macaca mulatta

Summary

Summary: A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.

Top Publications

  1. ncbi Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 12:1365-71. 2006
  2. ncbi Neurophysiological investigation of the basis of the fMRI signal
    N K Logothetis
    Max Planck Institute for Biological Cybernetics, Tuebingen, Germany
    Nature 412:150-7. 2001
  3. pmc Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys
    Dan H Barouch
    Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 482:89-93. 2012
  4. ncbi Neural basis of a perceptual decision in the parietal cortex (area LIP) of the rhesus monkey
    M N Shadlen
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurophysiol 86:1916-36. 2001
  5. pmc Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
    Scott G Hansen
    Vaccine and Gene Therapy Institute, Department of Molecular Microbiology, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Nature 473:523-7. 2011
  6. ncbi Cortical control of a prosthetic arm for self-feeding
    Meel Velliste
    Department of Neurobiology, School of Medicine, E1440 BST, Lothrop Street, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Nature 453:1098-101. 2008
  7. ncbi Top-down versus bottom-up control of attention in the prefrontal and posterior parietal cortices
    Timothy J Buschman
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, and Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 315:1860-2. 2007
  8. pmc Sex-specific and lineage-specific alternative splicing in primates
    Ran Blekhman
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Genome Res 20:180-9. 2010
  9. ncbi Decorrelated neuronal firing in cortical microcircuits
    Alexander S Ecker
    Max Planck Institute for Biological Cybernetics, 72076 Tubingen, Germany
    Science 327:584-7. 2010
  10. pmc Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge
    Scott G Hansen
    Vaccine and Gene Therapy Institute, Department of Molecular Microbiology, and the Oregon National Primate Research Center, Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, USA
    Nat Med 15:293-9. 2009

Detail Information

Publications377 found, 100 shown here

  1. ncbi Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 12:1365-71. 2006
    ..These data establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection...
  2. ncbi Neurophysiological investigation of the basis of the fMRI signal
    N K Logothetis
    Max Planck Institute for Biological Cybernetics, Tuebingen, Germany
    Nature 412:150-7. 2001
    ..These findings suggest that the BOLD contrast mechanism reflects the input and intracortical processing of a given area rather than its spiking output...
  3. pmc Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys
    Dan H Barouch
    Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 482:89-93. 2012
    ..These data demonstrate the proof-of-concept that optimized HIV-1 vaccine candidates can block acquisition of stringent, heterologous, neutralization-resistant virus challenges in rhesus monkeys...
  4. ncbi Neural basis of a perceptual decision in the parietal cortex (area LIP) of the rhesus monkey
    M N Shadlen
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurophysiol 86:1916-36. 2001
    ..The time course of the neural response suggests that LIP accumulates sensory signals relevant to the selection of a target for an eye movement...
  5. pmc Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
    Scott G Hansen
    Vaccine and Gene Therapy Institute, Department of Molecular Microbiology, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Nature 473:523-7. 2011
    ..Thus, persistent vectors such as CMV and their associated T(EM) responses might significantly contribute to an efficacious HIV/AIDS vaccine...
  6. ncbi Cortical control of a prosthetic arm for self-feeding
    Meel Velliste
    Department of Neurobiology, School of Medicine, E1440 BST, Lothrop Street, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Nature 453:1098-101. 2008
    ..Here we describe a system that permits embodied prosthetic control; we show how monkeys (Macaca mulatta) use their motor cortical activity to control a mechanized arm replica in a self-feeding task...
  7. ncbi Top-down versus bottom-up control of attention in the prefrontal and posterior parietal cortices
    Timothy J Buschman
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, and Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 315:1860-2. 2007
    ..This result indicates that top-down and bottom-up signals arise from the frontal and sensory cortex, respectively, and different modes of attention may emphasize synchrony at different frequencies...
  8. pmc Sex-specific and lineage-specific alternative splicing in primates
    Ran Blekhman
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Genome Res 20:180-9. 2010
    ....
  9. ncbi Decorrelated neuronal firing in cortical microcircuits
    Alexander S Ecker
    Max Planck Institute for Biological Cybernetics, 72076 Tubingen, Germany
    Science 327:584-7. 2010
    ..Our findings suggest a refinement of current models of cortical microcircuit architecture and function: Either adjacent neurons share only a few percent of their inputs or, alternatively, their activity is actively decorrelated...
  10. pmc Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge
    Scott G Hansen
    Vaccine and Gene Therapy Institute, Department of Molecular Microbiology, and the Oregon National Primate Research Center, Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, USA
    Nat Med 15:293-9. 2009
    ..These data suggest a new paradigm for AIDS vaccine development--vaccines capable of generating and maintaining HIV-specific TEM cells might decrease the incidence of HIV acquisition after sexual exposure...
  11. pmc Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys
    Jinyan Liu
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 457:87-91. 2009
    ..virus (SIV) Gag failed to reduce peak or setpoint viral loads after SIV challenge of rhesus monkeys (Macaca mulatta) that lacked the protective MHC class I allele Mamu-A*01 (ref. 3)...
  12. ncbi The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys
    Matthew Stremlau
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 427:848-53. 2004
    ..Our studies identify TRIM5alpha as a species-specific mediator of innate cellular resistance to HIV-1 and reveal host cell components that modulate the uncoating of a retroviral capsid...
  13. ncbi Response of neurons in the lateral intraparietal area during a combined visual discrimination reaction time task
    Jamie D Roitman
    Program in Neurobiology and Behavior, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurosci 22:9475-89. 2002
    ..A threshold level of LIP activity appears to mark the completion of the decision process and to govern the tradeoff between accuracy and speed of perception...
  14. pmc Laminar differences in gamma and alpha coherence in the ventral stream
    Elizabeth A Buffalo
    Yerkes National Primate Research Center and Department of Neurology, Emory University School of Medicine, Atlanta, GA 30329, USA
    Proc Natl Acad Sci U S A 108:11262-7. 2011
    ..The results suggest that synchrony plays very different roles in feedback and feedforward projections...
  15. pmc Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies
    J R Mascola
    Division of Retrovirology, Walter Reed Army Institute of Research and Henry M Jackson Foundation, Rockville, Maryland 20850, USA
    J Virol 73:4009-18. 1999
    ..These data indicate a general correlation between in vitro neutralization and protection and suggest that a vaccine that elicits neutralizing antibody should have a protective effect against HIV-1 infection or disease...
  16. pmc Glycerol monolaurate prevents mucosal SIV transmission
    Qingsheng Li
    Department of Microbiology, Medical School, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis, Minnesota 55455, USA
    Nature 458:1034-8. 2009
    ....
  17. pmc High-frequency, long-range coupling between prefrontal and visual cortex during attention
    Georgia G Gregoriou
    McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 324:1207-10. 2009
    ....
  18. pmc Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response
    Beatrice Jacquelin
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France
    J Clin Invest 119:3544-55. 2009
    ..In conclusion, SIV infection triggered a rapid and strong IFN-alpha response in vivo in both AGMs and RMs, with this response being efficiently controlled only in AGMs, possibly as a result of active regulatory mechanisms...
  19. pmc Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers
    Ann J Hessell
    Department of Immunology and Microbial Science, and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA
    PLoS Pathog 5:e1000433. 2009
    ..The results raise the possibility that some epitopes on HIV may be better vaccine targets than others and support targeting the glycan shield of the envelope...
  20. pmc The primate amygdala represents the positive and negative value of visual stimuli during learning
    Joseph J Paton
    Center for Neurobiology and Behavior, Columbia University, 1051 Riverside Drive, Unit 87, New York, New York 10032, USA
    Nature 439:865-70. 2006
    ..Behavioural and physiological responses to visual stimuli may therefore be based in part on the plastic representation of value provided by the amygdala...
  21. ncbi Lateral habenula as a source of negative reward signals in dopamine neurons
    Masayuki Matsumoto
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    Nature 447:1111-5. 2007
    ..These results suggest that the inhibitory input from the lateral habenula plays an important role in determining the reward-related activity of dopamine neurons...
  22. ncbi Matching behavior and the representation of value in the parietal cortex
    Leo P Sugrue
    Howard Hughes Medical Institute and Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 304:1782-7. 2004
    ..We found that a simple model based on reward history can duplicate this behavior and that neurons in the parietal cortex represent the relative value of competing actions predicted by this model...
  23. pmc Stimulus onset quenches neural variability: a widespread cortical phenomenon
    Mark M Churchland
    Department of Electrical Engineering, Stanford University School of Medicine, Stanford University, Stanford, California, USA
    Nat Neurosci 13:369-78. 2010
    ..This widespread variability decline suggests a rather general property of cortex, that its state is stabilized by an input...
  24. pmc Different origins of gamma rhythm and high-gamma activity in macaque visual cortex
    Supratim Ray
    Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Biol 9:e1000610. 2011
    ..Further, they highlight the importance of making a careful dissociation between gamma rhythms and spike-related transients that could be incorrectly decomposed as rhythms using traditional signal processing methods...
  25. ncbi Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques
    Guangmei Yan
    The South China Center for Innovative Pharmaceuticals, Guangzhou, China
    Nat Biotechnol 29:1019-23. 2011
    ..However, we identify several putatively dysfunctional genetic differences between the three macaque species, which may explain functional differences between them previously observed in clinical studies...
  26. pmc Independent evolution of an antiviral TRIMCyp in rhesus macaques
    Sam J Wilson
    Medical Research Council Centre for Medical Molecular Virology, Department of Infection, Royal Free and University College Medical School, University College London, London W1T 4JF, United Kingdom
    Proc Natl Acad Sci U S A 105:3557-62. 2008
    ..Here, we show that the Old World monkey, rhesus macaque (Macaca mulatta), also encodes a TRIMCyp protein that has arisen independently from that in owl monkeys...
  27. pmc Spatio-temporal correlations and visual signalling in a complete neuronal population
    Jonathan W Pillow
    Gatsby Computational Neuroscience Unit, UCL, 17 Queen Square, London WC1N 3AR, UK
    Nature 454:995-9. 2008
    ..This model-based approach reveals the role of correlated activity in the retinal coding of visual stimuli, and provides a general framework for understanding the importance of correlated activity in populations of neurons...
  28. ncbi Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection
    Joseph J Mattapallil
    Immunotechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA
    Nature 434:1093-7. 2005
    ..Our findings point to the importance of reducing the cell-associated viral load during acute infection through therapeutic or vaccination strategies...
  29. pmc Attention improves performance primarily by reducing interneuronal correlations
    Marlene R Cohen
    Howard Hughes Medical Institute and Harvard Medical School Department of Neurobiology, Boston, Massachusetts, USA
    Nat Neurosci 12:1594-600. 2009
    ..These results suggest that the representation of sensory information in populations of neurons and the way attention affects the sensitivity of the population may only be understood by considering the interactions between neurons...
  30. pmc Transcriptional neoteny in the human brain
    Mehmet Somel
    Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Proc Natl Acad Sci U S A 106:5743-8. 2009
    ..This delay is not uniform across the human transcriptome but affects a specific subset of genes that play a potential role in neural development...
  31. pmc A cortical region consisting entirely of face-selective cells
    Doris Y Tsao
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Science 311:670-4. 2006
    ..Almost all (97%) of the visually responsive neurons in this region were strongly face selective, indicating that a dedicated cortical area exists to support face processing in the macaque...
  32. ncbi Medial prefrontal cell activity signaling prediction errors of action values
    Madoka Matsumoto
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Nat Neurosci 10:647-56. 2007
    ..Therefore, these responses in medial prefrontal cells may signal the direction and amount of error in prediction of values of executed actions to specify the adjustment in subsequent action selections...
  33. pmc A B-box 2 surface patch important for TRIM5alpha self-association, capsid binding avidity, and retrovirus restriction
    Felipe Diaz-Griffero
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Virol 83:10737-51. 2009
    ..Thus, promoting cooperative TRIM5alpha(rh) interactions with the HIV-1 capsid represents a major mechanism whereby the B-box 2 domain potentiates HIV-1 restriction...
  34. pmc Decoding complete reach and grasp actions from local primary motor cortex populations
    Carlos E Vargas-Irwin
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 30:9659-69. 2010
    ..techniques with full arm motion capture to relate neural activity in primary motor cortex (M1) of macaques (Macaca mulatta) to arm, wrist, and hand postures during movement...
  35. pmc Prevention of infection by a granulocyte-macrophage colony-stimulating factor co-expressing DNA/modified vaccinia Ankara simian immunodeficiency virus vaccine
    Lilin Lai
    Yerkes National Primate Research Center, USA
    J Infect Dis 204:164-73. 2011
    ..The prevention of infection showed a strong correlation with the avidity of the elicited Env-specific antibody for the Env of the SIVsmE660 challenge virus (r = 0.9; P < .0001)...
  36. pmc An anti-HIV-1 V3 loop antibody fully protects cross-clade and elicits T-cell immunity in macaques mucosally challenged with an R5 clade C SHIV
    Jennifer D Watkins
    Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
    PLoS ONE 6:e18207. 2011
    ....
  37. pmc Neural substrates of cognitive capacity limitations
    Timothy J Buschman
    The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 108:11252-5. 2011
    ..Together, these results suggest visual capacity limitation is due to discrete, slot-like, resources, each containing limited pools of neural information that can be divided among objects...
  38. pmc Novel escape mutants suggest an extensive TRIM5α binding site spanning the entire outer surface of the murine leukemia virus capsid protein
    Sadayuki Ohkura
    Division of Virology, MRC National Institute for Medical Research, London, United Kingdom
    PLoS Pathog 7:e1002011. 2011
    ..We conclude that interactions involving much, if not all, of the surface of CA are vital for TRIM5α binding...
  39. ncbi Adaptive coding of visual information in neural populations
    Diego A Gutnisky
    Department of Neurobiology and Anatomy, University of Texas Houston Medical School, Houston, Texas 77030, USA
    Nature 452:220-4. 2008
    ..influences the structure of interneuronal correlations and the accuracy of population coding in the macaque (Macaca mulatta) primary visual cortex (V1)...
  40. ncbi Connections underlying the synthesis of cognition, memory, and emotion in primate prefrontal cortices
    H Barbas
    Department of Health Sciences, Boston University and Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02215, USA
    Brain Res Bull 52:319-30. 2000
    ....
  41. ncbi Practising orientation identification improves orientation coding in V1 neurons
    A Schoups
    Laboratorium voor Neuro en Psychofysiologie, K U Leuven Medical School, B 3000 Leuven, Belgium
    Nature 412:549-53. 2001
    ..No modifications of the tuning curve were observed for orientations for which the monkey had not been trained. Thus training induces a specific and efficient increase in neuronal sensitivity in V1...
  42. pmc Large identified pyramidal cells in macaque motor and premotor cortex exhibit "thin spikes": implications for cell type classification
    Ganesh Vigneswaran
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 31:14235-42. 2011
    ..In summary, one class of physiologically identified cortical pyramidal neuron exhibits a wide variety of spike durations and the results suggest that spike duration alone may not be a reliable indicator of cell type...
  43. ncbi Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    J H Kordower
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Science 290:767-73. 2000
    ..These data indicate that GDNF delivery using a lentiviral vector system can prevent nigrostriatal degeneration and induce regeneration in primate models of PD and might be a viable therapeutic strategy for PD patients...
  44. pmc Control of visual cortical signals by prefrontal dopamine
    Behrad Noudoost
    Howard Hughes Medical Institute and Department of Neurobiology, Stanford University School of Medicine, Fairchild Building, 299 Campus Drive West, Stanford, California 94305, USA
    Nature 474:372-5. 2011
    ..we show that dopamine D1 receptors mediate prefrontal control of signals in the visual cortex of macaques (Macaca mulatta)...
  45. pmc Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections
    Ming Zeng
    Department of Microbiology, Medical School, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Clin Invest 121:998-1008. 2011
    ..Because this process is cumulative, early treatment and antifibrotic therapies may offer approaches to moderate T cell depletion and improve immune reconstitution during HIV-1 infection...
  46. pmc Enhanced control of pathogenic Simian immunodeficiency virus SIVmac239 replication in macaques immunized with an interleukin-12 plasmid and a DNA prime-viral vector boost vaccine regimen
    Nicola Winstone
    International AIDS Vaccine Initiative, Design and Development Laboratory, Brooklyn Army Terminal, 140 58th Street, Brooklyn, NY 11220, USA
    J Virol 85:9578-87. 2011
    ..This vaccine strategy is relevant for existing vaccine candidates entering clinical evaluation, and this model may provide insights into control of retrovirus replication...
  47. pmc Major histocompatibility complex genotyping with massively parallel pyrosequencing
    Roger W Wiseman
    Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, Wisconsin, USA
    Nat Med 15:1322-6. 2009
    ..The remarkable sensitivity of this approach in macaques demonstrates that pyrosequencing is viable for ultra-high-throughput MHC genotyping of primates, including humans...
  48. pmc Reward-dependent modulation of neuronal activity in the primate dorsal raphe nucleus
    Kae Nakamura
    Laboratory of Sensorimotor Research, National Eye Institute National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    J Neurosci 28:5331-43. 2008
    ..These results suggest that the DRN, probably including serotonin neurons, signals the reward value associated with the current behavior...
  49. ncbi Intrinsic functional architecture in the anaesthetized monkey brain
    J L Vincent
    Department of Radiology, Washington University in St Louis, Missouri 63110, USA
    Nature 447:83-6. 2007
    ..Our results indicate that coherent system fluctuations probably reflect an evolutionarily conserved aspect of brain functional organization that transcends levels of consciousness...
  50. pmc A central source of movement variability
    Mark M Churchland
    Neurosciences Program, Stanford University, Stanford, California 94305, USA
    Neuron 52:1085-96. 2006
    ..Thus, even for a highly practiced task, the ability to repeatedly plan the same movement limits our ability to repeatedly execute the same movement...
  51. pmc Active site remodeling switches HIV specificity of antiretroviral TRIMCyp
    Amanda J Price
    Protein and Nucleic Acid Chemistry Division, Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    Nat Struct Mol Biol 16:1036-42. 2009
    ..Our results reveal the complex molecular, structural and thermodynamic changes that underlie the ongoing evolutionary race between virus and host...
  52. ncbi Neural correlates of reaching decisions in dorsal premotor cortex: specification of multiple direction choices and final selection of action
    Paul Cisek
    Departement de Physiologie, Universite de Montreal, Montreal Quebec H3C 3J7, Canada
    Neuron 45:801-14. 2005
    ..This supports a planning model in which multiple reach options are initially specified and then gradually eliminated in a competition for overt execution, as more information accumulates...
  53. pmc Millisecond-timescale optical control of neural dynamics in the nonhuman primate brain
    Xue Han
    Media Lab, Synthetic Neurobiology Group, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Neuron 62:191-8. 2009
    ....
  54. pmc Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection
    Afam Okoye
    Vaccine and Gene Therapy Institute, Department of Pathology, and the Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Exp Med 204:2171-85. 2007
    ....
  55. pmc The Toll-like receptor 7 (TLR7) agonist, imiquimod, and the TLR9 agonist, CpG ODN, induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaques
    Yichuan Wang
    California National Primate Research Center, University of California Davis, Davis, California 95616, USA
    J Virol 79:14355-70. 2005
    ..We conclude that induction of mucosal innate immunity including an IFN-alpha response is not sufficient to prevent sexual transmission of human immunodeficiency virus...
  56. pmc Similarity of bisphenol A pharmacokinetics in rhesus monkeys and mice: relevance for human exposure
    Julia A Taylor
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Environ Health Perspect 119:422-30. 2011
    ..We measured unconjugated and conjugated BPA levels in serum from adult female rhesus monkeys and adult female mice after oral administration of BPA and compared findings in mice and monkeys with prior published data in women...
  57. pmc Guarding the gateway to cortex with attention in visual thalamus
    Kerry McAlonan
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 456:391-4. 2008
    ..Here we show, by recording neurons in attending macaque monkeys (Macaca mulatta), that attention modulates visual signals before they even reach cortex by increasing responses of both ..
  58. ncbi Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
    A A Young
    Amylin Pharmaceuticals, San Diego, California 92121, USA
    Diabetes 48:1026-34. 1999
    ..0 microg/kg+/-0.15 log and 2.4 microg/kg+/-0.41 log, respectively. In conclusion, acute and chronic administration of exendin-4 has demonstrated an antidiabetic effect in several animal models of type 2 diabetes...
  59. pmc Distinct representations of a perceptual decision and the associated oculomotor plan in the monkey lateral intraparietal area
    Sharath Bennur
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6074, USA
    J Neurosci 31:913-21. 2011
    ..The results suggest that perceptual decision-making and action selection are different brain processes that only appear to be inseparable under particular behavioral contexts...
  60. pmc Free choice activates a decision circuit between frontal and parietal cortex
    Bijan Pesaran
    Center for Neural Science, New York University, New York, New York 10003, USA
    Nature 453:406-9. 2008
    ..Cells participating in this decision circuit may influence movement choices by providing a common bias to the selection of movement goals...
  61. pmc Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques
    Alexandra M Ortiz
    Yerkes National Primate Research Center and Emory Vaccine Center, Emory University, Atlanta, Georgia, USA
    J Clin Invest 121:4433-45. 2011
    ..Our results suggest that the antiviral CD4+ T cell response may play an important role in limiting SIV replication, which has implications for the design of HIV vaccines...
  62. ncbi Anti-retroviral activity of TRIM5 alpha
    Emi E Nakayama
    Department of Viral Infections, Research Institute for Microbial Disease, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Rev Med Virol 20:77-92. 2010
    ..Accurate structural analysis of the binding surface between the viral capsid protein and TRIM5 alpha SPRY is thus required for the development of new antiretroviral drugs that enhance anti-HIV-1 activity of human TRIM5 alpha...
  63. ncbi Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
    J E Schmitz
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 283:857-60. 1999
    ..These results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses...
  64. ncbi The structure of multi-neuron firing patterns in primate retina
    Jonathon Shlens
    Department of Systems Neurobiology, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 26:8254-66. 2006
    ..This approach provides a way to define limits on the complexity of network interactions and thus may be relevant for probing the function of many neural circuits...
  65. pmc Mamu-B*08-positive macaques control simian immunodeficiency virus replication
    John T Loffredo
    Wisconsin National Primate Research Center, University of Wisconsin Madison, 555 Science Drive, Madison, WI 53711, USA
    J Virol 81:8827-32. 2007
    ..002). Mamu-B*08-positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers...
  66. pmc Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1
    Brandon F Keele
    University of Alabama at Birmingham, Birmingham, AL 35223, USA
    J Exp Med 206:1117-34. 2009
    ..These findings identify key similarities in mucosal transmission and early diversification between SIV and HIV-1, and thus validate the SIV-macaque mucosal infection model for HIV-1 vaccine and microbicide research...
  67. ncbi Comparative cytoarchitectonic analysis of the human and the macaque ventrolateral prefrontal cortex and corticocortical connection patterns in the monkey
    M Petrides
    Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, H3A B4 Canada
    Eur J Neurosci 16:291-310. 2002
    ..e. the auditory association cortex) and the multimodal cortex in the upper bank of the superior temporal sulcus...
  68. pmc Enhancing SIV-specific immunity in vivo by PD-1 blockade
    Vijayakumar Velu
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 458:206-10. 2009
    ....
  69. pmc Periodicity and evoked responses in motor cortex
    Jacob Reimer
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 30:11506-15. 2010
    ..We simultaneously recorded multiple single units and local field potentials in MI in two monkeys (Macaca mulatta) during continuous, self-paced movements to serially presented targets...
  70. pmc Roles of monkey premotor neuron classes in movement preparation and execution
    Matthew T Kaufman
    Neurosciences Program, Stanford University, Stanford, California 94305 4075, USA
    J Neurophysiol 104:799-810. 2010
    ....
  71. pmc Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44+ mucosal NK cells during SIV infection
    R Keith Reeves
    Divisions of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, MA, USA
    Blood 118:3321-30. 2011
    ..Thus lentiviral infection both depletes and modifies the functional repertoire of mucosal NK cells involved in the maintenance of gut integrity, a finding that highlights the plasticity of this rare mucosal NK-cell population...
  72. pmc Reward value-based gain control: divisive normalization in parietal cortex
    KENWAY LOUIE
    Center for Neural Science and Center for Neuroeconomics, New York University, New York, New York 10003, USA
    J Neurosci 31:10627-39. 2011
    ..Such normalization in decision circuits effectively implements an adaptive gain control for value coding and provides a possible mechanistic basis for behavioral context-dependent violations of rationality...
  73. pmc Spatial alterations between CD4(+) T follicular helper, B, and CD8(+) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral escape
    Jung Joo Hong
    Division of Pathology, Yerkes National Primate Research Center, Atlanta, GA 30329, USA
    J Immunol 188:3247-56. 2012
    ....
  74. ncbi A representation of the hazard rate of elapsed time in macaque area LIP
    Peter Janssen
    Howard Hughes Medical Institute, National Primate Research Center and Department of Physiology and Biophysics, University of Washington, Box 357290, Seattle, Washington 98195, USA
    Nat Neurosci 8:234-41. 2005
    ..The results indicate that the parietal cortex contains circuitry for representing the time structure of environmental cues over a range of seconds...
  75. pmc Infection with "escaped" virus variants impairs control of simian immunodeficiency virus SIVmac239 replication in Mamu-B*08-positive macaques
    Laura E Valentine
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Virol 83:11514-27. 2009
    ..04). Our results suggest that these epitope-specific CD8+ T-cell responses may play a role in establishing the control of viral replication in Mamu-B*08+ macaques...
  76. ncbi Functional heterogeneity of macaque lateral intraparietal neurons
    Elsie Premereur
    Laboratorium voor Neuro en Psychofysiologie, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    J Neurosci 31:12307-17. 2011
    ..Our results suggest that between-study differences in neuronal selection may have contributed significantly to the findings of different research groups with respect to the functional role of area LIP...
  77. pmc The role of temporal cortical areas in perceptual organization
    D L Sheinberg
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 94:3408-13. 1997
    ....
  78. pmc Encoding of reward and space during a working memory task in the orbitofrontal cortex and anterior cingulate sulcus
    Steven W Kennerley
    Department of Psychology, University of California, Berkeley, CA 94720 3190, USA
    J Neurophysiol 102:3352-64. 2009
    ..They also suggest that neither PFo nor PFcs play a direct role in the control of spatial attention...
  79. pmc Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection
    Qingsheng Li
    Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    Science 323:1726-9. 2009
    ..This method highlights the importance of the location, timing, and magnitude of the immune response needed for a vaccine to be effective against agents of persistent infection, such as HIV-1...
  80. ncbi Interferon-induced expression of MxA in the respiratory tract of rhesus macaques is suppressed by influenza virus replication
    Timothy D Carroll
    California National Primate Research Center, and Center for Comparative Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    J Immunol 180:2385-95. 2008
    ..These results demonstrate for the first time that uncontrolled influenza A virus replication actively suppresses MxA gene expression and emphasize the critical role of innate immunity in controlling influenza virus replication in vivo...
  81. ncbi Development and homeostasis of T cell memory in rhesus macaque
    Christine J Pitcher
    Vaccine and Gene Therapy Institute, Oregon Regional Primate Research Center, Oregon Health and Science University, West Campus, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    J Immunol 168:29-43. 2002
    ..The effector memory subset demonstrated similar in vivo proliferative activity and survival as CD28+ "central memory" T cells, consistent with independent homeostatic regulation...
  82. pmc Evaluating choices by single neurons in the frontal lobe: outcome value encoded across multiple decision variables
    Steven W Kennerley
    Helen Wills Neuroscience Institute and Department of Psychology, University of California at Berkeley, 132 Barker Hall MC 3190, Berkeley, CA 94720 3190, USA
    Eur J Neurosci 29:2061-73. 2009
    ..These results support a role for the frontal cortex, principally ACC, in selecting between choice alternatives and evaluating the outcome of that selection thereby ensuring that choices are optimal and adaptive...
  83. ncbi Early restoration of mucosal CD4 memory CCR5 T cells in the gut of SIV-infected rhesus predicts long term non-progression
    Binhua Ling
    Tulane National Primate Research Center, Covington, Louisianna, USA
    AIDS 21:2377-85. 2007
    ..The key questions addressed were whether or not LTNP experience an early and rapid loss of mucosal CD4 T cells during the acute infection and the mechanisms by which they maintain the LTNP state...
  84. pmc Rhesus TRIM5α disrupts the HIV-1 capsid at the inter-hexamer interfaces
    Gongpu Zhao
    Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS Pathog 7:e1002009. 2011
    ....
  85. pmc Moment-to-moment tracking of state value in the amygdala
    Marina A Belova
    Department of Neuroscience, Columbia University Medical Center, New York, New York 10032, USA
    J Neurosci 28:10023-30. 2008
    ..This representation of state value could underlie how the amygdala helps coordinate cognitive, emotional, and behavioral responses depending on the value of one's state...
  86. pmc Distinct encoding of spatial and nonspatial visual information in parietal cortex
    David J Freedman
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 29:5671-80. 2009
    ....
  87. pmc Spontaneous number representation in semi-free-ranging rhesus monkeys
    M D Hauser
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Proc Biol Sci 267:829-33. 2000
    ..The range of success achieved by rhesus monkeys in this spontaneous-number task matches the range achieved by human infants and corresponds to the range encoded in the syntax of natural languages...
  88. ncbi A high-performance brain-computer interface
    Gopal Santhanam
    Department of Electrical Engineering, Stanford University, 330 Serra Mall, 319 Paul G Allen Center for Integrated Systems Annex, Stanford, California 94305 4075, USA
    Nature 442:195-8. 2006
    ..These performance results and their implications for system design should substantially increase the clinical viability of BCIs in humans...
  89. pmc Estimates of the contribution of single neurons to perception depend on timescale and noise correlation
    Marlene R Cohen
    Howard Hughes Medical Institute and Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 29:6635-48. 2009
    ..These new data, considered together with our recent data on noise correlation in MT (Cohen and Newsome, 2008), provide a substantially improved account of psychometric performance in the direction-discrimination task...
  90. pmc Multiple sites in the N-terminal half of simian immunodeficiency virus capsid protein contribute to evasion from rhesus monkey TRIM5α-mediated restriction
    Ken Kono
    Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Retrovirology 7:72. 2010
    ..In contrast, rhesus monkey (Rh) TRIM5α could restrict all HIV-2 strains tested but not simian immunodeficiency virus isolated from macaque (SIVmac), despite its genetic similarity to HIV-2...
  91. pmc Subdominant CD8+ T-cell responses are involved in durable control of AIDS virus replication
    Thomas C Friedrich
    Wisconsin National Primate Research Center, 1220 Capitol Court, Madison, WI 53715 1299, USA
    J Virol 81:3465-76. 2007
    ..It is likely that subdominant CD8+ T-cell populations play a key role in maintaining this control...
  92. pmc CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells
    Nichole R Klatt
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 6:e1000747. 2010
    ....
  93. pmc In vivo CD8+ T-cell suppression of siv viremia is not mediated by CTL clearance of productively infected cells
    Joseph K Wong
    Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 6:e1000748. 2010
    ..These observations have important implications for future strategies to augment immune control of HIV...
  94. ncbi Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity
    John W Shiver
    Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Nature 415:331-5. 2002
    ..The replication-defective adenovirus is a promising vaccine vector for development of an HIV-1 vaccine...
  95. pmc Molecularly cloned SHIV-1157ipd3N4: a highly replication- competent, mucosally transmissible R5 simian-human immunodeficiency virus encoding HIV clade C Env
    R J Song
    Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Virol 80:8729-38. 2006
    ..We conclude that SHIV-1157ipd3N4 is a highly replication-competent, mucosally transmissible R5 SHIV that represents a valuable tool to test candidate AIDS vaccines targeting HIV-1 clade C Env...
  96. ncbi Single neurons in prefrontal cortex encode abstract rules
    J D Wallis
    Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 411:953-6. 2001
    ..The most prevalent neuronal activity observed in the PFC reflected the coding of these abstract rules...
  97. pmc Roles of target cells and virus-specific cellular immunity in primary simian immunodeficiency virus infection
    Roland R Regoes
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    J Virol 78:4866-75. 2004
    ..Our results show that early viral replication in normal infection is controlled to a large extent by virus-specific CD8(+) T cells and not by target cell limitation...
  98. ncbi Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification
    Asli N Silahtaroglu
    Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Nat Protoc 2:2520-8. 2007
    ....
  99. ncbi Experience-dependent representation of visual categories in parietal cortex
    David J Freedman
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 443:85-8. 2006
    ..This indicates that LIP might be an important nexus for the transformation of visual direction selectivity to more abstract representations that encode the behavioural relevance, or meaning, of stimuli...
  100. ncbi An oscillatory hierarchy controlling neuronal excitability and stimulus processing in the auditory cortex
    Peter Lakatos
    Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Inst, Orangeburg, New York 10962, USA
    J Neurophysiol 94:1904-11. 2005
    ..We propose that the hierarchical organization of ambient oscillatory activity allows auditory cortex to structure its temporal activity pattern so as to optimize the processing of rhythmic inputs...
  101. ncbi Probabilistic reasoning by neurons
    Tianming Yang
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, National Primate Research Center, University of Washington, Box 357290, Seattle, Washington 98195 7290, USA
    Nature 447:1075-80. 2007
    ..Monkeys learned to combine probabilistic information from the shape combinations. Moreover, neurons in the parietal cortex reveal the addition and subtraction of probabilistic quantities that underlie decision-making on this task...

Research Grants73

  1. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  2. RNA interference therapy for Huntington's disease: studies in non-human primates
    Beverly L Davidson; Fiscal Year: 2010
    ..This work is a collaborative effort between laboratories at the University of Iowa and the Oregon National Primate Research Center at the Oregon Health Sciences University. ..
  3. Interacting Impact of Adrenal and Ovarian Aging on the CNS
    Henryk F Urbanski; Fiscal Year: 2011
    ..By elucidating the interacting impact of declining ovarian and adrenal steroids on CNS function, we expect to lay a foundation for the development of therapies for many aging-associated disorders in women. ..
  4. Genomics of RNA Editing: Identification and Regulation
    Jin Billy Li; Fiscal Year: 2013
    ....
  5. Neuroendocrine Response to Gastric Bypass in Nonhuman Primates
    Randy J Seeley; Fiscal Year: 2010
    ....
  6. Leukemia Inhibitory Factor As a Mediator of Primate Ovulation &Oocyte Maturation
    Jon D Hennebold; Fiscal Year: 2013
    ..e., pre-hCG) will be directly exposed to LIF to determine a direct effect of this cytokine on promoting C-OE, reinitiation of meiosis, fertilization, and embryonic development. ..
  7. Physiology and structure of prefrontal projections to memory and motor circuits
    Maria Medalla; Fiscal Year: 2013
    ..and intracellular filling of retrogradely-labeled neurons in slices prepared from adult rhesus monkeys (Macaca mulatta)...
  8. Simianizing hepatitis C: Defining the species-tropism of a hepatotropic virus
    Charles M Rice; Fiscal Year: 2013
    ..As a host species, we will initially focus on Rhesus macaques (Macaca mulatta) - monkeys that can be bred in captivity, have sufficient available research tools, are readily obtainable, ..
  9. A Novel Oral Combination Pediatric HIV and TB Vaccine
    Michelle H Larsen; Fiscal Year: 2012
    ....
  10. Cognition in Rhesus Macaques in Relation to Age and Endocrine Status
    Henryk F Urbanski; Fiscal Year: 2013
    ..Consequently, data from the ongoing female study, combined with data from the proposed male study, will disclose important gender-based differences and help to elucidate their underlying mechanisms. ..
  11. Development of a novel vaccine for protection against gammaherpesvirus infection
    Blossom A Damania; Fiscal Year: 2010
    ..Thus, this collaborative project integrates the PI's expertise in KSHV and RRV, with Dr. Desrosiers'expertise in vaccine design and development, and the use of primate infection models for RRV. ..
  12. Dorsal Column Stimulation as a New Therapy for Motor Disorders
    Miguel A L Nicolelis; Fiscal Year: 2013
    ..aim is to evaluate DCS in two nonhuman primate species, owl monkeys (Aotus trivirgatus) and rhesus macaques (Macaca mulatta), treated with 6-hydroxydopamine...
  13. Novel Vaginal Microbicides Based On Stable AAV-Neutralizing Antibody Gene Transfe
    Wayne A Marasco; Fiscal Year: 2010
    ..A protective genetic microbicide delivered to the female lower genital track could dramatically slow the spread of HIV/AIDS. ..
  14. Complete genomic DNA sequence of the sooty mangabey MHC
    Daniel E Geraghty; Fiscal Year: 2012
    ..This resource will contribute to identifying causative host genetic factors controlling HIV-1 infection in humans, providing direction for disease treatment as well as for vaccine design. ..
  15. FOXP2-Regulated Signaling Pathways Critical for Higher Cognitive Functions
    Genevieve Konopka; Fiscal Year: 2010
    ..These proposed studies will provide insight into the developmental mechanisms underlying cognition and how they are disrupted in mental illness. ..
  16. Mechanism and Therapy of HIV Encephalitis
    Shilpa J Buch; Fiscal Year: 2012
    ....
  17. Methamphetamine and Immune Cells in NeuroAIDS
    Maria Cecilia Garibaldi Marcondes; Fiscal Year: 2012
    ..These studies will help understand mechanisms regulating the severity of brain and other tissues pathology in HIV+ Meth users and reveal direct Meth targets on innate immune cells. ..
  18. Visual Processing and Smooth Eye Movements
    Michael J Mustari; Fiscal Year: 2012
    ..animal models for studying the development of the visual and oculomotor systems by raising infant monkeys (Macaca mulatta) with either surgical or prism induced strabismus...
  19. Viral evolution in peropheral macrophages and brain during progression to AIDS
    Marco Salemi; Fiscal Year: 2013
    ..The result will be a description of the genetic basis for the onset of dementia in patients with AIDS leading the way to the development of new diagnostic and therapeutic tools. ..
  20. Large-Scale Discovery of Functional Genetic Variation in Rhesus Macaques
    JEFFREY A ROGERS; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Rhesus macaques (Macaca mulatta) are the most widely used nonhuman primate in biomedical research...
  21. The Immunogenetics of Macaques Used in Biodefense Research
    ALESSANDRO D SETTE; Fiscal Year: 2011
    Rhesus macaques (Macaca mulatta) and Cynomolgus macaques (Macaca fascicularis), are widely used as models of disease pathogenesis in humans and for evaluating vaccines and therapeutics against microbial pathogens, including emerging ..
  22. Multivalent Plague, Anthrax Vaccines Using Bacteriophage T4 Display
    Venigalla B Rao; Fiscal Year: 2013
    ..The efficacy of this vaccine for protection against both inhalation anthrax and pneumonic plague will be tested in rhesus macaque aerosol challenge in model. ..
  23. Identifying enhancers with human-specific developmental functions
    James P Noonan; Fiscal Year: 2013
    ..Our research may thus shed light on the genetic and evolutionary basis of diseases that are unique to our species. ..
  24. Evaluation of stem cell-derived retinal pigment epithelial cells for retinal dise
    MARTHA D NEURINGER; Fiscal Year: 2013
    ..These findings will be key to the safe translation of this therapy into clinic for the treatment of such conditions as age-related macular degeneration. ..
  25. Large-Scale Discovery of Functional Genetic Variation in Rhesus Macaques
    JEFFREY A ROGERS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Rhesus macaques (Macaca mulatta) are the most widely used nonhuman primate in biomedical research...
  26. The Impact of Tolerance in the Newborn on Lentiviral Infection
    Joseph M McCune; Fiscal Year: 2013
    ..tuberculosis and malaria) that often co-exist with HIV as well as against other illnesses (e.g., autoimmune diseases) or conditions (e.g., organ transplantation) in which the induction of antigen-specific tolerance might be beneficial. ..
  27. Development of a Live Combinational Microbicide for Women
    Qiang Xu; Fiscal Year: 2010
    ..We will employ a Chinese rhesus macaque (Macaca mulatta) model that allows persistent vaginal colonization of L...
  28. Neurodegeneration in Aged SIV-Infected Primates
    Clayton A Wiley; Fiscal Year: 2013
    ..to use a well-established non-human primate (NHP) model of chronic lentiviral infection, SIV infection of Macaca mulatta (Rhesus Macaque RM), to model HAND in aged macaques (>20 years old), map the neurological signs to ..
  29. STUDIES OF ALPHA-DEFENSINS IN PRIMATE INNATE IMMUNITY
    Andre J Ouellette; Fiscal Year: 2010
    ..of this research is to investigate the role of alpha-defensins in innate immunity of the rhesus macaque (Macaca mulatta)...
  30. Defensin gene copy number and mucosal innate immunity
    JAY V contact SOLNICK; Fiscal Year: 2010
    ..We hypothesize that differences in BD2 GCN affect the host inflammatory response, and thus the propensity to develop disease after infection with H. pylori. ..
  31. A Novel Monkey Model for Parkinson's Drug Discovery
    Howard J Federoff; Fiscal Year: 2010
    ..This model will also be used to test novel therapeutic small molecule LRRK2 inhibitors. ..
  32. SIV-specific Mamu-E-restricted CD8+ T cells
    David I Watkins; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Finding a vaccine for HIV is probably one of the most important goals of biomedical research. We will use approaches derived from cancer research to try to find new targets for an HIV vaccine. ! ..
  33. Genetic and Epigenetic Analysis of Alcohol Self-Administration in Monkeys
    Betsy M Ferguson; Fiscal Year: 2013
    ....
  34. Monocyte-Macrophage Dynamics in NeuroAIDS
    Jay Rappaport; Fiscal Year: 2013
    ....
  35. ESTABLISHMENT OF A SPF RHESUS MACAQUE COLONY
    LARRY BILL CUMMINS; Fiscal Year: 2011
    ..of this project are to increase the nation's capacity to produce pedigreed specific pathogen free (SPF) Macaca mulatta for AIDS-related research by maintaining a production colony of Indian-origin rhesus monkeys that are SPF for ..
  36. Efficacy of a Novel Neuroprotective Compound in Nonhuman Primate
    Andrew A Pieper; Fiscal Year: 2013
    ..Rhesus macaques (Macaca mulatta) provide a useful proxy for efficacy in the human, as they demonstrate many features of human physiology, ..
  37. Role of Helicobacter Pylori in the Pathogenesis of Childhood Asthma
    Jay V Solnick; Fiscal Year: 2012
    ....
  38. ApoFasL as a novel treatment for Type 1 Diabetes in Nonhuman Primates
    Haval Shirwan; Fiscal Year: 2011
    ..This novel therapy has the potential to break new grounds for the clinical treatment of T1D. ..
  39. Reduced gluten cereal grains
    CHARLES PAUL MOEHS; Fiscal Year: 2013
    ..The wide adoption of RG barley and other RG grains could ultimately reduce the incidence of these conditions. Basic knowledge about the seed characteristics of RG barley may pave the way for RG wheat. ..
  40. ESTABLISHMENT OF A SPF RHESUS MACAQUE COLONY
    John L Vandeberg; Fiscal Year: 2013
    ..to contribute to the nation's capacity to produce pedigreed, specific pathogen free (SPF) rhesus monkeys (Macaca mulatta) for AIDS-related research by maintaining a production colony of Indian-origin rhesus monkeys that are SPF for ..
  41. Molecular Imaging of Inflammation in Atherosclerosis
    Jonathan R Lindner; Fiscal Year: 2012
    ..abstract_text> ..
  42. Natural Selection on Gene Regulation in Humans
    Yoav Gilad; Fiscal Year: 2013
    ..In addition, our data will allow us to determine the mechanisms that explain, at least in part, regulatory differences between the species. ..
  43. DEVELOPMENT OF A PRIMATE GENOMIC RESOURCE
    Michael G Katze; Fiscal Year: 2012
    ..upon resources constructed during the original funding period in which we developed extensive rhesus macaque (Macaca mulatta)-specific genomic tools...
  44. ESTABLISHMENT OF SPF RHESUS MACAQUE BREEDING COLONY: HIV GENOME
    Keith G Mansfield; Fiscal Year: 2011
    ..The limited availability of Indian-origin rhesus macaques (Macaca mulatta) specific pathogen free of B virus (BV), Simian T lymphotropic Virus (STLV-1), Simian Retrovirus Type D (SRV-D)..
  45. Epstein-Barr Virus: A persistent vaccine vector
    FREDERICK C WANG; Fiscal Year: 2010
    ....
  46. Intestinal cytokine and T cell homeostasis in SIV infection
    Satya Dandekar; Fiscal Year: 2013
    ....
  47. Pre-Clinical Trial of MSC-Based Therapy for CNS Disease
    Donald G Phinney; Fiscal Year: 2010
    ..stem cells (MSCs) will be injected unilaterally into the caudate putamen of infant rhesus macaques (Macaca mulatta) using stereotaxic coordinates determined by MRI...
  48. 4th International Conference on Primate Genomics
    Michael G Katze; Fiscal Year: 2010
    ..The conference highlights research activities aimed at understanding, preventing, and treating conditions such as viral hepatitis, AIDS, memory loss, drug addiction, and age-related disease. ..
  49. The NEPRC SPF Rhesus Macaque Breeding Colony
    R Paul Johnson; Fiscal Year: 2013
    ..provided by applicant): The Simian Immunodeficiency Virus (SlV)-infected Indian-origin rhesus monkey (Macaca mulatta) is the premiere animal model of human AIDS and has led to important advances in our understanding of disease ..
  50. Structure of the HIV-1 Genome
    Kevin M Weeks; Fiscal Year: 2013
    ..Over the long term, nucleotide resolution information about HIV genome structure has significant potential to identify multiple novel frameworks for designing new anti-retroviral therapeutics. ..
  51. SIMIAN VACCINE EVALUATION UNIT (SVEU)
    Phillip D Markham; Fiscal Year: 2010
    ..are as follows: 1 Acquisition and testing of non-human primates (Primary emphasis will be on rhesus macaques (Macaca mulatta) of Indian origin, Chinese-origin macaques, or other nonhuman primate species, such as pig-tail macaques (..
  52. SIMIAN VACCINE EVALUATION UNIT (SVEU)
    Dave Anderson; Fiscal Year: 2011
    ..Acquisition and testing of non-human primates (Primary emphasis will be on rhesus macaques (Macaca mulatta) of Indian origin, Chinese-origin macaques, or other nonhuman primate species, such as pig-tail macaques (..
  53. SIMIAN VACCINE EVALUATION UNITS
    Mark Lewis; Fiscal Year: 2010
    ..Acquisition and testing of non-human primates (Primary emphasis will be on rhesus macaques (Macaca mulatta) of Indian origin, Chinese-origin macaques, or other nonhuman primate species, such as pig-tail macaques (..
  54. SIMIAN VACCINE EVALUATION UNIT (SVEU)
    Phillip D Markham; Fiscal Year: 2011
    ..are as follows: 1 Acquisition and testing of non-human primates (Primary emphasis will be on rhesus macaques (Macaca mulatta) of Indian origin, Chinese-origin macaques, or other nonhuman primate species, such as pig-tail macaques (..
  55. SIMIAN VACCINE EVALUATION UNITS
    Mark Lewis; Fiscal Year: 2011
    ..Acquisition and testing of non-human primates (Primary emphasis will be on rhesus macaques (Macaca mulatta) of Indian origin, Chinese-origin macaques, or other nonhuman primate species, such as pig-tail macaques (..
  56. Studying the evolution of gene regulation at the protein level in primates
    GEORGE HERBERT PERRY; Fiscal Year: 2010
    ..species, (ii) use this platform for comparisons of human, chimpanzee (Pan troglodytes), and rhesus macaque (Macaca mulatta) liver, kidney, heart, lung and testis tissues, and (iii) examine ratios of intra- and inter-specific ..
  57. Developing a Translational Monkey Model of Maternal Care
    ERIN LORAINE KINNALLY; Fiscal Year: 2013
    ..Rhesus macaques (Macaca mulatta) are one of the best animal models of neurobehavioral development, as they are closely related to humans, and ..
  58. The Early Events Determining SIV Rectal Transmission
    Qingsheng Li; Fiscal Year: 2013
    ..abstract_text> ..
  59. MHC-BOUND, SIV-DERIVED, CTL AND HTL EPITOPES
    David I Watkins; Fiscal Year: 2011
    ..Identification of MHC alleles and definition of SIV-specific epitopes is critical in the definition of the immune response in this biomedically important system. ..
  60. MHC-BOUND, SIV-DERIVED, CTL AND HTL EPITOPES
    David I Watkins; Fiscal Year: 2013
    ..Identification of MHC alleles and definition of SIV-specific epitopes is critical in the definition of the immune response in this biomedically important system. ..
  61. FOXP2-Regulated Signaling Pathways Critical for Higher Cognitive Functions
    Genevieve Konopka; Fiscal Year: 2013
    ..abstract_text> ..
  62. Diverse Strategies to Correct the Dystrophin Gene Using Vascular Delivery (U54)
    JERRY ROY MENDELL; Fiscal Year: 2010
    ..Completion of phase I safety trials for both of these gene therapy approaches opens the gate for further vascular delivery leading to clinically meaningful results for patients. ..
  63. Recombinant antigen assays for Lassa and other arenaviru
    Robert Garry; Fiscal Year: 2005
    ....
  64. ENTERIC VIRAL INFECTIONS OF CAPTIVE RHESUS MACAQUES
    Karol Sestak; Fiscal Year: 2009
    ....
  65. Conference Support: NHP Models of Aging
    Joseph Kemnitz; Fiscal Year: 2001
    ..Because the vast majority of research in this area has been conducted in rhesus monkeys (Macaca mulatta), the entire second day will focus exclusively on studies using this species- The morning session will include ..
  66. Plasticity of the Visual Cortex
    Stelios Smirnakis; Fiscal Year: 2006
    ..of reorganization triggered by an acute retinal scotoma in the visual cortex of human and non-human primates (macaca mulatta)...
  67. PALLIDAL PHYSIOLOGY IN HUMAN AND PRIMATE DYSTONIA
    PHILIP STARR; Fiscal Year: 2005
    ..Development of an animal model in a large nonhuman primate will open the possibility for further detailed investigations of basal ganglia physiology in dystonia, beyond those which are possible during human surgery. ..
  68. Bone marrow monocyte output and virus import into the CNS in acute SIV infection
    Michael McChesney; Fiscal Year: 2009
    ....
  69. SPECIFIC PATHOGEN FREE MACAQUE BREEDING PROGRAM
    M Izard; Fiscal Year: 1999
    ..The recent discovery that pigtail macaques can be infected with HIV ensures that two macaque species (Macaca mulatta and nemestrina) will continue to be the most consistently and widely used animal model for AIDS and other ..
  70. RELATION BETWEEN SPACE AND AGGRESSION IN RHESUS MACAQUES
    Frans De Waal; Fiscal Year: 1992
    Research institutions have recently come under attack for trauma in their rhesus monkeys (Macaca mulatta). The fighting is blamed on crowded housing conditions...
  71. HIV PROTEASE INHIBITORS EFFECT--NENDOTHELIAL DYSFUNCTION
    Changyi Chen; Fiscal Year: 2004
    ..Together, the integrated basic science, non-human primate and human investigations offer a multi disciplinary approach to the understanding and prevention of protease inhibitor-associated vascular complications. ..
  72. NEURAL MECHANISMS OF SIZE PERCEPTION
    John Allman; Fiscal Year: 2001
    ..representations in cortical areas for object vision, V1, V2, V4, and IT in awake, behaving macaque monkeys (Macaca mulatta)...
  73. Novel Vaginal Microbicides Based On Stable AAV-Neutralizing Antibody Gene Transfe
    Wayne Marasco; Fiscal Year: 2009
    ..A protective genetic microbicide delivered to the female lower genital track could dramatically slow the spread of HIV/AIDS. ..