mesocricetus

Summary

Summary: A genus of the family Muridae having three species. The present domesticated strains were developed from individuals brought from Syria. They are widely used in biomedical research.

Top Publications

  1. ncbi Binocular interactions in the entrainment and phase shifting of locomotor activity rhythms in Syrian hamsters
    Jin Ho Park
    Department of Psychology, University of California, Berkeley, CA 94720 1650, USA
    J Biol Rhythms 20:49-59. 2005
  2. ncbi Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy
    B W Caughey
    NIAID, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840
    Biochemistry 30:7672-80. 1991
  3. ncbi The hamster as a model of human visceral leishmaniasis: progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine response
    P C Melby
    Medical Service, Department of Veterans Affairs Medical Center, South Texas Veterans Health Care System, San Antonio, TX 78284, USA
    J Immunol 166:1912-20. 2001
  4. ncbi Protease-sensitive scrapie prion protein in aggregates of heterogeneous sizes
    Salit Tzaban
    Department of Molecular Biology, The Hebrew University Hadassah Medical School, and Hadassah University Hospital, Jerusalem 91120, Israel
    Biochemistry 41:12868-75. 2002
  5. pmc Strain-specified relative conformational stability of the scrapie prion protein
    D Peretz
    Institute for Neurodegenerative Diseases, University of California, San Francisco, California 94143, USA
    Protein Sci 10:854-63. 2001
  6. pmc Recombinant prion protein induces a new transmissible prion disease in wild-type animals
    Natallia Makarava
    Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
    Acta Neuropathol 119:177-87. 2010
  7. pmc Pathogenesis and host response in Syrian hamsters following intranasal infection with Andes virus
    David Safronetz
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America
    PLoS Pathog 7:e1002426. 2011
  8. pmc Validation of assays to monitor immune responses in the Syrian golden hamster (Mesocricetus auratus)
    Marko Zivcec
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    J Immunol Methods 368:24-35. 2011
  9. ncbi RNA molecules stimulate prion protein conversion
    Nathan R Deleault
    Department of Biochemistry, 7200 Vail Building, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Nature 425:717-20. 2003
  10. pmc Prion disease blood test using immunoprecipitation and improved quaking-induced conversion
    Christina D Orru
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    MBio 2:e00078-11. 2011

Research Grants

  1. ADOLESCENT ANABOLIC STEROIDS, VASOPRESSIN AND AGGRESSION
    Richard H Melloni; Fiscal Year: 2013
  2. Neurobiology of Social Behavior
    ELLIOTT ALBERS; Fiscal Year: 2005
  3. STUDIES ON MAMMALIAN OOCYTES (AND SPERMATOCYTES)
    GEORGIANA JAGIELLO; Fiscal Year: 1993
  4. TASTE QUALITY REPRESENTATION IN THE SOLITARY NUCLEUS
    MARION FRANK; Fiscal Year: 1992
  5. TEMPORAL INTEGRATION OF PHOTOPERIODIC SIGNALS IN MAMMALS
    Michael Gorman; Fiscal Year: 2002
  6. BRAIN MECHANISMS OF BEHAVIORAL DIMORPHISM
    C Carter; Fiscal Year: 1980
  7. Micellar VIP Nanoparticles for Rheumatoid Arthritis
    Israel Rubinstein; Fiscal Year: 2007
  8. Human Salty and Bitter Taste Mechanisms
    MARION FRANK; Fiscal Year: 2007
  9. PERIPHERAL GUSTATORY PROCESSING
    MARION ELIZABETH FRANK; Fiscal Year: 2010
  10. Mechanisms of Stress-Induced Changes in Behavior
    Matthew Cooper; Fiscal Year: 2006

Detail Information

Publications301 found, 100 shown here

  1. ncbi Binocular interactions in the entrainment and phase shifting of locomotor activity rhythms in Syrian hamsters
    Jin Ho Park
    Department of Psychology, University of California, Berkeley, CA 94720 1650, USA
    J Biol Rhythms 20:49-59. 2005
    ..Photic and nonphotic explanations for eventual entrainment of locomotor rhythms are discussed, and evidence for asymmetrical photic input from the 2 eyes to the SCN is considered...
  2. ncbi Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy
    B W Caughey
    NIAID, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840
    Biochemistry 30:7672-80. 1991
    ..The infrared-based secondary structure compositions were then used as constraints to improve the theoretical localization of the secondary structures within PrP-res 27-30...
  3. ncbi The hamster as a model of human visceral leishmaniasis: progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine response
    P C Melby
    Medical Service, Department of Veterans Affairs Medical Center, South Texas Veterans Health Care System, San Antonio, TX 78284, USA
    J Immunol 166:1912-20. 2001
    ..Remarkably, infection of the Syrian hamster (Mesocricetus auratus) with L...
  4. ncbi Protease-sensitive scrapie prion protein in aggregates of heterogeneous sizes
    Salit Tzaban
    Department of Molecular Biology, The Hebrew University Hadassah Medical School, and Hadassah University Hospital, Jerusalem 91120, Israel
    Biochemistry 41:12868-75. 2002
    ..Whether these new PrP(Sc) species play a role in the biogenesis or the pathogenesis of prions remains to be established...
  5. pmc Strain-specified relative conformational stability of the scrapie prion protein
    D Peretz
    Institute for Neurodegenerative Diseases, University of California, San Francisco, California 94143, USA
    Protein Sci 10:854-63. 2001
    ..Based on these results, the eight prion strains segregated into four distinct groups. Our results support the unorthodox proposal that distinct PrP(Sc) conformers encipher the biological properties of prion strains...
  6. pmc Recombinant prion protein induces a new transmissible prion disease in wild-type animals
    Natallia Makarava
    Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
    Acta Neuropathol 119:177-87. 2010
    ..Our studies establish that transmissible prion disease can be induced in wild-type animals by inoculation of rPrP and introduce a valuable new model of prion diseases...
  7. pmc Pathogenesis and host response in Syrian hamsters following intranasal infection with Andes virus
    David Safronetz
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America
    PLoS Pathog 7:e1002426. 2011
    ....
  8. pmc Validation of assays to monitor immune responses in the Syrian golden hamster (Mesocricetus auratus)
    Marko Zivcec
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    J Immunol Methods 368:24-35. 2011
    The Syrian golden hamster (Mesocricetus auratus) is a valuable but under-utilized animal model for studies of human viral pathogens such as bunyaviruses, arenaviruses, flaviviruses, henipaviruses, and SARS-coronavirus...
  9. ncbi RNA molecules stimulate prion protein conversion
    Nathan R Deleault
    Department of Biochemistry, 7200 Vail Building, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Nature 425:717-20. 2003
    ..They also provide a practical approach to improve the sensitivity of diagnostic techniques based on PrPres amplification...
  10. pmc Prion disease blood test using immunoprecipitation and improved quaking-induced conversion
    Christina D Orru
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    MBio 2:e00078-11. 2011
    ..This combined assay, which we call "enhanced QuIC" (eQuIC), markedly improves prospects for routine detection of low levels of prions in tissues, fluids, or environmental samples...
  11. ncbi Characterisation of antimony-resistant Leishmania donovani isolates: biochemical and biophysical studies and interaction with host cells
    Rupkatha Mukhopadhyay
    Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, Kolkata, India
    Int J Parasitol 41:1311-21. 2011
    ..The above results reinforce the notion that antimony resistant parasites have undergone a number of biochemical and biophysical changes as part of their adaptation to ensure their survival in the host...
  12. pmc Photoperiod and reproductive condition are associated with changes in RFamide-related peptide (RFRP) expression in Syrian hamsters (Mesocricetus auratus)
    Alex O Mason
    Department of Psychology, University of California, Berkeley, CA 94720 1650, USA
    J Biol Rhythms 25:176-85. 2010
    ..of the hypothalamus (DMH) has been implicated in seasonal changes in reproductive function in Syrian hamsters (Mesocricetus auratus), although the specific-cell phenotype decoding photoperiodic information remains unknown...
  13. pmc Assessing changes in vascular permeability in a hamster model of viral hemorrhagic fever
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA
    Virol J 7:240. 2010
    ..Although rodent models have been used to evaluate treatments for increased vascular permeability (VP) in bacterial sepsis, such studies have not been performed for VHF...
  14. ncbi Refractoriness to the treatment of sodium stibogluconate in Indian kala-azar field isolates persist in in vitro and in vivo experimental models
    Anuradha Dube
    Division of Parasitology, Central Drug Research Institute, Post Box No 173, Lucknow 226 001, India
    Parasitol Res 96:216-23. 2005
    ..Two isolates were also transfected with green fluorescent protein (GFP) for the development of in vitro assay for studying antileishmanial activities of new and reference drugs in macrophages by flow cytometry...
  15. pmc Formation of native prions from minimal components in vitro
    Nathan R Deleault
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 104:9741-6. 2007
    ..These results show that prions able to infect wild-type hamsters can be formed from a minimal set of components including native PrP(C) molecules, copurified lipid molecules, and a synthetic polyanion...
  16. pmc Cloning of Syrian hamster (Mesocricetus auratus) cytokine cDNAs and analysis of cytokine mRNA expression in experimental visceral leishmaniasis
    P C Melby
    Department of Veterans Affairs Medical Center, and Department of Medicine, The University of Texas Health Science Center, San Antonio 78284 7881, USA
    Infect Immun 66:2135-42. 1998
    The Syrian golden hamster (Mesocricetus auratus) is uniquely susceptible to a variety of intracellular pathogens and is an excellent model for a number of human infectious diseases...
  17. pmc T cells are not required for pathogenesis in the Syrian hamster model of hantavirus pulmonary syndrome
    Christopher D Hammerbeck
    U S Army Medical Research Institute of Infectious Diseases, Virology Division, Fort Detrick, MD 21702, USA
    J Virol 85:9929-44. 2011
    ..Moreover, these data argue for a mechanism of hantavirus-induced vascular permeability that does not involve T cell immunopathology...
  18. pmc Clinical outcome of henipavirus infection in hamsters is determined by the route and dose of infection
    Barry Rockx
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Virol 85:7658-71. 2011
    ....
  19. ncbi Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei
    Patricia V Agostino
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Roque Saenz Pena 180, Bernal 1876, Buenos Aires, Argentina
    Neurochem Int 44:617-25. 2004
    ....
  20. pmc A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum
    Michael Cappello
    Program in International Child Health, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:15154-9. 2006
    ..These data demonstrate that Cry5B is highly active in vitro and in vivo against a globally significant nematode parasite and that Cry5B warrants further clinical development for human and veterinary use...
  21. ncbi Immunization with the DNA-encoding N-terminal domain of proteophosphoglycan of Leishmania donovani generates Th1-type immunoprotective response against experimental visceral leishmaniasis
    Mukesh Samant
    Central Drug Research Institute, Lucknow, India
    J Immunol 183:470-9. 2009
    ..We further evaluated the DNA-encoding N-terminal domain of the ppg gene as a vaccine in golden hamsters (Mesocricetus auratus) against the L. donovani challenge...
  22. pmc Nipah virus transmission in a hamster model
    Emmie de Wit
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    PLoS Negl Trop Dis 5:e1432. 2011
    ..The data provide new and much-needed insights into the modes and efficiency of Nipah virus transmission and have important public health implications with regards to the risk assessment and management of future Nipah virus outbreaks...
  23. pmc Immunostimulatory cellular responses of cured Leishmania-infected patients and hamsters against the integral membrane proteins and non-membranous soluble proteins of a recent clinical isolate of Leishmania donovani
    R Garg
    Division of Parasitology, Central Drug Research Institute, Lucknow, India
    Clin Exp Immunol 140:149-56. 2005
    ..These results suggest that protective, immunostimulatory molecules are present in the IMP and NSP fractions, which may be exploited for development of a subunit vaccine for VL...
  24. ncbi Suprachiasmatic regulation of circadian rhythms of gene expression in hamster peripheral organs: effects of transplanting the pacemaker
    Hongnian Guo
    Department of Biology and Program in Neuroscience and Behavior, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Neurosci 26:6406-12. 2006
    ..Furthermore, the results indicate that conventional models of internal entrainment may need to be revised to explain control of the periphery by the pacemaker...
  25. ncbi The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice
    J Hsieh
    Department of Biochemistry, University of Toronto, Toronto, ON, Canada
    Diabetologia 53:552-61. 2010
    ..As dyslipidaemia is a contributing risk factor for cardiovascular disease in type 2 diabetes, we examined the mechanisms linking pharmacological and physiological regulation of GLP-1 action to control of postprandial lipid metabolism...
  26. pmc Rapid down-regulation of mammalian period genes during behavioral resetting of the circadian clock
    E S Maywood
    Department of Anatomy, Downing Street, University of Cambridge, Cambridge, United Kingdom CB2 3DY
    Proc Natl Acad Sci U S A 96:15211-6. 1999
    ..Moreover, this study provides an explanation at the molecular level for the contrasting but convergent effects of photic and nonphotic cues on the clock...
  27. ncbi Eight prion strains have PrP(Sc) molecules with different conformations
    J Safar
    Department of Neurology, University of California, San Francisco 94143 0518, USA
    Nat Med 4:1157-65. 1998
    ....
  28. ncbi In vitro generation of infectious scrapie prions
    Joaquin Castilla
    Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Cell 121:195-206. 2005
    ..These findings demonstrate that prions can be generated in vitro and provide strong evidence in support of the protein-only hypothesis of prion transmission...
  29. pmc Natural and synthetic prion structure from X-ray fiber diffraction
    Holger Wille
    Institute for Neurodegenerative Diseases, Departments of Neurology and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:16990-5. 2009
    ....
  30. ncbi Identification of an avirulent Entamoeba histolytica strain with unique tRNA-linked short tandem repeat markers
    Aleyla Escueta-de Cadiz
    Department of Parasitology, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Parasitol Int 59:75-81. 2010
    ..histolytica strains exist, that are associated with unique genotypes. Furthermore, STR genotyping and in vivo challenge of 2 other asymptomatic isolates (KU14 and KU26) verified the covert virulence of these strains...
  31. pmc The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis
    Everton F Silva
    Gonçalo Moniz Research Centre, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Brazil
    Vaccine 25:6277-86. 2007
    ..These findings indicate that the carboxy-terminal portion of LigA is an immunoprotective domain and may serve as a vaccine candidate for human and veterinary leptospirosis...
  32. ncbi High-level expression and characterization of a purified 142-residue polypeptide of the prion protein
    I Mehlhorn
    Department of Neurology, University of California, San Francisco 94143, USA
    Biochemistry 35:5528-37. 1996
    ..The high levels of purified rPrP which can now be obtained should facilitate determination of the multiple tertiary structures that Prp can adopt...
  33. pmc Major surface protein LipL32 is not required for either acute or chronic infection with Leptospira interrogans
    Gerald L Murray
    Department of Microbiology, Monash University, Clayton, Victoria, Australia
    Infect Immun 77:952-8. 2009
    ..and its absence in saprophytic Leptospira, this finding is remarkable. The role of this protein in leptospiral biology and pathogenesis thus remains elusive...
  34. pmc Glycosylation differences between the normal and pathogenic prion protein isoforms
    P M Rudd
    Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom
    Proc Natl Acad Sci U S A 96:13044-9. 1999
    ..The reduction in GnTIII activity is intriguing both with respect to the pathogenesis of the prion disease and the replication pathway for prions...
  35. ncbi Downregulation of follicle-stimulating hormone (FSH)-receptor messenger RNA levels in the hamster ovary: effect of the endogenous and exogenous FSH
    Yi Ming Zhang
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, 68198 4515, USA
    Biol Reprod 70:1580-8. 2004
    ..These data indicate that the nucleic acid sequence of hamster FSHR has been identified and that FSH modulates FSHR mRNA levels in the hamster ovary...
  36. ncbi Expression of the Per1 gene in the hamster: brain atlas and circadian characteristics in the suprachiasmatic nucleus
    S Yamamoto
    Department of Anatomy and Brain Science, Kobe University School of Medicine, Chuo-ku, Kobe 650-0017, Japan
    J Comp Neurol 430:518-32. 2001
    ..Lastly, in hamster brain, Per1 gene is also inducible in extra-SCN brain nuclei, since light at night also elicited Per1 mRNA in neurons of the hypothalamic paraventricular nucleus...
  37. ncbi Metabolic response of soy pinitol on lipid-lowering, antioxidant and hepatoprotective action in hamsters fed-high fat and high cholesterol diet
    Myung Sook Choi
    Department of Food Science and Nutrition, Kyungpook National University, Daegu, Korea
    Mol Nutr Food Res 53:751-9. 2009
    ..In particular, pinitol supplementation was very effective on the elevation of antiatherogenic factors, including plasma HDL-cholesterol, apo A-I, adiponectin, and PON...
  38. ncbi Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis
    Heather Basciano
    Department of Molecular Structure and Function, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Am J Physiol Endocrinol Metab 297:E462-73. 2009
    ..Dietary cholesterol appears to induce hepatic cholesterol ester and triglyceride accumulation, and diet-induced LXR activation (via cholesterol-derived oxysterols) may possibly be one key underlying mechanism...
  39. ncbi Screening and analysis of pathogenic genes during DMBA-induced buccal mucosa carcinogenesis in golden hamsters
    Kai Yang
    Department of Oral and Maxillofacial Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, PR China
    Oncol Rep 23:1619-24. 2010
    ..Searching for various effective inhibitors of xenobiotic metabolism by cytochrome P450 and the arachidonic acid metabolism pathway may suggest a therapy for the treatment and chemoprevention of oral squamous cell carcinoma...
  40. pmc Vesicular stomatitis virus-based vaccine protects hamsters against lethal challenge with Andes virus
    Kyle S Brown
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Virol 85:12781-91. 2011
    ..Overall, our data suggest the potential for the use of the VSV platform as a fast-acting and effective prophylaxis/postexposure treatment against lethal hantavirus infections...
  41. ncbi Elongation factor-2, a Th1 stimulatory protein of Leishmania donovani, generates strong IFN-γ and IL-12 response in cured Leishmania-infected patients/hamsters and protects hamsters against Leishmania challenge
    Pramod K Kushawaha
    Division of Parasitology, Central Drug Research Institute, Lucknow 226 001, India
    J Immunol 187:6417-27. 2011
    ..protein (LelF-2) and its immunogenicity in PBMCs of cured/exposed Leishmania-infected patients and hamsters (Mesocricetus auratus)...
  42. ncbi Intestinal absorption and histomorphometry of Syrian hamsters (Mesocricetus auratus) experimentally infected with Lawsonia intracellularis
    Fabio Augusto Vannucci
    Department of Veterinary Clinic and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    Vet Microbiol 145:286-91. 2010
    ..intracellularis. Therefore, malabsorption should be considered as the main mechanism involved in the physiopathology of the diarrhea in L. intracellularis infected animals...
  43. pmc Photodynamic therapy of early squamous cell carcinoma with tetra(m-hydroxyphenyl)chlorin: optimal drug-light interval
    S Andrejevic Blant
    Department of Otolaryngology, Head and Neck Surgery CHUV Hospital, Lausanne, Switzerland
    Br J Cancer 76:1021-8. 1997
    ..The information obtained from these studies could well be relevant to clinical trials as it suggests that time delays between 4 and 8 days after i.v. injection should be optimal for PDT of early malignancies in hollow organs...
  44. ncbi Expression of ER-alpha and ER-beta in the hamster ovary: differential regulation by gonadotropins and ovarian steroid hormones
    Peixin Yang
    Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, Nebraska 68198 4515, USA
    Endocrinology 143:2385-98. 2002
    ..ER expression was stimulated by estrogen, but progesterone strongly inhibited estrogen action. These results indicate that ER expression is cell type specific to the larger extent and is critically regulated by reproductive hormones...
  45. pmc Cure of hookworm infection with a cysteine protease inhibitor
    Jon J Vermeire
    Department of Pediatrics, Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA
    PLoS Negl Trop Dis 6:e1680. 2012
    ..Mass drug administration most often employs single-dose therapy with just two drugs of the same chemical class to which resistance is a growing concern. New chemical entities with the appropriate single-dose efficacy are needed...
  46. ncbi Pirital virus (Arenaviridae) infection in the syrian golden hamster, Mesocricetus auratus: a new animal model for arenaviral hemorrhagic fever
    S Y Xiao
    Department of Pathology, and the Center for Tropical Diseases, University of Texas Medical Branch, Galveston 77555 0588, USA
    Am J Trop Med Hyg 64:111-8. 2001
    ..It may also be useful for testingantiviral agents for treatment of arenaviral hemorrhagic fevers...
  47. ncbi Circulating microparticles and endothelial progenitor cells in atherosclerosis: pharmacological effects of irbesartan
    A Georgescu
    Petru Poni Institute of Macromolecular Chemistry, Iasi, Romania
    J Thromb Haemost 10:680-91. 2012
    ....
  48. pmc Treatment of spatial memory impairment in hamsters infected with West Nile virus using a humanized monoclonal antibody MGAWN1
    Cynthia A Smeraski
    Department of Biomedical Sciences, Animal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, USA
    Antiviral Res 91:43-9. 2011
    ..05). Overall these studies support the possibility that WNV can cause spatial memory impairment and that therapeutic intervention may be considered...
  49. ncbi Reversible remodeling of lung tissue during hibernation in the Syrian hamster
    Fatemeh Talaei
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, PO Box 196, 9700 RB Groningen, The Netherlands
    J Exp Biol 214:1276-82. 2011
    ....
  50. ncbi The flavonoid quercetin modulates the hallmark capabilities of hamster buccal pouch tumors
    Ramamurthi Vidya Priyadarsini
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Tamil Nadu, India
    Nutr Cancer 63:218-26. 2011
    ..A dietary phytochemical such as quercetin that modulates a plethora of molecules offers promise as an ideal candidate for multitargeted cancer prevention and therapy...
  51. ncbi Scrapie prion protein structural constraints obtained by limited proteolysis and mass spectrometry
    Gustavo Sajnani
    Prion Research Unit, School of Medicine, University of Santiago de Compostela, Rúa de San Francisco, s n 15782 Santiago de Compostela, Galicia, Spain
    J Mol Biol 382:88-98. 2008
    ..These results are compatible with a structure consisting of short beta-sheet stretches connected by loops and turns...
  52. pmc Prion shedding from olfactory neurons into nasal secretions
    Richard A Bessen
    Veterinary Molecular Biology, Montana State University, Bozeman, Montana, United States of America
    PLoS Pathog 6:e1000837. 2010
    ....
  53. pmc Neural mechanisms of individual and sexual recognition in Syrian hamsters (Mesocricetus auratus)
    Aras Petrulis
    Neuroscience Institute, Georgia State University, Atlanta, GA 30302 5030, USA
    Behav Brain Res 200:260-7. 2009
    ..Evidence is presented that analysis of social odors may initially be done in MEa and then communicated to MEpd, perhaps through micro-circuits that separately process male and female odors...
  54. pmc Therapeutic effect of melatonin in experimental uveitis
    Pablo Horacio Sande
    Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental, Universidad de Buenos Aires, Centro de Estudios Farmacológicos y Botánicos Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
    Am J Pathol 173:1702-13. 2008
    ....
  55. ncbi Genistein, a general kinase inhibitor, as a potential antiviral for arenaviral hemorrhagic fever as described in the Pirital virus-Syrian golden hamster model
    Eric M Vela
    Battelle Memorial Institute, 505 King Avenue, Columbus, OH 43201, USA
    Antiviral Res 87:318-28. 2010
    ..In all, the results from this study demonstrate the potential of a general kinase inhibitor genistein as an antiviral against arenaviral hemorrhagic fever...
  56. pmc Molecular interaction of TPPP with PrP antagonized the CytoPrP-induced disruption of microtubule structures and cytotoxicity
    Rui min Zhou
    State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People s Republic of China
    PLoS ONE 6:e23079. 2011
    ....
  57. ncbi Development of a hamster superovulation program and adverse effects of gonadotropins on microfilament formation during oocyte development
    Seung T Lee
    Division of Animal Genetic Engineering, School of Agricultural Biotechnology, Seoul National University, Sillim 9 Dong, Seoul 151 742, South Korea
    Fertil Steril 83:1264-74. 2005
    To establish a superovulation procedure for the golden hamster (Mesocricetus auratus) by elucidating gonadotropin effects on oocyte development.
  58. ncbi Dynamic analyses of PrP and PrP(Sc) in brain tissues of golden hamsters infected with scrapie strain 263K revealed various PrP forms
    Jian Mei Gao
    National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Yingxin Rd 100, Beijing 100052, China
    Biomed Environ Sci 17:8-20. 2004
    ....
  59. ncbi Detection of excretory/secretory coproantigens in experimental hookworm infection
    Richard D Bungiro
    Program in International Child Health, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8081, USA
    Am J Trop Med Hyg 73:915-20. 2005
    ..Examination of individual hookworm antigens by this method will provide new insights into the molecular host-parasite interaction and may form the basis for future diagnostic methods...
  60. pmc Treatment of yellow fever virus with an adenovirus-vectored interferon, DEF201, in a hamster model
    Justin G Julander
    Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Antimicrob Agents Chemother 55:2067-73. 2011
    ..Overall, it appears that DEF201 is effective in the treatment of YFV in a hamster model...
  61. ncbi Cytosolic PrP induces apoptosis of cell by disrupting microtubule assembly
    Xiao Li Li
    State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying Xin Rd 100, Beijing, 100052, People s Republic of China
    J Mol Neurosci 43:316-25. 2011
    ..The association of apoptosis with microtubule-disrupting activity caused by cytosolic PrP may further provide insight into the unresolved biological function of PrP in the neurons...
  62. ncbi The lysine- and glutamic acid-rich protein KERP1 plays a role in Entamoeba histolytica liver abscess pathogenesis
    Julien Santi-Rocca
    Institut Pasteur, Unité Biologie Cellulaire du Parasitisme, Paris, F 75015, France, and INSERM U786, Paris, F 75015, France
    Cell Microbiol 10:202-17. 2008
    ..Following its characterization as a marker for the progression of infection, KERP1 was also seen to be a virulence marker as trophozoites affected in kerp1 expression by an antisense strategy were unable to form liver abscesses...
  63. pmc Changes of tau profiles in brains of the hamsters infected with scrapie strains 263 K or 139 A possibly associated with the alteration of phosphate kinases
    Gui Rong Wang
    State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying Xin Rd 100, Beijing 100052, PR China
    BMC Infect Dis 10:86. 2010
    ..This study investigated the possible changes of tau and phosphorylated tau (p-tau, at Ser396, Ser404, and Ser202/Thr205) in scrapie experimental animals...
  64. ncbi Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models
    Nancy Gore Saravia
    Centro Internacional de Entrenamiento e Investigaciones Medicas CIDEIM, Apartado Aéreo 5390, Cali, Colombia
    Vaccine 24:4247-59. 2006
    ..These findings support the feasibility of using genetically attenuated live Leishmania to achieve protective immunity...
  65. pmc The polybasic N-terminal region of the prion protein controls the physical properties of both the cellular and fibrillar forms of PrP
    Valeriy G Ostapchenko
    Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
    J Mol Biol 383:1210-24. 2008
    ..This work also suggests that this region could regulate diversity of prion strains or subtypes despite its remote location from the prion folding domain...
  66. ncbi Kinetics of Taenia solium antibodies and antigens in experimental taeniosis
    Guillermina Avila
    Departamento de Microbiologia y Parasitologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, D F 04510, Mexico
    Parasitol Res 89:284-9. 2003
    ..This indicates, in addition, that the passage of T. solium antigens from the small intestine to the circulation was blocked...
  67. ncbi Beta-glucan fractions from barley and oats are similarly antiatherogenic in hypercholesterolemic Syrian golden hamsters
    Bryan Delaney
    Cargill Health and Food Technologies, Wayzata, MN 55391, USA
    J Nutr 133:468-75. 2003
    ..706, P < 0.0001, respectively), this association could explain only half of the variability. This study demonstrated that the cholesterol-lowering potency of beta-glucan is approximately identical whether its origin was oats or barley...
  68. pmc Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins
    K M Pan
    Department of Neurology, University of California, San Francisco 94143
    Proc Natl Acad Sci U S A 90:10962-6. 1993
    ..Since PrPSc seems to be the only component of the "infectious" prion particle, it is likely that this conformational transition is a fundamental event in the propagation of prions...
  69. pmc Transcriptional silencing of multiple genes in trophozoites of Entamoeba histolytica
    Rivka Bracha
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    PLoS Pathog 2:e48. 2006
    ..Silencing of other genes in G3 amoebae could provide a model to study their various functions. In addition, double gene-silenced, virulence-attenuated trophozoites may be an important tool in vaccine development...
  70. pmc Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau
    P L Lowrey
    Department of Neurobiology and Physiology, Howard Hughes Medical Institute, Northwestern University, Evanston, IL 60208, USA
    Science 288:483-92. 2000
    ..We conclude that tau is an allele of hamster CKIepsilon and propose a mechanism by which the mutation leads to the observed aberrant circadian phenotype in mutant animals...
  71. ncbi Standardization of an experimental model of human taeniosis for oral vaccination
    Sonia León-Cabrera
    Departamento de Microbiologia y Parasitologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, UNAM, Av Universidad 3000, Colonia Copilco Universidad, Mexico 04510 DF, Mexico
    Methods 49:346-50. 2009
    ..Protection was gained in 9month old hamsters, but not in 3month old animals...
  72. ncbi Proteophosphoglycan is differentially expressed in sodium stibogluconate-sensitive and resistant Indian clinical isolates of Leishmania donovani
    M Samant
    Divisions of Parasitology Central Drug Research Institute, Lucknow, India
    Parasitology 134:1175-84. 2007
    ..This study suggests the possibilities of involvement of PPG in drug-resistant mechanisms and of using PPG abundance as a marker for identifying drug-resistant clinical isolates in Indian kala azar...
  73. pmc Adenovirus vectors expressing hantavirus proteins protect hamsters against lethal challenge with andes virus
    David Safronetz
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Virol 83:7285-95. 2009
    ..These observations set the stage for a more detailed characterization of the types of immunity required to protect humans from hantavirus infections...
  74. pmc Expression of Period genes: rhythmic and nonrhythmic compartments of the suprachiasmatic nucleus pacemaker
    T Hamada
    Department of Psychology, Columbia University, New York, New York 10027, USA
    J Neurosci 21:7742-50. 2001
    ..These results reveal the occurrence of differential regulation of clock genes in two distinct SCN regions and suggest a potential mechanism for producing functional differences in distinct SCN subregions...
  75. ncbi Lysosomal depletion in macrophages from spleen and foot lesions of Leishmania-infected hamster
    C L Barbieri
    Department of Microbiology, Immunology and Parasitology, Escola Paulista de Medicina, Sao Paulo, Brasil
    Exp Parasitol 71:218-28. 1990
    ..These results provide evidence that the lysosomal depletion can occur at the ACP synthesis and/or glycosylation level...
  76. ncbi Leishmania tarentolae: utility as an in vitro model for screening of antileishmanial agents
    Viviana M Taylor
    PECET, School of Medicine, Universidad de Antioquia, Medellin, Colombia
    Exp Parasitol 126:471-5. 2010
    ..L. tarentolae amastigotes offer a suitable model for the in vitro screening of compounds for antileishmanial activity...
  77. ncbi Periodic variation in R-R intervals and cardiovascular autonomic regulation in young adult Syrian hamsters
    H Mongue-Din
    Institut de Myologie INSERM, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Am J Physiol Regul Integr Comp Physiol 296:R610-7. 2009
    ..Therefore, Syrian hamsters represent a unique model for HRV studies...
  78. ncbi Emphysema-induced reductions in locomotory skeletal muscle contractile function
    John P Mattson
    Department of Health and Excercise Science, Adolphus College, 212C Lund Center, 800 West College Avenue, Gustavus Adolphus College, St Peter, MN 56082, USA
    Exp Physiol 90:519-25. 2005
    ....
  79. pmc Real-time reverse transcription-PCR quantification of cytokine mRNA expression in golden Syrian hamster infected with Leishmania infantum and treated with a new amphotericin B formulation
    S Rama Iñiguez
    Departamento de Parasitologia, Facultad de Farmacia, Universidad Complutense, Plaza de Ramón y Cajal s n, Ciudad Universitaria, 28040 Madrid, Spain
    Antimicrob Agents Chemother 50:1195-201. 2006
    ..assay was developed for the quantification of cytokine mRNA expression in the golden Syrian hamster Mesocricetus auratus infected with Leishmania infantum and treated with amphotericin B (AMB) formulated in microspheres made ..
  80. ncbi Clinical laboratory, virologic, and pathologic changes in hamsters experimentally infected with Pirital virus (Arenaviridae): a rodent model of Lassa fever
    Elena Sbrana
    Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, 77555 0609, USA
    Am J Trop Med Hyg 74:1096-102. 2006
    ....
  81. pmc Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver
    Z Sheng
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas 75235
    Proc Natl Acad Sci U S A 92:935-8. 1995
    ....
  82. pmc Global proteome analysis of Leptospira interrogans
    Azad Eshghi
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada
    J Proteome Res 8:4564-78. 2009
    ..interrogans virulence factors...
  83. ncbi Complete nucleotide sequence of a Chilean hantavirus
    John D Meissner
    Department of Microbiology, University of Nevada, FA310 MS200, Reno, NV 89557, USA
    Virus Res 89:131-43. 2002
    ....
  84. ncbi Regulation of sterol regulatory element-binding proteins in hamster intestine by changes in cholesterol flux
    F J Field
    Department of Internal Medicine and Department of Veterans Affairs, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 276:17576-83. 2001
    ..Following marked changes in cholesterol flux across the intestine, SREBP-2 assumes the role of SREBP-1 and regulates both cholesterol and fatty acid synthesis in intestine...
  85. ncbi Sustained whole-body functional rescue in congestive heart failure and muscular dystrophy hamsters by systemic gene transfer
    Tong Zhu
    Department of Orthopedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Circulation 112:2650-9. 2005
    ....
  86. ncbi Dietary myristic acid modifies the HDL-cholesterol concentration and liver scavenger receptor BI expression in the hamster
    Carole Loison
    Laboratoire de Physiologie de la Nutrition laboratorie associé à l INRA, Universite Paris Sud, Centre d Orsay, France
    Br J Nutr 87:199-210. 2002
    ..The present investigation shows that myristic acid modulates HDL-cholesterol via a regulation of the SR-BI expression...
  87. ncbi Mammalian cerebral metabolism and amino acid neurotransmission during hibernation
    Peter G Osborne
    Baongong Agri Science Center, Taidong City, Taiwan
    J Neurochem 106:1888-99. 2008
    ..It is proposed that cerebral intracellular dehydration, the enlargement of ECF and the biochemistries associated with brain water homeostasis may have a role in regulating hibernation...
  88. ncbi Reduction of prion infectivity and levels of scrapie prion protein by lithium aluminum hydride: implications for RNA in prion diseases
    Byung Hoon Jeong
    Ilsong Institute of Life Science, Hallym University, Gyounggi do, South Korea
    J Neuropathol Exp Neurol 68:870-9. 2009
    ..Together, these data suggest that RNA molecules may be important for maintaining the structure of PrPSc and that oxidized molecules can be important in scrapie agent replication and prion infectivity...
  89. ncbi Memory for individuals: hamsters (Mesocricetus auratus) require contact to develop multicomponent representations (concepts) of others
    Robert E Johnston
    Department of Psychology, Cornell University, Ithaca, NY 14853, USA
    J Comp Psychol 122:121-31. 2008
    ..We are not aware of experimental proof for integrated, multicomponant memories in any other nonhuman species...
  90. pmc Insulin resistance in insulin-resistant and diabetic hamsters (Mesocricetus auratus) is associated with abnormal hepatic expression of genes involved in lipid and glucose metabolism
    Guosheng Li
    Department of Pathology, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences CAMS and Peking Union Medical College PUMC, Beijing, China
    Comp Med 59:449-58. 2009
    ..Expression of LXRalpha, SREBPs, and PPARalpha all change in FIHIR associated with hepatic lipid accumulation in insulin-resistant and diabetic hamsters in which disease is induced by high-fat diet and streptozotocin injection...
  91. ncbi Corticotropin-releasing factor type II (CRF-sub-2) receptors in the bed nucleus of the stria terminalis modulate conditioned defeat in Syrian hamsters (Mesocricetus auratus)
    Matthew A Cooper
    Department of Psychology and Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30302 3966, USA
    Behav Neurosci 119:1042-51. 2005
    In Syrian hamsters (Mesocricetus auratus), social defeat produces a subsequent increase in submissive and defensive behavior and a loss of normal territorial aggression, which the authors have called conditioned defeat...
  92. ncbi Strain-specific kinetics of prion protein formation in vitro and in vivo
    Ellyn R Mulcahy
    Department of Medical Microbiology and Immunology, Creighton University, Omaha, NE 68178, USA
    J Biol Chem 279:1643-9. 2004
    ..These results suggest that strain-specific conformations of PrP(Sc) have the ability to influence the rate of additional PrP(Sc) formation from cellular PrP both in vitro and in vivo...
  93. pmc A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions
    P C Klöhn
    Medical Research Council Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 100:11666-71. 2003
    ..SC assays performed in a more time-consuming end point titration format extend the sensitivity and show that infectivity titers measured in tissue culture and in the mouse are similar...
  94. ncbi Maximal force is unaffected by emphysema-induced atrophy in extensor digitorium longus
    J P Mattson
    Department of Health and Exercise Science, Gustavus Adolphus College, 800 West College Avenue, St Peter, MN 56082, USA
    Respir Physiol Neurobiol 161:119-24. 2008
    ..01). Surprisingly, maximal force was preserved in emphysema animals. These data demonstrate that maximal muscle force may be preserved in the face of emphysema-induced fiber atrophy...
  95. ncbi Leukemia inhibitory factor ligand-receptor signaling is important for uterine receptivity and implantation in golden hamsters (Mesocricetus auratus)
    Tianbing Ding
    Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, 1125 MRB IV Light Hall, 2215 B Garland Avenue, Nashville, TN 37232 0656, USA
    Reproduction 135:41-53. 2008
    ..Taken together, these data suggest that Lif signaling is important for uterine receptivity and implantation in hamsters...
  96. ncbi Functional and histopathological study of the pancreas in hamsters (Mesocricetus auratus) infected and reinfected with Trypanosoma cruzi
    Vitorino Modesto dos Santos
    Department of Internal Medicine, Faculdade de Medicina do Triangulo Mineiro, Uberaba, Minas Gerais, Brazil
    Parasitol Res 94:125-33. 2004
    ..Our findings favor the hypothesis of the existence of an endocrine form of chronic chagasic infection...
  97. ncbi Feeding differences in pubertal and aged golden hamsters (Mesocricetus auratus) are related to specific cerebral expression pattern of histamine subtype 3 receptor
    Maria Madeo
    Comparative Neuroanatomy Laboratory, Department of Ecology, University of Calabria, Arcavacata di Rende, Italy
    Behav Neurosci 120:1235-41. 2006
    The hibernating golden hamster (Mesocricetus auratus) is becoming a useful rodent model to study the neurophysiological role of some neuromediators on vital behaviors such as sleep and thermoregulation...
  98. ncbi Reconstitution of prion infectivity from solubilized protease-resistant PrP and nonprotein components of prion rods
    G M Shaked
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem 91120, Israel
    J Biol Chem 276:14324-8. 2001
    ..We submit that whereas PrP 27-30 is probably the obligatory template for the conversion of PrP(C) to PrP(Sc), sulfated sugar polymers may play an important role in the pathogenesis of prion diseases...
  99. ncbi Binocular contributions to the responsiveness and integrative capacity of the circadian rhythm system to light
    Louise Muscat
    Graduate Program in Neuroscience, Stony Brook University, NY 11794, USA
    J Biol Rhythms 20:513-25. 2005
    ..The mechanism of integration neither resides in the retina nor in the RHT...
  100. pmc Prion strain targeting independent of strain-specific neuronal tropism
    Jacob I Ayers
    Department of Medical Microbiology and Immunology, 2500 California Plaza, Omaha, Nebraska 68178, USA
    J Virol 83:81-7. 2009
    ..The data suggest that differences in PrP(Sc) distribution between strains during clinical disease are due to differences in the length of time that PrP(Sc) has to spread in the CNS before the host succumbs to disease...
  101. pmc Organization of suprachiasmatic nucleus projections in Syrian hamsters (Mesocricetus auratus): an anterograde and retrograde analysis
    Lance J Kriegsfeld
    Department of Psychology, Columbia University, New York, New York 10027, USA
    J Comp Neurol 468:361-79. 2004
    ....

Research Grants67

  1. ADOLESCENT ANABOLIC STEROIDS, VASOPRESSIN AND AGGRESSION
    Richard H Melloni; Fiscal Year: 2013
    ..In previous studies, we showed that pubertal male Syrian hamsters (Mesocricetus auratus) exposed to moderate doses of commonly used anabolic steroids display a high level of offensive ..
  2. Neurobiology of Social Behavior
    ELLIOTT ALBERS; Fiscal Year: 2005
    ..project will investigate the neural and endocrine mechanisms that control social behavior in Syrian hamsters (Mesocricetus auratus)...
  3. STUDIES ON MAMMALIAN OOCYTES (AND SPERMATOCYTES)
    GEORGIANA JAGIELLO; Fiscal Year: 1993
    ..The feasibility of the such studies has been demonstrated in a preliminary study with male Mesocricetus auratus.
  4. TASTE QUALITY REPRESENTATION IN THE SOLITARY NUCLEUS
    MARION FRANK; Fiscal Year: 1992
    ..the first central relay for taste in mammals, is being studied anatomically and physiologically in the hamster (Mesocricetus auratus) ...
  5. TEMPORAL INTEGRATION OF PHOTOPERIODIC SIGNALS IN MAMMALS
    Michael Gorman; Fiscal Year: 2002
    ..Prior studies have examined responses of Siberian, Phodopus sungorus, and Syrian hamsters, Mesocricetus auratus, to static long and short day lengths of early summer and winter, respectively...
  6. BRAIN MECHANISMS OF BEHAVIORAL DIMORPHISM
    C Carter; Fiscal Year: 1980
    ..Results of these studies to date indicate that neuronal growth in the hamster (Mesocricetus auratus) dorsomedial preoptic area (as measured by soma size changes and growth cones) reached a peak at 5 to ..
  7. Micellar VIP Nanoparticles for Rheumatoid Arthritis
    Israel Rubinstein; Fiscal Year: 2007
    ..abstract_text> ..
  8. Human Salty and Bitter Taste Mechanisms
    MARION FRANK; Fiscal Year: 2007
    ..Greater understanding of gustatory perceptual processing in humans may lead to better management of taste disorders such as distressful salty-bitter dysgeusias and excessive salt intake. ..
  9. PERIPHERAL GUSTATORY PROCESSING
    MARION ELIZABETH FRANK; Fiscal Year: 2010
    ..3 integrated behavioral, neurophysiological and genetic studies are proposed on golden hamsters (Mesocricetus auratus) and laboratory mice aimed at delineating the functioning of their sweet (attracting) and bitter (..
  10. Mechanisms of Stress-Induced Changes in Behavior
    Matthew Cooper; Fiscal Year: 2006
    ..The experiments in the current proposal will provide valuable information on the neurobiological mechanisms underlying stress-related disorders. [unreadable] [unreadable]..
  11. TEMPORAL INTEGRATION OF PHOTOPERIODIC SIGNALS IN MAMMALS
    Michael R Gorman; Fiscal Year: 2010
    ..Studies in this area have examined responses of Siberian, Phodopus sungorus, and Syrian hamsters, Mesocricetus auratus, exposed to static long and short day lengths of early summer and winter, respectively...
  12. NNK, Beta-Adrenergic AA Release and Lung Cancer
    HILDEGARD SCHULLER; Fiscal Year: 2005
    ..2. To determine which products of the AA cascade are formed in untreated cells and in response to NNK, which of these products stimulate DNA synthesis, and what downstream effectors are activated by these products. ..
  13. Mucosal Immune Responses in Hookworm Infection
    Richard Bungiro; Fiscal Year: 2006
    ..These studies are expected to further our understanding of host-parasite immunological interaction and advance hookworm vaccine research through the development of novel immunization techniques. ..
  14. The Role of Melanocortin 4 Receptors in Energy Balance
    JULI JONES; Fiscal Year: 2005
    ....
  15. Preclin. model for prevention of NSCLC in former smokers
    HILDEGARD SCHULLER; Fiscal Year: 2006
    ....
  16. MOLECULAR TOOLS TO DEVELOP HAMSTER MODELS OF DISEASE
    Peter Melby; Fiscal Year: 2003
    The Syrian hamster (Mesocricetus auratus) has unique features that make it advantageous for use as a model for a number of infectious, cardiopulmonary, inflammatory, and neoplastic diseases...
  17. R21: Entrainment of Peripheral Circadian Rhythms
    ERIC BITTMAN; Fiscal Year: 2008
    ..These studies will provide important new tools for analysis of the multi-oscillator system that governs normal physiological function and whose malfunction may contribute to disease. [unreadable] [unreadable] [unreadable]..
  18. 2008 Spirochetes Gordon Research Conference
    David Haake; Fiscal Year: 2008
    ..Funding from the National Institutes of Health is requested to partially offset the travel and registration expenses of the participating graduate students, fellows, and junior faculty members. ..
  19. Rapid Metabolic Control of the HPG System
    JILL SCHNEIDER; Fiscal Year: 2007
    ..Comparisons of species from two different taxa will test the generality of the conclusions. ..
  20. Mechanisms of ATP Release from RBC's
    Randy Sprague; Fiscal Year: 2007
    ..abstract_text> ..
  21. MECHANISMS OF LOCAL SYNAPTIC TRANSMISSION IN DORSAL HORN
    Stephen Schneider; Fiscal Year: 2007
    ..The studies will provide essential information about dynamic modulation of synaptic function underlying spinal integration of innocuous and noxious sensory information. ..
  22. Neurobiology of Social Attraction and Preference
    Aras Petrulis; Fiscal Year: 2009
    ..This data will provide novel insights into how sexual attraction and preference is generated by the nervous system and how sensory and internal state cues interact to regulate motivated behavior. ..
  23. Suprachiasmatic Control of Peripheral Circadian Rhythms
    ERIC BITTMAN; Fiscal Year: 2009
    ....
  24. Role of Erythrocytes in Circulatory Control
    Randy Sprague; Fiscal Year: 2004
    ..abstract_text> ..
  25. GROWTH FACTORS IN FOLLICULAR DEVELOPMENT
    Shyamal Roy; Fiscal Year: 2001
    ..The information will shed light on the mechanisms involved in hormonal control of folliculogenesis via intraovarian growth factors. ..
  26. A Rapid Immunoassay for Detection of Yersinia Pathogens
    John Glass; Fiscal Year: 2002
    ..Furthermore, this prototype assay will be reduced to a production model, validated for regulatory approval, and finalized for manufacture through a joint venture partner. ..
  27. NEURAL MECHANISMS RESETTING THE AGED CIRCADIAN PACEMAKER
    Marilyn J Duncan; Fiscal Year: 2010
    ....
  28. MOLECULAR MECHANISMS OF ESTROGEN INDUCED CARCINOGENESIS
    HARI BHAT; Fiscal Year: 2002
    ....
  29. VACCINATION OF DOGS TO REDUCE TRANSMISSION OF LEISHMANIA
    Peter Melby; Fiscal Year: 2003
    ..Successful vaccination of dogs in an endemic could reduce both enzootic (among the canine reservoir) and zoonotic (from the canine reservoir to humans) transmission. ..
  30. A CONFOCAL MICROSCOPE FOR NEUROBIOLGY
    Stephen Schneider; Fiscal Year: 2001
    ..Acquisition of the LSM 5 will significantly enhance the research programs of the major users and aid other investigators in the broader MSU research community. ..
  31. Optical imaging of neural activity in auditory system
    JAMES KALTENBACH; Fiscal Year: 2004
    ..The significance of these experiments is that they will yield information regarding the dynamics of signal processing and reveal new aspects of DCN circuitry that have been difficult to study electrophysiologically. ..
  32. NOS2 and arginase in visceral leishmaniasis
    Peter Melby; Fiscal Year: 2009
    ..These studies in the hamster will fill a knowledge gap by defining mechanisms of disease and immunity that are strikingly different from those of the murine model. ..
  33. NEURAL MECHANISMS OF SOCIAL RECOGNITION AND MEMORY
    Robert Johnston; Fiscal Year: 2009
    ..These mechanisms are essential building blocks in the social behavior of non-human animals and humans. ..
  34. NEURAL REGULATION OF CIRCADIAN RHYTHMS AND PHOTOPERIODIS
    ERIC BITTMAN; Fiscal Year: 2003
    ..Our results will have applications to human pathologies including jet lag, sleep disorders, seasonal depression, and infertility. ..
  35. The Chronobiology of Cohabitation
    Matthew Paul; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  36. PHARMACOGENETICS OF DRUG AND CARCINOGEN METABOLISM
    David Hein; Fiscal Year: 2009
    ..We also will assess the effect of NAT1 and NAT2 genotypes in breast cancer risk through participation in ongoing molecular epidemiology investigations of breast cancer in Shanghai China and in Nashville, Tennessee. ..
  37. Genomic Instability and Etiology of Estrogen Oncogenesis
    Jonathan Li; Fiscal Year: 2007
    ..abstract_text> ..
  38. Optical Imaging of Ovarian Carcinogenesis in a Rat Menopause Model
    Jennifer Kehlet Barton; Fiscal Year: 2011
    ..abstract_text> ..
  39. Feedback and Hormonal Regulation of Hepatic HMG-CoA Reductase
    GENE CHARLES NESS; Fiscal Year: 2010
    ....
  40. MOLECULAR ORIGIN OF CANCER--CATECHOL/SEMIQUINOE/QUINONE
    Ercole Cavalieri; Fiscal Year: 2003
    ..In addition, we will identify biomarkers for use in diagnosis and in studies of prevention of breast cancer and other diseases. ..
  41. 5th International Symposium on Hormonal Carcinogenesis
    Jonathan Li; Fiscal Year: 2006
    ..Area 4: Hormone Dependency and Independency. e) In prostate, breast and uterine cancer, Session 6. As in the past, a book will be published of the presentations. [unreadable] [unreadable] [unreadable] [unreadable]..
  42. TWILIGHTS AND CIRCADIAN ENTRAINMENT
    Ziad Boulos; Fiscal Year: 2001
    ..Thus, a systematic account of twilight-induced effects on circadian entrainment may provide the basis for refined clinical treatments of sleep phase and seasonal affective disorder. ..
  43. WORLD REFERENCE CENTER FOR ARBOVIRUSES
    Robert Tesh; Fiscal Year: 2002
    ..abstract_text> ..
  44. STRAIN PROPERTIES OF THE PRION PROTEIN
    Jason Bartz; Fiscal Year: 2002
    ..For each of the aims, the hyper (HY) and drowsy (DY) strains of transmissible mink encephalopathy (TME) will be examined in order to determine the role of strain-specific PrP-res in the neuropathogenesis of strain diversity. ..
  45. Circadian Rhythms: Photic Sensitivity and Behavior
    Roberto Refinetti; Fiscal Year: 2003
    ..abstract_text> ..
  46. Pathogenesis of a novel Hantavirus from laboratory rats
    JOE SIMMONS; Fiscal Year: 2003
    ..abstract_text> ..
  47. 4th International Symposium on Hormonal Carcinogenesis
    Jonathan Li; Fiscal Year: 2003
    ..abstract_text> ..
  48. Molecular Orgin Cancer--Catechol Estrogen 3 4 Quinones
    Ercole Cavalieri; Fiscal Year: 2004
    ..The knowledge acquired from these studies will be essential for developing preventive strategies. ..
  49. Neuroendocrine mechanisms of emotional behavior
    AARON JASNOW; Fiscal Year: 2004
    ..These data will contribute to our knowledge of the hormonal mechanisms underlying fear and anxiety. ..
  50. UTERINE DISRUPTION: DNA METHYLATION & EPITHELIA-STROMA
    WILLIAM HENDRY; Fiscal Year: 2005
    ..It should also yield important new insight into the topic of 'endocrine disruption'. ..
  51. Imaging the vascular response to implants
    Jennifer Barton; Fiscal Year: 2006
    ..This aim includes developing miniature probes for intravascular and external use, increasing acquisition speed, and performing signal and image processing to measure perfusion, shear rate, and tissue image texture. ..
  52. Epidemiology of Yellow Fever in the Americas
    Robert Tesh; Fiscal Year: 2005
    ..Most of the work will be done in laboratories at the University of Texas Medical Branch, Center for Tropical Diseases; but a small portion will be done at the Evandro Chagas Institute in Belem, Brazil. ..
  53. Steroid influences on brain maturation
    JULIA ZEHR; Fiscal Year: 2006
    ..A basic understanding of the processes controlling pubertal brain development provides a timely foundation for future studies of self-administered steroids, disease states, or environmental endocrine disrupters. ..
  54. Chronobiology of alcohol: animal models
    ALAN ROSENWASSER; Fiscal Year: 2006
    ..The results of these studies will contribute substantially to understanding both the causes and the consequences of sleep and circadian rhythm disruptions occurring in human alcoholics. ..
  55. Parallel OCT System for Endoscopic Imaging
    Jennifer Barton; Fiscal Year: 2004
    ..A series of studies will be performed to determine the value of OCT in distinguishing between normal bladder tissue, carcinoma in situ (Tis), and cancer confined to mucosa (Ta) lamina propria (Ti) and muscle (T2)...
  56. Mechanisms of prion transport
    RICHARD BESSEN; Fiscal Year: 2008
    ..These studies can determine the role of the olfactory nerve in centrifugal prion spread to the nasal mucosa where agent shedding is a potential route of prion transmission. ..
  57. HANTAVIRUS CELL INTERACTIONS
    ERICH MACKOW; Fiscal Year: 2003
    ..Specific Aims: 1) beta3 Integrin Requirements for Hantavirus Infectivity; 2) Blocking beta3 Integrin-Hantavirus Interactions; 3) Transgenic Model of Hantavirus Infection and Pathogenesis. ..
  58. ROTAVIRUS VP5 PERMEABILIZES MEMBRANES
    ERICH MACKOW; Fiscal Year: 2002
    ..These studies address an essential step in the rotavirus entry process and basic mechanisms by which non-enveloped viral proteins permeabilize cellular membranes during entry. ..
  59. Influenza PDZ Ligand Directed Pathogenesis
    ERICH MACKOW; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  60. Chemosensory Processing in Chemical Communication
    Michael Meredith; Fiscal Year: 2010
    ..The rodent amygdala uses circuits to analyze and classify chemosensory signals that have common features with circuits used by other species to analyze and classify other types of sensory stimuli. ..
  61. PKC-EHN-PKD signal complex in cardiac remodeling
    Masahiko Hoshijima; Fiscal Year: 2009
    ..abstract_text> ..
  62. Regulation of Circadian Activity Rhythms by Hypocretins
    Eric Mintz; Fiscal Year: 2002
    ..abstract_text> ..
  63. SPERM FUNCTION IN FERTILIZATION EVENTS
    Gary Olson; Fiscal Year: 2006
    ..3: To determine if eFGL binding to specific sperm ligands promotes sperm death and/or death cocoon polymerization.4: To define the function of eFGL by targeted disruption of the fgl2 gene in mice. ..
  64. Noninvasive Devices for fMRI Studies in Drug Abuse -II
    Craig Ferris; Fiscal Year: 2004
    ..This technology will greatly enhance preclinical research in developmental neurobiology, neurological diseases, mental illness and drug addiction. ..
  65. ANTIPSYCHOTIC DRUGS AND CORTICAL DEVELOPMENT
    Douglas O Frost; Fiscal Year: 2010
    ..Thus, our results can aid in the design of new therapies that improve clinical outcomes. ..
  66. Assessing nuclear morphology in thick tissues using fLCI
    Adam Wax; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..