gerbillinae

Summary

Summary: A subfamily of the Muridae consisting of several genera including Gerbillus, Rhombomys, Tatera, Meriones, and Psammomys.

Top Publications

  1. pmc Activation of beta-catenin by carcinogenic Helicobacter pylori
    Aime T Franco
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    Proc Natl Acad Sci U S A 102:10646-51. 2005
  2. pmc Localization of the cochlear amplifier in living sensitive ears
    Tianying Ren
    Oregon Hearing Research Center, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 6:e20149. 2011
  3. pmc A deep sequencing approach to comparatively analyze the transcriptome of lifecycle stages of the filarial worm, Brugia malayi
    Young Jun Choi
    Department of Pathobiological Sciences, University of Wisconsin Madison, Madison, Wisconsin, USA
    PLoS Negl Trop Dis 5:e1409. 2011
  4. ncbi Descending projections from the auditory cortex to the inferior colliculus in the gerbil, Meriones unguiculatus
    Victoria M Bajo
    University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Comp Neurol 486:101-16. 2005
  5. pmc Longitudinal pattern of basilar membrane vibration in the sensitive cochlea
    Tianying Ren
    Oregon Hearing Research Center NRC 04, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Proc Natl Acad Sci U S A 99:17101-6. 2002
  6. pmc Dynamic interaction of Ih and IK-LVA during trains of synaptic potentials in principal neurons of the medial superior olive
    Sukant Khurana
    Section of Neurobiology and Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712 0248, USA
    J Neurosci 31:8936-47. 2011
  7. ncbi Effects of ventral tegmental area stimulation on the acquisition and long-term retention of active avoidance learning
    Anton Ilango
    Leibniz Institute for Neurobiology, Brenneckestrasse 6, D 39118 Magdeburg, Germany
    Behav Brain Res 225:515-21. 2011
  8. ncbi Differential neuromodulation of acquisition and retrieval of avoidance learning by the lateral habenula and ventral tegmental area
    Jason Shumake
    Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    J Neurosci 30:5876-83. 2010
  9. ncbi The efficacy of erythropoietin and its analogues in animal stroke models: a meta-analysis
    Jens Minnerup
    Department of Neurology, University of Munster, Germany
    Stroke 40:3113-20. 2009
  10. ncbi Reverse propagation of sound in the gerbil cochlea
    Tianying Ren
    Oregon Hearing Research Center, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, NRC 04, Portland, Oregon 97239 3098, USA
    Nat Neurosci 7:333-4. 2004

Detail Information

Publications265 found, 100 shown here

  1. pmc Activation of beta-catenin by carcinogenic Helicobacter pylori
    Aime T Franco
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    Proc Natl Acad Sci U S A 102:10646-51. 2005
    ..cag- strains or uninfected persons. These results indicate that H. pylori-induced dysregulation of beta-catenin-dependent pathways may explain in part the augmentation in the risk of gastric cancer conferred by this pathogen...
  2. pmc Localization of the cochlear amplifier in living sensitive ears
    Tianying Ren
    Oregon Hearing Research Center, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 6:e20149. 2011
    ..Although the cochlear amplifier is thought to be a local cellular process at an area basal to the response peak on the spiral basilar membrane, its location has not been demonstrated experimentally...
  3. pmc A deep sequencing approach to comparatively analyze the transcriptome of lifecycle stages of the filarial worm, Brugia malayi
    Young Jun Choi
    Department of Pathobiological Sciences, University of Wisconsin Madison, Madison, Wisconsin, USA
    PLoS Negl Trop Dis 5:e1409. 2011
    ..Here we report a comprehensive genome-wide survey of the developmental transcriptome of the human filarial parasite Brugia malayi...
  4. ncbi Descending projections from the auditory cortex to the inferior colliculus in the gerbil, Meriones unguiculatus
    Victoria M Bajo
    University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Comp Neurol 486:101-16. 2005
    ..Descending connections to the gerbil IC form a segregated system in which multiple descending channels originating from different neuronal subpopulations may modulate specific aspects of ascending auditory information...
  5. pmc Longitudinal pattern of basilar membrane vibration in the sensitive cochlea
    Tianying Ren
    Oregon Hearing Research Center NRC 04, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Proc Natl Acad Sci U S A 99:17101-6. 2002
    ....
  6. pmc Dynamic interaction of Ih and IK-LVA during trains of synaptic potentials in principal neurons of the medial superior olive
    Sukant Khurana
    Section of Neurobiology and Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712 0248, USA
    J Neurosci 31:8936-47. 2011
    ....
  7. ncbi Effects of ventral tegmental area stimulation on the acquisition and long-term retention of active avoidance learning
    Anton Ilango
    Leibniz Institute for Neurobiology, Brenneckestrasse 6, D 39118 Magdeburg, Germany
    Behav Brain Res 225:515-21. 2011
    ..This may reflect frustration from the omission of expected reward. These results are relevant for optimizing brain stimulation to improve learning...
  8. ncbi Differential neuromodulation of acquisition and retrieval of avoidance learning by the lateral habenula and ventral tegmental area
    Jason Shumake
    Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    J Neurosci 30:5876-83. 2010
    ..These results demonstrate opponent roles of LHb and VTA during acquisition but not during retrieval of avoidance learning...
  9. ncbi The efficacy of erythropoietin and its analogues in animal stroke models: a meta-analysis
    Jens Minnerup
    Department of Neurology, University of Munster, Germany
    Stroke 40:3113-20. 2009
    ..We performed a meta-analysis to obtain an overall impression of the efficacy of EPO in published animal experimental stroke studies and for potential guidance of future clinical studies...
  10. ncbi Reverse propagation of sound in the gerbil cochlea
    Tianying Ren
    Oregon Hearing Research Center, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, NRC 04, Portland, Oregon 97239 3098, USA
    Nat Neurosci 7:333-4. 2004
    ..These results contradict the current theory and show that the ear emits sounds through the cochlear fluids as compression waves rather than along the basilar membrane as backward-traveling waves...
  11. ncbi The cochlear place-frequency map of the adult and developing Mongolian gerbil
    M Muller
    Klinikum der J W Goethe Universitat, Zentrum der Physiologie, Frankfurt am Main, Germany
    Hear Res 94:148-56. 1996
    ..5 kHz. A shift in the frequency map occurs during cochlear maturation. The place-frequency map in subadult gerbils (18 days after birth) is shifted by a distance corresponding to an octave, at least for frequencies above 6 kHz...
  12. ncbi Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits
    Qun Wang
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA
    J Neurosci Res 82:138-48. 2005
    ..Together, these findings attribute the neuroprotective effect of curcumin against I/R-induced neuronal damage to its antioxidant capacity in reducing oxidative stress and the signaling cascade leading to apoptotic cell death...
  13. ncbi The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test
    G B Varty
    CNS Biological Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    Behav Pharmacol 14:87-95. 2003
    ..These studies support both the utility of gerbils in behavioral pharmacology and the antidepressant potential of selective NK1 antagonists...
  14. ncbi Intestinal and hepatic cholesterol carriers in diabetic Psammomys obesus
    Emile Levy
    Gastroenterology, Hepatology, and Nutrition Unit, Research Centre, Sainte Justine Hospital, 3175 Sainte Catherine Road, Montreal, Quebec, Canada
    Endocrinology 151:958-70. 2010
    ..Our findings show that the development in P. obesus with T2D modifies the whole intraenterocyte and hepatocyte machinery responsible for CHOL homeostasis...
  15. ncbi AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties
    Sonia Carboni
    Department of Pharmacology, Serono Pharmaceutical Research Institute, Geneva, Switzerland
    J Pharmacol Exp Ther 310:25-32. 2004
    ..v. infusion (0.6 mg/kg/h) was also observed in rats after focal cerebral ischemia. These data suggest that the use of JNK inhibitors such as AS601245 may be a relevant strategy in the therapy of ischemic insults...
  16. ncbi Increase of extracellular dopamine in prefrontal cortex of gerbils during acquisition of the avoidance strategy in the shuttle-box
    H Stark
    Leibniz Institute for Neurobiology, Magdeburg, Germany
    Neurosci Lett 264:77-80. 1999
    ..It was found that exclusively strategy formation correlated with high DA levels in mPFC...
  17. pmc Y-like retinal ganglion cells innervate the dorsal raphe nucleus in the Mongolian gerbil (Meriones unguiculatus)
    Liju Luan
    Department of Anatomy, School of Basic Medical Sciences, Peking University, Beijing, China
    PLoS ONE 6:e18938. 2011
    ..However little is known regarding the type of retinal ganglion cell (RGC) that innervates the DRN. We examined morphological characteristics and physiological properties of these DRN projecting ganglion cells...
  18. ncbi Multi-unit mapping of acoustic stimuli in gerbil inferior colliculus
    D M Harris
    Yale University School of Medicine, New Haven, CT 06510, USA
    Hear Res 108:145-56. 1997
    ..This perspective of IC activity suggests potential processing mechanisms that are congruent with single-unit reconstructions...
  19. ncbi Stages of avoidance strategy formation in gerbils are correlated with dopaminergic transmission activity
    H Stark
    Leibniz Institute for Neurobiology, P O B 1860, D 39118, Magdeburg, Germany
    Eur J Pharmacol 405:263-75. 2000
    ..The increase in dopamine in medial prefrontal cortex may be an indicator of the involvement of working memory principles in signal evaluation stages of conditioning...
  20. ncbi An atlas of the inferior colliculus of the gerbil in three dimensions
    Nell B Cant
    Department of Neurobiology, Duke University Medical Center, P O Box 3209, Durham, NC 27710, USA
    Hear Res 206:12-27. 2005
    ..The atlas can be used for representation, comparison and correlation of neuroanatomical, neurophysiological, neurochemical and other data that can be spatially mapped in the inferior colliculus...
  21. ncbi Light deprivation induces depression-like behavior and suppresses neurogenesis in diurnal mongolian gerbil (Meriones unguiculatus)
    Benson Wui Man Lau
    Department of Anatomy, The State Key Laboratory of Brain and Cognitive Sciences, Research Centre of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong, Pokfulam, Hong Kong SAR, PR China
    Cell Transplant 20:871-81. 2011
    ..Additionally, the current experiment may offer a model for exploring the relationship among daylight exposure, circadian cycles, depressive behavior, and the underlying mechanisms...
  22. ncbi Evolutionary systematics in African gerbilline rodents of the genus Gerbilliscus: inference from mitochondrial genes
    Paolo Colangelo
    Dipartimento di Biologia Animale e dell Uomo, Universita di Roma La Sapienza, Via Borelli 50, 00161 Roma, Italy
    Mol Phylogenet Evol 42:797-806. 2007
    ..Our data seem to support the synonymy of the two taxa and suggest that Gerbillurus and Gerbilliscus lineages diverged from a common ancestor appeared in eastern Africa...
  23. ncbi Physical exercise enhances hepatic insulin signaling and inhibits phosphoenolpyruvate carboxykinase activity in diabetes-prone Psammomys obesus
    Yuval Heled
    Heller Institute of Medical Research and Pediatric Division, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Metabolism 53:836-41. 2004
    ..We conclude that exercise improves in vivo hepatic insulin sensitivity in diabetes-prone Psammomys-obesus...
  24. pmc Reverse wave propagation in the cochlea
    Wenxuan He
    Oregon Hearing Research Center, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, NRC04, Portland, OR 97239 3098, USA
    Proc Natl Acad Sci U S A 105:2729-33. 2008
    ..These data are in conflict with the backward- traveling-wave theory but are consistent with the idea that the emission comes out of the cochlea predominantly through compressional waves in the cochlear fluids...
  25. ncbi Rodents as reservoir hosts of cutaneous leishmaniasis in Jordan
    E K Saliba
    Department of Biological Sciences, University of Jordan, Amman
    Ann Trop Med Parasitol 88:617-22. 1994
    ..crassus, M. tristrami, Allactaga euphratica and Gerbillus spp.) yielded Leishmania parasites, confirming that P. obesus is the major reservoir host of cutaneous leishmaniasis in Jordan...
  26. ncbi Long-range effects of GABAergic inhibition in gerbil primary auditory cortex
    Christoph K Moeller
    Experimental Otolaryngology, University of Erlangen Nuremberg, Waldstr 1, 91054 Erlangen, Germany
    Eur J Neurosci 31:49-59. 2010
    ..These data demonstrate the existence of long-range, inhibitory interactions within the gerbil AI, realized either by long-range inhibitory projections or by long-range excitatory projections to local inhibitory interneurons...
  27. ncbi Early unilateral auditory deprivation increases 2-deoxyglucose uptake in contralateral auditory cortex of juvenile Mongolian gerbils
    I W Stuermer
    Leibniz Institute for Neurobiology, Brenneckestr 6, P O Box 1860, 39008, Magdeburg, Germany
    Hear Res 146:185-99. 2000
    ..Distances between tone-induced 2-DG labeling in AI and AAF were increased in PAX, but smaller in ATR in the right compared to the left hemisphere, suggesting effects of atresia also on spatial relations in cortical tonotopic maps...
  28. pmc Prolonged maturation of auditory perception and learning in gerbils
    Emma C Sarro
    Center for Neural Science, New York University, New York, New York 10003, USA
    Dev Neurobiol 70:636-48. 2010
    ..Furthermore, for several of the Juveniles with adult-like thresholds, AM detection deteriorated with repeated testing. Thus, immature perceptual skills in young animals were not associated with greater learning...
  29. ncbi Functional organization of auditory cortex in the Mongolian gerbil (Meriones unguiculatus). IV. Connections with anatomically characterized subcortical structures
    E Budinger
    Leibniz Institute for Neurobiology, Magdeburg, Germany
    Eur J Neurosci 12:2452-74. 2000
    ..The differences with respect to the existence and/or relative strengths of subcortical connections of the examined auditory cortical fields suggest a somewhat different function of each of these fields in auditory processing...
  30. ncbi Systematics and evolution of the subfamily Gerbillinae (Mammalia, Rodentia, Muridae)
    Pascale Chevret
    Institut des Sciences de l Evolution de Montpellier, Laboratoire de Paléontologie, Paléobiologie, Phylogénie, UMR CNRS 5554, Universite de Montpellier II, Place Emile Bataillon, 34095 Montpellier, France
    Mol Phylogenet Evol 35:674-88. 2005
    ..The subfamily Gerbillinae is no exception as previous studies based on morphological, karyotypical, and allozyme characters are highly ..
  31. ncbi Explosive chromosome evolution and speciation in the gerbil genus Taterillus (Rodentia, Gerbillinae): a case of two new cryptic species
    G Dobigny
    Laboratoire Mammifères et Oiseaux, Museum national d histoire naturelle, Paris, France
    Cytogenet Genome Res 96:117-24. 2002
    ..Possible factors responsible for the rapid karyotypic evolution and speciation in this West African gerbil complex are discussed...
  32. ncbi A quantitative analysis of psychometric functions for different auditory tasks in gerbils
    Otto Gleich
    ENT Department, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Hear Res 220:27-37. 2006
    ..In contrast, the steepness of the psychometric function is decreased in gerbils with impaired temporal resolution. We discuss these observations in the context of physiological data from young and old animals...
  33. ncbi Deafness disrupts chloride transporter function and inhibitory synaptic transmission
    Carmen Vale
    School of Medicine and Centro Regional de Investigaciones Biomedicas, University of Castilla La Mancha, Albacete 02071, Spain
    J Neurosci 23:7516-24. 2003
    ..This results in inhibitory synapses that are less able to block excitatory events...
  34. pmc Empirical assessment of a threshold model for sylvatic plague
    S Davis
    Department of Biology, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    J R Soc Interface 4:649-57. 2007
    ..Small sample size and local extinction received strong support and can account for most of the false positives. Host resistance received no support here but should be subject to more direct experimental testing...
  35. pmc Hearing loss alters the subcellular distribution of presynaptic GAD and postsynaptic GABAA receptors in the auditory cortex
    Emma C Sarro
    Center for Neural Science, New York University, New York, NY 10003, USA
    Cereb Cortex 18:2855-67. 2008
    ..Thus, both, the pre- and postsynaptic sides of inhibitory synapses that form upon pyramidal neurons of the ACx are regulated by neonatal auditory experience...
  36. pmc Hearing loss prevents the maturation of GABAergic transmission in the auditory cortex
    Vibhakar C Kotak
    Center for Neural Science, New York University, New York, NY 10003, USA
    Cereb Cortex 18:2098-108. 2008
    ..Together, these data strongly suggest that the presynaptic release properties and expression of key postsynaptic GABA(A) receptor subunits are coregulated by hearing...
  37. ncbi Measurement of cochlear power gain in the sensitive gerbil ear
    Tianying Ren
    Department of Otolaryngology and Head and Neck Surgery, Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nat Commun 2:216. 2011
    ..These results demonstrate experimentally that the cochlea amplifies soft sounds, offering insight into the mechanism responsible for the cochlear sensitivity...
  38. pmc Age-dependent effect of hearing loss on cortical inhibitory synapse function
    Anne E Takesian
    Center for Neural Science, New York University, New York, New York, USA
    J Neurophysiol 107:937-47. 2012
    ..These long-lasting changes to inhibitory function may contribute to the auditory processing deficits associated with early hearing loss...
  39. ncbi Experience-dependent refinement of the inhibitory axons projecting to the medial superior olive
    Florian Werthat
    Department Biologie II, Division of Neurobiology, LMU Munich, Grosshadernerstrasse 2, 82152 Martinsried, Germany
    Dev Neurobiol 68:1454-62. 2008
    ....
  40. ncbi Low rate of glucose 6-phosphate hydrolysis in liver cells is a physiological feature of non-diabetic wild sand rats (Psammomys obesus)
    E A Koceir
    INSERM E 0221 Bioénergétique Fondamentale et Appliquée, Universite Joseph Fourier, Grenoble, France
    Diabetes Metab 29:363-74. 2003
    ..Psammomys obesus is a natural model of insulin resistance when fed a rodent laboratory chow...
  41. pmc Asymmetric excitatory synaptic dynamics underlie interaural time difference processing in the auditory system
    Pablo E Jercog
    Physics Department, New York University, New York, New York, United States of America
    PLoS Biol 8:e1000406. 2010
    ..We suggest, more generally, that the dependence of spike probability on rate of depolarization, as in these auditory neurons, provides a mechanism for temporal order discrimination between EPSPs...
  42. ncbi The isolated in vitro perfused spiral modiolar artery: pressure dependence of vasoconstriction
    P Wangemann
    Cell Physiology Laboratory, Boys Town National Research Hospital, Omaha, NE 68131, USA
    Hear Res 115:113-8. 1998
    ....
  43. ncbi Helicobacter pylori cag-type IV secretion system facilitates corpus colonization to induce precancerous conditions in Mongolian gerbils
    Gabriele Rieder
    Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Ludwig Maximilians University, Munich, Germany
    Gastroenterology 128:1229-42. 2005
    ..The role of the Helicobacter pylori type IV secretion system (T4SS) for pathogenesis in the Mongolian gerbil model was explored...
  44. ncbi Mechanoelectric transduction of adult inner hair cells
    Shuping Jia
    Hair Cell Biophysics Laboratory, Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Neurosci 27:1006-14. 2007
    ..There is a phase lead of IHC transducer currents relative to sinusoidal BM displacement, reflecting viscoelastic coupling of their cilia and their adaptation process...
  45. ncbi Comparison of two genetically related Entamoeba histolytica cell lines derived from the same isolate with different pathogenic properties
    Laura Biller
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Proteomics 9:4107-20. 2009
    ..Summarized, a defined set of different proteins could be identified between cell lines A and B. These molecules may have an important role in amoeba pathogenicity...
  46. ncbi Interaction of excitation and inhibition in anteroventral cochlear nucleus neurons that receive large endbulb synaptic endings
    Cornelia Kopp-Scheinpflug
    Department of Neurobiology, University of Leipzig, 04103 Leipzig, Germany
    J Neurosci 22:11004-18. 2002
    ..The inhibition specifically affects the processing of the spectral, temporal, and intensity cues of acoustic signals...
  47. ncbi Animal models of focal and global cerebral ischemia
    Richard J Traystman
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    ILAR J 44:85-95. 2003
    ..This review summarizes many (but not all) small and large animal models of focal and global cerebral ischemia and discusses their advantages and disadvantages...
  48. pmc Global versus local processing of frequency-modulated tones in gerbils: an animal model of lateralized auditory cortex functions
    Wolfram Wetzel
    Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
    Proc Natl Acad Sci U S A 105:6753-8. 2008
    ..The left AC, by using local cues, discriminates gap durations and determines FM direction only when additional segmental information is available...
  49. ncbi Dynamics of Leishmania infection rates in Rhombomys opimus (Rodentia: Gerbillinae) population of an endemic focus of zoonotic cutaneous leishmaniasis in Iran
    A A Akhavan
    Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Bull Soc Pathol Exot 103:84-9. 2010
    ..In this study, seasonal variation of natural infection with Leishmania parasites in Rhombomys opimus (Rodentia: Gerbillinae) population of an endemic focus of ZCL in Iran was monitored...
  50. pmc Two-tone distortion at different longitudinal locations on the basilar membrane
    Wenxuan He
    Oregon Hearing Research Center, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, Portland, OR 97239 3098, USA, and Department of Otolaryngology of First Affiliated Hospital, Xi an, Shaanxi 710061, PR China
    Hear Res 228:112-22. 2007
    ..The data indicate that the emission travels along the BM from base to apex as a forward traveling wave, and no backward traveling wave was detected under the current experimental conditions...
  51. ncbi Diurnal variation of c-Fos expression in subdivisions of the dorsal raphe nucleus of the Mongolian gerbil (Meriones unguiculatus)
    S Janusonis
    Neuroscience and Behavior Program, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Comp Neurol 440:31-42. 2001
    ..These results suggest that DRN subdivisions may differ functionally with regard to the diurnal cycle, and that these differences may be reflected in the activity of nonserotonergic cells in the DRN...
  52. ncbi Multisensory processing via early cortical stages: Connections of the primary auditory cortical field with other sensory systems
    E Budinger
    Leibniz Institute for Neurobiology, Department of Auditory Learning and Speech, Brenneckestrasse 6, D 39118 Magdeburg, Germany
    Neuroscience 143:1065-83. 2006
    ..the somatosensory and olfactory ones) multisensory information is probably also processed in these cortices. This suggests more generally, that primary sensory cortices may not be unimodal...
  53. pmc Gender differences in myogenic regulation along the vascular tree of the gerbil cochlea
    Katrin Reimann
    Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas, United States of America
    PLoS ONE 6:e25659. 2011
    ..Male spiral modiolar arteries responded more to L-NNA than female spiral modiolar arteries, suggesting that NO-dependent mechanisms play a bigger role in the myogenic regulation of male than female gerbil cochlear vessels...
  54. pmc Presynaptic GABA(B) receptors regulate experience-dependent development of inhibitory short-term plasticity
    Anne E Takesian
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 30:2716-27. 2010
    ..This novel synaptic mechanism may support the emergence of mature temporal processing in the auditory cortex...
  55. ncbi Reverse cochlear propagation in the intact cochlea of the gerbil: evidence for slow traveling waves
    Sebastiaan W F Meenderink
    Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Neurophysiol 103:1448-55. 2010
    ..These delays remained significant after compensating for middle-ear delay. The results contradict the hypothesis that the reverse propagation of emissions is exclusively by direct pressure waves...
  56. pmc Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets
    Kathrin Maedler
    Division of Endocrinology and Diabetes, University Hospital, Zurich, Switzerland
    J Clin Invest 110:851-60. 2002
    ..These findings implicate an inflammatory process in the pathogenesis of glucotoxicity in type 2 diabetes and identify the IL-1beta/NF-kappaB pathway as a target to preserve beta cell mass and function in this condition...
  57. ncbi The effect of Helicobacter felis and Helicobacter bizzozeronii on the gastric mucosa in Mongolian gerbils: a sequential pathological study
    M de Bock
    Departments of Pathology, Bacteriology and Avian Diseases, Faculty of Medicine, Ghent University, Belgium
    J Comp Pathol 135:226-36. 2006
    ..The mechanism by which H. felis induces PC necrosis and apoptosis remains unclear. The observed flagellar contact and NF-kappaB activation may play an important role in H. felis-associated inflammation...
  58. ncbi Late calcium EDTA rescues hippocampal CA1 neurons from global ischemia-induced death
    Agata Calderone
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 24:9903-13. 2004
    ..The finding of neuroprotection by late CaEDTA administration has striking implications for intervention in the delayed neuronal death associated with global ischemia...
  59. pmc Distortion product otoacoustic emissions evoked by tone complexes
    Sebastiaan W F Meenderink
    Department of Neuroscience, Erasmus MC, Dr Molewaterplein 50, Rotterdam, 3015 GE, The Netherlands
    J Assoc Res Otolaryngol 12:29-44. 2011
    ..We analyzed the relation between multitone-evoked DPOAEs and DPOAEs evoked by tone pairs, and explored the new degrees of freedom offered by the multitone paradigm...
  60. ncbi Mitochondrial metabolism reveals a functional architecture in intact islets of Langerhans from normal and diabetic Psammomys obesus
    S M Katzman
    Dept of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA
    Am J Physiol Endocrinol Metab 287:E1090-9. 2004
    ..These data support the hypothesis that glucose enhances metabolic coupling in normal islets and that the dampening of oscillatory insulin secretion in NIDDM may result from disrupted metabolic coupling...
  61. ncbi In vivo protein transduction: biologically active intact pep-1-superoxide dismutase fusion protein efficiently protects against ischemic insult
    Won Sik Eum
    Department of Genetic Engineering, Research Institute for Bioscience and Biotechnology, Hallym University, 1 1 Okchon Dong, Chunchon, Kangwon Do, Korea, 200 702, Korea
    Free Radic Biol Med 37:1656-69. 2004
    ..These results suggest that the biologically active intact forms of PEP-1-SOD provide a more efficient strategy for therapeutic delivery in various human diseases related to this antioxidant enzyme or to ROS, including stroke...
  62. pmc Exploiting development to evaluate auditory encoding of amplitude modulation
    Merri J Rosen
    Department of Anatomy and Neurobiology, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272, USA
    J Neurosci 30:15509-20. 2010
    ..However, if sAM detection is based on a population response, then immature detection thresholds are more likely caused by an inadequate sensory representation...
  63. ncbi Intracellularly labeled fusiform cells in dorsal cochlear nucleus of the gerbil. II. Comparison of physiology and anatomy
    Kenneth E Hancock
    Department of Biomedical Engineering and Hearing Research Center, Boston University, Boston, Massachusetts 02215 2407, USA
    J Neurophysiol 87:2520-30. 2002
    ..Such trends indicate that neighboring fusiform cells are endowed with different signal processing capabilities...
  64. ncbi Endothelin-1-induced vasospasms of spiral modiolar artery are mediated by rho-kinase-induced Ca(2+) sensitization of contractile apparatus and reversed by calcitonin gene-related Peptide
    Elias Q Scherer
    Anatomy and Physiology Department, Kansas State University, Manhattan, KS 66506, USA
    Stroke 33:2965-71. 2002
    ....
  65. pmc Normal hearing is required for the emergence of long-lasting inhibitory potentiation in cortex
    Han Xu
    Center for Neural Science and Department of Biology, New York University, New York, New York 10003, USA
    J Neurosci 30:331-41. 2010
    ..These data indicate that early experience is necessary for the normal development of BDNF-mediated long-lasting inhibitory potentiation, which may be associated with perceptual deficits at later ages...
  66. pmc Rapid loss of motility of Helicobacter pylori in the gastric lumen in vivo
    Sören Schreiber
    Institut fur Physiologie, MA 2 149, Ruhr Universitaet Bochum, Universitaetsstrasse 150, D 44801 Bochum, Germany
    Infect Immun 73:1584-9. 2005
    ..pylori in the gastric chymus to only a few minutes by rapidly inhibiting active motility. It is therefore likely that this short period of resistance in the gastric lumen is one of the most critical phases of Helicobacter infection...
  67. pmc Stage- and gender-specific proteomic analysis of Brugia malayi excretory-secretory products
    Yovany Moreno
    Institute of Parasitology, McGill University, Ste Anne de Bellevue, Quebec, Canada
    PLoS Negl Trop Dis 2:e326. 2008
    ..Little is known about the composition and variability of products released at different developmental stages and their contribution to parasite survival and progression of the infection...
  68. ncbi Antagonists of group I metabotropic glutamate receptors do not inhibit induction of ischemic tolerance in gerbil hippocampus
    Malgorzata Duszczyk
    Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Street, 02 106 Warsaw, Poland
    Neurochem Int 48:478-84. 2006
    ..Both antagonists did not inhibit the induction of ischemic tolerance. Thus, our data indicate that group I metabotropic glutamate receptors do not play an essential role in the induction of ischemic tolerance...
  69. ncbi Differential effects of iontophoretic application of the GABAA-antagonists bicuculline and gabazine on tone-evoked local field potentials in primary auditory cortex: interaction with ketamine anesthesia
    Simone Kurt
    Institute for Neurobiology, University of Ulm, Albert Einstein Allee 11, Ulm, Germany
    Brain Res 1220:58-69. 2008
    ..We conclude from the data presented that the main functional role of GABA(A)-mediated inhibition in auditory cortex is to (1) prevent over-excitation (seizures) of cortical networks and (2) to speed up cortical processing...
  70. pmc Waves on Reissner's membrane: a mechanism for the propagation of otoacoustic emissions from the cochlea
    Tobias Reichenbach
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065 6399, USA
    Cell Rep 1:374-84. 2012
    ..The results are in accord with the theory and thus support a role for Reissner's membrane in otoacoustic emissions...
  71. ncbi Unusually extensive karyotype reorganization in four congeneric Gerbillus species (Muridae: Gerbillinae)
    V M Aniskin
    Severtsov Institut of Ecology and Evolution, Russian Academy of Sciences, Moscow, Russia
    Cytogenet Genome Res 112:131-40. 2006
    ..Based on the chromosomal data obtained here, the systematic and geographic implications for these North African species are also discussed...
  72. pmc Simultaneous measurements of ossicular velocity and intracochlear pressure leading to the cochlear input impedance in gerbil
    O de La Rochefoucauld
    Department of Otolaryngology, Head and Neck Surgery, Columbia University, 630 West 168th Street, New York, NY, 10032, USA
    J Assoc Res Otolaryngol 9:161-77. 2008
    ..The observed wide-band intracochlear pressure and power flow are consistent with the wide-band audiogram of the gerbil...
  73. pmc Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses
    D A Israel
    Division of Gastroenterology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Clin Invest 107:611-20. 2001
    ..Use of an H pylori whole genome microarray is an effective method to identify differences in gene content between H. pylori strains that induce distinct pathological outcomes in a rodent model of H. pylori infection...
  74. ncbi Distinguishing cochlear pathophysiology in 4-aminopyridine and furosemide treated ears using a nonlinear systems identification technique
    L Bian
    Hearing and Speech Department, University of Kansas Medical Center, Kansas City 66160, USA
    J Acoust Soc Am 109:671-85. 2001
    ..It is concluded that the NLID technique is sensitive and specific to alterations in the cochlear physiology...
  75. pmc Reliability of synaptic transmission at the synapses of Held in vivo under acoustic stimulation
    Bernhard Englitz
    Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany
    PLoS ONE 4:e7014. 2009
    ..In vivo this discrepancy could be due to the difficulty in identifying failures of transmission...
  76. ncbi Multilinear models of single cell responses in the medial nucleus of the trapezoid body
    B Englitz
    Max Planck Institute for Mathematics in the Sciences, Inselstrasse 22, Leipzig, Germany
    Network 21:91-124. 2010
    ..In conclusion, the context model provides a rich and still interpretable extension over many previous phenomenological models for modeling responses in the auditory brainstem at submillisecond resolution...
  77. ncbi The sources of electrically evoked otoacoustic emissions
    Yuan Zou
    Oregon Hearing Research Center, Department of Otolaryngology, Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Hear Res 180:91-100. 2003
    ..One part of this energy propagates directly to the ear canal, forming the SDC, and the other part propagates to its CF place and is reflected from there to the ear canal, forming the LDC...
  78. pmc The spatial pattern of cochlear amplification
    Jonathan A N Fisher
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuron 76:989-97. 2012
    ..These results reveal the locus of amplification in cochlear traveling waves and connect the characteristics of normal hearing to molecular forces...
  79. ncbi Tadalafil improves short-term memory by suppressing ischemia-induced apoptosis of hippocampal neuronal cells in gerbils
    Il Gyu Ko
    Department of Physiology, College of Medicine, Kyung Hee University, 1 Hoigi dong, Dongdaemoon gu, Seoul 130 701, Republic of Korea
    Pharmacol Biochem Behav 91:629-35. 2009
    ..We showed that tadalafil can overcome ischemia-induced apoptotic neuronal cell death, thus facilitates recovery following ischemic cerebral injury...
  80. ncbi Gastric mucosal changes induced by long term infection with Helicobacter pylori in Mongolian gerbils: effects of bacteria eradication
    Y Keto
    Department of Applied Pharmacology, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8414, Japan
    J Physiol Paris 95:429-36. 2001
    ..It was concluded that early eradication of H. pylori infection with drug therapy can prevent severe gastric mucosal changes, to include adenocarcinomas, in Mongolian gerbils...
  81. ncbi Effects of auditory stimulus context on the representation of frequency in the gerbil inferior colliculus
    B J Malone
    Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA
    J Neurophysiol 86:1113-30. 2001
    ..The demonstration that conditioning effects reflect sensitivity to spectral as well as spatial stimulus contrast has broad implications for the processing of a wide range of dynamic acoustic signals and sound sequences...
  82. pmc Gerbil middle-ear sound transmission from 100 Hz to 60 kHz
    Michael E Ravicz
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, Massachusetts 02114, USA
    J Acoust Soc Am 124:363-80. 2008
    ....
  83. pmc Different expression patterns of Ngb and EPOR in the cerebral cortex and hippocampus revealed distinctive therapeutic effects of intranasal delivery of Neuro-EPO for ischemic insults to the gerbil brain
    Yan Gao
    Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, PR China
    J Histochem Cytochem 59:214-27. 2011
    ..The different expression patterns of Ngb and EPOR is probably due to ischemic tolerance in the cerebral cortex and ischemic sensitivity in the hippocampus...
  84. ncbi Systematics and phylogeny of West African gerbils of the genus Gerbilliscus (Muridae: Gerbillinae) inferred from comparative G- and C-banding chromosomal analyses
    V Volobouev
    Museum national d histoire naturelle, UMR 5202 Origine, Structure et Evolution de la Biodiversité, Paris, France
    Cytogenet Genome Res 116:269-81. 2007
    ....
  85. ncbi Spiking neurons learning phase delays: how mammals may develop auditory time-difference sensitivity
    Christian Leibold
    Physik Department, Technische Universitat Munchen, 85747 Garching bei Munchen, Germany
    Phys Rev Lett 94:168102. 2005
    ..By means of a biophysical model we show how spike-timing-dependent synaptic learning explains precise interplay of excitation and inhibition and, hence, accounts for a physical realization of a phase delay...
  86. ncbi Functional correlates of characteristic frequency in single cochlear nerve fibers of the Mongolian gerbil
    K K Ohlemiller
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208
    J Comp Physiol A 167:329-38. 1990
    ..These results are compared with similar data from other species and discussed in terms of recent studies on sound communication and cochlear anatomy in gerbils...
  87. ncbi Population coding of interaural time differences in gerbils and barn owls
    Nicholas A Lesica
    Division of Neurobiology, Department Biology II, Ludwig Maximilians University Munich, Martinsried, Germany
    J Neurosci 30:11696-702. 2010
    ..Together, our results support the idea that, unlike the avian brain, the mammalian brain represents ITDs in the overall activity of a homogenous population of neurons within each hemisphere...
  88. ncbi Decrease of PKC precedes other cellular signs of calpain activation in area CA1 of the hippocampus after transient cerebral ischemia
    M Ziemka-Nałecz
    Laboratory of Molecular Neuropathology, Department of Neurochemistry, Medical Research Centre, Warsaw, Poland
    Neurochem Int 42:205-14. 2003
    ....
  89. ncbi Enhancement of ITD coding within the initial stages of the auditory pathway
    Michael Pecka
    Department of Biology II, Ludwig Maximilians University Munich, Martinsried, Germany
    J Neurophysiol 103:38-46. 2010
    ....
  90. ncbi Retinal afferents to the dorsal raphe nucleus in rats and Mongolian gerbils
    K V Fite
    Neuroscience and Behavior Program, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Comp Neurol 414:469-84. 1999
    ..Major differences observed in the extent and configuration of the retinal-DRN pathway may be related to the diurnal/crepuscular vs. nocturnal habits of these two species...
  91. ncbi Retinal ganglion cells projecting to the dorsal raphe and lateral geniculate complex in Mongolian gerbils
    Katherine V Fite
    Neuroscience and Behavior Program, Tobin Hall, University of Massachusetts, Amherst, MA 01003, USA
    Brain Res 973:146-50. 2003
    ..DL RGC soma diameters fell primarily within the mid-to-upper size range of all three distributions. DL RGCs may provide information to both nuclei concerning comparable aspects of light and visual stimulation via collateralized axons...
  92. ncbi Evidence for multiple DPOAE components based upon group delay of the 2f(1)-f(2) distortion in the gerbil
    M Faulstich
    Zoologisches Institut der Universität München, Luisenstr 14, 80333, Munich, Germany
    Hear Res 140:99-110. 2000
    ..5 kHz but failed to reflect the sensitivity for lower frequencies. This may be a consequence of more linear frequency processing in the apex...
  93. ncbi Ca2+-dependence and nifedipine-sensitivity of vascular tone and contractility in the isolated superfused spiral modiolar artery in vitro
    P Wangemann
    Cell Physiology Laboratory, Boys Town National Research Hospital, Omaha, NE 68131, USA
    Hear Res 118:90-100. 1998
    ..Further, the data suggest that cytosolic Ca2+ stores, if present in the spiral modiolar artery, are of limited capacity compared to other vessels...
  94. ncbi Spectral composition of concurrent noise affects neuronal sensitivity to interaural time differences of tones in the dorsal nucleus of the lateral lemniscus
    Ida Siveke
    Division of Neurobiology, Department Biology II, Ludwig Maximilians Universitat Munchen, Germany
    J Neurophysiol 98:2705-15. 2007
    ..A simple simulation corroborates this interpretation. Taken together, these findings suggest that the spectral composition of a concurrent sound strongly influences the spatial processing of ITD-sensitive DNLL neurons...
  95. ncbi Cochlear mechanisms of frequency and intensity coding. I. The place code for pitch
    M Chatterjee
    Institute for Sensory Research, Syracuse University, NY 13244, USA
    Hear Res 111:65-75. 1997
    ..On the other hand, the recordings indicate that the apical cutoff of the spatial excitation pattern is SPL-independent. We conclude, therefore, that the place theory of pitch perception must be abandoned or at least modified...
  96. ncbi Evolution of rRNA gene clusters and telomeric repeats during explosive genome repatterning in TATERILLUS X (Rodentia, Gerbillinae)
    G Dobigny
    Laboratoire Origine, Structure et Evolution de la Biodiversité, Museum national d histoire naturelle, Paris, France
    Cytogenet Genome Res 103:94-103. 2003
    ..and telomeric repeats was performed using single and double FISH in the Taterillus genus (Rodentia, Muridae, Gerbillinae). Taterillus was previously demonstrated to have undergone a very recent and extensive chromosomal evolution...
  97. ncbi Intensity-dependent peak shift in cochlear transfer functions at the cellular level, its elimination by sound exposure, and its possible underlying mechanisms
    M Zhang
    Institute of Sensory Research, Syracuse University, NY 13244 5290, USA
    Hear Res 96:46-58. 1996
    ..Consequently, the feedback, when present, must shift the best frequency upward...
  98. ncbi Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia
    Claudio Hetz
    Serono Pharmaceutical Research Institute, 14 Chemin des Aulx, CH 1228 Plan les Ouates, Geneva, Switzerland
    J Biol Chem 280:42960-70. 2005
    ..The protective effect in the animal model correlated with decreased cytochrome c release in the infarcted area. This is the first demonstration that Bax channel activity is required in apoptosis...
  99. pmc Helicobacter pylori cag-Pathogenicity island-dependent early immunological response triggers later precancerous gastric changes in Mongolian gerbils
    Tobias Wiedemann
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 4:e4754. 2009
    ..The early cag-PAI-dependent immunological response triggers later physiological and histopathological alterations towards gastric malignancies...
  100. ncbi Synaptic transmission at the calyx of Held under in vivo like activity levels
    Joachim Hermann
    Ludwig Maximilians University, Munich, Germany
    J Neurophysiol 98:807-20. 2007
    ....
  101. ncbi Synaptic transmission and short-term plasticity at the calyx of Held synapse revealed by multielectrode array recordings
    Martin D Haustein
    Faculty of Biosciences, Pharmacy and Psychology, University of Leipzig, Leipzig, Germany
    J Neurosci Methods 174:227-36. 2008
    ..Moreover, MEAs enable convenient analysis of activity-dependent depression and modulation of neuronal activity by glycine and GABA at later developmental stages not accessible to patch recordings...

Research Grants62

  1. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..
  2. DEVELOPMENTAL STUDIES OF COCHLEAR MECHANICS
    David Mills; Fiscal Year: 2003
    ..abstract_text> ..
  3. Studies of cochlear mechanics: otoacoustic emissions
    Tianying Ren; Fiscal Year: 2005
    ..abstract_text> ..
  4. NEUROANATOMY OF THE AUDITORY SYSTEM
    Nell B Cant; Fiscal Year: 2010
    ..Detailed understanding of these connections will contribute to the development of rational, testable hypotheses about auditory function in both health and disease. ..
  5. QUANTITATIVE MORPHOPHYSIOLOGY OF VESTIBULAR AFFERENTS
    GOLDA KEVETTER; Fiscal Year: 2004
    ..This could prove important for treatment of patients with vestibular disorders, such as those suffering with Meniere's disease or even normal aging. ..
  6. Exploring otoacoustic emissions with intracochlear pressure measurements
    Wei Dong; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  7. Optical stimulation of the auditory nerve
    AGNELLA IZZO; Fiscal Year: 2006
    ..Aim (2) will utilize the variable-wavelength, variable-repetition rate Free Electron Laser to demonstrate optical stimulation of auditory neurons at high repetition rates. [unreadable] [unreadable] [unreadable]..
  8. Cell survival and cell death in the auditory nerve
    Hainan Lang; Fiscal Year: 2008
    ..abstract_text> ..
  9. Physiological Studies of Age-Related Hearing Loss
    RICHARD SCHMIEDT; Fiscal Year: 2007
    ..Taken together, the three aims explore the major causes and effects of metabolic presbyacusis and have direct application to future interventions to help restore age-related hearing loss. [unreadable] [unreadable]..
  10. Investigating the nature of prestin-associated proteins
    Jing Zheng; Fiscal Year: 2007
    ..This knowledge may make it possible to manipulate OHC function for therapeutic purposes. ..
  11. Transcription Factors & Inflammatory Mediators in Stroke
    Raghu Vemuganti; Fiscal Year: 2007
    ..The ultimate goal is to define the role of SOCS-3/STAT-3 in post-ischemic cerebral inflammation. ..
  12. Cardiac Function and Cardiac iron (T2*) in Thalassemia
    John Wood; Fiscal Year: 2007
    ..These studies will provide the necessary groundwork for longitudinal studies of cardiac iron load on cardiac performance in thalassemia patients. ..
  13. The Pharmacology Education Partnership
    ROCHELLE SCHWARTZ BLOOM; Fiscal Year: 2006
    ..Based on our previous study, the students learn science better too! ..
  14. COMPARATIVE SPEECH PERCEPTION
    JOAN SINNOTT; Fiscal Year: 2007
    ..As far as health-relatedness of the overall project, "monkey-model" data may contribute to the verification of currently proposed models of human infant speech perception development. ..
  15. Role of Egr-1 in post-stroke inflammation & brain damage
    Raghu Vemuganti; Fiscal Year: 2009
    ..The ultimate goal is to define the role of EgM and its regulators to develop therapies to control cerebral inflammation at the level of transcription. ..
  16. COCHLEAR NERVE DEVELOPMENT
    STEPHEN ECHTELER; Fiscal Year: 2001
    ..It is crucial to understand the cellular interactions that form and maintain these sensorineural elements if effective biological strategies are to be devised for their protection or repair. ..
  17. Hearing loss affects synaptic balance in auditory cortex
    Dan Sanes; Fiscal Year: 2009
    ..Together, the results are significant for understanding at a cellular level how auditory processing is influenced by mild to severe deafness, and how we might compensate for these deficits. ..
  18. Central Auditory system Effects of Auditory Deprivation
    Debara Tucci; Fiscal Year: 2006
    ..We hypothesize that the potential for reversibility will depend upon the type and severity of the structural modification induced by conductive impairment, and the developmental stage of the animal at the time of the insult. ..
  19. CLINICAL MEASURES OF AUDITORY LINEAR/NONLINEAR PROCESSES
    MARK CHERTOFF; Fiscal Year: 2004
    ..abstract_text> ..
  20. NEURAL AND ENDOCRINE REGULATION OF BRAIN AND BEHAVIOR
    Richard Wurtman; Fiscal Year: 2003
    ..abstract_text> ..
  21. Building the researchers in audiology and hearing
    Debara Tucci; Fiscal Year: 2003
    ....
  22. Circadian Rhythms: Photic Sensitivity and Behavior
    Roberto Refinetti; Fiscal Year: 2003
    ..abstract_text> ..
  23. TRANSIENT CEREBRAL ISCHEMIA & GABA NEUROTRANSMISSION
    ROCHELLE SCHWARTZ BLOOM; Fiscal Year: 2004
    ..Understanding how ischemic insults affect inhibitory neuronal transmission and how specific populations of neurons die will help us to identify new treatment strategies to prevent ischemia-induced neuronal death in humans. ..
  24. In Vitro Analysis of Embryonic Inner Ear Cells
    LYNNE BIANCHI; Fiscal Year: 2002
    ..Together, these experiments will provide information regarding the mechanisms used for organizing normal auditory and vestibular epithelia and may provide insight into means of treating congenital anomalies of the inner ear...
  25. PSYCHOPHARMACOLOGICAL EFFECTS OF EXOGENOUS CHOLINE
    Richard Wurtman; Fiscal Year: 2008
    ..abstract_text> ..
  26. The Role of Corticotropin-Releasing Factor in Primate Maternal Behavior
    Wendy Saltzman; Fiscal Year: 2007
    ..Ultimately, this research will have implications for the understanding and treatment of stress-related psychopathology in women. [unreadable] [unreadable] [unreadable]..
  27. DEVELOPMENT OF INHIBITATION IN THE AUDITORY SYSTEM
    Dan Sanes; Fiscal Year: 2004
    ..abstract_text> ..
  28. CYTOSOLIC REGULATION OF INNER EAR ION TRANSPORT
    A PHILINE WANGEMANN; Fiscal Year: 2007
    ..first, middle) The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  29. GABA: EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2008
    ..GABA's excitatory actions during development are widespread throughout the brain. Thus, what we learn from our experiments on hypothalamic neurons should have general applicability to other CNS neurons. ..
  30. Genetics of Cryptosporidium parvum
    Giovanni Widmer; Fiscal Year: 2010
    ..Such valleys will be identified by quantitatively genotyping a selected and a control progeny population with a panel of single nucleotide polymorphisms. ..
  31. Nontypeable Haemophilus influenzae & host cell signaling
    WILLIAM SWORDS; Fiscal Year: 2003
    ..abstract_text> ..
  32. STRUCTURE/FUNCTION RELATIONS OF COCHLEAR NUCLEUS NEURONS
    HERBERT VOIGT; Fiscal Year: 2001
    ....
  33. Hypocretin Neurons
    Anthony N van den Pol; Fiscal Year: 2010
    ..Understanding the role of the endogenous opioid in hypocretin cells should also facilitate the understanding and treatment of narcolepsy. ..
  34. Functional Genomics of Cryptosporidium parvum
    Giovanni Widmer; Fiscal Year: 2007
    ..parvum. A comparison of the host cell response to C. parvum type 1 and type 2 will be performed to probe the molecular basis of the observed difference in virulence between types. ..
  35. Genetics of Cryptosporidium parvum
    Giovanni Widmer; Fiscal Year: 2008
    ..Mutations will be mapped to the genome of C. hominis, C. muris and more distantly related apicomplexan to identify those most likely to affect protein function or transcriptional regulation. ..
  36. GABA Receptors in the Acquisition and Extinction of Fear
    Scott Heldt; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  37. PHOTOPERIODIC CONTROL OF OBESITY
    Timothy Bartness; Fiscal Year: 2008
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers 1 Face Page .................................................................................................................................................. Description, ..
  38. ASM Conference on Pasteurellaceae
    WILLIAM SWORDS; Fiscal Year: 2008
    ..Thus, this meeting bridges multiple disciplines to provide opportunity for exchange and development of ideas. [unreadable] [unreadable] [unreadable]..
  39. Neurotransmission at the vestibular calyx synapse
    KATHERINE RENNIE; Fiscal Year: 2007
    ..The combination of experimental & modeling approaches will elucidate how sensory information is transformed by HC1 & converted into a neural code by their afferents. ..
  40. Ion Transport Mechanisms in Type I Fibrocytes
    Zhijun Shen; Fiscal Year: 2003
    ....
  41. Role of vestibular cortex in SCD subjects using fMRI
    Galen Kaufman; Fiscal Year: 2004
    ..abstract_text> ..
  42. MECHANISMS OF SEXUAL DIFFERENTIATION IN NEURAL SYSTEMS
    NANCY FORGER; Fiscal Year: 2004
    ....
  43. Nonhematopoietic Developmental Functions of EPO
    Sandra Juul; Fiscal Year: 2004
    ..We feel these experiments will provide important specific insights into the regulation of neonatal intestinal growth and injury. ..
  44. Epo as a Rescue Agent for Perinatal Hypoxia-Ischemia
    Sandra Juul; Fiscal Year: 2004
    ....
  45. FUNCTIONAL CORRELATES OF MOLECULAR MARKERS OF ADAPTATION
    Galen Kaufman; Fiscal Year: 2004
    ..These findings could provide evidence regarding how the brain develops sensorimotor sets appropriate for two environments. ..
  46. MECHANOELECTRICAL TRANSDUCTION IN ADULT OUTER HAIR CELLS
    David He; Fiscal Year: 2004
    ....
  47. Generation of antigen specific regulatory T cells
    Chenthamarakshan Vasu; Fiscal Year: 2005
    ..In aim-l, we will test the efficacy of BiAb in inducing regulatory T cells in vivo and in vitro. In aim-2, we will test the ability of these regulatory T cells in down modulating EAT and CIA. ..
  48. Novel therapeutics for chronic pain
    Paul Wood; Fiscal Year: 2005
    ....
  49. Genetic Transformation of Cryptosporidium parvum
    Giovanni Widmer; Fiscal Year: 2005
    ..Approach: Transformation by electroporation of sporozoites with GFP expression plasmids; detection of transformants in cell culture by fluorescent microscopy, anti-GFP antibodies, or reverse-transcriptase PCR. ..
  50. Mycobacterium tuberculosis in vivo gene expression
    James Graham; Fiscal Year: 2005
    ..Understanding the roles of such differentially expressed genes will further define host-pathogen interactions in human disease, and allow development of new tools to reduce the enormous global impact of tuberculosis on mankind. ..
  51. Low Optical Coherence Interferometry for the Cochlea
    Alfred Nuttall; Fiscal Year: 2007
    ..abstract_text> ..
  52. VESTIBULAR NUCLEUS ACTIVITY IN VESTIBULAR COMPENSATION
    SHAWN NEWLANDS; Fiscal Year: 2003
    ..abstract_text> ..
  53. Mechanics of Hearing Meeting 2005
    Alfred Nuttall; Fiscal Year: 2005
    ..In addition, attendees will receive information and experience in how to be proactive in the area of public education for hearing science. ..
  54. THE MECHANISM OF OUTER HAIR CELL MOTILITY
    Richard Hallworth; Fiscal Year: 2004
    ..In Aim 3, the role of the cortex, a subcellular structure in OHC stiffness will be determined using a developmental approach. ..
  55. Development of 13C-retinol isotope dilution techniques
    Sherry Tanumihardjo; Fiscal Year: 2006
    ..abstract_text> ..
  56. COCHLEAR VULNERABILITY/REACTIVE OXYGEN SPECIES
    KEVIN OHLEMILLER; Fiscal Year: 2003
    ..Our experiments will establish how well the dynamics of ROS production predict cochlear injury, and whether progressive deafness genes may impair cochlear ROS regulation. ..
  57. PRESYNAPTIC LONG-TERM SYNAPTIC DEPRESSION
    PATRIC STANTON; Fiscal Year: 2008
    ..The long-term regulation of transmitter release has far-reaching importance to normal synaptic processing dynamics, and controlling pathologic glutamate release during injury or disease. ..
  58. Genetic Modulation of Noise Injury to the Cochlear Lateral Wall
    KEVIN OHLEMILLER; Fiscal Year: 2009
    ..The gene, and the processes in which it is involved, may affect the long-term stability of cochlear injury, and the accumulation of injury that may be diagnosed as presbycusis. ..
  59. Genetic Modulation of Noise Injury to the Cochlear Lateral Wall
    KEVIN OHLEMILLER; Fiscal Year: 2007
    ..The gene, and the processes in which it is involved, may affect the long-term stability of cochlear injury, and the accumulation of injury that may be diagnosed as presbycusis. ..
  60. Microfilarial enhancement of Dengue transmission
    JEFFERSON VAUGHAN; Fiscal Year: 2002
    ....