guinea pigs

Summary

Summary: A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.

Top Publications

  1. pmc Noise overexposure alters long-term somatosensory-auditory processing in the dorsal cochlear nucleus--possible basis for tinnitus-related hyperactivity?
    Susanne Dehmel
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 32:1660-71. 2012
  2. pmc High temperature (30 degrees C) blocks aerosol but not contact transmission of influenza virus
    Anice C Lowen
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 82:5650-2. 2008
  3. ncbi Iontophoresis in vivo demonstrates a key role for GABA(A) and glycinergic inhibition in shaping frequency response areas in the inferior colliculus of guinea pig
    F E LeBeau
    Department of Physiological Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Neurosci 21:7303-12. 2001
  4. pmc Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N
    John Steel
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
    PLoS Pathog 5:e1000252. 2009
  5. pmc Aerosol transmission of influenza A virus: a review of new studies
    Raymond Tellier
    Provincial Laboratory for Public Health of Alberta, Calgary, Canada
    J R Soc Interface 6:S783-90. 2009
  6. pmc A differentially amplified motion in the ear for near-threshold sound detection
    Fangyi Chen
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, USA
    Nat Neurosci 14:770-4. 2011
  7. pmc Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates
    Laura E Via
    Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20852, USA
    Infect Immun 76:2333-40. 2008
  8. pmc Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host
    Yuwei Gao
    Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People s Republic of China
    PLoS Pathog 5:e1000709. 2009
  9. pmc A comparative immunogenicity study of HIV-1 virus-like particles bearing various forms of envelope proteins, particles bearing no envelope and soluble monomeric gp120
    Emma T Crooks
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    Virology 366:245-62. 2007
  10. pmc Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosis
    Diane Ordway
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Clin Vaccine Immunol 15:1248-58. 2008

Detail Information

Publications298 found, 100 shown here

  1. pmc Noise overexposure alters long-term somatosensory-auditory processing in the dorsal cochlear nucleus--possible basis for tinnitus-related hyperactivity?
    Susanne Dehmel
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 32:1660-71. 2012
    ..time in vivo long-term effects of somatosensory inputs on acoustically evoked discharges of DCN neurons in guinea pigs. The effects of trigeminal nucleus stimulation are compared between normal-hearing animals and animals ..
  2. pmc High temperature (30 degrees C) blocks aerosol but not contact transmission of influenza virus
    Anice C Lowen
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 82:5650-2. 2008
    ..Our data imply that contact or short-range spread predominates in the tropics and offer an explanation for the lack of a well-defined, recurrent influenza season affecting tropical and subtropical regions of the world...
  3. ncbi Iontophoresis in vivo demonstrates a key role for GABA(A) and glycinergic inhibition in shaping frequency response areas in the inferior colliculus of guinea pig
    F E LeBeau
    Department of Physiological Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Neurosci 21:7303-12. 2001
    ....
  4. pmc Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N
    John Steel
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
    PLoS Pathog 5:e1000252. 2009
    ..Thus, our data show that PB2 amino acids 627 and 701 are determinants of mammalian inter-host transmission in diverse virus backgrounds...
  5. pmc Aerosol transmission of influenza A virus: a review of new studies
    Raymond Tellier
    Provincial Laboratory for Public Health of Alberta, Calgary, Canada
    J R Soc Interface 6:S783-90. 2009
    ..These recent results and their implication for infection control of influenza are discussed in this review...
  6. pmc A differentially amplified motion in the ear for near-threshold sound detection
    Fangyi Chen
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, USA
    Nat Neurosci 14:770-4. 2011
    The ear is a remarkably sensitive pressure fluctuation detector. In guinea pigs, behavioral measurements indicate a minimum detectable sound pressure of ∼20 μPa at 16 kHz. Such faint sounds produce 0...
  7. pmc Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates
    Laura E Via
    Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20852, USA
    Infect Immun 76:2333-40. 2008
    ..Thus, three independent lines of evidence support the hypothesis that hypoxic microenvironments are an important feature of some lesions in these animal models of tuberculosis...
  8. pmc Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host
    Yuwei Gao
    Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People s Republic of China
    PLoS Pathog 5:e1000709. 2009
    ..The genetic basis for H5N1 viral transmission among humans is largely unknown. In this study, we used guinea pigs as a mammalian model to study the transmission of six different H5N1 avian influenza viruses...
  9. pmc A comparative immunogenicity study of HIV-1 virus-like particles bearing various forms of envelope proteins, particles bearing no envelope and soluble monomeric gp120
    Emma T Crooks
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    Virology 366:245-62. 2007
    ..the potential of native Envelope glycoprotein (Env) trimers as neutralizing antibody vaccines, we immunized guinea pigs with three types of VLPs and soluble gp120...
  10. pmc Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosis
    Diane Ordway
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Clin Vaccine Immunol 15:1248-58. 2008
    ..to monitor changes in cell populations accumulating in the lungs and lymph nodes of naïve and vaccinated guinea pigs challenged by low-dose aerosol infection with virulent Mycobacterium tuberculosis...
  11. pmc Transmission of influenza virus via aerosols and fomites in the guinea pig model
    Samira Mubareka
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Infect Dis 199:858-65. 2009
    ..The data provide new and much-needed insights into the modes of influenza virus spread and strain-specific differences in the efficiency of transmission...
  12. pmc Role of the dosR-dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models
    Paul J Converse
    Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Infect Immun 77:1230-7. 2009
    ..deletion mutant (DeltadosR-dosS [DeltadosR-S]), a dosR-complemented strain, and wild-type H37Rv in rabbits, guinea pigs, and mice infected by the aerosol route and in a mouse hollow-fiber model that may mimic in vivo granulomatous ..
  13. ncbi Treatment of Argentine hemorrhagic fever
    Delia A Enria
    Instituto Nacional de Enfermedades Virales Humanas, Dr Julio I Maiztegui, Monteagudo 2510, 2700 Pergamino, Argentina
    Antiviral Res 78:132-9. 2008
    ..Immune immunoglobulin or monoclonal antibodies should also be considered. New therapeutic options such as those being developed for systemic inflammatory syndromes should also be valuated in severe forms of AHF...
  14. ncbi Development of vaccines toward the global control and eradication of foot-and-mouth disease
    Luis L Rodriguez
    Agricultural Research Service, United States Department of Agriculture, Foreign Animal Disease Research Unit, Orient Point, New York, NY, USA
    Expert Rev Vaccines 10:377-87. 2011
    ..Furthermore, there is a need for better integrated strategies that fit the specific needs of endemic regions. Availability of these critical components will greatly enhance the chances for the global control and eradication of FMDV...
  15. pmc Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys
    Wendelien B Oswald
    Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS Pathog 3:e9. 2007
    ..This antibody was previously shown to fully protect guinea pigs from infection...
  16. ncbi Spatial representation of corticofugal input in the inferior colliculus: a multicontact silicon probe approach
    S C Bledsoe
    Kresge Hearing Research Institute, Dept of Otolaryngology, University of Michigan, 1301 E Ann St, Ann Arbor, MI 48109, USA
    Exp Brain Res 153:530-42. 2003
    ..Our goal was to study the properties and spatial representation of corticofugal input in the IC of guinea pigs with a high degree of spatial resolution...
  17. pmc Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy
    Jin Hyen Baek
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland 20892, USA
    J Clin Invest 122:1444-58. 2012
    ..Hb sequestration by Hp might therefore be a therapeutic modality for enhancing transfusion safety in severely ill or massively transfused patients...
  18. pmc Energetic performance is improved by specific activation of K+ fluxes through K(Ca) channels in heart mitochondria
    Miguel A Aon
    The Johns Hopkins University, School of Medicine, Institute of Molecular Cardiobiology, 720 Rutland Ave, 1060 Ross Bldg, Baltimore, MD 21205 2195, USA
    Biochim Biophys Acta 1797:71-80. 2010
    ..The results indicate that activating K+ flux through mitoK(Ca) mediates a beneficial effect on energetics that depends on mitochondrial swelling with maintained DeltaPsi(m)...
  19. pmc Encoding of the cough reflex in anesthetized guinea pigs
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Regul Integr Comp Physiol 300:R369-77. 2011
    ..These attributes may have direct relevance to the presentation of cough in disease and for the effectiveness of antitussive therapies...
  20. pmc Oral infection with signature-tagged Listeria monocytogenes reveals organ-specific growth and dissemination routes in guinea pigs
    Jody A Melton-Witt
    Department of Molecular and Cell Biology, University of California, Berkeley, California, USA
    Infect Immun 80:720-32. 2012
    ..In this study we used 20 signature-tagged wild-type clones of L. monocytogenes in guinea pigs in combination with extensive quantitative data analysis to gain insight into extraintestinal dissemination...
  21. ncbi Genomic RNA editing and its impact on Ebola virus adaptation during serial passages in cell culture and infection of guinea pigs
    Valentina A Volchkova
    Filovirus Laboratory, INSERM U758, Human Virology Department, Universite de Lyon, Claude Bernard Université Lyon 1, Ecole Normale Superieure de Lyon, France
    J Infect Dis 204:S941-6. 2011
    ..EBOV/8U outgrows and eventually replaces the wild-type EBOV during 4-5 passages. On the contrary, infection of guinea pigs with EBOV/8U leads to the appearance and rapid predominance by EBOV/7U...
  22. pmc Evaluation of standard chemotherapy in the guinea pig model of tuberculosis
    Diane J Ordway
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Antimicrob Agents Chemother 54:1820-33. 2010
    ..Second, given the similarities of the pathology of disease in guinea pigs and humans, we wished to evaluate additional parameters, including magnetic resonance imaging, microscopy, and ..
  23. ncbi Representation of species-specific vocalizations in the inferior colliculus of the guinea pig
    Daniel Suta
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic
    J Neurophysiol 90:3794-808. 2003
    ..calls (purr, chutter, chirp, and whistle) were recorded in the inferior colliculus (IC) of anesthetized guinea pigs. All calls elicited a response in about 80% of units...
  24. pmc The guinea pig as a transmission model for human influenza viruses
    Anice C Lowen
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1124, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 103:9988-92. 2006
    ..Using the recent human isolate A/Panama/2007/99 (Pan/99) (H3N2) virus, we found that guinea pigs were highly susceptible to infection with the unadapted virus (ID(50) = 5 plaque-forming units)...
  25. ncbi A spike-timing code for discriminating conspecific vocalizations in the thalamocortical system of anesthetized and awake guinea pigs
    Chloé Huetz
    Laboratoire de Neurobiologie de l Apprentissage, de la Memoire et de la Communication, Unite Mixte de Recherche, Centre National de la Recherche Scientifique 8620, Universite Paris Sud, Orsay, France
    J Neurosci 29:334-50. 2009
    ..and auditory thalamus (n = 135) of anesthetized animals as well as in the auditory cortex (n = 119) of awake guinea pigs during presentation of four conspecific vocalizations...
  26. pmc Effective post-exposure treatment of Ebola infection
    Heinz Feldmann
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS Pathog 3:e2. 2007
    ....
  27. pmc Leptospirosis
    P N Levett
    University of the West Indies, School of Clinical Medicine and Research, and Leptospira Laboratory, Ministry of Health, Barbados
    Clin Microbiol Rev 14:296-326. 2001
    ....
  28. pmc Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910
    Anne J Lenaerts
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Antimicrob Agents Chemother 51:3338-45. 2007
    ..To date, the exact location of these persisting bacteria is not known. Lung lesions in guinea pigs infected with M...
  29. pmc A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses
    Hua Xin Liao
    Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA
    Virology 353:268-82. 2006
    ..Our study also shows the feasibility of iterative improvements in Env immunogenicity by rational design of centralized genes...
  30. ncbi Identification and characterization of the enzymatic activity of zeta-crystallin from guinea pig lens. A novel NADPH:quinone oxidoreductase
    P V Rao
    Laboratory of Mechanisms of Ocular Diseases, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 267:96-102. 1992
    zeta-Crystallin is a major protein in the lens of certain mammals. In guinea pigs it comprises 10% of the total lens protein, and it has been shown that a mutation in the zeta-crystallin gene is associated with autosomal dominant ..
  31. ncbi Multisensory integration in the dorsal cochlear nucleus: unit responses to acoustic and trigeminal ganglion stimulation
    S E Shore
    Kresge Hearing Research Institute and Department of Otolaryngology, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109, USA
    Eur J Neurosci 21:3334-48. 2005
    ..A bipolar stimulating electrode was placed into the trigeminal ganglion of anesthetized guinea pigs using stereotaxic co-ordinates...
  32. ncbi Representation of the purr call in the guinea pig primary auditory cortex
    Mark N Wallace
    MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD, UK
    Hear Res 204:115-26. 2005
    b>Guinea pigs produce the low-frequency purr or rumble call as an alerting signal. A digitised example of the call was presented to anaesthetised guinea pigs via a closed sound system while recording from the primary auditory cortex...
  33. pmc Individual and bivalent vaccines based on alphavirus replicons protect guinea pigs against infection with Lassa and Ebola viruses
    P Pushko
    Virology Division, United States Army Medical Research Institute for Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, USA
    J Virol 75:11677-85. 2001
    ..For vaccinations, the recombinant replicons were incorporated into virus-like replicon particles. Guinea pigs vaccinated with particles expressing Lassa virus nucleoprotein or glycoprotein genes were protected from lethal ..
  34. ncbi Representation of species-specific vocalizations in the medial geniculate body of the guinea pig
    Daniel Suta
    Department of Auditory Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, Prague, Czech Republic
    Exp Brain Res 183:377-88. 2007
    ..purr, chutter, chirp and whistle) in the ventral part of the medial geniculate body (MGB) of anesthetized guinea pigs. The neuronal and population peristimulus time histograms (PSTHs) reflected the repetition frequency of ..
  35. ncbi Animal models of highly pathogenic RNA viral infections: hemorrhagic fever viruses
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 78:79-90. 2008
    ..Such models are sufficient for testing of drugs that directly block viral replication, but may be inadequate for evaluating therapies that depend for their success on the activation or inhibition of host responses...
  36. pmc Agonist-evoked Ca(2+) wave progression requires Ca(2+) and IP(3)
    John G McCarron
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, John Arbuthnott Building, Glasgow, UK
    J Cell Physiol 224:334-44. 2010
    ..Together, these results suggest that waves initiate over a surprisingly large length of the cell and that both IP(3) and Ca(2+) are required for active propagation of the wave front to occur...
  37. pmc Caspase-3 contributes to ZO-1 and Cl-5 tight-junction disruption in rapid anoxic neurovascular unit damage
    Christoph M Zehendner
    Institute of Physiology and Pathophysiology, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany
    PLoS ONE 6:e16760. 2011
    ..In this study we elucidated the impact of acute cerebral ischemia on TJ protein arrangement and the role of the apoptotic effector protease caspase-3 in this context...
  38. ncbi Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD
    T Pera
    Department of Molecular Pharmacology, University Centre for Pharmacy, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Eur Respir J 38:789-96. 2011
    ..To this aim, guinea pigs were instilled intranasally with lipopolysaccharide (LPS) twice weekly for 12 weeks and were treated, by ..
  39. ncbi Increased arginase activity contributes to airway remodelling in chronic allergic asthma
    H Maarsingh
    Department of Molecular Pharmacology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Eur Respir J 38:318-28. 2011
    ..Ovalbumin-sensitised guinea pigs were treated with ABH or PBS via inhalation before each of 12 weekly allergen or saline challenges, and indices ..
  40. pmc Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic Fever
    Michelle Mendenhall
    Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, United States of America
    PLoS Negl Trop Dis 5:e1342. 2011
    ..At present, ribavirin is the only antiviral drug indicated for use in treatment of these diseases, but because of its limited efficacy in advanced cases of disease and its toxicity, safer and more effective antivirals are needed...
  41. pmc Somatosensory inputs modify auditory spike timing in dorsal cochlear nucleus principal cells
    Seth D Koehler
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Eur J Neurosci 33:409-20. 2011
    ..These changes likely occur through synaptic modulation of intrinsic excitability or synaptic inhibition...
  42. ncbi Blockade of neutrophil responses in aspiration pneumonia via ELR-CXC chemokine antagonism does not predispose to airway bacterial outgrowth
    Xixing Zhao
    Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Canada
    Pulm Pharmacol Ther 23:22-8. 2010
    ..b>Guinea pigs (n=5) were challenged intranasally with saline, acidified saline or acidified gastric contents (35mg/kg body ..
  43. ncbi Pharmacological basis for the medicinal use of black pepper and piperine in gastrointestinal disorders
    Malik Hassan Mehmood
    Natural Product Research Division, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi, Pakistan
    J Med Food 13:1086-96. 2010
    ....
  44. pmc Membrane cholesterol modulates cochlear electromechanics
    William E Brownell
    Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Pflugers Arch 461:677-86. 2011
    ..The enhanced electromechanical response reflects an increase in outer hair cell electromotility and may reveal features of cholesterol distribution and trafficking in outer hair cells...
  45. pmc Pre- and postexposure prophylaxis of Ebola virus infection in an animal model by passive transfer of a neutralizing human antibody
    Paul W H I Parren
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:6408-12. 2002
    A neutralizing human monoclonal antibody, KZ52, protects guinea pigs from lethal Ebola Zaire virus challenge. Administration before or up to 1 h after challenge resulted in dose-dependent protection by the antibody...
  46. ncbi Metabolic profiling of lung granuloma in Mycobacterium tuberculosis infected guinea pigs: ex vivo 1H magic angle spinning NMR studies
    B S Somashekar
    Department of Microbiology, Immunology and Pathology, Colorado State University, Campus Delivery 1682, Fort Collins, Colorado 80523 1682, United States
    J Proteome Res 10:4186-95. 2011
    ..HRMAS NMR) directly to infected tissues, allowing us to study the development of tuberculosis granulomas in guinea pigs in an untargeted manner...
  47. pmc Broad neutralization of human immunodeficiency virus type 1 (HIV-1) elicited from human rhinoviruses that display the HIV-1 gp41 ELDKWA epitope
    Gail Ferstandig Arnold
    Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, NJ 08854 5638, USA
    J Virol 83:5087-100. 2009
    ..Immunization of guinea pigs with different chimeras, some boosted with ELDKWA-based peptides, elicited antibodies capable of neutralizing ..
  48. pmc Enhancing mitochondrial Ca2+ uptake in myocytes from failing hearts restores energy supply and demand matching
    Ting Liu
    Division of Cardiology, The Johns Hopkins University, Baltimore, MD, USA
    Circ Res 103:279-88. 2008
    ..We conclude that high [Na+]i (at levels observed in heart failure) has detrimental effects on mitochondrial bioenergetics, and this impairment can be prevented by inhibiting the mitochondrial Na+/Ca2+ exchanger...
  49. ncbi Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX
    Ashima Saxena
    Division of Biochemistry, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Biochem Pharmacol 81:164-9. 2011
    ..humans, we purified enzyme from Cohn fraction IV-4 paste and initiated safety and efficacy evaluations in mice, guinea pigs, and non-human primates...
  50. pmc Leptospira as an emerging pathogen: a review of its biology, pathogenesis and host immune responses
    Karen V Evangelista
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, USA
    Future Microbiol 5:1413-25. 2010
    ....
  51. ncbi Chemical composition and mechanisms underlying the spasmolytic and bronchodilatory properties of the essential oil of Nepeta cataria L
    Anwar H Gilani
    Drug Discovery and Natural Products Research Unit, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 121:405-11. 2009
    ..The study was aimed to investigate the chemical composition and pharmacological basis for traditional use of essential oil of Nepeta cataria L. (Limiaceae) (Nc.Oil) in gastrointestinal and respiratory disorders...
  52. pmc Assessment of Aspergillus fumigatus burden in pulmonary tissue of guinea pigs by quantitative PCR, galactomannan enzyme immunoassay, and quantitative culture
    Ana C Vallor
    The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229 3900, USA
    Antimicrob Agents Chemother 52:2593-8. 2008
    ..02). Confirmation of fungal tissue burden by two or more methods should provide a more precise account of the burden, allowing improved assessment of diagnostic and therapeutic strategies in invasive pulmonary aspergillosis...
  53. pmc Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function
    Caroline Bertram
    1Centre for Developmental Origins of Health and Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
    J Physiol 586:2217-29. 2008
    ..Pregnant guinea pigs were fed 70% of normal intake from gestational days 1-35 (early restriction; ER), or 36-70 (late restriction; ..
  54. ncbi Erythrocyte binding preference of 16 subtypes of low pathogenic avian influenza and 2009 pandemic influenza A (H1N1) viruses
    Witthawat Wiriyarat
    Faculty of Veterinary Science, Mahidol University, Nakhonpathom 73170, Thailand
    Vet Microbiol 146:346-9. 2010
    ..Moreover, the 2009 pandemic viruses did not agglutinate both horse and chicken erythrocytes. Our study concluded that goose and guinea pig erythrocytes are the best in HA assay for all subtypes of influenza viruses...
  55. ncbi Certain dietary carbohydrates promote Listeria infection in a guinea pig model, while others prevent it
    Tine Ebersbach
    National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, 2860 Soeborg, Denmark
    Int J Food Microbiol 140:218-24. 2010
    ..We studied the effect of five non-digestible carbohydrates on the resistance of guinea pigs to Listeria monocytogenes infections...
  56. ncbi Long-term oral administration of glucosamine or chondroitin sulfate reduces destruction of cartilage and up-regulation of MMP-3 mRNA in a model of spontaneous osteoarthritis in Hartley guinea pigs
    Shin Taniguchi
    Department of Orthopaedic Surgery, Nihon University School of Medicine, 30 1, Ohyaguchikami cho, Itabashi ku, Tokyo 173 8610, Japan
    J Orthop Res 30:673-8. 2012
    ..of glucosamine (GlcN) and chondroitin sulfate (CS) in a model of spontaneous osteoarthritis (OA) in Hartley guinea pigs. Three groups of female 3-week-old Hartley guinea pigs received GlcN, CS, and neither agent, respectively...
  57. ncbi Neural changes in the auditory cortex of awake guinea pigs after two tinnitus inducers: salicylate and acoustic trauma
    A J Noreña
    Universite de Provence, CNRS UMR 6149, Marseille, France
    Neuroscience 166:1194-209. 2010
    ..While the present study showed that both salicylate and noise trauma induced some changes of spontaneous activity in auditory cortex, none of these changes are interpretable in terms of potential neural correlate of tinnitus...
  58. ncbi Identification and localisation of auditory areas in guinea pig cortex
    M N Wallace
    MRC Institute of Hearing Research, University Park, Nottingham, UK
    Exp Brain Res 132:445-56. 2000
    ..Units in the small field (S) typically had higher thresholds and broader tuning to pure tones than AI, while units in the ventrorostral belt typically had longer onset latencies and gave more sustained responses than units in AI...
  59. pmc Changes in protein profiles of guinea pig sclera during development of form deprivation myopia and recovery
    Xiangtian Zhou
    School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Mol Vis 16:2163-74. 2010
    To investigate changes in protein profiles of posterior sclera in guinea pigs during development of form deprivation myopia and recovery.
  60. ncbi Use of quantitative real-time PCR for studying the dissemination of Leptospira interrogans in the guinea pig infection model of leptospirosis
    Kristel Lourdault
    Institut Pasteur, Unité de Biologie des Spirochètes, Paris, France
    J Med Microbiol 58:648-55. 2009
    ..of infection (intraperitoneal, conjunctival and subcutaneous inoculation) were used to establish disease in guinea pigs. The size and kinetics of leptospiral burdens in the blood and tissues of infected animals were determined over ..
  61. pmc Mutations abrogating VP35 interaction with double-stranded RNA render Ebola virus avirulent in guinea pigs
    Kathleen C Prins
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 84:3004-15. 2010
    ..In guinea pigs, the VP35 mutant virus revealed a complete loss of virulence...
  62. pmc The endocochlear potential depends on two K+ diffusion potentials and an electrical barrier in the stria vascularis of the inner ear
    Fumiaki Nin
    Division of Molecular and Cellular Pharmacology, Department of Pharmacology, and Department of Otolaryngology, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 105:1751-6. 2008
    ..Because the EP depends on two K(+) diffusion potentials and an electrical barrier in the stria vascularis, interference with any of these elements can interrupt hearing...
  63. pmc Dose-dependent activity of pyrazinamide in animal models of intracellular and extracellular tuberculosis infections
    Zahoor Ahmad
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Antimicrob Agents Chemother 55:1527-32. 2011
    ..doses against intracellular and extracellular Mycobacterium tuberculosis in chronically infected mice and guinea pigs, respectively. Antibiotics were given five times weekly for 4 weeks beginning 28 days after infection...
  64. pmc Co-expression of DevR and DevR(N)-Aph proteins is associated with hypoxic adaptation defect and virulence attenuation of Mycobacterium tuberculosis
    Shyamasree De Majumdar
    Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India
    PLoS ONE 5:e9448. 2010
    ..DevR regulon genes are powerfully induced in vivo implicating them in bacterial adaptation to host control strategies. A better understanding of DevR function will illumine the way for new strategies to control and treat tuberculosis...
  65. ncbi Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs
    Ying Lin
    Department of Otolaryngology and Head and Neck Surgery, Xijing Hospital, Xi an, China
    Neurosci Lett 487:12-6. 2011
    ..In the present study, we tested the hypothesis that acoustic damage in guinea pigs can be attenuated by the consumption of molecular hydrogen...
  66. ncbi Interleukin-15 enhance DNA vaccine elicited mucosal and systemic immunity against foot and mouth disease virus
    Xiao Wang
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing 100094, China
    Vaccine 26:5135-44. 2008
    ..Taken together, the results demonstrated that intranasal delivery of IL-15 as a mucosal adjuvant can enhance the antigen-specific mucosal and systemic immune responses, which may provide a protection against the FMDV initial infection...
  67. ncbi Synthesis of empty capsid-like particles of Asia I foot-and-mouth disease virus in insect cells and their immunogenicity in guinea pigs
    Yimei Cao
    Lanzhou Veterinary Research Institute of Chinese Academy of Agriculture Science, State Key Laboratory of Veterinary Etiological Biology, National Foot and mouth Disease Reference Laboratory, Yanchangpu, Lanzhou, Gansu, The People s Republic of China
    Vet Microbiol 137:10-7. 2009
    ..the empty capsid-like particles or intermediates induced high levels of FMDV-specific antibodies in guinea pigs following immunization, and neutralizing antibodies were induced in the second week after vaccination...
  68. pmc A live guinea pig cytomegalovirus vaccine deleted of three putative immune evasion genes is highly attenuated but remains immunogenic in a vaccine/challenge model of congenital cytomegalovirus infection
    Megan M Crumpler
    Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA, USA
    Vaccine 27:4209-18. 2009
    ..These results suggest that the safety and perhaps efficacy of live attenuated human cytomegalovirus vaccines could be enhanced by deletion of viral immunomodulatory genes...
  69. ncbi Evaluation of the antitussive effect of stigma and petals of saffron (Crocus sativus) and its components, safranal and crocin in guinea pigs
    Hossein Hosseinzadeh
    Pharmacology and Toxicology Department, Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR, Iran
    Fitoterapia 77:446-8. 2006
    ..and its components, safranal and crocin, was evaluated using the nebolized solution of citric acid 20% in guinea pigs. The extract and agents were injected intraperitoneally. The ethanolic extract of C...
  70. pmc Topographic spread of inferior colliculus activation in response to acoustic and intracochlear electric stimulation
    Russell L Snyder
    Epstein Laboratory, Department of Otolaryngology, University of California, San Francisco, CA 94143 0526, USA
    J Assoc Res Otolaryngol 5:305-22. 2004
    ..Bipolar stimulation with longitudinally oriented VP electrodes produced broad activation that tended to broaden as the separation between electrodes increased...
  71. pmc A reaction-diffusion model of ROS-induced ROS release in a mitochondrial network
    Lufang Zhou
    Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS Comput Biol 6:e1000657. 2010
    ..The work identifies the fundamental mechanisms leading from the failure of individual organelles to the whole cell, thus it has important implications for understanding cell death during the progression of heart disease...
  72. ncbi Isolated perfused and paced guinea pig heart to test for drug-induced changes of the QT interval
    Hsien C Cheng
    Safety Pharmacology, Drug Safety Evaluation, Sanofi Aventis, Bridgewater, NJ 08807, USA
    J Pharmacol Toxicol Methods 54:278-87. 2006
    ..Since QT intervals can be generated from paced or spontaneously beating hearts, data so generated can also be used for validating QT(c) correction equations...
  73. ncbi In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin
    Debbi MacMillan
    Institute of Biomedical and Life Sciences, Neuroscience and Biomedical Systems, West Medical Building, University of Glasgow, Glasgow, G12 8QQ, UK
    J Cell Sci 118:5443-51. 2005
    ..However, FKBP12 might indirectly modulate Ca2+ release through two effector proteins: (1) mTOR, which potentiates and (2) calcineurin, which inhibits Ca2+ release from IP3R in smooth muscle...
  74. pmc Comparative efficacy and immunogenicity of replication-defective, recombinant glycoprotein, and DNA vaccines for herpes simplex virus 2 infections in mice and guinea pigs
    Yo Hoshino
    Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland 20892, USA
    J Virol 79:410-8. 2005
    ..Moreover, latent dl5-29 virus could not be detected by PCR in sacral ganglia from guinea pigs vaccinated intravaginally...
  75. pmc Pathogenesis of XJ and Romero strains of Junin virus in two strains of guinea pigs
    Nadezhda E Yun
    Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555 1019, USA
    Am J Trop Med Hyg 79:275-82. 2008
    ..We compared the virulence of two Junin virus strains in inbred and outbred guinea pigs with the aim of characterizing this animal model better for future vaccine/antiviral efficacy studies...
  76. pmc Forward masking estimated by signal detection theory analysis of neuronal responses in primary auditory cortex
    Ana Alves-Pinto
    MRC Institute of Hearing Research, Science Road, University Park, Nottingham, Nottinghamshire, UK
    J Assoc Res Otolaryngol 11:477-94. 2010
    ..Masking was largely attributable to a reduction in the responses to the probe, rather than either a persistence of the masker responses or an increase in the variability of probe responses...
  77. pmc Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status
    Miguel A Aon
    Institute of Molecular Cardiobiology, Department of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    J Biol Chem 282:21889-900. 2007
    ..The results indicate that GSH/GSSG redox status governs the sequential opening of mitochondrial ion channels (IMAC before PTP) triggered by thiol oxidation in cardiomyocytes...
  78. pmc Transgenic BDNF induces nerve fiber regrowth into the auditory epithelium in deaf cochleae
    Seiji B Shibata
    Kresge Hearing Research Institute, Department of Otolaryngology, The University of Michigan, 1150 W Med Cntr Dr, Ann Arbor, MI 48109 5648, USA
    Exp Neurol 223:464-72. 2010
    ..This model also provides a general experimental stage for drawing nerve fibers into a tissue devoid of neurons, and studying the interaction between the nerve fibers and the tissue...
  79. pmc Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs
    Felicitas S Boretti
    Clinic for Small Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    J Clin Invest 119:2271-80. 2009
    ..Furthermore, guinea pigs administered exogenous Hp displayed decreased Hb-induced hypertension and oxidative toxicity to extravascular ..
  80. pmc Induction of HIV neutralizing antibodies against the MPER of the HIV envelope protein by HA/gp41 chimeric protein-based DNA and VLP vaccines
    Ling Ye
    Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 6:e14813. 2011
    ..Immunization of guinea pigs using the HA-C14S/gp41 DNA or VLP vaccines induced antibodies against the HIV gp41 as well as to a peptide ..
  81. pmc Copper resistance is essential for virulence of Mycobacterium tuberculosis
    Frank Wolschendorf
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 108:1621-6. 2011
    ..b>Guinea pigs responded to infection with Mtb by increasing the Cu concentration in lung lesions...
  82. ncbi Water-soluble Coenzyme Q10 formulation (Q-ter) promotes outer hair cell survival in a guinea pig model of noise induced hearing loss (NIHL)
    Anna Rita Fetoni
    Institute of Otolaryngology, School of Medicine, Catholic University of Rome, Largo F Vito 1, 00168 Rome, Italy
    Brain Res 1257:108-16. 2009
    ..These data confirm that solubility of Coenzyme Q(10) improves the ability of CoQ(10) in preventing oxidative injuries that result from mitochondrial dysfunction...
  83. ncbi Pharmacological basis for the use of Fumaria indica in constipation and diarrhea
    Anwar H Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 96:585-9. 2005
    ..These data indicate that the presence of cholinergic and CCB constituents in Fi.Cr may explain the respective traditional use of Fumaria indica in constipation and diarrhoea...
  84. ncbi Protective properties of idebenone in noise-induced hearing loss in the guinea pig
    Bruno Sergi
    Institute of Otolaryngology, School of Medicine, Catholic University, Rome, Italy
    Neuroreport 17:857-61. 2006
    ..Noise-induced hearing loss was induced by exposing guinea pigs to a continuous pure tone and idebenone was injected intraperitoneally 1 h before noise exposure and once daily ..
  85. ncbi Excitotoxicity, synaptic repair, and functional recovery in the mammalian cochlea: a review of recent findings
    R Pujol
    INSERM, Montpellier, France
    Ann N Y Acad Sci 884:249-54. 1999
    ..Human applications should follow, and a local (transtympanic) strategy against cochlear excitotoxicity may, in the near future, prove to be helpful in ischemic- or noise-induced sudden deafness, as well as in the related tinnitus...
  86. ncbi The presence of cholinomimetic and calcium channel antagonist constituents in Piper betle Linn
    A H Gilani
    Department of Physiology and Pharmacology, The Aga Khan University Medical College, Karachi, Pakistan
    Phytother Res 14:436-42. 2000
    ..It is suggested that some of the traditional uses of this plant may be explained on the basis of these activities...
  87. pmc The guinea pig as a model of infectious diseases
    Danielle J Padilla-Carlin
    School of Pharmacy, Division of Molecular Pharmaceutics, University of North Carolina, Chapel Hill, NC, USA
    Comp Med 58:324-40. 2008
    ..Furthermore, for diseases in which guinea pigs share parallel pathogenesis of disease with humans, they are potentially the best animal model for designing ..
  88. pmc TRPA1 agonists evoke coughing in guinea pig and human volunteers
    Mark A Birrell
    Respiratory Pharmacology Group, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Am J Respir Crit Care Med 180:1042-7. 2009
    ..Environmental irritants such as air pollution and cigarette smoke are thought to evoke cough by stimulating airway sensory nerves; however, how this occurs is not fully understood...
  89. pmc Clinical and pathologic changes in a guinea pig aerosol challenge model of acute Q fever
    K E Russell-Lodrigue
    Department of Veterinary Pathobiology, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    Infect Immun 74:6085-91. 2006
    ..b>Guinea pigs were given 10(1) to 10(6) organisms and evaluated for 28 days postinfection...
  90. ncbi Organ of Corti potentials and the motion of the basilar membrane
    Anders Fridberger
    Center for Hearing and Communication Research, Department of Clinical Neuroscience, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    J Neurosci 24:10057-63. 2004
    ..However, to achieve the sharp frequency tuning that characterizes the basilar membrane, additional mechanical processing must occur inside the organ of Corti...
  91. ncbi Quantification of solute entry into cochlear perilymph through the round window membrane
    A N Salt
    Department of Otolaryngology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hear Res 154:88-97. 2001
    ..This study demonstrates the basic processes by which substances are distributed in the cochlea and provides a foundation to understand how other applied substances will be distributed in the ear...
  92. ncbi Protective immune response of the capsid precursor polypeptide (P1) of foot and mouth disease virus type 'O' produced in Pichia pastoris
    V Balamurugan
    Molecular Virology Laboratory, Indian Veterinary Research Institute, Hebbal, Bangalore 560 024, India
    Virus Res 92:141-9. 2003
    ..Immunisation of Guinea pigs with recombinant P1 induced FMDV type O specific immune response...
  93. ncbi A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
    C K Stover
    PathoGenesis Corporation, Seattle, Washington 98119, USA
    Nature 405:962-6. 2000
    ..tuberculosis and promising oral activity in animal infection models. We conclude that nitroimidazopyrans offer the practical qualities of a small molecule with the potential for the treatment of tuberculosis...
  94. pmc Vaccination of guinea pigs with DNA encoding the mycobacterial antigen MPB83 influences pulmonary pathology but not hematogenous spread following aerogenic infection with Mycobacterium bovis
    Mark A Chambers
    TB Research Group, Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey, KT15 3NB, United Kingdom
    Infect Immun 70:2159-65. 2002
    ..encoding the mycobacterial antigens MPB83 and 85A to reduce lung pathology and prevent hematogenous spread in guinea pigs challenged with a low dose of aerosolized M. bovis...
  95. ncbi Low coherence interferometry of the cochlear partition
    Niloy Choudhury
    Biomedical Engineering, Oregon Health and Science University, 20000 NW Walker Road, Beaverton, OR 97006, United States
    Hear Res 220:1-9. 2006
    ..30 nm above a noise floor equivalent to 0.03 nm. OCT interferometry, when adapted for in vivo organ of Corti measurements, appears suitable to determine the micromechanical vibration of cells and tissue elements of the organ...
  96. ncbi Evolution of foamy macrophages in the pulmonary granulomas of experimental tuberculosis models
    Neus Caceres
    Department of Microbiology, Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Catalonia, Spain
    Tuberculosis (Edinb) 89:175-82. 2009
    ..It is our hypothesis that the accumulation of lipids in M. tuberculosis concomitant to the establishment of the non-replicating state prepares the bacilli for future reactivation and for facing future stressful environments...
  97. ncbi Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, Mycobacterium tuberculosis in the guinea pig
    Zahoor Ahmad
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21289, USA
    J Infect Dis 200:1136-43. 2009
    ..We studied the anti-TB activity of isoniazid and its ability to select for drug-resistant mutant strains in guinea pigs, in which the histopathology of TB closely resembles that of human TB...
  98. pmc Imaging hair cell transduction at the speed of sound: dynamic behavior of mammalian stereocilia
    Anders Fridberger
    Center for Hearing and Communication Research, Department of Clinical Neuroscience, Karolinska Institutet, M1 Karolinska Universitetssjukhuset, SE 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 103:1918-23. 2006
    ..In the case of the inner hair cells, this finding would represent a departure from traditional views on their function...
  99. ncbi The demonstration of nitric oxide in cochlear blood vessels in vivo and in vitro: the role of endothelial nitric oxide in venular permeability
    Xiaorui Shi
    Oregon Hearing Research Center NRC04, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Hear Res 172:73-80. 2002
    ..The findings demonstrate the presence of endothelial NO in the cochlear blood vessels and suggest that NO protects cochlear venules against excessive vascular leakage...
  100. ncbi Monovalent virus-like particle vaccine protects guinea pigs and nonhuman primates against infection with multiple Marburg viruses
    Dana L Swenson
    US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD 21702 5011, USA
    Expert Rev Vaccines 7:417-29. 2008
    ..b>Guinea pigs vaccinated with Marburg virus VLPs (mVLPs) or inactivated MARV (iMARV) develop homologous humoral and T-cell ..
  101. ncbi Unilateral and bilateral projections from cortical cells to the inferior colliculus in guinea pigs
    Diana L Coomes
    Department of Anatomical Sciences and Neurobiology, University of Louisville, 500 S Preston Street, Louisville, KY 40202, USA
    Brain Res 1042:62-72. 2005
    ..4% on average). Unilaterally projecting cells are well positioned to have effects limited to one IC, whereas bilaterally projecting cells are likely to have a broader influence and may coordinate activity on the two sides of the midbrain...

Research Grants72

  1. Antiarrhythmic Mechanisms in the Hearts of Hibernating Mammals
    Lai Hua Xie; Fiscal Year: 2013
    ..DAD), and triggered activity (TA), and has been suggested as a potential proarrhythmic factor in rats, guinea pigs, and rabbits...
  2. N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus Infecti
    Aquilur Rahman; Fiscal Year: 2013
    ..herpes and pox viruses and drug-resistant variants in vivo at doses that are non-cytotoxic in mice, rats, guinea pigs and dogs, even at doses 1000-fold higher than the therapeutic dose...
  3. Screening Complete TB Proteome for Protective Antigens
    Alan Greener; Fiscal Year: 2010
    ..proteins to create protein arrays for subsequent immunological screening using material from Mtb-infected mice, guinea pigs, and human TB patients to select vaccine antigen candidates: Vaccine candidates identified by the T cell assays ..
  4. DlaT as a transcriptional regulator in non-replicating Mycobacterium tuberculosis
    Ruslana Bryk; Fiscal Year: 2012
    ..this pathway for the following reasons: DlaT is required for Mtb's full virulence in mice and survival in guinea pigs;dlaT's chromosomal location outside the PDH operon suggests a function unrelated to coordinate expression ..
  5. Effect Ultraviolet Radiation on Latent M. tuberculosis Infection in Guinea Pigs
    Amminikutty Jeevan; Fiscal Year: 2010
    ..the effect of UVR on persistent infection by examining the number of viable bacteria in the organs of infected guinea pigs and the cytokine and chemokine responses in lung granulomas by laser capture microdissection and real-time RT-..
  6. Visualization of ototoxic mitochondrial dysfunction in mammalian hair cells
    Shelley A Batts; Fiscal Year: 2012
    ..mitochondrial dysfunction in hair cell apoptosis, I will use fluorescence microscopy techniques in adult guinea pigs in vivo and in postnatal rat cochlear cultures in vitro...
  7. Novel Bacillus subtilis based spore vaccine to tuberculosis
    Subramanian Dhandayuthapani; Fiscal Year: 2013
    ..antigenic proteins Ag85B and ESAT- 6, when used together, can elicit protective immune responses in mice, guinea pigs and nonhuman primates...
  8. Development of an effective genital herpes vaccine
    William P Halford; Fiscal Year: 2010
    ..in human clinical trials if a live HSV-2 vaccine strain proves to be safe and effective in protecting mice, guinea pigs, rabbits, and hamsters against genital herpes...
  9. Microneedle-based immunization against pandemic influenza
    Mark R Prausnitz; Fiscal Year: 2011
    ..and DNA vaccines against the H5 influenza strain will be delivered using microneedles to mice and hairless guinea pigs. Microneedle design and vaccination protocol will be optimized based on measuring humoral immune responses, ..
  10. Recombinant life attenuated vaccine against Argentine hemorrhagic fever
    Slobodan Paessler; Fiscal Year: 2013
    ..2. To determine the safety, immunogenicity and efficacy of rJUNV/Candid1cSD in guinea pigs. We propose to conduct a comprehensive assessment of the virulence of our genetically well-defined MVS ..
  11. Mycobacterium tuberculosis carbon metabolism in vivo
    John D McKinney; Fiscal Year: 2010
    ..of the glcB mutant will be attenuated in ex vivo-infected macrophages and in aerosol-infected mice and guinea pigs. We predict that the glcB mutant will be unable to grow on fatty acids in vitro and will be killed by them...
  12. Development of a Novel Vaccine Against Herpes Simplex Type 2
    DEBORAH SPECTOR; Fiscal Year: 2009
    ..In Specific Aim 3, we will test in guinea pigs whether the DNA mediated protection can be augmented by subsequent boosting with a novel combination of whole, ..
  13. Developmental neurotoxicity of sarin and soman in guinea pigs
    Edson X Albuquerque; Fiscal Year: 2012
    ..disease, emerged as an effective antidote against acute OP poisoning in neonatal, prepubertal, and adult guinea pigs. Treatment with galantamine was also shown to counteract the cognitive deficits and anxiety-like behavior seen ..
  14. BETA ENDORPHIN NEURONS AND THE CONTROL OF HOMEOSTASIS
    Martin Kelly; Fiscal Year: 2009
    ..of principle, in vivo treatment with STX, similar to E2, attenuates the weight gain in hypo-estrogenic female guinea pigs. Although it is known that leptin and insulin inputs to POMC and neuropeptide Y (NPY) neurons are important for ..
  15. BETA ENDORPHIN NEURONS AND THE CONTROL OF HOMEOSTASIS
    MARTIN JEFFREY KELLY; Fiscal Year: 2013
    ..of principle, in vivo treatment with STX, similar to E2, attenuates the weight gain in hypo-estrogenic female guinea pigs. Although it is known that leptin and insulin inputs to POMC and neuropeptide Y (NPY) neurons are important for ..
  16. The Effects of Fatty Acid Ethyl Esters on the Developing Lung
    SOWMYA S MOHAN; Fiscal Year: 2010
    ..These hypotheses will be examined by performing various experiments on in utero ETOH-exposed preterm guinea pigs and control animals...
  17. Mycobacterial Dissemination and Persistence
    Jeffrey D Cirillo; Fiscal Year: 2010
    ..Mtb genes involved in hematogenous spread from the lung, 2) detailed comparison of dissemination in mice and guinea pigs, and 3) dissect the molecular mechanisms by which the mel2 locus affects dissemination and persistence...
  18. Neurotoxicity of organophosphorus pesticides in developing guinea pigs
    William Randall; Fiscal Year: 2013
    ..designed to test the central hypothesis that the developmental neurotoxicity of malathion and chlorpyrifos in guinea pigs - the best non-primate model of human OP intoxication - can be counteracted by galantamine and is largely ..
  19. Novel dominant-negative HSV-2 recombinant viral vaccines
    Feng Yao; Fiscal Year: 2011
    ..HSV-1-immunized animals, and leads to full or close to full protection against HSV-1 infection in mice and guinea pigs. Considering these favorable safety and immunological profiles of CJ9-gD and aiming to maximize levels of gD2 ..
  20. Intrauterine hypoxia induces cytokine gene expression in fetal cardiac ventricles
    LASHAUNA C EVANS; Fiscal Year: 2010
    ..We will expose pregnant guinea pigs to either normoxia (room air) or chronic hypoxia (10...
  21. Microbial Invasion of the Intestine at the Cell Extrusion Zone of the Villus Tip
    Manuel R Amieva; Fiscal Year: 2012
    ..We propose to establish an oral model of Listeria gastrointestinal infection in Guinea pigs to test this model by characterizing the sites and kinetics of intestinal invasion and colonization...
  22. Using Electrochemical Methods to Probe Neuronal Signaling in the GI Tract
    Greg M Swain; Fiscal Year: 2010
    ..in vitro in the myenteric and submucosal plexuses of the small intestine (ileum and duodenum) and colon of guinea pigs and a new SERT-KO rat animal model...
  23. Inhibition of Intestinal Na/Phosphate Cotransporter in Renal Failure and Hyperten
    BRIAN EDWARD PEERCE; Fiscal Year: 2012
    ..The goal of this proposal is to examine the toxicity and pharmacokinetics of 2FP in rats and guinea pigs. The specific aims are: 1. Determine genetic, mammalian cell, cardiac, and liver toxicity of 2FP 2...
  24. Targeted genome modification of guinea pig and sheep using engineered zinc finger
    Hilda Holcombe; Fiscal Year: 2011
    ..species, one rodent and one non-rodent, to demonstrate proof of concept and to generate genetically modified guinea pigs and sheep that are valuable models for human diseases...
  25. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    Edson X Albuquerque; Fiscal Year: 2010
    ..without the muscarinic antagonist atropine can counteract the immediate and delayed toxicity of nerve agents in guinea pigs of both sexes at different ages...
  26. Antibody immunotherapeutics for biodefense against Lassa virus
    Robert F Garry; Fiscal Year: 2013
    ..of lead candidate human monoclonal antibodies (huMAbs) that neutralize LASV infectivity and protect guinea pigs against fatal disease induced by LASV...
  27. Viral Immunomodulation and Rational CMV Vaccine Design
    Mark R Schleiss; Fiscal Year: 2013
    ..These studies use an animal model in guinea pigs to generate this new knowledge...
  28. Cell-Cell Interactions in Thrombosis -Request for Extension of Merit Award
    AARON JACOB MARCUS; Fiscal Year: 2013
    ..of norepinephrine release by NTPDases from cardiac sympathetic nerve endings (cSNE) and isolated hearts from guinea pigs, wild type and CD39 null mice...
  29. TRANSMISSION OF OSELTAMIVIR-RESISTANT INFLUENZA A H1N1 VIRUSES IN GUINEA PIGS
    Nicole M Bouvier; Fiscal Year: 2012
    ....
  30. M. tuberculosis genes required for pulmonary survival revealed by TraCS
    MARY HONDALUS; Fiscal Year: 2013
    ..This work employs a whole genome screen of an Mtb transposon mutant library administered via aerosol to guinea pigs. The guinea pig host reproduces many aspects of human tuberculosis including the necrotic, hypoxic granuloma ..
  31. ACUTE AIRWAY EFFECTS OF TLR7 AND TLR8 STIMULATION IN HEALTH AND DISEASE
    David B Jacoby; Fiscal Year: 2013
    ..We have demonstrated this effect in guinea pigs and mice, and in human airway tissues...
  32. Oral prodrug of a novel antiviral that blocks neuronal reactivation of HSV
    George E Wright; Fiscal Year: 2012
    ..determine the oral bioavailability of mCF3PG in rabbits and guinea pigs after oral treatment with Sacrovir;and 4) test, through collaborators, the efficacy of oral Sacrovir in rabbit ..
  33. Broadly Specific Needle-Free Vaccines against Emerging and Biothreat Viruses
    Alexander Bukreyev; Fiscal Year: 2013
    ..Our previous data demonstrate that mucosal respiratory tract immunization of guinea pigs and non-human primates (NHP) with vectors based on attenuated respiratory paramyxoviruses expressing EBOV GP ..
  34. Cholinergic inputs to excitatory and inhibitory midbrain auditory circuits
    JEFFREY GARRETT MELLOTT; Fiscal Year: 2013
    ..The study will be conducted in guinea pigs, a well-researched model for many aspects of auditory function...
  35. Mycobacterium Tuberculosis Lipoarabinomannan In Vivo
    Libin Shi; Fiscal Year: 2013
    ..exploit our unique ability to extract LAM from lung, granulomas, liver and kidneys from experimentally infected guinea pigs with different clinical strains, and to define the nonreducing end exhaustively focusing on the terminal ..
  36. Prevention of oxidative stress decreases persistence of drug tolerant M. Tubercu
    Randall J Basaraba; Fiscal Year: 2010
    ..Central to our proposal is the use of experimental Mtb infections in guinea pigs which develop primary lesion necrosis similar to humans with naturally occurring tuberculosis...
  37. Gated Carbon Nanotube Membrane Transdermal Drug Delivery
    BRUCE JACKSON HINDS; Fiscal Year: 2013
    ..Specific Aim 4: to characterize the pharmacokinetics of the drugs in hairless guinea pigs and Yucatan miniature pigs in order to evaluate the in vivo success of constant rate and gated delivery.
  38. RNA Interference for the Treatment of Ebola and Marburg Hemorrhagic Fever
    Ian MacLachlan; Fiscal Year: 2013
    ..3) Determine the efficacy of non-immunostimulatory siRNAs against Ebola and Marburg viruses in guinea pigs. Promising modified siRNA candidates that demonstrate significant inhibition of filoviral replication in vitro ..
  39. Endogenous surfactant therapy for the developing lung
    Bela Suki; Fiscal Year: 2013
    ..Previously, we found that in normal guinea pigs, VV increased surfactant concentration at the air-liquid interface due to increased surfactant release that we ..
  40. Early Detection and Quantification of OA
    Karen A Hasty; Fiscal Year: 2013
    ..of the medial meniscus (DMM) in mice, and two models of spontaneous osteoarthritis with Dunkin-Hartley guinea pigs and Str/Ort mice that share many features of human OA...
  41. Anatomical analysis of cortical projections to the auditory midbrain
    KYLE TOKUICHI NAKAMOTO; Fiscal Year: 2012
    ..The study will be conducted in guinea pigs, a well-researched model for many aspects of auditory function...
  42. VZV in the enteric nervous system: pathogenesis and consequences
    Michael D Gershon; Fiscal Year: 2013
    ..on conditions, VZV recapitulates latent, lytic, and reactivating infection in enteric neurons isolated from guinea pigs or mice and, when introduced to the bowel, VZV establishes latency in the guinea pig ENS in situ...
  43. Electrophysiological mapping of corticocollicular projections involved with tonot
    HUBERT HYUNGIL LIM; Fiscal Year: 2013
    ..Using ketamine-anesthetized guinea pigs, the proposed studies will investigate how electrical stimulation of different frequency and isofrequency ..
  44. Genital Herpes Vaccine Discovery
    Gary Fujii; Fiscal Year: 2010
    ..The L-HSV2gD1-306-HD vaccine will undergo further testing by immunizing male and female guinea pigs with increasing antigen doses at the optimal dosing schedule and route of administration determined from the ..
  45. CTRIP: MMP1-PAR1-based Interventions in Arterial Thrombosis
    Athan Kuliopulos; Fiscal Year: 2010
    ..the first stage of this CTRIP program, IND-enabling studies will be conducted to assess efficacy of PZ-128 in guinea pigs and non-human primates, and safety and toxicology in two other species with GMP material under GLP conditions...
  46. Renovations of the Animal Care Facility
    AWADH AMIR BINHAZIM; Fiscal Year: 2010
    ..Currently the ACF houses mice, rats, rabbits, guinea pigs, and swine...
  47. A Lassa Vaccine in primates with AIDS
    Maria Salvato; Fiscal Year: 2009
    ..It is an attenuated, infectious vaccine that protects guinea pigs from lethal challenge with Lassa fever virus...
  48. Ebola virus VP24_a novel inhibitor of interferon and oxidative stress signaling
    Christopher F Basler; Fiscal Year: 2013
    ..VP35 as a virulence factor, a VP35 mutant EBOV defective for suppression of IFN??? responses was avirulent in guinea pigs. We also demonstrated that that the EBOV VP24 protein inhibits IFN-induced Jak-STAT signaling by preventing the ..
  49. Microscopy in the cochlea
    Mark J Schnitzer; Fiscal Year: 2011
    ..non-destructive, high-resolution imaging of cochlear blood flow and microanatomy in the cochleae of living guinea pigs. To assess the effects of microendoscopy on auditory function and cochlear microarchitecture, hearing ..
  50. Evaluation of CPAF Mediated Anti-Chlamydial Immunity in the Guinea Pig
    BERNARD PRAGASH ARULANANDAM; Fiscal Year: 2012
    ..chlamydial infection in the mouse model, and (2) that the pathogenesis and immunity to chlamydial infection in guinea pigs has been shown to be remarkably similar to chlamydial genital infection in humans, we hypothesize that "..
  51. Targeted genome modification of guinea pig and sheep using engineered zinc finger
    Hilda Holcombe; Fiscal Year: 2012
    ..species, one rodent and one non-rodent, to demonstrate proof of concept and to generate genetically modified guinea pigs and sheep that are valuable models for human diseases...
  52. Bronchodilator Effects of Toll-Like Receptor-7 Agonists.
    David B Jacoby; Fiscal Year: 2011
    ..TLR7 dependent bronchodilation in guinea pigs and in human airways is mediated by production of nitric oxide...
  53. Cross-talk between Leptin and Estrogen Signaling in Hypothalamic Arcuate Neurons
    Oline K Ronnekleiv; Fiscal Year: 2013
    ..1) To characterize the leptin signaling pathway in arcuate kisspeptin neurons in ovariectomized female guinea pigs. (2) To characterize the effects of E2 on arcuate kisspeptin neurons during positive feedback versus negative ..
  54. Microneedle-enhanced codrug delivery for smoking cessation and appetite suppressi
    Audra L Stinchcomb; Fiscal Year: 2013
    ..in skin in vitro with microneedle use, and 3 - to characterize the pharmacokinetics of the drugs in guinea pigs in vivo with microneedle use...
  55. Molecular determinants of virulent arenavirus infection in hosts
    Yuying Liang; Fiscal Year: 2013
    ..developed the infectious clones for two closely related PICV strains that show opposing disease outcomes in guinea pigs. In addition, we have developed safe and convenient systems to characterize arenavirus envelope glycoprotein (..
  56. A novel live intranasal TB vaccine
    Frederick D Quinn; Fiscal Year: 2013
    ..studies demonstrated a lack of toxicity or pathogenicity in the nasal passages and lungs of mice and guinea pigs intranasally vaccinated and boosted with TBVac85 over subsequent weeks...
  57. Prevention of Hippocampal Neurodegeneration due to Age and Apnea
    Michael H Chase; Fiscal Year: 2013
    ..of the hippocampus will be combined with pharmacological and morphological studies in aged and adult (control) guinea pigs. The effects of the administration of a putative neuroprotective agent, zopiclone, on electrophysiological, ..
  58. Blocking immune evasion as a novel immunotherapy for recurrent HSV-2 infection
    HARVEY MICHAEL FRIEDMAN; Fiscal Year: 2013
    ..antigen vaccines for their ability to reduce the frequency and severity of recurrent genital infection in guinea pigs. We will determine whether immunotherapy reduces the infiltration into genital tissues of CD4+ T-cells that are ..
  59. Enhance Facilities for Infectious Disease Imaging
    RALPH E SMITH; Fiscal Year: 2010
    ..requested include Techiplast animal caging and transfer racks for mice, Thoren caging and transfer racks for guinea pigs, biological safety cabinets designed and equipped for animal cage changing and animal manipulation, and ..
  60. Protection Against Inhalation Anthrax with Inactivated Spores
    Donald G Guiney; Fiscal Year: 2012
    ..mice;Milestone 5: Determine the efficacy of the most active vaccine/adjuvant combinations in protecting guinea pigs against fully virulent anthrax infection;Milestone 6: Determine the efficacy of the optimal vaccine/adjuvant ..
  61. Broad Spectrum Treatment of Hemmorrhagic Arenaviruses
    Philip E Thorpe; Fiscal Year: 2010
    ..Bavituximab cured guinea pigs lethally infected with Pichinde virus (a model of Lassa fever)...
  62. NALTREXONE PRODRUGS FOR TRANSDERMAL DELIVERY
    Audra L Stinchcomb; Fiscal Year: 2010
    ..skin in vitro with and without microneedle use, and (4) to characterize the pharmacokinetics of the drugs in guinea pigs in vivo with and without microneedle use...
  63. MODULATORY ROLE OF GABA AND 5HT RECEPTORS IN MIGRAINE
    F Cutrer; Fiscal Year: 1999
    ..reduce trigeminal stimulation evoked plasma protein extravasation within dura mater of experimental rats and guinea pigs, as well as decrease c-fos expression within trigeminal nucleus caudalis (TNC) in guinea pigs following ..
  64. IMMUNOREGULATION OF GUT EPITHELIUM TO ESCAPE PARASITISM
    GILBERT CASTRO; Fiscal Year: 1991
    ..through an immunological reaction, are important in effecting the rapid rejection of L1 larvae in rats and guinea pigs undergoing a challenge infection...
  65. Can L-carnitine prevent drug-induced hearing loss?
    Gilda Kalinec; Fiscal Year: 2004
    ..mitochondrial function, prevented perinatal cisplatin-induced sensorineural hearing loss and cochlear damage in guinea pigs. We hypothesize that LCAR, a safe agent in humans, can decrease drug-induced ototoxicity in the guinea pig ..
  66. MOP/LAS chimeric vaccine against Lassa fever
    Igor Lukashevich; Fiscal Year: 2007
    ..to the well-studied model of arenavirus pathogenesis in the mouse, the virulence of Lassa fever in man, guinea pigs and non-human primates is directly related to viremia, and less related to immune-mediated pathology...
  67. Effect of Pertussis Toxin on Cough in Guinea Pig
    NICHOLAS CARBONETTI; Fiscal Year: 2005
    ..b>Guinea pigs represent an attractive model for mechanistic studies on cough, because many aspects of their cough ..
  68. An Inhalation Model of Q Fever in Guinea Pigs
    Kasi Russell; Fiscal Year: 2005
    ..Animal models being used to study this disease include mice and guinea pigs infected through intraperitoneal inoculation...
  69. Vaccination Against Ixodes scapularis Tick Bites
    Raymond Koski; Fiscal Year: 2001
    ..scapularis vaccine to block tick attachment and tick-mediated disease transmission. . Rabbits or guinea pigs infested with I...
  70. Vaccination Against Ixodes scapularis Tick Bites
    Michel Ledizet; Fiscal Year: 2003
    ..scapiilaris vaccine to block tick attachment and tick-mediated disease transmission. Rabbits or guinea pigs infested with I...
  71. Mopeia/Lassa Virus Reassortants as Lassa Fever Vaccines
    Igor Lukashevich; Fiscal Year: 2002
    ..to the well-studied model of arenavirus pathogenesis in the mouse, the virulence of Lassa fever in man, guinea pigs and non-human primates is directly related to viremia, and less related to immune-mediated pathology...
  72. MECHANISMS OF AIRWAY RESPONSES TO ORGANIC DUSTS
    Terry Gordon; Fiscal Year: 1993
    ..released in response to endotoxin, to determine whether they mimic the airway obstruction and edema observed in guinea pigs exposed to inhaled endotoxin...