macaca

Summary

Summary: A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of 16 species inhabiting forests of Africa, Asia, and the islands of Borneo, Philippines, and Celebes.

Top Publications

  1. ncbi Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques
    Ann J Hessell
    Department of Immunology and Microbial Science and International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, USA
    Nat Med 15:951-4. 2009
  2. pmc Network structure of cerebral cortex shapes functional connectivity on multiple time scales
    Christopher J Honey
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
    Proc Natl Acad Sci U S A 104:10240-5. 2007
  3. ncbi Supplementary eye field as defined by intracortical microstimulation: connections in macaques
    M F Huerta
    Department of BioStructure and Function, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    J Comp Neurol 293:299-330. 1990
  4. pmc Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates
    Carrie E McCurdy
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Clin Invest 119:323-35. 2009
  5. ncbi A large focus of naturally acquired Plasmodium knowlesi infections in human beings
    Balbir Singh
    Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kuching, Sarawak, Malaysia
    Lancet 363:1017-24. 2004
  6. pmc Adaptive evolution of young gene duplicates in mammals
    Mira V Han
    School of Informatics, Indiana University, Bloomington, IN 47405, USA
    Genome Res 19:859-67. 2009
  7. ncbi Theoretical neuroanatomy: relating anatomical and functional connectivity in graphs and cortical connection matrices
    O Sporns
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Cereb Cortex 10:127-41. 2000
  8. pmc A monkey's tale: the origin of Plasmodium vivax as a human malaria parasite
    Ananias A Escalante
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Chamblee, GA 30341, USA
    Proc Natl Acad Sci U S A 102:1980-5. 2005
  9. ncbi Neural correlates of decision variables in parietal cortex
    M L Platt
    Center for Neural Science, New York University, New York 10003, USA
    Nature 400:233-8. 1999
  10. ncbi Representation of action-specific reward values in the striatum
    Kazuyuki Samejima
    Department of Computational Neurobiology, ATR Computational Neuroscience Laboratories, 619 0288 Kyoto, Japan
    Science 310:1337-40. 2005

Detail Information

Publications328 found, 100 shown here

  1. ncbi Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques
    Ann J Hessell
    Department of Immunology and Microbial Science and International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, USA
    Nat Med 15:951-4. 2009
    ..Overall, the results imply that lower amounts of antibody than previously considered protective may provide benefit in the context of typical human exposure to HIV-1...
  2. pmc Network structure of cerebral cortex shapes functional connectivity on multiple time scales
    Christopher J Honey
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
    Proc Natl Acad Sci U S A 104:10240-5. 2007
    ....
  3. ncbi Supplementary eye field as defined by intracortical microstimulation: connections in macaques
    M F Huerta
    Department of BioStructure and Function, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    J Comp Neurol 293:299-330. 1990
    ..Such connectional differences suggest functional differences between these two sensorimotor regions of the frontal lobe...
  4. pmc Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates
    Carrie E McCurdy
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Clin Invest 119:323-35. 2009
    ..These results suggest that a developing fetus is highly vulnerable to excess lipids, independent of maternal diabetes and/or obesity, and that exposure to this may increase the risk of pediatric NAFLD...
  5. ncbi A large focus of naturally acquired Plasmodium knowlesi infections in human beings
    Balbir Singh
    Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kuching, Sarawak, Malaysia
    Lancet 363:1017-24. 2004
    ..We aimed to investigate whether such infections could be attributable to a variant form of P malariae or a newly emergent Plasmodium species...
  6. pmc Adaptive evolution of young gene duplicates in mammals
    Mira V Han
    School of Informatics, Indiana University, Bloomington, IN 47405, USA
    Genome Res 19:859-67. 2009
    ..The results are also in agreement with the classical model of evolution by gene duplication, supporting a common role for neofunctionalization in the long-term maintenance of gene duplicates...
  7. ncbi Theoretical neuroanatomy: relating anatomical and functional connectivity in graphs and cortical connection matrices
    O Sporns
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Cereb Cortex 10:127-41. 2000
    ..We hypothesize that adaptation to rich sensory environments and motor demands requires complex dynamics and that these dynamics are supported by neuroanatomical motifs that are characteristic of the cerebral cortex...
  8. pmc A monkey's tale: the origin of Plasmodium vivax as a human malaria parasite
    Ananias A Escalante
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Chamblee, GA 30341, USA
    Proc Natl Acad Sci U S A 102:1980-5. 2005
    ..vivax populations and the phylogeny of the genus Plasmodium...
  9. ncbi Neural correlates of decision variables in parietal cortex
    M L Platt
    Center for Neural Science, New York University, New York 10003, USA
    Nature 400:233-8. 1999
    ..Our data indicate that a decision-theoretic model may provide a powerful new framework for studying the neural processes that intervene between sensation and action...
  10. ncbi Representation of action-specific reward values in the striatum
    Kazuyuki Samejima
    Department of Computational Neurobiology, ATR Computational Neuroscience Laboratories, 619 0288 Kyoto, Japan
    Science 310:1337-40. 2005
    ..Fewer neurons were tuned to relative values or action choice. These results suggest representation of action values in the striatum, which can guide action selection in the basal ganglia circuit...
  11. ncbi An RNA gene expressed during cortical development evolved rapidly in humans
    Katherine S Pollard
    Center for Biomolecular Science and Engineering, Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95064, USA
    Nature 443:167-72. 2006
    ..HAR1 and the other human accelerated regions provide new candidates in the search for uniquely human biology...
  12. pmc Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro
    P W Parren
    Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 75:8340-7. 2001
    ..The significance of such substerilizing neutralizing antibody titers in the context of a potent cellular immune response is an important area for further study...
  13. pmc Dynamic social adaptation of motion-related neurons in primate parietal cortex
    Naotaka Fujii
    Laboratory for Symbolic Cognitive Development, RIKEN Brain Science Institute, Wako, Japan
    PLoS ONE 2:e397. 2007
    ..Our results suggest that parietal neurons can recognize social events in the environment linked with current social context and form part of a larger social brain network...
  14. ncbi Differential roles of monkey striatum in learning of sequential hand movement
    S Miyachi
    Laboratory of Neural Control, National Institute for Physiological Sciences, Okazaki, Japan
    Exp Brain Res 115:1-5. 1997
    ..These results suggest that the anterior and posterior portions of the striatum participate in different aspects of learning of sequential movements...
  15. ncbi Organization of corticostriatal motor inputs in monkey putamen
    Atsushi Nambu
    Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    J Neurophysiol 88:1830-42. 2002
    ..parts of the forelimb representation of the MI and in the forelimb representation of the SMA in Japanese monkeys (Macaca fuscata)...
  16. ncbi Humans and macaques employ similar face-processing strategies
    Christoph D Dahl
    Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, 72076 Tubingen, Germany
    Curr Biol 19:509-13. 2009
    ..These findings therefore directly contribute to one of the central discussions in the behavioral and neurosciences about how faces are perceived in primates...
  17. pmc Video-induced yawning in stumptail macaques (Macaca arctoides)
    Annika Paukner
    Department of Psychology, University of Stirling, Stirling, FK9 4LA, UK
    Biol Lett 2:36-8. 2006
    ..Twenty-two stumptail macaques (Macaca arctoides) were presented with video clips of either yawns or control mouth movements by conspecifics...
  18. ncbi Comparison of spatial integration and surround suppression characteristics in spiking activity and the local field potential in macaque V1
    M A Gieselmann
    Institute of Neuroscience, Henry Wellcome Building, Framlington Place Newcastle University, Newcastle upon Tyne, UK
    Eur J Neurosci 28:447-59. 2008
    ..Thus, suppressive influences in primary cortex can be inferred from spiking activity, but they also seem to affect specific features of gamma-band LFP activity...
  19. ncbi Shared mapping of own and others' bodies in visuotactile bimodal area of monkey parietal cortex
    Hiroaki Ishida
    Kinki University, Osaka Sayama, Japan
    J Cogn Neurosci 22:83-96. 2010
    ..These neurons may contribute to spatial matching between the bodies of the self and others in both action recognition and imitation...
  20. pmc Maternal high-fat diet disturbs uteroplacental hemodynamics and increases the frequency of stillbirth in a nonhuman primate model of excess nutrition
    Antonio E Frias
    Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Endocrinology 152:2456-64. 2011
    ..These results suggest that a HFD, independent of obesity, decreases uterine volume blood flow. Maternal obesity and insulin resistance further exacerbates the placental dysfunction and results in an increased frequency of stillbirth...
  21. ncbi Intrinsic Connections in the macaque inferior temporal cortex
    I Fujita
    Precursory Research for Embryonic Science and Technology PRESTO, Research Development Corporation of Japan, Japan
    J Comp Neurol 368:467-86. 1996
    ..Vertical connections across layers and cylindrical patches of horizontal axons most likely contribute to the shared stimulus selectivity among cells within a column...
  22. ncbi Cortical connections of the anterior (F5a) subdivision of the macaque ventral premotor area F5
    Marzio Gerbella
    Dipartimento di Neuroscienze, Sezione di Fisiologia, Universita di Parma, Via Volturno 39, 43100 Parma, Italy
    Brain Struct Funct 216:43-65. 2011
    ..The results of this integration can be then broadcasted to the adjacent F5 sectors for the generation and control of hand actions and cognitive motor functions...
  23. ncbi Functional brain mapping of monkey tool use
    S Obayashi
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, CREST JST, Chiba 263 8555, Japan
    Neuroimage 14:853-61. 2001
    ..These tool use-specific areas may participate in maintaining and updating the body-image for the precise guidance of a hand-held rake onto a distant reward...
  24. ncbi The prefrontal cortex and cognitive control
    E K Miller
    Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Rev Neurosci 1:59-65. 2000
    ..Studies indicate that the prefrontal cortex is central in this process. It provides an infrastructure for synthesizing a diverse range of information that lays the foundation for the complex forms of behaviour observed in primates...
  25. pmc Human-specific transcriptional networks in the brain
    Genevieve Konopka
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Neuron 75:601-17. 2012
    ..These data demonstrate that transcriptional networks have undergone evolutionary remodeling even within a given brain region, providing a window through which to view the foundation of uniquely human cognitive capacities...
  26. ncbi Differential activation of monkey striatal neurons in the early and late stages of procedural learning
    Shigehiro Miyachi
    Department of Physiology, Juntendo University, School of Medicine, Tokyo, Japan
    Exp Brain Res 146:122-6. 2002
    ....
  27. pmc Nonoptimal component placement, but short processing paths, due to long-distance projections in neural systems
    Marcus Kaiser
    School of Computing Science, University of Newcastle, Newcastle upon Tyne, United Kingdom
    PLoS Comput Biol 2:e95. 2006
    ..These findings suggest that neural systems are not exclusively optimized for minimal global wiring, but for a variety of factors including the minimization of processing steps...
  28. ncbi The role of feedback in shaping the extra-classical receptive field of cortical neurons: a recurrent network model
    Lars Schwabe
    Fakultät IV, Electrical Engineering and Computer Science, Technische Universitat Berlin, 10587 Berlin, Germany
    J Neurosci 26:9117-29. 2006
    ..Our model provides a general mechanism of how top-down feedback signals directly contribute to generating cortical neuron responses to simple sensory stimuli...
  29. ncbi Functional connectivity between anatomically unconnected areas is shaped by collective network-level effects in the macaque cortex
    Yusuke Adachi
    Department of Physiology, The University of Tokyo School of Medicine, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Cereb Cortex 22:1586-92. 2012
    ..Our findings indicate that FC is not determined solely by interareal short connection patterns but instead is substantially influenced by the network-level cortical architecture...
  30. pmc Adoption of an "open" envelope conformation facilitating CD4 binding and structural remodeling precedes coreceptor switch in R5 SHIV-infected macaques
    Ke Zhuang
    Aaron Diamond AIDS Research Center, New York, New York, United States of America
    PLoS ONE 6:e21350. 2011
    ..These observations in a simian model of R5-to-X4 evolution provide a mechanistic basis for the HIV-1 coreceptor switch...
  31. pmc Efficacy of Carraguard-based microbicides in vivo despite variable in vitro activity
    Stuart G Turville
    Center for Biomedical Research, HIV and AIDS Program, Population Council, New York, New York, United States of America
    PLoS ONE 3:e3162. 2008
    ..This work also underscores the potential of Carraguard-based formulations for the delivery of anti-viral drugs to prevent vaginal HIV infection...
  32. ncbi Increase in dephosphorylation of the heavy neurofilament subunit in the monkey chronic glaucoma model
    Kenji Kashiwagi
    Department of Ophthalmology, Yamanashi Medical University, 1110 Shimokato, Tamaho, Yamanashi 409 3898, Japan
    Invest Ophthalmol Vis Sci 44:154-9. 2003
    ....
  33. ncbi Dominance, aggression and physiological stress in wild male Assamese macaques (Macaca assamensis)
    Julia Ostner
    Integrative Primate Socio Ecology, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Horm Behav 54:613-9. 2008
    ..such as reproductive season, age and amount of aggression received in wild, seasonally breeding Assamese macaques (Macaca assamensis)...
  34. ncbi Architectonic identification of the core region in auditory cortex of macaques, chimpanzees, and humans
    T A Hackett
    Department of Hearing and Speech Sciences, Vanderbilt University, 301 Wilson Hall, 111 21st Avenue South, Nashville, TN 37203, USA
    J Comp Neurol 441:197-222. 2001
    ..study was to determine whether the architectonic criteria used to identify the core region in macaque monkeys (Macaca mulatta, M...
  35. ncbi Tools for the body (schema)
    Angelo Maravita
    Dipartimento di Psicologia, Universita di Milano Bicocca, Piazza dell Ateneo Nuovo 1, 20126 Milan, Italy
    Trends Cogn Sci 8:79-86. 2004
    ..These relatively simple neural and behavioural aspects of tool-use shed light on more complex evolutionary and cognitive aspects of body representation and multisensory space coding for action...
  36. ncbi Representation of objective similarity among three-dimensional shapes in the monkey
    T Sugihara
    Department of Biochemical Engineering and Science, Kyushu Institute Technology, Fukuoka, Japan
    Biol Cybern 78:1-7. 1998
    ..A monkey (Macaca fuscata) performed a delayed matching-to-sample task with 28 images (4 views x 7 objects)...
  37. pmc Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet
    B E Grayson
    Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Endocrinology 151:1622-32. 2010
    ..Indeed, the HFD offspring develop early-onset excess weight gain. These abnormalities may be prevented by healthful nutrient consumption during pregnancy even in obese and severely insulin-resistant individuals...
  38. ncbi Social bonds enhance reproductive success in male macaques
    Oliver Schülke
    Courant Research Centre Evolution of Social Behaviour, Georg August University, Gottingen, 37077 Gottingen, Germany
    Curr Biol 20:2207-10. 2010
    ..We studied social bonds among dispersing male Assamese macaques (Macaca assamensis) to see whether males in multimale groups form differentiated social bonds and whether and how males ..
  39. ncbi A simple white noise analysis of neuronal light responses
    E J Chichilnisky
    Systems Neurobiology, The Salk Institute, La Jolla, CA 92037 1099, USA
    Network 12:199-213. 2001
    ..Advantages and disadvantages of the technique relative to classical approaches are discussed...
  40. ncbi Fission-fusion dynamics, behavioral flexibility, and inhibitory control in primates
    Federica Amici
    Research Centre in Evolutionary Anthropology and Palaeoecology, School of Biological and Earth Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, United Kingdom
    Curr Biol 18:1415-9. 2008
    ..These findings confirmed that enhanced inhibitory skills are positively associated with FF dynamics, more than to phylogenetic relations or feeding ecology...
  41. pmc Transfer of neutralizing IgG to macaques 6 h but not 24 h after SHIV infection confers sterilizing protection: implications for HIV-1 vaccine development
    Yoshiaki Nishimura
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:15131-6. 2003
    ....
  42. pmc Different tempo and anatomic location of dual-tropic and X4 virus emergence in a model of R5 simian-human immunodeficiency virus infection
    Wuze Ren
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    J Virol 84:340-51. 2010
    ..These findings help define R5 SHIV(SF162P3N) infection of rhesus macaques as a model to study the mechanistic basis, dynamics, and sites of HIV-1 coreceptor switch...
  43. pmc Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates
    Melissa Suter
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA
    FASEB J 25:714-26. 2011
    ..In summary, the data suggest that peripheral Npas2 expression is uniquely vulnerable to diet exposure...
  44. pmc Topically applied recombinant chemokine analogues fully protect macaques from vaginal simian-human immunodeficiency virus challenge
    Ronald S Veazey
    Tulane National Primate Research Center, Covington, Louisiana, USA
    J Infect Dis 199:1525-7. 2009
    ..These highly potent molecules, which are amenable to low-cost production, represent promising new additions to the microbicides pipeline...
  45. pmc Functional organization of color domains in V1 and V2 of macaque monkey revealed by optical imaging
    Haidong D Lu
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    Cereb Cortex 18:516-33. 2008
    ..We conclude that color and orientation-selective responses are preferentially located in distinct CO compartments in V1 and V2. We propose that the term "blob" encompasses both the concept of "CO blob" and "color domain" in V1...
  46. ncbi Organization of inputs from cingulate motor areas to basal ganglia in macaque monkey
    M Takada
    Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
    Eur J Neurosci 14:1633-50. 2001
    ..The present results indicate that a parallel design underlies motor information processing in the cortico-basal ganglia loop derived from the rostral and caudal cingulate motor areas...
  47. pmc Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel
    Martin Cranage
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s University of London, London, United Kingdom
    PLoS Med 5:e157; discussion e157. 2008
    ....
  48. ncbi Dissociable components of rule-guided behavior depend on distinct medial and prefrontal regions
    Mark J Buckley
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK
    Science 325:52-8. 2009
    ....
  49. pmc Global optimization of cerebral cortex layout
    Christopher Cherniak
    Committee for Philosophy and the Sciences, Department of Philosophy, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 101:1081-6. 2004
    ..S. states. However, cortex wiring conforms to the size law better than the macroeconomic patterns, which may indicate cortex optimizing mechanisms involve more global processes...
  50. ncbi Numerical representation for action in the parietal cortex of the monkey
    Hiromasa Sawamura
    Department of Physiology, Tohoku University School of Medicine, Sendai 980, Japan
    Nature 415:918-22. 2002
    ..Such activity in the superior parietal lobule is useful for processing numerical information, which is necessary to provide a foundation for the forthcoming motor selection...
  51. ncbi Spatial integration and its moderation by attention and acetylcholine
    Mark J Roberts
    Institute of Neuroscience, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Front Biosci 13:3742-59. 2008
    ..These data demonstrate that attention can alter perceptual and neuronal spatial integration, and that acetylcholine might contribute to task dependent receptive field dynamics...
  52. pmc Phylogeny of the macaques (Cercopithecidae: Macaca) based on Alu elements
    Jing Li
    Department of Biological Sciences, Louisiana State University, 202 Life Sciences Building, Baton Rouge, Louisiana 70803, USA
    Gene 448:242-9. 2009
    Genus Macaca (Cercopithecidae: Papionini) is one of the most successful primate radiations...
  53. ncbi Fireworks in the primate retina: in vitro photodynamics reveals diverse LGN-projecting ganglion cell types
    Dennis M Dacey
    Department of Biological Structure, University of Washington, Seattle, WA 98175, USA
    Neuron 37:15-27. 2003
    ..Cells could also be targeted in vitro for intracellular recording and physiological analysis. The photodynamic process was also observed in pyramidal cells in a rat neocortical slice...
  54. ncbi Spatiotemporal elements of macaque v1 receptive fields
    Nicole C Rust
    Center for Neural Science and New York University, New York, New York 10003, USA
    Neuron 46:945-56. 2005
    ..Suppressive signals are especially potent in direction-selective cells, where they reduce responses to stimuli moving in the nonpreferred direction...
  55. ncbi Higher order visual processing in macaque extrastriate cortex
    Guy A Orban
    Laboratorium voor Neuro en Psychofysiologie, K U Leuven Medical School, Leuven, Belgium
    Physiol Rev 88:59-89. 2008
    ..The most common putative mechanism for generating such emergent selectivity is the pattern of excitatory and inhibitory linear inputs from the afferent area combined with nonlinear mechanisms in the afferent and receiving area...
  56. pmc Anatomical connectivity defines the organization of clusters of cortical areas in the macaque monkey and the cat
    C C Hilgetag
    Department of Psychology, University of Newcastle upon Tyne, UK
    Philos Trans R Soc Lond B Biol Sci 355:91-110. 2000
    ..These clusters reflected functionally specialized sets of cortical areas, suggesting that structure and function are closely linked at this gross, systems level...
  57. ncbi Influence of reward expectation on visuospatial processing in macaque lateral prefrontal cortex
    Shunsuke Kobayashi
    Department of Neurology, University of Tokyo School of Medicine, Tokyo 113 8655, Japan
    J Neurophysiol 87:1488-98. 2002
    ....
  58. pmc Transcriptionally abundant major histocompatibility complex class I alleles are fundamental to nonhuman primate simian immunodeficiency virus-specific CD8+ T cell responses
    Melisa L Budde
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Virol 85:3250-61. 2011
    ..Thus, only a subset of the thousands of known MHC-I alleles in macaques should be prioritized for CD8(+) T cell epitope characterization...
  59. pmc A simian immunodeficiency virus macaque model of highly active antiretroviral treatment: viral latency in the periphery and the central nervous system
    Janice E Clements
    Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Curr Opin HIV AIDS 6:37-42. 2011
    ....
  60. pmc Neuronal responses to texture-defined form in macaque visual area V2
    Yasmine El-Shamayleh
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 31:8543-55. 2011
    ..family of texture patterns to measure the selectivity of neurons in extrastriate cortical area V2 of the macaque (Macaca nemestrina, Macaca fascicularis) for the orientation of texture-defined form, and to distinguish responses to ..
  61. ncbi View-based encoding of actions in mirror neurons of area f5 in macaque premotor cortex
    Vittorio Caggiano
    Department of Cognitive Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, 72076 Tubingen, Germany
    Curr Biol 21:144-8. 2011
    ....
  62. pmc Monkeys monitor human goals in a nonmatch-to-goal interactive task
    Rossella Falcone
    Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy
    PLoS ONE 7:e32209. 2012
    ..They showed also a surprising ability to coordinate their actions, taking turns with the human partner, starting and stopping their own turn following the decision of the human partner in the task...
  63. ncbi Personality traits in captive lion-tailed macaques (Macaca silenus)
    Jacqueline H Rouff
    Department of Anthropology, Washington University in St Louis, MO 63038, USA
    Am J Primatol 67:177-98. 2005
    ....
  64. ncbi Roles of the primate motor thalamus in the generation of antisaccades
    Jun Kunimatsu
    Department of Physiology, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 30:5108-17. 2010
    ..The neuronal processes through the thalamocortical pathways might be essential for the volitional control of saccades...
  65. ncbi Circuitry and the classification of simple and complex cells in V1
    Jim Wielaard
    Laboratory for Intelligent Imaging and Neural Computing, Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, NY 10027, USA
    J Neurophysiol 96:2739-49. 2006
    ..Further, the distribution of this measure is qualitatively similar to that of the subfield correlation coefficient, although it is more robust and easier to obtain experimentally...
  66. ncbi Host age, sex, and reproductive seasonality affect nematode parasitism in wild Japanese macaques
    Andrew J J MacIntosh
    Department of Ecology and Social Behavior, Kyoto University Primate Research Institute, Inuyama, Aichi, Japan
    Primates 51:353-64. 2010
    ..over an annual cycle on the eggs per gram of feces (EPG) of nematode parasites infecting wild Japanese macaques (Macaca fuscata yakui) on Yakushima Island...
  67. ncbi Direct comparison of spontaneous functional connectivity and effective connectivity measured by intracortical microstimulation: an fMRI study in macaque monkeys
    Teppei Matsui
    Department of Physiology, The University of Tokyo School of Medicine, Tokyo, Japan
    Cereb Cortex 21:2348-56. 2011
    ..Our results suggest that intrahemispheric inFC reflects the efficacy of causal interactions, whereas interhemispheric inFC may arise from interactions akin to network-level synchronization that is not captured by emEC...
  68. pmc Antigen-specific Vgamma2Vdelta2 T effector cells confer homeostatic protection against pneumonic plaque lesions
    Dan Huang
    Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 106:7553-8. 2009
    ..The findings are consist with the paradigm that circulating Vgamma2Vdelta2 T cells can traffic to lungs for homeostatic protection against tissue damages in infection...
  69. ncbi Phase-of-firing coding of natural visual stimuli in primary visual cortex
    Marcelo A Montemurro
    Faculty of Life Sciences, University of Manchester, The Mill, PO Box 88, Manchester M60 1QD, United Kingdom
    Curr Biol 18:375-80. 2008
    ..Thus, phase coding may allow primary cortical neurons to represent several effective stimuli in an easily decodable format...
  70. ncbi Self-images in the video monitor coded by monkey intraparietal neurons
    A Iriki
    Section of Cognitive Neurobiology, Department of Maxillofacial Biology, Tokyo Medical and Dental University, 113 8549, Tokyo, Japan
    Neurosci Res 40:163-73. 2001
    ..Further, the coding of the imaged hand could intentionally be altered to match the image artificially modified in the monitor...
  71. pmc Second order dimensionality reduction using minimum and maximum mutual information models
    Jeffrey D Fitzgerald
    Computational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America
    PLoS Comput Biol 7:e1002249. 2011
    ..With non-Gaussian stimuli, the minimum and maximum information methods significantly outperform STC in all cases, whereas MID performs best in the regime of low dimensional feature spaces...
  72. pmc Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems
    Jason E McDermott
    Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, Washington, USA
    BMC Syst Biol 5:190. 2011
    ..Each of these systems has been studied extensively in isolation, but little effort has been directed toward systematically characterizing the conservation of host response on a global level beyond known immune signaling cascades...
  73. pmc Neurons in primary motor cortex engaged during action observation
    Juliana Dushanova
    Department of Neuroscience, Brown University, Providence, RI 02906, USA
    Eur J Neurosci 31:386-98. 2010
    ....
  74. ncbi Reconstruction of movement-related intracortical activity from micro-electrocorticogram array signals in monkey primary motor cortex
    Hidenori Watanabe
    Division of Behavioral Development, Department of Developmental Physiology, National Institute for Physiological Sciences, Aichi, Japan
    J Neural Eng 9:036006. 2012
    ..55 ± 0.04. A time-frequency analysis of the reconstructed LFP showed clear transition between resting and movements by the monkey. These methods would be a powerful tool with wide-ranging applicability in neuroscience studies...
  75. ncbi Hundreds of brain maps in one atlas: registering coordinate-independent primate neuro-anatomical data to a standard brain
    Gleb Bezgin
    Rotman Research Institute of Baycrest Centre, University of Toronto, Toronto, Ontario, Canada
    Neuroimage 62:67-76. 2012
    ..Availability of deformation tools and homology evidence then allow one to directly attribute detailed anatomical animal data to human experimental results...
  76. ncbi Behavioral and emotional response of Japanese macaque (Macaca fuscata) mothers after their offspring receive an aggression
    Gabriele Schino
    Istituto di Scienze e Tecnologie della Cognizione, Consiglio Nazionale delle Ricerche, Rome, Italy
    J Comp Psychol 118:340-6. 2004
    The authors of this study investigated the behavioral and emotional response of female Japanese macaques (Macaca fuscata) to an aggression received by their offspring to evaluate the existence of cognitive empathic responses in a ..
  77. ncbi Age-related differences in social grooming among adult female Japanese monkeys ( Macaca fuscata)
    Masayuki Nakamichi
    Laboratory of Ethological Studies, Faculty of Human Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    Primates 44:239-46. 2003
    ..on age-related differences in social grooming among adult females in a free-ranging group of Japanese monkeys ( Macaca fuscata)...
  78. ncbi Reciprocation and interchange in wild Japanese macaques: grooming, cofeeding, and agonistic support
    Raffaella Ventura
    Scottish Primate Research Group, Division of Psychology, School of Social and Health Sciences, University of Abertay Dundee, Dundee, Scotland, United Kingdom
    Am J Primatol 68:1138-49. 2006
    ..This conclusion is supported by the fact that in various primate species animals tend to prefer high-ranking individuals as grooming partners...
  79. ncbi Proliferative enteritis associated with Lawsonia intracellularis in a Japanese macaque (Macaca fuscata)
    Maud Lafortune
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610 0126, USA
    J Zoo Wildl Med 35:549-52. 2004
    A 2.5-yr-old, intact male Japanese macaque (Macaca fuscata) was observed to have a thickened ileum during exploratory laparotomy...
  80. pmc Tickborne encephalitis in naturally exposed monkey (Macaca sylvanus)
    Jochen Süss
    Friedrich Loeffler Institute, Jena, Germany
    Emerg Infect Dis 13:905-7. 2007
    We describe tickborne encephalitis (TBE) in a monkey (Macaca sylvanus) after natural exposure in an area at risk for TBE...
  81. ncbi Patterns of anogenital swelling size and their endocrine correlates during ovulatory cycles and early pregnancy in free-ranging barbary macaques (Macaca sylvanus) of Gibraltar
    U Möhle
    Department of Reproductive Biology, German Primate Centre, Goettingen, Germany
    Am J Primatol 66:351-68. 2005
    ..The data provide a solid basis for further studies to explore sociosexual behavioral patterns and the functional significance of AS in this species...
  82. ncbi Encoding of social state information by neuronal activities in the macaque caudate nucleus
    Gustavo S Santos
    Laboratory for Integrated Theoretical Neuroscience, RIKEN BSI, Wako, Japan
    Soc Neurosci 7:42-58. 2012
    ..These results indicate that different neuronal activities in the CN encode social state information and reward-related information, which may contribute to adjusting competitive behavior in dynamic social contexts...
  83. ncbi Role of progesterone in nonhuman primate implantation
    Ov Daniel Slayden
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Semin Reprod Med 25:418-30. 2007
    ..We propose that nonhuman primates, especially macaques, can provide a valuable animal model for experimentally testing the functional role of P-regulated genes on endometrial receptivity...
  84. ncbi Activity in the lateral prefrontal cortex reflects multiple steps of future events in action plans
    Hajime Mushiake
    Department of Physiology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Neuron 50:631-41. 2006
    ..Our data suggest that the PFC is involved primarily in planning multiple future events that occur as a consequence of behavioral actions...
  85. ncbi Prediction of arm trajectory from the neural activities of the primary motor cortex with modular connectionist architecture
    Kyuwan Choi
    ATR Computational Neuroscience Laboratories, Keihanna Science City, Kyoto, Japan
    Neural Netw 22:1214-23. 2009
    ..As a result, the gating network switched the modules properly, and the accuracy of the estimated angles improved compared to the case of using only one artificial neural network...
  86. ncbi Dexterous finger movements in primate without monosynaptic corticomotoneuronal excitation
    Shigeto Sasaki
    Tokyo Metropolitan Institute for Neurosciencs, Tokyo, 183 8526, Japan
    J Neurophysiol 92:3142-7. 2004
    ..Precision grip and IFMs were observed already after 1-28 days postoperatively. Weakness in force and deficits in preshaping remained for an observation period of 3 mo. Indirect CM pathways may be important for neuro-rehabilitation...
  87. ncbi Influences of rewarding and aversive outcomes on activity in macaque lateral prefrontal cortex
    Shunsuke Kobayashi
    Brain Science Research Center, Tamagawa University Research Institute, Machida, Tokyo 194 0041, Japan
    Neuron 51:861-70. 2006
    ..Our results demonstrate that information about positive and negative reinforcers is processed differentially in prefrontal cortex, which could contribute to the role of this structure in goal-directed behavior...
  88. ncbi Rule-dependent shifting of sensorimotor representation in the primate prefrontal cortex
    Ken Ichi Amemori
    Laboratory of Cognitive Neurobiology, Hokkaido University Graduate School of Medicine, N15W7, Kita ku, Sapporo 060 8638, Japan
    Eur J Neurosci 23:1895-909. 2006
    ..These results suggest that a subset of mnemonic neurons in the lateral prefrontal cortex change their activity depending on a behavioural rule to guide a prospective motor command...
  89. ncbi Face processing limitation to own species in primates: a comparative study in brown capuchins, Tonkean macaques and humans
    Valerie Dufour
    CEPE, UPR 9010, CNRS, 7 rue de l Universite, 67000 Strasbourg, France
    Behav Processes 73:107-13. 2006
    ..We investigated face processing in one Old World species (genus Macaca) and in one New World species (genus Cebus)...
  90. pmc The statistical neuroanatomy of frontal networks in the macaque
    Bruno B Averbeck
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom
    PLoS Comput Biol 4:e1000050. 2008
    ....
  91. ncbi Anatomical origins of the classical receptive field and modulatory surround field of single neurons in macaque visual cortical area V1
    Alessandra Angelucci
    Department of Ophthalmology and Visual Science, Moran Eye Center, University of Utah, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    Prog Brain Res 136:373-88. 2002
    ....
  92. pmc The prefrontal cortex and the executive control of attention
    Andrew F Rossi
    Division of Neuroscience and Basic Behavioral Science, NIMH, NIH, Bethesda, MD 20892, USA
    Exp Brain Res 192:489-97. 2009
    ..The PFC in particular plays a critical role in the ability to switch attentional control on the basis of changing task demands...
  93. pmc Theta-activity in anterior cingulate cortex predicts task rules and their adjustments following errors
    Thilo Womelsdorf
    Department of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5K8, Canada
    Proc Natl Acad Sci U S A 107:5248-53. 2010
    ....
  94. ncbi The anatomical basis of functional localization in the cortex
    Richard E Passingham
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
    Nat Rev Neurosci 3:606-16. 2002
  95. pmc Mucosal immunization of cynomolgus macaques with the VSVDeltaG/ZEBOVGP vaccine stimulates strong ebola GP-specific immune responses
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS ONE 4:e5547. 2009
    ..Zaire ebolavirus (ZEBOV) produces a lethal viral hemorrhagic fever in humans and non-human primates...
  96. pmc Activity of pursuit-related neurons in medial superior temporal area (MST) during static roll-tilt
    Keishi Fujiwara
    Department of Physiology, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Cereb Cortex 21:155-65. 2011
    ..These results suggest that smooth pursuit and/or visual motion signals of MST neurons are not coded in the earth-centered coordinates; our results favor the head- and/or trunk-centered coordinates...
  97. ncbi A review on the inferior temporal cortex of the macaque
    Tamas Tompa
    Department of Physiology, Faculty of Medicine, University of Szeged, H 6720, Szeged, Dom ter 10, Hungary
    Brain Res Rev 62:165-82. 2010
    ..In this review, we try to integrate knowledge about the ITC to the changing view about the brain while outlining the work that has been done in the last decade...
  98. ncbi Default mode of brain activity demonstrated by positron emission tomography imaging in awake monkeys: higher rest-related than working memory-related activity in medial cortical areas
    Takashi Kojima
    Department of Psychology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, 183 8526, Japan
    J Neurosci 29:14463-71. 2009
    ....
  99. ncbi Connections between anterior inferotemporal cortex and superior temporal sulcus regions in the macaque monkey
    K S Saleem
    RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 20:5083-101. 2000
    ..It is also suggested that the information processing in the ventral bank of the rostral STS is distinct from that in TEad, and the former more directly interacts with TEav than TEad...
  100. ncbi Activity of pursuit neurons in the caudal part of the frontal eye fields during static roll-tilt
    Sergei A Kurkin
    Department of Physiology, Hokkaido University School of Medicine, West 7, North 15, Sapporo, 060 8638, Japan
    Exp Brain Res 176:658-64. 2007
    ..These results suggest that FEF pursuit neurons do not signal static roll-tilt and that they code pursuit signals in head/trunk-centered coordinates...
  101. pmc A macaque model to study vaginal HSV-2/immunodeficiency virus co-infection and the impact of HSV-2 on microbicide efficacy
    Federica Crostarosa
    Center for Biomedical Research, Population Council, New York, New York, United States of America
    PLoS ONE 4:e8060. 2009
    ..An animal model to investigate the underlying causes of the synergistic action of the two viruses and where preventative strategies can be tested under such complex physiological conditions is currently unavailable...

Research Grants67

  1. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  2. RNA interference therapy for Huntington's disease: studies in non-human primates
    Beverly L Davidson; Fiscal Year: 2010
    ..With these tools we can now answer the questions posed in a more relevant model, the normal NHP (rhesus macaque;Macaca mullata)...
  3. Response of Rhesus Sperm to Freezing: Recovery from Osmotic and Oxidative Stress
    Stuart A Meyers; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Efficient preservation of genetic resources of the rhesus monkey (Macaca mulatta) is critical to the mission of the National Center for Research Resources...
  4. Physiology and structure of prefrontal projections to memory and motor circuits
    Maria Medalla; Fiscal Year: 2013
    ..recording and intracellular filling of retrogradely-labeled neurons in slices prepared from adult rhesus monkeys (Macaca mulatta)...
  5. Simianizing hepatitis C: Defining the species-tropism of a hepatotropic virus
    Charles M Rice; Fiscal Year: 2013
    ..As a host species, we will initially focus on Rhesus macaques (Macaca mulatta) - monkeys that can be bred in captivity, have sufficient available research tools, are readily obtainable,..
  6. Optimized Adaptation of Simian-tropic R5 HIV Clade C to Pig-tailed Macaques
    RUTH MARGRIT RUPRECHT; Fiscal Year: 2013
    ..HIV-1 vpu, tat, rev and env has yielded pathogenic models in rhesus macaques (RMs) or pig-tailed macaques (PMs~ Macaca nemestrina)...
  7. Development of an Anti-PSGL-1 Antibody to Treat Crohn's Disease
    Scott A Rollins; Fiscal Year: 2011
    ..Selexys is proposing to conduct a PK pilot dose ranging study in cynomolgus monkey (Macaca fascicularis) to assess safety and PK of the anti-PSGL-1 antibody...
  8. Dorsal Column Stimulation as a New Therapy for Motor Disorders
    Miguel A L Nicolelis; Fiscal Year: 2013
    ..aim is to evaluate DCS in two nonhuman primate species, owl monkeys (Aotus trivirgatus) and rhesus macaques (Macaca mulatta), treated with 6-hydroxydopamine...
  9. Visual Processing and Smooth Eye Movements
    Michael J Mustari; Fiscal Year: 2012
    ..animal models for studying the development of the visual and oculomotor systems by raising infant monkeys (Macaca mulatta) with either surgical or prism induced strabismus...
  10. Large-Scale Discovery of Functional Genetic Variation in Rhesus Macaques
    JEFFREY A ROGERS; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Rhesus macaques (Macaca mulatta) are the most widely used nonhuman primate in biomedical research...
  11. The Immunogenetics of Macaques Used in Biodefense Research
    ALESSANDRO D SETTE; Fiscal Year: 2011
    Rhesus macaques (Macaca mulatta) and Cynomolgus macaques (Macaca fascicularis), are widely used as models of disease pathogenesis in humans and for evaluating vaccines and therapeutics against microbial pathogens, including emerging ..
  12. Primate Model of Mycoplasma genitalium
    Patricia A Totten; Fiscal Year: 2010
    ..housed at the University of Washington, the availability of the cervical infection model of pigtailed macaques (Macaca nemestrina) developed by Dr...
  13. Large-Scale Discovery of Functional Genetic Variation in Rhesus Macaques
    JEFFREY A ROGERS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Rhesus macaques (Macaca mulatta) are the most widely used nonhuman primate in biomedical research...
  14. Development of a Live Combinational Microbicide for Women
    Qiang Xu; Fiscal Year: 2010
    ..We will employ a Chinese rhesus macaque (Macaca mulatta) model that allows persistent vaginal colonization of L...
  15. Neurodegeneration in Aged SIV-Infected Primates
    Clayton A Wiley; Fiscal Year: 2013
    ..propose to use a well-established non-human primate (NHP) model of chronic lentiviral infection, SIV infection of Macaca mulatta (Rhesus Macaque RM), to model HAND in aged macaques (>20 years old), map the neurological signs to ..
  16. STUDIES OF ALPHA-DEFENSINS IN PRIMATE INNATE IMMUNITY
    Andre J Ouellette; Fiscal Year: 2010
    ..purpose of this research is to investigate the role of alpha-defensins in innate immunity of the rhesus macaque (Macaca mulatta)...
  17. Efficacy of a Novel Neuroprotective Compound in Nonhuman Primate
    Andrew A Pieper; Fiscal Year: 2013
    ..Rhesus macaques (Macaca mulatta) provide a useful proxy for efficacy in the human, as they demonstrate many features of human physiology, ..
  18. ESTABLISHMENT OF A SPF RHESUS MACAQUE COLONY
    LARRY BILL CUMMINS; Fiscal Year: 2011
    ..goals of this project are to increase the nation's capacity to produce pedigreed specific pathogen free (SPF) Macaca mulatta for AIDS-related research by maintaining a production colony of Indian-origin rhesus monkeys that are SPF ..
  19. ESTABLISHMENT OF A SPF RHESUS MACAQUE COLONY
    John L Vandeberg; Fiscal Year: 2013
    ..are to contribute to the nation's capacity to produce pedigreed, specific pathogen free (SPF) rhesus monkeys (Macaca mulatta) for AIDS-related research by maintaining a production colony of Indian-origin rhesus monkeys that are SPF ..
  20. DEVELOPMENT OF A PRIMATE GENOMIC RESOURCE
    Michael G Katze; Fiscal Year: 2012
    ..upon resources constructed during the original funding period in which we developed extensive rhesus macaque (Macaca mulatta)-specific genomic tools...
  21. Pre-Clinical Trial of MSC-Based Therapy for CNS Disease
    Donald G Phinney; Fiscal Year: 2010
    ..as mesenchymal stem cells (MSCs) will be injected unilaterally into the caudate putamen of infant rhesus macaques (Macaca mulatta) using stereotaxic coordinates determined by MRI...
  22. Myocardial passive stiffness: effect of aging.
    WILLIAM CORSON HUNTER; Fiscal Year: 2010
    ..By utilizing a primate model (Macaca fascicularis) - rather than a rodent model - the conclusions from this project will provide greater insight into ..
  23. ESTABLISHMENT OF SPF RHESUS MACAQUE BREEDING COLONY: HIV GENOME
    Keith G Mansfield; Fiscal Year: 2011
    ..The limited availability of Indian-origin rhesus macaques (Macaca mulatta) specific pathogen free of B virus (BV), Simian T lymphotropic Virus (STLV-1), Simian Retrovirus Type D (..
  24. The NEPRC SPF Rhesus Macaque Breeding Colony
    R Paul Johnson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Simian Immunodeficiency Virus (SlV)-infected Indian-origin rhesus monkey (Macaca mulatta) is the premiere animal model of human AIDS and has led to important advances in our understanding of ..
  25. SIMIAN VACCINE EVALUATION UNIT (SVEU)
    Dave Anderson; Fiscal Year: 2011
    ..Acquisition and testing of non-human primates (Primary emphasis will be on rhesus macaques (Macaca mulatta) of Indian origin, Chinese-origin macaques, or other nonhuman primate species, such as pig-tail macaques (..
  26. SIMIAN VACCINE EVALUATION UNIT (SVEU)
    Phillip D Markham; Fiscal Year: 2011
    ..are as follows: 1 Acquisition and testing of non-human primates (Primary emphasis will be on rhesus macaques (Macaca mulatta) of Indian origin, Chinese-origin macaques, or other nonhuman primate species, such as pig-tail macaques (..
  27. SIMIAN VACCINE EVALUATION UNIT (SVEU)
    Phillip D Markham; Fiscal Year: 2010
    ..are as follows: 1 Acquisition and testing of non-human primates (Primary emphasis will be on rhesus macaques (Macaca mulatta) of Indian origin, Chinese-origin macaques, or other nonhuman primate species, such as pig-tail macaques (..
  28. SIMIAN VACCINE EVALUATION UNITS
    Mark Lewis; Fiscal Year: 2011
    ..Acquisition and testing of non-human primates (Primary emphasis will be on rhesus macaques (Macaca mulatta) of Indian origin, Chinese-origin macaques, or other nonhuman primate species, such as pig-tail macaques (..
  29. SIMIAN VACCINE EVALUATION UNITS
    Mark Lewis; Fiscal Year: 2010
    ..Acquisition and testing of non-human primates (Primary emphasis will be on rhesus macaques (Macaca mulatta) of Indian origin, Chinese-origin macaques, or other nonhuman primate species, such as pig-tail macaques (..
  30. Development of an SPF Macaca nemestrina Breeding Colony
    Robert J Adams; Fiscal Year: 2013
    ..five years of funding to continue support for a Specific Pathogen Free (SPF) colony of pig-tailed macaques (Macaca nemestrina) at the Johns Hopkins University that was first funded on September 21, 2006...
  31. Studying the evolution of gene regulation at the protein level in primates
    GEORGE HERBERT PERRY; Fiscal Year: 2010
    ..species, (ii) use this platform for comparisons of human, chimpanzee (Pan troglodytes), and rhesus macaque (Macaca mulatta) liver, kidney, heart, lung and testis tissues, and (iii) examine ratios of intra- and inter-specific ..
  32. Developing a Translational Monkey Model of Maternal Care
    ERIN LORAINE KINNALLY; Fiscal Year: 2013
    ..Rhesus macaques (Macaca mulatta) are one of the best animal models of neurobehavioral development, as they are closely related to humans, ..
  33. Chronic Alcohol Abuse: Suppression of Bone Remodeling in Non-human Primates
    Urszula T Iwaniec; Fiscal Year: 2013
    ..objective, we have capitalized upon a unique opportunity to obtain bone specimens from rhesus macaque monkeys (Macaca mulatta) being studied in an ongoing NIAAA-sponsored alcohol research project conducted at the Oregon National ..
  34. SPF BREEDING COLONIES AT THE YERKES NPRC
    Mark E Wilson; Fiscal Year: 2013
    ..Simian immunodeficiency virus (SIV) infection of rhesus macaques (Macaca mulatta) is the most effective pre-clinical model of HIV infection...
  35. Primate iPS lines using Retrovirus and TAT Protein Transduction
    COLIN EDWARD BISHOP; Fiscal Year: 2010
    ..We therefore propose to: (1) generate induced pluripotent stem cell lines (iPS) from the non-human primate, Macaca fascicularis (cynomolgus macaque) (2) To determine if M...
  36. Testing of novel system to deliver VRC01 in mouse model
    Hans Peter Kiem; Fiscal Year: 2012
    ..Our second specific aim will test for compatibility of the vector, and culture system with cells from the primate Macaca nemestrina in preparation for a phase II application...
  37. WaNPRC MACACA NEMESTRINA SPF BREEDING COLONY
    David M Anderson; Fiscal Year: 2011
    ..DESCRIPTION (provided by applicant): Macaca nemestrina are an invaluable resource for AIDS-related studies in vaccine development, therapeutic agent discovery,..
  38. An Experimental Investigation into Staging CTS Utilizing Portable Ultrasound...
    Kevin D Evans; Fiscal Year: 2011
    ..considered a clinical standard and it is important to trend the ultrasound data against these measures in the 8 macaca fascicularis that are moving from baseline to recovery of MMN...
  39. Amblyopia and study of cortical mechanisms
    Yuzo M Chino; Fiscal Year: 2013
    ..methods, we will study the receptive-field center and surround structures of V2 and V3 neurons of macaque monkeys (Macaca mulatta) at key developmental ages, and we will ask how experiencing binocularly discordant images early in life ..
  40. SYNAPTIC MECHANISMS OF THE GLOBUS PALLIDUS
    RONALD HUFFMAN; Fiscal Year: 1980
    ..b>Macaca mulatta monkeys anesthetized with chloralose-urethane were used as the experimental animal...
  41. Evolution and Emergence of Simian Retroviruses in South Asia
    Maxine L Linial; Fiscal Year: 2012
    Multiple primate species, including 5 species of macaques (Macaca mulatta, M. nemestrina, M. fascicularis, M. assamensis, M...
  42. Digital probabilistic MRI atlas of primate brain with toolkits for surgery guidan
    Hao Huang; Fiscal Year: 2010
    ..Atlas of macaque (Macaca mulatta) will be made. Atlases have been playing central roles for neurobiological studies on primate brains...
  43. Development of an SPF Macaca nemestrina Breeding Colony
    Robert J Adams; Fiscal Year: 2011
    The use of pig-tailed macaques (Macaca nemestrina) in all areas of medical research has increased to the point that demand exceeds supply and increased research activity in bioterrorism will undoubtedly increase the demand for nonhuman ..
  44. ECoG Correlates of Visuomotor Transformation and Application to a Force-Based BCI
    Jordan J Williams; Fiscal Year: 2012
    ..the differences in representation of movement across cortical areas, we will train three male rhesus monkeys (Macaca mulatta) on a 2-D center-out joystick task in which position of the joystick (used as a proxy for hand position) ..
  45. CARIBBEAN PRIMATE RESEARCH CENTER
    Melween I Martínez; Fiscal Year: 2013
    ..integrated facilities: (1) Cayo Santiago, a unique free-ranging island colony of Indian-origin rhesus monkeys (Macaca mulatta);(2) the Sabana Seca Field Station, the CPRC's headquarters located 10 miles outside of San Juan, ..
  46. DEVELOPMENT OF A SPF PIGTAIL MACAQUE BREEDING COLONY
    ROBERT DRUILHET; Fiscal Year: 2000
    DESCRIPTION (Adapted from the applicant's abstract): Macaca nemestrina is much sought after as a nonhuman primate model of AIDS and AIDS- related research...
  47. Macaque Model of Carpal Tunnel Syndrome: Effects of Force and Posture Exposures
    Carolyn M Sommerich; Fiscal Year: 2010
    ..Research design and methods: Macaca fascicularis monkeys will be trained to perform a repetitive pinching task for daily food rations...
  48. Plasticity of the Visual Cortex
    Stelios Smirnakis; Fiscal Year: 2006
    ..of reorganization triggered by an acute retinal scotoma in the visual cortex of human and non-human primates (macaca mulatta)...
  49. Melatonin Receptors as Therapeutic Targets in Primates
    Margarita Dubocovich; Fiscal Year: 2006
    ..The experiments described here will be conducted in the diurnal non-human Primate, Macaca mulata which is a well established model for studies of sleep and circadian rhythms and is sensitive to the sleep ..
  50. Conference Support: NHP Models of Aging
    Joseph Kemnitz; Fiscal Year: 2001
    ..Microcebus murinus), marmosets (Callithrix jacchus), squirrel monkeys (Saimiri sciureus), cynomolgus monkeys (Macaca fascicularis), baboons (Papio hamadryas), and chimpanzees (Pan troglodytes)...
  51. WaNPRC MACACA NEMESTRINA SPF BREEDING COLONY
    DONALD RICK LEE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Macaca nemestrina are an invaluable resource for AIDS-related studies in vaccine development, therapeutic agent discovery, topical microbicide evaluation, and basic lentiviral virology, pathogenesis ..
  52. SPECIFIC PATHOGEN FREE MACAQUE BREEDING PROGRAM
    M Izard; Fiscal Year: 1999
    ..The recent discovery that pigtail macaques can be infected with HIV ensures that two macaque species (Macaca mulatta and nemestrina) will continue to be the most consistently and widely used animal model for AIDS and other ..
  53. Antiprogestins in Cynomolgus Endometriosis
    RONALD WIEHLE; Fiscal Year: 2003
    ..intention of Phase I of this SBIR program to determine effects on the eutopic endometrium of cynomolgus monkeys (Macaca fascicularis) following short-term administration, of our lead compound, CDB-4124...
  54. NON-INVASIVE ASSESSMENT OF PERIODONTAL DISEASE ACTIVITY
    CHRISTINE NIEKRASH; Fiscal Year: 1990
    ..The cynomolgus monkey (Macaca fascicularis) will be used because this animal will predictably develop actively-destructive periodontal lesions ..
  55. NEURON TRANSPLANT THERAPY: A MODEL OF PARKINSONISM
    MARK DUBACH; Fiscal Year: 1990
    ..We will apply a newly developed model that meets these requirements. Dopaminergic cells of Macaca fascicularis are destroyed by unilateral neurotoxin injections directly into the substantia nigra, resulting in a ..
  56. IMMUNE RESPONSES TO CLYCOSYLATION-MODIFIED SIV VACCINES
    David Montefiori; Fiscal Year: 1993
    ..Therefore, the objectives of this proposal are to elicit in rhesus macaques (Macaca mulatta) immune responses to glycosylation-modified, whole SIV vaccines, and to compare the effectiveness of these ..
  57. RELATION BETWEEN SPACE AND AGGRESSION IN RHESUS MACAQUES
    Frans De Waal; Fiscal Year: 1992
    Research institutions have recently come under attack for trauma in their rhesus monkeys (Macaca mulatta). The fighting is blamed on crowded housing conditions...
  58. DEVELOPMENT OF A VACCINE FOR HUMAN PERIODONTITIS
    ROY PAGE; Fiscal Year: 2001
    ..The Principal Investigator has shown that immunization of the nonhuman primate Macaca fascicularis, using a killed P...
  59. NEURAL MECHANISMS OF SIZE PERCEPTION
    John Allman; Fiscal Year: 2001
    ..representations in cortical areas for object vision, V1, V2, V4, and IT in awake, behaving macaque monkeys (Macaca mulatta)...
  60. NHP Reagent Resource for immune-mediated diseases, tranplantation, and infectious
    MATT BURDETSKY; Fiscal Year: 2011
    ..The NHP species covered by these contracts are the Cynomolgus macaque (Macaca fasicularis), Indian and Chinese Rhesus macaques (Macaca mulatta), and Pigtail macaque (Macaca nemestrina);MHC ..
  61. Nonhuman Primate Reagent Resource
    David Watkins; Fiscal Year: 2009
    ..The NHP species covered by these contracts are the Cynomolgus macaque (Macaca fasicularis), Indian and Chinese Rhesus macaques (Macaca mulatta), and Pigtail macaque (Macaca nemestrina);MHC ..
  62. SIV Encephalitis and Disease Progression
    Clayton Wiley; Fiscal Year: 2009
    ..We propose to use SIV infection of Macaca nemestrina and Macaco mullata as models of HIV encephalitis to test several hypotheses related to our theory of ..
  63. MATERNAL-FETAL TRANSMISSION OF SIV IN MACAQUES
    Hans Ochs; Fiscal Year: 1992
    ..Principal Investigator proposes to develop a model of maternal-fetal transmission of SIV in pigtailed macaques (Macaca nemestrina)...
  64. Macaque Model and Gene Expression Profiling of SARS
    Michael Katze; Fiscal Year: 2009
    ..affected in fatal SARS cases is the respiratory tract, and of existing animal models, the cynomolgus macaque (Macaca fascicularis) best replicates the pulmonary pathogenesis associated with human SARS...
  65. ANTI-INFLAMMATORY THERAPIES NEUROTOXICALLY INDUCED PD
    Ole Isacson; Fiscal Year: 2004
    ..The progressive decline of dopamine (DA) terminals seen in idiopathic PD can be closely modeled in Macaca fascicularis by low-dose exposure to the mitochondrial toxin, MPTP, over nine to fourteen months...
  66. PERIODONTAL MICROBIOTA ACQUISITION: MOTHER-INFANT STUDI
    JAYNE DELANEY; Fiscal Year: 1991
    ..24 months of the R23 project on the acquisition of periodontal microorganisms in the newborn and maturing primate Macaca fascicularis, and our initial studies on mother-infant transmission of specific microorganisms know to be involved ..
  67. CLONING & BIOLOGIC FUNCTION OF LEUKOTOXIN
    Jeffrey Ebersole; Fiscal Year: 1991
    ..e. Macaca fascicularis) but not other mammalian species...