Genomes and Genes
Summary: A subfamily of the Muridae consisting of several genera including Gerbillus, Rhombomys, Tatera, Meriones, and Psammomys.
Publications265 found, 100 shown here
- Activation of beta-catenin by carcinogenic Helicobacter pyloriAime T Franco
Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
Proc Natl Acad Sci U S A 102:10646-51. 2005..cag- strains or uninfected persons. These results indicate that H. pylori-induced dysregulation of beta-catenin-dependent pathways may explain in part the augmentation in the risk of gastric cancer conferred by this pathogen...
- Localization of the cochlear amplifier in living sensitive earsTianying Ren
Oregon Hearing Research Center, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, United States of America
PLoS ONE 6:e20149. 2011..Although the cochlear amplifier is thought to be a local cellular process at an area basal to the response peak on the spiral basilar membrane, its location has not been demonstrated experimentally...
- A deep sequencing approach to comparatively analyze the transcriptome of lifecycle stages of the filarial worm, Brugia malayiYoung Jun Choi
Department of Pathobiological Sciences, University of Wisconsin Madison, Madison, Wisconsin, USA
PLoS Negl Trop Dis 5:e1409. 2011..Here we report a comprehensive genome-wide survey of the developmental transcriptome of the human filarial parasite Brugia malayi...
- Descending projections from the auditory cortex to the inferior colliculus in the gerbil, Meriones unguiculatusVictoria M Bajo
University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom
J Comp Neurol 486:101-16. 2005..Descending connections to the gerbil IC form a segregated system in which multiple descending channels originating from different neuronal subpopulations may modulate specific aspects of ascending auditory information...
- Longitudinal pattern of basilar membrane vibration in the sensitive cochleaTianying Ren
Oregon Hearing Research Center NRC 04, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239 3098, USA
Proc Natl Acad Sci U S A 99:17101-6. 2002....
- Dynamic interaction of Ih and IK-LVA during trains of synaptic potentials in principal neurons of the medial superior oliveSukant Khurana
Section of Neurobiology and Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712 0248, USA
J Neurosci 31:8936-47. 2011....
- Effects of ventral tegmental area stimulation on the acquisition and long-term retention of active avoidance learningAnton Ilango
Leibniz Institute for Neurobiology, Brenneckestrasse 6, D 39118 Magdeburg, Germany
Behav Brain Res 225:515-21. 2011..This may reflect frustration from the omission of expected reward. These results are relevant for optimizing brain stimulation to improve learning...
- Differential neuromodulation of acquisition and retrieval of avoidance learning by the lateral habenula and ventral tegmental areaJason Shumake
Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
J Neurosci 30:5876-83. 2010..These results demonstrate opponent roles of LHb and VTA during acquisition but not during retrieval of avoidance learning...
- The efficacy of erythropoietin and its analogues in animal stroke models: a meta-analysisJens Minnerup
Department of Neurology, University of Munster, Germany
Stroke 40:3113-20. 2009..We performed a meta-analysis to obtain an overall impression of the efficacy of EPO in published animal experimental stroke studies and for potential guidance of future clinical studies...
- Reverse propagation of sound in the gerbil cochleaTianying Ren
Oregon Hearing Research Center, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, NRC 04, Portland, Oregon 97239 3098, USA
Nat Neurosci 7:333-4. 2004..These results contradict the current theory and show that the ear emits sounds through the cochlear fluids as compression waves rather than along the basilar membrane as backward-traveling waves...
- The cochlear place-frequency map of the adult and developing Mongolian gerbilM Muller
Klinikum der J W Goethe Universitat, Zentrum der Physiologie, Frankfurt am Main, Germany
Hear Res 94:148-56. 1996..5 kHz. A shift in the frequency map occurs during cochlear maturation. The place-frequency map in subadult gerbils (18 days after birth) is shifted by a distance corresponding to an octave, at least for frequencies above 6 kHz...
- Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficitsQun Wang
Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA
J Neurosci Res 82:138-48. 2005..Together, these findings attribute the neuroprotective effect of curcumin against I/R-induced neuronal damage to its antioxidant capacity in reducing oxidative stress and the signaling cascade leading to apoptotic cell death...
- The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension testG B Varty
CNS Biological Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
Behav Pharmacol 14:87-95. 2003..These studies support both the utility of gerbils in behavioral pharmacology and the antidepressant potential of selective NK1 antagonists...
- Intestinal and hepatic cholesterol carriers in diabetic Psammomys obesusEmile Levy
Gastroenterology, Hepatology, and Nutrition Unit, Research Centre, Sainte Justine Hospital, 3175 Sainte Catherine Road, Montreal, Quebec, Canada
Endocrinology 151:958-70. 2010..Our findings show that the development in P. obesus with T2D modifies the whole intraenterocyte and hepatocyte machinery responsible for CHOL homeostasis...
- AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective propertiesSonia Carboni
Department of Pharmacology, Serono Pharmaceutical Research Institute, Geneva, Switzerland
J Pharmacol Exp Ther 310:25-32. 2004..v. infusion (0.6 mg/kg/h) was also observed in rats after focal cerebral ischemia. These data suggest that the use of JNK inhibitors such as AS601245 may be a relevant strategy in the therapy of ischemic insults...
- Increase of extracellular dopamine in prefrontal cortex of gerbils during acquisition of the avoidance strategy in the shuttle-boxH Stark
Leibniz Institute for Neurobiology, Magdeburg, Germany
Neurosci Lett 264:77-80. 1999..It was found that exclusively strategy formation correlated with high DA levels in mPFC...
- Y-like retinal ganglion cells innervate the dorsal raphe nucleus in the Mongolian gerbil (Meriones unguiculatus)Liju Luan
Department of Anatomy, School of Basic Medical Sciences, Peking University, Beijing, China
PLoS ONE 6:e18938. 2011..However little is known regarding the type of retinal ganglion cell (RGC) that innervates the DRN. We examined morphological characteristics and physiological properties of these DRN projecting ganglion cells...
- Multi-unit mapping of acoustic stimuli in gerbil inferior colliculusD M Harris
Yale University School of Medicine, New Haven, CT 06510, USA
Hear Res 108:145-56. 1997..This perspective of IC activity suggests potential processing mechanisms that are congruent with single-unit reconstructions...
- Stages of avoidance strategy formation in gerbils are correlated with dopaminergic transmission activityH Stark
Leibniz Institute for Neurobiology, P O B 1860, D 39118, Magdeburg, Germany
Eur J Pharmacol 405:263-75. 2000..The increase in dopamine in medial prefrontal cortex may be an indicator of the involvement of working memory principles in signal evaluation stages of conditioning...
- An atlas of the inferior colliculus of the gerbil in three dimensionsNell B Cant
Department of Neurobiology, Duke University Medical Center, P O Box 3209, Durham, NC 27710, USA
Hear Res 206:12-27. 2005..The atlas can be used for representation, comparison and correlation of neuroanatomical, neurophysiological, neurochemical and other data that can be spatially mapped in the inferior colliculus...
- Light deprivation induces depression-like behavior and suppresses neurogenesis in diurnal mongolian gerbil (Meriones unguiculatus)Benson Wui Man Lau
Department of Anatomy, The State Key Laboratory of Brain and Cognitive Sciences, Research Centre of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong, Pokfulam, Hong Kong SAR, PR China
Cell Transplant 20:871-81. 2011..Additionally, the current experiment may offer a model for exploring the relationship among daylight exposure, circadian cycles, depressive behavior, and the underlying mechanisms...
- Evolutionary systematics in African gerbilline rodents of the genus Gerbilliscus: inference from mitochondrial genesPaolo Colangelo
Dipartimento di Biologia Animale e dell Uomo, Universita di Roma La Sapienza, Via Borelli 50, 00161 Roma, Italy
Mol Phylogenet Evol 42:797-806. 2007..Our data seem to support the synonymy of the two taxa and suggest that Gerbillurus and Gerbilliscus lineages diverged from a common ancestor appeared in eastern Africa...
- Physical exercise enhances hepatic insulin signaling and inhibits phosphoenolpyruvate carboxykinase activity in diabetes-prone Psammomys obesusYuval Heled
Heller Institute of Medical Research and Pediatric Division, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Metabolism 53:836-41. 2004..We conclude that exercise improves in vivo hepatic insulin sensitivity in diabetes-prone Psammomys-obesus...
- Reverse wave propagation in the cochleaWenxuan He
Oregon Hearing Research Center, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, NRC04, Portland, OR 97239 3098, USA
Proc Natl Acad Sci U S A 105:2729-33. 2008..These data are in conflict with the backward- traveling-wave theory but are consistent with the idea that the emission comes out of the cochlea predominantly through compressional waves in the cochlear fluids...
- Rodents as reservoir hosts of cutaneous leishmaniasis in JordanE K Saliba
Department of Biological Sciences, University of Jordan, Amman
Ann Trop Med Parasitol 88:617-22. 1994..crassus, M. tristrami, Allactaga euphratica and Gerbillus spp.) yielded Leishmania parasites, confirming that P. obesus is the major reservoir host of cutaneous leishmaniasis in Jordan...
- Long-range effects of GABAergic inhibition in gerbil primary auditory cortexChristoph K Moeller
Experimental Otolaryngology, University of Erlangen Nuremberg, Waldstr 1, 91054 Erlangen, Germany
Eur J Neurosci 31:49-59. 2010..These data demonstrate the existence of long-range, inhibitory interactions within the gerbil AI, realized either by long-range inhibitory projections or by long-range excitatory projections to local inhibitory interneurons...
- Early unilateral auditory deprivation increases 2-deoxyglucose uptake in contralateral auditory cortex of juvenile Mongolian gerbilsI W Stuermer
Leibniz Institute for Neurobiology, Brenneckestr 6, P O Box 1860, 39008, Magdeburg, Germany
Hear Res 146:185-99. 2000..Distances between tone-induced 2-DG labeling in AI and AAF were increased in PAX, but smaller in ATR in the right compared to the left hemisphere, suggesting effects of atresia also on spatial relations in cortical tonotopic maps...
- Prolonged maturation of auditory perception and learning in gerbilsEmma C Sarro
Center for Neural Science, New York University, New York, New York 10003, USA
Dev Neurobiol 70:636-48. 2010..Furthermore, for several of the Juveniles with adult-like thresholds, AM detection deteriorated with repeated testing. Thus, immature perceptual skills in young animals were not associated with greater learning...
- Functional organization of auditory cortex in the Mongolian gerbil (Meriones unguiculatus). IV. Connections with anatomically characterized subcortical structuresE Budinger
Leibniz Institute for Neurobiology, Magdeburg, Germany
Eur J Neurosci 12:2452-74. 2000..The differences with respect to the existence and/or relative strengths of subcortical connections of the examined auditory cortical fields suggest a somewhat different function of each of these fields in auditory processing...
- Systematics and evolution of the subfamily Gerbillinae (Mammalia, Rodentia, Muridae)Pascale Chevret
Institut des Sciences de l Evolution de Montpellier, Laboratoire de Paléontologie, Paléobiologie, Phylogénie, UMR CNRS 5554, Universite de Montpellier II, Place Emile Bataillon, 34095 Montpellier, France
Mol Phylogenet Evol 35:674-88. 2005..The subfamily Gerbillinae is no exception as previous studies based on morphological, karyotypical, and allozyme characters are highly ..
- Explosive chromosome evolution and speciation in the gerbil genus Taterillus (Rodentia, Gerbillinae): a case of two new cryptic speciesG Dobigny
Laboratoire Mammifères et Oiseaux, Museum national d histoire naturelle, Paris, France
Cytogenet Genome Res 96:117-24. 2002..Possible factors responsible for the rapid karyotypic evolution and speciation in this West African gerbil complex are discussed...
- A quantitative analysis of psychometric functions for different auditory tasks in gerbilsOtto Gleich
ENT Department, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
Hear Res 220:27-37. 2006..In contrast, the steepness of the psychometric function is decreased in gerbils with impaired temporal resolution. We discuss these observations in the context of physiological data from young and old animals...
- Deafness disrupts chloride transporter function and inhibitory synaptic transmissionCarmen Vale
School of Medicine and Centro Regional de Investigaciones Biomedicas, University of Castilla La Mancha, Albacete 02071, Spain
J Neurosci 23:7516-24. 2003..This results in inhibitory synapses that are less able to block excitatory events...
- Empirical assessment of a threshold model for sylvatic plagueS Davis
Department of Biology, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
J R Soc Interface 4:649-57. 2007..Small sample size and local extinction received strong support and can account for most of the false positives. Host resistance received no support here but should be subject to more direct experimental testing...
- Hearing loss alters the subcellular distribution of presynaptic GAD and postsynaptic GABAA receptors in the auditory cortexEmma C Sarro
Center for Neural Science, New York University, New York, NY 10003, USA
Cereb Cortex 18:2855-67. 2008..Thus, both, the pre- and postsynaptic sides of inhibitory synapses that form upon pyramidal neurons of the ACx are regulated by neonatal auditory experience...
- Hearing loss prevents the maturation of GABAergic transmission in the auditory cortexVibhakar C Kotak
Center for Neural Science, New York University, New York, NY 10003, USA
Cereb Cortex 18:2098-108. 2008..Together, these data strongly suggest that the presynaptic release properties and expression of key postsynaptic GABA(A) receptor subunits are coregulated by hearing...
- Measurement of cochlear power gain in the sensitive gerbil earTianying Ren
Department of Otolaryngology and Head and Neck Surgery, Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon 97239, USA
Nat Commun 2:216. 2011..These results demonstrate experimentally that the cochlea amplifies soft sounds, offering insight into the mechanism responsible for the cochlear sensitivity...
- Age-dependent effect of hearing loss on cortical inhibitory synapse functionAnne E Takesian
Center for Neural Science, New York University, New York, New York, USA
J Neurophysiol 107:937-47. 2012..These long-lasting changes to inhibitory function may contribute to the auditory processing deficits associated with early hearing loss...
- Experience-dependent refinement of the inhibitory axons projecting to the medial superior oliveFlorian Werthat
Department Biologie II, Division of Neurobiology, LMU Munich, Grosshadernerstrasse 2, 82152 Martinsried, Germany
Dev Neurobiol 68:1454-62. 2008....
- Low rate of glucose 6-phosphate hydrolysis in liver cells is a physiological feature of non-diabetic wild sand rats (Psammomys obesus)E A Koceir
INSERM E 0221 Bioénergétique Fondamentale et Appliquée, Universite Joseph Fourier, Grenoble, France
Diabetes Metab 29:363-74. 2003..Psammomys obesus is a natural model of insulin resistance when fed a rodent laboratory chow...
- Asymmetric excitatory synaptic dynamics underlie interaural time difference processing in the auditory systemPablo E Jercog
Physics Department, New York University, New York, New York, United States of America
PLoS Biol 8:e1000406. 2010..We suggest, more generally, that the dependence of spike probability on rate of depolarization, as in these auditory neurons, provides a mechanism for temporal order discrimination between EPSPs...
- The isolated in vitro perfused spiral modiolar artery: pressure dependence of vasoconstrictionP Wangemann
Cell Physiology Laboratory, Boys Town National Research Hospital, Omaha, NE 68131, USA
Hear Res 115:113-8. 1998....
- Helicobacter pylori cag-type IV secretion system facilitates corpus colonization to induce precancerous conditions in Mongolian gerbilsGabriele Rieder
Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Ludwig Maximilians University, Munich, Germany
Gastroenterology 128:1229-42. 2005..The role of the Helicobacter pylori type IV secretion system (T4SS) for pathogenesis in the Mongolian gerbil model was explored...
- Mechanoelectric transduction of adult inner hair cellsShuping Jia
Hair Cell Biophysics Laboratory, Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
J Neurosci 27:1006-14. 2007..There is a phase lead of IHC transducer currents relative to sinusoidal BM displacement, reflecting viscoelastic coupling of their cilia and their adaptation process...
- Comparison of two genetically related Entamoeba histolytica cell lines derived from the same isolate with different pathogenic propertiesLaura Biller
Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
Proteomics 9:4107-20. 2009..Summarized, a defined set of different proteins could be identified between cell lines A and B. These molecules may have an important role in amoeba pathogenicity...
- Interaction of excitation and inhibition in anteroventral cochlear nucleus neurons that receive large endbulb synaptic endingsCornelia Kopp-Scheinpflug
Department of Neurobiology, University of Leipzig, 04103 Leipzig, Germany
J Neurosci 22:11004-18. 2002..The inhibition specifically affects the processing of the spectral, temporal, and intensity cues of acoustic signals...
- Animal models of focal and global cerebral ischemiaRichard J Traystman
Department of Anesthesiology Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
ILAR J 44:85-95. 2003..This review summarizes many (but not all) small and large animal models of focal and global cerebral ischemia and discusses their advantages and disadvantages...
- Global versus local processing of frequency-modulated tones in gerbils: an animal model of lateralized auditory cortex functionsWolfram Wetzel
Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
Proc Natl Acad Sci U S A 105:6753-8. 2008..The left AC, by using local cues, discriminates gap durations and determines FM direction only when additional segmental information is available...
- Dynamics of Leishmania infection rates in Rhombomys opimus (Rodentia: Gerbillinae) population of an endemic focus of zoonotic cutaneous leishmaniasis in IranA A Akhavan
Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Bull Soc Pathol Exot 103:84-9. 2010..In this study, seasonal variation of natural infection with Leishmania parasites in Rhombomys opimus (Rodentia: Gerbillinae) population of an endemic focus of ZCL in Iran was monitored...
- Two-tone distortion at different longitudinal locations on the basilar membraneWenxuan He
Oregon Hearing Research Center, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, Portland, OR 97239 3098, USA, and Department of Otolaryngology of First Affiliated Hospital, Xi an, Shaanxi 710061, PR China
Hear Res 228:112-22. 2007..The data indicate that the emission travels along the BM from base to apex as a forward traveling wave, and no backward traveling wave was detected under the current experimental conditions...
- Diurnal variation of c-Fos expression in subdivisions of the dorsal raphe nucleus of the Mongolian gerbil (Meriones unguiculatus)S Janusonis
Neuroscience and Behavior Program, University of Massachusetts, Amherst, Massachusetts 01003, USA
J Comp Neurol 440:31-42. 2001..These results suggest that DRN subdivisions may differ functionally with regard to the diurnal cycle, and that these differences may be reflected in the activity of nonserotonergic cells in the DRN...
- Multisensory processing via early cortical stages: Connections of the primary auditory cortical field with other sensory systemsE Budinger
Leibniz Institute for Neurobiology, Department of Auditory Learning and Speech, Brenneckestrasse 6, D 39118 Magdeburg, Germany
Neuroscience 143:1065-83. 2006..the somatosensory and olfactory ones) multisensory information is probably also processed in these cortices. This suggests more generally, that primary sensory cortices may not be unimodal...
- Gender differences in myogenic regulation along the vascular tree of the gerbil cochleaKatrin Reimann
Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas, United States of America
PLoS ONE 6:e25659. 2011..Male spiral modiolar arteries responded more to L-NNA than female spiral modiolar arteries, suggesting that NO-dependent mechanisms play a bigger role in the myogenic regulation of male than female gerbil cochlear vessels...
- Presynaptic GABA(B) receptors regulate experience-dependent development of inhibitory short-term plasticityAnne E Takesian
Center for Neural Science, New York University, New York, New York 10003, USA
J Neurosci 30:2716-27. 2010..This novel synaptic mechanism may support the emergence of mature temporal processing in the auditory cortex...
- Reverse cochlear propagation in the intact cochlea of the gerbil: evidence for slow traveling wavesSebastiaan W F Meenderink
Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
J Neurophysiol 103:1448-55. 2010..These delays remained significant after compensating for middle-ear delay. The results contradict the hypothesis that the reverse propagation of emissions is exclusively by direct pressure waves...
- Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic isletsKathrin Maedler
Division of Endocrinology and Diabetes, University Hospital, Zurich, Switzerland
J Clin Invest 110:851-60. 2002..These findings implicate an inflammatory process in the pathogenesis of glucotoxicity in type 2 diabetes and identify the IL-1beta/NF-kappaB pathway as a target to preserve beta cell mass and function in this condition...
- The effect of Helicobacter felis and Helicobacter bizzozeronii on the gastric mucosa in Mongolian gerbils: a sequential pathological studyM de Bock
Departments of Pathology, Bacteriology and Avian Diseases, Faculty of Medicine, Ghent University, Belgium
J Comp Pathol 135:226-36. 2006..The mechanism by which H. felis induces PC necrosis and apoptosis remains unclear. The observed flagellar contact and NF-kappaB activation may play an important role in H. felis-associated inflammation...
- Late calcium EDTA rescues hippocampal CA1 neurons from global ischemia-induced deathAgata Calderone
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 24:9903-13. 2004..The finding of neuroprotection by late CaEDTA administration has striking implications for intervention in the delayed neuronal death associated with global ischemia...
- Distortion product otoacoustic emissions evoked by tone complexesSebastiaan W F Meenderink
Department of Neuroscience, Erasmus MC, Dr Molewaterplein 50, Rotterdam, 3015 GE, The Netherlands
J Assoc Res Otolaryngol 12:29-44. 2011..We analyzed the relation between multitone-evoked DPOAEs and DPOAEs evoked by tone pairs, and explored the new degrees of freedom offered by the multitone paradigm...
- Mitochondrial metabolism reveals a functional architecture in intact islets of Langerhans from normal and diabetic Psammomys obesusS M Katzman
Dept of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA
Am J Physiol Endocrinol Metab 287:E1090-9. 2004..These data support the hypothesis that glucose enhances metabolic coupling in normal islets and that the dampening of oscillatory insulin secretion in NIDDM may result from disrupted metabolic coupling...
- In vivo protein transduction: biologically active intact pep-1-superoxide dismutase fusion protein efficiently protects against ischemic insultWon Sik Eum
Department of Genetic Engineering, Research Institute for Bioscience and Biotechnology, Hallym University, 1 1 Okchon Dong, Chunchon, Kangwon Do, Korea, 200 702, Korea
Free Radic Biol Med 37:1656-69. 2004..These results suggest that the biologically active intact forms of PEP-1-SOD provide a more efficient strategy for therapeutic delivery in various human diseases related to this antioxidant enzyme or to ROS, including stroke...
- Exploiting development to evaluate auditory encoding of amplitude modulationMerri J Rosen
Department of Anatomy and Neurobiology, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272, USA
J Neurosci 30:15509-20. 2010..However, if sAM detection is based on a population response, then immature detection thresholds are more likely caused by an inadequate sensory representation...
- Intracellularly labeled fusiform cells in dorsal cochlear nucleus of the gerbil. II. Comparison of physiology and anatomyKenneth E Hancock
Department of Biomedical Engineering and Hearing Research Center, Boston University, Boston, Massachusetts 02215 2407, USA
J Neurophysiol 87:2520-30. 2002..Such trends indicate that neighboring fusiform cells are endowed with different signal processing capabilities...
- Endothelin-1-induced vasospasms of spiral modiolar artery are mediated by rho-kinase-induced Ca(2+) sensitization of contractile apparatus and reversed by calcitonin gene-related PeptideElias Q Scherer
Anatomy and Physiology Department, Kansas State University, Manhattan, KS 66506, USA
Stroke 33:2965-71. 2002....
- Normal hearing is required for the emergence of long-lasting inhibitory potentiation in cortexHan Xu
Center for Neural Science and Department of Biology, New York University, New York, New York 10003, USA
J Neurosci 30:331-41. 2010..These data indicate that early experience is necessary for the normal development of BDNF-mediated long-lasting inhibitory potentiation, which may be associated with perceptual deficits at later ages...
- Rapid loss of motility of Helicobacter pylori in the gastric lumen in vivoSören Schreiber
Institut fur Physiologie, MA 2 149, Ruhr Universitaet Bochum, Universitaetsstrasse 150, D 44801 Bochum, Germany
Infect Immun 73:1584-9. 2005..pylori in the gastric chymus to only a few minutes by rapidly inhibiting active motility. It is therefore likely that this short period of resistance in the gastric lumen is one of the most critical phases of Helicobacter infection...
- Stage- and gender-specific proteomic analysis of Brugia malayi excretory-secretory productsYovany Moreno
Institute of Parasitology, McGill University, Ste Anne de Bellevue, Quebec, Canada
PLoS Negl Trop Dis 2:e326. 2008..Little is known about the composition and variability of products released at different developmental stages and their contribution to parasite survival and progression of the infection...
- Antagonists of group I metabotropic glutamate receptors do not inhibit induction of ischemic tolerance in gerbil hippocampusMalgorzata Duszczyk
Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Street, 02 106 Warsaw, Poland
Neurochem Int 48:478-84. 2006..Both antagonists did not inhibit the induction of ischemic tolerance. Thus, our data indicate that group I metabotropic glutamate receptors do not play an essential role in the induction of ischemic tolerance...
- Differential effects of iontophoretic application of the GABAA-antagonists bicuculline and gabazine on tone-evoked local field potentials in primary auditory cortex: interaction with ketamine anesthesiaSimone Kurt
Institute for Neurobiology, University of Ulm, Albert Einstein Allee 11, Ulm, Germany
Brain Res 1220:58-69. 2008..We conclude from the data presented that the main functional role of GABA(A)-mediated inhibition in auditory cortex is to (1) prevent over-excitation (seizures) of cortical networks and (2) to speed up cortical processing...
- Waves on Reissner's membrane: a mechanism for the propagation of otoacoustic emissions from the cochleaTobias Reichenbach
Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065 6399, USA
Cell Rep 1:374-84. 2012..The results are in accord with the theory and thus support a role for Reissner's membrane in otoacoustic emissions...
- Unusually extensive karyotype reorganization in four congeneric Gerbillus species (Muridae: Gerbillinae)V M Aniskin
Severtsov Institut of Ecology and Evolution, Russian Academy of Sciences, Moscow, Russia
Cytogenet Genome Res 112:131-40. 2006..Based on the chromosomal data obtained here, the systematic and geographic implications for these North African species are also discussed...
- Simultaneous measurements of ossicular velocity and intracochlear pressure leading to the cochlear input impedance in gerbilO de La Rochefoucauld
Department of Otolaryngology, Head and Neck Surgery, Columbia University, 630 West 168th Street, New York, NY, 10032, USA
J Assoc Res Otolaryngol 9:161-77. 2008..The observed wide-band intracochlear pressure and power flow are consistent with the wide-band audiogram of the gerbil...
- Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responsesD A Israel
Division of Gastroenterology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Clin Invest 107:611-20. 2001..Use of an H pylori whole genome microarray is an effective method to identify differences in gene content between H. pylori strains that induce distinct pathological outcomes in a rodent model of H. pylori infection...
- Distinguishing cochlear pathophysiology in 4-aminopyridine and furosemide treated ears using a nonlinear systems identification techniqueL Bian
Hearing and Speech Department, University of Kansas Medical Center, Kansas City 66160, USA
J Acoust Soc Am 109:671-85. 2001..It is concluded that the NLID technique is sensitive and specific to alterations in the cochlear physiology...
- Reliability of synaptic transmission at the synapses of Held in vivo under acoustic stimulationBernhard Englitz
Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany
PLoS ONE 4:e7014. 2009..In vivo this discrepancy could be due to the difficulty in identifying failures of transmission...
- Multilinear models of single cell responses in the medial nucleus of the trapezoid bodyB Englitz
Max Planck Institute for Mathematics in the Sciences, Inselstrasse 22, Leipzig, Germany
Network 21:91-124. 2010..In conclusion, the context model provides a rich and still interpretable extension over many previous phenomenological models for modeling responses in the auditory brainstem at submillisecond resolution...
- The sources of electrically evoked otoacoustic emissionsYuan Zou
Oregon Hearing Research Center, Department of Otolaryngology, Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
Hear Res 180:91-100. 2003..One part of this energy propagates directly to the ear canal, forming the SDC, and the other part propagates to its CF place and is reflected from there to the ear canal, forming the LDC...
- The spatial pattern of cochlear amplificationJonathan A N Fisher
Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
Neuron 76:989-97. 2012..These results reveal the locus of amplification in cochlear traveling waves and connect the characteristics of normal hearing to molecular forces...
- Tadalafil improves short-term memory by suppressing ischemia-induced apoptosis of hippocampal neuronal cells in gerbilsIl Gyu Ko
Department of Physiology, College of Medicine, Kyung Hee University, 1 Hoigi dong, Dongdaemoon gu, Seoul 130 701, Republic of Korea
Pharmacol Biochem Behav 91:629-35. 2009..We showed that tadalafil can overcome ischemia-induced apoptotic neuronal cell death, thus facilitates recovery following ischemic cerebral injury...
- Gastric mucosal changes induced by long term infection with Helicobacter pylori in Mongolian gerbils: effects of bacteria eradicationY Keto
Department of Applied Pharmacology, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8414, Japan
J Physiol Paris 95:429-36. 2001..It was concluded that early eradication of H. pylori infection with drug therapy can prevent severe gastric mucosal changes, to include adenocarcinomas, in Mongolian gerbils...
- Effects of auditory stimulus context on the representation of frequency in the gerbil inferior colliculusB J Malone
Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA
J Neurophysiol 86:1113-30. 2001..The demonstration that conditioning effects reflect sensitivity to spectral as well as spatial stimulus contrast has broad implications for the processing of a wide range of dynamic acoustic signals and sound sequences...
- Gerbil middle-ear sound transmission from 100 Hz to 60 kHzMichael E Ravicz
Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, Massachusetts 02114, USA
J Acoust Soc Am 124:363-80. 2008....
- Different expression patterns of Ngb and EPOR in the cerebral cortex and hippocampus revealed distinctive therapeutic effects of intranasal delivery of Neuro-EPO for ischemic insults to the gerbil brainYan Gao
Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, PR China
J Histochem Cytochem 59:214-27. 2011..The different expression patterns of Ngb and EPOR is probably due to ischemic tolerance in the cerebral cortex and ischemic sensitivity in the hippocampus...
- Systematics and phylogeny of West African gerbils of the genus Gerbilliscus (Muridae: Gerbillinae) inferred from comparative G- and C-banding chromosomal analysesV Volobouev
Museum national d histoire naturelle, UMR 5202 Origine, Structure et Evolution de la Biodiversité, Paris, France
Cytogenet Genome Res 116:269-81. 2007....
- Spiking neurons learning phase delays: how mammals may develop auditory time-difference sensitivityChristian Leibold
Physik Department, Technische Universitat Munchen, 85747 Garching bei Munchen, Germany
Phys Rev Lett 94:168102. 2005..By means of a biophysical model we show how spike-timing-dependent synaptic learning explains precise interplay of excitation and inhibition and, hence, accounts for a physical realization of a phase delay...
- Functional correlates of characteristic frequency in single cochlear nerve fibers of the Mongolian gerbilK K Ohlemiller
Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208
J Comp Physiol A 167:329-38. 1990..These results are compared with similar data from other species and discussed in terms of recent studies on sound communication and cochlear anatomy in gerbils...
- Population coding of interaural time differences in gerbils and barn owlsNicholas A Lesica
Division of Neurobiology, Department Biology II, Ludwig Maximilians University Munich, Martinsried, Germany
J Neurosci 30:11696-702. 2010..Together, our results support the idea that, unlike the avian brain, the mammalian brain represents ITDs in the overall activity of a homogenous population of neurons within each hemisphere...
- Decrease of PKC precedes other cellular signs of calpain activation in area CA1 of the hippocampus after transient cerebral ischemiaM Ziemka-Nałecz
Laboratory of Molecular Neuropathology, Department of Neurochemistry, Medical Research Centre, Warsaw, Poland
Neurochem Int 42:205-14. 2003....
- Enhancement of ITD coding within the initial stages of the auditory pathwayMichael Pecka
Department of Biology II, Ludwig Maximilians University Munich, Martinsried, Germany
J Neurophysiol 103:38-46. 2010....
- Retinal afferents to the dorsal raphe nucleus in rats and Mongolian gerbilsK V Fite
Neuroscience and Behavior Program, University of Massachusetts, Amherst, Massachusetts 01003, USA
J Comp Neurol 414:469-84. 1999..Major differences observed in the extent and configuration of the retinal-DRN pathway may be related to the diurnal/crepuscular vs. nocturnal habits of these two species...
- Retinal ganglion cells projecting to the dorsal raphe and lateral geniculate complex in Mongolian gerbilsKatherine V Fite
Neuroscience and Behavior Program, Tobin Hall, University of Massachusetts, Amherst, MA 01003, USA
Brain Res 973:146-50. 2003..DL RGC soma diameters fell primarily within the mid-to-upper size range of all three distributions. DL RGCs may provide information to both nuclei concerning comparable aspects of light and visual stimulation via collateralized axons...
- Evidence for multiple DPOAE components based upon group delay of the 2f(1)-f(2) distortion in the gerbilM Faulstich
Zoologisches Institut der Universität München, Luisenstr 14, 80333, Munich, Germany
Hear Res 140:99-110. 2000..5 kHz but failed to reflect the sensitivity for lower frequencies. This may be a consequence of more linear frequency processing in the apex...
- Ca2+-dependence and nifedipine-sensitivity of vascular tone and contractility in the isolated superfused spiral modiolar artery in vitroP Wangemann
Cell Physiology Laboratory, Boys Town National Research Hospital, Omaha, NE 68131, USA
Hear Res 118:90-100. 1998..Further, the data suggest that cytosolic Ca2+ stores, if present in the spiral modiolar artery, are of limited capacity compared to other vessels...
- Spectral composition of concurrent noise affects neuronal sensitivity to interaural time differences of tones in the dorsal nucleus of the lateral lemniscusIda Siveke
Division of Neurobiology, Department Biology II, Ludwig Maximilians Universitat Munchen, Germany
J Neurophysiol 98:2705-15. 2007..A simple simulation corroborates this interpretation. Taken together, these findings suggest that the spectral composition of a concurrent sound strongly influences the spatial processing of ITD-sensitive DNLL neurons...
- Cochlear mechanisms of frequency and intensity coding. I. The place code for pitchM Chatterjee
Institute for Sensory Research, Syracuse University, NY 13244, USA
Hear Res 111:65-75. 1997..On the other hand, the recordings indicate that the apical cutoff of the spatial excitation pattern is SPL-independent. We conclude, therefore, that the place theory of pitch perception must be abandoned or at least modified...
- Evolution of rRNA gene clusters and telomeric repeats during explosive genome repatterning in TATERILLUS X (Rodentia, Gerbillinae)G Dobigny
Laboratoire Origine, Structure et Evolution de la Biodiversité, Museum national d histoire naturelle, Paris, France
Cytogenet Genome Res 103:94-103. 2003..and telomeric repeats was performed using single and double FISH in the Taterillus genus (Rodentia, Muridae, Gerbillinae). Taterillus was previously demonstrated to have undergone a very recent and extensive chromosomal evolution...
- Intensity-dependent peak shift in cochlear transfer functions at the cellular level, its elimination by sound exposure, and its possible underlying mechanismsM Zhang
Institute of Sensory Research, Syracuse University, NY 13244 5290, USA
Hear Res 96:46-58. 1996..Consequently, the feedback, when present, must shift the best frequency upward...
- Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemiaClaudio Hetz
Serono Pharmaceutical Research Institute, 14 Chemin des Aulx, CH 1228 Plan les Ouates, Geneva, Switzerland
J Biol Chem 280:42960-70. 2005..The protective effect in the animal model correlated with decreased cytochrome c release in the infarcted area. This is the first demonstration that Bax channel activity is required in apoptosis...
- Helicobacter pylori cag-Pathogenicity island-dependent early immunological response triggers later precancerous gastric changes in Mongolian gerbilsTobias Wiedemann
Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University, Munich, Germany
PLoS ONE 4:e4754. 2009..The early cag-PAI-dependent immunological response triggers later physiological and histopathological alterations towards gastric malignancies...
- Synaptic transmission at the calyx of Held under in vivo like activity levelsJoachim Hermann
Ludwig Maximilians University, Munich, Germany
J Neurophysiol 98:807-20. 2007....
- Synaptic transmission and short-term plasticity at the calyx of Held synapse revealed by multielectrode array recordingsMartin D Haustein
Faculty of Biosciences, Pharmacy and Psychology, University of Leipzig, Leipzig, Germany
J Neurosci Methods 174:227-36. 2008..Moreover, MEAs enable convenient analysis of activity-dependent depression and modulation of neuronal activity by glycine and GABA at later developmental stages not accessible to patch recordings...
- CDP-choline: Mechanisms in Cerebral IschemiaRAO ADIBHATLA; Fiscal Year: 2006..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..
- DEVELOPMENTAL STUDIES OF COCHLEAR MECHANICSDavid Mills; Fiscal Year: 2003..abstract_text> ..
- Studies of cochlear mechanics: otoacoustic emissionsTianying Ren; Fiscal Year: 2005..abstract_text> ..
- NEUROANATOMY OF THE AUDITORY SYSTEMNell B Cant; Fiscal Year: 2010..Detailed understanding of these connections will contribute to the development of rational, testable hypotheses about auditory function in both health and disease. ..
- QUANTITATIVE MORPHOPHYSIOLOGY OF VESTIBULAR AFFERENTSGOLDA KEVETTER; Fiscal Year: 2004..This could prove important for treatment of patients with vestibular disorders, such as those suffering with Meniere's disease or even normal aging. ..
- Exploring otoacoustic emissions with intracochlear pressure measurementsWei Dong; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Optical stimulation of the auditory nerveAGNELLA IZZO; Fiscal Year: 2006..Aim (2) will utilize the variable-wavelength, variable-repetition rate Free Electron Laser to demonstrate optical stimulation of auditory neurons at high repetition rates. [unreadable] [unreadable] [unreadable]..
- Cell survival and cell death in the auditory nerveHainan Lang; Fiscal Year: 2008..abstract_text> ..
- Physiological Studies of Age-Related Hearing LossRICHARD SCHMIEDT; Fiscal Year: 2007..Taken together, the three aims explore the major causes and effects of metabolic presbyacusis and have direct application to future interventions to help restore age-related hearing loss. [unreadable] [unreadable]..
- Investigating the nature of prestin-associated proteinsJing Zheng; Fiscal Year: 2007..This knowledge may make it possible to manipulate OHC function for therapeutic purposes. ..
- Transcription Factors & Inflammatory Mediators in StrokeRaghu Vemuganti; Fiscal Year: 2007..The ultimate goal is to define the role of SOCS-3/STAT-3 in post-ischemic cerebral inflammation. ..
- Cardiac Function and Cardiac iron (T2*) in ThalassemiaJohn Wood; Fiscal Year: 2007..These studies will provide the necessary groundwork for longitudinal studies of cardiac iron load on cardiac performance in thalassemia patients. ..
- The Pharmacology Education PartnershipROCHELLE SCHWARTZ BLOOM; Fiscal Year: 2006..Based on our previous study, the students learn science better too! ..
- COMPARATIVE SPEECH PERCEPTIONJOAN SINNOTT; Fiscal Year: 2007..As far as health-relatedness of the overall project, "monkey-model" data may contribute to the verification of currently proposed models of human infant speech perception development. ..
- Role of Egr-1 in post-stroke inflammation & brain damageRaghu Vemuganti; Fiscal Year: 2009..The ultimate goal is to define the role of EgM and its regulators to develop therapies to control cerebral inflammation at the level of transcription. ..
- COCHLEAR NERVE DEVELOPMENTSTEPHEN ECHTELER; Fiscal Year: 2001..It is crucial to understand the cellular interactions that form and maintain these sensorineural elements if effective biological strategies are to be devised for their protection or repair. ..
- Hearing loss affects synaptic balance in auditory cortexDan Sanes; Fiscal Year: 2009..Together, the results are significant for understanding at a cellular level how auditory processing is influenced by mild to severe deafness, and how we might compensate for these deficits. ..
- Central Auditory system Effects of Auditory DeprivationDebara Tucci; Fiscal Year: 2006..We hypothesize that the potential for reversibility will depend upon the type and severity of the structural modification induced by conductive impairment, and the developmental stage of the animal at the time of the insult. ..
- CLINICAL MEASURES OF AUDITORY LINEAR/NONLINEAR PROCESSESMARK CHERTOFF; Fiscal Year: 2004..abstract_text> ..
- NEURAL AND ENDOCRINE REGULATION OF BRAIN AND BEHAVIORRichard Wurtman; Fiscal Year: 2003..abstract_text> ..
- Building the researchers in audiology and hearingDebara Tucci; Fiscal Year: 2003....
- Circadian Rhythms: Photic Sensitivity and BehaviorRoberto Refinetti; Fiscal Year: 2003..abstract_text> ..
- TRANSIENT CEREBRAL ISCHEMIA & GABA NEUROTRANSMISSIONROCHELLE SCHWARTZ BLOOM; Fiscal Year: 2004..Understanding how ischemic insults affect inhibitory neuronal transmission and how specific populations of neurons die will help us to identify new treatment strategies to prevent ischemia-induced neuronal death in humans. ..
- In Vitro Analysis of Embryonic Inner Ear CellsLYNNE BIANCHI; Fiscal Year: 2002..Together, these experiments will provide information regarding the mechanisms used for organizing normal auditory and vestibular epithelia and may provide insight into means of treating congenital anomalies of the inner ear...
- PSYCHOPHARMACOLOGICAL EFFECTS OF EXOGENOUS CHOLINERichard Wurtman; Fiscal Year: 2008..abstract_text> ..
- The Role of Corticotropin-Releasing Factor in Primate Maternal BehaviorWendy Saltzman; Fiscal Year: 2007..Ultimately, this research will have implications for the understanding and treatment of stress-related psychopathology in women. [unreadable] [unreadable] [unreadable]..
- DEVELOPMENT OF INHIBITATION IN THE AUDITORY SYSTEMDan Sanes; Fiscal Year: 2004..abstract_text> ..
- CYTOSOLIC REGULATION OF INNER EAR ION TRANSPORTA PHILINE WANGEMANN; Fiscal Year: 2007..first, middle) The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
- GABA: EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUSAnthony van den Pol; Fiscal Year: 2008..GABA's excitatory actions during development are widespread throughout the brain. Thus, what we learn from our experiments on hypothalamic neurons should have general applicability to other CNS neurons. ..
- Genetics of Cryptosporidium parvumGiovanni Widmer; Fiscal Year: 2010..Such valleys will be identified by quantitatively genotyping a selected and a control progeny population with a panel of single nucleotide polymorphisms. ..
- Nontypeable Haemophilus influenzae & host cell signalingWILLIAM SWORDS; Fiscal Year: 2003..abstract_text> ..
- STRUCTURE/FUNCTION RELATIONS OF COCHLEAR NUCLEUS NEURONSHERBERT VOIGT; Fiscal Year: 2001....
- Hypocretin NeuronsAnthony N van den Pol; Fiscal Year: 2010..Understanding the role of the endogenous opioid in hypocretin cells should also facilitate the understanding and treatment of narcolepsy. ..
- Functional Genomics of Cryptosporidium parvumGiovanni Widmer; Fiscal Year: 2007..parvum. A comparison of the host cell response to C. parvum type 1 and type 2 will be performed to probe the molecular basis of the observed difference in virulence between types. ..
- Genetics of Cryptosporidium parvumGiovanni Widmer; Fiscal Year: 2008..Mutations will be mapped to the genome of C. hominis, C. muris and more distantly related apicomplexan to identify those most likely to affect protein function or transcriptional regulation. ..
- GABA Receptors in the Acquisition and Extinction of FearScott Heldt; Fiscal Year: 2006..unreadable] [unreadable]..
- PHOTOPERIODIC CONTROL OF OBESITYTimothy Bartness; Fiscal Year: 2008..RESEARCH GRANT TABLE OF CONTENTS Page Numbers 1 Face Page .................................................................................................................................................. Description, ..
- ASM Conference on PasteurellaceaeWILLIAM SWORDS; Fiscal Year: 2008..Thus, this meeting bridges multiple disciplines to provide opportunity for exchange and development of ideas. [unreadable] [unreadable] [unreadable]..
- Neurotransmission at the vestibular calyx synapseKATHERINE RENNIE; Fiscal Year: 2007..The combination of experimental & modeling approaches will elucidate how sensory information is transformed by HC1 & converted into a neural code by their afferents. ..
- Ion Transport Mechanisms in Type I FibrocytesZhijun Shen; Fiscal Year: 2003....
- Role of vestibular cortex in SCD subjects using fMRIGalen Kaufman; Fiscal Year: 2004..abstract_text> ..
- MECHANISMS OF SEXUAL DIFFERENTIATION IN NEURAL SYSTEMSNANCY FORGER; Fiscal Year: 2004....
- Nonhematopoietic Developmental Functions of EPOSandra Juul; Fiscal Year: 2004..We feel these experiments will provide important specific insights into the regulation of neonatal intestinal growth and injury. ..
- Epo as a Rescue Agent for Perinatal Hypoxia-IschemiaSandra Juul; Fiscal Year: 2004....
- FUNCTIONAL CORRELATES OF MOLECULAR MARKERS OF ADAPTATIONGalen Kaufman; Fiscal Year: 2004..These findings could provide evidence regarding how the brain develops sensorimotor sets appropriate for two environments. ..
- MECHANOELECTRICAL TRANSDUCTION IN ADULT OUTER HAIR CELLSDavid He; Fiscal Year: 2004....
- Generation of antigen specific regulatory T cellsChenthamarakshan Vasu; Fiscal Year: 2005..In aim-l, we will test the efficacy of BiAb in inducing regulatory T cells in vivo and in vitro. In aim-2, we will test the ability of these regulatory T cells in down modulating EAT and CIA. ..
- Novel therapeutics for chronic painPaul Wood; Fiscal Year: 2005....
- Genetic Transformation of Cryptosporidium parvumGiovanni Widmer; Fiscal Year: 2005..Approach: Transformation by electroporation of sporozoites with GFP expression plasmids; detection of transformants in cell culture by fluorescent microscopy, anti-GFP antibodies, or reverse-transcriptase PCR. ..
- Mycobacterium tuberculosis in vivo gene expressionJames Graham; Fiscal Year: 2005..Understanding the roles of such differentially expressed genes will further define host-pathogen interactions in human disease, and allow development of new tools to reduce the enormous global impact of tuberculosis on mankind. ..
- Low Optical Coherence Interferometry for the CochleaAlfred Nuttall; Fiscal Year: 2007..abstract_text> ..
- VESTIBULAR NUCLEUS ACTIVITY IN VESTIBULAR COMPENSATIONSHAWN NEWLANDS; Fiscal Year: 2003..abstract_text> ..
- Mechanics of Hearing Meeting 2005Alfred Nuttall; Fiscal Year: 2005..In addition, attendees will receive information and experience in how to be proactive in the area of public education for hearing science. ..
- THE MECHANISM OF OUTER HAIR CELL MOTILITYRichard Hallworth; Fiscal Year: 2004..In Aim 3, the role of the cortex, a subcellular structure in OHC stiffness will be determined using a developmental approach. ..
- Development of 13C-retinol isotope dilution techniquesSherry Tanumihardjo; Fiscal Year: 2006..abstract_text> ..
- COCHLEAR VULNERABILITY/REACTIVE OXYGEN SPECIESKEVIN OHLEMILLER; Fiscal Year: 2003..Our experiments will establish how well the dynamics of ROS production predict cochlear injury, and whether progressive deafness genes may impair cochlear ROS regulation. ..
- PRESYNAPTIC LONG-TERM SYNAPTIC DEPRESSIONPATRIC STANTON; Fiscal Year: 2008..The long-term regulation of transmitter release has far-reaching importance to normal synaptic processing dynamics, and controlling pathologic glutamate release during injury or disease. ..
- Genetic Modulation of Noise Injury to the Cochlear Lateral WallKEVIN OHLEMILLER; Fiscal Year: 2009..The gene, and the processes in which it is involved, may affect the long-term stability of cochlear injury, and the accumulation of injury that may be diagnosed as presbycusis. ..
- Genetic Modulation of Noise Injury to the Cochlear Lateral WallKEVIN OHLEMILLER; Fiscal Year: 2007..The gene, and the processes in which it is involved, may affect the long-term stability of cochlear injury, and the accumulation of injury that may be diagnosed as presbycusis. ..
- Microfilarial enhancement of Dengue transmissionJEFFERSON VAUGHAN; Fiscal Year: 2002....