macaca fascicularis

Summary

Summary: A species of the genus MACACA which typically lives near the coast in tidal creeks and mangrove swamps primarily on the islands of the Malay peninsula.

Top Publications

  1. ncbi Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques
    Guangmei Yan
    The South China Center for Innovative Pharmaceuticals, Guangzhou, China
    Nat Biotechnol 29:1019-23. 2011
  2. ncbi Nature and interaction of signals from the receptive field center and surround in macaque V1 neurons
    James R Cavanaugh
    Center for Neural Science, New York University, New York City, New York 10003, USA
    J Neurophysiol 88:2530-46. 2002
  3. pmc TRIMCyp expression in Old World primates Macaca nemestrina and Macaca fascicularis
    Greg Brennan
    Departments of Microbiology and Pharmaceutics, and Washington National Primate Research Center, University of Washington, Seattle, WA 98121, USA
    Proc Natl Acad Sci U S A 105:3569-74. 2008
  4. pmc Representational format determines numerical competence in monkeys
    Vanessa Schmitt
    Cognitive Ethology Laboratory, German Primate Center, Gottingen, Göttingen 37077, Germany
    Nat Commun 2:257. 2011
  5. ncbi Effect of blast exposure on the brain structure and cognition in Macaca fascicularis
    Jia Lu
    Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore 117510
    J Neurotrauma 29:1434-54. 2012
  6. pmc A single amino acid of the human immunodeficiency virus type 2 capsid affects its replication in the presence of cynomolgus monkey and human TRIM5alphas
    Haihan Song
    Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    J Virol 81:7280-5. 2007
  7. pmc Early target cells of measles virus after aerosol infection of non-human primates
    Ken Lemon
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University of Belfast, Belfast, United Kingdom
    PLoS Pathog 7:e1001263. 2011
  8. pmc Architecture and neurocytology of monkey cingulate gyrus
    Brent A Vogt
    Cingulum NeuroSciences Institute, Manlius, New York 13104, USA
    J Comp Neurol 485:218-39. 2005
  9. pmc Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection
    Thomas W Geisbert
    United States Army Medical Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Am J Pathol 163:2347-70. 2003
  10. pmc A specific region of 37 amino acid residues in the SPRY (B30.2) domain of African green monkey TRIM5alpha determines species-specific restriction of simian immunodeficiency virus SIVmac infection
    Emi E Nakayama
    Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Shi, Osaka 565 0871, Japan
    J Virol 79:8870-7. 2005

Research Grants

  1. Development of an Anti-PSGL-1 Antibody to Treat Crohn's Disease
    Scott A Rollins; Fiscal Year: 2011
  2. The Immunogenetics of Macaques Used in Biodefense Research
    ALESSANDRO D SETTE; Fiscal Year: 2011
  3. Myocardial passive stiffness: effect of aging.
    WILLIAM CORSON HUNTER; Fiscal Year: 2010
  4. SIMIAN VACCINE EVALUATION UNIT (SVEU)
    Dave Anderson; Fiscal Year: 2011
  5. SIMIAN VACCINE EVALUATION UNIT (SVEU)
    Phillip D Markham; Fiscal Year: 2011
  6. SIMIAN VACCINE EVALUATION UNIT (SVEU)
    Phillip D Markham; Fiscal Year: 2010
  7. SIMIAN VACCINE EVALUATION UNITS
    Mark Lewis; Fiscal Year: 2011
  8. SIMIAN VACCINE EVALUATION UNITS
    Mark Lewis; Fiscal Year: 2010
  9. Primate iPS lines using Retrovirus and TAT Protein Transduction
    COLIN EDWARD BISHOP; Fiscal Year: 2010
  10. An Experimental Investigation into Staging CTS Utilizing Portable Ultrasound...
    Kevin D Evans; Fiscal Year: 2011

Detail Information

Publications259 found, 100 shown here

  1. ncbi Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques
    Guangmei Yan
    The South China Center for Innovative Pharmaceuticals, Guangzhou, China
    Nat Biotechnol 29:1019-23. 2011
    ..However, we identify several putatively dysfunctional genetic differences between the three macaque species, which may explain functional differences between them previously observed in clinical studies...
  2. ncbi Nature and interaction of signals from the receptive field center and surround in macaque V1 neurons
    James R Cavanaugh
    Center for Neural Science, New York University, New York City, New York 10003, USA
    J Neurophysiol 88:2530-46. 2002
    ..Input to the suppressive surround may come in part from feedback signals from higher areas...
  3. pmc TRIMCyp expression in Old World primates Macaca nemestrina and Macaca fascicularis
    Greg Brennan
    Departments of Microbiology and Pharmaceutics, and Washington National Primate Research Center, University of Washington, Seattle, WA 98121, USA
    Proc Natl Acad Sci U S A 105:3569-74. 2008
    ..RT-PCR of total RNA from M. nemestrina and Macaca fascicularis yielded three TRIMCyp amplification products, one of which is predicted to encode a TRIMCyp chimera ..
  4. pmc Representational format determines numerical competence in monkeys
    Vanessa Schmitt
    Cognitive Ethology Laboratory, German Primate Center, Gottingen, Göttingen 37077, Germany
    Nat Commun 2:257. 2011
    ..Reward replacement apparently facilitated representation of the food items as signifiers for other foods, which in turn supported a higher acuity in decision making...
  5. ncbi Effect of blast exposure on the brain structure and cognition in Macaca fascicularis
    Jia Lu
    Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore 117510
    J Neurotrauma 29:1434-54. 2012
    ....
  6. pmc A single amino acid of the human immunodeficiency virus type 2 capsid affects its replication in the presence of cynomolgus monkey and human TRIM5alphas
    Haihan Song
    Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    J Virol 81:7280-5. 2007
    ..Mutagenesis studies indicated that the single amino acid at the 120th position indeed affected the sensitivity of the virus to CM TRIM5alpha...
  7. pmc Early target cells of measles virus after aerosol infection of non-human primates
    Ken Lemon
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University of Belfast, Belfast, United Kingdom
    PLoS Pathog 7:e1001263. 2011
    ....
  8. pmc Architecture and neurocytology of monkey cingulate gyrus
    Brent A Vogt
    Cingulum NeuroSciences Institute, Manlius, New York 13104, USA
    J Comp Neurol 485:218-39. 2005
    ..This major revision of the architectural organization of monkey cingulate cortex provides a new context for connection studies and for devising models of neuron diseases...
  9. pmc Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection
    Thomas W Geisbert
    United States Army Medical Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Am J Pathol 163:2347-70. 2003
    ..The sequence of pathogenetic events identified in this study should provide new targets for rational prophylactic and chemotherapeutic interventions...
  10. pmc A specific region of 37 amino acid residues in the SPRY (B30.2) domain of African green monkey TRIM5alpha determines species-specific restriction of simian immunodeficiency virus SIVmac infection
    Emi E Nakayama
    Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Shi, Osaka 565 0871, Japan
    J Virol 79:8870-7. 2005
    ..These findings clearly indicated that a specific region of 37 amino acid residues in the SPRY domain of CV1-TRIM5alpha contained a determinant of species-specific restriction of SIVmac...
  11. ncbi Mitochondrial DNA sequence phylogeny of 4 populations of the widely distributed cynomolgus macaque (Macaca fascicularis fascicularis)
    Antoine Blancher
    Laboratoire d Immunogenetique moleculaire, Universite Paul Sabatier, Toulouse, France
    J Hered 99:254-64. 2008
    We studied the mitochondrial DNA (mtDNA) polymorphism of 304 Macaca fascicularis fascicularis (M. f. fascicularis) individuals, representative of 4 cynomolgus macaque populations (Indochina, Indonesia, Philippines, and Mauritius)...
  12. pmc Genome-based analysis of the nonhuman primate Macaca fascicularis as a model for drug safety assessment
    Martin Ebeling
    Translational Research Sciences, F Hoffmann La Roche AG, Pharmaceutical Research and Early Development, 4070 Basel, Switzerland
    Genome Res 21:1746-56. 2011
    The long-tailed macaque, also referred to as cynomolgus monkey (Macaca fascicularis), is one of the most important nonhuman primate animal models in basic and applied biomedical research...
  13. ncbi MHC haplotype frequencies in a UK breeding colony of Mauritian cynomolgus macaques mirror those found in a distinct population from the same geographic origin
    Edward T Mee
    Division of Retrovirology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Hertfordshire, UK
    J Med Primatol 38:1-14. 2009
    ..Mauritian cynomolgus macaques have greatly restricted genetic diversity in the MHC region compared to other non-human primates; however, the frequency of common MHC haplotypes among captive-bred populations has not been reported...
  14. pmc Variable prevalence and functional diversity of the antiretroviral restriction factor TRIMCyp in Macaca fascicularis
    Elizabeth A Dietrich
    Department of Microbiology, University of Washington, Seattle, WA 98121, USA
    J Virol 85:9956-63. 2011
    ..TRIMCyp has so far been found in four species of Asian macaques, Macaca fascicularis, M. mulatta, M. nemestrina, and M. leonina. M...
  15. ncbi Induction of neutralizing antibodies and partial protection from viral challenge in Macaca fascicularis immunized with recombinant dengue 4 virus envelope glycoprotein expressed in Pichia pastoris
    Maria G Guzman
    Virology Department, Pan American Health Organization World Health Organization Collaborating Center for Viral Diseases, Pedro Kouri Tropical Medicine Institute, Autopista Novia del Mediodia, Havana, Cuba
    Am J Trop Med Hyg 69:129-34. 2003
    ..that expresses the envelope (E) gene of dengue virus type 4 was tested for immunogenicity and protection in Macaca fascicularis. One hundred micrograms of semipurified recombinant E protein (E4rec) expressed in Pichia pastoris was used ..
  16. pmc Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43
    Azusa Uchida
    Department of Neurology and Neurological Science, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Brain 135:833-46. 2012
    ....
  17. pmc Geographical, genetic and functional diversity of antiretroviral host factor TRIMCyp in cynomolgus macaque (Macaca fascicularis)
    Akatsuki Saito
    Primate Research Institute, Kyoto University, Inuyama 484 8506, Japan
    J Gen Virol 93:594-602. 2012
    ..three species of Old World monkey: rhesus (Macaca mulatta), pig-tailed (Macaca nemestrina) and cynomolgus (Macaca fascicularis) macaques...
  18. ncbi Superior area 6 afferents from the superior parietal lobule in the macaque monkey
    M Matelli
    Istituto di Fisiologia Umana, Universita di Parma, Italy
    J Comp Neurol 402:327-52. 1998
    ..The two remaining circuits appear to be involved in different aspects of visuomotor transformations...
  19. pmc In vivo tropism of attenuated and pathogenic measles virus expressing green fluorescent protein in macaques
    Rory D de Vries
    Department of Virology, Erasmus MC, P O Box 2040, 3000 CA, Rotterdam, Netherlands
    J Virol 84:4714-24. 2010
    ..This study shows that despite in vitro differences, attenuated and pathogenic MV show highly similar in vivo tropism in the lungs. However, systemic spread of attenuated MV is restricted...
  20. pmc Characterization of Mauritian cynomolgus macaque major histocompatibility complex class I haplotypes by high-resolution pyrosequencing
    Melisa L Budde
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, WI 53705, USA
    Immunogenetics 62:773-80. 2010
    ..Overall, this approach significantly expanded our knowledge of MCM haplotypes and will facilitate future studies on disease pathogenesis and protective cellular immunity...
  21. ncbi Comparison of anti-viral activity of rhesus monkey and cynomolgus monkey TRIM5alphas against human immunodeficiency virus type 2 infection
    Ken Kono
    Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, 3 1, Yamada oka, Suita Shi, Osaka 565 0871, Japan
    Virology 373:447-56. 2008
    ..Furthermore, a mutagenesis study showed that three amino acid residues TFP at the 339th to 341st positions of Rh TRIM5alpha are important for restricting HIV-2 strains resistant to CM TRIM5alpha...
  22. pmc IL-2 simultaneously expands Foxp3+ T regulatory and T effector cells and confers resistance to severe tuberculosis (TB): implicative Treg-T effector cooperation in immunity to TB
    Crystal Y Chen
    Department of Microbiology and Immunology, Center for Primate Biomedical Research, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Immunol 188:4278-88. 2012
    ..Thus, IL-2 can simultaneously activate and expand T effector cells and Foxp3(+) Treg populations and confer resistance to severe TB without enhancing M. tuberculosis infection...
  23. pmc Old world monkeys compare to apes in the primate cognition test battery
    Vanessa Schmitt
    Cognitive Ethology Lab, German Primate Center, Gottingen, Germany
    PLoS ONE 7:e32024. 2012
    ..One limitation, however, is that the initial experiments were devised to tap into human specific skills in the first place, thus potentially underestimating both true nonhuman primate competencies as well as species differences...
  24. ncbi Bilateral actions of the reticulospinal tract on arm and shoulder muscles in the monkey: stimulus triggered averaging
    Adam G Davidson
    Neuroscience Graduate Studies Program, The Ohio State University, 1583 Perry Street, Rm 516G, Columbus, OH 43210, USA
    Exp Brain Res 173:25-39. 2006
    ..averages (StimulusTA) were constructed from muscles of both upper limbs while two awake monkeys (Macaca fascicularis) performed a reaching task using either arm...
  25. ncbi Enhanced GDNF expression in dopaminergic cells of monkeys grafted with carotid body cell aggregates
    M R Luquin
    Laboratory of Regenerative Therapy, Centre for Applied Medical Research CIMA, University of Navarra, 31008 Pamplona, Navarra, Spain
    Brain Res 1375:120-7. 2011
    ....
  26. ncbi Modeling depression in adult female cynomolgus monkeys (Macaca fascicularis)
    Stephanie L Willard
    Integrative Neuroscience Graduate Program, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Am J Primatol 74:528-42. 2012
    ..The nonhuman primate model represents a new animal model of depression with great promise for furthering our understanding of this prevalent and debilitating disease and identifying novel therapeutic targets...
  27. ncbi TRIM5 allelic polymorphism in macaque species/populations of different geographic origins: its impact on SIV vaccine studies
    N G de Groot
    Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Tissue Antigens 78:256-62. 2011
    ..In addition, we have re-evaluated historical samples of rhesus macaques challenged with SIV(mac251), a virus that has been reported to be partially suppressed by particular rhesus macaque TRIM5 variants...
  28. ncbi Aetiology: Koch's postulates fulfilled for SARS virus
    Ron A M Fouchier
    Department of Virology, Erasmus Medical Centre, 3015 GE Rotterdam, The Netherlands
    Nature 423:240. 2003
  29. pmc Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246
    John Huggins
    U S Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA
    Antimicrob Agents Chemother 53:2620-5. 2009
    ..The data indicate that oral dosing once per day with ST-246 protects animals from poxvirus disease, as measured by reductions in viral load and numbers of lesions and enhancement of survival...
  30. pmc Effect of a short-term HAART on SIV load in macaque tissues is dependent on time of initiation and antiviral diffusion
    Olivier Bourry
    CEA, Division of Immuno Virology, DSV iMETI, Fontenay aux Roses, France
    Retrovirology 7:78. 2010
    ....
  31. ncbi Preladenant, a selective A(2A) receptor antagonist, is active in primate models of movement disorders
    Robert A Hodgson
    Department of Neurobiology, Merck and Co Inc, Kenilworth, NJ 07033, USA
    Exp Neurol 225:384-90. 2010
    ..3-3.0 mg/kg; PO) delayed the onset of EPS symptoms evoked by an acute haloperidol challenge. Collectively, these data support the use of preladenant for the treatment of PD and antipsychotic-induced movement disorders...
  32. ncbi A combination HIV vaccine based on Tat and Env proteins was immunogenic and protected macaques from mucosal SHIV challenge in a pilot study
    Flavia Ferrantelli
    National AIDS Center, Istituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
    Vaccine 29:2918-32. 2011
    ....
  33. pmc Morphologic comparison of cervical, thoracic, lumbar intervertebral discs of cynomolgus monkey (Macaca fascicularis)
    Umile Giuseppe Longo
    Orthopaedic Department, Universita Campus BioMedico, Rome, Italy
    Eur Spine J 15:1845-51. 2006
    ..vertebral motion segments were obtained from the spine of nine 3 to 4-year-old cynomolgus monkeys (Macaca fascicularis). From every spine, five discs were sectioned (C5-C6, T3-T4, T9-T10, L2-L3, L4-L5)...
  34. pmc A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates
    Laszlo Kari
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Exp Med 208:2217-23. 2011
    ..Epidemiological models of trachoma control indicate that a vaccine with this degree of efficacy would significantly reduce the prevalence of infection and rates of reinfection, known risk factors which drive blinding disease...
  35. pmc Prediction of infarct volume and neurologic outcome by using automated multiparametric perfusion-weighted magnetic resonance imaging in a primate model of permanent middle cerebral artery occlusion
    Makoto Sasaki
    Advanced Medical Research Center, Iwate Medical University, Morioka, Japan
    J Cereb Blood Flow Metab 31:448-56. 2011
    ..At optimum threshold, AT, CBV, TTP, T(max), and deconvolution CBF can accurately predict the final infarct volume and neurologic outcome in monkeys with permanent MCA occlusion...
  36. ncbi Trial-to-trial variability of spike response of V1 and saccadic response time
    Jungah Lee
    Department of Psychology, Seoul National University, Seoul, Korea
    J Neurophysiol 104:2556-72. 2010
    ..These results demonstrate that the trial-to-trial variability of neural response in V1 propagates to the stage of saccade execution, resulting in trial-to-trial variability of RT of a visually guided saccade...
  37. ncbi Age-related changes of Alzheimer's disease-associated proteins in cynomolgus monkey brains
    Nobuyuki Kimura
    Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biochem Biophys Res Commun 310:303-11. 2003
    ....
  38. ncbi Localization of relaxin-3 in brain of Macaca fascicularis: identification of a nucleus incertus in primate
    Sherie Ma
    Florey Neuroscience Institutes, The University of Melbourne, Victoria 3010, Australia
    J Comp Neurol 517:856-72. 2009
    ..In this study we describe the distribution of RLN3 neurons in the brain of macaque (Macaca fascicularis) using in situ hybridization histochemistry and immunohistochemistry...
  39. pmc Antigen capture enzyme-linked immunosorbent assay for specific detection of Reston Ebola virus nucleoprotein
    Tetsuro Ikegami
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208 0011, Japan
    Clin Diagn Lab Immunol 10:552-7. 2003
    ..The antigen capture ELISAs using Res2-6C8 and Res2-1D8 are useful for the rapid detection of the NP in EBO-R-infected cynomolgus macaques...
  40. ncbi The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21
    Alexei Kharitonenkov
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Endocrinology 148:774-81. 2007
    ..These data support the development of FGF-21 for the treatment of diabetes and other metabolic diseases...
  41. ncbi Aerosol exposure to the angola strain of marburg virus causes lethal viral hemorrhagic Fever in cynomolgus macaques
    D A Alves
    Center for Vaccine Research, University of Pittsburgh, 8037 BST3, 3051 Fifth Avenue, Pittsburgh, PA 15261, USA
    Vet Pathol 47:831-51. 2010
    ..These macaques exhibited a number of features similar to those of human filovirus infections; as such, this model of aerosolized MARV-Angola might be useful in developing medical countermeasures under the Animal Rule...
  42. ncbi Visual spatial characterization of macaque V1 neurons
    M P Sceniak
    The Salk Institute, La Jolla, California 92037, USA
    J Neurophysiol 85:1873-87. 2001
    ..The two models yield quantitatively similar estimates of the extent of excitation and inhibition. However, the normalization (divisive) model predicts weaker surround strength than the DOG model...
  43. pmc Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: what have we learned?
    Rong Deng
    Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech Inc, South San Francisco, CA, USA
    MAbs 3:61-6. 2011
    ....
  44. pmc Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells
    D Eastwood
    Biotherapeutics Group, NIBSC, Potters Bar, Hertfordshire, UK
    Br J Pharmacol 161:512-26. 2010
    ..Here, we have identified a species difference almost certainly responsible for this disparate immunopharmacology...
  45. pmc Complete characterization of killer Ig-like receptor (KIR) haplotypes in Mauritian cynomolgus macaques: novel insights into nonhuman primate KIR gene content and organization
    Benjamin N Bimber
    Department of Pathology and Laboratory Medicine, Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53706, USA
    J Immunol 181:6301-8. 2008
    ..The findings from this study fundamentally advance our understanding of KIR genetics in nonhuman primates and establish a foundation from which to study KIR signaling in disease pathogenesis...
  46. ncbi Ebola virus-like particle-based vaccine protects nonhuman primates against lethal Ebola virus challenge
    Kelly L Warfield
    US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    J Infect Dis 196:S430-7. 2007
    ..We previously had demonstrated the protective efficacy of virus-like particle (VLP)-based vaccines against EBOV and MARV infection in rodents...
  47. ncbi Safety, antigenicity, and efficacy of a recombinant coccidioidomycosis vaccine in cynomolgus macaques (Macaca fascicularis)
    Suzanne M Johnson
    D V M M P V M, California National Primate Research Center, University of California, Davis, CA 95616, USA
    Ann N Y Acad Sci 1111:290-300. 2007
    ..Additional experiments may be needed to optimize the vaccination and to confer greater protection against lethal challenge...
  48. pmc Extralymphoid CD8+ T cells resident in tissue from simian immunodeficiency virus SIVmac239{Delta}nef-vaccinated macaques suppress SIVmac239 replication ex vivo
    Justin M Greene
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 585 Science Drive, Madison, WI 53711, USA
    J Virol 84:3362-72. 2010
    ..Moreover, these results underscore the limitations of relying on immunological measurements from peripheral blood lymphocytes in studies of protective immunity to HIV/SIV...
  49. ncbi Resistance to superinfection by a vigorously replicating, uncloned stock of simian immunodeficiency virus (SIVmac251) stimulates replication of a live attenuated virus vaccine (SIVmacC8)
    Neil Berry
    Division of Retrovirology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK
    J Gen Virol 89:2240-51. 2008
    ..In naïve, Mauritian-derived cynomolgus macaques (Macaca fascicularis), SIVmac32H/L28 replicated to high peak titres (>10(8) SIV RNA copies ml(-1)), persisted at high levels ..
  50. pmc CD8+ lymphocytes do not mediate protection against acute superinfection 20 days after vaccination with a live attenuated simian immunodeficiency virus
    Richard Stebbings
    Division of Immunology, NIBSC, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, United Kingdom
    J Virol 79:12264-72. 2005
    ....
  51. ncbi 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties
    Edwin B Villhauer
    Novartis Institute for Biomedical Research, One Health Plaza, East Hanover, New Jersey 07936, USA
    J Med Chem 46:2774-89. 2003
    ..The results suggest that 12j is a potent, stable, selective DPP-IV inhibitor possessing excellent oral bioavailability and potent antihyperglycemic activity with potential for once-a-day administration...
  52. pmc Reaching activity in parietal area V6A of macaque: eye influence on arm activity or retinocentric coding of reaching movements?
    Nicoletta Marzocchi
    Dipartimento di Fisiologia Umana e Generale, Universita di Bologna, I 40126 Bologna, Italy
    Eur J Neurosci 27:775-89. 2008
    ....
  53. ncbi Contribution of the monkey frontal eye field to covert visual attention
    Claire Wardak
    Institut des Sciences Cognitives, Unité Mixte de Recherche 5015, Centre National de la Recherche Scientifique Université Claude Bernard Lyon I, 69675 Bron, France
    J Neurosci 26:4228-35. 2006
    ....
  54. ncbi Anatomical evidence of multimodal integration in primate striate cortex
    Arnaud Falchier
    Institut National de la Santé et de la Recherche Médicale U371, Cerveau et Vision, 69675 Bron Cedex, France
    J Neurosci 22:5749-59. 2002
    ..Direct projections from auditory and STP cortex to peripheral area 17 have important consequences for higher visual functions of area 17, including multimodal integration at early stages of the visual cortical pathway...
  55. pmc Susceptibilities of nonhuman primates to chronic wasting disease
    Brent Race
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    Emerg Infect Dis 15:1366-76. 2009
    ..Thus, these 2 species differed in susceptibility to CWD. Because humans are evolutionarily closer to macaques than to squirrel monkeys, they may also be resistant to CWD...
  56. ncbi Cortical connections of the visuomotor parietooccipital area V6Ad of the macaque monkey
    Michela Gamberini
    Dipartimento di Fisiologia Umana e Generale, Universita di Bologna, Italy
    J Comp Neurol 513:622-42. 2009
    ..injected into the dorsal part of the anterior bank of parietooccipital sulcus of seven macaque monkeys (Macaca fascicularis). The limits of injection sites were compared with those of cytoarchitectonic fields...
  57. pmc Modification of a loop sequence between alpha-helices 6 and 7 of virus capsid (CA) protein in a human immunodeficiency virus type 1 (HIV-1) derivative that has simian immunodeficiency virus (SIVmac239) vif and CA alpha-helices 4 and 5 loop improves replic
    Ayumu Kuroishi
    Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Retrovirology 6:70. 2009
    ....
  58. ncbi Short-term depression of synaptic transmission during stimulation in the globus pallidus of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates
    Yaara Erez
    Gonda Brain Research Center, Bar Ilan University, Ramat Gan 52900, Israel
    J Neurosci 29:7797-802. 2009
    ....
  59. pmc Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates
    Michelle H Larsen
    Albert Einstein College of Medicine, Bronx, NY 1461, USA
    Vaccine 27:4709-17. 2009
    ..BCG vaccinates had reduced tuberculosis-associated pathology and improved clinical scores as compared to saline and mc(2)6030 vaccinates, but survival did not differ among the groups...
  60. ncbi Differences in the corticospinal projection from primary motor cortex and supplementary motor area to macaque upper limb motoneurons: an anatomical and electrophysiological study
    M A Maier
    INSERM U 483, Universite Pierre et Marie Curie, 75005 Paris, France
    Cereb Cortex 12:281-96. 2002
    ..Thus although they may function in parallel, the two CM projections probably make different contributions to upper limb motor control...
  61. pmc Experimental Mycobacterium tuberculosis infection of cynomolgus macaques closely resembles the various manifestations of human M. tuberculosis infection
    Saverio V Capuano
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Infect Immun 71:5831-44. 2003
    ..In addition, this model will provide an opportunity to study the latent M. tuberculosis infection observed in approximately 90% of all infected humans...
  62. ncbi Infection of cynomolgus macaques (Macaca fascicularis) and rhesus macaques (Macaca mulatta) with different wild-type measles viruses
    H Sittana El Mubarak
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    J Gen Virol 88:2028-34. 2007
    ..MV-Sudan proved more pathogenic for non-human primates than MV-Bil, which may render it more suitable for use in future pathogenesis studies...
  63. ncbi MHC class I A loci polymorphism and diversity in three Southeast Asian populations of cynomolgus macaque
    Yuki F Kita
    Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1143, Japan
    Immunogenetics 61:635-48. 2009
    Cynomolgus macaques (Macaca fascicularis, Mafa) have emerged as important animal models for biomedical research, necessitating a more extensive characterization of their major histocompatibility complex polymorphic regions...
  64. ncbi Response facilitation from the "suppressive" receptive field surround of macaque V1 neurons
    Jennifer M Ichida
    Department of Ophthalmology, University of Utah, Salt Lake City, UT 84132, USA
    J Neurophysiol 98:2168-81. 2007
    ..This strongly suggests that feedforward connections do not contribute to far-surround modulation and that the latter is generated by intra-cortical mechanisms, likely involving top-down feedback...
  65. ncbi Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia
    Incarnation Aubert
    Centre National de la Recherche Scientifique Unite Mixte de Recherche 5541, Bordeaux Cedex, France
    Ann Neurol 57:17-26. 2005
    ..Our data suggest that levodopa-induced dyskinesia results from increased dopamine D(1) receptor-mediated transmission at the level of the direct pathway...
  66. ncbi Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure
    Carlos Barcia
    Experimental Neurology and Neurosurgery Group, Department of Human Anatomy and Psychobiology, School of Medicine, University of Murcia, Murcia, Spain
    Glia 46:402-9. 2004
    ..These data suggest that neurodegeneration was still active despite the absence of the agent triggering cell death and that the glial reaction is associated with long-term neurodegeneration...
  67. ncbi L-Dopa treatment abolishes the numerical increase in striatal dopaminergic neurons in parkinsonian monkeys
    Philippe Huot
    Centre de Recherche Universite Laval Robert Giffard, 2601, de la Canardière, Local F 6500, Quebec, Que, Canada G1J 2G3
    J Chem Neuroanat 35:77-84. 2008
    ..visualized with tyrosine hydroxylase (TH) immunohistochemistry, was measured in three groups of cynomolgus (Macaca fascicularis) monkeys: (1) normal untreated monkeys; (2) monkeys rendered parkinsonian following systemic injection of 1-..
  68. ncbi Characterisation of MHC haplotypes in a breeding colony of Indonesian cynomolgus macaques reveals a high level of diversity
    Jane L Mitchell
    Division of Retrovirology, National Institute for Biological Standards and Control, Health Protection Agency, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK
    Immunogenetics 64:123-9. 2012
    ..Further, definition of the MHC diversity of the population satisfies one of the prerequisites to MHC association studies and detailed immunological investigations in this outbred non-human primate species...
  69. ncbi Mild testicular hyperthermia induces profound transitional spermatogenic suppression through increased germ cell apoptosis in adult cynomolgus monkeys (Macaca fascicularis)
    Yan He Lue
    Department of Medicine, Harbor UCLA Medical Center and Research and Education Institute, University of California, Davis 90509, USA
    J Androl 23:799-805. 2002
    ..Three adult Cynomolgus monkeys (Macaca fascicularis) were used in this study...
  70. pmc Extensive DRB region diversity in cynomolgus macaques: recombination as a driving force
    Gaby G M Doxiadis
    Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, P O Box 3306, 2280 GH, Rijswijk, The Netherlands
    Immunogenetics 62:137-47. 2010
    ..This undocumented high level of DRB region configuration-associated diversity most likely represents a species-specific strategy to cope with various pathogens...
  71. pmc FoxP3+ CD25+ CD8+ T-cell induction during primary simian immunodeficiency virus infection in cynomolgus macaques correlates with low CD4+ T-cell activation and high viral load
    Ingrid Karlsson
    CEA, Service d Immuno Virologie, DSV iMETI, IPSC, Fontenay aux Roses, France
    J Virol 81:13444-55. 2007
    ....
  72. ncbi Diversity of TRIM5α and TRIMCyp sequences in cynomolgus macaques from different geographical origins
    Neil J Berry
    Division of Retrovirology, National Institute for Biological Standards and Control, A Centre of the Health Protection Agency, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, UK
    Immunogenetics 64:267-78. 2012
    ..The level of allelic diversity reported here is greater than previously proposed for cynomolgus macaque species...
  73. ncbi Clinical veterinarian's perspective of non-human primate (NHP) use in drug safety studies
    Katrina Taylor
    Bristol Myers Squibb Research and Development, Veterinary Science, Syracuse, NY 13057, USA
    J Immunotoxicol 7:114-9. 2010
    Owing to their size, cost, and availability, the cynomolgus macaque (Macaca fascicularis) has surpassed the rhesus macaque in its use as a non-human primate preclinical model for drug safety studies...
  74. pmc Thoracic radiography as a refinement methodology for the study of H1N1 influenza in cynomologus macaques (Macaca fascicularis)
    Douglas L Brining
    Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    Comp Med 60:389-95. 2010
    ..the use of thoracic radiography as a noninvasive refinement methodology for the cynomologus macaque (Macaca fascicularis) model of H1N1 infection...
  75. ncbi Transient testicular warming enhances the suppressive effect of testosterone on spermatogenesis in adult cynomolgus monkeys (Macaca fascicularis)
    Yanhe Lue
    Division of Endocrinology and Metabolism, Harbor University of California, Los Angeles Medical Center, Box 446, 1000 West Carson Street, Torrance, CA 90509, USA
    J Clin Endocrinol Metab 91:539-45. 2006
    ..The context of the study was to examine whether combined testosterone (T) and heat (H) treatment have additive or synergistic effects on suppression of spermatogenesis...
  76. ncbi Stimulus dependence of neuronal correlation in primary visual cortex of the macaque
    Adam Kohn
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 25:3661-73. 2005
    ....
  77. ncbi Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques
    Yasuhiro Uno
    Genome Research Group, Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd, 16 1 Minami Akasaka, Kainan, Wakayama 642 0017, Japan
    Drug Metab Dispos 38:209-14. 2010
    ..Information on genetic diversity of macaque CYP3A4 and CYP3A5 presented here could be useful for successful drug metabolism studies conducted in macaques...
  78. pmc ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification
    Robert Jordan
    SIGA Technologies, Inc, 4575 SW Research Way, Suite 230, Corvallis, OR 97333, USA
    Antimicrob Agents Chemother 53:1817-22. 2009
    ..These results suggest that administration of an oral dosage of 400 mg once daily for 14 days will be effective for the prevention or treatment of smallpox or monkeypox infections in humans...
  79. ncbi Spinogenesis and pruning in the primary auditory cortex of the macaque monkey (Macaca fascicularis): an intracellular injection study of layer III pyramidal cells
    Guy N Elston
    Centre for Cognitive Neuroscience, 60 Duke Rd, Doonan, Sunshine Coast, Queensland, 4562, Australia
    Brain Res 1316:35-42. 2010
    ..Such differences in the growth profiles of neocortical pyramidal cells among cortical areas may influence therapeutic outcomes when applying new technologies such as neurotrophic delivery devices or stem cell therapy...
  80. ncbi Involvement of sensorimotor, limbic, and associative basal ganglia domains in L-3,4-dihydroxyphenylalanine-induced dyskinesia
    Celine Guigoni
    Basal Gang, Centre National de la Recherche Scientifique CNRS Unité Mixte de Recherche UMR 5543, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux Cedex, France
    J Neurosci 25:2102-7. 2005
    ..We propose that these metabolic changes reflect the underlying neural mechanisms of not simply motor dyskinesias but also affective, motivational, and cognitive disorders associated with long-term exposure to L-dopa...
  81. pmc Single nucleotide polymorphisms (SNPs) are highly conserved in rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques
    Summer L Street
    Genetics Research and Informatics Program, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, OR 97006, USA
    BMC Genomics 8:480. 2007
    b>Macaca fascicularis (cynomolgus or longtail macaques) is the most commonly used non-human primate in biomedical research...
  82. pmc Early and strong immune responses are associated with control of viral replication and recovery in lassa virus-infected cynomolgus monkeys
    Sylvain Baize
    Unité de Biologie des Infections Virales Emergentes, Institut Pasteur IFR 128 BioSciences Gerland Lyon Sud, Lyon, France
    J Virol 83:5890-903. 2009
    ....
  83. ncbi Expressed sequence tags from cynomolgus monkey (Macaca fascicularis) liver: a systematic identification of drug-metabolizing enzymes
    Yasuhiro Uno
    Division of Genetic Diagnosis, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    FEBS Lett 582:351-8. 2008
    ..Our comparative genomics approach identified nine lineage-specific candidate ESTs, including three drug-metabolizing enzymes, which could be important for understanding the physiological differences between monkeys and humans...
  84. ncbi Induction and maintenance of ethanol self-administration in cynomolgus monkeys (Macaca fascicularis): long-term characterization of sex and individual differences
    J A Vivian
    Center for the Neurobehavioral Study of Alcohol, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Alcohol Clin Exp Res 25:1087-97. 2001
    ..METHODS: Eight male and eight female adult cynomolgus monkeys (Macaca fascicularis) were exposed to daily oral ethanol self-administration sessions for approximately 9 months...
  85. pmc Functional organization of color domains in V1 and V2 of macaque monkey revealed by optical imaging
    Haidong D Lu
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    Cereb Cortex 18:516-33. 2008
    ..We conclude that color and orientation-selective responses are preferentially located in distinct CO compartments in V1 and V2. We propose that the term "blob" encompasses both the concept of "CO blob" and "color domain" in V1...
  86. ncbi Ancient genome-wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta
    Naoki Osada
    Department of Biomedical Resources, National Institute of Biomedical Innovation, 7 6 8 Saito Asagi, Ibraki, Osaka 567 0085, Japan
    Mol Ecol 19:2884-95. 2010
    b>Macaca fascicularis and Macaca mulatta are two of the most commonly used laboratory macaques, yet their genetic differences at a genome-wide level remain unclear...
  87. ncbi Safety and efficacy of regional intravenous (r.i.) versus intramuscular (i.m.) delivery of rAAV1 and rAAV8 to nonhuman primate skeletal muscle
    Alice Toromanoff
    INSERM UMR 649, CHU Nantes, Faculte de Medecine, Universite de Nantes, Nantes, France
    Mol Ther 16:1291-9. 2008
    ..However, regardless of the mode of delivery, concerns continue to be raised by the presence of vector sequences detected at distant sites...
  88. ncbi Mapping of architectonic subdivisions in the macaque monkey, with emphasis on parieto-occipital cortex
    J W Lewis
    California Institute of Technology, Pasadena, California 16825, USA
    J Comp Neurol 428:79-111. 2000
    ....
  89. ncbi Cortical connections of areas V3 and VP of macaque monkey extrastriate visual cortex
    D J Felleman
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    J Comp Neurol 379:21-47. 1997
    ..The convergence and divergence of pathways involving V3 and VP underscores the distributed nature of hierarchical processing in the visual system...
  90. ncbi The cortical visual area V6: brain location and visual topography
    C Galletti
    Dipartimento di Fisiologia Umana e Generale, Universita di Bologna, Piazza di Porta S Donato 2, 40127 Bologna, Italy
    Eur J Neurosci 11:3922-36. 1999
    ....
  91. pmc Intention and attention: different functional roles for LIPd and LIPv
    Yuqing Liu
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Neurosci 13:495-500. 2010
    ..Using our technique, we found a clear structure-function relationship that distinguishes LIPv from LIPd and found dissociable circuits for attention and eye movements in the posterior parietal cortex...
  92. ncbi Dysfunction of IL-10-producing type 1 regulatory T cells and CD4(+)CD25(+) regulatory T cells in a mimic model of human multiple sclerosis in Cynomolgus monkeys
    Anlun Ma
    Laboratory of Experimental Surgery, Research Centre, Center hospitalier de l Université de Montréal CHUM Hôpital Notre Dame, Montreal, Quebec, Canada
    Int Immunopharmacol 9:599-608. 2009
    ..Loss of regulatory function appears to be an important factor in the pathogenesis of MS. Hence, to develop new approaches for induction of Tregs in vivo may be beneficial for the clinical treatment in autoimmune diseases...
  93. ncbi Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice
    A Casu
    Division of Immunogenetics, Department of Pediatrics, Children s Hospital of Pittsburgh, Rangos Research Centre, Rm 6103, 3460 Fifth Avenue, Pittsburgh, PA 15213, USA
    Diabetologia 51:120-9. 2008
    ..The present study investigated and compared relevant gluco-metabolic parameters in pigs, monkeys and the pig-to-monkey islet transplantation model to gain insight into the potential clinical outcome of pig-to-human islet transplantation...
  94. ncbi Mechanisms of protection induced by attenuated simian immunodeficiency virus. I. Protection cannot be transferred with immune serum
    N Almond
    AIDS Collaborating Centre, National Institute for Biological Standards and Control, Potters Bar, Herts, UK
    J Gen Virol 78:1919-22. 1997
    ..This is the first time that serum has been transferred from animals known to be protected against superinfection...
  95. pmc Clinical and pathologic features of cynomolgus macaques (Macaca fascicularis) infected with aerosolized Yersinia pestis
    Roger Van Andel
    Lovelace Respiratory Research Institute, Albuquerque, NM, USA
    Comp Med 58:68-75. 2008
    ..pestis), the causative agent of plague. A recent symposium concluded that the cynomolgus macaque (Macaca fascicularis) plague model should be characterized more fully...
  96. pmc Allogeneic lymphocytes persist and traffic in feral MHC-matched mauritian cynomolgus macaques
    Justin M Greene
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 3:e2384. 2008
    ..Previous adoptive transfers in primates have failed as transferred cells are typically cleared within hours after transfer...
  97. pmc Reticulospinal neurons in the pontomedullary reticular formation of the monkey (Macaca fascicularis)
    S T Sakai
    Department of Psychology and Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
    Neuroscience 163:1158-70. 2009
    ..The present results define the origins of the reticulospinal system in the monkey and provide an important foundation for future investigations of the anatomy and physiology of this system in primates...
  98. ncbi Diclofenac hydroxylation in monkeys: efficiency, regioselectivity, and response to inhibitors
    Cuyue Tang
    Departments of Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Biochem Pharmacol 73:880-90. 2007
    ....
  99. ncbi Concentrations of isoflavones in macaques consuming standard laboratory monkey diet
    Fawn C Stroud
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
    J Am Assoc Lab Anim Sci 45:20-3. 2006
    ..These data argue for the use of soy-free diets in studies investigating estrogenic effects on physiologic or behavioral endpoints...
  100. pmc The thalamocortical projection systems in primate: an anatomical support for multisensory and sensorimotor interplay
    Céline Cappe
    Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    Cereb Cortex 19:2025-37. 2009
    ..Based on the divergent/convergent pattern of TC and corticothalamic projections, 4 distinct mechanisms of multisensory and sensorimotor interplay are proposed...
  101. ncbi Cotransplantation with MSCs improves engraftment of HSCs after autologous intra-bone marrow transplantation in nonhuman primates
    Shigeo Masuda
    Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi 329 0498, Japan
    Exp Hematol 37:1250-1257.e1. 2009
    ..Here, using nonhuman primates, we investigated the effects of cotransplantation with MSCs on the engraftment of HSCs after autologous intra-bone marrow transplantation...

Research Grants64

  1. Development of an Anti-PSGL-1 Antibody to Treat Crohn's Disease
    Scott A Rollins; Fiscal Year: 2011
    ..Selexys is proposing to conduct a PK pilot dose ranging study in cynomolgus monkey (Macaca fascicularis) to assess safety and PK of the anti-PSGL-1 antibody...
  2. The Immunogenetics of Macaques Used in Biodefense Research
    ALESSANDRO D SETTE; Fiscal Year: 2011
    Rhesus macaques (Macaca mulatta) and Cynomolgus macaques (Macaca fascicularis), are widely used as models of disease pathogenesis in humans and for evaluating vaccines and therapeutics against microbial pathogens, including emerging ..
  3. Myocardial passive stiffness: effect of aging.
    WILLIAM CORSON HUNTER; Fiscal Year: 2010
    ..By utilizing a primate model (Macaca fascicularis) - rather than a rodent model - the conclusions from this project will provide greater insight into human ..
  4. SIMIAN VACCINE EVALUATION UNIT (SVEU)
    Dave Anderson; Fiscal Year: 2011
    ..or other nonhuman primate species, such as pig-tail macaques (Macaca nemestrina), cynomolgus monkeys (Macaca fascicularis), African green monkeys (Cercocebus atys), or baboons may be requested. 2...
  5. SIMIAN VACCINE EVALUATION UNIT (SVEU)
    Phillip D Markham; Fiscal Year: 2011
    ..or other nonhuman primate species, such as pig-tail macaques (Macaca nemestrina), cynomolgus monkeys (Macaca fascicularis), African green monkeys (Cercocebus atys), or baboons may be requested. 2...
  6. SIMIAN VACCINE EVALUATION UNIT (SVEU)
    Phillip D Markham; Fiscal Year: 2010
    ..or other nonhuman primate species, such as pig-tail macaques (Macaca nemestrina), cynomolgus monkeys (Macaca fascicularis), African green monkeys (Cercocebus atys), or baboons may be requested. 2...
  7. SIMIAN VACCINE EVALUATION UNITS
    Mark Lewis; Fiscal Year: 2011
    ..or other nonhuman primate species, such as pig-tail macaques (Macaca nemestrina), cynomolgus monkeys (Macaca fascicularis), African green monkeys (Cercocebus atys), or baboons may be requested. 2...
  8. SIMIAN VACCINE EVALUATION UNITS
    Mark Lewis; Fiscal Year: 2010
    ..or other nonhuman primate species, such as pig-tail macaques (Macaca nemestrina), cynomolgus monkeys (Macaca fascicularis), African green monkeys (Cercocebus atys), or baboons may be requested. 2...
  9. Primate iPS lines using Retrovirus and TAT Protein Transduction
    COLIN EDWARD BISHOP; Fiscal Year: 2010
    ..We therefore propose to: (1) generate induced pluripotent stem cell lines (iPS) from the non-human primate, Macaca fascicularis (cynomolgus macaque) (2) To determine if M...
  10. An Experimental Investigation into Staging CTS Utilizing Portable Ultrasound...
    Kevin D Evans; Fiscal Year: 2011
    ..a clinical standard and it is important to trend the ultrasound data against these measures in the 8 macaca fascicularis that are moving from baseline to recovery of MMN...
  11. Macaque Model of Carpal Tunnel Syndrome: Effects of Force and Posture Exposures
    Carolyn M Sommerich; Fiscal Year: 2010
    ..Research design and methods: Macaca fascicularis monkeys will be trained to perform a repetitive pinching task for daily food rations...
  12. Conference Support: NHP Models of Aging
    Joseph Kemnitz; Fiscal Year: 2001
    ..murinus), marmosets (Callithrix jacchus), squirrel monkeys (Saimiri sciureus), cynomolgus monkeys (Macaca fascicularis), baboons (Papio hamadryas), and chimpanzees (Pan troglodytes)...
  13. ANTIPROGESTINS IN ENDOMETRIUM
    RONALD WIEHLE; Fiscal Year: 2000
    ..I of this proposed SBIR program to determine effects on the eutopic endometrium of cynomolgus monkeys (Macaca fascicularis)...
  14. NON-INVASIVE ASSESSMENT OF PERIODONTAL DISEASE ACTIVITY
    CHRISTINE NIEKRASH; Fiscal Year: 1990
    ..The cynomolgus monkey (Macaca fascicularis) will be used because this animal will predictably develop actively-destructive periodontal lesions ..
  15. DEVELOPMENT OF A VACCINE FOR HUMAN PERIODONTITIS
    ROY PAGE; Fiscal Year: 2001
    ..The Principal Investigator has shown that immunization of the nonhuman primate Macaca fascicularis, using a killed P...
  16. NEURON TRANSPLANT THERAPY: A MODEL OF PARKINSONISM
    MARK DUBACH; Fiscal Year: 1990
    ..We will apply a newly developed model that meets these requirements. Dopaminergic cells of Macaca fascicularis are destroyed by unilateral neurotoxin injections directly into the substantia nigra, resulting in a ..
  17. Antiprogestins in Cynomolgus Endometriosis
    RONALD WIEHLE; Fiscal Year: 2003
    ..of Phase I of this SBIR program to determine effects on the eutopic endometrium of cynomolgus monkeys (Macaca fascicularis) following short-term administration, of our lead compound, CDB-4124...
  18. VASCULAR/METABOLIC EFFECTS OF REPEAT WEIGHT LOSS/REGAIN
    DIETER KRAMSCH; Fiscal Year: 1992
    ..We, therefore, propose to study these issues in a closely related nonhuman primate model (Macaca fascicularis monkeys) comprising the following groups of animals: 1) normal control monkeys; 2) monkeys on a high ..
  19. Macaque Model and Gene Expression Profiling of SARS
    Michael Katze; Fiscal Year: 2009
    ..in fatal SARS cases is the respiratory tract, and of existing animal models, the cynomolgus macaque (Macaca fascicularis) best replicates the pulmonary pathogenesis associated with human SARS...
  20. PERIODONTAL MICROBIOTA ACQUISITION: MOTHER-INFANT STUDI
    JAYNE DELANEY; Fiscal Year: 1991
    ..of the R23 project on the acquisition of periodontal microorganisms in the newborn and maturing primate Macaca fascicularis, and our initial studies on mother-infant transmission of specific microorganisms know to be involved in ..
  21. ANTI-INFLAMMATORY THERAPIES NEUROTOXICALLY INDUCED PD
    Ole Isacson; Fiscal Year: 2004
    ..The progressive decline of dopamine (DA) terminals seen in idiopathic PD can be closely modeled in Macaca fascicularis by low-dose exposure to the mitochondrial toxin, MPTP, over nine to fourteen months...
  22. CLONING & BIOLOGIC FUNCTION OF LEUKOTOXIN
    Jeffrey Ebersole; Fiscal Year: 1991
    ..e. Macaca fascicularis) but not other mammalian species...
  23. Immunogenetic characterization of MHC molecules as a tool for biomedical research
    Alessandro Sette; Fiscal Year: 2007
    Rhesus macaques (Macaca mulatta) and Cynomolgus macaques (Macaca fascicularis), are widely used as models of disease pathogenesis in humans and for evaluating vaccines and therapeutics against microbial pathogens, including emerging ..
  24. DYSREGULATION OF CETP AND LPL IN THE DIABETIC CYNOMOLGUS
    John Bagdade; Fiscal Year: 1993
    ..with colleagues at the Bowman Gray Department of Comparative Medicine that a group of cynomolgus monkeys (Macaca fascicularis) with insulin-dependent diabetes mellitus have abnormalities in CET and core lipid composition that ..
  25. DRUG TREATMENT OF STENOSING PRIMATE ATHEROSCLEROSIS
    DIETER KRAMSCH; Fiscal Year: 1980
    The Macaca fascicularis (cynomolgus) monkey has been developed as an experimental model for the study of obstructive atherosclerosis...
  26. BIOEFFECTS OF PRENATAL ULTRASOUND EXPOSURE
    Alice Tarantal; Fiscal Year: 1993
    ..The proposed studies incorporate a nonhuman primate (Macaca fascicularis) as a model for the human and a commercial ultrasound unit (ATL, MK 600)...
  27. Ethanol effects on liver in self-administering primates
    Carol Cunningham; Fiscal Year: 2004
    ..Eleven Macaca fascicularis monkeys will be given free access to ethanol in drinking water for 1 year...
  28. 5 ALPHA-REDUCTASE IN THE PRIMATE EPIDIDYMIS
    MARY MAHONY; Fiscal Year: 1999
    ..The cynomolgus monkey (Macaca fascicularis), a nonhuman primate is the preferred animal model to study...
  29. GENE TRANSFER OF HUMAN ARGINASE
    Wayne Grody; Fiscal Year: 1990
    ..Transfer and expression of cloned arginase sequences from Macaca fascicularis, a primate species exhibiting a natural regulatory polymorphism for expression of AI in red blood cells, ..
  30. RISKS AND BENEFITS OF MODERATE ALCOHOL
    CAROL SHIVELY; Fiscal Year: 2000
    ..consumption on CHD, osteoporosis, and breast cancer risk in ovariectomized female cynomolgus monkeys (Macaca fascicularis), a useful animal model for each of these endpoints...
  31. DIETARY FAT/CHOLESTEROL AND LOW DENSITY LIPOPROTEIN
    Robert Nicolosi; Fiscal Year: 1992
    ..of nutrition intervention on low density lipoprotein (LDL) metabolism using a nonhuman primate model (Macaca fascicularis)...
  32. CONTROL OF GNRH GENE EXPRESSION IN THE BRAIN
    Robert Steiner; Fiscal Year: 1991
    ..physiological control of GnRH gene expression within individual neurons in the brain of the male macaque, Macaca fascicularis. We have plotted 4 major areas of investigation. The first concerns steroid hormone feedback...
  33. SOCIAL STATUS AND ATHEROSCLEROSIS IN FEMALES
    CAROL SHIVELY; Fiscal Year: 1991
    ..The proposed experiment requires 48 adult female cynomolgus macaques (Macaca fascicularis), fed an atherogenic diet and living in social groups of four animals each...
  34. CENTRAL CHOLINERGIC PATHWAYS
    Marek Marsel Mesulam; Fiscal Year: 1999
    ..Experiments will be conducted in Macaca fascicularis, surgically removed cortical tissue from epileptic patients, and post-mortem specimens from neurologically ..
  35. Primate Model for Pharmaceutical Development
    You Tang Shen; Fiscal Year: 2005
    ..of chronic catheters and transducers to measure cardiac and systemic hemodynamics in non-human primates (Macaca fascicularis) will be performed...
  36. GABA-A Receptors, Ethanol, and Stress in Monkey Amygdala
    BRIAN MCCOOL; Fiscal Year: 2006
    ..Preliminary studies in our laboratory have utilized acutely isolated amygdala neurons from control Macaca fascicularis monkeys and from monkeys that have self-administered ethanol for 18 months...
  37. VESTIBULAR AFFERENT ACTIVITY AFTER CANAL PLUGGING
    Sergei Yakushin; Fiscal Year: 2002
    ..This work should lead to a clearer understanding of how lesions, such as plugging and nerve section, affect the sensory processing of head movements and how the central vestibular system adapts to these types of lesions. ..
  38. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  39. Rhesus Embryonic Stem Cell-Derived Serotonin Neurons
    CYNTHIA BETHEA; Fiscal Year: 2007
    ..The knowledge obtained from this work will lead to novel treatments for psychoneuropathologies. [unreadable] [unreadable]..
  40. GM1 Ganglioside Effects on Parkinson's Disease
    Jay Schneider; Fiscal Year: 2007
    ..Working hypothesis: Long-term GM1 use will stabilize symptoms or slow the progression of symptoms in PD patients and this may be accompanied by reduced loss of striatal DA terminals over time. [unreadable] [unreadable]..
  41. Nicotine and Cognition in Parkinsonism
    Jay Schneider; Fiscal Year: 2008
    ..Information obtained from these studies will hopefully lead to more efficient design of nicotinic therapeutics for patients with a variety of cognitive disorders. ..
  42. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    JANICE WAGNER; Fiscal Year: 2006
    ..A concurrent P40 application is being submitted by WaNPRC, entitled "WaNPRC-WFUSM Macaca fascicularis SPF Breeding Colony"...
  43. Lamina I and Homeostasis
    Arthur Craig; Fiscal Year: 2005
    ..The fundamental knowledge will provide new opportunities for explaining maladaptive homeostatic responses to somatic physiological changes, including such human pathological conditions as fibromyalgia. ..
  44. Physiology of Lamina I and V STT Cells
    Arthur Craig; Fiscal Year: 2005
    ..This research will provide new insights into the synergy between lamina I and V STT neurons and into the integration underlying pain, temperature and itch sensations that is altered in clinical disorders. ..
  45. Areas of Amygdala and Frontal Cortex in Outcome Learning
    CHRISTA HELMS; Fiscal Year: 2006
    ..Understanding how these brain regions are involved in learning about rewards will provide information about the processes disrupted in drug abusers. ..
  46. Effects of Dietary Soy on Biomarkers in Prostate Cancer
    J Cline; Fiscal Year: 2004
    ..abstract_text> ..
  47. Information transfer through ganglion cells
    Barry Lee; Fiscal Year: 2010
    ..abstract_text> ..
  48. Fine Structure of Lamina I TSST Terminals in VP
    Arthur Craig; Fiscal Year: 2004
    ..These studies will advance our understanding of the anatomical substrates for pain sensation in the primate thalamus. ..
  49. Soy and Estrogen Interactions in the Breast
    J Cline; Fiscal Year: 2009
    ..The proposed work will provide a unique view of an otherwise inaccessible period of breast development in a primate model with high genetic and physiologic similarity to human beings. ..
  50. Molecular & Behavioral Effects of Low Level Mn Exposure
    TOMAS GUILARTE; Fiscal Year: 2008
    ..The knowledge gained will help set future public health policies and guidelines to limit Mn exposures in occupational settings and to the general population. ..
  51. Sensory-motor Integration in the Primate Cortex
    Michael Graziano; Fiscal Year: 2008
    ..The proposed research may also contribute to the development of limb prosthetics and artificial devices for object manipulation. ..
  52. PROSTAGLANDINS IN PRIMATE OVULATORY FOLLICLES
    DIANE DUFFY; Fiscal Year: 2003
    ..This may provide insight into the mechanisms leading to infertility (e.g., leuteinized unruptured follice syndrome) and support the developoment of PG synthesis inhibitors of PG synthesis inhibitors for use as contraceptives. ..
  53. DEVELOPMENTAL EFFECTS OF METHYLMERCURY
    THOMAS BURBACHER; Fiscal Year: 2002
    ..evaluation of the effects of in utero methylmercury (MeHg) exposure at different stages of the life span of Macaca fascicularis monkeys...
  54. The Role of Outer Retinal Injury in Glaucoma
    T Nork; Fiscal Year: 2004
    ..abstract_text> ..
  55. METHANOL EXPOSURE EFFECTS ON PRIMATE DEVELOPMENT
    THOMAS BURBACHER; Fiscal Year: 2001
    ....
  56. Atherosclerosis Stage, Estrogen Receptors, and Vascular Responses to Estrogen
    THOMAS COSTIN REGISTER; Fiscal Year: 2010
    ....
  57. Altered Inhibitory Prefrontal Circuitry in Schizophrenia
    DAVID VOLK; Fiscal Year: 2003
    ..After a 3 month survival period, we will quantify any changes in the mRNA expression of PFC GABA markers using in situ hybridization and grain counting techniques. ..
  58. SOY, LIFE STAGE, STRESS AND ATHEROSCLEROSIS IN FEMALES
    JAY KAPLAN; Fiscal Year: 2009
    ....
  59. OCULOMOTOR SYSTEM AND BODY POSTURAL MECHANISMS
    Bernard Cohen; Fiscal Year: 2009
    ..abstract_text> ..
  60. RETINAL ORGANIZATION OF COLOR PATHWAYS
    DAVID CALKINS; Fiscal Year: 2002
    ....
  61. REPRESENTATION OF SATIETY IN ORBITOFRONTAL CORTEX
    THOMAS PRITCHARD; Fiscal Year: 2003
    ..These data may expedite development of successful strategies for diagnosis and treatment of various eating and metabolic disorders. ..
  62. QUANTITATIVE STUDIES OF CORTICAL VISUAL PROCESSING
    DARIO RINGACH; Fiscal Year: 2009
    ....