc Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism
    Michelle Welsh
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Invest 118:1479-90. 2008
  8. ncbi Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress
    Ilham Kharroubi
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808 CP 618, B 1070 Brussels, Belgium
    Endocrinology 145:5087-96. 2004
  9. ncbi Gut hormone PYY(3-36) physiologically inhibits food intake
    Rachel L Batterham
    Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Nature 418:650-4. 2002
  10. ncbi Neonatal leptin treatment reverses developmental programming
    M H Vickers
    Liggins Institute, Faculty of Medical and Health Science, University of Auckland and National Research Centre for Growth and Development, Auckland 1020, New Zealand
    Endocrinology 146:4211-6. 2005

Detail Information

Publications383 found, 100 shown here

  1. pmc Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex
    Carl C H Petersen
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg D 69120, Germany
    Proc Natl Acad Sci U S A 100:13638-43. 2003
    ..The ongoing spontaneous activity thus regulates the amplitude and the time-dependent spread of the sensory response in layer 2/3 barrel cortex...
  2. ncbi Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    T Sakurai
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 92:573-85. 1998
    ..prepro-orexin mRNA level is up-regulated upon fasting, suggesting a physiological role for the peptides as mediators in the central feedback mechanism that regulates feeding behavior...
  3. pmc Initiation and execution of lipotoxic ER stress in pancreatic beta-cells
    Daniel A Cunha
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    J Cell Sci 121:2308-18. 2008
    ..In conclusion, saturated FFA induce ER stress via ER Ca(2+) depletion. The IRE1 and resulting JNK activation contribute to beta-cell apoptosis. PERK activation by palmitate also contributes to beta-cell apoptosis via CHOP...
  4. pmc Intermittent access to 20% ethanol induces high ethanol consumption in Long-Evans and Wistar rats
    Jeffrey A Simms
    Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California 94608, USA
    Alcohol Clin Exp Res 32:1816-23. 2008
    ..In this study, we have further characterized this drinking model...
  5. ncbi Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
    T Tikka
    A. I. Virtanen Institute for Molecular Sciences, University of Kuopio, FIN-70211 Kuopio, Finland
    J Neurosci 21:2580-8. 2001
    ..These findings indicate that the proliferation and activation of microglia contributes to excitotoxicity, which is inhibited by minocycline, an antibiotic used in severe human infections...
  6. pmc The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
    Armin Schneider
    Axaron Bioscience AG, Heidelberg, Germany
    J Clin Invest 115:2083-98. 2005
    ..We therefore propose G-CSF as a potential new drug for stroke and neurodegenerative diseases...
  7. pmc Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism
    Michelle Welsh
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Invest 118:1479-90. 2008
    ..Based on the timings in rats, we believe the programming window in humans is likely to be 8-14 weeks of gestation...
  8. ncbi Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress
    Ilham Kharroubi
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808 CP 618, B 1070 Brussels, Belgium
    Endocrinology 145:5087-96. 2004
    ..Our results argue against a unifying hypothesis for the mechanisms of beta-cell death in T1DM and T2DM...
  9. ncbi Gut hormone PYY(3-36) physiologically inhibits food intake
    Rachel L Batterham
    Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Nature 418:650-4. 2002
    ..Thus, postprandial elevation of PYY(3-36) may act through the arcuate nucleus Y2R to inhibit feeding in a gut-hypothalamic pathway...
  10. ncbi Neonatal leptin treatment reverses developmental programming
    M H Vickers
    Liggins Institute, Faculty of Medical and Health Science, University of Auckland and National Research Centre for Growth and Development, Auckland 1020, New Zealand
    Endocrinology 146:4211-6. 2005
    ..The complete normalization of the programmed phenotype by neonatal leptin treatment implies that leptin has effects that reverse the prenatal adaptations resulting from relative fetal undernutrition...
  11. ncbi Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain
    G A Rosenberg
    Departments of Neurology, Cell Biology and Physiology, and Neuroscience, University of New Mexico, Albuquerque, NM 87131, USA
    Stroke 29:2189-95. 1998
    ..Therefore, we measured blood-brain barrier (BBB) permeability, brain water and electrolytes, MMPs, and TIMPs at multiple times after reperfusion...
  12. ncbi Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia
    T M Tikka
    A. I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    J Immunol 166:7527-33. 2001
    ..Together, these results suggest that microglial activation contributes to NMDA excitotoxicity and that minocycline, a tetracycline derivative, represents a potential therapeutic agent for brain diseases...
  13. ncbi Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring
    Karen A Lillycrop
    Development and Cell Biology, University of Southampton, UK
    J Nutr 135:1382-6. 2005
    ..Epigenetic regulation of gene transcription provides a strong candidate mechanism for fetal programming...
  14. pmc Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex
    Satoshi Ikemoto
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Brain Res Rev 56:27-78. 2007
    ....
  15. ncbi Perisomatic feedback inhibition underlies cholinergically induced fast network oscillations in the rat hippocampus in vitro
    Edward O Mann
    University Laboratory of Physiology, Oxford University, Parks Road, Oxford OX1 3PT, UK
    Neuron 45:105-17. 2005
    ..AMPA receptor-mediated recurrent excitation was necessary for the synchronization of interneuronal discharge, which strongly supports a synaptic feedback model for the generation of hippocampal gamma oscillations...
  16. pmc Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain
    Anna K Clark
    Novartis Institutes for BioMedical Research, London WC1E 6BS, United Kingdom
    Proc Natl Acad Sci U S A 104:10655-60. 2007
    ....
  17. ncbi Garlic ameliorates gentamicin nephrotoxicity: relation to antioxidant enzymes
    J Pedraza-Chaverri
    Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico UNAM, 04510, Distrito Federal, Mexico
    Free Radic Biol Med 29:602-11. 2000
    ..CAT mRNA levels decreased in the GM group. The protective effect of garlic is associated with the prevention of the decrease of Mn-SOD and GPx activities and with the rise of lipoperoxidation in renal cortex...
  18. ncbi Microglia provide neuroprotection after ischemia
    Jens Neumann
    Leibniz Institute for Neurobiology, Project Group Neuropharmacology, Magdeburg, Germany
    FASEB J 20:714-6. 2006
    ..quot; In acute injury such as trauma or stroke, appropriately activated microglia may primarily have a neuroprotective role. Anti-inflammatory treatment within the protective time window of microglia would therefore be counterintuitive...
  19. ncbi Somatosensory cortical neuronal population activity across states of anaesthesia
    Irina A Erchova
    Cognitive Neuroscience Sector, International School for Advanced Studies, Via Beirut, 9, 34014 Trieste, Italy
    Eur J Neurosci 15:744-52. 2002
    ..The possible significance of the cyclic cortical responsiveness encountered during urethane anaesthesia to cortical processing in awake rats is considered...
  20. ncbi Critical involvement of dopaminergic neurotransmission in impulsive decision making
    Marcel M van Gaalen
    Department of Medical Pharmacology, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, Free University Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 60:66-73. 2006
    ..Commonly prescribed for this condition, amphetamine (Adderall), reduces impulsive decision making; however, the neuropharmacologic mechanism of this effect of amphetamine is unclear...
  21. ncbi Spike timing of distinct types of GABAergic interneuron during hippocampal gamma oscillations in vitro
    Norbert Hajos
    Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H 1450, Hungary
    J Neurosci 24:9127-37. 2004
    ....
  22. ncbi Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo
    Yugo Fukazawa
    Mitsubishi Kagaku Institute of Life Sciences MITILS, Machida, 194 8511, Tokyo, Japan
    Neuron 38:447-60. 2003
    ..These observations suggest that mechanisms regulating the spine actin cytoskeleton contribute to the persistence of LTP...
  23. ncbi GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress
    Bernardo Yusta
    Department of Medicine, Banting and Best Diabetes Centre, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Cell Metab 4:391-406. 2006
    ..These findings demonstrate that GLP-1R signaling directly modulates the ER stress response leading to promotion of beta cell adaptation and survival...
  24. pmc Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide
    V Vellani
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QJ, UK
    J Physiol 534:813-25. 2001
    ..The results are consistent with a model in which phosphorylation of VR1 by PKC increases the probability of channel gating by agonists, and in which dephosphorylation occurs by a calcium-dependent process...
  25. ncbi Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression
    Neal Lemon
    Learning and Memory Research, Medical Faculty, and International Graduate School for Neuroscience, Ruhr University Bochum, 44780 Bochum, Germany
    J Neurosci 26:7723-9. 2006
    ..These findings suggest that the dopaminergic system, acting via D1/D5 receptors, gates long-term changes in synaptic strength and that these changes are a critical factor in the acquisition of novel information...
  26. pmc Dynamic representation of whisker deflection by synaptic potentials in spiny stellate and pyramidal cells in the barrels and septa of layer 4 rat somatosensory cortex
    Michael Brecht
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Heidelberg, Germany
    J Physiol 543:49-70. 2002
    ..This presumably reflects the divergence of thalamocortical projections to different barrels. Septum cell PSPs preferably represent multiple whisker deflections, but less dynamically and with less spatial acuity...
  27. ncbi The expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in neurochemically defined axonal populations in the rat spinal cord with emphasis on the dorsal horn
    A J Todd
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Eur J Neurosci 17:13-27. 2003
    ..As all primary afferents are thought to be glutamatergic, this raises the possibility that unmyelinated afferents, most of which are nociceptors, express a different vesicular glutamate transporter...
  28. ncbi Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor
    Jean Buteau
    Molecular Nutrition Unit, Departments of Nutrition and Biochemistry, University of Montreal, the Centre de Recherche du CHUM and Institut du Cancer, Montreal, Quebec, Canada
    Diabetes 52:124-32. 2003
    ....
  29. pmc Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex
    H Markram
    Max Planck Institut fur medizinische Forschung, Abteilung Zellphysiologie, Germany
    J Physiol 500:409-40. 1997
    ..neurones, which have their synaptic contacts preferentially located on basal and apical oblique dendrites, was due to differences in transmitter release probability of the projecting neurones and, to a lesser extent, to differenc..
  30. ncbi The presence and role of the tetrodotoxin-resistant sodium channel Na(v)1.9 (NaN) in nociceptive primary afferent neurons
    Xin Fang
    Department of Physiology, University of Bristol, Medical School, Bristol BS8 1TD, United Kingdom
    J Neurosci 22:7425-33. 2002
    ..9 (NaN). Intracellular recordings in lumbar DRGs in Wistar rats enabled units with dorsal root C-, Adelta-, or Aalpha/beta-fibers to be classified as nociceptive, low-..
  31. ncbi Defective intracellular Ca(2+) signaling contributes to cardiomyopathy in Type 1 diabetic rats
    Kin M Choi
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, Ohio 45267, USA
    Am J Physiol Heart Circ Physiol 283:H1398-408. 2002
    ..The increase in phospholamban, decrease in Na(+)/Ca(2+) exchanger, and unchanged L-type Ca(2+) channel activity in this model of diabetic cardiomyopathy are distinct from other types of cardiomyopathy...
  32. pmc Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats
    Jose R Pauli
    Departamento de Clinica Medica, FCM UNICAMP, Universidade Estadual de Campinas, Campinas, SP, Brasil
    J Physiol 586:659-71. 2008
    ..These results provide new insights into the mechanism by which exercise restores insulin sensitivity...
  33. pmc Target cell-specific modulation of neuronal activity by astrocytes
    A S Kozlov
    Institut National de la Santé et de la Recherche Médicale corrected U603, Paris, F 75006 corrected France
    Proc Natl Acad Sci U S A 103:10058-63. 2006
    ..Thus, by releasing excitatory and inhibitory neurotransmitters, astrocytes exert a complex modulatory control on the olfactory network...
  34. ncbi High multivitamin intake by Wistar rats during pregnancy results in increased food intake and components of the metabolic syndrome in male offspring
    Ignatius M Y Szeto
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College St, Rm 322, Toronto, ON, Canada M5S 3E2
    Am J Physiol Regul Integr Comp Physiol 295:R575-82. 2008
    ..Pregnant Wistar rats (n=10 per group) were fed the AIN-93G diet with the recommended vitamin (RV) content or a 10-fold increase [..
  35. ncbi Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats
    Srinivasan Kalayarasan
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamil Nadu, India
    Eur J Pharmacol 606:162-71. 2009
    ..factor E2-related factor 2 (Nrf2) in inducing antioxidants and phase II enzymes during gentamicin toxicity in Wistar rats. DAS was administered intraperitoneally at a dosage of 150 mg/kg body weight once daily for 6 days...
  36. ncbi Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors
    Laiche Djouhri
    Department of Physiology, Medical School, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 26:1281-92. 2006
    ..Overall, SFL was related to SA rate in intact C-nociceptors. Both L5 degeneration and chromic gut cause inflammation. Therefore, both SA and SFL/spontaneous pain after nerve injury (mSNA) may result from cumulative neuroinflammation...
  37. ncbi Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols
    Rodrigo Ferreira de Moura
    Physical Education Department, Sao Paulo State University UNESP, Avenida 24 A, 1515 Bela Vista, 13506 900 Rio Claro, SP, Brazil
    Br J Nutr 101:1178-84. 2009
    In search of an adequate model for the human metabolic syndrome, the metabolic characteristics of Wistar rats were analysed after being submitted to different protocols of high fructose ingestion...
  38. ncbi P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
    Makoto Tsuda
    Division of Biosignaling, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya, Tokyo 158 8501, Japan
    Nature 424:778-83. 2003
    ..Thus, blocking P2X4Rs in microglia might be a new therapeutic strategy for pain induced by nerve injury...
  39. pmc A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity
    Yoshito Tanaka
    Pacific Northwest Research Institute and the Department of Medicine, University of Washington, Seattle, WA, 98122, USA
    Proc Natl Acad Sci U S A 99:12363-8. 2002
    ..These observations support the hypothesis that oxidative stress is one mechanism for glucose toxicity in pancreatic islets...
  40. ncbi Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
    Christoph Schmidt-Hieber
    Physiologisches Institut der Universität Freiburg, D 79104 Freiburg, Germany
    Nature 429:184-7. 2004
    ..Thus, newly generated neurons express unique mechanisms to facilitate synaptic plasticity, which may be important for the formation of new memories...
  41. ncbi Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors
    Tommaso Fellin
    Istituto CNR di Neuroscienze, Universita di Padova, Viale G Colombo 3, 35121, Italy
    Neuron 43:729-43. 2004
    ..Our results reveal a distinct mechanism for neuronal excitation and synchrony and highlight a functional link between astrocytic glutamate and extrasynaptic NMDA receptors...
  42. ncbi Pivotal role of nitric oxide in the control of blood pressure after leptin administration
    G Fruhbeck
    Department of Endocrinology, Clinica Universitaria de Navarra, University of Navarra, Pamplona, Spain
    Diabetes 48:903-8. 1999
    ..or vehicle on blood pressure (BP), heart rate (HR), and serum nitrite/nitrate concentrations of anesthetized Wistar rats was examined. At 90 min after injection, the three leptin doses tested increased serum NO concentrations 20...
  43. ncbi Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs
    H Markram
    Max Planck Institut fur medizinische Forschung, Abteilung Zellphysiologie, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Science 275:213-5. 1997
    ..These observations suggest that APs propagating back into dendrites serve to modify single active synaptic connections, depending on the pattern of electrical activity in the pre- and postsynaptic neurons...
  44. pmc Circadian control of the daily plasma glucose rhythm: an interplay of GABA and glutamate
    Andries Kalsbeek
    Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    PLoS ONE 3:e3194. 2008
    ....
  45. ncbi A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo
    M Rossi
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Endocrinology 139:4428-31. 1998
    ..In conclusion, Agrp(83-132) administered i.c.v. increases feeding with long lasting effects and is able to inhibit the action of alphaMSH. This interaction may be mediated by the MC3-R and/or MC4-R...
  46. ncbi Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats
    D A Slattery
    Department of Molecular and Behavioural Neuroendocrinology, University of Regensburg, Regensburg, Germany
    Neuropharmacology 58:56-61. 2010
    ..b>Wistar rats selectively bred for high (HAB) and low (LAB) anxiety-related behaviour, respectively, have been shown to ..
  47. ncbi Synaptic distribution of the NR1, NR2A and NR2B subunits of the N-methyl-d-aspartate receptor in the rat lumbar spinal cord revealed with an antigen-unmasking technique
    Gergely G Nagy
    Spinal Cord Group, West Medical Building, Institute of Biomedical and Life Sciences, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK
    Eur J Neurosci 20:3301-12. 2004
    ..These results suggest that many, but not all, glutamatergic synapses in the spinal cord possess NMDA receptors and that subunit composition varies in different regions...
  48. ncbi Anatomical, physiological, molecular and circuit properties of nest basket cells in the developing somatosensory cortex
    Yun Wang
    Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06520 8001, USA
    Cereb Cortex 12:395-410. 2002
    ..These data provide multiparametric distinguishing features of three major subclasses of basket cells and indicate that NBCs are powerful interneurons that provide most of the (peri-)somatic inhibition in the supragranular layers...
  49. pmc Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart
    Yuichi Tomita
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    J Cell Biol 170:1135-46. 2005
    ....
  50. ncbi Critical period and minimum single oral dose of ochratoxin A for inducing developmental toxicity in pregnant Wistar rats
    Rajendra D Patil
    Division of Pathology, Indian Veterinary Research Institute, Izatnagar 243 122, Uttar Pradesh, India
    Reprod Toxicol 22:679-87. 2006
    ..was conducted to determine critical dose and critical time for the developmental toxicity of OTA in pregnant Wistar rats after single oral dose administration...
  51. ncbi Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats
    Elisabeth Wenzel
    German Research Center for Food Chemistry, Garching, Germany
    Mol Nutr Food Res 49:482-94. 2005
    ..The lack of effect on the chemopreventive parameters is probably due to the formation of various resveratrol conjugates reducing its bioavailability in the rat...
  52. pmc Western diet, but not high fat diet, causes derangements of fatty acid metabolism and contractile dysfunction in the heart of Wistar rats
    Christopher R Wilson
    Department of Internal Medicine, Division of Cardiology, University of Texas Medical School at Houston, University of Texas Health Science Center at Houston, 6431 Fannin, MSB 1 246, Houston, TX 77030, USA
    Biochem J 406:457-67. 2007
    ..b>Wistar rats were fed on low fat, 'Western' or high fat (10, 45 or 60% calories from fat respectively) diet for acute (1 day ..
  53. ncbi p16 hypermethylation during gastric carcinogenesis of Wistar rats by N-methyl-N'-nitro-N-nitrosoguanidine
    Hua Bai
    Department of Cancer Etiology, Peking University Health Science Center and Beijing Institute for Cancer Research, Da Hong Luo Chang Street, Western District, Beijing 100034, China
    Mutat Res 535:73-8. 2003
    ..The frequency and timing of p16 hypermethylation during the multistep gastric carcinogenesis in Wistar rats were analyzed in various microdissected gastric lesions...
  54. ncbi Behavioral profiles and stress-induced corticosteroid secretion in male Wistar rats subjected to short and prolonged periods of maternal separation
    Erika Roman
    Department of Pharmaceutical Biosciences, Division of Pharmacology, Uppsala University, P O Box 591, SE 751 24 Uppsala, Sweden
    Horm Behav 50:736-47. 2006
    ..In contrast to previous results, the outcome of the present investigation does not support the notion that a prolonged period of maternal separation results in an adult phenotype characterized by an increased emotional reactivity...
  55. pmc Epigallocatechin, a green tea polyphenol, attenuates myocardial ischemia reperfusion injury in rats
    Rajesh Aneja
    Department of Pediatrics, Division of Critical Care Medicine OSB5, Cincinnati Children s Hospital Medical Center and College of Medicine, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Mol Med 10:55-62. 2004
    ..Male Wistar rats were subjected to myocardial ischemia (30 min) and reperfusion (up to 2 h)...
  56. ncbi Chronic caffeine treatment attenuates experimental autoimmune encephalomyelitis induced by guinea pig spinal cord homogenates in Wistar rats
    Guo Qian Chen
    Department of Neurology, the First Affiliated Hospital and Research Institute of Experimental Neurobiology, Wenzhou Medical College, Wenzhou, Zhejiang, PR China
    Brain Res 1309:116-25. 2010
    ....
  57. pmc Importance of ERK1/2 in upregulation of endothelin type B receptors in cerebral arteries
    Marie Henriksson
    Division of Experimental Vascular Research, Department of Medicine, Lund University, Lund, Sweden
    Br J Pharmacol 142:1155-61. 2004
    ..Since there is a similar upregulation in models of focal ischaemia and subarachnoid haemorrhage, this may be an important pathophysiological event...
  58. ncbi Encoding of whisker vibration by rat barrel cortex neurons: implications for texture discrimination
    Ehsan Arabzadeh
    Cognitive Neuroscience Sector, International School for Advanced Studies, 34014 Trieste, Italy
    J Neurosci 23:9146-54. 2003
    ..We conclude that vibration kinetics are rapidly and reliably encoded in the firing rate of cortical ensembles. Therefore, the cortical representation of vibration speed could underlie texture discrimination...
  59. ncbi A 90-day safety study of genetically modified rice expressing Cry1Ab protein (Bacillus thuringiensis toxin) in Wistar rats
    Malene Schrøder
    Department of Toxicology and Risk Assessment, Danish Institute for Food and Veterinary Research, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Food Chem Toxicol 45:339-49. 2007
    ..In a 90-day feeding study on Wistar rats, the transgenic KMD1 rice expressing Cry1Ab protein was compared to its non-transgenic parental wild type, ..
  60. ncbi Immunotoxicological studies of genetically modified rice expressing PHA-E lectin or Bt toxin in Wistar rats
    Stine Kroghsbo
    Department of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Toxicology 245:24-34. 2008
    ..from kidney bean (Phaseolus vulgaris erythroagglutinin) was examined in 28- and 90-day feeding studies in Wistar rats. PHA-E lectin was chosen as positive control...
  61. ncbi Intraventricular infusions of anti-NCAM PSA impair the process of consolidation of both avoidance conditioning and spatial learning paradigms in Wistar rats
    C M Seymour
    School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Neuroscience 157:813-20. 2008
    ..in the consolidation of two commonly used behavioral paradigms: avoidance conditioning and spatial learning in Wistar rats. Anti-PSA was found to significantly induce amnesia of the passive avoidance response when infused at the 10 h ..
  62. pmc Dynamic receptive fields of reconstructed pyramidal cells in layers 3 and 2 of rat somatosensory barrel cortex
    Michael Brecht
    Department of Cell Physiology, Max Planck Institute for Medical Research, Heidelberg, Germany
    J Physiol 553:243-65. 2003
    ..We conclude that the lemniscal (barrel-related) and paralemniscal (septum-related) afferent inputs remain anatomically and functionally segregated in L2/3...
  63. ncbi Involvement of dopamine D1 and D2 receptors in the nucleus accumbens core and shell in inhibitory response control
    Tommy Pattij
    Department of Anatomy and Neurosciences, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, VU Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 191:587-98. 2007
    ..Impaired inhibitory control over behavior is a key feature in various psychiatric disorders, and recent studies indicated an important role for dopamine D(1) and D(2) receptors and the nucleus accumbens (Acb) in this respect...
  64. pmc Different responses of rat cerebellar Purkinje cells and Golgi cells evoked by widespread convergent sensory inputs
    Tahl Holtzman
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    J Physiol 574:491-507. 2006
    ..On this basis, Golgi cells may act as a context-specific gate on transmission through the mossy fibre-granule cell pathway...
  65. ncbi Effects of maternal oral morphine consumption on neural tube development in Wistar rats
    Shiva Nasiraei-Moghadam
    Department of Biology, Azad University, North Branch, Tehran, Iran
    Brain Res Dev Brain Res 159:12-7. 2005
    ..system, the present study focused on the effects of maternal morphine consumption on neural tube development in Wistar rats. Female Wistar rats (250-300 g) were crossed with male rats and coupling time was recorded (embryonic day 0-E0)...
  66. ncbi Endogenous VEGF-A is responsible for mitogenic effects of MCP-1 on vascular smooth muscle cells
    Astrid Parenti
    Laboratory of Vascular Pharmacology, Department of Preclinical and Clinical Pharmacology, University of Florence, 50139 Florence, Italy
    Am J Physiol Heart Circ Physiol 286:H1978-84. 2004
    ..1 pg/ml. These findings demonstrate that low concentrations of rat MCP-1 can directly promote rat VSMC proliferation and migration through the autocrine production of VEGF-A...
  67. ncbi Effect of palatable hyperlipidic diet on lipid metabolism of sedentary and exercised rats
    Debora Estadella
    Department of Physiology, Universidade Federal de Sao Paulo EPM, Biomedical Science Building, Rua Botucatu 862, Vila Clementino, 04023 060 São Paulo, SP, Brazil
    Nutrition 20:218-24. 2004
    ....
  68. ncbi Behavioural and cardiovascular responses during latent inhibition of conditioned fear: measurement by telemetry and conditioned freezing
    Wei Ning Zhang
    Behavioral Neurobiology Laboratory, The Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Switzerland
    Behav Brain Res 154:199-209. 2004
    ..g. NPE condition) activate both sympathetic and parasympathetic systems, thus eliminating any CS-induced increase in heart rate in the NPE rats...
  69. ncbi Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
    Yunzeng Zou
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Nat Cell Biol 6:499-506. 2004
    ..All of these events are inhibited by the AT1 receptor blocker candesartan. Thus, mechanical stress activates AT1 receptor independently of angiotensin II, and this activation can be inhibited by an inverse agonist of the AT1 receptor...
  70. ncbi A reliable method for the preferential activation of C- or A-fibre heat nociceptors
    Simon McMullan
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Neurosci Methods 138:133-9. 2004
    ..In contrast thresholds of responses to fast rates of skin heating were unchanged, indicating that nociceptors activated by this stimulus were capsaicin-insensitive A-fibre heat nociceptors...
  71. ncbi N-acetylcysteine prevents nitrosative stress-associated depression of blood pressure and heart rate in streptozotocin diabetic rats
    Prabhakara Reddy Nagareddy
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
    J Cardiovasc Pharmacol 47:513-20. 2006
    ..The results suggest that nitrosative stress depress MABP and HR following diabetes. Further studies are required to elucidate the mechanisms involved in nitrosative stress mediated depression of blood pressure and heart rate...
  72. ncbi Methimazole-induced hypothyroidism in rats ameliorates oxidative injury in experimental colitis
    C A Işman
    Department of Physiology, Marmara University, School of Medicine, 34716 Haydarpaşa, Istanbul, Turkey
    J Endocrinol 177:471-6. 2003
    ..In conclusion, methimazole reduces colonic oxidative injury probably due to hypometabolism, which is associated with a decrease in the production of reactive oxygen intermediates and an increase in the response of antioxidant systems...
  73. ncbi Effects of early-life stress on behavior and neurosteroid levels in the rat hypothalamus and entorhinal cortex
    Avi Avital
    Department of Psychology and The Brain and Behavior Research Center, University of Haifa, Mount Carmel, 31905 Haifa, Israel
    Brain Res Bull 68:419-24. 2006
    ..These effects may be of relevance to our understanding of early life stress-related disorders such as PTSD and major depression...
  74. ncbi In vivo and in vitro anti-androgenic effects of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture
    T E Stoker
    MD 72, Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States EPA, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 207:78-88. 2005
    ....
  75. ncbi Expression of serotonin1A and serotonin2A receptors in pyramidal and GABAergic neurons of the rat prefrontal cortex
    Noemí Santana
    Department of Neurochemistry, Institut d Investigacions Biomèdiques de Barcelona CSIC, IDIBAPS, 08036 Barcelona, Spain
    Cereb Cortex 14:1100-9. 2004
    ..These data help to clarify the role of 5-HT in prefrontal circuits and shed new light to the cellular elements involved in the action of atypical antipsychotics...
  76. ncbi Amino acid transporter SNAT5 localizes to glial cells in the rat brain
    Beatriz Cubelos
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Glia 49:230-44. 2005
    ....
  77. ncbi Antiandrogenic effects in male rats perinatally exposed to a mixture of di(2-ethylhexyl) phthalate and di(2-ethylhexyl) adipate
    Kirsten Jarfelt
    Danish Institute for Food and Veterinary Research, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Reprod Toxicol 19:505-15. 2005
    ..b>Wistar rats were gavaged with either vehicle, DEHP (300 or 750mg/kg bw/day) or DEHP (750mg/kg bw/day) in combination with ..
  78. ncbi Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats
    Narasimhanaidu Kamalakkannan
    Department of Biochemistry, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India
    Basic Clin Pharmacol Toxicol 98:97-103. 2006
    ..and antioxidant effect of rutin, a polyphenolic flavonoid in normal and streptozotocin-induced diabetic Wistar rats. Diabetes as induced in rats by an intraperitoneal injection of streptozotocin...
  79. ncbi Magnetic resonance imaging of changes elicited by status epilepticus in the rat brain: diffusion-weighted and T2-weighted images, regional blood volume maps, and direct correlation with tissue and cell damage
    P F Fabene
    Section of Anatomy and Histology, Department of Morphological and Biomedical Sciences, Faculty of Medicine, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    Neuroimage 18:375-89. 2003
    ..The findings provide an interpretation of the brain response to sustained seizures revealed in vivo by different strategies of MRI analysis...
  80. ncbi Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment
    Herbert Y Gaisano
    Department of Medicine and Physiology, University of Toronto, Ontario, Canada M5S 1A8
    Endocrinology 143:4218-26. 2002
    ..We propose that dysregulation of SNARE proteins is an important mechanism behind glucotoxicity-mediated impairment of the insulin response to glucose...
  81. ncbi Protective effects of ascorbic acid pretreatment in a rat model of intestinal ischemia-reperfusion injury: a histomorphometric study
    Oscar Haruo Higa
    Department of Pathology, Sao Paulo University Medical School, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 62:315-20. 2007
    ..Ascorbic acid has shown promise in attenuation of intestinal ischemia-reperfusion (I/R) injury. The aim of this study was to determine the protective effects of ascorbic acid on intestinal morphology during IR injury in rats...
  82. ncbi Angiogenic and astroglial responses to vascular endothelial growth factor administration in adult rat brain
    J M Krum
    Department of Anatomy and Cell Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    Neuroscience 110:589-604. 2002
    ..From these results we suggest that administered VEGF has heretofore unanticipated pleiotrophic effects in the adult CNS...
  83. ncbi Descending control of spinal nociception from the periaqueductal grey distinguishes between neurons with and without C-fibre inputs
    Alexander J Waters
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Pain 134:32-40. 2008
    ..g. fight or flight) or long term (e.g. chronic pain). Additionally, the pro-nociceptive effects observed in a subset of spinal neurons may be related to the descending facilitation that has been reported in animal models of chronic pain...
  84. pmc Interleukin-6 regulates pancreatic alpha-cell mass expansion
    Helga Ellingsgaard
    Division of Endocrinology and Diabetes and Center for Integrated Human Physiology, University Hospital of Zurich, 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 105:13163-8. 2008
    ....
  85. pmc Rat salivary gland ligation causes reversible secretory hypofunction
    G H Carpenter
    Salivary Research Unit, Floor 17, Guy s Tower, King s College London, London, UK
    Acta Physiol (Oxf) 189:241-9. 2007
    ..Secretion by salivary glands involves interactions between nerves, blood vessels and salivary cells. The present study investigated the effects of inflammation on rat submandibular gland function following acute ductal obstruction...
  86. ncbi Postprandial stimulation of muscle protein synthesis in old rats can be restored by a leucine-supplemented meal
    Dominique Dardevet
    Human Nutrition Research Centre of Clermont Ferrand and Institut National de la Recherche Agronomique, Unité de Nutrition et Métabolisme Protéique, 63122 Ceyrat, France
    J Nutr 132:95-100. 2002
    ..Whether chronic leucine meal supplementation may limit muscle protein wasting during aging remains to be verified...
  87. ncbi Two time periods of hippocampal mRNA synthesis are required for memory consolidation of fear-motivated learning
    Lionel Muller Igaz
    Instituto de Biologia Celular y Neurociencias, Facultad de Medicina, Universidad de Buenos Aires, 1121 Buenos Aires, Argentina
    J Neurosci 22:6781-9. 2002
    ....
  88. pmc IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat
    J A Ehses
    Division of Endocrinology, Diabetes, and Nutrition and Center for Integrated Human Physiology, University Hospital of Zurich, 8045 Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:13998-4003. 2009
    ..Rather than being directly cytotoxic, IL-1beta may drive tissue inflammation that impacts on both beta cell functional mass and insulin sensitivity in type 2 diabetes...
  89. ncbi Quantitative morphological study of microglial cells in the ischemic rat brain using principal component analysis
    Z Soltys
    Department of Neuroanatomy, Institute of Zoology, Jagiellonian University, 6 Ingardena St, 30 060 Cracow, Poland
    J Neurosci Methods 146:50-60. 2005
    ..The results presented show that the quantitative morphological analysis can be an effective tool in research on the reactive behaviour of microglia and, particularly, in the detection of small and early changes in the cells...
  90. ncbi Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats
    Joao M N Duarte
    Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurochem Int 48:144-50. 2006
    ....
  91. ncbi Aged garlic extract attenuates gentamicin induced renal damage and oxidative stress in rats
    Perla D Maldonado
    Department of Biology, Faculty of Chemistry, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 D F, Mexico, Mexico
    Life Sci 73:2543-56. 2003
    ..Four groups of male Wistar rats were studied: 1) Control (CT), injected subcutaneously (s.c.) and intraperitoneally (i.p...
  92. ncbi Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats
    John A O Ojewole
    Department of Pharmacology, Faculty of Health Sciences, University of KwaZulu Natal, Private Bag X54001, Durban, South Africa
    Phytother Res 20:764-72. 2006
    ....
  93. ncbi Sodium iodoacetate-induced experimental osteoarthritis and associated pain model in rats
    Kiyoshi Kobayashi
    Discovery Technology Laboratory, Mitsubishi Pharma Co, Yokohama, Japan
    J Vet Med Sci 65:1195-9. 2003
    Degenerative lesions were induced in the knee joint of Wistar rats by intraarticular injection of chondrocyte metabolism inhibitor mono-iodoacetate (MIA) at doses of 0, 0.3 or 3 mg/joint...
  94. ncbi Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells
    Carl Magnus Bäckesjö
    Department for Clinical Science, Intervention and Technology CLINTEC, Division of Orthopedics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
    J Bone Miner Res 21:993-1002. 2006
    ..However, adipocytes are also formed. We showed that activation of the nuclear protein deacetylase Sirt1 reduces adipocyte formation and promotes osteoblast differentiation...
  95. ncbi Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin
    Shuihua Zhang
    School of Pharmacy, East China University of Science and Technology, Mailbox 268, Shanghai 200237, China
    J Nutr Biochem 17:485-91. 2006
    ..In the present study, we investigated the effects of puerarin on liver fibrosis in Wistar rats induced by alcohol plus carbon tetrachloride administration...
  96. ncbi Presynaptic mechanism underlying cAMP-dependent synaptic potentiation
    Masahiro Kaneko
    Department of Neurophysiology, University of Tokyo Graduate School of Medicine, Tokyo 113 0033, Japan
    J Neurosci 24:5202-8. 2004
    ..We conclude that an increase in cAMP concentration in the nerve terminal facilitates transmitter release by increasing both release probability and number of releasable vesicles via activating the Epac pathway at the calyx of Held...
  97. ncbi Selenium and high dose vitamin E administration protects cisplatin-induced oxidative damage to renal, liver and lens tissues in rats
    Mustafa Naziroglu
    Department of Physiology, Veterinary Faculty, Firat University, TR 23119, Elazig, Turkey
    Toxicology 195:221-30. 2004
    ..Forty female Wistar rats were used. They were randomly divided into five groups...
  98. pmc Effects of antioxidant therapy on leukocyte myeloperoxidase and Cu/Zn-superoxide dismutase and plasma malondialdehyde levels in experimental colitis
    Ergul Belge Kurutas
    Department of Biochemistry, Medical Faculty, Sutcu Imam University, Turkey
    Mediators Inflamm 2005:390-4. 2005
    ..However, NAC and LCAR administration to the AA-treated rats significantly reduced the MDA levels compared to colitis group. In conclusion NAC and LCAR could be beneficial agents in restoring the circulating proinflammatory mediators...
  99. pmc Regulation of kainate receptors by protein kinase C and metabotropic glutamate receptors
    Kwangwook Cho
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 548:723-30. 2003
    ....
  100. ncbi The VIP2 receptor: molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide
    E M Lutz
    Department of Pharmacology, University of Edinburgh, UK
    FEBS Lett 334:3-8. 1993
    ..This suggests that RPR4 encodes a novel VIP receptor which we have designated the VIP2 receptor. In situ hybridisation showed that mRNA for this receptor was present mainly in the thalamus, hippocampus and in the suprachiasmatic nucleus...
  101. pmc Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin
    Lenka Ivings
    The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool, L69 3BX, U K
    Biochem J 363:599-608. 2002
    ..These data suggest the possibility that neurocalcin delta functions in the control of clathrin-coated vesicle traffic...

Research Grants64

  1. Food(cassava) cyanogen exposure and motor neuron degeneration
    DANIEL DESIRE TSHALA KATUMBAY; Fiscal Year: 2010
    ..and assess changes in selected indicators of protein misfolding in brain/spinal cord tissues of young Wistar rats kept on SAA-deficient diets and treated with linamarin, NaOCN (positive control) or equivalent amount of 5% ..
  2. Microdialysis Studies of Seizure-Induced Oxidative Stress
    Craig E Lunte; Fiscal Year: 2013
    ..Three experimental models of epilepsy will be used in Wistar rats. The first two models use 3-mercaptopropionic acid (3-MPA) to chemically induce seizures in a controlled manner...
  3. Adolescent Alcohol,Dysregulated Stress System, and PTSD Vulnerability
    GERHARD H SCHULTEIS; Fiscal Year: 2013
    ..In Specific Aim 1, young adult male Wistar rats will be exposed to one of several conditions of social defeat stress (Nondefeat Control, 3x, 6x, or 9x defeat ..
  4. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2013
    ..We will employ a model of chronic epilepsy that develops in male Wistar rats following pilocarpine - induced status epilepticus (SE)...
  5. Neurobiological basis of Depression as a Comorbidity in Epilepsy
    Andrey M Mazarati; Fiscal Year: 2010
    ..To induce TLE, two weeks-old Wistar rats will be subjected to LiCl and pilocarpine status epilepticus (SE)...
  6. Interaction of BPA and soy isoflavones on sociosexual behavior
    Heather B Patisaul; Fiscal Year: 2013
    ..Preliminary data from this laboratory reveal that many of these adverse behavioral effects do not manifest in Wistar rats maintained on a soy-rich diet, suggesting that soy isoflavones, such as genistein (GEN) have potentially ..
  7. Role of Endoplasmic Reticulum Stress in Obesity-Related Endothelial Dysfunction
    CHRISTOPHER GENTILE; Fiscal Year: 2013
    ..Aim 2 will examine if a high saturated fat diet induces ER stress in the vasculature of male Wistar rats, and if so, whether this ER stress mediates endothelial dysfunction that results from such a diet...
  8. The role of GLT1 in the modulation of alcohol-drinking behavior in P rats.
    Youssef Sari; Fiscal Year: 2013
    ..We will also investigate the effects of GLT1 activation in EtOH-drinking behavior in Wistar rats as comparison control groups...
  9. CRP, Diabetes, Atherothrombosis
    Ishwarlal Jialal; Fiscal Year: 2010
    ..the role of Fc-gamma receptors in the biological effects of CRP on endothelial cells, macrophages and in Wistar rats. Furthermore, we have elucidated the mechanism of CRPinduced monocyte adhesion under shear stress, and finally ..
  10. CNS SITES FOR THE REWARDING ACTIONS OF ALCOHOL
    William J McBride; Fiscal Year: 2013
    ..within the limbic system, selected experiments will be conducted with alcohol-preferring (P) rats and stock Wistar rats. The results of this project will provide important information on (a) CNS sites and receptors mediating the ..
  11. Electrophysiological ensembles organization during alcohol cue-induced intake and
    DAVID NATHANIEL LINSENBARDT; Fiscal Year: 2013
    ..P rats) and in a rat population with average genetic susceptibility to excessive alcohol consumption (Wistar rats)...
  12. Mechanisms of Metabolic Dysfunction in Type 2 Diabetes
    Robert W Wiseman; Fiscal Year: 2013
    ..Data will be obtained from male Wistar rats (normoglycemic) and the Goto Kakizaki rat model of T2D (hyperglycemic) to identify functional differences ..
  13. Suppression of glioma invasion by a bicistronic constuct
    JASTI RAO; Fiscal Year: 2007
    ..6) with that of the bicistronic gene construct (Ad-uPAR-p 16) given as intracerebral injections in Fischer or Wistar rats. 3) Assess the effect of the bicistronic Ad-uPAR-pl6 construct on the expression of integrins (particularly ..
  14. The role of the circadian clock in encoding seasonal variations in day length
    JULIE SUZANNE PENDERGAST; Fiscal Year: 2010
    ..be determined whether photoperiod encoding in the SCN differs between photoperiodic F344 and nonphotoperiodic Wistar rats. Seasonal variations in photoperiod may also affect neurological processes in humans...
  15. Quantitative MRI-based Assessment of Aerosol Deposition in the Lung
    Chantal Darquenne; Fiscal Year: 2009
    ..Six weeks prior to aerosol exposure, emphysema will be induced in Wistar rats by intratracheal instillation of pancreatic elastase...
  16. Involvement of Aldehydes in Alcohol Addiction
    William McBride; Fiscal Year: 2009
    ..addition, this aim will determine the dose-response effects for the ICSA of ACD and SAL into the VTA and NAC of Wistar rats and whether these effects are different from the dose-response effects obtained with P rats...
  17. RENIN-ANGIOTENSIN AND GROWTH IN URETERAL OBSTRUCTION
    ROBERT CHEVALIER; Fiscal Year: 1991
    ..the effects of individual tubular obstruction on the associated juxtaglomerular apparatus, tubules of Munich-Wistar rats will be blocked by micropuncture...
  18. Brain serotonin and angiotensin II systems in migraine
    JOSE TERRON; Fiscal Year: 2007
    ..of 5-HT receptors in the cerebral vasculature and the HPA axis, will be determined in control and 5-HT-depleted Wistar rats. It will be determined whether chronic treatment with a migraine prophylactic 5-HT antagonist restore 5-HT ..
  19. FAT CELL PROLIFERATION IN OBESITY--MODULATING FACTORS
    Roy Martin; Fiscal Year: 1999
    ..be examined: l) genetic-induced obesity: Zucker fat/fat rats; 2) spontaneous obesity that accompanies old age: Wistar rats; 3) diet-induced obesity: high fat diet (HFD)-fed Wistar rats; 4) seasonal (photoperiod)-induced obesity: ..
  20. ROLE OF PROTEIN PHOSPHATASES IN INSULIN SECRETION
    Anjaneyulu Kowluru; Fiscal Year: 2004
    ..ACC-PPase is abolished in islet derived from the GK rat, a model for NIDDM, compared to islets from the control Wistar rats. Using isolated rat islets and pure beta (HIT-T15 and INS-1) cells, the investigators propose to study the ..
  21. 1H MRS to diagnose bone weakening from aging /inactivity
    Dieter Schellinger; Fiscal Year: 2001
    ..In group B, twelve female Wistar rats will be used. There will be three animals in each age category (3, 12, 21, and 30 months)...
  22. Hypoxia and free radicals in alcoholic pancreatitis
    Gavin Arteel; Fiscal Year: 2005
    ..Our first goal is to characterize this new model. Wistar rats will receive alcohol internally using our modified protocol for up to 6 months...
  23. Involvement of Aldehydes in Alcohol Addiction
    William McBride; Fiscal Year: 2002
    ..The present application will extend these findings using male P and Wistar rats. Specific aim 1 will examine the dose-response effects of ACD within the anterior VTA, as well as in regions ..
  24. Prenatal xenoestrogen exposure and mammary cancer
    ANA SOTO; Fiscal Year: 2006
    ..A pilot study performed using Wistar rats showed that this model could be modified to assess the effect of fetal exposure to environmentally relevant ..
  25. GENETIC COMPONENT OF AUTONOMIC DYSREFLEXIA
    Robert Blair; Fiscal Year: 2000
    ..Previously experiments from this laboratory indicated that Wistar rats developed autonomic dysreflexia in response to colorectal distention following an upper thoracic spinal cord ..
  26. Adrenal decommissioning and hypertension
    Elise Gomez Sanchez; Fiscal Year: 2007
    ..Aim 1: ZG decomissioning in Wistar rats that have been subjected to chronic sodium depletion, then acutely repleted with sodium will be studied...
  27. Alpha- & Gamma-Synuclein Modulation of the NET After Antidepressant Treatment of
    Alexis Jeannotte; Fiscal Year: 2007
    ..We will treat WKY and Wistar rats with DMI or saline and examine NET interactions with a-Syn and ?-Syn, through co- immunoprecipitation assays...
  28. N-Acetylcysteine as a Biomonitoring Agent of Methylmercury Exposure
    DAVID AREMU; Fiscal Year: 2007
    ..In vivo techniques using Wistar Rats exposed to [14C]MeHg prior to NAC challenge, shall be employed for the biomonitoring of MeHg in urine samples...
  29. IN VIVO INDUCTION AND REPAIR OF GENOMIC INSTABILITY
    ANTONE BROOKS; Fiscal Year: 2000
    ..b>Wistar rats will be exposed to graded doses of both low LET X-rays and HZE particles (10000 MeV/Amu)...
  30. RENAL TUBULAR PC02 AND ACID-BASE EQUILIBRIUM
    F Gennari; Fiscal Year: 1990
    ..The assumptions used to develop the models will be tested by specific experimental maneuvers in Munich-Wistar rats designed to produce measurable changes in renal cortical PCO2...
  31. ASSESSMENT OF INTRAPORTAL HEPATOCYTE TRANSPLANTATION
    GEOFFREY BUDD; Fiscal Year: 1980
    ..such a possibility, it is proposed that hepatocytes will be isolated from heterozygous Gunn rats and Wistar rats; they will be radioactively labeled in vivo or in vitro and transplanted via the portal vein into the liver of ..
  32. Building better animal models of prostate cancer
    Milton Datta; Fiscal Year: 2004
    ..using expression microarray technology and utilize this pattern as a phenotype in future evaluation of Lobund-Wistar rats. These studies are essential in the development of new animal models of prostate cancer.
  33. EVALUATION OF CHROMOPHORE MODIFIED ACTINOMYCIN D
    SISIR SENGUPTA; Fiscal Year: 1993
    ..distribution of the enantiomers and biological adducts and conjugates in the bile, urine and tissues of Wistar rats in a time dependent study...
  34. FUNCTIONAL & HORMONAL ADAPTATIONS OF REMNANT NEPHRONS
    JUAN PELAYO; Fiscal Year: 1993
    ..To evaluate this hypothesis studies will be conducted in Munich-Wistar rats to document the magnitude and sequence of the functional and structural compensatory adaptations of the ..
  35. MECHANISMS OF ANOREXIA WITH TUMOR GROWTH
    DONNA MCCARTHY BECKETT; Fiscal Year: 1993
    ..The studies will be conducted using male Wistar rats in whom the metabolic, immunological and nutritional responses to infection or tumor growth will be monitored...
  36. ISCHEMIA, DIABETES, AND THE MICROCIRCULATION
    Umberto Degirolami; Fiscal Year: 1980
    ..The model of diabetes will be the spontaneously diabetic Wistar rats. The overall approach will be to correlate, wherever possible: (a) the study of living vessels under the ..
  37. CHEMICAL TOXICITY AND VITAMIN E REGULATION
    Donald Reed; Fiscal Year: 2001
    ..In Specific Aim 3 we will use a strain of Wistar rats which are unable to produce vitamin C to investigate the turnover of vitamin E and oxidation products formed ..
  38. CHARACTERIZATION OF SPONTANEOUSLY DIABETIC WISTAR RATS
    GLORIA TANNENBAUM; Fiscal Year: 1980
    ..4. To modify the time of onset of the spontaneous diabetic state by treatment with immunosuppressive drugs (cyclophosphamide) and with sub-diabetogenic doses of streptozotocin. ..
  39. Impulsivity, Dopamine and the Behavioral Economics of Gambling
    GREGORY MADDEN; Fiscal Year: 2009
    ..Experiment 2 will investigate the role of pramipexole and PD 128 907 (two selective D3 agonists) on Wistar rats'degree of delay discounting and preferences for gambling...
  40. MRI Measure of Blood Brain Barrier Permeability
    James Ewing; Fiscal Year: 2006
    ..We will demonstrate these measures in 9L tumors in Fischer 344 rats, and in reperfused ischemic infarction in Wistar rats.
  41. SODIUM & NEUROPEPTIDES IN STRESS INDUCED HYPERTENSION
    JULIANNA SZILAGYI; Fiscal Year: 1991
    ..Fully instrumented conscious Wistar rats will be used to obtain data concerning the hemodynamic status (blood pressure, cardiac output, total peripheral ..
  42. Control and Quantitation of Pulmonary Contusion
    Joel Stitzel; Fiscal Year: 2005
    ..Methods: The study population is Male Wistar rats, for which a pulmonary contusion injury model exists but is not well developed...
  43. Effect of Hepatotoxins & Adomet on Liver Gene Expression
    Warren Kruger; Fiscal Year: 2003
    ..Our experimental approach will use Wistar rats that are assigned to one of six groups: untreated AdoMet treated, alcohol treated, alcohol+AdoMet treated, CCI_ ..
  44. PATHOGENESIS OF HYPERTENSIVE CARDIOVASCULAR DISEASE
    JOSEPH WIENER; Fiscal Year: 1992
    ..between noradrenergic, angiotensin II and muscarinic receptors in isolated cerebral cortical microvessels from Wistar rats (WR) with short term two-kidney, one clip Goldblatt hypertension: 2) to assess in cerebral cortical ..
  45. ANTIDEPRESSANT THERAPY AND HYPOGLYCEMIA
    Dianne Lattemann; Fiscal Year: 2006
    ..To test these hypotheses we will administer sertraline, acutely or chronically, to non-diabetic Wistar rats and will measure the neuroendocrine counterregulatory response to a bout of hypoglycemia...
  46. METABOLIC OSCILLATIONS AND INSULIN SECRETION
    Keith Tornheim; Fiscal Year: 2000
    ..seen in islets from the GK rat, a non-obese model of NIDDM, and in islets from high fat/sucrose-fed (HFHS) Wistar rats. The specific aims are to determine (i) how interference with oscillatory glycolysis affects the rise in the ..
  47. Stem Cell Integration in the Injured Hippocampus
    Bjorn Scheffler; Fiscal Year: 2005
    ..cell loss affecting and impairing the hippocampal formation: the flathead mutant and sublethally irradiated Wistar rats. The rationale for choosing the animal models was that, although etiologically different, they both have in ..
  48. NEURAL PLASTICITY/VASCULAR REMODELING AFTER MINISTROKE
    Ling Wei; Fiscal Year: 2002
    A new directly observable model for targeted strokes in adult Wistar rats will be used to test recovery of function in somatosensory cortex through restored microcirculation and neural plasticity...
  49. PATHOGENESIS OF ATHEROSCLEROSIS IN RATS
    J Carter; Fiscal Year: 1980
    ..The use of these two animal types along with normal Wistar rats (normotensive and normolipidemic) should permit us to compare and evaluate the roles played by high blood ..
  50. Gene expression associated with the CNS reinforcing act*
    ZACHARY RODD HENRICKS; Fiscal Year: 2003
    ..The results of the proposed project will provide valuable information on neuronal systems and receptors within the extended amygdala involved in mediating the rewarding properties of alcohol. ..
  51. A THERAPEUTIC MODEL FOR CEREBRAL ISCHEMIA
    TERESITA BRIONES; Fiscal Year: 2003
    ..From a nursing perspective, results from this study are important clinically because the needs of most survivors of brain injury often times are for continuous nursing, while use of medical services may be intermittent. ..
  52. BAEP SCREENING OF NEONATES
    MICHAEL CHURCH; Fiscal Year: 2001
    ..This proposal will address these issues as well. Potentially confounding variables will be gathered and their influence assessed and statistically controlled. Appropriate clinical interventions for mother and infant will be made. ..
  53. GENE EXPRESSION-ENVIRONMENT LINK IN CEREBRAL ISCHEMIA
    TERESITA BRIONES; Fiscal Year: 2006
    ..Adult male and female Wistar rats will receive either ischemia or sham (control) surgery...
  54. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2006
    ..abstract_text> ..
  55. Alcoholism risk and protective factors in Trinidad
    Cindy Ehlers; Fiscal Year: 2006
    ..Study findings can be compared to similar studies being conducted in the US. We believe these studies will allow for the identification of risk and protective factors for alcoholism in these islands. [unreadable] [unreadable]..
  56. RISK FACTORS FOR ALCOHOLISM IN NATIVE AMERICANS
    Cindy Ehlers; Fiscal Year: 2006
    ..The identification of such variables may potentially be useful in the development of specific prevention and treatment programs for this population as well as other Native American tribes. ..
  57. Role of the CRF2 Receptor in Ingestive Behavior
    Eric Zorrilla; Fiscal Year: 2005
    ..The proposed studies will address these questions as well to understand better the role of the CRF2 receptor in feeding behavior. ..
  58. Urocortins Brain CRF2 Receptors and Energy Balance
    Eric P Zorrilla; Fiscal Year: 2010
    ....
  59. Galanin Control of Food Intake: Molecular, Neuroanatomical and Behavioral Bases
    Eric P Zorrilla; Fiscal Year: 2010
    ....
  60. Programmed adiposity: genetic in utero and postnatal determinants
    Eric Zorrilla; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  61. The dark side of preferred food addiction: role of CRF systems
    Pietro Cottone; Fiscal Year: 2008
    ..Relevance: The project seeks to define the role and potential therapeutic relevance of stress-related CRF systems on food addiction. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  62. ADOLESCENT MARIJUANA USE IN NATIVE AMERICANS
    Cindy Ehlers; Fiscal Year: 2008
    ..abstract_text> ..
  63. Neurobehavioral Consequences of Adolescent Alcohol
    Cindy Ehlers; Fiscal Year: 2008
    ..AIM 3: To investigate the neurochemical substrates underlying the lasting neurobehavioral consequences of adolescent ethanol exposure, with a focus on NMDA systems ..
  64. Nephrology Training Grant
    Scott Thomson; Fiscal Year: 2008
    ..An interactive research environment and shared seminar programs between UCSD, Salk Institute, and numerous other research institutes in La Jolla further enhances the training program. ..