rodentia

Summary

Summary: A mammalian order which consists of 29 families and many genera.

Top Publications

  1. pmc A global perspective on hantavirus ecology, epidemiology, and disease
    Colleen B Jonsson
    Department of Microbiology and Immunology, University of Louisville, 950 N Hurstbourne Parkway, Louisville, KY 40222, USA
    Clin Microbiol Rev 23:412-41. 2010
  2. pmc Rodent phylogeny revised: analysis of six nuclear genes from all major rodent clades
    Shani Blanga-Kanfi
    Department of Zoology, George S, Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    BMC Evol Biol 9:71. 2009
  3. doi Rodent-borne diseases and their risks for public health
    Bastiaan G Meerburg
    Wageningen University and Research Centre, Plant Research International, Wageningen, The Netherlands
    Crit Rev Microbiol 35:221-70. 2009
  4. pmc A glimpse on the pattern of rodent diversification: a phylogenetic approach
    Pierre Henri Fabre
    Center for Macroecology, Evolution and Climate CMEC, Department of Biology, Zoological Museum, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    BMC Evol Biol 12:88. 2012
  5. pmc Ancient DNA reveals Holocene loss of genetic diversity in a South American rodent
    Yvonne L Chan
    Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305 5020, USA
    Biol Lett 1:423-6. 2005
  6. doi Rodent evolution: back to the root
    Gennady Churakov
    Institute of Experimental Pathology ZMBE, University of Munster, Munster, Germany
    Mol Biol Evol 27:1315-26. 2010
  7. ncbi Rodent phylogeny and a timescale for the evolution of Glires: evidence from an extensive taxon sampling using three nuclear genes
    Dorothee Huchon
    Laboratoire de Paléontologie, Paléobiologie et Phylogénie CC064, Institut des Sciences de l Evolution UMR 5554 CNRS, Universite Montpellier II, Place E Bataillon, Montpellier Cedex 05, France
    Mol Biol Evol 19:1053-65. 2002
  8. ncbi Arrival and diversification of caviomorph rodents and platyrrhine primates in South America
    Celine Poux
    Laboratoire de Paléontologie, Phylogénie et Paléobiologie, CC064, Institut des Sciences de l Evolution UMR 5554 CNRS, Universite Montpellier II, Place E, Bataillon, 34 095, Montpellier Cedex 05, France
    Syst Biol 55:228-44. 2006
  9. doi Genomic scans support repetitive continental colonization events during the rapid radiation of voles (Rodentia: Microtus): the utility of AFLPs versus mitochondrial and nuclear sequence markers
    Sabine Fink
    Department of Biology, Computational and Molecular Population Genetics CMPG, Institute of Ecology and Evolution, University of Bern, Baltzerstrasse 6, CH 3012 Bern, Switzerland
    Syst Biol 59:548-72. 2010
  10. ncbi Patterns of infection with Laguna Negra virus in wild populations of Calomys laucha in the central Paraguayan chaco
    C J Yahnke
    Department of Biological Sciences, Northern Illinois University, DeKalb 60115, USA
    Am J Trop Med Hyg 65:768-76. 2001

Detail Information

Publications317 found, 100 shown here

  1. pmc A global perspective on hantavirus ecology, epidemiology, and disease
    Colleen B Jonsson
    Department of Microbiology and Immunology, University of Louisville, 950 N Hurstbourne Parkway, Louisville, KY 40222, USA
    Clin Microbiol Rev 23:412-41. 2010
    ....
  2. pmc Rodent phylogeny revised: analysis of six nuclear genes from all major rodent clades
    Shani Blanga-Kanfi
    Department of Zoology, George S, Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    BMC Evol Biol 9:71. 2009
    b>Rodentia is the most diverse order of placental mammals, with extant rodent species representing about half of all placental diversity...
  3. doi Rodent-borne diseases and their risks for public health
    Bastiaan G Meerburg
    Wageningen University and Research Centre, Plant Research International, Wageningen, The Netherlands
    Crit Rev Microbiol 35:221-70. 2009
    ..In this review article a large number of pathogens that are directly or indirectly transmitted by rodents are described. Moreover, a simplified rodent disease model is discussed...
  4. pmc A glimpse on the pattern of rodent diversification: a phylogenetic approach
    Pierre Henri Fabre
    Center for Macroecology, Evolution and Climate CMEC, Department of Biology, Zoological Museum, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    BMC Evol Biol 12:88. 2012
    ..However, despite the increase of studies addressing the diversification patterns of organisms, no synthesis has addressed the case of the most diversified mammalian clade: the Rodentia.
  5. pmc Ancient DNA reveals Holocene loss of genetic diversity in a South American rodent
    Yvonne L Chan
    Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305 5020, USA
    Biol Lett 1:423-6. 2005
    ..Our results highlight the importance of non-anthropogenic factors in loss of diversity, including reductions in smaller mammals such as rodents...
  6. doi Rodent evolution: back to the root
    Gennady Churakov
    Institute of Experimental Pathology ZMBE, University of Munster, Munster, Germany
    Mol Biol Evol 27:1315-26. 2010
    ....
  7. ncbi Rodent phylogeny and a timescale for the evolution of Glires: evidence from an extensive taxon sampling using three nuclear genes
    Dorothee Huchon
    Laboratoire de Paléontologie, Paléobiologie et Phylogénie CC064, Institut des Sciences de l Evolution UMR 5554 CNRS, Universite Montpellier II, Place E Bataillon, Montpellier Cedex 05, France
    Mol Biol Evol 19:1053-65. 2002
    b>Rodentia is the largest order of placental mammals, with approximately 2,050 species divided into 28 families. It is also one of the most controversial with respect to its monophyly, relationships between families, and divergence dates...
  8. ncbi Arrival and diversification of caviomorph rodents and platyrrhine primates in South America
    Celine Poux
    Laboratoire de Paléontologie, Phylogénie et Paléobiologie, CC064, Institut des Sciences de l Evolution UMR 5554 CNRS, Universite Montpellier II, Place E, Bataillon, 34 095, Montpellier Cedex 05, France
    Syst Biol 55:228-44. 2006
    ..By contrast, few platyrrhine fossils are known in the Oligocene, and the present-day taxa are the result of a quite recent, Early Miocene diversification...
  9. doi Genomic scans support repetitive continental colonization events during the rapid radiation of voles (Rodentia: Microtus): the utility of AFLPs versus mitochondrial and nuclear sequence markers
    Sabine Fink
    Department of Biology, Computational and Molecular Population Genetics CMPG, Institute of Ecology and Evolution, University of Bern, Baltzerstrasse 6, CH 3012 Bern, Switzerland
    Syst Biol 59:548-72. 2010
    ..More generally, this study supports the suitability of AFLPs as an alternative to sequence markers to resolve the evolutionary history of rapidly radiating taxa...
  10. ncbi Patterns of infection with Laguna Negra virus in wild populations of Calomys laucha in the central Paraguayan chaco
    C J Yahnke
    Department of Biological Sciences, Northern Illinois University, DeKalb 60115, USA
    Am J Trop Med Hyg 65:768-76. 2001
    ..laucha in the small mammal community. These data suggest that community-level dynamics, in addition to population-level dynamics, may be involved in the transmission of the virus through natural populations of vesper mice...
  11. pmc Tick parasites of rodents in Romania: host preferences, community structure and geographical distribution
    Andrei D Mihalca
    Department of Parasitology and Parasitic Diseases, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, Calea Manastur 3 5, Cluj Napoca 400372, Romania
    Parasit Vectors 5:266. 2012
    ..Micromammal-tick associations have been poorly studied in Romania, and our manuscript shows the results of a large scale study on tick infestation epidemiology in rodents from Romania...
  12. pmc Temporal dynamics and impact of climate factors on the incidence of zoonotic cutaneous leishmaniasis in central Tunisia
    Amine Toumi
    Laboratory of Medical Epidemiology, Pasteur Institute of Tunis, Tunis, Tunisia
    PLoS Negl Trop Dis 6:e1633. 2012
    ..Like other vector-borne diseases, the incidence of ZCL displayed by humans varies with environmental and climate factors. However, so far no study has addressed the temporal dynamics or the impact of climate factors on the ZCL risk...
  13. ncbi Variables that modulate the spatial distribution of Trypanosoma cruzi and Trypanosoma evansi in the Brazilian Pantanal
    H M Herrera
    Laboratório de Biologia de Tripanosomatídeos, Departamento de Protozoologia, FIOCRUZ RJ, Av Brasil 4365, CEP 21045 900, Rio de Janeiro, RJ, Brazil
    Acta Trop 102:55-62. 2007
    ..Together with the observation that small mammals diversity in FA is similar to RN area suggest that ranching activity may also not necessarily conduct to biodiversity loss or risk of Chagas disease...
  14. pmc Rodent abundance dynamics and leptospirosis carriage in an area of hyper-endemicity in New Caledonia
    Julie Perez
    Institut Pasteur de Nouvelle Caledonie, Réseau International des Instituts Pasteur, Laboratoire de Recherche en Bactériologie, Noumea, New Caledonia
    PLoS Negl Trop Dis 5:e1361. 2011
    ..A better knowledge of how rodent populations and their Leptospira prevalence respond to seasonal and meteorological fluctuations might help implement relevant control measures...
  15. pmc Babesia spp. and Anaplasma phagocytophilum in questing ticks, ticks parasitizing rodents and the parasitized rodents--analyzing the host-pathogen-vector interface in a metropolitan area
    Cornelia Silaghi
    Comparative Tropical Medicine and Parasitology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Parasit Vectors 5:191. 2012
    ..and Anaplasma phagocytophilum in restored areas in both questing and host-attached Ixodes ricinus and Dermacentor reticulatus and their small mammalian hosts...
  16. pmc Tick-borne agents in rodents, China, 2004-2006
    Lin Zhan
    Beijing Institute of Microbiology and Epidemiology, Beijing, People s Republic of China
    Emerg Infect Dis 15:1904-8. 2009
    ..These findings demonstrate that these tick-borne agents cocirculate and that a variety of rodent species may be involved in their enzootic maintenance...
  17. pmc Telomerase activity coevolves with body mass not lifespan
    Andrei Seluanov
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Aging Cell 6:45-52. 2007
    ..These results suggest that large body mass presents a greater risk of cancer than long lifespan, and large animals evolve repression of telomerase activity to mitigate that risk...
  18. doi Circadian pattern of wheel-running activity of a South American subterranean rodent (Ctenomys cf knightii)
    Veronica Sandra Valentinuzzi
    Centro de Investigacion Cientifica y de Transferencia Tecnologica CRILAR, Entre Rios y Mendoza s n, 5301, Anillaco, La Rioja, Argentina
    Chronobiol Int 26:14-27. 2009
    ..These data are the first step toward understanding the chronobiology of the largest genus of subterranean rodents...
  19. pmc Climate, deer, rodents, and acorns as determinants of variation in lyme-disease risk
    Richard S Ostfeld
    Institute of Ecosystem Studies, Millbrook, New York, USA
    PLoS Biol 4:e145. 2006
    ....
  20. pmc Finite element modelling of squirrel, guinea pig and rat skulls: using geometric morphometrics to assess sensitivity
    P G Cox
    Department of Musculoskeletal Biology, University of Liverpool, Liverpool, UK
    J Anat 219:696-709. 2011
    ....
  21. pmc Genome dynamics of Bartonella grahamii in micro-populations of woodland rodents
    Eva C Berglund
    Department of Moleculcar Evolution, Norbyvagen 18C, S 75236 Uppsala, Sweden
    BMC Genomics 11:152. 2010
    ..The sequence variability within the global B. grahamii population was recently investigated by multi locus sequence typing, but no study on the variability of putative host-cell interaction systems has been performed...
  22. ncbi Current issues and perspectives in small rodent magnetic resonance imaging using clinical MRI scanners
    Marc A Brockmann
    Department of Neuroradiology, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 61867 Mannheim, Germany
    Methods 43:79-87. 2007
    ..This review provides an overview of current concepts, limitations, and recent studies dealing with small animal imaging using clinical MR scanners...
  23. ncbi Fluctuating rodent populations and risk to humans from rodent-borne zoonoses
    S Davis
    Department of Biology, University of Antwerp, Antwerp, Belgium
    Vector Borne Zoonotic Dis 5:305-14. 2005
    ..The few longer field studies (>5 years) show a positive but delayed relationship between reservoir abundance and reservoir prevalence...
  24. doi Parasite genetic differentiation by habitat type and host species: molecular epidemiology of Schistosoma japonicum in hilly and marshland areas of Anhui Province, China
    James W Rudge
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, UK
    Mol Ecol 18:2134-47. 2009
    ..japonicum control, particularly in hilly regions where control of infection among wild rodent populations could be challenging...
  25. ncbi High-level similarity of dentitions in carnivorans and rodents
    Alistair R Evans
    Evolution and Development Unit, Institute of Biotechnology, PO Box 56 Viikinkaari 9, FIN 00014 University of Helsinki, Finland
    Nature 445:78-81. 2007
    ..This link between diet and phenotype will be useful for inferring the ecology of extinct species and illustrates the potential of fast-throughput, high-level analysis of the phenotype...
  26. ncbi Deleterious mutations and the evolution of sex
    P D Keightley
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Science 290:331-3. 2000
    ..In species with short generation times, U is predicted to be far below 1, suggesting that sex is not maintained by its capacity to purge the genome of deleterious mutations...
  27. doi Contrasting reservoirs for Schistosoma japonicum between marshland and hilly regions in Anhui, China--a two-year longitudinal parasitological survey
    Da Bing Lu
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, Norfolk Place, London W2 1PG, UK
    Parasitology 137:99-110. 2010
    ..Such results may have implications for the current human- and bovine-oriented control policy for this medically and veterinarily important disease, particularly within the hilly regions of mainland China...
  28. doi Retinal photoreceptors of two subterranean tuco-tuco species (Rodentia, Ctenomys): morphology, topography, and spectral sensitivity
    Cristian E Schleich
    Laboratorio Ecofisiología, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Argentina
    J Comp Neurol 518:4001-15. 2010
    ..Avoiding predators and selecting food during the brief aboveground excursions may have exerted pressure to retain robust cone-based vision in Ctenomys. UV tuning of the S cone pigment is shared with a number of other hystricomorphs...
  29. ncbi Modeling hantavirus reservoir species dominance in high seroprevalence areas on the Azuero Peninsula of Panama
    Gerardo Suzán
    Museum of Southwestern Biology and Department of Biology, University of New Mexico, Albuquerque, 87131 0001, USA
    Am J Trop Med Hyg 74:1103-10. 2006
    ..The model predicts highest abundances of Z. brevicauda in flat areas, where humans also dominate. These predictions have important ecological and conservation implications that associate diversity loss, topography, and human land use...
  30. ncbi PCR-based diagnosis for detection of Leishmania in skin and blood of rodents from an endemic area of cutaneous and visceral leishmaniasis in Brazil
    Fernanda S Oliveira
    Laboratório de Sistemática Bioquímica, Departamento de Bioquimica e Biologia Molecular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz FIOCRUZ, Rio de Janeiro, Brasil
    Vet Parasitol 129:219-27. 2005
    ..L.) chagasi in a naturally infected T. apereoides. The utility of filter paper as a substrate for PCR analyses and the efficacy of the procedure associated to the hybridization is emphasized...
  31. ncbi Susceptibility of spiny rats (Proechimys semispinosus) to Leishmania (Viannia) panamensis and Leishmania (Leishmania) chagasi
    B L Travi
    Centro Internacional de Entrenamiento e Investigaciones Medicas, Cali, Colombia
    Mem Inst Oswaldo Cruz 97:887-92. 2002
    ..panamensis, combined with population characteristics, e.g., abundance, exploitation of degraded habitats and high reproductive rates, could make them epidemiologically suitable reservoirs...
  32. ncbi Wild and synanthropic hosts of Leishmania (Viannia) braziliensis in the endemic cutaneous leishmaniasis locality of Amaraji, Pernambuco State, Brazil
    Sinval P Brandão-Filho
    Centro de Pesquisas Aggeu Magalhaes, FIOCRUZ, Av Moraes Rego, S N, Recife 50670 420, Pernambuco, Brazil
    Trans R Soc Trop Med Hyg 97:291-6. 2003
    ..V.) braziliensis. The isolation of zymodeme IOC/Z74 from humans reinforces our hypothesis that small, ground-loving mammals, such as rodents are the primary reservoirs of L. (V.) braziliensis...
  33. ncbi Phylogeny of muroid rodents: relationships within and among major lineages as determined by IRBP gene sequences
    Sharon A Jansa
    Bell Museum of Natural History and Department of Ecology, Evolution, and Behavior, University of Minnesota, St Paul, MN, USA
    Mol Phylogenet Evol 31:256-76. 2004
    ..A preliminary examination of molar tooth morphology on the resulting phylogeny suggests the triserial murid molar pattern as conceived by evolved at least three times during the course of muroid evolution...
  34. ncbi Jungles: a new solution to the host/parasite phylogeny reconciliation problem
    M A Charleston
    Division of Environmental and Evolutionary Biology, University of Glasgow, UK
    Math Biosci 149:191-223. 1998
    ..A simple example is given, and the pocket gopher/chewing louse system investigated by Hafner and Nadler [Hafner and Nadler, Nature 332 (1988) 258] is re-examined...
  35. doi Associations between Ixodes scapularis ticks and small mammal hosts in a newly endemic zone in southeastern Canada: implications for Borrelia burgdorferi transmission
    C Bouchard
    Groupe de Recherche en Epidémiologie des Zoonoses et Santé Publique, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec, Canada
    Ticks Tick Borne Dis 2:183-90. 2011
    ..However, our study also suggested that habitats containing a diverse host structure may dilute transmission cycles by partitioning of nymphal and larval ticks on different host species...
  36. pmc First detection of Leishmania killicki (Kinetoplastida, Trypanosomatidae) in Ctenodactylus gundi (Rodentia, Ctenodactylidae), a possible reservoir of human cutaneous leishmaniasis in Tunisia
    Kaouther Jaouadi
    Laboratoire de Parasitologie Mycologie 99UR 08 05, Departement de Biologie Clinique, Faculté de Pharmacie de Monastir, Tunisia
    Parasit Vectors 4:159. 2011
    ..Nevertheless, neither vector nor reservoirs of this parasite are known. The identification of the vector and the animal reservoir host of L. killicki is critical for the establishment of an efficient control strategy...
  37. ncbi Poor housing quality increases risk of rodent infestation and Lassa fever in refugee camps of Sierra Leone
    Phillip Cullison Bonner
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Trop Med Hyg 77:169-75. 2007
    ..These findings suggest that risk of Lassa fever in refugee camps depends on individual housing quality and the hygiene of the immediate surrounding environment...
  38. doi First complete genomic characterization of two tick-borne encephalitis virus isolates obtained from wild rodents in South Korea
    Seok Min Yun
    National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongwon Gun, South Korea
    Virus Genes 42:307-16. 2011
    ..The results provide insight into the genetics of TBEV strains to understand the molecular epidemiology, genetic diversity, and evolution of TBEV...
  39. ncbi Local molecular clocks in three nuclear genes: divergence times for rodents and other mammals and incompatibility among fossil calibrations
    Emmanuel J P Douzery
    Laboratoire de Paléontologie, Paléobiologie et Phylogénie CC064, Institut des Sciences de l Evolution UMR 5554 CNRS, Universite Montpellier II, Place E Bataillon, 34 095 Montpellier Cedex 05, France
    J Mol Evol 57:S201-13. 2003
    ..Global clocks, local clocks, and quartet dating analyses suggested a Late Cretaceous origin of the crown placental clades followed by a Tertiary radiation of some placental orders like rodents...
  40. pmc Suprafamilial relationships among Rodentia and the phylogenetic effect of removing fast-evolving nucleotides in mitochondrial, exon and intron fragments
    Claudine Montgelard
    Institut des Sciences de l Evolution de Montpellier UMR 5554, Universite de Montpellier II, Place Eugene Bataillon, 34095 Montpellier Cedex, France
    BMC Evol Biol 8:321. 2008
    ....
  41. pmc Using geographic information system-based ecologic niche models to forecast the risk of hantavirus infection in Shandong Province, China
    Lan Wei
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People s Republic of China
    Am J Trop Med Hyg 84:497-503. 2011
    ..These findings have the applications for targeting control and prevention efforts...
  42. ncbi Hantavirus infections in Europe
    Olli Vapalahti
    Division of Microbiology and Epidemiology, Faculty of Veterinary Medicine, University of Helsinki and HUCH Laboratory Diagnostics, Helsinki University Central Hospital, Finland
    Lancet Infect Dis 3:653-61. 2003
    ..Typing of a specific hantavirus infection requires neutralisation antibody assays or reverse transcriptase PCR and sequencing...
  43. pmc Rodent and flea abundance fail to predict a plague epizootic in black-tailed prairie dogs
    Robert Jory Brinkerhoff
    Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, Colorado 80309 0334, USA
    Vector Borne Zoonotic Dis 10:47-52. 2010
    ....
  44. pmc Spatial and temporal dynamics of lymphocytic choriomeningitis virus in wild rodents, northern Italy
    Valentina Tagliapietra
    Edmund Mach Foundation Istituto Agrario di San Michele all Adige, San Michele all Adige, Italy
    Emerg Infect Dis 15:1019-25. 2009
    ..Isolation and genetic characterization of this virus will be the crucial next steps for a better understanding of its ecology...
  45. doi Bartonella spp. infection in rodents from different habitats in the Mazury Lake District, Northeast Poland
    Renata Welc-Faleciak
    Department of Parasitology, Institute of Zoology, University of Warsaw, Warsaw, Poland
    Vector Borne Zoonotic Dis 8:467-74. 2008
    ..glareolus were identical to B. grahamii, species associated with human illness. These results have important public health implication, notably in relation to the risk of infection in humans following exposure to rodent bartonellae...
  46. ncbi Molecular evidence of an African Phiomorpha-South American Caviomorpha clade and support for Hystricognathi based on the complete mitochondrial genome of the cane rat (Thryonomys swinderianus)
    S K Mouchaty
    Division of Evolutionary Molecular Systematics, Institute of Genetics, University of Lund, Solvegatan 29, S 223 62 Lund, Sweden
    Mol Phylogenet Evol 18:127-35. 2001
    The complete mitochondrial genome of an African cane rat, Thryonomys swinderianus (Rodentia, Hystricognathi), was included in a phylogenetic analysis along with 4 rodents, 14 additional eutherians, and 3 noneutherian outgroups...
  47. pmc Hantavirus pulmonary syndrome, central plateau, southeastern, and southern Brazil
    Luiz T M Figueiredo
    University of Sao Paulo School of Medicine, Ribeirao Preto, Brazil
    Emerg Infect Dis 15:561-7. 2009
    ..The case-fatality rate of HPS was higher in the area with Araraquara virus. This virus, which may be the most virulent hantavirus in Brazil, was associated with areas that have had greater anthropogenic changes...
  48. doi Evolutional and geographical relationships of Bartonella grahamii isolates from wild rodents by multi-locus sequencing analysis
    Kai Inoue
    Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan
    Microb Ecol 57:534-41. 2009
    ..The phylogenetic analysis and host specificity of B. grahamii raise the possibility that B. grahamii strains originating in the North American continent were distributed to European countries by adapting to various rodent hosts...
  49. pmc Masticatory muscle architecture in the Laotian rock rat Laonastes aenigmamus (Mammalia, Rodentia): new insights into the evolution of hystricognathy
    Lionel Hautier
    Laboratoire de Paléontologie, Institut des Sciences de l Evolution de Montpellier, UMR CNRS 5554, CC 064, Université de Montpellier 2, 34095 Montpellier Cedex, France
    J Anat 215:401-10. 2009
    ..These results bring new insights into the evolution of hystricognathy and have profound implications for the interpretation of the fossil record of early hystricognath rodents...
  50. doi Utilisation of rodent species by larvae and nymphs of hard ticks (Ixodidae) in two habitats in NE Poland
    Anna Paziewska
    University of Warsaw, Warsaw, Poland
    Exp Appl Acarol 50:79-91. 2010
    ..The impact of habitat change (in this case successional change following field abandonment) on tick densities is emphasised, and the role of Apodemus as an epidemiological bridge, linking woodland and field habitats, is highlighted...
  51. ncbi Calodium hepaticum (syn. Capillaria hepatica) in captive rodents in a zoological garden
    S P Redrobe
    Bristol Zoo Gardens, Guthrie Road, Clifton, Bristol BS8 3HA, UK
    J Comp Pathol 133:73-6. 2005
    ..As C. hepaticum is potentially zoonotic, members of staff in zoos should be careful to avoid soil-to-mouth contact, particularly in prairie dog enclosures...
  52. ncbi Associations between leptospiral infection and seropositivity in rodents and environmental characteristics in Argentina
    N B Vanasco
    Instituto Nacional de Enfermedades, Respiratorias E Coni, Administracion Nacional de Laboratorios e Institutos de Salud, Blas Parera 8260, 3000 Santa Fe, Argentina
    Prev Vet Med 60:227-35. 2003
    ..Adults and subadults had higher seroprevalences than juvenile rodents. Oligoryzomys flavescens had higher seroprevalence than Akodon azarae, Mus musculus, Rattus rattus and Rattus norvegicus...
  53. doi Effect of deer density on tick infestation of rodents and the hazard of tick-borne encephalitis. II: population and infection models
    L Bolzoni
    Department of Biodiversity and Molecular Ecology, Research and Innovation Centre Fondazione Edmund Mach, San Michele all Adige, Trento, Italy
    Int J Parasitol 42:373-81. 2012
    ..As a consequence, using simply the number of ticks per rodent as a predictor of TBE transmission potential could be misleading if competent hosts share habitats with incompetent hosts...
  54. pmc Differential transmission of the genospecies of Borrelia burgdorferi sensu lato by game birds and small rodents in England
    K Kurtenbach
    Department of Zoology, University of Oxford, United Kingdom
    Appl Environ Microbiol 64:1169-74. 1998
    ..Wildlife management may have an influence on the relative risk of different clinical forms of Lyme borreliosis...
  55. ncbi Hantavirus pulmonary syndrome in northwestern Argentina: circulation of Laguna Negra virus associated with Calomys callosus
    Silvana Levis
    Instituto Nacional de Enfermedades Virales Humanas Dr Julio I Maiztegui, Monteagudo 2510, 2700 Pergamino, Buenos Aires, Argentina
    Am J Trop Med Hyg 71:658-63. 2004
    ..8% at the nucleotide level and 2.9% at the protein level relative to the Paraguayan LN virus. The other two hantavirus lineages identified were the previously known Bermejo and Oran viruses...
  56. ncbi Population dynamics of two sympatric rodents in a variable environment: rainfall, resource availability, and predation
    M Andrea Previtali
    Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115, USA
    Ecology 90:1996-2006. 2009
    ..Our results contribute to a growing number of examples of dynamics governed by the combined effect of density dependence and climatic forcing. They also reveal strong bottom-up regulation that may be common in other arid environments...
  57. ncbi Association of Borrelia afzelii with rodents in Europe
    K Hanincová
    Department of Infectious Disease Epidemiology, Imperial College of Science, Technology and Medicine, Norfolk Place, London W2 1PG, UK
    Parasitology 126:11-20. 2003
    ..afzelii is specifically maintained by European rodents, validating the concept of host-association of B. burgdorferi s.l...
  58. ncbi Tooth eruption: theories and facts
    S C Marks
    Department of Cell Biology, University of Massachusetts Medical School, Worcester 01655, USA
    Anat Rec 245:374-93. 1996
    ..We conclude with basic principles of tooth eruption--that is, the type of signals generated by the dental follicle proper, the conditions under which teeth are moved and the clinical understanding to be derived from this knowledge...
  59. ncbi Stem Lagomorpha and the antiquity of Glires
    Robert J Asher
    Museum für Naturkunde, Humboldt Universitat, Invalidenstrasse 43, 10115 Berlin, Germany
    Science 307:1091-4. 2005
    ..Our results support the hypothesis that rodents and lagomorphs radiated during the Cenozoic and diverged from other placental mammals close to the Cretaceous-Tertiary boundary...
  60. doi Evolution in a multi-host parasite: chronobiological circadian rhythm and population genetics of Schistosoma japonicum cercariae indicates contrasting definitive host reservoirs by habitat
    Da Bing Lu
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, Norfolk Place, London W2 1PG, UK
    Int J Parasitol 39:1581-8. 2009
    ..Such parasite diversity could, in turn, provide an explanation for the different infection scenarios observed between the two regions, and hence have important applied implications in terms of targeted control of key reservoirs...
  61. doi Oxytocin and vasopressin receptor distributions in a solitary and a social species of tuco-tuco (Ctenomys haigi and Ctenomys sociabilis)
    Annaliese K Beery
    Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA
    J Comp Neurol 507:1847-59. 2008
    ..sociabilis. Future studies will expand on these analyses to explore interspecific differences in ctenomyid receptor binding patterns in a phylogenetic context...
  62. doi Codivergence in heteromyid rodents (Rodentia: heteromyidae) and their sucking lice of the genus Fahrenholzia (Phthiraptera: anoplura)
    Jessica E Light
    Department of Biological Sciences and Museum of Natural Science, Louisiana State University, Baton Rouge, LA 70803, USA
    Syst Biol 57:449-65. 2008
    ..of branch lengths are used in this study to understand the host-parasite association between heteromyid rodents (Rodentia: Heteromyidae) and their sucking lice of the genus Fahrenholzia (Phthiraptera: Anoplura)...
  63. doi Coevolutionary relationship between helminth diversity and MHC class II polymorphism in rodents
    J Goüy de Bellocq
    Research Institute of Wildlife Ecology, University of Veterinary Medicine, Vienna, Austria
    J Evol Biol 21:1144-50. 2008
    ..Our results are consistent with the idea that parasites sharing a long-term coevolutionary history with their hosts are the agents of selection explaining MHC polymorphism...
  64. pmc Scatter-hoarding rodents prefer slightly astringent food
    Bo Wang
    Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Yunnan, China
    PLoS ONE 6:e26424. 2011
    ..Instead, the two partners appear to have reached an evolutionary point where both parties receive adequate benefits, with the year-to-year outcome being dependent on a wide range of factors beyond the control of either partner...
  65. pmc Novel genospecies of Borrelia burgdorferi sensu lato from rodents and ticks in southwestern China
    Chen Yi Chu
    Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, People s Republic of China
    J Clin Microbiol 46:3130-3. 2008
    ..burgdorferi sensu lato rather than B. valaisiana. The finding explained the differences in transmission cycle and phenotype between B. valaisiana strains from Europe and B. valaisiana-related strains from eastern Asia...
  66. doi Phylogenetic characterization of hantaviruses from wild rodents and hantavirus pulmonary syndrome cases in the state of Parana (southern Brazil)
    Sonia Mara Raboni
    Instituto Carlos Chagas, ICC Fiocruz PR, Brazil
    J Gen Virol 90:2166-71. 2009
    ....
  67. ncbi Whole parasite blood stage malaria vaccines: a convergence of evidence
    James S McCarthy
    Queensland Institute for Medical Research and School of Medicine, University of Queensland, Queensland, Australia
    Hum Vaccin 6:114-23. 2010
    ..Finally, the prospect for and impediments to the development whole blood stage parasites are reviewed...
  68. ncbi Rates of conservative and radical nonsynonymous nucleotide substitutions in mammalian nuclear genes
    J Zhang
    Institute of Molecular Evolutionary Genetics, Pennsylvania State University, University Park 16802, USA
    J Mol Evol 50:56-68. 2000
    ..5) Transversions induce more dramatic genetic alternations than transitions in that transversions produce more amino acid altering changes and among which, more radical changes...
  69. doi Zoonotic aspects of arenavirus infections
    R N Charrel
    Unite des Virus Emergents, UMR190 Emergence des pathologies virales Université de Méditerranée, Institut de Recherche pour Développement, Faculte de Medecine, Marseille, France
    Vet Microbiol 140:213-20. 2010
    ..The approach based on consensus degenerate primers has shown efficient for both detection of known arenaviruses, and discovery of new arenaviruses...
  70. pmc Active and passive surveillance and phylogenetic analysis of Borrelia burgdorferi elucidate the process of Lyme disease risk emergence in Canada
    Nicholas H Ogden
    Centre for Food borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Saint Hyacinthe, Quebec, Canada
    Environ Health Perspect 118:909-14. 2010
    ..Northward expansion of the tick Ixodes scapularis is driving Lyme disease (LD) emergence in Canada. Information on mechanisms involved is needed to enhance surveillance and identify where LD risk is emerging...
  71. doi Flea diversity and infestation prevalence on rodents in a plague-endemic region of Uganda
    Gerald Amatre
    Uganda Virus Research Institute, Entebbe, Uganda
    Am J Trop Med Hyg 81:718-24. 2009
    ..Future studies are needed to determine whether flea abundance or species composition changes during epizootics when humans are most at risk of exposure...
  72. doi Hantavirus evolution in relation to its rodent and insectivore hosts: no evidence for codivergence
    Cadhla Ramsden
    Center for Infectious Disease Dynamics, Department of Biology, Mueller Laboratory, The Pennsylvania State University, USA
    Mol Biol Evol 26:143-53. 2009
    ..Based on the presence of clade-defining amino acids in all genomic segments, we propose that the patterns of amino acid replacement in these viruses are also compatible with a history of host-specific adaptation...
  73. ncbi Phylogenetic analysis of the Arenaviridae: patterns of virus evolution and evidence for cospeciation between arenaviruses and their rodent hosts
    M D Bowen
    Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Mol Phylogenet Evol 8:301-16. 1997
    ..The pathogenic arenaviruses do not appear to be monophyletic, suggesting that the pathogenic phenotype has arisen in multiple independent events during virus evolution...
  74. pmc Using giant African pouched rats to detect tuberculosis in human sputum samples: 2009 findings
    Alan Poling
    Anti Persoonsmijnen Ontmijnende Product Ontwikkeling, Morogoro, Tanzania
    Am J Trop Med Hyg 83:1308-10. 2010
    ..These data suggest that the rats may be useful for TB detection in developing countries, although further research is needed...
  75. ncbi Laonastes and the "Lazarus effect" in recent mammals
    Mary R Dawson
    Section of Vertebrate Paleontology, Carnegie Museum of Natural History, 4400 Forbes Avenue, Pittsburgh, PA 15213, USA
    Science 311:1456-8. 2006
    ....
  76. pmc Fossil and molecular evidence constrain scenarios for the early evolutionary and biogeographic history of hystricognathous rodents
    Hesham M Sallam
    Department of Earth Sciences, University of Oxford, Parks Road, Oxford, United Kingdom
    Proc Natl Acad Sci U S A 106:16722-7. 2009
    ..These results are remarkably congruent with our phylogenetic results and the fossil record of hystricognathous rodent evolution in Afro-Arabia and South America...
  77. ncbi Emergence and persistence of hantaviruses
    S L Klein
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Curr Top Microbiol Immunol 315:217-52. 2007
    ..In addition, we summarize all these complexities and provide suggestions for future research directions...
  78. ncbi Evolution of South American spiny rats (Rodentia, Echimyidae): the star-phylogeny hypothesis revisited
    Yuri L R Leite
    Museum of Vertebrate Zoology, 3101 Valley Life Science Building, University of California, Berkeley 94720 3160, USA
    Mol Phylogenet Evol 25:455-64. 2002
    ..We suggest that most of the cladogenesis leading to the extant echimyid genera probably occurred during the Late Miocene, about eight million years ago...
  79. ncbi Flea, rodent, and plague ecology at Chuchupate Campground, Ventura County, California
    Richard M Davis
    Vector Borne Disease Section, California Department of Health Services, Ventura 93003, USA
    J Vector Ecol 27:107-27. 2002
    ..Host preference, diversity, and seasonality of fleas are discussed, as well as the pivotal role of woodrat houses and nests as foci for hosts, fleas, and plague...
  80. ncbi Evolutionary transformations of chorioallantoic placental characters in rodentia with special reference to hystricognath species
    Andrea Mess
    Institut für Systematische Zoologie, Museum für Naturkunde, Humboldt Universitat Berlin, Invalidenstrasse 43, 10115 Berlin, Germany
    J Exp Zool A Comp Exp Biol 299:78-98. 2003
    The aim of this paper is to reconstruct the evolution of chorioallantoic placental characters in Rodentia. The analysis is based on pre-existing hypotheses of rodent relationships and the tracing of character evolution...
  81. ncbi B1 SINEs in different rodent families
    Natalia A Veniaminova
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Street, Moscow 119991, Russia
    Genomics 89:678-86. 2007
    ..Different B1 subfamilies predominate in different rodent families. The analysis of B1 variants allowed us to propose possible pathways for the evolution of this SINE in the context of rodent evolution...
  82. ncbi Redescription of Trichuris pampeana (Nematoda: Trichuridae) from the South American subterranean rodent Ctenomys talarum Thomas, 1898 (Rodentia: Octodontidae)
    M Alejandra Rossin
    Laboratorio de Ecofisiologia, Departamento de Biologia, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Funes 3250, Casilla de Correo 1245, 7600 Mar del Plata, Argentina
    J Parasitol 91:127-30. 2005
    ..Nematoda: Trichuridae) is redescribed from voucher specimens from the type host Ctenomys azarae Thomas, 1903 (Rodentia: Octodontidae) and from parasites collected from 2 populations of the subterranean rodent C...
  83. ncbi A new species of Vexillata (Nematoda: Trichostrongylina: Ornithostrongylidae) parasite of Heteromys desmarestianus (Rodentia: Heteromyidae) from Costa Rica
    Jorge Falcón-Ordaz
    Laboratorio de Helmintologia, Instituto de Biologia, UNAM, Ap Postal 70 153, C P 04510, Mexico, D F, Mexico
    J Parasitol 91:329-34. 2005
    ..11 and 12, respectively) and by the absence of a carene at this level...
  84. pmc Identifying rodent hantavirus reservoirs, Brazil
    Akemi Suzuki
    Instituto Adolfo Lutz São Paulo, Sao Paulo, Brazil
    Emerg Infect Dis 10:2127-34. 2004
    ..Our genetic data indicate that Araraquara virus is associated with Bolomys lasiurus (hairy-tailed Bolo mouse) and the Juquitiba-like virus is associated with Oligoryzomys nigripes (black-footed pigmy rice rat)...
  85. ncbi The complex ecology of hantavirus in Paraguay
    Yong Kyu Chu
    Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, New Mexico, USA
    Am J Trop Med Hyg 69:263-8. 2003
    ..These results suggest that several different hantaviruses are co-circulating in Paraguay, and that HPS cases occurring in eastern Paraguay may result from exposure to hantaviruses that are distinct from those in the Chaco...
  86. ncbi The phylogenetic position of the zokors (Myospalacinae) and comments on the families of muroids (Rodentia)
    Ryan W Norris
    Department of Biology, University of Vermont, Burlington, VT 05405, USA
    Mol Phylogenet Evol 31:972-8. 2004
    ..Finally, our analyses suggest that the earlier placement of Myospalax as a member of the Cricetinae is the result of a single misidentified specimen, which was not a Myospalax...
  87. ncbi Dental microwear in relation to changes in the direction of mastication during the evolution of Myodonta (Rodentia, Mammalia)
    Cyril Charles
    Laboratoire de Géobiologie, Biochronologie et Paléontologie humaine, CNRS UMR 6046, Faculté SFA, Universite de Poitiers, 40, avenue du Recteur Pineau, 86022 Poitiers Cedex, France
    Naturwissenschaften 94:71-5. 2007
    ..in molar tooth crown morphology and the direction of masticatory movement during the evolution of Myodonta (Rodentia, Mammalia)...
  88. doi Karyotypic and molecular polymorphisms in Ctenomys torquatus (Rodentia: Ctenomyidae): taxonomic considerations
    Fabiano A Fernandes
    PPG Biologia Animal, Departamento de Zoologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Genetica 136:449-59. 2009
    ..from Corrientes, Argentina, is described by means of mtDNA cytochrome b analysis. Although both entities share similar karyotypes and sperm morphology, these two species are not phylogenetically close...
  89. ncbi Infection of Calomys callosus (Rodentia Cricetidae) with strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis induction
    Isis Fernandes Magalhães-Santos
    Laboratório de Doença de Chagas Experimental, Autoimunidade e Imunologia Celular e Laboratório de Patologia Experimental, Centro de Pesquisas Gonçalo Moniz FIOCRUZ, Rua Valdemar Falcão 121, 40295 001 Salvador, BA, Brazil
    Mem Inst Oswaldo Cruz 99:407-13. 2004
    ..The results confirm the importance of the different biodemes in the determination of tissue lesions and the peculiarities of response of C. callosus to infection with T. cruzi...
  90. ncbi Age structure, residents, and transients of Miocene rodent communities
    Albert J van der Meulen
    Faculty of Earth Sciences, Utrecht University, Budapestlaan 4, 3584 CD Utrecht, The Netherlands
    Am Nat 165:E108-25. 2005
    ..We view the system within the context of nonequilibrium metapopulation theory, in which competitively superior species become transients because of their dependence on ephemeral late successional habitats...
  91. doi The evolution of ecomorphological traits within the Abrothrichini (Rodentia: Sigmodontinae): a Bayesian phylogenetics approach
    Enrique Rodríguez-Serrano
    Laboratorio de Biología Evolutiva, Departamento de Ecologia, Facultad de Ciencias Biologicas, and Center for Advanced Studies in Ecology and Biodiversity, Pontificia Universidad Catolica de Chile, Casilla 114 D, Santiago 6513677, Chile
    Mol Phylogenet Evol 48:473-80. 2008
    ..the ancestral trait of fossoriality, and ancestral distributions of species belonging to the Andean Clade (Rodentia: Sigmodontinae)...
  92. ncbi Ecologic correlates of Toxoplasma gondii exposure in free-ranging neotropical mammals
    Benoit de Thoisy
    Parasitologie Mycologie, EA 3593, UFR Médecine Antilles Guyane, BP 6006, F 97306 Cayenne, French Guiana
    J Wildl Dis 39:456-9. 2003
    ..Terrestrial mammals were significantly more exposed to T. gondii than other mammals. This result is concordant with oral exposure to T. gondii related to ground dwelling behavior and/or carnivory...
  93. pmc Field and laboratory studies provide insights into the meaning of day-time activity in a subterranean rodent (Ctenomys aff. knighti), the tuco-tuco
    Barbara M Tomotani
    Departamento de Fisiologia, Instituto de Biociencias, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 7:e37918. 2012
    ....
  94. ncbi Seasonal variation in prevalence of antibody to hantaviruses in rodents from southern Argentina
    G Cantoni
    , , Argentina
    Trop Med Int Health 6:811-6. 2001
    ..For an HPS case that occurred in our study area in 1997, we identified the probable rodent reservoir and likely site of exposure by matching the genetic sequences of virus obtained from a rodent and the HPS case patient...
  95. doi [Spread of Leishmania major to the north of Algeria]
    A Boudrissa
    Institut Pasteur d Algerie, Route du petit Staoueli, Dely Ibrahim, Alger, Algerie
    Bull Soc Pathol Exot 105:30-5. 2012
    ..major from the arid zones towards the semi arid areas, particularly in the Soummam valley. Climate changes and desertification observed in the steppe area northern Sahara could play a role in the extension of the disease...
  96. ncbi Genome composition in Venezuelan spiny-rats of the genus Proechimys(Rodentia, Echimyidae). I. Genome size, C-heterochromatin and repetitive DNAs in situ hybridization patterns
    S Garagna
    Dipartimento di Biologia Animale e Centro di Studio per l Istochimica del CNR, Universita di Pavia, Italy
    Cytogenet Cell Genet 78:36-43. 1997
    ....
  97. pmc Mitochondrial genomes reveal slow rates of molecular evolution and the timing of speciation in beavers (Castor), one of the largest rodent species
    Susanne Horn
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS ONE 6:e14622. 2011
    ..Little is known about their evolution and even their closest phylogenetic relatives have not yet been identified with certainty. Similarly, little is known about the timing of divergence events within the genus Castor...
  98. ncbi Delayed compensation for missing keystone species by colonization
    S K Ernest
    Department of Biology, University of New Mexico, Albuquerque, NM 87131 USA
    Science 292:101-4. 2001
    ..These results demonstrate the importance of individual species and of colonization and extinction events in the structure and dynamics of ecosystems...
  99. ncbi The conservation status of the tuco-tucos, genus Ctenomys (Rodentia: Ctenomyidae), in southern Brazil
    F A Fernandes
    Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Braz J Biol 67:839-47. 2007
    ..The implications of the data on these species from the Southeastern Brazil are also discussed in relation to the evolution and risk of extinction of these subterranean rodents...
  100. pmc Coexistence of pathogens in host-seeking and feeding ticks within a single natural habitat in Central Germany
    Jan Franke
    Department of Food and Environmental Hygiene, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Str 29, 07743 Jena, Germany
    Appl Environ Microbiol 76:6829-36. 2010
    ..Our results suggest that birds not only are important reservoirs for several pathogens but also act as vehicles for infected ticks and might therefore play a key role in the dispersal of tick-borne diseases...
  101. ncbi Phylogeny of rodentia (Mammalia) inferred from the nuclear-encoded gene IRBP
    R W DeBry
    Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221 0006, USA
    Mol Phylogenet Evol 19:290-301. 2001
    The order Rodentia includes nearly half of all living mammalian species. Phylogenetic relationships among 22 species of rodents were investigated by use of a 1.2-kb region from exon 1 of the single-copy nuclear gene IRBP...

Research Grants70

  1. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  2. Xenoestrogen regulation of Leydig cells
    BENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010
    ..Research training to be afforded by the present application to professional veterinary students will contribute to efforts geared to preparing future veterinarians to meet these challenges. ..
  3. Brain Activation responses in adolescents with genetic predisposition to obesity
    Susan Carnell; Fiscal Year: 2011
    ..The results may lead to new drugs and interventions to improve eating behavior, and help establish unbiased indicators of obesity risk and prognosis for use in research and clinical settings. ..
  4. Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..A better understanding of factors involved in insulin resistance should enable development of therapeutic targets to help prevent diabetes and cardiovascular disease. ..
  5. Neurobehavioral Correlates of Familial/genetic obesity risk in adolescents
    Susan Carnell; Fiscal Year: 2013
    ..abstract_text> ..
  6. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
    ....
  7. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
    ....
  8. Mitochondrial dysfunction, oxidative stress, and surgical acute kidney injury
    FREDERIC TREMAINE BILLINGS; Fiscal Year: 2013
    ..Strong institutional investment in the candidate optimizes his likelihood of progressing to independence and impacting on adverse effects of surgery. ..
  9. Systemic Inflammation and Central Nervous System Dysfunction
    Laura L Dugan; Fiscal Year: 2013
    ..abstract_text> ..
  10. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ....
  11. Osteocalcin and Metabolic Risk Factors. The Framingham Study
    Yi Hsiang Hsu; Fiscal Year: 2011
    ....
  12. Drug Interactions at the Human Blood-Brain Barrier
    Jashvant D Unadkat; Fiscal Year: 2010
    ..In addition, our studies will measure the magnitude of such interactions. The results of our study should lead to better management of drug therapy and improvement of the drug development process. ..
  13. Thyroid Hormone Action
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ....
  14. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    ..Studies are proposed in this application to study the role of virus-like sequences in the onset and progression of environmentally-induced atherosclerosis in experimental systems. ..
  15. Transgenerational effects of endocrine disruptors: epigenetics and physiology
    Rebecca A Simmons; Fiscal Year: 2013
    ..The proof of the principle of prenatal programming by environmental contaminants may change our awareness of critical assessment of the risk of such compounds. ..
  16. Role of the kallikrein-kinin system in diabetic retinopathy
    Edward P Feener; Fiscal Year: 2012
    ..These studies could reveal new therapeutic strategies to treat diabetic macular edema, a leading cause of vision loss. ..
  17. Efficacy of GABAA a5 receptor inverse agonists in learning impaired rats
    EARL MICHAEL GIBBS; Fiscal Year: 2010
    ..Patients with learning disorders and those suffering from complications due to neurodegenerative diseases will greatly benefit as PWZ-029 moves another step closer to the clinic. ..
  18. Transplatin: A Novel Agent to Mitigate Cisplatin Toxicity
    Vickram Ramkumar; Fiscal Year: 2013
    ..Overall, we believe that this study will provide the basis for the use of transplatin to alleviate cisplatin toxicities in cancer patients. ..
  19. Neuroimaging Assessments of Brain Integrity in Aging Mice
    Ai Ling Lin; Fiscal Year: 2013
    ..Translational neuroimaging is an emerging field with extraordinary promise. My ambition is to become pioneer in this emerging discipline. ..
  20. Interaction between RNA interference and RNA editing pathways
    Kazuko Nishikura; Fiscal Year: 2013
    ..Our research focuses also on apoptosis, which is highly relevant to many human diseases including cancer. ..
  21. Effects of In Utero and Transgenerational Exposure of Avy Mice to Bisphenol A
    CHERYL SUSAN ROSENFELD; Fiscal Year: 2010
    ..abstract_text> ..
  22. Mechanisms of Bone Loss from Administration of the Second-Generation Antipsychoti
    KATHERINE JEAN MOTYL; Fiscal Year: 2013
    ..My results will also add to the increasing evidence for a key role of the nervous system in regulating skeletal homeostasis. ..
  23. Killed But Metabolically Active Leishmania: a novel protozoan vaccine technology
    Noah Craft; Fiscal Year: 2009
    ..If effective, this technology could potentially be applied to other infectious agents such as malaria and tuberculosis in the future. ..
  24. Mechanisms of Angiogenesis in Retinopathy of Prematurity
    Mary Elizabeth Hartnett; Fiscal Year: 2009
    ..g., dihydroethidium);and NADPH oxidase activation. ..
  25. Mechanism of Age-Related Change in Estrogen Receptor Beta Expression in Rat Brain
    JENNE MITCHELL WESTBERRY; Fiscal Year: 2012
    ..Furthermore, we will develop a new methodology that will be critical for examining epigenetic changes in gene expression in a temporal and spatial manner in neural tissue with heterogeneous cell populations. ..
  26. MECHANISMS OF MILK LIPID SECRETION
    JAMES LEWIS MCMANAMAN; Fiscal Year: 2013
    ....
  27. Role of beta-endorphin in cancer therapy induced fatigue
    David E Fisher; Fiscal Year: 2013
    ..This 2-endorphin - fatigue axis offers a profound treatment opportunity to improve quality of life in cancer patients, which we will examine in a human clinical trial and a series of preclinical animal studies. ..
  28. SYSTEM FOR AUTOMATED NONINVASIVE MONITORING OF MOUSE SLEEP AND BEHAVIOR
    Sridhar Sunderam; Fiscal Year: 2013
    ..Potential clients include academic research labs as well as industrial labs interested in behavioral monitoring on a large scale (e.g. drug screening), and upgrades to existing users. ..
  29. Chemical Biology Studies of 3-Iodothyronamine and Related Thyroid Hormone Metabol
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..4) Determine the mechanism of intracellular uptake of T1AM and search for T1AM target proteins. ..
  30. Mechanisms of Angiogenesis of Retinopathy of Prematurity
    MARY ELIZABETH RUTH HARTNETT; Fiscal Year: 2013
    ..g., dihydroethidium);and NADPH oxidase activation. ..
  31. Maternal One Carbon Metabolism and Low Birth Weight Infant
    Satish C Kalhan; Fiscal Year: 2013
    ..There are major public health and economic implications for this study, when one considers the enormous magnitude of the LBW, the associated clinical problems and the economic burden to the society. ..
  32. Regulation of Triglyceride Metabolism by the transcription factor CREB-H
    Ann Hwee Lee; Fiscal Year: 2013
    ....
  33. Design and Synthesis of Anxioselective Anxiolytics
    James M Cook; Fiscal Year: 2010
    ..This latter research may also have implications in Alzheimer's disease and schizophrenia. ..
  34. Adipose Tissue Macrophage Phenotype and Function
    Anthony W Ferrante; Fiscal Year: 2013
    ....
  35. RNA interference therapy for Huntington's disease: studies in non-human primates
    Beverly L Davidson; Fiscal Year: 2010
    ..This work is a collaborative effort between laboratories at the University of Iowa and the Oregon National Primate Research Center at the Oregon Health Sciences University. ..
  36. Beta-cell Compensation in Partial Pancreatectomy Mice
    JOHN L LEAHY; Fiscal Year: 2013
    ..abstract_text> ..
  37. Identifying underlying mechanisms of intracellular changes in response to caregiv
    MELANIE SARAH FLINT; Fiscal Year: 2013
    ..The data obtained will be critical in identifying caregivers at risk for negative outcomes to improve overall caregiver health. ..
  38. Glutathione in mitochondrial dysfunction and disease progression in ALS-models
    Marcelo R Vargas; Fiscal Year: 2011
    ..One will also investigate possible ways to restore normal mitochondrial function as a therapy for ALS. ..
  39. Pathophysiology and Animal Model of Restless Legs Syndrome (RLS): Btbd9 Null Mic
    Yuqing Li; Fiscal Year: 2010
    ..The results should ultimately aid the development of therapeutic treatments for Restless Legs Syndrome patients. ..
  40. Green Tea and Reduction of Breast Cancer Risk
    MINDY SUSAN KURZER; Fiscal Year: 2013
    ..The development of a viable non-toxic chemoprevention strategy targeting high risk women could have a significant impact on breast cancer morbidity and mortality. ..
  41. Novel PPAR-Independent Peroxisome Proliferators for Type 2 Diabetes
    LIDIA NIEROBISZ; Fiscal Year: 2011
    ..We propose to develop novel PPAR-Independent Peroxisome Proliferators for Type 2 Diabetes to address this market need. ..
  42. Nanomedicine and NeuroAIDS
    Howard E Gendelman; Fiscal Year: 2013
    ..The overall premise is to develop the necessary "state of the art" tools to improve nanoART induced viral reduction in its CNS and other viral reservoirs. ..
  43. GM-CSF analogs for treating acute radiation syndrome
    GEORGE NORBERT COX; Fiscal Year: 2010
    ..Our long-acting GM-CSF analog may prove useful for improving survival in people exposed to an otherwise lethal dose of radiation as a result of a radiological/nuclear disaster. ..
  44. Remodeling of Lipid Metabolism by Dietary Methionine Restriction
    ERIC PAUL PLAISANCE; Fiscal Year: 2012
    ....
  45. Epigenetic Regulation Of Sex-dependent Liver Cancer
    Arlin B Rogers; Fiscal Year: 2012
    ..These studies are the first to define epigenetic modifiers of liver sexual differentiation, and to interrogate a novel mechanism of gender-specific tumor promotion predicated on chromatin sensitivity to inflammation. ..
  46. Organismal Radioprotection Through Pharmacological Quiescence
    JOHN S CHANT; Fiscal Year: 2010
    ..G-Zero Therapeutics is developing drugs which can be stockpiled and easily administered following such an attack to protect the bone marrow from the damaging effects of radiation. ..
  47. Interactions Between Depression, Neuroinflammation and Glycogen Synthase Kinase-3
    Eleonore Beurel; Fiscal Year: 2011
    ..The goals are to clarify potential causative mechanisms and discern how these are altered by therapeutic interventions with the aim of developing better therapeutic interventions for mood disorders. ..
  48. Lipid Metabolism and Steatosis in Liver
    Amrita Kamat; Fiscal Year: 2013
    ..The study is expected to have an important impact by defining new molecular targets for the prevention and/or treatment of NAFLD and its complications. ..
  49. Structure-function analyses on novel processes of type II vestibular hair cells
    Jennifer S Stone; Fiscal Year: 2013
    ..Studies of damaged vestibular organs will help uncover the relationship between normal and regenerated hair cells with processes and the potential of regenerated hair cells to restore function in balance and hearing disorders. ..
  50. Effect of bisphenol A exposure on mammary stem cell function and transformation
    Luzhe Sun; Fiscal Year: 2013
    ....
  51. Transcriptional regulation of proteinuria
    SUMANT SINGH CHUGH; Fiscal Year: 2011
    ..This will lead to the development of appropriate treatment strategies in the future. ..
  52. DYSREGULATION OF GSH SYNTHESIS DURING LIVER INJURY AND FIBROSIS
    SHELLY CHI LOO LU; Fiscal Year: 2013
    ....
  53. NEWBORN IRON DEFICIENCY
    Michael K Georgieff; Fiscal Year: 2013
    ....
  54. Gallstone Pancreatitis: Pathogenesis and Treatment
    Isaac Samuel; Fiscal Year: 2012
    ..A better understanding of these processes will help to improve the treatment of this potentially fatal condition. ..
  55. Creation of hyperactive transposons for mutagenesis in rodents
    Eric M Ostertag; Fiscal Year: 2011
    ..Thus, if successful, this project would benefit many goals of public health by making the production of mutations in the rat that model human diseases readily accessible to the research community. ..
  56. Neuroendocrine Response to Gastric Bypass in Nonhuman Primates
    Randy J Seeley; Fiscal Year: 2010
    ....
  57. Stem cell-mediated delivery of neurotrophic factors for treatment of glaucoma
    Donald S Sakaguchi; Fiscal Year: 2010
    ..Furthermore, these cells can survive in the environment of the eye and have the ability to integrate within the inner retina to serve as delivery vehicles for therapeutic proteins. ..
  58. PET TUMOR AND PROLIFERATION IMAGING VIA CATIONIC AMINO ACID TRANSPORT
    JONATHAN EDWARD MCCONATHY; Fiscal Year: 2013
    ..Completion of the research and training plan would position me to become an independent investigator at the conclusion of the award period. ..
  59. Neural Control of the Circulation: Sex and Hypertension
    Baojian Xue; Fiscal Year: 2013
    ....
  60. Gross Hall Animal Resource Center
    Susan V Bryant; Fiscal Year: 2010
    ....
  61. Quantitative Assessment of Oxidative Metabolism in Brown Fat
    Otto Muzik; Fiscal Year: 2011
    ..Moreover, these studies will provide important physiological information about fat metabolism that will likely translate into novel pharmacological approaches for the treatment of obesity. ..
  62. Selective Insulin Resistance- Diabetic Cardiovascular Diseases
    George L King; Fiscal Year: 2013
    ....
  63. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..Our findings may be relevant to the pathophysiology of IC and may suggest new therapeutic approaches. ..
  64. HANTAVIRUS ECOLOGY AND DISEASE IN CHILE AND PANAMA
    Gregory Mertz; Fiscal Year: 2009
    ..Finally, serial serosurveys of at-risk human populations in Panama will quantify the impact on human infection associated with spatial-temporal variations in rodent density and movement. ..
  65. Imaging Strategies to Measure Brown Fat and Its Activity
    C Ronald Kahn; Fiscal Year: 2010
    ..Our research will develop the tools to measure the amount and activity of brown fat. This is the first step toward developing new ways to stimulate brown fat to help obese people lose weight and improve their overall health. ..
  66. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
    ..There is not treatment that slows the relentless progression of the disease or that reverses it. In this application, we use an animal model to investigate methods to slow progression and reverse the disease. ..
  67. Study of monkeypox virus in rodents
    R Buller; Fiscal Year: 2005
    ..abstract_text> ..
  68. Parasite/Host Interactions and the Neurobiology of Fear
    Robert Sapolsky; Fiscal Year: 2006
    ..In Specific Aim 3, we will examine the effects of Toxoplasma infection on cell number and volume, and on dendritic morphology in brain regions implicated in the prior two Specific Aims in the effects of Toxo. ..
  69. Neuroprotective Drugs for Spinal Cord Injury
    JEAN WRATHALL; Fiscal Year: 2001
    ..It is presumed that a single volume will be used and the concentration of drug varied, but this is not spelled out. ..
  70. Modeling of Hantavirus Reservoirs in Brazil
    Colleen Jonsson; Fiscal Year: 2009
    ..Isolation of the viruses and the neutralization test requires working with live virus at BSL3. A major effort of this grant will be to transfer the technology to build the BSL3 capacity. ..