rats

Summary

Summary: The common name for the genus Rattus.

Top Publications

  1. ncbi Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    Benjamin P Lewis
    Cell 120:15-20. 2005
  2. pmc LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    Y Kabeya
    Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, PRESTO, Japan
    EMBO J 19:5720-8. 2000
  3. pmc Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
    Michael W Pfaffl
    Institute of Physiology, FML Weihenstephan, Center of Life and Food Sciences, Technical University of Munich, Germany
    Nucleic Acids Res 30:e36. 2002
  4. ncbi Quantitative assessment of tactile allodynia in the rat paw
    S R Chaplan
    Department of Anesthesiology, University of California, San Diego, La Jolla 92093 0818
    J Neurosci Methods 53:55-63. 1994
  5. ncbi Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    M Kojima
    Department of Biochemistry, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Nature 402:656-60. 1999
  6. ncbi A neural substrate of prediction and reward
    W Schultz
    Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Science 275:1593-9. 1997
  7. ncbi Epigenetic programming by maternal behavior
    Ian C G Weaver
    Douglas Hospital Research Center, 6875 LaSalle Blvd, Montreal, Quebec H4H 1R3, Canada
    Nat Neurosci 7:847-54. 2004
  8. ncbi Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    P Chomczynski
    Anal Biochem 162:156-9. 1987
  9. ncbi Pluripotency of mesenchymal stem cells derived from adult marrow
    Yuehua Jiang
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 418:41-9. 2002
  10. doi MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
    Thomas Thum
    Department of Medicine I, Interdisziplinares Zentrum fur Klinische Forschung IZKF, University of Wuerzburg, 97080 Wuerzburg, Germany
    Nature 456:980-4. 2008

Detail Information

Publications436 found, 100 shown here

  1. ncbi Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    Benjamin P Lewis
    Cell 120:15-20. 2005
    ..Targeting was also detected in open reading frames. In sum, well over one third of human genes appear to be conserved miRNA targets...
  2. pmc LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    Y Kabeya
    Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, PRESTO, Japan
    EMBO J 19:5720-8. 2000
    ..The amount of LC3-II is correlated with the extent of autophagosome formation. LC3-II is the first mammalian protein identified that specifically associates with autophagosome membranes...
  3. pmc Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
    Michael W Pfaffl
    Institute of Physiology, FML Weihenstephan, Center of Life and Food Sciences, Technical University of Munich, Germany
    Nucleic Acids Res 30:e36. 2002
    ..The latest software version of REST and examples for the correct use can be downloaded at http://www.wzw.tum.de/gene-quantification/...
  4. ncbi Quantitative assessment of tactile allodynia in the rat paw
    S R Chaplan
    Department of Anesthesiology, University of California, San Diego, La Jolla 92093 0818
    J Neurosci Methods 53:55-63. 1994
    ..4 g (1.81-2.76). Correlation coefficient between the two methods was 0.91. In neuropathic rats, good intra- and inter-observer reproducibility was found for the up-down paradigm; some variability was seen in ..
  5. ncbi Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    M Kojima
    Department of Biochemistry, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Nature 402:656-60. 1999
    ..Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin...
  6. ncbi A neural substrate of prediction and reward
    W Schultz
    Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Science 275:1593-9. 1997
    ..Taken together, these findings can be understood through quantitative theories of adaptive optimizing control...
  7. ncbi Epigenetic programming by maternal behavior
    Ian C G Weaver
    Douglas Hospital Research Center, 6875 LaSalle Blvd, Montreal, Quebec H4H 1R3, Canada
    Nat Neurosci 7:847-54. 2004
    ..Thus we show that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible...
  8. ncbi Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    P Chomczynski
    Anal Biochem 162:156-9. 1987
    ..It is particularly useful for processing large numbers of samples and for isolation of RNA from minute quantities of cells or tissue samples...
  9. ncbi Pluripotency of mesenchymal stem cells derived from adult marrow
    Yuehua Jiang
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 418:41-9. 2002
    ..As MAPCs proliferate extensively without obvious senescence or loss of differentiation potential, they may be an ideal cell source for therapy of inherited or degenerative diseases...
  10. doi MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
    Thomas Thum
    Department of Medicine I, Interdisziplinares Zentrum fur Klinische Forschung IZKF, University of Wuerzburg, 97080 Wuerzburg, Germany
    Nature 456:980-4. 2008
    ..Our results validate miR-21 as a disease target in heart failure and establish the therapeutic efficacy of microRNA therapeutic intervention in a cardiovascular disease setting...
  11. ncbi Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
    G Miesenbock
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nature 394:192-5. 1998
    ..When linked to a vesicle membrane protein, pHluorins were sorted to secretory and synaptic vesicles and reported transmission at individual synaptic boutons, as well as secretion and fusion pore 'flicker' of single secretory granules...
  12. ncbi Developments of a water-maze procedure for studying spatial learning in the rat
    R Morris
    J Neurosci Methods 11:47-60. 1984
    Developments of an open-field water-maze procedure in which rats learn to escape from opaque water onto a hidden platform are described...
  13. ncbi Prediction of mammalian microRNA targets
    Benjamin P Lewis
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 115:787-98. 2003
    ..The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions...
  14. ncbi Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    D L Lacey
    Department of Pathology, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Cell 93:165-76. 1998
    ..These data suggest that OPGL is an osteoclast differentiation and activation factor. The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGL and OPG are key extracellular regulators of osteoclast development...
  15. ncbi Millisecond-timescale, genetically targeted optical control of neural activity
    Edward S Boyden
    Department of Bioengineering, Stanford University, 318 Campus Drive West, Stanford, California 94305, USA
    Nat Neurosci 8:1263-8. 2005
    ..This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers...
  16. ncbi Biologic basis for interleukin-1 in disease
    C A Dinarello
    Department of Medicine, Tufts University, Boston, MA USA
    Blood 87:2095-147. 1996
    ..At the end of each section, a short commentary summarizes what the author considers established or controversial topics linking the biology of IL-1 to mechanisms of disease...
  17. pmc Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
    Caroline Vance
    Department of Clinical Neuroscience, King s College London, Medical Research Council MRC Centre for Neurodegeneration Research, Institute of Psychiatry, London SE5 8AF, UK
    Science 323:1208-11. 2009
    ..FUS is involved in the regulation of transcription and RNA splicing and transport, and it has functional homology to another ALS gene, TARDBP, which suggests that a common mechanism may underlie motor neuron degeneration...
  18. ncbi Place navigation impaired in rats with hippocampal lesions
    R G Morris
    Nature 297:681-3. 1982
  19. ncbi A specific amyloid-beta protein assembly in the brain impairs memory
    Sylvain Lesne
    Department of Neurology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 440:352-7. 2006
    ..Abeta*56 purified from the brains of impaired Tg2576 mice disrupts memory when administered to young rats. We propose that Abeta*56 impairs memory independently of plaques or neuronal loss, and may contribute to cognitive ..
  20. ncbi Ghrelin induces adiposity in rodents
    M Tschop
    Endocrine Research and BioResearch Technologies and Proteins, Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Nature 407:908-13. 2000
    ..we show that peripheral daily administration of ghrelin caused weight gain by reducing fat utilization in mice and rats. Intracerebroventricular administration of ghrelin generated a dose-dependent increase in food intake and body ..
  21. pmc A third-generation lentivirus vector with a conditional packaging system
    T Dull
    Cell Genesys, Foster City, California 94404, USA
    J Virol 72:8463-71. 1998
    ..While the actual biosafety of the vector will ultimately be proven in vivo, the improved design presented here should facilitate testing of lentivirus vectors...
  22. ncbi Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
    W S Simonet
    Department of Molecular Genetics, Amgen Inc, Thousand Oaks, California 91320, USA
    Cell 89:309-19. 1997
    ..Furthermore, OPG blocks ovariectomy-associated bone loss in rats. These data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in ..
  23. ncbi C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    A C Epstein
    The Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Cell 107:43-54. 2001
    ....
  24. ncbi A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
    Sebastien Bonnet
    Pulmonary Hypertension Program and Vascular Biology Group, Department of Physiology, University of Alberta, Edmonton, AB T6G 2B7, Canada
    Cancer Cell 11:37-51. 2007
    ..Molecular inhibition of PDK2 by siRNA mimics DCA. The mitochondria-NFAT-Kv axis and PDK are important therapeutic targets in cancer; the orally available DCA is a promising selective anticancer agent...
  25. ncbi Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    Dominic M Walsh
    Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nature 416:535-9. 2002
    ..and abundant Abeta monomers but no amyloid fibrils markedly inhibited hippocampal long-term potentiation (LTP) in rats in vivo. Immunodepletion from the medium of all Abeta species completely abrogated this effect...
  26. pmc Lifeact: a versatile marker to visualize F-actin
    Julia Riedl
    Max Planck Institute of Biochemistry, Independent Junior Research Group Cellular Dynamics and Cell Patterning, Am Klopferspitz 18, 82152 Martinsried, Germany
    Nat Methods 5:605-7. 2008
    ..Lifeact did not interfere with actin dynamics in vitro and in vivo and in its chemically modified peptide form allowed visualization of actin dynamics in nontransfectable cells...
  27. ncbi SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
    Gareth J Inman
    Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, London, UK
    Mol Pharmacol 62:65-74. 2002
    ..SB-431542 has no effect on components of the ERK, JNK, or p38 MAP kinase pathways or on components of the signaling pathways activated in response to serum...
  28. pmc Highly nonrandom features of synaptic connectivity in local cortical circuits
    Sen Song
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Biol 3:e68. 2005
    ..Therefore, the local cortical network structure can be viewed as a skeleton of stronger connections in a sea of weaker ones. Such a skeleton is likely to play an important role in network dynamics and should be investigated further...
  29. ncbi MicroRNA-133 controls cardiac hypertrophy
    Alessandra Carè
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanita, 00161 Rome, Italy
    Nat Med 13:613-8. 2007
    ..Our data show that miR-133, and possibly miR-1, are key regulators of cardiac hypertrophy, suggesting their therapeutic application in heart disease...
  30. pmc A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
    Christopher B Newgard
    Sarah W Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA
    Cell Metab 9:311-26. 2009
    ..To test its impact on metabolic homeostasis, we fed rats on high-fat (HF), HF with supplemented BCAA (HF/BCAA), or standard chow (SC) diets...
  31. ncbi Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    Paola Scaffidi
    DIBIT, Istituto Scientifico San Raffaele, 20132 Milano, Italy
    Nature 418:191-5. 2002
    ..Thus, cells undergoing apoptosis are programmed to withhold the signal that is broadcast by cells that have been damaged or killed by trauma...
  32. ncbi A brain-specific microRNA regulates dendritic spine development
    Gerhard M Schratt
    Neurobiology Program, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 439:283-9. 2006
    ..Exposure of neurons to extracellular stimuli such as brain-derived neurotrophic factor relieves miR-134 inhibition of Limk1 translation and in this way may contribute to synaptic development, maturation and/or plasticity...
  33. pmc Knockout rats via embryo microinjection of zinc-finger nucleases
    Aron M Geurts
    Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 52336, USA
    Science 325:433. 2009
    ..Our data demonstrate the feasibility of targeted gene disruption in multiple rat strains within 4 months time, paving the way to a humanized monoclonal antibody platform and additional human disease models...
  34. ncbi Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors
    Carlos Lois
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 295:868-72. 2002
    ..We have also generated transgenic rats that express GFP at high levels, suggesting that this technique can be used to produce other transgenic animal ..
  35. ncbi Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
    Vincenzo Bonifati
    Genetic Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands
    Science 299:256-9. 2003
    ..Elucidating the physiological role of DJ-1 protein may promote understanding of the mechanisms of brain neuronal maintenance and pathogenesis of Parkinson's disease...
  36. ncbi Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
    ..The existence of these cells opens new opportunities for myocardial repair...
  37. pmc The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
    L de Lecea
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 95:322-7. 1998
    ..One of the Hcrt peptides was excitatory when applied to cultured, synaptically coupled hypothalamic neurons, but not hippocampal neurons. These observations suggest that the hypocretins function within the CNS as neurotransmitters...
  38. ncbi Nitric oxide and the immune response
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, Friedrich Alexander University of Erlangen Nuremberg, Wasserturmstrasse 3 5, D 91054 Erlangen, Germany
    Nat Immunol 2:907-16. 2001
    ..Its striking inter- and intracellular signaling capacity makes it extremely difficult to predict the effect of NOS inhibitors and NO donors, which still hampers therapeutic applications...
  39. ncbi A role for ghrelin in the central regulation of feeding
    M Nakazato
    Third Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Japan
    Nature 409:194-8. 2001
    ..Intracerebroventricular injections of ghrelin strongly stimulated feeding in rats and increased body weight gain...
  40. pmc A MicroRNA feedback circuit in midbrain dopamine neurons
    Jongpil Kim
    Departments of Pathology and Neurology, Center for Neurobiology and Behavior, and Taub Institute, Columbia University, College of Physicians and Surgeons 15 403, 630 West 168th Street, New York, NY 10032, USA
    Science 317:1220-4. 2007
    ..We propose a role for this feedback circuit in the fine-tuning of dopaminergic behaviors such as locomotion...
  41. pmc Leptospirosis
    P N Levett
    University of the West Indies, School of Clinical Medicine and Research, and Leptospira Laboratory, Ministry of Health, Barbados
    Clin Microbiol Rev 14:296-326. 2001
    ....
  42. pmc The RIN: an RNA integrity number for assigning integrity values to RNA measurements
    Andreas Schroeder
    Agilent Technologies, Hewlett Packard Strasse 8, 76337 Waldbronn, Germany
    BMC Mol Biol 7:3. 2006
    ..The advent of microcapillary electrophoretic RNA separation provides the basis for an automated high-throughput approach, in order to estimate the integrity of RNA samples in an unambiguous way...
  43. ncbi A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress
    Michael Boyce
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 307:935-9. 2005
    ..More broadly, salubrinal demonstrates the feasibility of selective pharmacological targeting of cellular dephosphorylation events...
  44. ncbi Glutamate uptake
    N C Danbolt
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1105, Blindern, N-0317, Oslo, Norway
    Prog Neurobiol 65:1-105. 2001
    ..g. osteoporosis) can be properly understood unless more is learned about these transporter proteins. Like glutamate itself, glutamate transporters are somehow involved in almost all aspects of normal and abnormal brain activity...
  45. pmc Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data
    Manhong Dai
    Molecular and Behavioural Neuroscience Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
    Nucleic Acids Res 33:e175. 2005
    ..It will be beneficial to re-analyze existing GeneChip data with updated probe set definitions...
  46. pmc A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure
    Eva van Rooij
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 103:18255-60. 2006
    ....
  47. ncbi Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment
    Stephen B Long
    Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 450:376-82. 2007
    ..The detailed structure, which can be compared directly to a large body of functional data, explains charge stabilization within the membrane and suggests a mechanism for voltage-sensor movements and pore gating...
  48. pmc Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein
    Paula Desplats
    Department of Neurosciences and Pathology, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:13010-5. 2009
    ..These findings demonstrate the cell-to-cell transmission of alpha-synuclein aggregates and provide critical insights into the mechanism of pathological progression in PD and other proteinopathies...
  49. ncbi Neuronal replacement from endogenous precursors in the adult brain after stroke
    Andreas Arvidsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
    Nat Med 8:963-70. 2002
    ..Here we show that stroke, caused by transient middle cerebral artery occlusion in adult rats, leads to a marked increase of cell proliferation in the subventricular zone...
  50. doi Guidelines for assessment of bone microstructure in rodents using micro-computed tomography
    Mary L Bouxsein
    Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Bone Miner Res 25:1468-86. 2010
    ..Other variables also may be appropriate depending on the research question and technical quality of the scan. Standard nomenclature, outlined in this article, should be followed for reporting of results...
  51. ncbi The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator
    Nicolas Preitner
    Department of Molecular Biology, Sciences II, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 4, Geneva, Switzerland
    Cell 110:251-60. 2002
    ..While REV-ERBalpha influences the period length and affects the phase-shifting properties of the clock, it is not required for circadian rhythm generation...
  52. ncbi Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Science 305:1292-5. 2004
    ..These findings may underlie the toxic gain-of-function by the mutants...
  53. ncbi Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring
    Karen A Lillycrop
    Development and Cell Biology, University of Southampton, UK
    J Nutr 135:1382-6. 2005
    ..Epigenetic regulation of gene transcription provides a strong candidate mechanism for fetal programming...
  54. ncbi Cellular survival: a play in three Akts
    S R Datta
    Division of Neuroscience, Children s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115 USA
    Genes Dev 13:2905-27. 1999
  55. ncbi A sensitive and reliable locomotor rating scale for open field testing in rats
    D M Basso
    Department of Cell Biology, Neurobiology and Anatomy, Ohio State University, Columbus, USA
    J Neurotrauma 12:1-21. 1995
    ..Adult rats (n = 85) were contused at T7-9 cord level with an electromagnetic or weight drop device...
  56. ncbi Multimodal fast optical interrogation of neural circuitry
    Feng Zhang
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 446:633-9. 2007
    ..NpHR and ChR2 form a complete system for multimodal, high-speed, genetically targeted, all-optical interrogation of living neural circuits...
  57. ncbi Molecular characterization of mitochondrial apoptosis-inducing factor
    S A Susin
    Centre National de la Recherche Scientifique, UPR 420, Villejuif, France
    Nature 397:441-6. 1999
    ..These results indicate that AIF is a mitochondrial effector of apoptotic cell death...
  58. pmc Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    J A Forsythe
    Department of Physiology, University of Maryland School of Medicine, Baltimore, 21201, USA
    Mol Cell Biol 16:4604-13. 1996
    ..VEGF mRNA was not induced by hypoxia in mutant cells that do not express the HIF-1beta (ARNT) subunit. These findings implicate HIF-1 in the activation of VEGF transcription in hypoxic cells...
  59. pmc TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes
    V Matys
    BIOBASE GmbH, Halchtersche Strasse 33, D 38304 Wolfenbuttel, Germany
    Nucleic Acids Res 34:D108-10. 2006
    ..The here described public releases, TRANSFAC 7.0 and TRANSCompel 7.0, are accessible under http://www.gene-regulation.com/pub/databases.html...
  60. pmc The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
    Malin E V Johansson
    Department of Medical Biochemistry, University of Gothenburg, 405 30 Gothenburg, Sweden
    Proc Natl Acad Sci U S A 105:15064-9. 2008
    ..These findings show that the Muc2 mucin can build a mucus barrier that separates bacteria from the colon epithelia and suggest that defects in this mucus can cause colon inflammation...
  61. ncbi Activity-dependent scaling of quantal amplitude in neocortical neurons
    G G Turrigiano
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254, USA
    Nature 391:892-6. 1998
    ....
  62. ncbi Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
    Axel Nimmerjahn
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Jahnstr 29, 69120 Heidelberg, Germany
    Nat Methods 1:31-7. 2004
    ..We expect SR101 staining to become a principal tool for investigating astroglia in vivo...
  63. pmc Human MicroRNA targets
    Bino John
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS Biol 2:e363. 2004
    ..microrna.org. Our analysis suggests that miRNA genes, which are about 1% of all human genes, regulate protein production for 10% or more of all human genes...
  64. ncbi Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
    A Bertolotti
    Skirball Institute of Biomolecular Medicine, Departments of Medicine and Cell Biology and the Kaplan Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    Nat Cell Biol 2:326-32. 2000
    ..These findings are consistent with a model in which BiP represses signalling through PERK and IRE1 and protein misfolding relieves this repression by effecting the release of BiP from the PERK and IRE1 lumenal domains...
  65. ncbi Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
    S C Bodine
    Regeneron Pharmaceuticals, Inc 777 Old Saw Mill River Road, Tarrytown, New York 10591 6707, USA
    Nat Cell Biol 3:1014-9. 2001
    ....
  66. ncbi Neuronal avalanches in neocortical circuits
    John M Beggs
    Unit of Neural Network Physiology, Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892 4075, USA
    J Neurosci 23:11167-77. 2003
    ..In the critical state, the network may satisfy the competing demands of information transmission and network stability...
  67. pmc Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132
    Dieter Edbauer
    The Picower Institute for Learning and Memory, Departments of Brain and Cognitive Sciences and Biology, Massachusetts Institute of Technology, Cambridge, MA 02319, USA
    Neuron 65:373-84. 2010
    ..Because NMDA receptor subunit composition profoundly affects synaptic plasticity, these observations have implications for the pathophysiology of fragile X syndrome, in which plasticity is altered...
  68. pmc A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis
    Ngan Vo
    Vollum Institute, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 102:16426-31. 2005
    ..These data reveal that a CREB-regulated miRNA regulates neuronal morphogenesis by responding to extrinsic trophic cues...
  69. ncbi Depression: a new animal model sensitive to antidepressant treatments
    R D Porsolt
    Nature 266:730-2. 1977
  70. ncbi Wnt signalling regulates adult hippocampal neurogenesis
    Dieter Chichung Lie
    Laboratory of Genetics, The Salk Institute, La Jolla, California 92037, USA
    Nature 437:1370-5. 2005
    ..Our data show that Wnt signalling is a principal regulator of adult hippocampal neurogenesis and provide evidence that Wnt proteins have a role in adult hippocampal function...
  71. pmc A mammalian microRNA expression atlas based on small RNA library sequencing
    Pablo Landgraf
    Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, Box 186, The Rockefeller University, New York, NY 10021, USA
    Cell 129:1401-14. 2007
    ..We also propose a subclassification scheme for miRNAs for assisting future experimental and computational functional analyses...
  72. doi Synaptic integration gradients in single cortical pyramidal cell dendrites
    Tiago Branco
    Wolfson Institute for Biomedical Research, University College London, London, UK
    Neuron 69:885-92. 2011
    ..Thus, single dendritic branches can already exhibit nonuniform synaptic integration, with the computational strategy shifting from temporal coding to rate coding along the dendrite...
  73. ncbi D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons
    C R Gerfen
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892
    Science 250:1429-32. 1990
    ..Severe movement disorders result from the loss of striatal dopamine in patients with Parkinson's disease. Rats with lesions of the nigrostriatal dopamine pathway caused by 6-hydroxydopamine (6-OHDA) serve as a model for ..
  74. ncbi Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    Joseph T Rodgers
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 434:113-8. 2005
    ..Thus, we have identified a molecular mechanism whereby SIRT1 functions in glucose homeostasis as a modulator of PGC-1alpha. These findings have strong implications for the basic pathways of energy homeostasis, diabetes and lifespan...
  75. ncbi Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
    L V Borovikova
    The Picower Institute for Medical Research, Manhasset, New York 11030, USA
    Nature 405:458-62. 2000
    ..Direct electrical stimulation of the peripheral vagus nerve in vivo during lethal endotoxaemia in rats inhibited TNF synthesis in liver, attenuated peak serum TNF amounts, and prevented the development of shock.
  76. ncbi The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
    C Rivera
    Department of Biosciences, University of Helsinki, Finland
    Nature 397:251-5. 1999
    ..These data support the conclusion that KCC2 is the main Cl- extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain...
  77. pmc Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
    Jill C Milne
    Sirtris Pharmaceuticals Inc, 790 Memorial Drive, Cambridge, Massachusetts 02139, USA
    Nature 450:712-6. 2007
    ..In Zucker fa/fa rats, hyperinsulinaemic-euglycaemic clamp studies demonstrate that SIRT1 activators improve whole-body glucose ..
  78. ncbi c-Myc-regulated microRNAs modulate E2F1 expression
    Kathryn A O'Donnell
    Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 435:839-43. 2005
    ....
  79. pmc Circulating mitochondrial DAMPs cause inflammatory responses to injury
    Qin Zhang
    Department of Surgery, Division of Trauma, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 464:104-7. 2010
    ..These signal through innate immune pathways identical to those activated in sepsis to create a sepsis-like state. The release of such mitochondrial 'enemies within' by cellular injury is a key link between trauma, inflammation and SIRS...
  80. pmc Combined sequence-based and genetic mapping analysis of complex traits in outbred rats
    Amelie Baud
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Nat Genet 45:767-75. 2013
    ..Here we report a combined sequence and genetic mapping analysis in outbred rats that maps 355 quantitative trait loci for 122 phenotypes...
  81. pmc Structural basis of long-term potentiation in single dendritic spines
    Masanori Matsuzaki
    Department of Cell Physiology, National Institute for Physiological Sciences and The Graduate University of Advanced Studies Sokendai, Myodaiji, Okazaki 444 8787, Japan
    Nature 429:761-6. 2004
    ..They further suggest that small spines are preferential sites for long-term potentiation induction, whereas large spines might represent physical traces of long-term memory...
  82. ncbi Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Am Soc Nephrol 14:2534-43. 2003
    ..The results indicate that NGAL may represent an early, sensitive, noninvasive urinary biomarker for ischemic and nephrotoxic renal injury...
  83. ncbi Microstructure of a spatial map in the entorhinal cortex
    Torkel Hafting
    Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Nature 436:801-6. 2005
    ..The map is anchored to external landmarks, but persists in their absence, suggesting that grid cells may be part of a generalized, path-integration-based map of the spatial environment...
  84. ncbi The role for endoplasmic reticulum stress in diabetes mellitus
    Decio L Eizirik
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808 CP 618, 1070 Brussels, Belgium
    Endocr Rev 29:42-61. 2008
    ..A better understanding of the pathways regulating ER stress in beta-cells may be instrumental for the design of novel therapies to prevent beta-cell loss in diabetes...
  85. ncbi Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    Umut Ozcan
    Department of Genetics and Complex Diseases, Harvard Medical School, Boston, MA 02115, USA
    Science 306:457-61. 2004
    ..Pharmacologic manipulation of this pathway may offer novel opportunities for treating these common diseases...
  86. pmc The microRNA.org resource: targets and expression
    Doron Betel
    Computational and Systems Biology Center, Memorial Sloan Kettering Cancer Center, NY, USA
    Nucleic Acids Res 36:D149-53. 2008
    ..The web resource provides users with functional information about the growing number of microRNAs and their interaction with target genes in many species and facilitates novel discoveries in microRNA gene regulation...
  87. ncbi Monocyte and macrophage heterogeneity
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 5:953-64. 2005
    ..These advances in our understanding have implications for the development of therapeutic strategies that are targeted to modify particular subpopulations of monocytes...
  88. pmc Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease
    Marius Wernig
    The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 105:5856-61. 2008
    ..Our results demonstrate the therapeutic potential of directly reprogrammed fibroblasts for neuronal cell replacement in the animal model...
  89. pmc A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis
    Gabriele Siegel
    Interdisziplinäres Zentrum für Neurowissenschaften, SFB488 Junior Group, Universitat Heidelberg, and Institut für Neuroanatomie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 345, 69120 Heidelberg, Germany
    Nat Cell Biol 11:705-16. 2009
    ..Our results uncover a previously unknown miRNA-dependent mechanism in neurons and demonstrate a previously unrecognized complexity of miRNA-dependent control of dendritic spine morphogenesis...
  90. pmc Long-term potentiation depends on release of D-serine from astrocytes
    Christian Henneberger
    UCL Institute of Neurology, University College London, London WC1N 3BG, UK
    Nature 463:232-6. 2010
    ..We therefore demonstrate that Ca(2+)-dependent release of D-serine from an astrocyte controls NMDAR-dependent plasticity in many thousands of excitatory synapses nearby...
  91. ncbi How to interpret LC3 immunoblotting
    Noboru Mizushima
    Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo, Japan
    Autophagy 3:542-5. 2007
    ..Accordingly, simple comparison of LC3-I and LC3-II, or summation of LC3-I and LC3-II for ratio determinations, may not be appropriate, and rather, the amount of LC3-II can be compared between samples...
  92. pmc Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties
    Tian Xia
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA
    ACS Nano 2:2121-34. 2008
    ....
  93. ncbi AMP-activated protein kinase in metabolic control and insulin signaling
    Mhairi C Towler
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
    Circ Res 100:328-41. 2007
    ..It is a key player in the development of new treatments for obesity, type 2 diabetes, and the metabolic syndrome...
  94. ncbi Inflammatory blockade restores adult hippocampal neurogenesis
    Michelle L Monje
    Stanford University, Department of Neurosurgery, MSLS P309, Mail Code 5487, 1201 Welch Road, Stanford, CA 94305 5487, USA
    Science 302:1760-5. 2003
    ....
  95. ncbi Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
    Stephen C Noctor
    Department of Neurology, Columbia University College of Physicians and Surgeons, 630 W 168th Street, New York, New York 10032, USA
    Nat Neurosci 7:136-44. 2004
    ..These findings provide a comprehensive and new view of the dynamics of cortical neurogenesis and migration...
  96. ncbi Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses
    Qiang Zhou
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Will Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Neuron 44:749-57. 2004
    ..Using two-photon time-lapse imaging of dendritic spines in acute hippocampal slices from neonatal rats, we found that the induction of long-term depression (LTD) by low-frequency stimulation is accompanied by a marked ..
  97. ncbi Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells
    A Yamamoto
    Department of Physiology and Liver Research Center Cell Biology, Kansai Medical University, Osaka, Japan
    Cell Struct Funct 23:33-42. 1998
    ..These results suggested that acidification of the lumenal space of autophagosomes or lysosomes by V-ATPase is important for the fusion between autophagosomes and lysosomes...
  98. ncbi Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
    T Nakagawa
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 403:98-103. 2000
    ..Thus, caspase-12 mediates an ER-specific apoptosis pathway and may contribute to amyloid-beta neurotoxicity...
  99. ncbi Identification of ubiquitin ligases required for skeletal muscle atrophy
    S C Bodine
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591 6707, USA
    Science 294:1704-8. 2001
    ..Overexpression of MAFbx in myotubes produced atrophy, whereas mice deficient in either MAFbx or MuRF1 were found to be resistant to atrophy. These proteins are potential drug targets for the treatment of muscle atrophy...
  100. pmc Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    Dongsheng Cai
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
    Nat Med 11:183-90. 2005
    ..These findings indicate that lipid accumulation in the liver leads to subacute hepatic 'inflammation' through NF-kappaB activation and downstream cytokine production. This causes insulin resistance both locally in liver and systemically...
  101. ncbi What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
    K C Berridge
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1109
    Brain Res Brain Res Rev 28:309-69. 1998
    ..In a study of the consequences of dopamine loss, rats were depleted of dopamine in the nucleus accumbens and neostriatum by up to 99% using 6-hydroxydopamine...

Research Grants76

  1. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..Mice (and rats) are particularly poor models for studying liver fibrosis and cirrhosis, common features of many human liver ..
  2. Xenoestrogen regulation of Leydig cells
    BENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010
    ..Male offspring will be analyzed for Leydig cell proliferation in prepubertal and pubertal rats. In addition, the number of Leydig cells will be enumerated by stereology in the adult testis at 90 days of age...
  3. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..Disease/therapy</keyword;keyword>Rats</keyword;keyword>Recovery of Function</keyword;keyword>Seizures/prevention &amp;control</keyword;..
  4. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
    ..Intravenous injection of this fraction causes proteinuria in rats. We have recently used state-of-the-art proteomics techniques to study the proteins in the active plasma fraction ..
  5. Pilot and definitive studies to evaluate Insertional Mutagenesis
    LU TAYLOR; Fiscal Year: 2012
    ..during FY 2006: RNA isolation for Toxicogenomic Variability Study: RNA is being isolated from sentinel Fischer 344 rats of varying ages from two different laboratories to determine the variability of Differential Gene Expression (DGE) ..
  6. Studies to Evaluate the Toxicological Potential of Test Articles
    LU TAYLOR; Fiscal Year: 2010
    ..during FY 2006: RNA isolation for Toxicogenomic Variability Study: RNA is being isolated from sentinel Fischer 344 rats of varying ages from two different laboratories to determine the variability of Differential Gene Expression (DGE) ..
  7. Noreen F Rossi; Fiscal Year: 2016
    ..assess whether exercise training will decrease arterial pressure and contralateral RSNA in 2K-1C (or sham-clipped) rats via inhibition of afferent nerve inputs from the clipped kidney;(2) We will evaluate whether exercise training ..
  8. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..circulation: a) 24 h food deprivation compared to ad libitum feeding and b) acute inflammation compared to healthy rats (peritoneal injection of gram-negative bacteriallipopolysaccharides at non-toxic doses)...
  9. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ..Increased Stat3 activity was observed in the lungs of IL-6-treated vs. placebo-treated T/HS rats;pharmacological inhibition of Stat3 using G-quartet oligodeoxynucleotide (GQ-ODN) T40214 developed by our group ..
  10. A Hybrid PARP Inhibitor and Redox Catalyst for Lung Transplantation
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..Prior to 90 min of unilateral lung ischemia and 4 h of reperfusion, rats will be treated with IV R-503, DHL, a monofunctional PARP inhibitor (INO-1001), or a combination of DHL and INO-..
  11. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..in Langendorff-perfused hearts following global I/R in adult and aged ovary-intact and gonadectomized female rats;respiration studies will be performed in isolated mitochondria...
  12. CRF-Oxytocin Interaction in the Regulation of Stress and Affect
    Joanna Dabrowska; Fiscal Year: 2013
    ..and how activation of CRFR2 and OTR in the BNST impact affective behavior in control and chronically stressed rats? Four analytical approaches will be used to directly address these questions: SA1) adenoviral-based neuronal ..
  13. Patrice G Guyenet; Fiscal Year: 2015
    ..of this grant, allows us to study the effects produced by selective activation of the C1 neurons in conscious rats in a time-controlled and artifact-free manner...
  14. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..Rat lungs are rendered ischemic in situ for 60 min and reperfused for 4 h. Prior to ischemia, rats are treated with IV R-503, DHL, the monofunctional PARP-1 inhibitor INO-1001, or a combination of DHL and INO-1001...
  15. Lung Lysyl Oxidase Regulation by Metal Ion Homeostasis
    Wande Li; Fiscal Year: 2013
    ..machineries as well as aberrant methylation of the LO gene promoter in emphysematous and carcinogenic lungs of rats receiving Cd by chronic administration...
  16. Bradley P Dixon; Fiscal Year: 2014
    ..bladder augmentations using stomach, small intestine, or colon tissue as well as sham operations in Sprague Dawley rats. At sequential time points following surgery, the animals will be sacrificed and the gastrointestinal and native ..
  17. Alan Frazer; Fiscal Year: 2016
    ..In our experiments, effects of SSRIs in female rats were examined...
  18. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..Aim #1: Establish the pharmacodynamic (PD) profile of R-801 in preventing tissue injury in a rodent model of CIN. Rats will be subjected to dehydration, prostaglandin synthetase inhibition, and an intravenous challenge of CM...
  19. Paul J Shami; Fiscal Year: 2014
    ..In Phase I, JSKT will accomplish 3 deliverables: 1) perform acute IV toxicology of JS-K in rats;2) perform bacterial mutagenicity (Ames) testing;and 3) draft the chemistry and manufacturing section for a JS-K ..
  20. Epigenetics of Sex Differences in Brain and Behavior
    BRIDGET NUGENT; Fiscal Year: 2012
    ..during the perinatal critical period will result in masculinized sex behavior in testosterone-primed adult female rats. Finally, under Specific Aim 3, our goal is to identify differentially regulated genetic targets of sex-specific ..
  21. Samuel D Crish; Fiscal Year: 2016
    ..of axonal transport in two rodent models of glaucoma - the DBA/2J mouse and the microbead occlusion model in rats. Specific aim 1 will examine changes in the cytoskeleton compared to two major risk factors in glaucoma: age (DBA/..
  22. Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNS
    Arnold E Postlethwaite; Fiscal Year: 2010
    ..We have basically adapted the Rechtschaffen-Bergmann disk over water (DOW) apparatus used to study sleep in rats to accommodate mice...
  23. Jian Li; Fiscal Year: 2016
    ..Scale-up of the active pharmaceutical ingredient to conduct range-finding toxicology studies in rats and non-rodent species, and ultimately IND-enabling GLP toxicology and safety pharmacology studies...
  24. SAMY LEWIZ HABIB; Fiscal Year: 2016
    ..Eker rats harboring mutations in TSC2 develop spontaneous renal tumors at a very high incidence...
  25. CHIH CHANG KEVIN WEI; Fiscal Year: 2014
    ..To define the role of mast cell chymase, we will treat mast cell deficient rats with ISF BK infusion or kallikrein infusion in the normal rat heart and in the rat heart subjected to VO with ACF...
  26. BONE MATRIX AND BONE RESORPTION
    Paul R Odgren; Fiscal Year: 2012
    ..We also showed that a PLEKHM1 frameshift mutation causes osteopetrosis in humans. Both ia rats and the human patient have TRAP+, non-resorbing osteoclasts with defective ruffled borders (RB) and defective ..
  27. Bi-functional Therapeutics for Allergy-BFTA
    Swey Shen Chen; Fiscal Year: 2010
    ..The mass unit will be tested in mice and escaladed in another species, rats and/or monkey. AIM 2...
  28. Haifei Shi; Fiscal Year: 2015
    ..The effect of BDNF on food intake and energy expenditure has never been thoroughly examined in female rats. Our preliminary data revealed gender-specific effects of central BDNF on food intake and energy expenditure...
  29. Sharon M Moe; Fiscal Year: 2014
    ..on the prevention and treatment of the bone and cardiovascular abnormalities of CKD-MBD by treating CKD and normal rats with zoledronic acid at early and late time points and determine the effect of serum measures of mineral ..
  30. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ..medicinal chemistry, high-resolution magnetic resonance imaging, and in vivo experimental models of stroke in rats and 12/15-lipoxygenase (LOX)-deficient mice...
  31. A Thioredoxin Mimetic for Radiocontrast Nephropathy
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..A sham injury group will be compared to treatment of CM-challenged rats with NAC or R-901 (over a one log dose range) initiated prior to CM administration under conditions of dehydration ..
  32. Subhash C Pandey; Fiscal Year: 2014
    ..via regulation of miRNAs or Arc- mediated regulation of dendritic spines in the CeA and MeA but not in BLA of rats. The proposed studies will provide novel information on the molecular mechanisms in the neurocircuitry of the ..
  33. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..Left lungs of Sprague Dawley (SD) rats are rendered ischemic in situ for 60 min and reperfused for 4 h...
  34. Adenosine and the Basal Forebrain in the Control of Behavioral State
    Robert E Strecker; Fiscal Year: 2012
    ..Similar CSR results in rats are described in Aim 1...
  35. Novel, Rapidly Translatable Technologies for Healing Long Bone Segmental Defects
    Christopher H Evans; Fiscal Year: 2010
    ..Critical size (5mm), segmental defects will be surgically created in the femora of athymic (nude) rats. These defects do not heal spontaneously. Because the animals are athymic, they will accept human xenografts...
  36. Lai Hua Xie; Fiscal Year: 2015
    ..DAD), and triggered activity (TA), and has been suggested as a potential proarrhythmic factor in rats, guinea pigs, and rabbits...
  37. Christie P Thomas; Fiscal Year: 2014
    ..DESCRIPTION (provided by applicant): Infusing an anti-VEGF antibody or a soluble VEGF receptor antagonist, sFlt1, in rats and mice lead to the development of severe proteinuria and hypertension accompanied by glomerular endotheliosis...
  38. Beverley Greenwood-Van Meerveld; Fiscal Year: 2016
    ..proposal has in her laboratory established a link between anxiety and visceral hypersensitivity by showing that rats predisposed to heightened levels of anxiety due to unpredictable early life stress exhibit a hypersensitive colon ..
  39. Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondria
    PETER J contact HAVEL; Fiscal Year: 2010
    ..We are proposing the following Specific Aims: 1: To test the hypothesis that IT surgery in pre-diabetic UCD-T2DM rats delays the onset of T2DM by influencing the production, secretion, and signaling of GI hormones (GLP-1, PYY, and ..
  40. A Bifunctional Katp Channel Activator and Redox Mimetic for BPD
    Kanneganti Murthy; Fiscal Year: 2013
    ..01). R-801 does not activate the sarcolemmal K+-ATP channel, as shown by its failure in rats to induce hypotension, hyperglycemia, or ventricular fibrillation...
  41. ROBERT MARK WIGHTMAN; Fiscal Year: 2016
    ..Measurements will be made in the freely moving rats during intracranial self-stimulation while monitoring oxygen and biogenic amine neurotransmitters. 4...
  42. Aquilur Rahman; Fiscal Year: 2014
    ..against herpes and pox viruses and drug-resistant variants in vivo at doses that are non-cytotoxic in mice, rats, guinea pigs and dogs, even at doses 1000-fold higher than the therapeutic dose...
  43. Aldosterone Action In The Brain, Hypertension and Inflammation
    ELISE PEERY GOMEZ-SANCHEZ; Fiscal Year: 2012
    ..Inhibition of MR in brains of Dahl Salt Sensitive hypertensive (SS) rats also mitigates their hypertension, though plasma aldo concentrations in this rat are low or normal...
  44. Prevention of Inherited Retinal Diseases by Therapeutic Rare Earth Nanoparticles
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2010
    ..super oxide dismutase by catalytically scavenging ROS and have been shown to prevent peroxide induced blindness in rats. We think of the nanoceria as being analogous to an aspirin for blindness in that they won't cure the primary ..
  45. JUSTIN RODNEY SAVAGE; Fiscal Year: 2015
    ..gingivalis-infected rats. Finally, and most importantly, it inhibits alveolar bone loss when administered parenterally in a diabetic P...
  46. Edward P Feener; Fiscal Year: 2016
    ..that activation of the kallikrein-kinin system (KKS) by intravitreal injection of carbonic anhydrase 1 (CA-I) in rats resulted in a rapid increase in retinal vascular permeability (RVP) followed by the development of focal areas of ..
  47. Tibor T Glant; Fiscal Year: 2014
    ..trait loci (QTLs) correlated with those identified in collagen-induced arthritis (CIA) in mice (mCia) and rats, colocalized with QTLs of other autoimmune models, and corresponded with human genomic regions identified in GWA ..
  48. Efficacy of GABAA a5 receptor inverse agonists in learning impaired rats
    EARL MICHAEL GIBBS; Fiscal Year: 2010
    ..Patients with learning disorders and those suffering from complications due to neurodegenerative diseases will greatly benefit as PWZ-029 moves another step closer to the clinic. ..
  49. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2013
    ..second involves reflex cardiovascular depression during mild gastric distension in ketamine-xylazine anesthetized rats, which appears to inhibit the prevagal neurons in the NA and presympathetic neurons in the rVLM through a GABAA ..
  50. Computer/Electrical Engineering
    Theodore Raphan; Fiscal Year: 2011
    ..6. Utilize software and hardware developed for humans to stimulate the vestibular nerves of rats and activate the vestibulo-sympathetic reflex. C...
  51. Subhash C Pandey; Fiscal Year: 2016
    ..Animal lines, such as selectively bred alcohol-preferring (P) and non-preferring (NP) rats, appear to be suitable models to study the molecular basis of the genetic predisposition to anxiety and alcoholism...
  52. A Novel Thioredoxin Mimetic Prodrug for Prevention of Bronchopulmonary Dysplasia
    Prakash Jagtap; Fiscal Year: 2013
    ..Aim #1: Define the pharmacokinetics (PK) of R-908 in newborn rats. We will define the plasma and tissue PK profile of R-908, and its metabolite R-901, in 2-day old rat pups...
  53. Alcohol-Induced Bone Resorption: The Role of Oxidative Stress
    Martin J J Ronis; Fiscal Year: 2013
    ..These data are consistent with previously published data from our laboratory in cycling female rats fed ethanol via total enteral nutrition...
  54. Mitochondrial and Nuclear Mechanisms of Estrogen Receptor-Mediated Cardioprotecti
    DONNA HOPE KORZICK; Fiscal Year: 2012
    ..following specific aims will be tested: 1) determine which ER subtype(s) reduce IT in aged, gonadectomized female rats, 2) determine the molecular mechanism(s) by which ERs alter ROS (ONOO- and O-2) through eNOS uncoupling, post-..
  55. DAVID MARSHALL GUIDOT; Fiscal Year: 2014
    ..alveolar epithelial cells and an established rat lung epithelial cell line in vitro, as well as HIV-1 transgenic rats with and without chronic alcohol ingestion in vivo...
  56. Novel SCID rat models for human cell transplantation studies
    Joseph C Ruiz; Fiscal Year: 2010
    ..Each of these defects is also observed in Ada KO rats. Studies in Ada KO mice have shown that low levels of ADA activity can rescue the liver dysfunction, as well as ..
  57. Molecular Mechanisms of Chemoprevention: NRF2 Signaling
    Thomas W Kensler; Fiscal Year: 2013
    ..for the first time a comprehensive mass balance for the fate of the ultimate carcinogen, exo-aflatoxin-epoxide, in rats. The predictive value of these biomarkers for individual risk of liver cancer will be assessed...
  58. Novel Means to Establish Free Radical Balance in the Neonatal Premature Lung
    Prakash Jagtap; Fiscal Year: 2011
    ..R-100 has no effect on systemic blood pressure in normotensive control rats nor in monocrotaline-induced PAH in rats, but is effective as a selective pulmonary vasodilator in 3 distinct ovine ..
  59. Impaired mitochondrial fusion in pulmonary arterial hypertension
    Stephen L Archer; Fiscal Year: 2010
    ..Impaired fusion and normoxic HIF-1a activation are found in humans with PAH and fawn-hooded rats (FHR), a strain that spontaneously develops PAH...
  60. Karen Block; Fiscal Year: 2015
    ..when cultured renal cells are exposed to high glucose (HG) or AGEs as well as in the renal cortex and glomeruli of rats with type 1 diabetes...
  61. Iman Hassan; Fiscal Year: 2014
    ..The hypothesis is based on our preliminary data that show that: 1) TCE exposure of pregnant rats significantly decreased fetal weight and induced focal areas of necrosis within the basal zone of the placenta;and ..
  62. LIVER PRESERVATION FOR TRANSPLANTATION
    John J Lemasters; Fiscal Year: 2012
    ..parameter- indicating fluorophores inside individual hepatocytes and their organelles in liver grafts of living rats and mice...
  63. Barry E Levin; Fiscal Year: 2015
    ..We have selectively bred rats which rapidly develop diet-induced obesity (DIO) when the caloric density of their diets is increased...
  64. KALLIKREIN KININ SYSTEM IN INFLAMMATORY BOWEL DISEASE
    Robert Colman; Fiscal Year: 2001
    ..produce chronic granulomatous inflammation similar to Crohn's disease (regional ileitis) in genetically susceptible rats as well as associated systemic inflammation...
  65. Restoration of Estradiol Effects on Learning by Cholinergic Enhancement
    Robert Gibbs; Fiscal Year: 2009
    ..provide proof of principle that estradiol-mediated enhancement of cognitive function can be restored (a) in young rats with cholinergic lesions, and (b) in aged rats that have undergone long-term loss of ovarian function, by treating ..
  66. Innate Immunity in Experimental Arthritis of Kininogen
    Robert Colman; Fiscal Year: 2007
    ..inflammatory arthritis is associated with in vivo activation of the kallikrein-kinln system (KKS) in Lewis rats and is selectively inactivated in these susceptible Lewis rats, but not in resistant Buffalo rats...
  67. Sleep in Rats: From Conceptualization to Measurement, Analysis and Interpretation
    Gayle Giboney Page; Fiscal Year: 2010
    ..My dissertation and early career research studies in rats show that adequate provision of perioperative analgesia statistically and biologically significantly attenuate the ..
  68. Imbalances in Calcium Homeostasis: Mechanism Behind Ethanol-Related Dendritic Deg
    Cynthia A Dlugos; Fiscal Year: 2010
    ..This is a major health concern as the aging population continues to escalate. In aging rats, chronic ethanol consumption results in regression of Purkinje neuron (PN) dendrites, a process that surely alters ..
  69. NEUROTRANSMITTERS AND VENTILATORY CONTROL
    EARL OLSON; Fiscal Year: 1990
    ..Unanesthetized, unrestrained rats prepared with chronically indwelling femoral artery catheters will be used to obtain arterial blood gas and acid-..
  70. ENVIRONMENTAL AND PHARMACOLOGICAL CONTROL OF DRUG ABUSE
    Marilyn Carroll; Fiscal Year: 2000
    ..g., acquisition, drug-rewarded behavior, abstinence, "craving" and "relapse"). In the first experiment groups of rats will be trained to self-administer cocaine using an autoshaping procedure to obtain a quantitative measure of the ..
  71. Neurobehavioral effects of adolescent GHB
    Ratna Sircar; Fiscal Year: 2007
    ..Compared to adult rats, adolescent rats have been shown to be less sensitive to the sedative and motor impairing effects of ethanol...
  72. Effects of Acupuncture-Induced nNOS-NO in Dorsal Medulla on Sensory Neuropathy
    Sheng Xing Ma; Fiscal Year: 2010
    ..latencies of heat and cold stimuli to the hind foot are consistently decreased in Zucker diabetic Fatty (ZDF) rats. Hyperalgesia and hypersensitivity to temperature/ pressure in ZDF rats are improved by low-frequency ..
  73. The Effects of Vitamin B3 on Traumatic Brain Injury
    MICHAEL HOANE; Fiscal Year: 2009
    ..However, when B3 was investigated in middle-aged (14 month old) rats following CCI, we found that the preclinical effectiveness observed in the young rats did not occur in the middle-..
  74. MINORITY SCHOOL FACULTY DEVELOPMENT AWARD
    HALCYON WATKINS; Fiscal Year: 1992
    ..quinpirole) agonists on the development of hypertension and urinary sodium excretion in genetic hypertensive rats on different levels of dietary sodium intake...