neurologic mutants mice

Summary

Summary: Mice which carry mutant genes for neurologic defects or abnormalities.

Top Publications

  1. ncbi Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene
    J Zuo
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    Nature 388:769-73. 1997
  2. ncbi Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathway
    Sanyong Niu
    The Cain Foundation Laboratories, Houston, TX 77030, USA
    Neuron 41:71-84. 2004
  3. ncbi Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards
    Susana Pecina
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1109, USA
    J Neurosci 23:9395-402. 2003
  4. ncbi A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
    G D'ARCANGELO
    Roche Institute of Molecular Biology, Hoffman La Roche, Nutley, New Jersey 07110, USA
    Nature 374:719-23. 1995
  5. pmc Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis
    A Bosio
    Institute of Biochemistry I, Medical Faculty, University of Cologne, Germany
    Proc Natl Acad Sci U S A 93:13280-5. 1996
  6. ncbi Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon
    S Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 21:7568-75. 2001
  7. ncbi Spatiotemporal progression of neurodegeneration and glia activation in the wobbler neuropathy of the mouse
    S Rathke-Hartlieb
    Developmental Biology and Molecular Pathology, University of Bielefeld, Germany
    Neuroreport 10:3411-6. 1999
  8. ncbi Axonal swellings and degeneration in mice lacking the major proteolipid of myelin
    I Griffiths
    Applied Neurobiology Group, Department of Veterinary Clinical Studies, University of Glasgow, Glasgow G61 1QH, Scotland, UK
    Science 280:1610-3. 1998
  9. ncbi Multiple functions of the myelin-associated glycoprotein MAG (siglec-4a) in formation and maintenance of myelin
    M Schachner
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Hamburg, Germany
    Glia 29:154-65. 2000
  10. ncbi Role of the reelin signaling pathway in central nervous system development
    D S Rice
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Annu Rev Neurosci 24:1005-39. 2001

Research Grants

  1. Beclin 1 Neurodegeneration and Alzheimer's Disease
    Tony Wyss-Coray; Fiscal Year: 2013
  2. EXPRESSION OF GRANULE CELL GABA RECEPTORS
    Adrienne Frostholm; Fiscal Year: 1993
  3. ROLE OF REELIN IN CONTROL OF CELL MIGRATION IN BRAIN
    Tom Curran; Fiscal Year: 2000
  4. JAX Neurogenetics Conference
    WAYNE FRANKEL; Fiscal Year: 2004
  5. Function of Reelin in cortical development
    GABRIELLA D ARCANGELO; Fiscal Year: 2007
  6. THIRD WORKSHOP IN MOUSE MOLECULAR NEUROGENETICS
    WAYNE FRANKEL; Fiscal Year: 1999
  7. Opiate Addiction and HIV-1 Induced Release of Cytokines
    William Banks; Fiscal Year: 2006
  8. Mechanisms of HIV Transport Across the BBB
    William Banks; Fiscal Year: 2004
  9. PTS1 Regulation of Brain Met Enk Levels in Alcoholism
    William Banks; Fiscal Year: 2004
  10. Prion Transport Across the Blood-Brain Barrier
    William Banks; Fiscal Year: 2009

Detail Information

Publications193 found, 100 shown here

  1. ncbi Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene
    J Zuo
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    Nature 388:769-73. 1997
    ..Thus the activation of apoptotic neuronal death in Lurcher mice may provide a physiologically relevant model for excitotoxic cell death...
  2. ncbi Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathway
    Sanyong Niu
    The Cain Foundation Laboratories, Houston, TX 77030, USA
    Neuron 41:71-84. 2004
    ..Thus, the same signaling pathway controls both neuronal migration and dendrite maturation...
  3. ncbi Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards
    Susana Pecina
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1109, USA
    J Neurosci 23:9395-402. 2003
    ....
  4. ncbi A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
    G D'ARCANGELO
    Roche Institute of Molecular Biology, Hoffman La Roche, Nutley, New Jersey 07110, USA
    Nature 374:719-23. 1995
    ..The encoded protein resembles extracellular matrix proteins involved in cell adhesion. The reeler phenotype thus seems to reflect a failure of early events associated with brain lamination which are normally controlled by reelin...
  5. pmc Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis
    A Bosio
    Institute of Biochemistry I, Medical Faculty, University of Cologne, Germany
    Proc Natl Acad Sci U S A 93:13280-5. 1996
    ..GalC and sGalC are essential for the unperturbed lipid bilayer of the myelin membrane of CNS and PNS. The severe dysmyelinosis leads to death of the cgt-/- mouse at the end of the myelination period...
  6. ncbi Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon
    S Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 21:7568-75. 2001
    ....
  7. ncbi Spatiotemporal progression of neurodegeneration and glia activation in the wobbler neuropathy of the mouse
    S Rathke-Hartlieb
    Developmental Biology and Molecular Pathology, University of Bielefeld, Germany
    Neuroreport 10:3411-6. 1999
    ..Microgliosis occurs only from 23 d.p.n. onward. Our data demonstrate that in the WR disease, neurodegeneration in thalamus, cerebellum, and brain stem precedes motoneuron degeneration, astrogliosis and microgliosis...
  8. ncbi Axonal swellings and degeneration in mice lacking the major proteolipid of myelin
    I Griffiths
    Applied Neurobiology Group, Department of Veterinary Clinical Studies, University of Glasgow, Glasgow G61 1QH, Scotland, UK
    Science 280:1610-3. 1998
    ..Thus, fiber degeneration, which was probably secondary to impaired axonal transport, could indicate that myelinated axons require local oligodendroglial support...
  9. ncbi Multiple functions of the myelin-associated glycoprotein MAG (siglec-4a) in formation and maintenance of myelin
    M Schachner
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Hamburg, Germany
    Glia 29:154-65. 2000
    ..These observations suggest that other molecules performing similar functions as MAG might compensate, at least partially, for the absence of MAG in the null mutant...
  10. ncbi Role of the reelin signaling pathway in central nervous system development
    D S Rice
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Annu Rev Neurosci 24:1005-39. 2001
    ..Recent studies have also suggested a role for the Reelin pathway in axonal branching, synaptogenesis, and pathology underlying neurodegeneration...
  11. ncbi Lurcher mice exhibit potentiation of GABA(A)-receptor-mediated conductance in cerebellar nuclei neurons in close temporal relationship to Purkinje cell death
    C Linnemann
    Department of Cognitive Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, 72076 Tubingen, Germany
    J Neurophysiol 91:1102-7. 2004
    ..The changes in g(syn), suitable to increase the efficacy of GABAergic transmission, occur in close temporal relationship to PC death and, thus, may reflect a functional adaptation to the loss of the DCN's main GABAergic afferents...
  12. ncbi Interaction of granule, Purkinje and inferior olivary neurons in lurcher chimaeric mice. I. Qualitative studies
    R Wetts
    J Embryol Exp Morphol 68:87-98. 1982
    ..Beta-glucuronidase is not an accurate cell marker for granule cells, and so no conclusion concerning the action of the Lc gene on granule cells could be made with these chimaeras...
  13. ncbi Motor abnormalities in lurcher mutant mice
    R Lalonde
    Hotel Dieu Hospital, Neurology Service, Montreal, Canada
    Physiol Behav 51:523-5. 1992
    ..There was no decrease in rearing responses. These results indicate that in spite of cerebellar degeneration and ataxia, lurcher mutants are not impaired in all tests measuring motor function...
  14. ncbi Early development of the Lurcher cerebellum: Purkinje cell alterations and impairment of synaptogenesis
    N Dumesnil-Bousez
    INSERM U 106 Hôpital de la Salpétrière, Paris, France
    J Neurocytol 21:506-29. 1992
    ..The hypoplasia of the external granular layer and the altered synaptic investment of the Purkinje cell after P10 are considered to be consequences of the early Purkinje cell defect...
  15. ncbi Motor learning in lurcher mutant mice
    R Lalonde
    Hotel Dieu Hospital, Neurology Service, Montreal, Que, Canada
    Brain Res 639:351-3. 1994
    ..In a test where motor deficits occurred, rapid improvement was seen. Thus, in spite of massive cerebellar degeneration, there was no evidence of a decreased rate in motor learning...
  16. ncbi Differential roles of cerebellar cortex and deep cerebellar nuclei in the learning of the equilibrium behavior: studies in intact and cerebellectomized lurcher mutant mice
    J Caston
    Laboratoire de Neurophysiologie Sensorielle, Faculte des Sciences, Universite de Rouen, Mont Saint Aignan, France
    Brain Res Dev Brain Res 86:311-6. 1995
    ..Therefore, it can be concluded that the adaptive motor capabilities of lurcher mice are less developed than those of control animals...
  17. ncbi The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice
    Weiqian Mi
    ZMMK and Institute for Genetics, University of Cologne, Cologne, Germany
    Brain 128:405-16. 2005
    ..We conclude that axon degeneration mechanisms are more closely related than previously thought and that a link exists in gad between spheroid pathology and Wallerian degeneration that could hold for other disorders...
  18. ncbi A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration
    Kei Watase
    Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 34:905-19. 2002
    ..It appears that those neurons that cannot sequester the mutant protein efficiently and thereby curb its toxicity suffer the worst damage from polyglutamine-induced toxicity...
  19. ncbi Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality
    T Chae
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 18:29-42. 1997
    ..The phenotype of p35 mutant mice thus demonstrates that the formation of cortical laminar structure depends on the action of the p35/cdk5 kinase...
  20. ncbi Absence of Fyn and Src causes a reeler-like phenotype
    Gloria Kuo
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Neurosci 25:8578-86. 2005
    ..This implies that Src and Fyn are needed for Reelin-dependent events during brain development...
  21. pmc Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea
    Waheeda A Hossain
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurosci 25:6857-68. 2005
    ....
  22. ncbi Patterned Purkinje cell degeneration in mouse models of Niemann-Pick type C disease
    Justyna R Sarna
    Department of Cell Biology and Anatomy, and Genes and Development Research Group, Faculty of Medicine, The University of Calgary, Alberta T2N 4N1, Canada
    J Comp Neurol 456:279-91. 2003
    ..The pattern of cell death thus reflects the fundamental compartmentation of the cerebellum into zones and stripes...
  23. ncbi Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: effect of the Lp mutation
    Elena Torban
    Department of Biochemistry, McGill University, 3655 Drummond, Room 907, Montreal, QC, Canada H3G 1Y6
    Gene Expr Patterns 7:346-54. 2007
    ....
  24. ncbi Neuronal position in the developing brain is regulated by mouse disabled-1
    B W Howell
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nature 389:733-7. 1997
    ..Because mDab1 is expressed in wild-type cortical neurons, and Reelin expression is normal in mdab1 mutants, mDab1 may be part of a Reelin-regulated or parallel pathway that controls the final positioning of neurons...
  25. ncbi A CaV2.1 calcium channel mutation rocker reduces the number of postsynaptic AMPA receptors in parallel fiber-Purkinje cell synapses
    Takashi Kodama
    Department of Information Physiology, National Institute for Physiological Sciences, Okazaki 444 8787, Japan
    Eur J Neurosci 24:2993-3007. 2006
    ..These lines of evidence suggest that even a moderate dysfunction of CaV2.1 Ca2+ channel can cause substantial changes in postsynaptic molecular composition of the PF-PC synapses and dendritic structure of PCs...
  26. ncbi Quantitative morphological analysis of the cerebellar nuclei in normal and lurcher mutant mice. I. Morphology and cell number
    J A Heckroth
    Indiana University School of Medicine, Terre Haute Center for Medical Education at Indiana State University 47809
    J Comp Neurol 343:173-82. 1994
    ....
  27. ncbi Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice
    M Sheldon
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 389:730-3. 1997
    ..The similar phenotypes of reeler, scrambler, yotari and mdab1 null mice indicate that Reelin and mDab1 function as signalling molecules that regulate cell positioning in the developing brain...
  28. ncbi A cerebellar abnormality in the mouse with motor end-plate disease
    D J Dick
    Neuropathol Appl Neurobiol 11:141-7. 1985
    ..Axonal spheroids may be seen on cerebellar Purkinje cell axons in the med mouse, and the character of extra-cellular recordings obtained from the Purkinje cells is abnormal...
  29. ncbi Disruption of the nuclear hormone receptor RORalpha in staggerer mice
    B A Hamilton
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nature 379:736-9. 1996
    ..We propose a model based on these results, in which RORalpha interacts with the thyroid hormone signalling pathway to induce Purkinje-cell maturation...
  30. ncbi Interaction of granule, Purkinje and inferior olivary neurons in lurcher chimeric mice. II. Granule cell death
    R Wetts
    Brain Res 250:358-62. 1982
    ..Thus the granule cell death is an indirect consequence of the lurcher gene acting on some other cell type, probably the cerebellar Purkinje cells...
  31. ncbi Dystonin expression in the developing nervous system predominates in the neurons that degenerate in dystonia musculorum mutant mice
    G Bernier
    Institut du Cancer de Montreal, Centre de Recherche L C Simard, Quebec, Canada
    Mol Cell Neurosci 6:509-20. 1995
    ..We also detect dystonin expression in motor neurons most of which are unaffected by the degenerative process in dt mice...
  32. ncbi A genetic basis for obsessive grooming
    Ann M Graybiel
    Department of Brain and Cognitive Sciences and the McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 33:1-2. 2002
    ..These Hoxb8 mutants will be valuable in exploring the genetics and pathophysiology of OC-spectrum disorders as well as strategies for their treatment...
  33. ncbi Effects of galactolipid elimination on oligodendrocyte development and myelination
    J Marcus
    Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599 7250, USA
    Glia 30:319-28. 2000
    ..The data suggest that galactolipids play an important developmental role in regulating the maturation program and final number of oligodendrocytes...
  34. ncbi Quantitative organization of neurotransmitters in the deep cerebellar nuclei of the Lurcher mutant
    Fahad Sultan
    Department of Cognitive Neurology, 72076 Tubingen, Germany
    J Comp Neurol 452:311-23. 2002
    ....
  35. ncbi A null mutation in VAMP1/synaptobrevin is associated with neurological defects and prewean mortality in the lethal-wasting mouse mutant
    Arne M Nystuen
    Department of Genetics, Cell Biology and Anatomy, 6008 Durham Research Center, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Neurogenetics 8:1-10. 2007
    ..Taken together, these data indicate that VAMP1 has a vital role in a subset of central nervous system tissues...
  36. ncbi An increased expression of Ca(2+) channel alpha(1A) subunit immunoreactivity in deep cerebellar neurons of rolling mouse Nagoya
    K Sawada
    Department of Anatomy, University of Tokushima School of Medicine, Tokushima 770 8503, Japan
    Neurosci Lett 316:87-90. 2001
    ..Increased expression of the alpha(1A) subunit in deep cerebellar neurons might compensate for the altered function of the P/Q-type Ca(2+) channel of RMN...
  37. ncbi Multiple dose-dependent effects of Lis1 on cerebral cortical development
    Michael J Gambello
    Department of Pediatrics and Medicine, University of California, San Diego, La Jolla, California 92093 0627, USA
    J Neurosci 23:1719-29. 2003
    ..These studies reveal the importance of LIS1 levels in orderly cerebral cortical morphogenesis and suggest new insights into the pathogenesis of type I lissencephaly...
  38. ncbi Sensorimotor learning and retention during equilibrium tests in Purkinje cell degeneration mutant mice
    N Le Marec
    Unit of Behavioral Neurology, Neurobiology, and Neuropsychology, Hôtel Dieu Hospital Research Center, Montreal, Canada
    Brain Res 768:310-6. 1997
    ..The cerebellar cortex is critically involved in timing whole body movements during postural adjustments to a mobile beam but not to four types of immobile apparatus...
  39. ncbi Wobbler, a mutation affecting motoneuron survival and gonadal functions in the mouse, maps to proximal chromosome 11
    K Kaupmann
    Developmental Biology Unit, University of Bielefeld, Germany
    Genomics 13:39-43. 1992
    ..Closely linked markers like Erbb provide tools for a prognostic DNA diagnosis of the wobbler disease, and thereby for its analysis by descriptive and experimental embryology...
  40. ncbi Apoptotic cell death of cerebellar granule cells in rolling mouse Nagoya
    Young Suk Suh
    Department of Anatomy, College of Medicine and Human Genetics, Institute of Medicine Science Research Center, Korea University, 126 1 Anam dong 5 ga, Sungbuk Ku, Seoul 136 705, South Korea
    Neurosci Lett 325:1-4. 2002
    ..Condensation and fragmentation of granule cell nuclei in rolling mouse were observed frequently. These results suggest that apoptosis is one of the mechanisms of granule cell loss in the rolling cerebellum...
  41. ncbi A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice
    A Nystuen
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Neuron 32:203-12. 2001
    ..Although other mutations in phosphoinositide enzymes are associated with synaptic defects without neuronal loss, weeble shows that Inpp4a is critical for the survival of a subset of neurons during postnatal development in mice...
  42. ncbi Altered calcium channel currents in Purkinje cells of the neurological mutant mouse leaner
    N M Lorenzon
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurosci 18:4482-9. 1998
    ..Thus, the leaner mutation selectively reduces P-type currents in Purkinje cells, and the alpha1A subunit and P-type current appear to be essential for normal cerebellar function...
  43. ncbi Three ENU-induced neurological mutations in the pore loop of sodium channel Scn8a (Na(v)1.6) and a genetically linked retinal mutation, rd13
    David A Buchner
    Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618, USA
    Mamm Genome 15:344-51. 2004
    ..The new alleles of Scn8a will be valuable for analysis of sodium channel physiology and disease...
  44. ncbi Insights from mouse models of absence epilepsy into Ca2+ channel physiology and disease etiology
    Ricardo Felix
    Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies of the National Polytechnic Institute, CINVESTAV IPN, Mexico DF
    Cell Mol Neurobiol 22:103-20. 2002
    ..3. The discovery and systematic analysis of these animal models is helping to clarify how different mutations affect channel function and how altered channel function produces disease...
  45. ncbi Hoxb8 is required for normal grooming behavior in mice
    Joy M Greer
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Neuron 33:23-34. 2002
    ..The aberrant behavior observed in Hoxb8 mutants is not unlike that of humans suffering from the OC-spectrum disorder, trichotillomania. Interestingly, Hoxb8 is expressed in regions of the CNS known as the "OCD-circuit."..
  46. ncbi Calcium channels and channelopathies of the central nervous system
    Daniela Pietrobon
    Dept of Biomedical Sciences, Univ of Padova, Italy
    Mol Neurobiol 25:31-50. 2002
    ....
  47. ncbi Bidirectional alterations in cerebellar synaptic transmission of tottering and rolling Ca2+ channel mutant mice
    Kaori Matsushita
    Department of Information Physiology, Center for Brain Experiment, National Institute for Physiological Sciences, Okazaki National Research Institutes, Okazaki 444 8585, Japan
    J Neurosci 22:4388-98. 2002
    ....
  48. ncbi Rocker is a new variant of the voltage-dependent calcium channel gene Cacna1a
    T A Zwingman
    Department of Neuroscience, University Alzheimer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 21:1169-78. 2001
    ..Overall these findings point to an important dissociation between the seizure phenotypes and the abnormalities in catecholamine metabolism, and they emphasize the value of allelic series in the study of gene function...
  49. ncbi The Wlds mutation delays robust loss of motor and sensory axons in a genetic model for myelin-related axonopathy
    Mohtashem Samsam
    Department of Neurology, University of Wurzburg, D 97080 Wurzburg, Germany
    J Neurosci 23:2833-9. 2003
    ..We conclude that myelin-related axonal loss is a process having some features in common with Wallerian degeneration. Introducing the Wld(s) gene would be a promising approach to delaying detrimental axonal loss in myelin disorders...
  50. ncbi Abnormal expression of tyrosine hydroxylase immunoreactivity in cerebellar cortex of ataxic mutant mice
    K Sawada
    Department of Anatomy, School of Medicine, Tokushima University, Tokushima 770 8503, Japan
    Brain Res 829:107-12. 1999
    ..Since TH promoter is activated by Ca2+, TH expression in the mutant Purkinje cells may predict neuronal dysfunction caused by alterations in cellular Ca2+ currents...
  51. ncbi Morphologic investigation of rolling mouse Nagoya (tg(rol)/tg(rol)) cerebellar Purkinje cells: an ataxic mutant, revisited
    I J Rhyu
    Institute of Human Genetics and Department of Anatomy, Korea University College of Medicine, Seoul, South Korea
    Neurosci Lett 266:49-52. 1999
    ..The correlation between the presence of altered Purkinje cell synapses and ataxia in rolling mice warrants further investigation...
  52. ncbi L-type calcium channels contribute to the tottering mouse dystonic episodes
    D B Campbell
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Mol Pharmacol 55:23-31. 1999
    ..The susceptibility of L-type calcium channels to voltage-dependent facilitation may promote this abnormal motor phenotype...
  53. ncbi Over-expression of corticotropin-releasing factor mRNA in inferior olivary neurons of rolling mouse Nagoya
    Kazuhiko Sawada
    Department of Anatomy and Developmental Neurobiology, University of Tokushima School of Medicine, Tokushima 770 8503, Japan
    Brain Res Mol Brain Res 117:190-5. 2003
    ..These results suggest a region-related over-expression of CRF mRNA in the ION of RMN. This may be responsible for the increased sensitivity of some Purkinje cells to glutamate, resulting in ataxic symptoms of RMN...
  54. ncbi Abnormal transmitter release at neuromuscular junctions of mice carrying the tottering alpha(1A) Ca(2+) channel mutation
    J J Plomp
    Department of Physiology, Leiden University Medical Centre, Leiden, The Netherlands
    Brain 123:463-71. 2000
    ..This study shows that functional consequences of alpha(1A) mutations causing cerebral disorders can be characterized at the NMJ...
  55. ncbi Reduced voltage sensitivity of activation of P/Q-type Ca2+ channels is associated with the ataxic mouse mutation rolling Nagoya (tg(rol))
    Y Mori
    Department of Information Physiology, National Institute for Physiological Sciences, The Graduate University for Advanced Studies, Okazaki, Aichi, Japan
    J Neurosci 20:5654-62. 2000
    ....
  56. ncbi Whole-cell and single-channel analysis of P-type calcium currents in cerebellar Purkinje cells of leaner mutant mice
    L S Dove
    Department of Medical Pharmacology and Toxicology, College of Medicine, Texas A and M University Health Science Center, College Station, Texas 77843 1114, USA
    J Neurosci 18:7687-99. 1998
    ..These results suggest that the tgla mutation can alter native P-type calcium channels at the single-channel level and that these alterations may contribute to the neuropathology of the leaner phenotype...
  57. ncbi Interaction of reelin signaling and Lis1 in brain development
    Amir H Assadi
    Cain Foundation Laboratories and Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 35:270-6. 2003
    ..Dab1 and Lis1 bound in a reelin-induced phosphorylation-dependent manner. These data indicate genetic and biochemical interaction between the reelin signaling pathway and Lis1...
  58. ncbi Neurological abnormalities in a knock-in mouse model of Huntington's disease
    C H Lin
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hum Mol Genet 10:137-44. 2001
    ..These mice will serve as useful reagents in experiments designed to reveal the molecular nature of neuronal dysfunction underlying HD...
  59. ncbi mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw)
    K Noben-Trauth
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 44:266-72. 1997
    ..Our results reveal an epistatic relationship between the mdfw and the dfw genes and provide a model system to study nonsyndromic hearing loss in mice...
  60. ncbi Striatal dysfunction in Rolling mouse Nagoya: an electrophysiological study
    H Tomoda
    Department of Clinical Neurophysiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    J Neurol Sci 112:106-12. 1992
    ..These results are in agreement with our previously reported findings of increased glucose metabolism and reduced concentration of GABA in the GP and substantia nigra pars reticula (SNr) in rolling.(ABSTRACT TRUNCATED AT 250 WORDS)..
  61. ncbi Taltirelin improves motor ataxia independently of monoamine levels in rolling mouse nagoya, a model of spinocerebellar atrophy
    Tomoka Nakamura
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    Biol Pharm Bull 28:2244-7. 2005
    ....
  62. ncbi Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia
    Joy T Walter
    Department of Neuroscience, Albert Einstein College of Medicine, 506 Kennedy Center, 1410 Pelham Parkway South, Bronx, New York 10461, USA
    Nat Neurosci 9:389-97. 2006
    ..Our data support the hypothesis that the precision of intrinsic pacemaking in Purkinje cells is essential for motor coordination and suggest that K(Ca) channels may constitute a potential therapeutic target in EA2...
  63. ncbi Neurological mouse mutants and the genes of myelin
    K A Nave
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Germany
    J Neurosci Res 38:607-12. 1994
    ..They also illustrate some of the problems encountered in defining protein functions from complex mutant phenotypes...
  64. ncbi Purkinje cell death: differences between developmental cell death and neurodegenerative death in mutant mice
    Isabelle Dusart
    Universite Pierre et Marie Curie Paris 6, Paris, France
    Cerebellum 5:163-73. 2006
    ....
  65. ncbi Purkinje cell compartments in the reeler mutant mouse as revealed by Zebrin II and 90-acetylated glycolipid antigen expression
    M A Edwards
    Department of Biomedical Sciences, E K Shriver Center, Waltham, MA 02254
    Anat Embryol (Berl) 190:417-28. 1994
    ....
  66. ncbi A missense mutation in the sodium channel Scn8a is responsible for cerebellar ataxia in the mouse mutant jolting
    D C Kohrman
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109, USA
    J Neurosci 16:5993-9. 1996
    ..A shift in the threshold of the Scn8a channel could account for the reduced spontaneous activity of Purkinje cells, reduced inhibitory output from the cerebellum, and loss of motor control observed in jolting mice...
  67. ncbi Prolonged axonal survival in transected nerves of C57BL/Ola mice is independent of age
    T O Crawford
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Neurocytol 24:333-40. 1995
    ..The persistence of axoplasm after nerve injury in C57BL/Ola mice may be the feature most closely related to the function of the mutant gene...
  68. ncbi The reeler gene encodes a protein with an EGF-like motif expressed by pioneer neurons
    S Hirotsune
    Genome Science Laboratory, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Nat Genet 10:77-83. 1995
    ..Our findings offer an explanation for how the reeler mutant phenotype causes a disturbance of the complex architecture of the neuronal network...
  69. ncbi Insertional mutation of the motor endplate disease (med) locus on mouse chromosome 15
    D C Kohrman
    Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618, USA
    Genomics 26:171-7. 1995
    ..The transgene-induced allele provides molecular access to the med gene, whose function is required for synaptic transmission at the neuromuscular junction and long-term survival of cerebellar Purkinje cells...
  70. ncbi Characterization of acetylcholine release and the compensatory contribution of non-Ca(v)2.1 channels at motor nerve terminals of leaner Ca(v)2.1-mutant mice
    S Kaja
    Department of Neurology, Leiden University Medical Centre, P O Box 9600, 2300 RC Leiden, The Netherlands
    Neuroscience 144:1278-87. 2007
    ..2 channels, and hampers that of Ca(v)2.3 channels. This is the first report directly showing at single synapses the deficits and plasticity in transmitter release resulting from the Ln mutation of Cacna1a...
  71. ncbi Neurotransmitter abnormality in Rolling mouse Nagoya, an ataxic mutant mouse
    O Muramoto
    Brain Res 215:295-304. 1981
    ....
  72. ncbi Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya
    K Sawada
    Department of Anatomy and Developmental Neurobiology, University of Tokushima Graduate School Institute of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Neuroscience 152:609-17. 2008
    ..Such expressional changes in ryanodine receptor subtypes may be involved in Ca(2+) channel alpha(1A) subunit gene mutation, and may alter regulation of intracellular Ca(2+) concentrations in cerebellar cortical neurons...
  73. pmc Anti-ataxic effects of TRH and its analogue, TA-0910, in Rolling mouse Nagoya by metabolic normalization of the ventral tegmental area
    K Kinoshita
    Pharmaceutical Development Research Laboratory, Tanabe Seiyaku Co, Ltd, Saitama, Japan
    Br J Pharmacol 116:3274-8. 1995
    ..4. These results suggest that the ataxia of the rolling mouse may be due to dysfunction of the cerebellum and VTA, and that amelioration by TRH and TA-0910 could result from metabolic normalization of the VTA...
  74. ncbi The type 1 inositol 1,4,5-trisphosphate receptor gene is altered in the opisthotonos mouse
    V A Street
    Department of Otolaryngology, University of Washington School of Medicine, Seattle 98195, USA
    J Neurosci 17:635-45. 1997
    ..These data suggest that the convulsions and ataxia observed in opt mice may be caused by the physiological dysregulation of a functional IP3R1 protein...
  75. ncbi Regional difference in corticotropin-releasing factor immunoreactivity in mossy fiber terminals innervating calretinin-immunoreactive unipolar brush cells in vestibulocerebellum of rolling mouse Nagoya
    Masahiro Ando
    Department of Otolaryngology, University of Tokushima Graduate School Institute of Health Biosciences, Tokushima 770 8503, Japan
    Brain Res 1063:96-101. 2005
    ..CRF may alter CR-positive UBC-mediated excitatory pathways in the lobule X of RMN and may disturb functions of the lobule X such as cerebellar adaptation for linear motion of the head...
  76. ncbi Impaired motor skills on static and mobile beams in lurcher mutant mice
    N Le Marec
    Hotel Dieu Hospital, Neurology Service, University of Montreal, Quebec, Canada
    Exp Brain Res 116:131-8. 1997
    ..These results indicate that, although lurcher mutants are limited in their capacity to execute motor coordination tasks, postural sensorimotor learning is not abolished in the absence of cerebellar cortical output neurons...
  77. ncbi Mutations in the Cacnl1a4 calcium channel gene are associated with seizures, cerebellar degeneration, and ataxia in tottering and leaner mutant mice
    J Doyle
    Biology Division, Oak Ridge National Laboratory, Tennessee 37831 8077, USA
    Mamm Genome 8:113-20. 1997
    ....
  78. ncbi Expression of tyrosine hydroxylase in cerebellar Purkinje neurons of the mutant tottering and leaner mouse
    M C Austin
    Unit on Behavioral Neuropharmarcology, National Institute of Mental Health, Bethesda, MD 20892
    Brain Res Mol Brain Res 15:227-40. 1992
    ..The present findings demonstrate that the classically GABAergic Purkinje cells in the cerebellum express low levels of TH, and that the mutant tottering and leaner strains of mice express extremely high levels of mRNA and protein for TH...
  79. pmc Carbonic anhydrase-related protein VIII deficiency is associated with a distinctive lifelong gait disorder in waddles mice
    Yan Jiao
    Department of Orthopedic Surgery Campbell Clinic and Pathology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Genetics 171:1239-46. 2005
    ..These data indicate that the wdl mouse is a Car8 null mutant and that CAR8 plays a central role in motor control...
  80. ncbi Neurons tend to stop migration and differentiate along the cortical internal plexiform zones in the Reelin signal-deficient mice
    Hidenori Tabata
    Department of Molecular Neurobiology, Institute of DNA Medicine, Jikei University School of Medicine, Minato ku, Tokyo, Japan
    J Neurosci Res 69:723-30. 2002
    ..These results suggest that the abnormal positioning of neurons in the Reelin-signal-deficient mice is caused, at least in part, by abnormal formation of the internal plexiform zone in the mutant cortex...
  81. ncbi Involvement of reelin and Cajal-Retzius cells in the developmental formation of vertical columnar structures in the cerebral cortex: evidence from the study of mouse presubicular cortex
    Shigeyuki Nishikawa
    Laboratory of Neurobiology, Department of Neurosurgery, Kumamoto University Medical School, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Cereb Cortex 12:1024-30. 2002
    ..Based on the present findings, we hypothesize that reelin and Cajal-Retzius cells regulate the developmental formation of not only horizontal laminations, but also vertical columnar structures in the cerebral cortex...
  82. ncbi Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease
    Cheryl L Wellington
    Centre for Molecular Medicine and Therapeutics, British Columbia Children s and Women s Hospital, Vancouver, British Columbia, Canada
    J Neurosci 22:7862-72. 2002
    ....
  83. ncbi Dissection of the cellular and molecular events that position cerebellar Purkinje cells: a study of the math1 null-mutant mouse
    Patricia Jensen
    University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Neurosci 22:8110-6. 2002
    ..This finding demonstrates that Purkinje cell migration is not solely dependent on Reelin signaling from the EGL and is likely caused by Reelin signals emanating from the nuclear transitory zone or the ventricular zone, or both...
  84. ncbi Adult neurogenesis and schizophrenia: a window on abnormal early brain development?
    C T Toro
    University of Manchester, UK
    Schizophr Res 90:1-14. 2007
    ..This is particularly relevant for brain disorders with developmental origins such as schizophrenia...
  85. ncbi Disruption of cerebellar granule cell development in the Pax6 mutant, Sey mouse
    Douglas James Swanson
    Department of Anatomy and Neurobiology, Center of Excellence in Genomics and Bioinformatics, University of Tennessee Health Sciences Center, 515 LINK Building, 855 Monroe Avenue, Memphis, TN 38163, USA
    Brain Res Dev Brain Res 160:176-93. 2005
    ..Thus, through its guidance of granule cell development, Pax6 also has a strong influence on many of the cellular programs that guide the morphogenesis of the entire cerebellum...
  86. ncbi Differential expression of T-type calcium channels in P/Q-type calcium channel mutant mice with ataxia and absence epilepsy
    Sang Soep Nahm
    Department of Human Anatomy and Medical Neurobiology, College of Medicine, Texas A and M University System Health Science Center, College Station, Texas 77843 1114, USA
    J Neurobiol 62:352-60. 2005
    ..These results suggest that differential expression of T-type calcium channels in the leaner cerebellum may be involved in the observed movement disorders...
  87. ncbi Developmental roles of p73 in Cajal-Retzius cells and cortical patterning
    Gundela Meyer
    Department of Anatomy, University La Laguna, 38071 La Laguna, Tenerife, Spain
    J Neurosci 24:9878-87. 2004
    ....
  88. ncbi Purkinje cell spinogenesis during architectural rewiring in the mature cerebellum
    Roberta Cesa
    Rita Levi Montalcini Center for Brain Repair, Department of Neuroscience, University of Turin, C so Raffaello 30, 10125 Turin, Italy
    Eur J Neurosci 22:579-86. 2005
    ..Thus, spinogenesis is guided by two different mechanisms; a rapid one related to changes in homotypic remodeling and a slower one, which requires the removal of a competitive afferent...
  89. ncbi Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration
    Naoya Yamashita
    Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Neurosci 26:13357-62. 2006
    ..Loss of crmp1 in a dab1 heterozygous background led to the disruption of hippocampal lamination, a Reeler-like phenotype. In addition to axon guidance, CRMP1 regulates neuronal migration by mediating Reln signaling...
  90. pmc Carbonic anhydrase related protein 8 mutation results in aberrant synaptic morphology and excitatory synaptic function in the cerebellum
    Michiru Hirasawa
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3V6
    Mol Cell Neurosci 35:161-70. 2007
    ..Thus, Car8 plays a critical role in synaptogenesis and/or maintenance of proper synaptic morphology and function in the cerebellum...
  91. ncbi Increased truncated TrkB receptor expression and decreased BDNF/TrkB signaling in the frontal cortex of reeler mouse model of schizophrenia
    Anilkumar Pillai
    Department of Psychiatry and Health Behavior, Medical College of Georgia and Medical Research Service, Veterans Affairs Medical Center, Augusta, GA 30907, USA
    Schizophr Res 100:325-33. 2008
    ..In summary, molecular processes associated with defective BDNF signaling in reeler mice provide new therapeutic targets for neuroprotective pharmacotherapy for schizophrenia...
  92. ncbi Time course of choice reaction time deficits in the Hdh(Q92) knock-in mouse model of Huntington's disease in the operant serial implicit learning task (SILT)
    Rebecca C Trueman
    School of Biosciences, Cardiff University, Cardiff, Wales, UK
    Behav Brain Res 189:317-24. 2008
    ..The deficit previously found in accuracy and reaction time was present at all ages examined in these Hdh(Q92/Q92) mice; the deficit was not progressive, and did not correlate with the evolution of neuronal nuclear inclusions...
  93. ncbi Reelin, a guidance signal for the regeneration of the entorhino-hippocampal path
    Ping Wu
    Institute of Neurobiology and Laboratory of Neurobiology, Medical College of Henan University, Kaifeng 475004, Henan Province, PR China
    Brain Res 1208:1-7. 2008
    ..Particularly in the dentate gyrus, the fibers meandered around the cells in the hilus and resembled a network. The study concludes that reelin also serves as an important guidance signal for neuroregeneration of the perforant path...
  94. ncbi Identification of a novel brain-specific and Reelin-regulated gene that encodes a protein colocalized with synapsin
    Anelia Kuvbachieva
    Unité de Neurobiologie, Facultés Universitaires ND de la Paix, Namur, Belgium
    Eur J Neurosci 20:603-10. 2004
    ..When expressed as a GFP fusion protein in transfected non-neuronal cells and primary neurons, this protein localizes, respectively, to the nuclear membrane or axonal outgrowths, indicating a function in axonal traffic or signalling...
  95. ncbi Translocation of cytochrome c during cerebellar degeneration in Lurcher and weaver mutant mice
    Sabine Frischmuth
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Department of Physiology, Arnimallee 22, D 14195 Berlin, Germany
    Brain Res Bull 71:139-48. 2006
    ....
  96. ncbi Massive loss of Cajal-Retzius cells does not disrupt neocortical layer order
    Michio Yoshida
    Department of Neurobiology, Pharmacology and Physiology, University of Chicago, IL 60637, USA
    Development 133:537-45. 2006
    ..Our findings indicate, however, that the sheet of reelin-rich CR cells that covers the neocortical primordium is not required to direct layer order...
  97. ncbi Cellular mechanisms involved in the stenosis and obliteration of the cerebral aqueduct of hyh mutant mice developing congenital hydrocephalus
    C Wagner
    Instituto de Histologia y Patologia, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile
    J Neuropathol Exp Neurol 62:1019-40. 2003
    ..The process of ependymal denudation would involve alterations of the surface sialoglycoproteins of the ependymal cells and the interaction of the latter with macrophages...
  98. ncbi Rescue of the reeler phenotype in the dentate gyrus by wild-type coculture is mediated by lipoprotein receptors for Reelin and Disabled 1
    Shanting Zhao
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    J Comp Neurol 495:1-9. 2006
    ....
  99. ncbi Reelin-deficient mice show impaired neurogenesis and increased stroke size
    Seok Joon Won
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Exp Neurol 198:250-9. 2006
    ..These findings suggest that, in addition to its neurodevelopmental effects, Reln deficiency continues to influence neurogenesis and ischemic neuronal injury in the adult brain...
  100. ncbi Reelin-expressing neurons in the anterior commissure and corpus callosum of the rat
    Kazuyo Misaki
    Department of Anatomy and Developmental Neurobiology, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe City 650 0017, Japan
    Brain Res Dev Brain Res 148:89-96. 2004
    ..These results suggest that Reelin may participate in the regulatory mechanism of neuronal activities through the commissure structure during the postnatal periods...
  101. ncbi Receptor-like protein tyrosine phosphatase zeta/RPTP beta is expressed on tangentially aligned neurons in early mouse neocortex
    Kyoji Ohyama
    Department of Anatomy, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Brain Res Dev Brain Res 148:121-7. 2004
    ..These results indicate that PTPzeta is a useful marker for early-generated neocortical neurons in mice: Cajal-Retzius neurons as well as the subplate neurons...

Research Grants63

  1. Beclin 1 Neurodegeneration and Alzheimer's Disease
    Tony Wyss-Coray; Fiscal Year: 2013
    ..If we inhibit this protein degradation process in AD mice they develop more disease. We propose to study this process to try to reduce disease in mice and possibly in AD. ..
  2. EXPRESSION OF GRANULE CELL GABA RECEPTORS
    Adrienne Frostholm; Fiscal Year: 1993
    ..This work will lead to a fundamental understanding of GABAA receptor regulation by cellular interactions...
  3. ROLE OF REELIN IN CONTROL OF CELL MIGRATION IN BRAIN
    Tom Curran; Fiscal Year: 2000
    ..Furthermore, elucidation of the mechanisms responsible for cell migration is critical for the control of tumor invasion and metastasis, particularly in the brain. ..
  4. JAX Neurogenetics Conference
    WAYNE FRANKEL; Fiscal Year: 2004
    ..This meeting has been held every two years since 1994 and continues to be unique with respect to size, focus and format. ..
  5. Function of Reelin in cortical development
    GABRIELLA D ARCANGELO; Fiscal Year: 2007
    ..Our studies will lead to a better understanding of Reelin function in normal brain development. Furthermore, our findings may have significant implications for cognitive disorders associated with Reelin deficiency. ..
  6. THIRD WORKSHOP IN MOUSE MOLECULAR NEUROGENETICS
    WAYNE FRANKEL; Fiscal Year: 1999
    ..Postdoctoral and graduate students are encouraged to attend, and funds for student travel are requested in this application. This meeting is indeed unique with respect to both focus and format. ..
  7. Opiate Addiction and HIV-1 Induced Release of Cytokines
    William Banks; Fiscal Year: 2006
    ....
  8. Mechanisms of HIV Transport Across the BBB
    William Banks; Fiscal Year: 2004
    ....
  9. PTS1 Regulation of Brain Met Enk Levels in Alcoholism
    William Banks; Fiscal Year: 2004
    ..abstract_text> ..
  10. Prion Transport Across the Blood-Brain Barrier
    William Banks; Fiscal Year: 2009
    ..To cause disease, prions must cross the blood-brain barrier to enter the brain. We will determine how prions cross the BBB. Knowing how prions enter the brain should lead to strategies on how to prevent prion diseases. ..
  11. NEUROPHYSIOLOGY DATABASE OF INBRED MUTANT STRAINS
    Jeffrey Noebels; Fiscal Year: 2001
    ..This project will provide the framework for normative data to be used for comparative electrophysiological, behavioral and experimental pharmacology on inbred mouse strains and defined gene mutations. ..
  12. NEURONAL MIGRATION IN THE DEVELOPING BRAIN
    Huaiyu Hu; Fiscal Year: 2003
    ....
  13. Course Development in the Neurobiology of Disease
    Jeffrey Noebels; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  14. Regulation of Laminar Fate in Cerebral Cortex
    Robert Hevner; Fiscal Year: 2006
    ..If molecular fates are aEered in heterochronic or Rein mutant cortex, this would suggest that certain aspects of laminar fate can be regulated post-mitotically. ..
  15. Molecular Studies of Brain Malformations
    Huaiyu Hu; Fiscal Year: 2007
    ....
  16. Parallel Sequence Profiling of Ion Channels in Epilepsy
    Jeffrey Noebels; Fiscal Year: 2008
    ..abstract_text> ..
  17. EPILEPTOGENESIS IN THE AGED CNS
    Peter Patrylo; Fiscal Year: 2002
    ..Thus, by examining synaptic reorganization within the aged CNS they may also provide insight into the basic mechanisms of epilepsy and learning and memory within the overall population. ..
  18. Synapase Modification /Memory Retention /Life Span Model
    Peter Patrylo; Fiscal Year: 2002
    ..abstract_text> ..
  19. Novel Tau-mediated Neurodegeneration Mechanisms
    ADRIANA B FERREIRA; Fiscal Year: 2010
    ..The data obtained could provide useful for the diagnosis, prevention, and eventually the treatment of AD and other tauopathies. ..
  20. Endocannabinoids and cue-induced drug-seeking behavior
    Loren Parsons; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  21. Deficiency of SHP-1 expression and function in multiple sclerosis
    Paul T Massa; Fiscal Year: 2010
    ..abstract_text> ..
  22. Antipsychotic Actions in Models of NMDA Hypofunction
    Gary Duncan; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  23. BDNF Mutants: Genetic Models for Depressive Disorders
    Maribel Rios; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  24. Extracellular Matrix Protein in Innate Immunity
    You Wen He; Fiscal Year: 2007
    ..Results from this proposal will provide novel insights on the mechanisms of the innate immune response and may have implication for clinical treatment of septic shock and other microbe caused diseases. [unreadable] [unreadable]..
  25. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  26. Intrabodies as novel neurological therapeutics
    Anne Messer; Fiscal Year: 2010
    ..These approaches should also be generally applicable for other neurodegenerative diseases that result from abnormal protein folding and accumulation, including Alzheimer's, Parkinson's, and prion diseases. ..
  27. Neuropathology of a Mouse Model for Phenylketonuria
    Jennifer Embury; Fiscal Year: 2008
    ..In addition, she will have continued exposure to and participation in the molecular biological methods of biomedical research through her involvement in the Laipis laboratory. ..
  28. Mouse models for GABA epigenetic dysfunction
    Alessandro Guidotti; Fiscal Year: 2009
    ..abstract_text> ..
  29. GENETIC REGULATION OF FOLATE RESPONSIVE BIRTH DEFECTS
    Richard Finnell; Fiscal Year: 2009
    ..The hypothesis that the Folbp1 receptor functions in complexes with other proteins within the lipid raft of the cell membrane to act as a signaling molecule challenges existing preconceptions concerning the function of this protein. ..
  30. Psychiatric Research Education Program(PREP)
    Carol Tamminga; Fiscal Year: 2007
    ..Together, these features place the UTSWMC Department of Psychiatry in an ideal position to stimulate and train the next generation of basic and clinical psychiatric researchers. ..
  31. Function of FMRP in the Mouse Olfactory System
    John Larson; Fiscal Year: 2007
    ..Such new information would be vital for evaluating novel treatment strategies for a class of developmental disabilities. [unreadable] [unreadable]..
  32. Genetic remodeling of Vagal Afferent Organization
    Edward Fox; Fiscal Year: 2009
    ..Moreover, it will form an essential foundation for further research on the development of, and the structural and functional organization of, the diverse systems that form the vagal sensorium. ..
  33. MOLECULAR BASIS OF HEREDITARY NEURALGIC AMYOTROPHY
    PHILLIP CHANCE; Fiscal Year: 2008
    ..Moreover, characterization of the HNA gene may have broader pathophysiological and therapeutic implications for more common idiopathic forms of brachial neuropathy. [unreadable] [unreadable]..
  34. Comparitive Antipsychotic Drug Actions on Brain Neurochemistry
    Carol Tamminga; Fiscal Year: 2007
    ..Concentration on mouse behaviors, neurochemistry and behavior will advance studies aimed at kinetic applications. ..
  35. SENSITIZATION AND CONDITIONING WITH ETHANOL
    KENT BERRIDGE; Fiscal Year: 2006
    ..abstract_text> ..
  36. MOUSE MODELS AND PHARMACOTHERAPIES FOR DOWN SYNDROME
    Alberto Costa; Fiscal Year: 2003
    ....
  37. Intrabody Therapy of Parkinson's Disease
    Anne Messer; Fiscal Year: 2003
    ..Long-term goals include administering these antibody reagents via gene therapy vectors, or as stable, multi-functional proteins. ..
  38. PARTIAL DOPAMINEAGONIST TREATMENT OF SCHIZOPHRENIA
    Carol Tamminga; Fiscal Year: 2002
    ..These data will predict and later help us to select optimal agonist intrinsic activity ior clinical testing for antipsychotic actvity, duration of therapeutic action, and side effects. ..
  39. PINEAL OPIOID RECEPTORS & ANALGESIC ACTION OF MELATONIN
    Manuchair Ebadi; Fiscal Year: 2002
    ..Therefore, future research must synthesize highly efficacious melatonin analogues capable of providing maximum analgesia and hopefully being devoid of addiction liability now associated with currently available narcotics. ..
  40. Use of Clenbuterol for Enhancement of Stem Cell Therapy
    Richard Zeman; Fiscal Year: 2002
    ..The method will be patented, licensed and marketed as a new therapy. ..
  41. SYNAPTIC PLASTICITY IN HIPPOCAMPAL EPILEPTOGENESIS
    Gary Clark; Fiscal Year: 2002
    ..Experiments are proposed to ascertain the role of these signal transduction mechanisms in the enhanced release of excitatory transmitter by PAF receptor activation. ..
  42. COCAINE REWARD AND 5 HT 1B RECEPTORS--NEURAL MECHANISMS
    Loren Parsons; Fiscal Year: 2002
    ....
  43. International meeting Neural Transplantation and Repair
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2002
    ..In addition, previous statistics demonstrate that we have favored women and minorities in the past (33% of the travel award recipients for this years' meeting were women, and women serve on all the committees in our organization). ..
  44. MOUSE MODEL OF RETARDATION IN DOWNS SYNDROME
    Zygmunt Galdzicki; Fiscal Year: 2003
    ..In addition the outcome of this research will include further understanding of the role of PKA and PKC and voltage-dependent channels and NMDA- and AMPA-receptors in the mechanisms that are behind LTP and LTD. ..
  45. New PET Radiotracers-Monoamine Transporters
    Michael Kilbourn; Fiscal Year: 2003
    ....
  46. Reelin and GAD67 Downregulation
    Erminio Costa; Fiscal Year: 2005
    ....
  47. Characterization of N-type Ca channels in growth cones
    Maureen McEnery; Fiscal Year: 2005
    ....
  48. Arrowsmith Data Mining Techniques in Neuro-Informatics
    NEIL SMALHEISER; Fiscal Year: 2005
    ..Because of the generality of the Arrowsmith approach, it may be applied to a wide range of biomedical problems and, indeed, to conduct searches within or across any databases that contain textual material. ..
  49. Use of Tempol for Spinal Cord Injury
    Richard Zeman; Fiscal Year: 2004
    ..Optimization of tempol treatment may lead to a therapeutic modality for SCI. ..
  50. PHARMACOLOGY--ALLOSTERIC MODULATORS OF GABAA RECEPTORS
    Alessandro Guidotti; Fiscal Year: 2002
    ....
  51. 5-HTIB RECEPTORS AND MECHANISMS OF ETHANOL REINFORCEMENT
    Loren Parsons; Fiscal Year: 2005
    ..abstract_text> ..
  52. REELIN DEFICIENCY--MODEL FOR SCHIZOPHRENIA VULNERABILITY
    Alessandro Guidotti; Fiscal Year: 2004
    ....
  53. THE ROLE OF AGRIN IN THE DEVELOPMENT OF CENTRAL NEURONS
    Adriana Ferreira; Fiscal Year: 2007
    ..abstract_text> ..
  54. Human Epilepsy Genetics Neuronal Migration Disorders
    Christopher Walsh; Fiscal Year: 2008
    ..Identifying the genes that cause recessive neuronal migration disorders of the cerebral cortex would be important for understanding normal human brain development and evolution, as well as epilepsy pathogenesis. ..
  55. CNTF RECEPTORS AND NEUROPROTECTION AFTER BRAIN TRAUMA
    JOHN MACLENNAN; Fiscal Year: 2002
    ..Finally, the generality of the results will be examined by similarly studying the role of CNTF receptors and CNTF in trigeminal motor neuron responses to injury (Specific Aim 5). ..
  56. Pattern Recognition Molecule Mindin As Adjuvant
    You Wen He; Fiscal Year: 2007
    ..Third, Mindin fused DNA plasmids will be examined for their efficacy in protecting influenza virus infection. [unreadable] [unreadable]..
  57. REGULATION OF NEUROTRANSMISSION AND BEHAVIOR
    Michael Wilson; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  58. Transcriptional regulation of pontine development
    E Litwack; Fiscal Year: 2009
    ..Studying the molecular mechanisms of hindbrain development will lead to a greater understanding of these disorders, and identify potential therapeutic targets for their treatment. ..
  59. RGS Protein (2,4,9,10) Survey in Schizophrenia
    Michael Vogel; Fiscal Year: 2005
    ..Thus, we can accomplish this experiment in a timely manner. ..