long evans rats

Summary

Summary: An outbred strain of rats developed in 1915 by crossing several Wistar Institute white females with a wild gray male. Inbred strains have been derived from this original outbred strain, including Long-Evans cinnamon rats (RATS, INBRED LEC) and Otsuka-Long-Evans-Tokushima Fatty rats (RATS, INBRED OLETF), which are models for Wilson's disease and non-insulin dependent diabetes mellitus, respectively.

Top Publications

  1. ncbi Speed and accuracy of olfactory discrimination in the rat
    Naoshige Uchida
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 6:1224-9. 2003
  2. ncbi Hippocampal plasticity across multiple days of exposure to novel environments
    Loren M Frank
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurosci 24:7681-9. 2004
  3. ncbi Hippocampal neurons encode information about different types of memory episodes occurring in the same location
    E R Wood
    Laboratory of Cognitive Neurobiology, Boston University, Massachusetts 02215, USA
    Neuron 27:623-33. 2000
  4. ncbi Distinct ensemble codes in hippocampal areas CA3 and CA1
    Stefan Leutgeb
    Centre for the Biology of Memory, Medical Technical Research Centre, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 305:1295-8. 2004
  5. ncbi A controlled high-fat diet induces an obese syndrome in rats
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati School of Medicine, OH 45267, USA
    J Nutr 133:1081-7. 2003
  6. ncbi Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning
    Henry H Yin
    Department of Psychology, and Brain Research Institute, University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095 1563, USA
    Eur J Neurosci 19:181-9. 2004
  7. ncbi Temporal interaction between single spikes and complex spike bursts in hippocampal pyramidal cells
    K D Harris
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
    Neuron 32:141-9. 2001
  8. pmc Network dynamics underlying the formation of sparse, informative representations in the hippocampus
    Mattias P Karlsson
    W M Keck Center for Integrative Neuroscience and Department of Physiology, University of California, San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 28:14271-81. 2008
  9. ncbi Cellular actions of urethane on rat visual cortical neurons in vitro
    Michael P Sceniak
    Department of Anesthesia, Stanford University School of Medicine, Room S288, Stanford, California 94305 5117, USA
    J Neurophysiol 95:3865-74. 2006
  10. ncbi Variations in maternal care in the rat as a mediating influence for the effects of environment on development
    Frances A Champagne
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, 6875 LaSalle Boulevard, Montreal, Quebec, Canada H4H 1R3
    Physiol Behav 79:359-71. 2003

Detail Information

Publications293 found, 100 shown here

  1. ncbi Speed and accuracy of olfactory discrimination in the rat
    Naoshige Uchida
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 6:1224-9. 2003
    ....
  2. ncbi Hippocampal plasticity across multiple days of exposure to novel environments
    Loren M Frank
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurosci 24:7681-9. 2004
    ..These results show that the hippocampus can form new spatial representations quickly but that stable hippocampal representations are not sufficient for a place to be treated as familiar...
  3. ncbi Hippocampal neurons encode information about different types of memory episodes occurring in the same location
    E R Wood
    Laboratory of Cognitive Neurobiology, Boston University, Massachusetts 02215, USA
    Neuron 27:623-33. 2000
    ..This pattern of results suggests that hippocampal representations encode some of the information necessary for representing specific memory episodes...
  4. ncbi Distinct ensemble codes in hippocampal areas CA3 and CA1
    Stefan Leutgeb
    Centre for the Biology of Memory, Medical Technical Research Centre, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 305:1295-8. 2004
    ..In CA1, the activated populations overlapped, and the overlap increased in similar enclosures. After exposure to a novel room, ensemble activity developed slower in CA3 than CA1, suggesting that the representations emerged independently...
  5. ncbi A controlled high-fat diet induces an obese syndrome in rats
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati School of Medicine, OH 45267, USA
    J Nutr 133:1081-7. 2003
    ..This model of diet-induced obesity will be a useful tool for studying the mechanisms by which dietary fat influences the regulation of energy balance...
  6. ncbi Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning
    Henry H Yin
    Department of Psychology, and Brain Research Institute, University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095 1563, USA
    Eur J Neurosci 19:181-9. 2004
    ..Furthermore, it suggests that, when the habit system is disrupted, control over instrumental performance reverts to the system controlling the performance of goal-directed instrumental actions...
  7. ncbi Temporal interaction between single spikes and complex spike bursts in hippocampal pyramidal cells
    K D Harris
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
    Neuron 32:141-9. 2001
    ....
  8. pmc Network dynamics underlying the formation of sparse, informative representations in the hippocampus
    Mattias P Karlsson
    W M Keck Center for Integrative Neuroscience and Department of Physiology, University of California, San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 28:14271-81. 2008
    ..This process is not evident in CA3, indicating that a region-specific and long timescale process operates in CA1 to create a sparse, spatially informative population of neurons...
  9. ncbi Cellular actions of urethane on rat visual cortical neurons in vitro
    Michael P Sceniak
    Department of Anesthesia, Stanford University School of Medicine, Room S288, Stanford, California 94305 5117, USA
    J Neurophysiol 95:3865-74. 2006
    ..These results are consistent with observations seen in vivo during urethane anesthesia where urethane produced minimal disruption of signal transmission in the neocortex...
  10. ncbi Variations in maternal care in the rat as a mediating influence for the effects of environment on development
    Frances A Champagne
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, 6875 LaSalle Boulevard, Montreal, Quebec, Canada H4H 1R3
    Physiol Behav 79:359-71. 2003
    ..Overall, these findings indicate considerable, normal variations in licking/grooming in the rat that are a stable, individual characteristic of rat dams...
  11. ncbi Cholinergic basal forebrain neurons burst with theta during waking and paradoxical sleep
    Maan Gee Lee
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 25:4365-9. 2005
    ..Through their maximal firing and rhythmic theta discharge during active waking and paradoxical sleep, the cholinergic neurons can thus modulate the cortex to promote activation along with plasticity during these two states...
  12. ncbi Trajectory encoding in the hippocampus and entorhinal cortex
    L M Frank
    Center for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 27:169-78. 2000
    ....
  13. ncbi Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment
    R L Huot
    Stress Neurobiology Laboratory, Department of Psychiatry and Behavioral Sciences, Emory University, Suite 4000, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 158:366-73. 2001
    ..CONCLUSIONS: These observations suggest that this maternal separation paradigm is a good model to study the effects of early adverse experience on the development of alcohol preference and anxiety...
  14. ncbi Role of experience and oscillations in transforming a rate code into a temporal code
    M R Mehta
    Center for Learning and Memory, Department of Brain and Cognitive Sciences, RIKEN MIT Neuroscience Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 417:741-6. 2002
    ..The resulting spike timing satisfies the temporal order constraints of hebbian learning. Thus, oscillations and receptive field asymmetry may have a critical role in temporal sequence learning...
  15. ncbi Hypothalamic mTOR signaling regulates food intake
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Science 312:927-30. 2006
    ..Thus, mTOR is a cellular fuel sensor whose hypothalamic activity is directly tied to the regulation of energy intake...
  16. ncbi Is spontaneous high-voltage rhythmic spike discharge in Long Evans rats an absence-like seizure activity?
    Fu Zen Shaw
    Institute of Neuroscience, Tzu Chi University, Hualien 970, Taiwan
    J Neurophysiol 91:63-77. 2004
    ..characterized by a barrage of negative spikes oscillating at 5-12 Hz was observed in chronically implanted Long Evans rats. Spontaneous HVRS discharges were exhibited in 90% of 40 Long Evans rats and occurred during sudden arrest of ..
  17. ncbi Coordinated memory replay in the visual cortex and hippocampus during sleep
    Daoyun Ji
    The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 10:100-7. 2007
    ..These results imply simultaneous reactivation of coherent memory traces in the cortex and hippocampus during sleep that may contribute to or reflect the result of the memory consolidation process...
  18. ncbi Effects of serotonin on the intrinsic membrane properties of layer II medial entorhinal cortex neurons
    Li Ma
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Hippocampus 17:114-29. 2007
    ..Serotonin is thus likely to influence, in a composite fashion, the information processing of Layer II neurons in the mEC and thus, the passage of neocortical information via the perforant pathway to the hippocampus...
  19. ncbi The neural correlates and role of D1 dopamine receptors in renewal of extinguished alcohol-seeking
    A S Hamlin
    School of Psychology, The University of New South Wales, Sydney, NSW, 2052, Australia
    Neuroscience 146:525-36. 2007
    ..Neuroscience 143:25-38] permits identification of similarities and differences in the correlates of renewal of extinguished drug- and natural-reward seeking...
  20. ncbi Spatial representation in the entorhinal cortex
    Marianne Fyhn
    Centre for the Biology of Memory, Medical Technical Research Centre, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 305:1258-64. 2004
    ....
  21. pmc Optimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction
    Sami Ellouze
    Institut de la Vision, Universite Pierre et Marie Curie PARIS6, Unité mixte de recherche S 592, 17 rue Moreau, Paris F 75012, France
    Am J Hum Genet 83:373-87. 2008
    ..Hence, these data provide the proof-of-principle that optimized allotopic expression can be an effective treatment for LHON, and they open the way to clinical studies on other devastating mitochondrial disorders...
  22. ncbi Contribution of TNF-alpha to leukocyte adhesion, vascular leakage, and apoptotic cell death in endotoxin-induced uveitis in vivo
    Kan Koizumi
    Department of Vitreoretinal Surgery, Center for Ophthalmology, and Center for Molecular Medicine, University of Cologne, Cologne, Germany
    Invest Ophthalmol Vis Sci 44:2184-91. 2003
    ..To investigate the effect of TNF-alpha on leukocyte adhesion, vascular leakage, and apoptotic cell death in endotoxin-induced uveitis (EIU) in the rat...
  23. ncbi Context fear learning in the absence of the hippocampus
    Brian J Wiltgen
    Psychology and the Brain Research Institute, University of California, Los Angeles, California 90095, USA
    J Neurosci 26:5484-91. 2006
    ..These results demonstrate that alternative systems can acquire context fear but do so less efficiently than the hippocampus...
  24. ncbi Differential contributions of dorsal hippocampal subregions to memory acquisition and retrieval in contextual fear-conditioning
    Inah Lee
    Department of Neurobiology and Anatomy, University of Texas Houston Medical School, Houston, Texas, USA
    Hippocampus 14:301-10. 2004
    ..e., CA1 and dentate gyrus) were critically involved. The results indicate time-dependent differential contributions of the hippocampal subregions to memory acquisition and retrieval in contextual fear-conditioning...
  25. ncbi VEGF164 is proinflammatory in the diabetic retina
    Susumu Ishida
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 44:2155-62. 2003
    ....
  26. pmc Critical role of the hippocampus in memory for sequences of events
    Norbert J Fortin
    Laboratory of Cognitive Neurobiology, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
    Nat Neurosci 5:458-62. 2002
    ..These findings support the hypothesis that hippocampal networks mediate associations between sequential events that constitute elements of an episodic memory...
  27. ncbi Cell-intrinsic regulation of axonal morphogenesis by the Cdh1-APC target SnoN
    Judith Stegmuller
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Neuron 50:389-400. 2006
    ..These findings define Cdh1-APC and SnoN as components of a cell-intrinsic pathway that orchestrates axonal morphogenesis in a transcription-dependent manner in the mammalian brain...
  28. ncbi Effects of atomoxetine and methylphenidate on attention and impulsivity in the 5-choice serial reaction time test
    Rachel Navarra
    Discovery Neuroscience, Wyeth Research, 500 Arcola Road, PA 19426 USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:34-41. 2008
    ..The present experiments investigated the effects of acute methylphenidate and atomoxetine in male long Evans rats in the 5-choice serial reaction time (5CSRT) test that is hypothesized to serve as a model of vigilance and ..
  29. ncbi Microstructure of a spatial map in the entorhinal cortex
    Torkel Hafting
    Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Nature 436:801-6. 2005
    ..The map is anchored to external landmarks, but persists in their absence, suggesting that grid cells may be part of a generalized, path-integration-based map of the spatial environment...
  30. ncbi Graded persistent activity in entorhinal cortex neurons
    Alexei V Egorov
    Department of Neurology and Neurosurgery, Montreal Neurological Institute and McGill University, Montreal, Quebec H3A 2B4, Canada
    Nature 420:173-8. 2002
    ..Such an intrinsic neuronal ability to generate graded persistent activity constitutes an elementary mechanism for working memory...
  31. ncbi Cue control and head direction cells
    J P Goodridge
    Department of Psychology, Dartmouth College, Hanover, New Hampshire 03755, USA
    Behav Neurosci 112:749-61. 1998
    ..These latter results indicate that HD cells rely on a rapid learning mechanism to develop associations with landmark cues...
  32. ncbi Orbitofrontal lesions in rats impair reversal but not acquisition of go, no-go odor discriminations
    Geoffrey Schoenbaum
    Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles Street, 25 Ames Hall, Baltimore, MD 21218, USA
    Neuroreport 13:885-90. 2002
    ..These findings suggest that orbitofrontal cortex is not necessary for inhibiting responses unless responses must be altered to reflect changing relationships between cues and outcomes...
  33. ncbi Development of cholinergic modulation and graded persistent activity in layer v of medial entorhinal cortex
    Antonio Reboreda
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Neurophysiol 97:3937-47. 2007
    ..All these data suggest that the implementation of mnemonic properties in mEC principal neurons matches the ontogenic development of afferent cholinergic circuits and their signaling components...
  34. pmc Persistent firing supported by an intrinsic cellular mechanism in a component of the head direction system
    Motoharu Yoshida
    Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 29:4945-52. 2009
    ..These results suggest that persistent firing of head direction cells in the postsubiculum could be supported by an intrinsic mechanism...
  35. ncbi Cholinergic deafferentation of the entorhinal cortex in rats impairs encoding of novel but not familiar stimuli in a delayed nonmatch-to-sample task
    Jill McGaughy
    Department of Psychology Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 25:10273-81. 2005
    ..This indicates an important role for cholinergic innervation of the entorhinal cortex in working memory for novel stimuli...
  36. pmc Internally generated cell assembly sequences in the rat hippocampus
    Eva Pastalkova
    Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
    Science 321:1322-7. 2008
    ..Such sequences were not formed in control (nonmemory) tasks. We hypothesize that neuronal representations, evolved for encoding distance in spatial navigation, also support episodic recall and the planning of action sequences...
  37. ncbi Scale-invariant memory representations emerge from moiré interference between grid fields that produce theta oscillations: a computational model
    Hugh T Blair
    University of California, Los Angeles Psychology Department, Los Angeles, California 90095, USA
    J Neurosci 27:3211-29. 2007
    ..We therefore propose that moiré interference between grid fields may constitute an important principle of neural computation underlying the construction of scale-invariant memory representations...
  38. pmc mGluR-dependent persistent firing in entorhinal cortex layer III neurons
    Motoharu Yoshida
    Center for Memory and Brain, Boston University, Boston, MA 02215, USA
    Eur J Neurosci 28:1116-26. 2008
    ....
  39. ncbi Storage of spatial information by the maintenance mechanism of LTP
    Eva Pastalkova
    Departments of Physiology, Pharmacology, and Neurology, Robert F Furchgott Center for Neural and Behavioral Science, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Science 313:1141-4. 2006
    ..Thus, the mechanism maintaining LTP sustains spatial memory...
  40. ncbi The role of the dorsomedial striatum in instrumental conditioning
    Henry H Yin
    Department of Psychology and Brain Research Institute, University of California, Los Angeles, Box 951563, Los Angeles, CA 90095 1563, USA
    Eur J Neurosci 22:513-23. 2005
    ..Taken together, these results suggest that the posterior region of the DMS is a crucial neural substrate for the acquisition and expression of action-outcome associations in instrumental conditioning...
  41. ncbi Discriminative whisking in the head-fixed rat: optoelectronic monitoring during tactile detection and discrimination tasks
    M A Harvey
    Biopsychology Program, Hunter College, CUNY, New York, NY 10021, USA
    Somatosens Mot Res 18:211-22. 2001
    ..We conclude that the functional contribution of the macrovibrissae will vary with the nature of the task and the conditions of testing...
  42. pmc Temporal frequency of subthreshold oscillations scales with entorhinal grid cell field spacing
    Lisa M Giocomo
    Center for Memory and Brain, Department of Psychology, Program in Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA
    Science 315:1719-22. 2007
    ....
  43. ncbi Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspring
    Frances A Champagne
    Douglas Hospital Research Center, Montreal, Quebec, Canada H4H 1R3
    Endocrinology 147:2909-15. 2006
    ....
  44. pmc The anxiogenic drug yohimbine reinstates palatable food seeking in a rat relapse model: a role of CRF1 receptors
    Udi E Ghitza
    Behavioral Neuroscience Branch, NIDA IRP NIH DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 31:2188-96. 2006
    ..These data suggest that CRF is involved in stress-induced relapse to palatable food seeking, and that CRF1 antagonists should be considered for the treatment of maladaptive eating habits...
  45. ncbi Kainate induces rapid redistribution of the actin cytoskeleton in ameboid microglia
    Randolph N Christensen
    Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci Res 84:170-81. 2006
    ..These findings suggest direct microglial excitation via glutamate receptor pathways. Thus, neurotransmitter release after brain or spinal cord injury might directly modulate the inflammatory response...
  46. ncbi The effects of chronic mild stress on male Sprague-Dawley and Long Evans rats: I. Biochemical and physiological analyses
    C Bielajew
    School of Psychology, University of Ottawa, 11 Marie Curie, Ottowa, ON, Canada K1N 6N5
    Behav Brain Res 136:583-92. 2002
    ..quadratic pattern of stressor-elicited fluctuations in this measure was similar in both Sprague-Dawley and Long Evans rats, with consistently elevated levels for the first hour following exposure to the acute stressor; near baseline ..
  47. ncbi Natural variations in maternal care are associated with estrogen receptor alpha expression and estrogen sensitivity in the medial preoptic area
    Frances A Champagne
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, 6875 LaSalle Boulevard, Montreal, Canada H4H 1R3
    Endocrinology 144:4720-4. 2003
    ..These findings suggest that natural variations in maternal care are associated with differences in ER alpha expression in the MPOA and that such differences are transmitted from the mother to her female offspring...
  48. ncbi Local generation of theta-frequency EEG activity in the parasubiculum
    Stephen D Glasgow
    Center for Studies in Behavioral Neurobiology, Dept of Psychology, Concordia University, 7141 Sherbrooke St W, Rm SP 244, Montreal, Quebec H4B 1R6, Canada
    J Neurophysiol 97:3868-79. 2007
    ....
  49. ncbi Coordinated interactions between hippocampal ripples and cortical spindles during slow-wave sleep
    A G Siapas
    Center for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 21:1123-8. 1998
    ..This coactivation of hippocampal and neocortical pathways may be important for the process of memory consolidation, during which memories are gradually translated from short-term hippocampal to longer-term neocortical stores...
  50. ncbi Distinct GABAergic targets of feedforward and feedback connections between lower and higher areas of rat visual cortex
    Yuri Gonchar
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 23:10904-12. 2003
    ..Unlike FF input, FB input in addition makes a disynaptic link via CR neurons, which may influence the excitability of distal pyramidal cell dendrites in layer 1...
  51. ncbi Memory of sequential experience in the hippocampus during slow wave sleep
    Albert K Lee
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 36:1183-94. 2002
    ..This rapid encoding of sequential experience is consistent with evidence that the hippocampus is crucial for spatial learning in rodents and the formation of long-term memories of events in time in humans...
  52. ncbi Replay of rule-learning related neural patterns in the prefrontal cortex during sleep
    Adrien Peyrache
    College de France, Centre National de la Recherche Scientifique, Paris, France
    Nat Neurosci 12:919-26. 2009
    ..Therefore, learning, or the resulting reliable reward, influenced which patterns were most strongly encoded and successively reactivated in the hippocampal/prefrontal network...
  53. ncbi An extraordinary degree of structural specificity is required in neural phospholipids for optimal brain function: n-6 docosapentaenoic acid substitution for docosahexaenoic acid leads to a loss in spatial task performance
    Sun Young Lim
    Division of Marine Environment and Bioscience, Korea Maritime University, Busan, Korea
    J Neurochem 95:848-57. 2005
    ..In conclusion, DPAn-6 could not replace DHA for brain function, indicating a highly specific structural requirement for DHA...
  54. pmc Social defeat stress produces prolonged alterations in acoustic startle and body weight gain in male Long Evans rats
    John V K Pulliam
    Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, United States
    J Psychiatr Res 44:106-11. 2010
    ..These data indicate that the severe stress of social defeat can produce physiologic and behavioral outcomes which may reflect aspects of traumatic psychosocial stress...
  55. ncbi Effect of oral intake of dibutyl phthalate on reproductive parameters of Long Evans rats and pre-pubertal development of their offspring
    Veronica Salazar
    Laboratory of Experimental Endocrinology, Department of Physiology, School of Medicine, Complutense University of Madrid, Avda Complutense s n, 28040 Madrid, Spain
    Toxicology 205:131-7. 2004
    ..Pups were weaned at 22 days of age and continued into three experimental groups according to diet. From day 22 onwards, vaginal opening, occurrence of first estrous, and pre-putial separation were recorded...
  56. ncbi Disposition of polychlorinated dibenzo-p-dioxins, dibenzofurans, and non-ortho polychlorinated biphenyls in pregnant long evans rats and the transfer to offspring
    C Y Chen
    Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7400, USA
    Toxicol Appl Pharmacol 173:65-88. 2001
    ..The present study examined the transfer of these chemicals to offspring and placenta. Pregnant Long Evans rats received 0.0 (control), 0.05, 0.2, 0.8, and 1...
  57. ncbi Sensitivity of cortical movement representations to motor experience: evidence that skill learning but not strength training induces cortical reorganization
    M S Remple
    Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Dr, Lethbridge, Alberta, Canada, T1K 3M4
    Behav Brain Res 123:133-41. 2001
    ..These results demonstrate that the development of skilled forelimb movements, but not increased forelimb strength, was associated with a reorganization of forelimb movement representations within motor cortex...
  58. ncbi Expression of inducible nitric oxide synthase and cyclooxygenase-2 after excitotoxic damage to the immature rat brain
    Laia Acarin
    Unit of Histology, School of Medicine, Department of Cell Biology, Physiology and Immunology, Autonomous University of Barcelona, Spain
    J Neurosci Res 68:745-54. 2002
    ....
  59. ncbi Retinal functional development is sensitive to environmental enrichment: a role for BDNF
    S Landi
    Laboratorio di Neurobiologia, Scuola Normale Superiore c o Istituto di Neuroscienze del CNR, Via G Moruzzi, 1, 56100 Pisa, Italy
    FASEB J 21:130-9. 2007
    ..Thus, EE controls the development of retinal circuitry, and this action depends on retinal BDNF expression...
  60. ncbi Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:422-9. 2007
    ..The purpose of the present study was to investigate whether nonproteolytically activated prorenin plays a role in ischemia-induced retinal neovascularization...
  61. ncbi Double dissociation of basolateral and central amygdala lesions on the general and outcome-specific forms of pavlovian-instrumental transfer
    Laura H Corbit
    Department of Psychology and the Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 25:962-70. 2005
    ..Together, these results suggest that the BLA mediates outcome-specific incentive processes, whereas CN is involved in controlling the general motivational influence of reward-related events...
  62. ncbi Neurotoxicity induces cleavage of p35 to p25 by calpain
    M S Lee
    Howard Hughes Medical Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 405:360-4. 2000
    ..Furthermore, inhibition of cdk5 or calpain activity reduces cell death in A beta-treated cortical neurons. These observations indicate that cleavage of p35 to p25 by calpain may be involved in the pathogenesis of Alzheimer's disease...
  63. ncbi Experience-dependent plasticity is impaired in adult rat barrel cortex after whiskers are unused in early postnatal life
    V Rema
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240, USA
    J Neurosci 23:358-66. 2003
    ....
  64. ncbi Sniffing controls an adaptive filter of sensory input to the olfactory bulb
    Justus V Verhagen
    Department of Biology, Boston University, 24 Cummington Street, Boston, Massachusetts 02215, USA
    Nat Neurosci 10:631-9. 2007
    ..Thus, sniffing controls an adaptive filter for detecting changes in the odor landscape. These data suggest an unexpected functional role for sniffing and show that sensory codes can be transformed by sampling behavior alone...
  65. ncbi Neural circuit changes mediating lasting brain and behavioral response to predator stress
    Robert E Adamec
    Dept of Psychology, Memorial University, 232 Elizabeth Ave, St John s, NL, Canada
    Neurosci Biobehav Rev 29:1225-41. 2005
    ..Findings will be discussed within the context of what is known about neural substrates activated by predator odor...
  66. ncbi Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex
    Jeffrey A Kleim
    Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada, T1K 3M4
    Neurobiol Learn Mem 77:63-77. 2002
    ....
  67. ncbi Major dissociation between medial and lateral entorhinal input to dorsal hippocampus
    Eric L Hargreaves
    Department of Neurobiology and Anatomy, W M Keck Center for the Neurobiology of Learning and Memory, Post Office Box 20708, University of Texas Medical School at Houston, Houston, TX 77225, USA
    Science 308:1792-4. 2005
    ....
  68. ncbi Reduced G protein-coupled signaling efficiency in retinal rod outer segments in response to n-3 fatty acid deficiency
    Shui Lin Niu
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20852, USA
    J Biol Chem 279:31098-104. 2004
    ....
  69. ncbi Short and long-term motor skill learning in an accelerated rotarod training paradigm
    Manuel M Buitrago
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, Tubingen 72076, Germany
    Neurobiol Learn Mem 81:211-6. 2004
    ..Accelerated rotarod training can be regarded a valid paradigm for motor skill learning over short (intrasession, minutes) and long time frames (intersession, days)...
  70. pmc Leukocyte-mediated endothelial cell injury and death in the diabetic retina
    A M Joussen
    Laboratory for Surgical Research, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Pathol 158:147-52. 2001
    ..They also underscore the potential utility of anti-intercellular adhesion molecule1- and anti-CD18-based therapies in the treatment of diabetic retinopathy, a newly recognized inflammatory disease...
  71. pmc Direct demonstration of persistent Na+ channel activity in dendritic processes of mammalian cortical neurones
    J Magistretti
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    J Physiol 521:629-36. 1999
    ....
  72. ncbi Inhibition of protein kinase A activity during conditioned taste aversion retrieval: interference with extinction or reconsolidation of a memory?
    Ming Teng Koh
    Department of Psychology, University of Washington, Seattle, WA 98195 1525, USA
    Neuroreport 14:405-7. 2003
    ..Results confirm recent findings that stored memories become more labile when they are retrieved and extend these findings to CTA memories...
  73. pmc Role of resistin in cardiac contractility and hypertrophy
    Maengjo Kim
    Cardiovascular Research Center, Mount Sinai School of Medicine, USA
    J Mol Cell Cardiol 45:270-80. 2008
    ..We conclude that resistin overexpression alters cardiac contractility, confers to primary cardiomyocytes all the features of the hypertrophic phenotype and promotes cardiac hypertrophy possibly via the IRS-1/MAPK pathway...
  74. pmc Grid cells and theta as oscillatory interference: electrophysiological data from freely moving rats
    A Jeewajee
    Institute of Cognitive Neuroscience, University College London UCL, London, United Kingdom
    Hippocampus 18:1175-85. 2008
    ..They also provide specific constraints on this model of grid cell firing and have more general implications for viewing neuronal processing in terms of interfering oscillatory processes...
  75. ncbi Medial prefrontal cortex cells show dynamic modulation with the hippocampal theta rhythm dependent on behavior
    James M Hyman
    Center for Memory and Brain, Department of Psychology, Boston University, Boston, MA 02215, USA
    Hippocampus 15:739-49. 2005
    ..mPFC neurons have the capability to respond to behaviorally relevant elements by dynamically alternating between hippocampal theta entrained and nonphasic firing...
  76. ncbi Temporally graded requirement for protein synthesis following memory reactivation
    Maria H Milekic
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuron 36:521-5. 2002
    ..Here, we show that the requirement for protein synthesis of a reactivated memory is evident only when the memory is recent. In fact, memory vulnerability decreases as the time between the original training and the recall increases...
  77. ncbi Chronic developmental lead exposure reduces neurogenesis in adult rat hippocampus but does not impair spatial learning
    M E Gilbert
    Neurotoxicology Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 86:365-74. 2005
    ..Despite deficits in synaptic plasticity previously reported from our laboratory, and now structural plasticity, no significant impact on spatial learning was detected...
  78. ncbi Cocaine makes actions insensitive to outcomes but not extinction: implications for altered orbitofrontal-amygdalar function
    Geoffrey Schoenbaum
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, HSF 2 S251, Baltimore, MD 21201, USA
    Cereb Cortex 15:1162-9. 2005
    ....
  79. ncbi Long-term effects of light damage on the retina of albino and pigmented rats
    Marguerite Wasowicz
    L Institut National de la Santé et de la Recherche Médicale U 450, Laboratoire de Neuro Cytologie Oculaire, 15 rue de l Ecole de Medecine, 75006 Paris, France
    Invest Ophthalmol Vis Sci 43:813-20. 2002
    ..To observe the morphology and physiology of the retina in rats 11 weeks after a constant (24-hour) but moderate (500-lux) illumination for 1 week...
  80. ncbi Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption
    Tong Zhou
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina, USA
    Toxicol Sci 66:105-16. 2002
    ..8-fold; UDPGT = 0.5-fold). These data support the conclusion that DE-71 is an endocrine disrupter in rats during development...
  81. pmc Role of food type in yohimbine- and pellet-priming-induced reinstatement of food seeking
    S G Nair
    Behavioral Neuroscience Branch, IRP NIDA NIH DHHS, National Institutes of Health, Baltimore, MD 21224, USA
    Physiol Behav 88:559-66. 2006
    ..Results suggest that the magnitude of the effect of yohimbine and pellet priming on reinstatement of food seeking depends in part on the composition of the food pellets used during training...
  82. ncbi Spatial segregation of different modes of movement control in the whisker representation of rat primary motor cortex
    Florent Haiss
    Abteilung für Kognitive Neurologie, Hertie Institut für Klinische Hirnforschung, Universitat Tubingen, 72076 Tubingen, Germany
    J Neurosci 25:1579-87. 2005
    ..Therefore, we suggest that the cause of cortical separation is the specific drive of subcortical structures needed to generate different types of movements rather than different behavioral contexts in which the movements are performed...
  83. ncbi Theta phase-specific codes for two-dimensional position, trajectory and heading in the hippocampus
    John R Huxter
    MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
    Nat Neurosci 11:587-94. 2008
    ..This represents the first direct evidence of a combined representation of position, trajectory and heading in the hippocampus, organized on a fine temporal scale by theta oscillations...
  84. ncbi Cholinergic suppression of excitatory synaptic responses in layer II of the medial entorhinal cortex
    Bassam N Hamam
    Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Hippocampus 17:103-13. 2007
    ....
  85. ncbi Cone-based vision of rats for ultraviolet and visible lights
    G H Jacobs
    Neuroscience Research Institute and Department of Psychology, University of California, Santa Barbara 93106, USA
    J Exp Biol 204:2439-46. 2001
    ..Evidence of dichromatic color vision in the rat was subsequently obtained from tests of wavelength discrimination...
  86. ncbi The anxiogenic drug yohimbine reinstates methamphetamine seeking in a rat model of drug relapse
    Jack D Shepard
    Cellular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Biol Psychiatry 55:1082-9. 2004
    ..We studied whether yohimbine, an alpha-2 adrenoceptor antagonist that increases noradrenaline release and induces anxiety-like responses in human and nonhuman subjects, would reinstate methamphetamine seeking in rats...
  87. ncbi Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons
    J K Seamans
    Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 21:3628-38. 2001
    ..This bidirectional modulation could have important implications for the computational properties of active PFC networks...
  88. ncbi Oscillatory entrainment of striatal neurons in freely moving rats
    Joshua D Berke
    Laboratory of Cognitive Neurobiology, Department of Psychology, Boston University, Boston, MA 02215, USA
    Neuron 43:883-96. 2004
    ..The orchestration of oscillatory activity by networks of striatal interneurons may be an important mechanism in the pathophysiology of neurological disorders such as Parkinson's disease...
  89. ncbi Phagocyte-derived catecholamines enhance acute inflammatory injury
    Michael A Flierl
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nature 449:721-5. 2007
    ..We were able to exclude T cells or sympathetic nerve endings as sources of the injury-modulating catecholamines. Our studies identify phagocytes as a new source of catecholamines, which enhance the inflammatory response...
  90. ncbi Behavioral properties of the trigeminal somatosensory system in rats performing whisker-dependent tactile discriminations
    D J Krupa
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 21:5752-63. 2001
    ....
  91. ncbi Docosapentaenoic acid does not completely replace DHA in n-3 FA-deficient rats during early development
    Rebecca S Greiner
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, USA
    Lipids 38:431-5. 2003
    ..The lack of total 22-carbon (22C) FA in the brain during the rapid membrane biogenesis that occurs during early development could be a factor in the nervous system functional deficits associated with n-3 FA deficiency...
  92. pmc Development of theta rhythmicity in entorhinal stellate cells of the juvenile rat
    Brian G Burton
    Department of Biomedical Engineering, Center for Memory and Brain, Center for BioDynamics, Boston University, Boston, Massachusetts, USA
    J Neurophysiol 100:3144-57. 2008
    ..Our data predict that functions that rely on theta rhythmicity in the hippocampal network are limited until at least P18...
  93. ncbi Experience-dependent asymmetric shape of hippocampal receptive fields
    M R Mehta
    Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 25:707-15. 2000
    ....
  94. ncbi NKCC1 transporter facilitates seizures in the developing brain
    Volodymyr I Dzhala
    Department of Neurology, School of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Nat Med 11:1205-13. 2005
    ..Our results provide evidence that NKCC1 facilitates seizures in the developing brain and indicate that bumetanide should be useful in the treatment of neonatal seizures...
  95. ncbi Relationship of the predatory attack experience to neural plasticity, pCREB expression and neuroendocrine response
    Robert E Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Ave, St John s, NL, Canada, A1B 3X9
    Neurosci Biobehav Rev 30:356-75. 2006
    ....
  96. ncbi Phase precession of medial prefrontal cortical activity relative to the hippocampal theta rhythm
    Matthew W Jones
    Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Hippocampus 15:867-73. 2005
    ..The existence of phase precession beyond the hippocampus implies a more global role for this phenomenon during theta rhythm-mediated coordination of neural activity...
  97. ncbi Acetylcholine release is elicited in the visual cortex, but not in the prefrontal cortex, by patterned visual stimulation: a dual in vivo microdialysis study with functional correlates in the rat brain
    F Laplante
    Douglas Hospital Research Center, McGill University, 6875 Boul LaSalle, Montreal, Quebec, H4H 1R3 Canada
    Neuroscience 132:501-10. 2005
    ..These results suggest the differential involvement of cholinergic projections in the integration of sensory stimuli, depending on the level of activity of the targeted cortical area...
  98. ncbi Heterosynaptic facilitation of in vivo thalamocortical long-term potentiation in the adult rat visual cortex by acetylcholine
    Hans C Dringenberg
    Department of Psychology and Centre for Neuroscience Studies, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Cereb Cortex 17:839-48. 2007
    ..We conclude that heterosynaptic facilitation of V1 plasticity by ACh extends beyond early postnatal maturation periods and acts to convert weak potentiation into pronounced, long-lasting increases in synaptic strength...
  99. ncbi Cortical stimulation mapping using epidurally implanted thin-film microelectrode arrays
    Katiuska Molina-Luna
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    J Neurosci Methods 161:118-25. 2007
    ..EMS is specifically suitable for experiments integrating electrophysiology with behavioral and molecular biology techniques...
  100. ncbi Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress
    Danielle L Champagne
    Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurosci 28:6037-45. 2008
    ....
  101. ncbi Gender-dependent behavioral and sensory effects of a commercial mixture of polychlorinated biphenyls (Aroclor 1254) in rats
    A M Geller
    Neurotoxicology Division, MD 74B, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 59:268-77. 2001
    ..These data extend previous findings of gender-specific effects of PCBs on neurobehavioral development to measures of acquisition and sensory function...

Research Grants62

  1. Neural Substrates of Oral Motor Dysfunction in Parkinson's Disease
    EMILY KATE PRINE; Fiscal Year: 2010
    ..This study involves first training 90 male Long Evans rats on an extensive battery of motor tasks to establish a baseline measure of upper extremity and oral motor ..
  2. Synaptic and Behavioral Correlates of Early Life Stress in the BLA
    Mary Jane Skelly; Fiscal Year: 2013
    ....
  3. Prevention of RGC loss in an in vitro excitotoxic model and an in vivo model of g
    Cindy L Linn; Fiscal Year: 2012
    ..In culture studies, rat retinas obtained from Long Evans rats will be enzymatically dissociated and cultured using various concentrations of the agonist for different ..
  4. Synaptic plasticity in young versus aged visual cortex
    ELIZABETH MARY QUINLAN; Fiscal Year: 2013
    ..we use chronic monocular deprivation from eye opening to adulthood to induce severe amblyopia in pigmented Long Evans rats, and demonstrate that dark exposure in adulthood promotes the experience-dependent recovery of spatial acuity ..
  5. Development of a biodegradable load-bearing DBM carrier
    TIEN MIN CHU; Fiscal Year: 2006
    ..The ultimate force (Fu; N), stiffness (S; N/mm) and energy to ultimate force (U; N.mm) will be compared between the control and the DBM treated groups. ..
  6. The role of the endogenous cannabinoid system in ethanol self-administration
    Regina A Mangieri; Fiscal Year: 2010
    ..The first aim will measure the effect of operant ethanol self-administration by Long Evans rats on extracellular levels of the two endocannabinoids anandamide and 2-AG, as measured by in vivo microdialysis,..
  7. COGNITION AND HIPPOCAMPAL/CORTICAL SYSTEMS IN AGING
    Michela Gallagher; Fiscal Year: 2013
    ..with neurobiological analyses conducted against the background of cognitive assessment using healthy male Long Evans rats. The broad spectrum of cognitive outcomes at older ages (24-28 mo) in this study population consists of ..
  8. The development of topographic maps and connectivity in M1 and S1 of rats
    ADELE MARY HANDLEY SEELKE; Fiscal Year: 2010
    ..This information may then be used to develop novel approaches to the diagnosis and treatment of traumatic brain injury and other neurological disorders. ..
  9. NEUROAMINES OF BEER DRINKING RATS AND THEIR OFFSPRING
    FRANCINE LANCASTER; Fiscal Year: 1991
    ..Male and female Long Evans rats (85 days old) will be tested for preference for beer and assigned to the beer group (BR) if greater than 50 ..
  10. GLIAL ACTIVATION IN AGED MEMORY IMPAIRED RATS
    Kiminobu Sugaya; Fiscal Year: 1999
    ..Subsequently, if we establish a relationship between memory impairment and glial activation in this animal model, it will be a good tool to develop noel therapeutics based on regulation of glial activity. ..
  11. INDIVIDUAL DIFFERENCES AND ADDICTIVE VULNERABILITY
    Douglas Ramsay; Fiscal Year: 2000
    ..These studies have theoretical importance for understanding the mechanisms of drug tolerance as well as what accounts for individual differences in vulnerability to addiction and drug abuse. ..
  12. Involvement of Permeability Transition Pore in Developmental Alcohol Neurotoxicit
    MARIETA HEATON; Fiscal Year: 2009
    ....
  13. FUNCTIONS OF UBIQUITINYLATION IN THE MAMMALIAN RETINA
    Martin Obin; Fiscal Year: 2001
    ....
  14. Ethanol and Neurophysiology of the Mesolimbic System
    Donald Woodward; Fiscal Year: 2006
    ..Normal Long Evans rats will be compared with the inbred P (ethanol-preferring) rats to be obtained from the Center for Ethanol ..
  15. Sensory stimuli of ethanol elicits dopamine signals in the accumbens core
    Jennifer Carrillo; Fiscal Year: 2009
    ..For both aims, Long Evans Rats will be used and microdialysis will be done to test our hypotheses...
  16. DEVELOPMENT OF INDIVIDUAL CHAMBERS FOR ALCOHOL DELIVERY
    Maury Cole; Fiscal Year: 2003
    ..PROPOSED COMMERCIAL APPLICATION: Not available ..
  17. NEUROCHEMICAL MECHANISMS OF ETHANOL SELF-ADMINISTRATION
    RUEBEN GONZALES; Fiscal Year: 2007
    ..consumption on dopamine release in vivo in the prefrontal cortex and nucleus accumbens (core and shell) of Long Evans rats at early phases in the development of reinforcement, (2) the effects of ethanol through i.v...
  18. Northeast Under/Grad Research Organization for Neuroscience
    Cheryl Frye; Fiscal Year: 2008
    ..Both of these outcomes are congruous with the Public Health Service's mission to ensure that there is a resource of well-trained scientists and health-care providers in the United States. [unreadable] [unreadable] [unreadable]..
  19. Brain cooling and reperfusion injury in stroke
    THADDEUS NOWAK; Fiscal Year: 2004
    ..These results will establish the relative accessibility of intravascular vs. parenchymal injury cascades to hypothermic protection, and define critical targets for pharmacological intervention. ..
  20. MODEL OF PARKINSON'S DISEASE
    George Wagner; Fiscal Year: 1990
    ..The demonstration that rodents with MPTP or methamphetamine-induced dopaminergic lesions do exhibit behavioral deficits has provided support for the validity of these models...
  21. Brain DHA, Dopamine, and Behavior: Roles in ADHD
    Beth Levant; Fiscal Year: 2006
    ..Such insights may identify a means by which certain risk factors for ADHD may be reduced or eliminated or the severity of the disease may be reduced through appropriate pre- and postnatal nutrition. [unreadable] [unreadable]..
  22. Brain LC-PUFAs and Maternal Mental Health
    Beth Levant; Fiscal Year: 2006
    ..These findings will also suggest novel treatments for such illnesses when they occur. ..
  23. Role of amygdala systems in associative learning
    Peter Holland; Fiscal Year: 2005
    ..abstract_text> ..
  24. Associatively-activated event representations
    Peter Holland; Fiscal Year: 2006
    ..The proposed research provides a basis for the understanding of basic processing of imaginal events in associative learning. ..
  25. AAS and the Neurobiology of Social Behaviors
    Ann Clark; Fiscal Year: 2009
    ..Such data may be relevant towards understanding not only the effects of AAS, but of other abused drugs that act via GABAergic pathways. ..
  26. NEURAL AND BEHAVIORAL ACTIONS OF ANABOLIC STEROIDS
    Ann Clark; Fiscal Year: 2003
    ....
  27. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal R Swerdlow; Fiscal Year: 2010
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  28. Neural basis of heritable DA-mediated gating deficits
    Neal R Swerdlow; Fiscal Year: 2010
    ....
  29. Neuroscience at the Boundaries of Neurology and Psychiatry
    Neal Swerdlow; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  30. A Simple Measure for Studying Sensory Gating Deficits
    Neal Swerdlow; Fiscal Year: 2007
    ..abstract_text> ..
  31. NEURAL CIRCUITRY OF SENSORIMOTOR GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2006
    ....
  32. Errors and Expectancies in OFC and VTA and their Roles in Associative Learning
    GEOFFREY M SCHOENBAUM; Fiscal Year: 2010
    ..This proposal will test this hypothesis, using inactivation and single-unit recording to ask how OFC is involved learning and in the calculation of prediction errors in dopaminergic VTA neurons during Pavlovian blocking. ..
  33. LONG TERM HIPPOCAMPAL MEMORY
    Pramod Dash; Fiscal Year: 2001
    ..Understanding the molecular basis of memory storage will be of value in the future development of pharmacological agents to treat amnesia associated with neurological disorders and other mental health related problems. ..
  34. Working memory deficits following brain trauma
    Pramod Dash; Fiscal Year: 2009
    ..An understanding of the mechanisms by which TBI alters dopamine signaling is critical for the development of mechanism-based intelligent pharmacological treatments for working memory deficits for brain trauma patients. ..
  35. Prefrontal cortex and memory storage
    Pramod K Dash; Fiscal Year: 2010
    ....
  36. ETHANOL, INSULIN/IGF SIGNALING AND NEURONAL MIGRATION
    Suzanne de la Monte; Fiscal Year: 2008
    ..abstract_text> ..
  37. MECHANISMS OF MEMORY DEFICITS FOLLOWING BRAIN INJURY
    Pramod Dash; Fiscal Year: 2006
    ..Furthermore, this project will broaden our understanding of the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. ..
  38. Linking Affect to Action: Critical Contributions of the Orbitofrontal Cortex
    Geoffrey Schoenbaum; Fiscal Year: 2006
    ..The participation of minorities and women has been emphasized at each level (organizers, speakers, students). Thus the conference will address important scientific, social, and educational issues. [unreadable] [unreadable] [unreadable]..
  39. Neural Mechanisms of Inhibitory Classical Conditioning
    John Freeman; Fiscal Year: 2007
    ..The results of these studies may also lead to a better understanding of the functional pathology associated with various psychiatric disorders that involve deficits in behavioral inhibition. ..
  40. Improving memory after hippocampal cell loss
    MARK BARDGETT; Fiscal Year: 2007
    ..The results may shed light on new directions in the treatment of memory disorders, and the proposed work will also enhance education in biomedical research among college undergraduates in Kentucky. [unreadable] [unreadable] [unreadable]..
  41. Prenatal ethanol, social behavior, and prefrontal cortex
    Derek Hamilton; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  42. Ethanol, neurotrophins, and thalamocortical matching
    SANDRA MOONEY; Fiscal Year: 2006
    ..abstract_text> ..
  43. Steroids and GABA: Physiology of Receptor Subunit Change
    Sheryl S Smith; Fiscal Year: 2010
    ..These results may be relevant for alterations in mood, cognition and seizure susceptibility (i.e., catamenial epilepsy) reported during puberty and across the menstrual cycle. ..
  44. MECHANISM OF INDUCTION OF OLFACTORY TUMORS BY ALACHLOR
    Mary Beth Genter; Fiscal Year: 2002
    ....
  45. Determinants of Tolerance to Nitrous Oxide Hypothermia
    Karl Kaiyala; Fiscal Year: 2004
    ..These studies have theoretical importance for understanding the mechanisms of drug tolerance and will begin to suggest the physiological basis of individual differences in vulnerability to addiction and drug abuse. ..
  46. Brain Fatty Acid Composition and PKC Activity
    Robert McNamara; Fiscal Year: 2007
    ..The proposed experiments are innovative and exploratory in that the effect of altered DHA concentrations on PKC and dopamine D2 receptor expression have not been systematically examined in brain. [unreadable] [unreadable] [unreadable]..
  47. AMYGDALOID FUNCTION IN FEAR CONDITIONING
    Stephen Maren; Fiscal Year: 2002
    ..The outcome of these experiments will have an important impact on current conceptions of both amygdaloid function and emotional learning and memory. ..
  48. CNS AND SALT APPETITE
    DOUGLAS FITTS; Fiscal Year: 2004
    ..The results will have implications for the central control of blood pressure and endocrine secretions as well as behavior during various challenges to body hydration. ..
  49. Effects of Androgens and Cannabinoids on Learning
    STUART LEONARD; Fiscal Year: 2005
    ..These results will provide, for the first time, information regarding the interactive effects of testosterone and THC on cognitive behavior. ..
  50. Striatal Acetylcholine and Behavioral Flexibility
    MICHAEL RAGOZZINO; Fiscal Year: 2005
    ....
  51. Sphingolipid signaling in olfactory mucosa
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  52. Neuroadaptive Substrates for Nitrous Oxide Tolerance
    Karl Kaiyala; Fiscal Year: 2006
    ..This work will be the first to identify brain areas activated by a drug-induced hypothermic stimulus and its adaptive consequences. These studies have theoretical importance for understanding and treating drug addiction. ..
  53. Aging, Serotonin and Reversal Learning
    MICHAEL RAGOZZINO; Fiscal Year: 2008
    ..These studies have the potential of developing a novel treatment for the learning and memory deficits observed in aging and Alzheimer's disease. [unreadable] [unreadable] [unreadable]..
  54. Antipsychotic-Like Drug Effects of Neurotensin
    David Feifel; Fiscal Year: 2004
    ....
  55. Neural Control of Sodium Balance in Hypertension: Exercise
    Noreen Rossi; Fiscal Year: 2009
    ..These studies will provide data to direct strategic pharmacologic and nonpharmacologic interventions for cardiovascular health that may be readily translated into clinical practice. ..
  56. A Novel Animal Model of Relevance to Schizophrenia
    David Feifel; Fiscal Year: 2009
    ..The successful development of this animal model could significantly enhance the understanding of the underlying causes of schizophrenia-associated abnormalities and improve drug discovery. ..
  57. Omega-3 Fatty Acid Deficient Rat Model of Schizophrenia
    Robert McNamara; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. BACTERIAL MODULATION OF LUNG INFLAMMATORY RESPONSE
    Thomas Russo; Fiscal Year: 2004
    ..g. hemolysin) and bacterially induced host response elements in directly mediating the pathogenesis of lung injury. ..
  59. ALCOHOL, GABA AND HORMONES: PHYSIOLOGY OF SUBUNIT CHANGE
    Sheryl S Smith; Fiscal Year: 2010
    ..The results from these studies may provide insight into potential mechanisms for effects of low dose ethanol at GABAR. ..
  60. Role of the Cholinergic system in spatial orientation
    Douglas Wallace; Fiscal Year: 2006
    ..These studies will advance our understanding of the neural basis of spatial orientation, and the results may have implications for developing treatments for TD. [unreadable] [unreadable]..
  61. Extracellular matrix in chloracetanilide carcinogenesis
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..