mutant strains mice

Summary

Summary: Mice bearing mutant genes which are phenotypically expressed in the animals.

Top Publications

  1. ncbi RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
    Y Shinkai
    Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Cell 68:855-67. 1992
  2. ncbi Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
    M Gautam
    Department of Anatomy and Neurobiology, Washington University Medical School St Louis, Missouri 63110, USA
    Cell 85:525-35. 1996
  3. ncbi Identification of sequential events and factors associated with microglial activation, migration, and cytotoxicity in retinal degeneration in rd mice
    Hui Yang Zeng
    Peking University Eye Centre, Peking University Third Hospital, Beijing, China
    Invest Ophthalmol Vis Sci 46:2992-9. 2005
  4. pmc A coordinated change in chemokine responsiveness guides plasma cell movements
    D C Hargreaves
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Exp Med 194:45-56. 2001
  5. ncbi Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
    D Lyden
    Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
    Nat Med 7:1194-201. 2001
  6. ncbi Sox2 is required for sensory organ development in the mammalian inner ear
    Amy E Kiernan
    MRC Institute of Hearing Research, University of Nottingham, Nottingham NG7 2RD, UK
    Nature 434:1031-5. 2005
  7. ncbi Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
    R Watanabe-Fukunaga
    Osaka Bioscience Institute, Japan
    Nature 356:314-7. 1992
  8. pmc Requirement for NF-kappaB in osteoclast and B-cell development
    G Franzoso
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 11:3482-96. 1997
  9. ncbi Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase
    C Bowes
    Jules Stein Eye Institute, University of California, School of Medicine, Los Angeles 90024
    Nature 347:677-80. 1990
  10. ncbi Hedgehog signalling in the mouse requires intraflagellar transport proteins
    Danwei Huangfu
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nature 426:83-7. 2003

Detail Information

Publications285 found, 100 shown here

  1. ncbi RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
    Y Shinkai
    Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Cell 68:855-67. 1992
    ..Because the SCID phenotype was the only obvious abnormality detected in RAG-2 mutant mice, RAG-2 function and V(D)J recombinase activity, per se, are not required for development of cells other than lymphocytes...
  2. ncbi Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
    M Gautam
    Department of Anatomy and Neurobiology, Washington University Medical School St Louis, Missouri 63110, USA
    Cell 85:525-35. 1996
    ....
  3. ncbi Identification of sequential events and factors associated with microglial activation, migration, and cytotoxicity in retinal degeneration in rd mice
    Hui Yang Zeng
    Peking University Eye Centre, Peking University Third Hospital, Beijing, China
    Invest Ophthalmol Vis Sci 46:2992-9. 2005
    ..To elucidate the role of activated microglia in the photoreceptor apoptosis of rd mice by identifying sequential events and factors associated with microglial activation, migration, and cytotoxicity during retinal degeneration...
  4. pmc A coordinated change in chemokine responsiveness guides plasma cell movements
    D C Hargreaves
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Exp Med 194:45-56. 2001
    ..Our findings indicate that as B cells differentiate into plasma cells they undergo a coordinated change in chemokine responsiveness that regulates their movements in secondary lymphoid organs and promotes lodgment within the bone marrow...
  5. ncbi Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
    D Lyden
    Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
    Nat Med 7:1194-201. 2001
    ..These data demonstrate that recruitment of VEGF-responsive BM-derived precursors is necessary and sufficient for tumor angiogenesis and suggest new clinical strategies to block tumor growth...
  6. ncbi Sox2 is required for sensory organ development in the mammalian inner ear
    Amy E Kiernan
    MRC Institute of Hearing Research, University of Nottingham, Nottingham NG7 2RD, UK
    Nature 434:1031-5. 2005
    ....
  7. ncbi Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
    R Watanabe-Fukunaga
    Osaka Bioscience Institute, Japan
    Nature 356:314-7. 1992
    ..The lpr mice develop lymphadenopathy and suffer from a systemic lupus erythematosus-like autoimmune disease, indicating an important role for Fas antigen in the negative selection of autoreactive T cells in the thymus...
  8. pmc Requirement for NF-kappaB in osteoclast and B-cell development
    G Franzoso
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 11:3482-96. 1997
    ..These findings now establish critical roles for NF-kappaB in development and expand its repertoire of roles in the physiology of differentiated hematopoietic cells...
  9. ncbi Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase
    C Bowes
    Jules Stein Eye Institute, University of California, School of Medicine, Los Angeles 90024
    Nature 347:677-80. 1990
    ..Here we present evidence that the candidate cDNA is the murine homologue of bovine phosphodiesterase beta cDNA. We conclude that the mouse rd locus encodes the rod photoreceptor cGMP-phosphodiesterase beta subunit...
  10. ncbi Hedgehog signalling in the mouse requires intraflagellar transport proteins
    Danwei Huangfu
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nature 426:83-7. 2003
    ..Our data show that IFT machinery has an essential and vertebrate-specific role in Hedgehog signal transduction...
  11. ncbi SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine
    W S Alexander
    The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Cell 98:597-608. 1999
    ..Our data indicate that SOCS1 is a key modulator of IFNgamma action, allowing the protective effects of this cytokine to occur without the risk of associated pathological responses...
  12. ncbi Atm-deficient mice: a paradigm of ataxia telangiectasia
    C Barlow
    Laboratory of Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 86:159-71. 1996
    ..Atm-disrupted mice recapitulate the ataxia telangiectasia phenotype in humans, providing a mammalian model in which to study the pathophysiology of this pleiotropic disorder...
  13. pmc Monocytes give rise to mucosal, but not splenic, conventional dendritic cells
    Chen Varol
    Department of Immunology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Exp Med 204:171-80. 2007
    ..The grafted monocytes give rise to DCs in the intestinal lamina propria and lung, but not to conventional CD11chigh DCs in the spleen, which develop during homeostasis from MDPs without a monocytic intermediate...
  14. ncbi A severe combined immunodeficiency mutation in the mouse
    G C Bosma
    Nature 301:527-30. 1983
    ..These mice, therefore, represent a new model for investigating how lymphoid differentiation may be impaired in the disease state and regulated in the normal state...
  15. ncbi Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor
    K M Zsebo
    Amgen Inc, Amgen Center, Thousand Oaks, California 91320
    Cell 63:213-24. 1990
    ..In vivo administration of SCF can reverse the macrocytic anemia and locally repair the mast cell deficiency of Sl/Sld mice. We have also provided biological and physical evidence that SCF is a ligand for the c-kit receptor...
  16. ncbi Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination
    J Essers
    Medical Genetics Center, Department of Cell Biology and Genetics, Erasmus University Rotterdam, The Netherlands
    Cell 89:195-204. 1997
    ..Thus, mRAD54 is not required for the recombination processes that generate functional immunoglobulin and T cell receptor genes...
  17. pmc Mutations of the protocadherin gene PCDH15 cause Usher syndrome type 1F
    Z M Ahmed
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD, USA
    Am J Hum Genet 69:25-34. 2001
    ..A Northern blot probed with the PCDH15 cytoplasmic domain showed expression in the retina, consistent with its pathogenetic role in the retinitis pigmentosa associated with USH1F...
  18. pmc Chemokine requirements for B cell entry to lymph nodes and Peyer's patches
    Takaharu Okada
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 196:65-75. 2002
    ..These findings establish the principal chemokine and chemokine receptor requirements for B cell entry to lymph nodes and Peyer's patches...
  19. ncbi Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation
    L Robb
    Walter and Eliza Hall Institute of Medical Research, Cooperative Research Centre for Cellular Growth Factors, Victoria, Australia
    Nat Med 4:303-8. 1998
    ..These observations reveal a previously unrecognized critical role for IL-11 signaling in female reproduction...
  20. ncbi Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31
    Philomena Mburu
    MRC Mammalian Genetics Unit and UK Mouse Genome Centre, Harwell, Oxon OX11 ORD, UK
    Nat Genet 34:421-8. 2003
    ..Our findings suggest that this novel PDZ domain-containing molecule acts as an organizer of submembranous molecular complexes that control the coordinated actin polymerization and membrane growth of stereocilia...
  21. pmc Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice
    Masahiro Fukaya
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Proc Natl Acad Sci U S A 100:4855-60. 2003
    ....
  22. ncbi Profound block in thymocyte development in mice lacking p56lck
    T J Molina
    Ontario Cancer Institute, University of Toronto, Canada
    Nature 357:161-4. 1992
    ..Mature, single-positive thymocytes are not detectable in these mice and there are only very few peripheral T cells. These results illustrate the crucial role of this T-cell-specific tyrosine kinase in the thymocyte development...
  23. pmc Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase beta-subunit gene of the rd mouse
    S J Pittler
    Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030
    Proc Natl Acad Sci U S A 88:8322-6. 1991
    ..The results strongly argue for the nonsense mutation being responsible for retinal degeneration in the rd mouse...
  24. ncbi Epithelial laminin alpha5 is necessary for distal epithelial cell maturation, VEGF production, and alveolization in the developing murine lung
    Nguyet M Nguyen
    Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Biol 282:111-25. 2005
    ....
  25. ncbi Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling
    Kristen Johnson
    Department of Molecular Genetics and Cell Biology, University of Chicago, 929 East 57 th Street, GCIS W522, Chicago, IL 60637, USA
    Immunity 28:335-45. 2008
    ..We propose that IRF-4 coordinates the two pathways regulating light-chain recombination by positioning pre-B cells away from IL-7-expressing stromal cells...
  26. ncbi Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule
    P Engel
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 3:39-50. 1995
    ..These experiments indicate that CD19 functions to define signaling thresholds for cell surface receptors that regulate B lymphocyte selection, activation, and differentiation...
  27. ncbi Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins
    Sihem Boudina
    Division of Endocrinology, Metabolism, and Diabetes, Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Diabetes 56:2457-66. 2007
    ..Mitochondrial uncoupling has been proposed to contribute to these metabolic abnormalities but has not been directly demonstrated...
  28. pmc Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice
    Heiko Bugger
    Division of Endocrinology, Metabolism and Diabetes, and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Diabetes 58:1986-97. 2009
    ..To elucidate the molecular basis for mitochondrial dysfunction, which has been implicated in the pathogenesis of diabetes complications...
  29. ncbi Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes
    Theo P Hill
    Research Institute for Molecular Pathology, Vienna, Austria
    Dev Cell 8:727-38. 2005
    ..Thus, canonical Wnt/beta-catenin signaling is essential for skeletal lineage differentiation, preventing transdifferentiation of osteoblastic cells into chondrocytes...
  30. pmc Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I
    A Matsushima
    Division of Informative Cytology, Institute for Enzyme Research, University of Tokushima, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    J Exp Med 193:631-6. 2001
    ..These results demonstrate that both NIK and IKKalpha are essential for the induction of NF-kappaB through LTbetaR, whereas the NIK-IKKalpha pathway is dispensable in TNFR-I signaling...
  31. ncbi Biology and action of colony--stimulating factor-1
    E R Stanley
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Mol Reprod Dev 46:4-10. 1997
    ..Studies on several of these proteins, including protein tyrosine phosphates 1C, the c-cbl proto-oncogene product, and protein tyrosine phosphatase-phi are discussed...
  32. pmc Expression of Math1 and HES5 in the cochleae of wildtype and Jag2 mutant mice
    P J Lanford
    Department of Cell Biology, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Assoc Res Otolaryngol 1:161-71. 2000
    ..These results are consistent with the hypothesis that activation of Notch via Jagged2 acts to inhibit expression of Math1 in cochlear progenitor cells, possibly through the activity of HES5...
  33. pmc Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice
    D C Bullard
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Exp Med 183:2329-36. 1996
    ..These mice provide strong evidence for the functional importance of selectins in vivo...
  34. ncbi Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice
    M L Arbones
    Cell Genesys, Incorporated, Foster City, California 94404
    Immunity 1:247-60. 1994
    ..Thus, L-selectin plays an essential role in leukocyte homing to lymphoid tissues and sites of inflammation...
  35. ncbi The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages
    T I Roach
    Department of Pathology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63130, USA
    Curr Biol 8:1035-8. 1998
    ..These data demonstrate that SHP-1 is necessary for detachment from alpha m beta 2 integrin-mediated contacts in primary macrophages and suggest that a defect in this pathway may contribute to inflammatory disease...
  36. ncbi c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation
    Mark L Sandberg
    Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Dev Cell 8:153-66. 2005
    ..Cell cycle analyses show that twice as many HSCs from c-Myb(M303V/M303V) animals are actively cycling. Thus c-Myb, through interaction with p300, controls the proliferation and differentiation of hematopoietic stem and progenitor cells...
  37. ncbi Regulation of mouse mast cell protease 6 gene expression by transcription factor encoded by the mi locus
    E Morii
    Department of Pathology, Osaka University Medical School, Japan
    Blood 88:2488-94. 1996
    ..Mutations of each motif significantly reduced the transactivation, suggesting that +-MITF directly transactivated the MMCP-6 gene through these three motifs...
  38. pmc Lineage-specific requirements of beta-catenin in neural crest development
    Lisette Hari
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
    J Cell Biol 159:867-80. 2002
    ..We propose that the requirement of beta-catenin for the specification of melanocytes and sensory neuronal lineages reflects roles of beta-catenin both in Wnt signaling and in mediating cell-cell interactions...
  39. ncbi RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells
    L Wu
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    Immunity 9:839-47. 1998
    ..However, the deficiency in splenic CD8alpha- DEC-205- DC is a direct, stem cell intrinsic effect of the RelB mutation. Thus, RelB selectively regulates a myeloid-related DC lineage...
  40. pmc Impaired learning and motor behavior in heterozygous Pafah1b1 (Lis1) mutant mice
    R Paylor
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 6:521-37. 1999
    ..The behavioral findings also support the use of the Lis1 mutant mice as a model from human type 1 lissencephaly...
  41. pmc A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice
    M D Fleming
    Department of Pathology, Children s Hospital, Boston, Massachusetts 02115, USA
    Genes Dev 15:652-7. 2001
    ..The mutated gene, Sfxn1, is the prototype of a novel family of evolutionarily conserved proteins present in eukaryotes...
  42. ncbi Cyclin D1 provides a link between development and oncogenesis in the retina and breast
    P Sicinski
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Cell 82:621-30. 1995
    ..Thus, steroid-induced proliferation of mammary epithelium during pregnancy may be driven through cyclin D1...
  43. ncbi Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice
    A Imamoto
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030
    Cell 73:1117-24. 1993
    ..These results demonstrate that Src family kinase activity is critically dependent on phosphorylation by Csk and suggest that the regulation of kinase activity may be essential during embryogenesis...
  44. pmc The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome
    Nadia P Belichenko
    Department of Neurology and Neurological Sciences and the Center for Research and Treatment of Down Syndrome, Stanford University Medical Center, Stanford, California 94305 5489, USA
    J Neurosci 29:5938-48. 2009
    ..The stage is now set for studies to decipher the gene(s) that play a conspicuous role in creating these phenotypes...
  45. pmc Regulation of elongation phase of mRNA translation in diabetic nephropathy: amelioration by rapamycin
    Kavithalakshmi Sataranatarajan
    O Brien Kidney Research Center, Department of Medicine, MC 7882, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Am J Pathol 171:1733-42. 2007
    ..These data show that mTOR is an attractive target for amelioration of diabetes-induced renal injury...
  46. ncbi Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling
    Sidne A Omori
    Program of Inflammatory Disease Research, Infectious and Inflammatory Disease Center and Program of Signal Transduction, Cancer Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Immunity 25:545-57. 2006
    ..However, ectopic expression of AID could not fully overcome inhibition of CSR by PI3K, suggesting that PI3K regulates both the expression and function of AID...
  47. ncbi Role of myosin VI in the differentiation of cochlear hair cells
    T Self
    MRC Institute of Hearing Research, University Park, Nottingham, NG7 2RD, United Kingdom
    Dev Biol 214:331-41. 1999
    ....
  48. pmc Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice
    Tomonori Kaifu
    Department of Experimental Immunology and Core Research for Evolutional Science and Technology CREST Program of the Japan Science and Technology Corporation JST, Tohoku University, Sendai, Japan
    J Clin Invest 111:323-32. 2003
    ..These results provide a molecular basis for a unique combination of skeletal and psychotic characteristics of Nasu-Hakola disease as well as for schizophrenia and presenile dementia...
  49. ncbi Pericytes and the pathogenesis of diabetic retinopathy
    Hans Peter Hammes
    Fifth Medical Clinic, Medical Faculty of the University of Heidelberg, Mannheim, Germany
    Diabetes 51:3107-12. 2002
    ..At high vascular endothelial growth factor levels, such as those in the retinopathy of prematurity model, pericyte deficiency leads to reduced inhibition of endothelial proliferation in vivo...
  50. pmc Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity
    S Przedborski
    Department of Neurology, Columbia University, New York 10032, USA
    Proc Natl Acad Sci U S A 93:4565-71. 1996
    ..These results indicate that neuronally derived NO mediates, in part, MPTP-induced neurotoxicity. The similarity between the MPTP model and PD raises the possibility that NO may play a significant role in the etiology of PD...
  51. ncbi Myosin VIIa participates in opsin transport through the photoreceptor cilium
    X Liu
    Departments of Pharmacology and Neurosciences, University of California at San Diego School of Medicine, La Jolla, California 92093 0983, USA
    J Neurosci 19:6267-74. 1999
    ..They demonstrate that a myosin may function in a cilium and suggest that abnormal opsin transport might contribute to blindness in Usher syndrome...
  52. ncbi A role for hematopoietic stem cells in promoting angiogenesis
    N Takakura
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Cell 102:199-209. 2000
    ..HSCs, which express Ang1, directly promoted migration of ECs in vivo and in vitro. These results indicate that HSCs are critical for angiogenesis...
  53. ncbi Prolonged survival of fetal pig islet xenografts in mice lacking the capacity for an indirect response
    Maria Koulmanda
    Islet Transplantation Research Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Xenotransplantation 11:525-30. 2004
    ....
  54. pmc Defective pro alpha 2(I) collagen synthesis in a recessive mutation in mice: a model of human osteogenesis imperfecta
    S D Chipman
    Bone Metabolism Research Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21224
    Proc Natl Acad Sci U S A 90:1701-5. 1993
    ..The oim mouse will facilitate the study of type I collagen-related skeletal disease...
  55. pmc Interleukin 7 receptor-deficient mice lack gammadelta T cells
    K Maki
    Department of Disease Related Gene Regulation Research Sandoz Faculty of Medicine, The Univerisity of Tokyo, Japan
    Proc Natl Acad Sci U S A 93:7172-7. 1996
    ..On the contrary, it is suggested that NK-cell development requires cytokine(s) other than IL-7...
  56. ncbi The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
    R Hakem
    Amgen Institute, Toronto, Ontario, Canada
    Cell 85:1009-23. 1996
    ..Thus, the death of Brca1(5-6) mutant embryos prior to gastrulation may be due to a failure of the proliferative burst required for the development of the different germ layers...
  57. ncbi Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytes
    Cecilia Bondjers
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77, Stockholm, Sweden
    FASEB J 20:1703-5. 2006
    ..The three new brain pericyte markers are signaling molecules implicated in ion transport and intercellular signaling, potentially opening new windows on pericyte function in brain microvessels...
  58. ncbi Phagocytosis and clearance of apoptotic cells is mediated by MER
    R S Scott
    UNC Neuroscience Center, USA
    Nature 411:207-11. 2001
    ..Thus, the Mer receptor tyrosine kinase seems to be critical for the engulfment and efficient clearance of apoptotic cells. This has implications for inflammation and autoimmune diseases such as systemic lupus erythematosus...
  59. ncbi Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice
    J D Hildebrand
    Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cell 99:485-97. 1999
    ..Finally, cytoskeletal polarity within the neuroepithelium is perturbed in mutant embryos. In concert, these observations suggest that Shrm is a critical determinant of the cellular architecture required for proper neurulation...
  60. pmc The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome
    Jesse E Hanson
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305 5345, USA
    J Physiol 579:53-67. 2007
    ....
  61. pmc Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice
    M Kozlowski
    Department of Medicine, University of Toronto, Ontario, Canada
    J Exp Med 178:2157-63. 1993
    ..These observations provide strong evidence that the motheaten phenotypic results from loss-of-function mutations in the PTP1C gene and imply a critical role for PTP1C in the regulation of hemopoietic differentiation and immune function...
  62. pmc Harmonin mutations cause mechanotransduction defects in cochlear hair cells
    Nicolas Grillet
    Department of Cell Biology, Institute for Childhood and Neglected Disease, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuron 62:375-87. 2009
    ..We conclude that harmonin is a UTLD component and contributes to establishing the sensitivity of mechanotransduction channels to displacement...
  63. ncbi Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    F Kontgen
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Genes Dev 9:1965-77. 1995
    ..The ability of exogenous interleukin-2 to restore T Cell, but not B cell, proliferation indicates that Rel regulates the expression of different genes in B and T cells that are crucial for cell division and immune function...
  64. ncbi Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear
    A Zine
    Institute of Physiology, University of Lausanne, 1005 Lausanne, Switzerland
    J Neurosci 21:4712-20. 2001
    ..These data indicate that Hes1 and Hes5 participate together for the control of inner ear hair cell production, likely through the negative regulation of Math1...
  65. pmc Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans
    Qing Yin Zheng
    Jackson Laboratory, Bar Harbor, ME 04609, USA
    Hum Mol Genet 14:103-11. 2005
    ..Altogether, our data indicate that CDH23 and PCDH15 play an essential long-term role in maintaining the normal organization of the stereocilia bundle...
  66. ncbi Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
    Development 126:3047-55. 1999
    ..Subsequent angiogenic sprouting and vessel enlargement involves PDGF-B-dependent vSMC/PC progenitor co-migration and proliferation, and/or PDGF-B-independent new induction of vSMC/PC, depending on tissue context...
  67. ncbi A chemical-genetic approach to studying neurotrophin signaling
    Xi Chen
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 46:13-21. 2005
    ..Thus, Trk knockin mice provide valuable tools for selective, rapid, and reversible inhibition of neurotrophin signaling in vitro and in vivo...
  68. ncbi The mdx mouse skeletal muscle myopathy: I. A histological, morphometric and biochemical investigation
    G R Coulton
    Department of Histopathology, Charing Cross and Westminster Medical School, London
    Neuropathol Appl Neurobiol 14:53-70. 1988
    ..Mdx differs from Duchenne dystrophy principally in that it exhibits a greater degree of compensatory muscle regeneration and an absence of fibro-fatty replacement of muscle fibres...
  69. pmc Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production
    D Hata
    Division of Allergy, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Exp Med 187:1235-47. 1998
    ..Taken together, these results demonstrate an important role for Btk in the full expression of FcepsilonRI signal transduction in mast cells...
  70. ncbi Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells
    M Zijlstra
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts
    Nature 344:742-6. 1990
    ....
  71. ncbi Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage
    Jessica A Gorski
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 22:6309-14. 2002
    ..Structures that are located near the basal ganglia (e.g., the amygdala and endopiriform nuclei) are not uniformly derived from Emx1-expressing cells...
  72. pmc Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus
    Eric J Yager
    The Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 205:711-23. 2008
    ..These observations have important implications for the design of vaccine strategies for the elderly...
  73. ncbi Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene
    R J Smeyne
    Department of Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000
    Nature 368:246-9. 1994
    ..These findings demonstrate that Trk is the primary mediator of the trophic actions of NGF in vivo and that this signalling pathway plays a crucial role in the development of both the peripheral and the central nervous systems...
  74. ncbi Retinal neurodegeneration in the DBA/2J mouse-a model for ocular hypertension
    Frank Schuettauf
    Experimental Ophthalmology, University Eye Hospital, Roentgenweg 11, 72076, Tuebingen, Germany
    Acta Neuropathol 107:352-8. 2004
    ..However, neovasculogenesis and myelin-like bodies are observed during aging. Therefore, the DBA/2J model requires judicious interpretation as a glaucoma model...
  75. ncbi Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence
    G Weeda
    Department of Cell Biology and Genetics, Medical Genetics Center, Erasmus University, Rotterdam P O Box 1738, 3000 DR, Rotterdam, The Netherlands
    Curr Biol 7:427-39. 1997
    ....
  76. ncbi Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene
    H W Tsui
    Toronto Hospital, Ontario, Canada
    Nat Genet 4:124-9. 1993
    ....
  77. ncbi Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
    Edward A Miao
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Nat Immunol 7:569-75. 2006
    ....
  78. ncbi Mice lacking MHC class II molecules
    D Cosgrove
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire de Génie Génétique de l INSERM, Faculte de Medecine, Strasbourg, France
    Cell 66:1051-66. 1991
    ..In short, the class II-negative mice have confirmed some old ideas about lymphocyte differentiation, but have provided some surprises...
  79. pmc Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis
    Yojiro Arinobu
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:18105-10. 2005
    ..Thus, circulating basophils and tissue mast cells share a common developmental stage at which their fate decision might be controlled principally by C/EBPalpha...
  80. pmc Induction and suppression of collagen-induced arthritis is dependent on distinct fcgamma receptors
    S Kleinau
    Department of Genetics and Pathology, Uppsala University, S 75185 Uppsala, Sweden
    J Exp Med 191:1611-6. 2000
    ..In comparison, DBA/1 mice lacking FcgammaRII developed an augmented IgG anticollagen response and arthritis. These observations suggest a crucial role of FcgammaRI and FcgammaRIII in triggering autoimmune arthritis...
  81. ncbi BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
    Darren J Baker
    1 Departments of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA 2 Departments of Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Nat Genet 36:744-9. 2004
    ..Natural aging of wild-type mice is marked by decreased expression of BubR1 in multiple tissues, including testis and ovary. These results suggest a role for BubR1 in regulating aging and infertility...
  82. ncbi Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
    D J Rawlings
    Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024
    Science 261:358-61. 1993
    ..A single conserved residue within the amino terminal unique region of Btk was mutated in XID mice. This change in xid probably interferes with normal B cell signaling mediated by Btk protein interactions...
  83. ncbi Microglia in colony-stimulating factor 1-deficient op/op mice
    G Blevins
    Canadian Network of Centres of Excellence, Department of Anatomy, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    J Neurosci Res 40:535-44. 1995
    ..Based on our experiments, it seems that microglia are CSF-1 dependent but in op/op mice (in which CSF-1 is absent) microglia may use other locally produced factors...
  84. ncbi Spotlight on spotted mice: a review of white spotting mouse mutants and associated human pigmentation disorders
    Laura L Baxter
    Mouse Embryology Section, Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Pigment Cell Res 17:215-24. 2004
    ..We describe our current understanding of how these genes function in development, and explore their complex roles regulating the various stages of melanocyte development...
  85. ncbi Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J)
    S Tole
    Department of Neurobiology, University of Chicago, Chicago, Illinois, 60637, USA
    Dev Biol 217:254-65. 2000
    ..Our findings suggest that in dorsal telencephalon Gli3 is needed to repress ventral telencephalic identity...
  86. ncbi Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse
    M Frasson
    Laboratoire de Physiopathologie Retinienne, Clinique Ophthalmologique, Universite Louis Pasteur, Centre Hospitalier Regional Universitaire, Strasbourg, France
    Invest Ophthalmol Vis Sci 40:2724-34. 1999
    ..To evaluate the neuroprotective potential of glial cell line-derived neurotrophic factor (GDNF) in the retinal degeneration (rd/rd) mouse model of human retinitis pigmentosa...
  87. pmc X chromosome-linked muscular dystrophy (mdx) in the mouse
    G Bulfield
    Proc Natl Acad Sci U S A 81:1189-92. 1984
    ..Linkage analysis with four X chromosome loci indicates that mdx maps in the Hq Bpa region of the mouse X chromosome. This gives a gene order of mdx-Tfm-Pgk-1-Ags, the same as for the equivalent genes on the human X chromosome...
  88. ncbi Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    M H Kaplan
    Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Immunity 4:313-9. 1996
    ..These results demonstrate that, despite the existence of multiple signaling pathways activated by IL-4, Stat6 is essential for mediating responses to IL-4 lymphocytes...
  89. ncbi Murine muscular dystrophy caused by a mutation in the laminin alpha 2 (Lama2) gene
    H Xu
    La Jolla Cancer Research Foundation, California 92037
    Nat Genet 8:297-302. 1994
    ..One mRNA is translated into an alpha 2 polypeptide with a deletion in domain VI. The truncated protein apparently lacks important qualities of the wild type protein and is unable to provide sufficient muscle stability...
  90. pmc Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells
    J A Piedrahita
    Department of Pathology and Curriculum in Genetics, University of North Carolina, Chapel Hill 27599 7525
    Proc Natl Acad Sci U S A 89:4471-5. 1992
    ..Mice homozygous for the disrupted gene were produced from the heterozygotes; they appear healthy, even though they have no apolipoprotein E in their plasma...
  91. ncbi The role of Hoxa-3 in mouse thymus and thyroid development
    N R Manley
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Development 121:1989-2003. 1995
    ..This variability suggests the presence of a compensating gene or genes, whose utilization is stochastic. A reasonable candidate for providing this compensatory function is the paralogous gene Hoxb-3...
  92. ncbi Murine FGFR-1 is required for early postimplantation growth and axial organization
    C X Deng
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115
    Genes Dev 8:3045-57. 1994
    ..Such abnormalities are unlikely to be caused by intrinsic blocks in mesodermal differentiation, as FGFR-1-deficient ES cell lines form teratomas consisting of many mesodermal cell types...
  93. ncbi Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis
    Yaojiong Wu
    161 HMRC, University of Alberta, 113 Street and 87 Avenue, Edmonton, Alberta T6G 2E1, Canada
    Stem Cells 25:2648-59. 2007
    ..Thus, our data suggest that BM-MSCs promote wound healing through differentiation and release of proangiogenic factors. Disclosure of potential conflicts of interest is found at the end of this article...
  94. ncbi Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane
    J H Miner
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri, 63110, USA
    Dev Biol 217:278-89. 2000
    ....
  95. ncbi SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
    J C Marine
    Howard Hughes Medical Institute, and Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cell 98:609-16. 1999
    ..Introducing a RAG2 or IFNgamma deficiency eliminates lethality. The results demonstrate that lymphocytes are critical to SOCS1-associated perinatal lethality and implicate SOCS1 in lymphocyte differentiation or regulation...
  96. ncbi An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria
    Jaan Olle Andressoo
    Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Cancer Genomics Center, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Cancer Cell 10:121-32. 2006
    ..Like CS fibroblasts, XPCS and TTD fibroblasts from human and mouse showed evidence of defective repair of oxidative DNA lesions that may underlie these segmental progeroid symptoms...
  97. pmc Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes
    Veronique Masson
    Laboratory of Tumor and Development Biology, University of Liege, Liege, Belgium
    FASEB J 19:234-6. 2005
    ..Our data demonstrate for the first time in an experimental model that MMP-2 and MMP-9 cooperate in promoting the in vivo invasive and angiogenic phenotype of malignant keratinocytes...
  98. ncbi Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway
    B Wehrle-Haller
    Institute of Neuroscience, University of Oregon, Eugene 97403
    Development 121:731-42. 1995
    ..In contrast, membrane-bound Steel factor appears to promote melanocyte precursor survival in the dermis...
  99. pmc Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome
    Vardhan S Dani
    Department of Biology and Volen Center for Complex Systems, Brandeis University, MS 008, Waltham, MA 02454 9110, USA
    Proc Natl Acad Sci U S A 102:12560-5. 2005
    ..These findings provide the first detailed electrophysiological analysis of Mecp2-mutant mice and provide a framework for understanding the pathophysiology of the disease and tools for studying the underlying disease mechanisms...
  100. pmc Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis
    Stuart N Peirson
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
    Nucleic Acids Res 31:e73. 2003
    ..We have automated this method to provide a means of streamlining the real-time PCR process, enabling analysis of experimental samples based upon their own reaction kinetics rather than those of artificial standards...
  101. ncbi Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
    Luigi Franchi
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Immunol 7:576-82. 2006
    ..Thus, detection of flagellin through Ipaf induces caspase-1 activation independently of Toll-like receptor 5 in salmonella-infected and lipopolysaccharide-tolerized macrophages...

Research Grants62

  1. PROPERTIES OF AXONAL TUBULIN RELATED TO NEURONAL GROWTH
    SCOTT BRADY; Fiscal Year: 2003
    ..The goal is to understand dynamics of the neuronal cytoskeleton that play critical roles in development, regeneration, and neuropathology. ..
  2. Role of the developmental regulator Gon4-like in B lymphopoiesis
    JOHN D COLGAN; Fiscal Year: 2011
    ..Further, the knowledge gained will provide new insights regarding the fundamental processes that contribute to immune dysfunction or the development of lymphoid cancers. ..
  3. Mechanism Underlying Neurodegeneration Caused by Dysfunction of Pre-mRNA Splicing
    Yichang Jia; Fiscal Year: 2012
    ..The potential outcome from the experiments outlined in this proposal will not only help us better understand the disease mechanisms of these diseases but will also provide a basis for the development of rational therapeutic strategies. ..
  4. Proopiomelanocortin gene expression and obesity
    MALCOLM JAMES LOW; Fiscal Year: 2013
    ....
  5. Role of the developmental regulator Gon4-like in B lymphopoiesis
    JOHN D COLGAN; Fiscal Year: 2013
    ..Such knowledge will provide novel insights regarding the relationships between impairment of B cell development and the appearance of immunodeficiencies or B cell progenitor-derived lymphoid cancers. ..
  6. Function and Mechanism of CUL4 E3 Ligases in Human Diseases
    Yue Xiong; Fiscal Year: 2013
    ..Finally, we propose to determine broadly the function of CUL4B in the regulation of chromatin modification and gene expression. ..
  7. Molecular Genetics of Age-Dependent Retinal Degeneration
    Akihiro Ikeda; Fiscal Year: 2013
    ....
  8. Therapeutic rescue of an olfactory ciliopathy
    JEREMY MCINTYRE; Fiscal Year: 2012
    ....
  9. Metabolic Research Animal Facility
    Robert E Braun; Fiscal Year: 2011
    ..One will be furnished with mobile workstations to maximize flexible configuration. The project will be overseen by John Fitzpatrick, P.E., Senior Director of Facilities Services, who will serve as Facilities Person/Project Manager. ..
  10. Shock Center for Aging Research at The Jackson Laborato*
    David Harrison; Fiscal Year: 2009
    ..In sum, the Nathan Shock Center at The Jackson Laboratory will lead to enhanced resources for the international community and better understanding of the molecular mechanisms at work in aging and its associated disorders. ..
  11. Genetics of Sagg: A Heritable Mouse Model for Cutis Laxa
    Paul Christner; Fiscal Year: 2004
    ..These experiments will also include genes encoding enzymes involved in the degradation and removal of the EMC. These studies will be undertaken in order to elucidate the downstream molecular events resulting from the Sagg mutation. ..
  12. Preservation of ejaculated mouse spermatozoa
    MONIKA WARD; Fiscal Year: 2006
    ..Our expectations are that the results of this application will allow us to recommend ICSI with preserved ejaculated spermatozoa as a simple and efficient method for preservation of valuable mouse genomes. ..
  13. GABP-controlled gene regulatory network in T lymphocytes
    Hai Hui Xue; Fiscal Year: 2009
    ..This knowledge will provide a scientific basis for manipulating outcomes of hematopoietic stem cell differentiation and immune response under physiological and pathological conditions. ..
  14. MOLECULAR BASIS OF THE TOTTERING PHENOTYPE
    ELLEN HESS; Fiscal Year: 1999
    ..The results of this proposal will furnish new insights into the disease process resulting in the tottering mouse phenotype which may be generalized to the genesis and maintenance of epilepsies and/or ataxia in humans. ..
  15. DIZZINESS IN OLDER PEOPLE
    Phyllis Jean Linton; Fiscal Year: 2006
    ..We will manipulate conditions such that we may induce young cells to "age" (i.e., increased longevity) and vice versa, and determine if these manipulations induce alterations in antigen specific function (i.e., IL-2 production). ..
  16. FETAL TROPHOBLASTS MAINTAIN MATERNAL TOLERANCE
    John Russell; Fiscal Year: 1999
    ..Successful completion of these experiments would provide the first direct evidence that either of these mechanisms is important in maintaining maternal tolerance to the fetus. ..
  17. Roles of bacterial flora in endotoxin shock mediated vi*
    Koichi Kobayashi; Fiscal Year: 2006
    ..This research is performed primarily in the Institute of Microbiology AS CR in the Czech Republic in collaboration with Helena Tlaskalova as an extension of NIH grant # P01 AI36529. ..
  18. STARTLE GATING AND LOCOMOTION IN D2-FAMILY KNOCKOUT MICE
    Mark Geyer; Fiscal Year: 2004
    ..This information will have important implications for the further development of therapeutic approaches to the treatment of both schizophrenia and drug abuse. ..
  19. Age-Dependent Increases in Airway Responsiveness by RSV
    Erwin Gelfand; Fiscal Year: 2007
    ..abstract_text> ..
  20. SEROTONIN 5HT2C RECEPTORS AND THE ACTIONS OF COCAINE
    Laurence Tecott; Fiscal Year: 2001
    ..These studies will provide insights into the serotonergic mechanisms of cocaine action and into the mechanism through which a genetic alteration of serotonin system function leads to a heritable alteration in cocaine responsiveness. ..
  21. FOXP3 Gene Therapy for Immunomodulation in Diabetes
    ROBERT WILDIN; Fiscal Year: 2001
    ..If both are successful, FOXP3 gene therapy for JODM could be envisioned. ..
  22. TRANSGENIC AND TARGETED MUTANT PRESERVATION
    LEAH DONAHUE; Fiscal Year: 2009
    ..abstract_text> ..
  23. LCQ Deca-XP Ultra Sensitive Ion Trap Mass Spectrometer
    RALPH YOUNT; Fiscal Year: 2003
    ....
  24. Eighth & Ninth International Symposia on Neurobiology & Neuroendocrinology Aging
    Andrzej Bartke; Fiscal Year: 2007
    ..We are also seeking partial support for the expenses of invited speakers from the United States. [unreadable] [unreadable] [unreadable]..
  25. Aging:Mechanisms & Prevention:34th Annual Meeting of AGE
    Andrzej Bartke; Fiscal Year: 2005
    ..Financial assistance will be provided to those in training to encourage their participation in the meeting. ..
  26. 7th Intl Symposium-Neurobiology/Neuroendocrinology/Aging
    Andrzej Bartke; Fiscal Year: 2004
    ..We are also seeking support for the presenters of the Special Lecture and the Keynote Lecture who will be traveling to Bregenz from the United States. ..
  27. Hepatitis C Virus, Alcohol and Host Defense
    Gyongyi Szabo; Fiscal Year: 2007
    ..Results from these studies should reveal molecular and cellular mechanisms by which alcohol interacts with HCV infection to accelerate disease persistence and progression. [unreadable] [unreadable]..
  28. Ethanols role in mediation of monocyte suppression
    Gyongyi Szabo; Fiscal Year: 2009
    ..Investigation of the modulation of IL-10 and IL-12 by alcohol in dendritic cell function may identify biomarkers of alcohol-induced immune depression and reveal potential targets for therapy. ..
  29. Conference--The Biology and Chemistry of Vision
    Wolfgang Baehr; Fiscal Year: 2003
    ..Proposed sessions include topics on the biology and physiology of photoreceptors, human genetics and retinal disease, as well as gene therapy of recessive and dominant dystrophies. ..
  30. COCHLEAR VULNERABILITY/REACTIVE OXYGEN SPECIES
    KEVIN OHLEMILLER; Fiscal Year: 2003
    ..Our experiments will establish how well the dynamics of ROS production predict cochlear injury, and whether progressive deafness genes may impair cochlear ROS regulation. ..
  31. Genetic Modulation of Noise Injury to the Cochlear Lateral Wall
    KEVIN OHLEMILLER; Fiscal Year: 2009
    ..The gene, and the processes in which it is involved, may affect the long-term stability of cochlear injury, and the accumulation of injury that may be diagnosed as presbycusis. ..
  32. Genetic Modulation of Noise Injury to the Cochlear Lateral Wall
    KEVIN OHLEMILLER; Fiscal Year: 2007
    ..The gene, and the processes in which it is involved, may affect the long-term stability of cochlear injury, and the accumulation of injury that may be diagnosed as presbycusis. ..
  33. Mechanisms of Alcohol Mediated Organ and Tissue Damage
    Gyongyi Szabo; Fiscal Year: 2005
    ..3. Increase the involvement of young investigators in the study of alcohol research. 4. Provide an educational forum to participants. ..
  34. INNER RETINAL NEURONS IN NORMAL AND DEGENERATING
    Enrica Strettoi; Fiscal Year: 2009
    ..This is very important to design mutation-independent therapies. ..
  35. Semaphorin-plexin signaling & vertebrate cell movement
    Jeremy Reiter; Fiscal Year: 2003
    ..By illuminating the role of plexin signaling in development, these studies may provide understanding into congenital disease as well as how cell movement is co-opted by pathologic processes such as tumor invasion and tumor angiogenesis. ..
  36. Spectrum of Autoimmune Gastrointestinal Dysmotility
    Vanda Lennon; Fiscal Year: 2009
    ..l.dysmotilities, and justify early consideration of immunomodulatory therapies. The proposed research also has high clinical relevance to cancer immunity. ..
  37. Proteomic Approach to Further Understanding the Role of*
    Alan Cantor; Fiscal Year: 2008
    ..These studies should provide important insights that will facilitate the design of novel therapies for MDS. ..
  38. Mast cell regulation of CD8+ T cell responses
    Melissa Brown; Fiscal Year: 2008
    ..2) To examine the influence of mast cells on dendritic cell maturation, migration and T cell stimulatory function in LCMV-infected mice. [unreadable] [unreadable]..
  39. Basal Ig Signaling and Receptor Editing
    Michael Farrar; Fiscal Year: 2009
    ..abstract_text> ..
  40. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
    ..There is not treatment that slows the relentless progression of the disease or that reverses it. In this application, we use an animal model to investigate methods to slow progression and reverse the disease. ..
  41. 2007 Aging, Biology of Gordon Conference
    LaDora Thompson; Fiscal Year: 2007
    ..We fully anticipate that progress in this field will pave the way for interventions and quality of life for the older adult. [unreadable] [unreadable] [unreadable] [unreadable]..
  42. Replacing an Animal Resource Facility Cage Washer.
    Kristen Drescher; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  43. Transmitter Repletion: Key to Phrenic-Diaphragm Function
    Erik van Lunteren; Fiscal Year: 2005
    ..These studies may lead to novel therapeutic approaches to respiratory muscle impairment and resulting hypercapnic respiratory failure for conditions which produce neuromuscular junction dysfunction. ..
  44. TRANSPORT MECHANISMS IN CORNEAL ENDOTHELIUM
    Jorge Fischbarg; Fiscal Year: 2004
    ..The understanding to be gained may provide insights on how to modulate fluid transport so as to offset endothelial dysfunction leading to the loss of normal vision. ..
  45. MECHANISMS OF CHONDROPROTECTION BY TGF-BETA
    Rosa Serra; Fiscal Year: 2004
    ..Data from the proposed experiments will provide insight into the mechanism of chondroprotection by TGF-B and potential strategies for preventing and treating damaged or arthritic cartilage. ..
  46. Sensory Coding Among Semicircular Canal Afferent Neurons
    LARRY HOFFMAN; Fiscal Year: 2004
    ..These experiments will reveal new insight regarding the fundamental organization of stimulus coding in this sensory system. ..
  47. NEURONAL FUNCTION IN CRANIOFACIAL DEVELOPMENT
    Stephanos Kyrkanides; Fiscal Year: 2004
    ..abstract_text> ..
  48. Genetics of Seizure Resistance: A Mutagenesis Strategy
    SCOTT BARABAN; Fiscal Year: 2004
    ..The results of this unique collaboration promise to provide new insights into the genetic factors that influence epilepsy, and will, perhaps, lead to a cure for this devastating neurological disorder. ..
  49. The Mouse as a Tool for Ear Research
    Kenneth Johnson; Fiscal Year: 2003
    ..abstract_text> ..
  50. ETHANOL, RETINOIDS, AND CONGENITAL HEART MALFORMATIONS
    Janee Gelineau van Waes; Fiscal Year: 2003
    ..abstract_text> ..
  51. Alveolization in Fibrillin-1 Defective Mice
    Enid Neptune; Fiscal Year: 2005
    ..abstract_text> ..
  52. The Mouse as an Instrument for Ear Research II
    Kenneth Johnson; Fiscal Year: 2005
    ..Ultimately, this meeting will bring students and established investigators, with varying expertise and experience, together to discuss their research findings, identify areas of common research interest and develop future directions. ..
  53. Proteomic Analysis of the Retina
    MONICA JABLONSKI; Fiscal Year: 2007
    ..These studies will also generate the framework for future project periods in which the precise molecular mechanisms and detailed pathways that control photoreceptor outer segment assembly will be determined. [unreadable] [unreadable]..
  54. Mast cell effects on islet cell destruction in NOD mice
    Melissa Brown; Fiscal Year: 2007
    ..To examine the consequencess of mast cell-deficiency on the development of spontaneous insulitis and diabetes. 3. To determine the sites of mast cell influence on diabetes development. [unreadable] [unreadable] [unreadable]..
  55. MOLECULAR PHYSIOLOGY OF BAND 3 LIKE PROTEINS OF KIDNEY
    Seth Alper; Fiscal Year: 2007
    ..5. Define aspects of transcriptional and translational regulation of AE gene products in kidney of mutant and parental mouse strains and in cultured kidney cells. ..
  56. Transport of neurotrophic cytokines after spinal cord injury
    Weihong Pan; Fiscal Year: 2007
    ..Understanding the mechanisms of cytokine transport at this regulatory interface would help in the design of new approaches to treat SCI. ..
  57. Complement inhibition in experimental autoimmune uveitis
    RUSSELL READ; Fiscal Year: 2006
    ..abstract_text> ..
  58. HSP25 and HSP20 Regulation in Skeletal Muscle Adapt
    KIMBERLY HUEY; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  59. The Role of Mast Cells in Lung Inflammation
    Joshua Boyce; Fiscal Year: 2006
    ..These studies, carried out in non-transformed hPrMC and hMC, have potential implications for the control of hMC distribution and effector function in asthma. ..
  60. Dopaminergic Influences on Brain Formation and Function
    GREGG STANWOOD; Fiscal Year: 2006
    ..abstract_text> ..
  61. LONG TERM COCAINE INDUCED CHANGES VIA DOPAMINE RECEPTORS
    Ming Xu; Fiscal Year: 2002
    ....