hominidae

Summary

Summary: Family of the suborder HAPLORHINI (Anthropoidea) comprising bipedal primate MAMMALS. It includes modern man (HOMO SAPIENS) and the great apes: gorillas (GORILLA GORILLA), chimpanzees (PAN PANISCUS and PAN TROGLODYTES), and orangutans (PONGO PYGMAEUS).

Top Publications

  1. pmc Bayes estimation of species divergence times and ancestral population sizes using DNA sequences from multiple loci
    Bruce Rannala
    Department of Medical Genetics, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Genetics 164:1645-56. 2003
  2. pmc A new malaria agent in African hominids
    Benjamin Ollomo
    Unité des Maladies Virales Emergentes, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    PLoS Pathog 5:e1000446. 2009
  3. ncbi Genetic analyses from ancient DNA
    Svante Paabo
    Max Planck Institute for Evolutionary Anthropology, D 04013 Leipzig, Germany
    Annu Rev Genet 38:645-79. 2004
  4. pmc Widespread genomic signatures of natural selection in hominid evolution
    Graham McVicker
    Department of Genome Sciences, University of Washington, Seattle, WA, USA
    PLoS Genet 5:e1000471. 2009
  5. pmc Out of Africa: modern human origins special feature: isotopic evidence for the diets of European Neanderthals and early modern humans
    Michael P Richards
    Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 106:16034-9. 2009
  6. ncbi Demographic history and genetic differentiation in apes
    Anne Fischer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Curr Biol 16:1133-8. 2006
  7. ncbi Dental microwear texture analysis shows within-species diet variability in fossil hominins
    Robert S Scott
    1 Department of Anthropology, University of Arkansas, Fayetteville, Arkansas 72701, USA 2 These authors contributed equally to this work
    Nature 436:693-5. 2005
  8. ncbi Principles for the virtual reconstruction of hominin crania
    Philipp Gunz
    Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, Germany
    J Hum Evol 57:48-62. 2009
  9. pmc Hominin dispersal into the Nefud Desert and Middle palaeolithic settlement along the Jubbah Palaeolake, Northern Arabia
    Michael D Petraglia
    School of Archaeology, Research Laboratory for Archaeology and the History of Art, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e49840. 2012
  10. ncbi The prehistory of the Arabian peninsula: deserts, dispersals, and demography
    Huw S Groucutt
    School of Archaeology, University of Oxford, UK
    Evol Anthropol 21:113-25. 2012

Detail Information

Publications269 found, 100 shown here

  1. pmc Bayes estimation of species divergence times and ancestral population sizes using DNA sequences from multiple loci
    Bruce Rannala
    Department of Medical Genetics, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Genetics 164:1645-56. 2003
    ..Our estimates, however, are affected by model assumptions as well as data quality. We suggest that reliable estimates have yet to await more data and more realistic models...
  2. pmc A new malaria agent in African hominids
    Benjamin Ollomo
    Unité des Maladies Virales Emergentes, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    PLoS Pathog 5:e1000446. 2009
    ..The risk of transfer and emergence of this new species in humans must be now seriously considered given that it was found in two chimpanzees living in contact with humans and its close relatedness to the most virulent agent of malaria...
  3. ncbi Genetic analyses from ancient DNA
    Svante Paabo
    Max Planck Institute for Evolutionary Anthropology, D 04013 Leipzig, Germany
    Annu Rev Genet 38:645-79. 2004
    ..We also highlight some significant results and areas of promising future research...
  4. pmc Widespread genomic signatures of natural selection in hominid evolution
    Graham McVicker
    Department of Genome Sciences, University of Washington, Seattle, WA, USA
    PLoS Genet 5:e1000471. 2009
    ..Our analyses reveal a dominant role for selection in shaping genomic diversity and divergence patterns, clarify hominid evolution, and provide a baseline for investigating specific selective events...
  5. pmc Out of Africa: modern human origins special feature: isotopic evidence for the diets of European Neanderthals and early modern humans
    Michael P Richards
    Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 106:16034-9. 2009
    ..As Oase 1 was close in time to the last Neanderthals, these data may indicate a significant dietary shift associated with the changing population dynamics of modern human emergence in Europe...
  6. ncbi Demographic history and genetic differentiation in apes
    Anne Fischer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Curr Biol 16:1133-8. 2006
    ..Finally, we find that the extent of genetic differentiation among "subspecies" of chimpanzees and orangutans is comparable to that seen among human populations, calling the validity of the "subspecies" concept in apes into question...
  7. ncbi Dental microwear texture analysis shows within-species diet variability in fossil hominins
    Robert S Scott
    1 Department of Anthropology, University of Arkansas, Fayetteville, Arkansas 72701, USA 2 These authors contributed equally to this work
    Nature 436:693-5. 2005
    ..africanus. This suggests that A. africanus ate more tough foods and P. robustus consumed more hard and brittle items, but that both had variable and overlapping diets...
  8. ncbi Principles for the virtual reconstruction of hominin crania
    Philipp Gunz
    Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, Germany
    J Hum Evol 57:48-62. 2009
    ..While there will typically be shape differences among equally plausible reconstructions, these different estimates might still support a single conclusion...
  9. pmc Hominin dispersal into the Nefud Desert and Middle palaeolithic settlement along the Jubbah Palaeolake, Northern Arabia
    Michael D Petraglia
    School of Archaeology, Research Laboratory for Archaeology and the History of Art, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e49840. 2012
    ..Comparative inter-regional analysis of core technology indicates morphological similarities with the Levantine Tabun C assemblage, associated with human fossils controversially identified as either Neanderthals or Homo sapiens...
  10. ncbi The prehistory of the Arabian peninsula: deserts, dispersals, and demography
    Huw S Groucutt
    School of Archaeology, University of Oxford, UK
    Evol Anthropol 21:113-25. 2012
    ..Debates continue on the respective roles of regional hominin extinctions and population continuity, with the latter suggesting adaptation to arid conditions...
  11. ncbi The biology of the colonizing ape
    Jonathan C K Wells
    Childhood Nutrition Research Centre, Institute of Child Health, London WC1N 1EH, UK
    Am J Phys Anthropol . 2007
    ..We propose that the concept of hominins as "colonizing apes" offers a novel unified model for interpreting the suite of traits characteristic of our genus...
  12. pmc Genomic signatures of diet-related shifts during human origins
    Courtney C Babbitt
    Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    Proc Biol Sci 278:961-9. 2011
    ..Finally, we propose some ways in which new technologies can help identify specific genomic adaptations that have resulted in metabolic and morphological differences between humans and non-human primates...
  13. pmc Late Pleistocene adult mortality patterns and modern human establishment
    Erik Trinkaus
    Department of Anthropology, Washington University, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 108:1267-71. 2011
    ..They indicate only subtle and paleontologically invisible changes in human paleodemographics with the establishment of modern humans; they provide no support for a life history advantage among early modern humans...
  14. ncbi Growth processes in teeth distinguish modern humans from Homo erectus and earlier hominins
    C Dean
    Evolutionary Anatomy Unit, Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 414:628-31. 2001
    ..These times were shorter than those in modern humans. It therefore seems likely that truly modern dental development emerged relatively late in human evolution...
  15. ncbi The prehistory of handedness: archaeological data and comparative ethology
    Natalie T Uomini
    School of Archaeology, Classics and Egyptology, University of Liverpool, UK
    J Hum Evol 57:411-9. 2009
    ..When primatology meets palaeoanthropology, the evidence suggests species-level right-handedness may have emerged through the social transmission of increasingly complex, bimanually differentiated, tool using activities...
  16. ncbi Morphological evolution through integration: a quantitative study of cranial integration in Homo, Pan, Gorilla and Pongo
    Nandini Singh
    Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, Germany
    J Hum Evol 62:155-64. 2012
    ..Thus, despite having very distinct morphologies the way in which the face, basicranium and cranial vault covary is shared among these taxa. These results imply that the pattern of cranial integration among hominoids is conserved...
  17. ncbi An ecomorphological model of the initial hominid dispersal from Africa
    S C Anton
    Center for Human Evolutionary Studies, Department of Anthropology, Rutgers University, New Brunswick, NJ 08901, USA
    J Hum Evol 43:773-85. 2002
    ..erectus facilitated by changes in ecosystem structure during the Plio-Pleistocene...
  18. ncbi Wild great apes as sentinels and sources of infectious disease
    S Calvignac-Spencer
    Emerging Zoonoses, Robert Koch Institut, Berlin, Germany
    Clin Microbiol Infect 18:521-7. 2012
    ..Linking non-invasive diagnostic data with observational health data from great apes habituated to human presence is a promising approach for the discovery of pathogens of high relevance for humans...
  19. ncbi Is Homo heidelbergensis a distinct species? New insight on the Mauer mandible
    Aurélien Mounier
    Unité d Anthropologie Adaptabilité Bioculturelle, UMR 6578, CNRS, Universite de la Mediterranee, EFS, Faculte de Medecine Secteur Nord, Marseille, France
    J Hum Evol 56:219-46. 2009
    ..neanderthalensis and H. sapiens. However, the results of this study fail to entirely discount the hypothesis that considers H. heidelbergensis as a chronospecies leading to the Neandertals...
  20. ncbi Evidence for stone-tool-assisted consumption of animal tissues before 3.39 million years ago at Dikika, Ethiopia
    Shannon P McPherron
    Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, DeutscherPlatz 6, Leipzig 04103, Germany
    Nature 466:857-60. 2010
    ..Our discovery extends by approximately 800,000 years the antiquity of stone tools and of stone-tool-assisted consumption of ungulates by hominins; furthermore, this behaviour can now be attributed to Australopithecus afarensis...
  21. pmc Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA
    Adrian W Briggs
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Nucleic Acids Res 38:e87. 2010
    ..In addition, our results demonstrate that Neandertal DNA retains in vivo patterns of CpG methylation, potentially allowing future studies of gene inactivation and imprinting in ancient organisms...
  22. ncbi The metabolic cost of walking in humans, chimpanzees, and early hominins
    Herman Pontzer
    Washington University, Department of Anthropology, St Louis, MO 63130, USA
    J Hum Evol 56:43-54. 2009
    ..This supports the hypothesis that locomotor energy economy was an important evolutionary pressure on hominin bipedalism...
  23. pmc The feeding biomechanics and dietary ecology of Australopithecus africanus
    David S Strait
    Department of Anthropology, University at Albany, 1400 Washington Avenue, Albany, NY 12222, USA
    Proc Natl Acad Sci U S A 106:2124-9. 2009
    ..Our analysis reconciles apparent discrepancies between dietary reconstructions based on biomechanics, tooth morphology, and dental microwear...
  24. ncbi Using genetic evidence to evaluate four palaeoanthropological hypotheses for the timing of Neanderthal and modern human origins
    Phillip Endicott
    Départment Hommes, Natures, sociétés, Musée de l Homme, Paris, France
    J Hum Evol 59:87-95. 2010
    ..These results suggest that a reappraisal of key elements in the Pleistocene hominin fossil record may now be required...
  25. pmc Out of Africa: modern human origins special feature: the origin of Neandertals
    J J Hublin
    Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 106:16022-7. 2009
    ....
  26. ncbi The evolution of human skin coloration
    N G Jablonski
    Department of Anthropology, California Academy of Sciences, Golden Gate Park, San Francisco, CA 94118 4599, USA
    J Hum Evol 39:57-106. 2000
    ..Skin pigmentation levels have changed more than once in human evolution. Because of this, skin coloration is of no value in determining phylogenetic relationships among modern human groups...
  27. ncbi Human and ape molecular clocks and constraints on paleontological hypotheses
    R L Stauffer
    Department of Biology and Institute of Molecular Evolutionary Genetics, Pennsylvania State University, University Park, PA 16802, USA
    J Hered 92:469-74. 2001
    ..3 +/- 1.3 million years ago (orangutan, 33 genes), and 14.9 +/- 2.0 million years ago (gibbon, 27 genes). Based on these molecular constraints, we find that several proposed phylogenies of fossil hominoid taxa are unlikely to be correct...
  28. pmc Comparative and familial analysis of handedness in great apes
    William D Hopkins
    Department of Psychology, Berry College and Yerkes National Primate Research Center, Atlanta, GA 30322, USA
    Psychol Bull 132:538-59. 2006
    ..Overall, the proportion of right handedness is lower in great apes compared with humans, and various methodological and theoretical explanations for this discrepancy are discussed...
  29. ncbi Inferring hominoid and early hominid phylogeny using craniodental characters: the role of fossil taxa
    David S Strait
    Department of Anthropology, University at Albany, 1400 Washington Avenue, Albany, NY, 12222, USA
    J Hum Evol 47:399-452. 2004
    ..garhi is either the sister taxon or direct ancestor of the genus Homo. Phylogenetic relationships indicate that Australopithecus is paraphyletic. Thus, A. anamensis and A. garhi should be allocated to new genera...
  30. ncbi Early evidence of the genus Homo in East Asia
    R X Zhu
    Paleomagnetism and Geochronology Laboratory SKL LE, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China
    J Hum Evol 55:1075-85. 2008
    ..The age and location are consistent with a rapid southern migration route of initial hominin populations into Eastern Asia...
  31. pmc Nuts, nut cracking, and pitted stones at Gesher Benot Ya'aqov, Israel
    Naama Goren-Inbar
    Institute of Archaeology, Hebrew University of Jerusalem, Mt Scopus, Jerusalem 91905, Israel
    Proc Natl Acad Sci U S A 99:2455-60. 2002
    ..The evidence also sheds light on the structure of the community: ethnographic analogies suggest that mixedgender groups may have been active on the shores of paleoLake Hula...
  32. ncbi The diets of early hominins
    Peter S Ungar
    Department of Anthropology, University of Arkansas, Fayetteville, AR 72701, USA
    Science 334:190-3. 2011
    ..g., seeds and nuts) consumption dates to millions of years after the appearance of the earliest probable hominins, and there are no consistent trends in diet change among these species through time...
  33. pmc An Early Pleistocene hominin mandible from Atapuerca-TD6, Spain
    E Carbonell
    Area de Prehistoria, Universitat Rovira i Virgili, Plaza Imperial Tarraco 1, 43005 Tarragona, Spain
    Proc Natl Acad Sci U S A 102:5674-8. 2005
    ..This evidence reinforces the taxonomic identity of H. antecessor and is consistent with the hypothesis of a close relationship between this species and Homo sapiens...
  34. pmc Hand preferences for coordinated bimanual actions in 777 great apes: implications for the evolution of handedness in hominins
    William D Hopkins
    Department of Psychology, Agnes Scott College, 141 E College Avenue, Decatur, GA 30030, USA
    J Hum Evol 60:605-11. 2011
    ....
  35. ncbi Systematic blade production at late Lower Paleolithic (400-200 kyr) Qesem Cave, Israel
    Ron Shimelmitz
    Institute of Archaeology, Tel Aviv University, Tel Aviv 69978, Israel
    J Hum Evol 61:458-79. 2011
    ..Furthermore, this well-organized serial manufacture of cutting implements mainly for butchering might indicates that a significant change in human behavior had taken place by the late Lower Paleolithic period...
  36. pmc Dental evidence on the hominin dispersals during the Pleistocene
    M Martinón-Torres
    Centro Nacional de Investigación sobre la Evolución Humana, Avenida de la Paz 28, 09004 Burgos, Spain
    Proc Natl Acad Sci U S A 104:13279-82. 2007
    ..We propose that the genetic impact of Asia in the colonization of Europe during the Early and Middle Pleistocene was stronger than that of Africa...
  37. pmc Strong reproductive isolation between humans and Neanderthals inferred from observed patterns of introgression
    Mathias Currat
    Anthropology, Genetics, and Peopling History Laboratory, Anthropology Unit, Department of Genetics and Evolution, University of Geneva, 1227 Geneva, Switzerland
    Proc Natl Acad Sci U S A 108:15129-34. 2011
    ..This hypothesis could be tested because it predicts that different components of Neanderthal ancestry should be present in Europeans and in Asians...
  38. pmc Fossils, feet and the evolution of human bipedal locomotion
    W E H Harcourt-Smith
    Division of Vertebrate Paleontology, American Museum of Natural History, New York 10024, USA
    J Anat 204:403-16. 2004
    ....
  39. pmc Laetoli footprints preserve earliest direct evidence of human-like bipedal biomechanics
    David A Raichlen
    School of Anthropology, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 5:e9769. 2010
    ..Determining the kinematics of Laetoli hominins will allow us to understand whether selection acted to decrease energy costs of bipedalism by 3.6 Ma...
  40. pmc Archaic lineages in the history of modern humans
    D Labuda
    Department of Pediatrics, University of Montreal, Montreal, Quebec H3T 1C5, Canada
    Genetics 156:799-808. 2000
    ..Genetic admixture involving archaic lineages appears therefore to have occurred within Africa rather than outside this continent, explaining greater diversity of sub-Saharan populations observed in a variety of genetic systems...
  41. pmc Microstratigraphic evidence of in situ fire in the Acheulean strata of Wonderwerk Cave, Northern Cape province, South Africa
    Francesco Berna
    Department of Archaeology, Boston University, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 109:E1215-20. 2012
    ..0 Ma. To the best of our knowledge, this is the earliest secure evidence for burning in an archaeological context...
  42. pmc Possible brucellosis in an early hominin skeleton from sterkfontein, South Africa
    Ruggero D'Anastasio
    Department of Human Movement Sciences, Section of Anthropology, State University G d Annunzio, Chieti, Italy
    PLoS ONE 4:e6439. 2009
    ..Now with the hypothesis of brucellosis in A. africanus, we may have evidence of occasional meat eating directly linked to a fossil hominin...
  43. ncbi Early hominid stone tool production and technical skill 2.34 Myr ago in West Turkana, Kenya
    H Roche
    CNRS, Préhistoire et Technologie, MAE boite 3, Nanterre, France
    Nature 399:57-60. 1999
    ..We can thus demonstrate greater cognitive capacity and motor skill than previously assumed for early hominids, and highlight the diversity of Pliocene technical behaviour...
  44. ncbi Paleobiological implications of the Ardipithecus ramidus dentition
    Gen Suwa
    University Museum, University of Tokyo, Hongo, Bunkyo ku, Tokyo, 113 0033 Japan
    Science 326:94-9. 2009
    ..The canine/lower third premolar complex indicates a reduction of canine size and honing capacity early in hominid evolution, possibly driven by selection targeted on the male upper canine...
  45. ncbi New estimates of tooth mark and percussion mark frequencies at the FLK Zinj site: the carnivore-hominid-carnivore hypothesis falsified
    M Dominguez-Rodrigo
    Departamento de Prehistoria, Universidad Complutense, 28040, Madrid, Spain
    J Hum Evol 50:170-94. 2006
    ....
  46. ncbi Late Miocene teeth from Middle Awash, Ethiopia, and early hominid dental evolution
    Yohannes Haile-Selassie
    Cleveland Museum of Natural History, 1 Wade Oval Drive, Cleveland, OH 44106, USA
    Science 303:1503-5. 2004
    ..kadabba. It is therefore premature to posit extensive late Miocene hominid diversity on the basis of currently available samples...
  47. ncbi A new species of great ape from the late Miocene epoch in Ethiopia
    Gen Suwa
    The University Museum, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 448:921-4. 2007
    ..The combined evidence suggests that Chororapithecus may be a basal member of the gorilla clade, and that the latter exhibited some amount of adaptive and phyletic diversity at around 10-11 Myr ago...
  48. ncbi Tool-composite reuse in wild chimpanzees (Pan troglodytes): archaeologically invisible steps in the technological evolution of early hominins?
    Susana Carvalho
    Leverhulme Centre for Human Evolutionary Studies, Department of Biological Anthropology, University of Cambridge, Cambridge, UK
    Anim Cogn 12:S103-14. 2009
    ....
  49. ncbi Optimal running speed and the evolution of hominin hunting strategies
    Karen L Steudel-Numbers
    Department of Zoology, University of Wisconsin, Madison, WI 53706, USA
    J Hum Evol 56:355-60. 2009
    ..Variations in the efficiency of human locomotion appear to be similar to those of terrestrial quadrupeds...
  50. pmc Genetic evidence for patrilocal mating behavior among Neandertal groups
    Carles Lalueza-Fox
    Institute of Evolutionary Biology, Consejo Superior de Investigaciones Cientificas Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Proc Natl Acad Sci U S A 108:250-3. 2011
    ..These findings provide evidence to indicate that Neandertal groups not only were small and characterized by low genetic diversity but also were likely to have practiced patrilocal mating behavior...
  51. pmc Human-like external function of the foot, and fully upright gait, confirmed in the 3.66 million year old Laetoli hominin footprints by topographic statistics, experimental footprint-formation and computer simulation
    Robin H Crompton
    Institute of Aging and Chronic Disease, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, UK
    J R Soc Interface 9:707-19. 2012
    ..66 Mya. This finding provides strong support to those previous studies which have interpreted the G-1 prints as generally modern in aspect...
  52. ncbi Taphonomic perspectives on hominid site use and foraging strategies during Bed II times at Olduvai Gorge, Tanzania
    Charles P Egeland
    Department of Anthropology, University of Wisconsin, Madison, USA
    J Hum Evol 55:1031-52. 2008
    ....
  53. ncbi Anthropology: the earliest toothless hominin skull
    David Lordkipanidze
    Georgian State Museum, Tbilisi 0105, Georgia
    Nature 434:717-8. 2005
    ..This specimen not only represents the earliest case of severe masticatory impairment in the hominin fossil record to be discovered so far, but also raises questions about alternative subsistence strategies in early Homo...
  54. ncbi Global genetic variation at OAS1 provides evidence of archaic admixture in Melanesian populations
    Fernando L Mendez
    Department of Ecology and Evolutionary Biology, University of Arizona, USA
    Mol Biol Evol 29:1513-20. 2012
    ....
  55. ncbi Surprisingly rapid growth in Neanderthals
    Fernando V Ramirez Rozzi
    UPR 2147, Dyamique de l Evolution Humaine, CNRS, 44, rue de l Amiral Mouchez, 75014 Paris, France
    Nature 428:936-9. 2004
    ..This autapomorphy in growth is an evolutionary reversal, and points strongly to a specific distinction between H. sapiens and H. neanderthalensis...
  56. ncbi A closer look at Neanderthal postcanine dental morphology: the mandibular dentition
    Shara E Bailey
    Division of Anthropology, American Museum of Natural History, Central Park West at 79th Street, New York, NY 10024 5192, USA
    Anat Rec 269:148-56. 2002
    ..Interestingly, these characters are not observed in the Mauer mandible, which some have claimed to be a member of a chronospecies that is a unique ancestor to Neanderthals...
  57. ncbi Spatial organization of hominin activities at Gesher Benot Ya'aqov, Israel
    Nira Alperson-Afil
    Institute of Archaeology, Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
    Science 326:1677-80. 2009
    ..The diversity of human activities and the distinctive patterning with which they are organized implies advanced organizational skills of the Gesher Benot Ya'aqov hominins...
  58. pmc BC200 RNA: a neural RNA polymerase III product encoded by a monomeric Alu element
    J A Martignetti
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029
    Proc Natl Acad Sci U S A 90:11563-7. 1993
    ..Our data on conserved features of the active BC200 alpha gene suggest that its RNA product has been "exapted" into a function of the primate brain and provides a selective advantage to the species...
  59. ncbi Evolution of middle-late Pleistocene human cranio-facial form: a 3-D approach
    Katerina Harvati
    Department of Early Prehistory and Quaternary Ecology and Senckenberg Center for Human Evolution and Paleoecology, Eberhard Karls Universitat Tubingen, Rümelinstr 23, 72070 Tübingen, Baden Württenberg, Germany
    J Hum Evol 59:445-64. 2010
    ....
  60. pmc On the earliest evidence for habitual use of fire in Europe
    Wil Roebroeks
    Faculty of Archaeology, Leiden University, 2300 RA Leiden, The Netherlands
    Proc Natl Acad Sci U S A 108:5209-14. 2011
    ..The increase in the number of sites with good evidence of fire throughout the Late Pleistocene shows that European Neandertals had fire management not unlike that documented for Upper Paleolithic groups...
  61. ncbi The mammalian fauna associated with an archaic hominin skullcap and later Acheulean artifacts at Elandsfontein, Western Cape Province, South Africa
    Richard G Klein
    Program in Human Biology, Stanford University, Building 80, Inner Quad, Stanford, CA 94305, USA
    J Hum Evol 52:164-86. 2007
    ..Together with limited observations from other sites, Elandsfontein and Duinefontein provisionally suggest that Acheulean-age hominins obtained few large mammals, whether by hunting or scavenging...
  62. pmc Cooperative hunting and meat sharing 400-200 kya at Qesem Cave, Israel
    Mary C Stiner
    School of Anthropology, University of Arizona, Tucson, AZ 85721 0030, USA
    Proc Natl Acad Sci U S A 106:13207-12. 2009
    ..The results from Qesem Cave raise new hypotheses about possible differences in the mechanics of meat sharing between the late Lower Paleolithic and Middle Paleolithic...
  63. ncbi At the end of the 14C time scale--the Middle to Upper Paleolithic record of western Eurasia
    Olaf Jöris
    Forschungsbereich Altsteinzeit des Römisch Germanischen Zentralmuseums, Schloss Monrepos, D 56567 Neuwied, Germany
    J Hum Evol 55:782-802. 2008
    ..33.0/32.5-29.2 ka 14C BP. Taken together, the Middle to Upper Paleolithic transition appears to be a cumulative process involving the acquisition of different elements of "behavioral modernity" through several "stages of innovation."..
  64. ncbi Functional ecology and evolution of hominoid molar enamel thickness: Pan troglodytes schweinfurthii and Pongo pygmaeus wurmbii
    Erin R Vogel
    Department of Anthropology, 1156 High Street, University of California Santa Cruz, CA 95064, United States
    J Hum Evol 55:60-74. 2008
    ..These data, which are among the first reported for hominoid primates, fill an important empirical void for evaluating the mechanical plausibility of putative hominin food objects...
  65. pmc Three-dimensional molar enamel distribution and thickness in Australopithecus and Paranthropus
    A J Olejniczak
    Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Biol Lett 4:406-10. 2008
    ..The three-dimensional distribution of enamel thickness shows different patterns among species, and is more useful for the interpretation of functional adaptations than single summary measures of enamel thickness...
  66. ncbi Brain-specific lipids from marine, lacustrine, or terrestrial food resources: potential impact on early African Homo sapiens
    C Leigh Broadhurst
    US Department of Agriculture, Environmental Chemistry Laboratory, Agricultural Research Service, Beltsville, MD 20705, USA
    Comp Biochem Physiol B Biochem Mol Biol 131:653-73. 2002
    ....
  67. ncbi Molar microwear in Praeanthropus afarensis: evidence for dietary stasis through time and under diverse paleoecological conditions
    Frederick E Grine
    Department of Anthropology, Stony Brook University, NY 11794, USA
    J Hum Evol 51:297-319. 2006
    ....
  68. ncbi Who made the Aurignacian and other early Upper Paleolithic industries?
    Shara E Bailey
    Department of Anthropology, New York University, 25 Waverly Place, New York, NY 10003, USA
    J Hum Evol 57:11-26. 2009
    ..These results provide some of the strongest evidence that anatomically modern humans made the Aurignacian and other (non-Châtelperronian) early Upper Paleolithic industries...
  69. ncbi BAGE genes generated by juxtacentromeric reshuffling in the Hominidae lineage are under selective pressure
    Myriam Ruault
    Institut de Genetique Humaine, CNRS UPR 1142, 141, rue de la Cardonille, 34396 Montpellier, France
    Genomics 81:391-9. 2003
    ..Our data strongly suggest that BAGE proteins have a function and that juxtacentromeric regions, whose plasticity is now largely proved, are not a simple junkyard of gene fragments, but may be the birth site of novel genes...
  70. ncbi 40Ar/(39)Ar dating of the Kapthurin Formation, Baringo, Kenya
    Alan L Deino
    Berkeley Geochronology Center, 2455 Ridge Road, Berkeley, CA 94709, USA
    J Hum Evol 42:185-210. 2002
    ..The presence of blades and red ochre at this depth is important as blades signify a high degree of technical competence and red ochre suggests symbolic behavior...
  71. ncbi Variations in molar enamel thickness among primates
    R P Shellis
    MRC Dental Group Dental School, Lower Maudlin Street, Bristol, BS1 2LY, U K
    J Hum Evol 35:507-22. 1998
    ..These results may be relevant to considerations of hominoid evolution...
  72. pmc Molar microwear textures and the diets of Australopithecus anamensis and Australopithecus afarensis
    Peter S Ungar
    Department of Anthropology, University of Arkansas, Old Main 330, Fayetteville, AR 72701, USA
    Philos Trans R Soc Lond B Biol Sci 365:3345-54. 2010
    ....
  73. ncbi The great divides: Ardipithecus ramidus reveals the postcrania of our last common ancestors with African apes
    C Owen Lovejoy
    Department of Anthropology, School of Biomedical Sciences, Kent State University, Kent, OH 44242 0001, USA
    Science 326:100-6. 2009
    ..The specialized locomotor anatomies and behaviors of chimpanzees and gorillas therefore constitute poor models for the origin and evolution of human bipedality...
  74. ncbi Middle Paleolithic assemblages from the Indian subcontinent before and after the Toba super-eruption
    Michael Petraglia
    Leverhulme Centre for Human Evolutionary Studies, University of Cambridge, Cambridge CB2 1QH, UK
    Science 317:114-6. 2007
    ..Broad continuity of Middle Paleolithic technology across the YTT event suggests that hominins persisted regionally across this major eruptive event...
  75. pmc Alu elements and hominid phylogenetics
    Abdel Halim Salem
    Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803, USA
    Proc Natl Acad Sci U S A 100:12787-91. 2003
    ..of Alu Ye5 elements and elements from several other subfamilies reveals high levels of support for monophyly of Hominidae, tribe Hominini and subtribe Hominina...
  76. ncbi The 'human revolution' in lowland tropical Southeast Asia: the antiquity and behavior of anatomically modern humans at Niah Cave (Sarawak, Borneo)
    Graeme Barker
    McDonald Institute for Archaeological Research, University of Cambridge, Downing Street, Cambridge CB2 3ER, UK
    J Hum Evol 52:243-61. 2007
    ..The Niah evidence demonstrates the sophisticated nature of the subsistence behavior developed by modern humans to exploit the tropical environments that they encountered in Southeast Asia, including rainforest...
  77. pmc Hominin life history: reconstruction and evolution
    Shannen L Robson
    Department of Anthropology, University of Utah, Salt Lake City, UT 84112, USA
    J Anat 212:394-425. 2008
    ..At least one extinct hominin subclade, Paranthropus, has a pattern of dental life history-related variables that most likely set it apart from the life histories of both modern humans and chimpanzees...
  78. ncbi 2.6-Million-year-old stone tools and associated bones from OGS-6 and OGS-7, Gona, Afar, Ethiopia
    Sileshi Semaw
    CRAFT Research Center, 419 N Indiana Avenue, Indiana University, Bloomington, IN 47405, USA
    J Hum Evol 45:169-77. 2003
  79. ncbi The derived FOXP2 variant of modern humans was shared with Neandertals
    Johannes Krause
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Curr Biol 17:1908-12. 2007
    ..Thus, these results illustrate the usefulness of retrieving direct genetic information from ancient remains for understanding recent human evolution...
  80. ncbi The revolution that wasn't: a new interpretation of the origin of modern human behavior
    S Mcbrearty
    Department of Anthropology, University of Connecticut, Storrs, Connecticut 06269, USA
    J Hum Evol 39:453-563. 2000
    ..If on anatomical and behavioral grounds H. helmei is sunk into H. sapiens, the origin of our species is linked with the appearance of Middle Stone Age technology at 250-300 ka...
  81. ncbi Origin of human bipedalism as an adaptation for locomotion on flexible branches
    S K S Thorpe
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Science 316:1328-31. 2007
    ..Human bipedalism is thus less an innovation than an exploitation of a locomotor behavior retained from the common great ape ancestor...
  82. ncbi Timing the origin of New World monkeys
    Carlos G Schrago
    Laboratorio Biodiversidade Molecular, Departamento de Genetica, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Brazil
    Mol Biol Evol 20:1620-5. 2003
    ..Our estimate for the origin of New World monkeys is in agreement with the hypothesis of a transatlantic journey from Africa to South America, as suggested by the fossil record...
  83. ncbi From the ape's dilemma to the weanling's dilemma: early weaning and its evolutionary context
    G E Kennedy
    Department of Anthropology, University of Calfornia, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90024, USA
    J Hum Evol 48:123-45. 2005
    ..The increased acquisition of meat ca. 2.6 Ma had significant effects on the later course of human evolution and may have initiated the origin of the genus Homo...
  84. ncbi The complete mitochondrial DNA genome of an unknown hominin from southern Siberia
    Johannes Krause
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nature 464:894-7. 2010
    ..The stratigraphy of the cave where the bone was found suggests that the Denisova hominin lived close in time and space with Neanderthals as well as with modern humans...
  85. ncbi Late Miocene hominids from the Middle Awash, Ethiopia
    Y Haile-Selassie
    Department of Integrative Biology, Museum of Vertebrate Zoology, University of California, Berkkeley 94720, USA
    Nature 412:178-81. 2001
    ..These new findings raise additional questions about the claimed hominid status of Orrorin tugenensis, recently described from Kenya and dated to approximately 6 Myr...
  86. pmc A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence
    H H Chou
    Glycobiology Program, Divisions of Hematology Oncology and Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 95:11751-6. 1998
    ..Also, the expression of Neu5Gc previously reported in human fetuses and tumors as well as the traces detected in some normal adult humans must be mediated by an alternate pathway...
  87. ncbi The first hominin of Europe
    Eudald Carbonell
    Institut Català de Paleoecologia humana i Evolució Social, Area de Prehistoria, Universitat Rovira i Virgili, Placa Imperial Tarraco 1, 43005 Tarragona, Spain
    Nature 452:465-9. 2008
    ....
  88. ncbi Catastrophic ape decline in western equatorial Africa
    Peter D Walsh
    Department of Ecology and Evolutionary Biology, Guyot Hall, Princeton, New Jersey 08540, USA
    Nature 422:611-4. 2003
    ..Without aggressive investments in law enforcement, protected area management and Ebola prevention, the next decade will see our closest relatives pushed to the brink of extinction...
  89. ncbi Late survival of Neanderthals at the southernmost extreme of Europe
    Clive Finlayson
    The Gibraltar Museum, 18 20 Bomb House Lane, Gibraltar
    Nature 443:850-3. 2006
    ..Our results show that the Neanderthals survived in isolated refuges well after the arrival of modern humans in Europe...
  90. doi Excavation protocol of bone remains for Neandertal DNA analysis in El Sidrón Cave (Asturias, Spain)
    Javier Fortea
    Area de Prehistoria, Departamento de Historia, Universidad de Oviedo, Oviedo, Spain
    J Hum Evol 55:353-7. 2008
  91. pmc The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae
    Daniel Kessler
    Department of Structural and Medicinal Biochemistry, Center for Medical Biotechnology ZMB, University of Duisburg Essen, 45117 Essen, Germany
    BMC Biol 5:37. 2007
    ..The recently identified parvulin Par17 contains an additional N-terminal domain whose occurrence and function was the focus of the present study...
  92. pmc Diet and the evolution of the earliest human ancestors
    M F Teaford
    Department of Cell Biology and Anatomy, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 97:13506-11. 2000
    ....
  93. ncbi On the phylogenetic position of the pre-Neandertal specimen from Reilingen, Germany
    D Dean
    Department of Neurological Surgery, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Hum Evol 34:485-508. 1998
    ..Biache 1), which present greater platycephaly, a reduced mastoid process, an enlarged juxtamastoid eminence, and true "en-bombe" (parieto-occipital form), and Weichsel Stage 4 "Neandertals" (sensu stricto, i.e., "classic" Neandertals)...
  94. pmc Locomotion and posture from the common hominoid ancestor to fully modern hominins, with special reference to the last common panin/hominin ancestor
    R H Crompton
    School of Biomedical Sciences, The University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, UK
    J Anat 212:501-43. 2008
    ..Derivation of habitual terrestrial bipedality from arboreal hand-assisted bipedality requires fewer transitions, and is also kinematically and kinetically more parsimonious...
  95. pmc Natural selection shaped regional mtDNA variation in humans
    Dan Mishmar
    Center for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, 92697 3940, USA
    Proc Natl Acad Sci U S A 100:171-6. 2003
    ..From these analyses we conclude that selection may have played a role in shaping human regional mtDNA variation and that one of the selective influences was climate...
  96. pmc Early Pleistocene 40Ar/39Ar ages for Bapang Formation hominins, Central Jawa, Indonesia
    R Larick
    URS Corporation, 100 California Street, Suite 500, San Francisco, CA 94111-4529, USA
    Proc Natl Acad Sci U S A 98:4866-71. 2001
    ..The chronological sequence of (40)Ar/(39)Ar ages follows stratigraphic order across the southeast quadrant. An intermediate level yielding four nearly complete crania has an age of about 1.25 Ma...
  97. ncbi The application of molecular genetic approaches to the study of human evolution
    L Luca Cavalli-Sforza
    Department of Genetics, Stanford Medical School, Stanford University, Stanford, California 94305 5120, USA
    Nat Genet 33:266-75. 2003
    ..The advances in our understanding of the evolutionary history of humans attests to the advantages of multidisciplinary research...
  98. ncbi Effects of brain and facial size on basicranial form in human and primate evolution
    Markus Bastir
    Paleoanthropology Group, Museo Nacional de Ciencias Naturales, CSIC, C J G Abascal, 2, Madrid, Spain
    J Hum Evol 58:424-31. 2010
    ..To better address the multifactorial nature of basicranial flexion, future studies should focus on the underlying factors influencing facial size evolution in hominins...
  99. ncbi Sphenoid shortening and the evolution of modern human cranial shape
    D E Lieberman
    Department of Anthropology, Rutgers University, New Brunswick, New Jersey 08903 0270, USA
    Nature 393:158-62. 1998
    ..sapiens...
  100. ncbi The evolution of human reproduction: a primatological perspective
    Robert D Martin
    Department of Anthropology, The Field Museum, Chicago, IL 60605 2496, USA
    Am J Phys Anthropol . 2007
    ..Nevertheless, the "natural" lactation period of humans is probably about 3 years, fitting the expectation in comparison to other hominoids...
  101. ncbi Pleistocene Homo sapiens from Middle Awash, Ethiopia
    Tim D White
    Department of Integrative Biology and Laboratory for Human Evolutionary Studies, Museum of Vertebrate Zoology, University of California, Berkeley, California 94720 3160, USA
    Nature 423:742-7. 2003
    ..They therefore represent the probable immediate ancestors of anatomically modern humans. Their anatomy and antiquity constitute strong evidence of modern-human emergence in Africa...

Research Grants56

  1. Inequality, social capital and health in Boliva
    William Leonard; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  2. Evolution of vertebrate sensory genes
    Jianzhi Zhang; Fiscal Year: 2010
    ..These studies will also help understand human smell and taste variations and disorders. ..
  3. NEURAL MECHANISMS OF SIZE PERCEPTION
    John Allman; Fiscal Year: 2001
    ..Finally, we will map the extent of the surrounding non-CRF by masking parts of the visual contextual display while measuring the responses to different sized stimuli presented within the CRF. ..
  4. Population structure in whole-genome disease scans
    David Reich; Fiscal Year: 2008
    ..We believe our new techniques will provide near-optimal power, and will be computationally efficient. We intend to make all these tools publicly available for the scientific community. [unreadable] [unreadable] [unreadable] [unreadable]..
  5. Simulation algorithms for genome-wide data and application to admixed data
    Jeffrey Wall; Fiscal Year: 2009
    ..This work will also help us determine the marker density and sample size needed for future association studies. ..
  6. Building a Latino admixture map & pilot study to find Type 2 Diabetes risk
    David Reich; Fiscal Year: 2007
    ..The study will also enable larger admixture mapping studies with many thousands of patients with Type 2 Diabetes, which we would like to pursue both in U.S. Latino and in Latin American populations. [unreadable] [unreadable] [unreadable]..
  7. RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in Autism
    Barbara J Wold; Fiscal Year: 2010
    ..We propose to use laser micro-dissection to investigate gene expression in specific neuronal and non-neuronal populations in the cortical areas of interest in the autism-A, autism-B and control groups. ..
  8. Associating genetic variation to resistance to severe malaria in East Africa
    David Reich; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  9. A Whole Genome Admixture Scan for Multiple Sclerosis
    David Reich; Fiscal Year: 2008
    ..We will then move to a targeted haplotype-based association study in the most interesting regions to clone new genes associated with MS. ..
  10. Evolution of BMP Genes 2 and 4 in Archosaurs
    CHRIS ORGAN; Fiscal Year: 2007
    ..Aim three is to elucidate the evolution of bmp2 and bmp4 coding regions. This project will be the first large scale examination of non-avian reptile genome structure and evolution. ..
  11. UW Genome Center Large-scale Sequencing Program
    Maynard Olson; Fiscal Year: 2006
    ..Other capabilities of the UWGC such as its automated finishing capacity will be made available to the NHGRI network on an as-needed basis. [unreadable] [unreadable] [unreadable]..
  12. ANALYSIS OF HUMAN CHROMOSOME 13Q NEOCENTROMERE FORMATION
    PETER WARBURTON; Fiscal Year: 2007
    ..Investigation of human centromere structure, function and formation will greatly facilitate the construction of artificial human chromosomes for use as autonomous gene expression vectors. ..
  13. Low dose digital X-rays for mammographic screening
    Christopher Vaughan; Fiscal Year: 2006
    ..During the last 6 months of the project in phase 2, we will conduct a limited clinical trial of 20 patients, focusing on comfort, breast coverage and diagnostic equivalence. ..
  14. E coli-based vectors for BAC delivery to mammalian cells
    PETER WARBURTON; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  15. Transcriptional and genic basis of incipient speciation
    Chung I Wu; Fiscal Year: 2008
    ..We expect to identify a number of candidate "speciation genes,* and will carry out precise gene replacement (Rong and Golic 2000; Greenberg et al. 2003) to confirm their effects on the mating behavior. ..
  16. The Genetic and Genomic Study of MicroRNA in Bipolar and Schizophrenia
    Richard A Gibbs; Fiscal Year: 2010
    ..These findings will potentially enhance our understanding of the miRNA genes and their potential roles in etiology of BD and SZ. Development of new diagnoses and treatments may result. ..
  17. 1/5: Elucidating the Genetic Architecture of Autism by Deep Genomic Sequencing
    Richard A Gibbs; Fiscal Year: 2010
    ....
  18. MicroRNA evolution and species divergence in Drosophila
    Chung I Wu; Fiscal Year: 2010
    ..A survey of the scope of microRNA repertoire and their rise and fall through evolution will be useful for understanding their roles in regulating the normal and aberrant phenotypes in human populations. ..
  19. Draft Sequence of the Rat Genome
    Richard Gibbs; Fiscal Year: 2002
    ..Finishing the rat sequence will be speeded by the development of a BAC minimum-tiling path across >95% of the genuine. ..
  20. Xenograft-like rejection of tumors in a-gal glycolipids
    URI GALILI GALILI; Fiscal Year: 2010
    ..We will study this treatment in a unique mouse model that simulates the pertinent human immunological parameters. Success in the studies in the mouse model will enable us to apply this treatment to cancer patients. ..
  21. Multiscale Analysis of Neuronal Morphology
    Patrick Hof; Fiscal Year: 2009
    ..Such studies will provide crucial insight into general mechanisms of memory induction and maintenance that underlie normal cognitive function, its dysfunction in diseased states, and potential mechanisms for its restoration. ..
  22. The repetitive DNA structure of the human genome
    PETER WARBURTON; Fiscal Year: 2009
    ..The studies proposed in this application will facilitate both computational and biological approaches to genomics and provide a unique analysis of a large and relatively neglected portion of our DNA sequence. ..
  23. Functions of Double-stranded RNA Binding Proteins
    Michael Mathews; Fiscal Year: 2008
    ..3. Protein complexes formed by NF90 isoforms and the changes brought about by viral infection, interferon treatment, and cell cycle block. 4. The functions of NF90 isoforms during infection with adenovirus and HIV. ..
  24. LYSOSOME BIOGENESIS IN NORMAL AND TUMOR CELLS
    Philip Stahl; Fiscal Year: 2006
    ..The goal of the present proposal is to set a solid foundation for future study by clarifying the role of Rin 1 in endocytic trafficking and signaling. ..
  25. REGULATION OF HIV1 GENE EXPRESSION BY TAT AND TAR
    Michael Mathews; Fiscal Year: 2001
    ..In addition, we propose to identify and study factor(s) responsible for potentiating Tat's ability to stimulate HIV-1 directed transcription in a cell-free system. ..
  26. LEARNING DISABILITIES IN ELEMENTARY MATHEMATICS
    DAVID GEARY; Fiscal Year: 2003
    ....
  27. MOLECULAR PHYLOGENY OF OLD WORLD MONKEY HOST SPECIES
    Caro Beth Stewart; Fiscal Year: 2003
    ..abstract_text> ..
  28. METHODS FOR SINGLE NUCLEOTIDE POLYMORPHISMS
    Maynard Olson; Fiscal Year: 2001
    ..We will evaluate a scoring technology (TDI) that has the potential to be arrayed. And we will develop software to facilitate the process of cSNP discovery, marker creation, and TDI scoring. ..
  29. PREVENTING ANTI-GAL PRODUCTION AGAINST XENOGRAFTS
    Uri Galili; Fiscal Year: 2003
    ..Success in these studies will help in planning effective treatments for preventing anti-Gal response in primate xenografts recipients. | ..
  30. SEQUENCING THE RAT GENOME
    Richard Gibbs; Fiscal Year: 2003
    ..The new sequence comparison methods will be appropriate for both finished and draft sequence studies. ..
  31. Integrated LC/MS/MS System
    Michael Mathews; Fiscal Year: 2002
    ..The addition of the integrated ThermoFinnigan LCQ DECA-10000/LC Packings Ultimate LC/MC/MS system will complement our existing MALDI-TOF instrument, permitting the facility to cover most of our mass spectrometry needs. ..
  32. E. COLI BASED VECTORS FOR GENE DELIVERY TO HUMAN CELLS
    PETER WARBURTON; Fiscal Year: 2002
    ..These studies propose to develop E. coli-based HAC vectors for human gene therapy that encompass novel approaches for gene delivery, accurate gene expression, and mitotic stability. ..
  33. Sequencing, assembly and annotation of a second Drosoph*
    Richard Gibbs; Fiscal Year: 2002
    ..pseudoobscura genes are fully represented. Two innovations for computer analysis of large sequence data sets will be explored. The per read cost for this work will be less than $1.80. ..
  34. EXPRESSION & FUNCTION OF MACROPHAGE MANNOSE RECEPTORS
    Philip Stahl; Fiscal Year: 2003
    ..The overall goal of this project is to identify the molecular components of the MR signaling pathway as a means of delineating the role of the MR, and other family members, in host defense and innate immunity. ..
  35. MECHANISMS OF ENZYMIC AND HYDRIDE TRANSFERS
    Gregory Petsko; Fiscal Year: 2006
    ..abstract_text> ..
  36. Mathematical Development in Learning Diasbled Children
    DAVID GEARY; Fiscal Year: 2003
    ..g., working memory) that underlie MD children's developmental delays and deficits in these competencies. ..
  37. INCREASE/gp120 IMMUNOGENICITY/LINKED ALPHA-GAL EPITOPES
    Uri Galili; Fiscal Year: 2005
    ..We will then also collaborate with a group studying immune responses in monkeys to determine the efficacy of this vaccine in a primate model. ..
  38. A 13q32 BAC Microarray for chromosome function analysis
    PETER WARBURTON; Fiscal Year: 2004
    ..The development of these types of high-density genomic microarrays will be a major step towards understanding the genomic organization and role of non-protein coding functional DNA elements in our cells. ..
  39. Mitochondrial-nuclear gene co-evolution and adaptation
    Caro Beth Stewart; Fiscal Year: 2005
    ..Furthermore, information about which proteins, or parts of proteins, have undergone recent positive selection may help define targets for intervention in certain human mitochondrial diseases. ..
  40. Sensory Transduction in the Vomeronasal System
    Emily Liman; Fiscal Year: 2005
    ....
  41. Center for the Study of Natural Genetic Variation
    Maynard Olson; Fiscal Year: 2005
    ..abstract_text> ..
  42. Sequencing the Chimpanzee Y Chromosome
    Jennifer Hughes; Fiscal Year: 2005
    ..However, because of several unique challenges posed by the Y chromosome, a dedicated effort will be required to obtain a complete and accurate sequence of this distinctive region of the chimpanzee genome. ..
  43. Gene Amplification and Deletion in Pancreatic Cancer
    Jonathan R Pollack; Fiscal Year: 2010
    ..abstract_text> ..
  44. Comparative Functional Genomics of Drosophila Obesity
    Andrew Clark; Fiscal Year: 2009
    ..which particular genes and pathways are most relevant to variation in fat storage homeostasis, and by developing a systems biology approach to make inferences from data that span cellular, endocrine, and whole-organism attributes ..
  45. Inferring Multiple-SNP Disease Association with DNA Resequence Data
    Rasmus Nielsen; Fiscal Year: 2010
    ..These methods will also be extended to include prior information about molecular mechanisms of gene function, where available, as well as environmental contributions to disease risk. ..
  46. Endothelial Cell in Progressive Renal Disease
    Richard Johnson; Fiscal Year: 2009
    ..abstract_text> ..
  47. TBC1D3: A HOMINOID-SPECIFIC GENE THAT REGULATES GROWTH FACTOR RECEPTOR SIGNALING
    Philip D Stahl; Fiscal Year: 2010
    ..TBC1D3 may serve as a model for developing an understanding of the function of human-specific genes in regulating complex signaling pathways. ..
  48. TRAINING IN COGNITIVE AND COMPUTATIONAL NEUROSCIENCE
    Michael Arbib; Fiscal Year: 2002
    ..The plan for the postdoctoral position focuses on permitting a student trained in psychology or linguistics to gain additional expertise related to cognitive and computational neuroscience. ..
  49. Three-Dimensional Dynamic Bone Histomorphometry
    CHRISTOPHER HERNANDEZ; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  50. LISTERIA MONOCYTOGENES AND PHAGOSOME MEMBRANE TRAFFIC
    Philip Stahl; Fiscal Year: 2003
    ..We will determine the effects of IFNgamma treatment on vesicular traffic into and out of LM phagosomes using GFP-Rab5, GFP-Rab7 and GFP-Rab11. ..
  51. Carcinogenesis: Effects of Diet Deficient in Methyl Donors
    Shi Huang; Fiscal Year: 2007
    ..The new understanding that will emerge from these studies will help clarify the role of nutrient metabolism in carcinogenesis. The results may have important public health implications. ..
  52. POLYMORPHISM/DIVERGENCE IN DROSOPHILA PATHOGEN DEFENSES
    Andrew Clark; Fiscal Year: 2002
    ....
  53. Dimension Reduction Approaches for Genome-wide Association Testing
    Andrew Clark; Fiscal Year: 2008
    ..Of particular interest will be the tuning model parameters to optimize the balance of false positive and false negative inferences. [unreadable] [unreadable] [unreadable] [unreadable]..
  54. GENETIC ARCHITECTURE OF THE HUMAN CRANIOFACIAL COMPLEX
    RICHARD SHERWOOD; Fiscal Year: 2008
    ..The proposed study of the genetic architecture of the craniofacial complex will provide information critical in characterizing the genetic underpinnings to normal craniofacial development and morphology. ..
  55. Genetic Architecture of the Baboon Craniofacial Complex
    RICHARD SHERWOOD; Fiscal Year: 2006
    ..unreadable] [unreadable]..