cercopithecus aethiops

Summary

Summary: A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannas of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.

Top Publications

  1. pmc Roles for endocytosis and low pH in herpes simplex virus entry into HeLa and Chinese hamster ovary cells
    Anthony V Nicola
    Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:5324-32. 2003
  2. ncbi Identification and characterization of a cross-neutralization epitope of Enterovirus 71
    Chia Chyi Liu
    Vaccine R and D Center, National Health Research Institutes, Zhunan Town, Miaoli County 350, Taiwan
    Vaccine 29:4362-72. 2011
  3. ncbi Bats are natural reservoirs of SARS-like coronaviruses
    Wendong Li
    Institute of Zoology, Chinese Academy of Sciences CAS, Beijing, China
    Science 310:676-9. 2005
  4. pmc Mechanisms determining the morphology of the peripheral ER
    Yoko Shibata
    Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 143:774-88. 2010
  5. ncbi Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection
    Kartik Chandran
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 308:1643-5. 2005
  6. pmc Peroxisomes are signaling platforms for antiviral innate immunity
    Evelyn Dixit
    Division of Gastroenterology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Cell 141:668-81. 2010
  7. pmc Purification and characterization of enterovirus 71 viral particles produced from vero cells grown in a serum-free microcarrier bioreactor system
    Chia Chyi Liu
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
    PLoS ONE 6:e20005. 2011
  8. ncbi Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family
    R I Montgomery
    Northwestern University Medical School, Department of Microbiology Immunology, Chicago, Illinois 60611, USA
    Cell 87:427-36. 1996
  9. pmc Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein
    Kathryn Schornberg
    Department of Microbiology, University of Virginia, 1300 Jefferson Park Ave, Charlottesville, Virginia 22908 0734, USA
    J Virol 80:4174-8. 2006
  10. pmc Monoclonal antibodies that bind to domain III of dengue virus E glycoprotein are the most efficient blockers of virus adsorption to Vero cells
    W D Crill
    Arbovirus Disease Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80522, USA
    J Virol 75:7769-73. 2001

Detail Information

Publications248 found, 100 shown here

  1. pmc Roles for endocytosis and low pH in herpes simplex virus entry into HeLa and Chinese hamster ovary cells
    Anthony V Nicola
    Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:5324-32. 2003
    ..The results suggest that HSV can utilize two distinct entry pathways, depending on the type of cell encountered...
  2. ncbi Identification and characterization of a cross-neutralization epitope of Enterovirus 71
    Chia Chyi Liu
    Vaccine R and D Center, National Health Research Institutes, Zhunan Town, Miaoli County 350, Taiwan
    Vaccine 29:4362-72. 2011
    ..Thus, VP2-28 could be used as the surrogate biomarker in the potency testing of candidate EV71 vaccines...
  3. ncbi Bats are natural reservoirs of SARS-like coronaviruses
    Wendong Li
    Institute of Zoology, Chinese Academy of Sciences CAS, Beijing, China
    Science 310:676-9. 2005
    ..The human and civet isolates of SARS-CoV nestle phylogenetically within the spectrum of SL-CoVs, indicating that the virus responsible for the SARS outbreak was a member of this coronavirus group...
  4. pmc Mechanisms determining the morphology of the peripheral ER
    Yoko Shibata
    Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 143:774-88. 2010
    ..These proteins may generate sheets by stabilizing the high curvature of edges...
  5. ncbi Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection
    Kartik Chandran
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 308:1643-5. 2005
    ..CatB and CatB/CatL inhibitors diminish the multiplication of infectious EboV-Zaire in cultured cells and may merit investigation as anti-EboV drugs...
  6. pmc Peroxisomes are signaling platforms for antiviral innate immunity
    Evelyn Dixit
    Division of Gastroenterology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Cell 141:668-81. 2010
    ..The interferon regulatory factor IRF1 plays a crucial role in regulating MAVS-dependent signaling from peroxisomes. These results establish that peroxisomes are an important site of antiviral signal transduction...
  7. pmc Purification and characterization of enterovirus 71 viral particles produced from vero cells grown in a serum-free microcarrier bioreactor system
    Chia Chyi Liu
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
    PLoS ONE 6:e20005. 2011
    ..Enterovirus 71 (EV71) infections manifest most commonly as a childhood exanthema known as hand-foot-and-mouth disease (HFMD) and can cause neurological disease during acute infection...
  8. ncbi Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family
    R I Montgomery
    Northwestern University Medical School, Department of Microbiology Immunology, Chicago, Illinois 60611, USA
    Cell 87:427-36. 1996
    ..The contribution of HVEM to HSV entry into human cells was demonstrable in activated T cells. HVEM, the first identified mediator of HSV entry, is a new member of the TNF/NGF receptor family...
  9. pmc Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein
    Kathryn Schornberg
    Department of Microbiology, University of Virginia, 1300 Jefferson Park Ave, Charlottesville, Virginia 22908 0734, USA
    J Virol 80:4174-8. 2006
    ..These and other results support a model in which CatB and CatL prime GP by generating a 19-kDa intermediate that can be acted upon by an as yet unidentified endosomal/lysosomal enzyme to trigger fusion...
  10. pmc Monoclonal antibodies that bind to domain III of dengue virus E glycoprotein are the most efficient blockers of virus adsorption to Vero cells
    W D Crill
    Arbovirus Disease Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80522, USA
    J Virol 75:7769-73. 2001
    ..These results extend our understanding of the structure-function relationships in the E glycoprotein of DEN virus and provide the first direct evidence that domain III encodes the primary flavivirus receptor-binding motif...
  11. ncbi Selection and characterization of vaccine strain for Enterovirus 71 vaccine development
    Jui Yuan Chang
    Vaccine R and D Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Township, Miaoli County 350, Taiwan
    Vaccine 30:703-11. 2012
    ..Therefore, these results provide valuable information for cell-based EV71 vaccine development...
  12. pmc The endoplasmic reticulum provides the membrane platform for biogenesis of the flavivirus replication complex
    Leah K Gillespie
    Department of Microbiology, La Trobe University, Bundoora, Melbourne 3086, Australia
    J Virol 84:10438-47. 2010
    ..In addition, we provide data that indicate that a majority of the viral RNA species housed within the RC is in a double-stranded RNA (dsRNA) form...
  13. ncbi Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration
    Takashi Watanabe
    Department of Cell Pharmacology, Nagoya University, Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466 8550, Japan
    Dev Cell 7:871-83. 2004
    ....
  14. pmc Inhibition of interferon signaling by dengue virus
    Jorge L Munoz-Jordan
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029
    Proc Natl Acad Sci U S A 100:14333-8. 2003
    ..This protein, encoded by a positive strand RNA virus, is implicated as an IFN-signaling inhibitor...
  15. ncbi Image-guided radiovirotherapy for multiple myeloma using a recombinant measles virus expressing the thyroidal sodium iodide symporter
    David Dingli
    Molecular Medicine Program, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Blood 103:1641-6. 2004
    ..Testing in other radiosensitive cancers is warranted...
  16. pmc Multicolor super-resolution imaging with photo-switchable fluorescent probes
    Mark Bates
    School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
    Science 317:1749-53. 2007
    ..Using this approach, we demonstrate multicolor imaging of DNA model samples and mammalian cells with 20- to 30-nanometer resolution. This technique will facilitate direct visualization of molecular interactions at the nanometer scale...
  17. pmc MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay
    Georg Stoecklin
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 23:1313-24. 2004
    ..Our data reveal the mechanism by which the p38-MAPK/MK2 kinase cascade inhibits TTP-mediated degradation of ARE-containing transcripts and thereby contributes to lipopolysaccharide-induced TNFalpha expression...
  18. pmc Endoproteolytic processing of the lymphocytic choriomeningitis virus glycoprotein by the subtilase SKI-1/S1P
    Winfried R Beyer
    Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, D 20251 Hamburg, Germany
    J Virol 77:2866-72. 2003
    ..In agreement with the identified consensus motif, we show that the cellular subtilase SKI-1/S1P cleaves LCMV GP...
  19. pmc Small rho GTPases and cholesterol biosynthetic pathway intermediates in African swine fever virus infection
    Jose I Quetglas
    Departamento de Biotecnologia Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria, INIA, Madrid, Spain
    J Virol 86:1758-67. 2012
    ....
  20. pmc Localization and characterization of flavivirus envelope glycoprotein cross-reactive epitopes
    Wayne D Crill
    Arbovirus Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, P O Box 2087, Fort Collins, CO 80522, USA
    J Virol 78:13975-86. 2004
    ..The third epitope consists of discontinuous residues that are structurally related to the strictly conserved tryptophan at dengue virus serotype 2 E-glycoprotein position 231...
  21. ncbi Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
    V Stalin Raj
    Department of Viroscience, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Nature 495:251-4. 2013
    ..In addition, it will contribute critically to our understanding of the pathogenesis and epidemiology of this emerging human coronavirus, and may facilitate the development of intervention strategies...
  22. doi Subdiffraction-resolution fluorescence imaging with conventional fluorescent probes
    Mike Heilemann
    Angewandte Laserphysik and Laserspektroskopie, Universitat Bielefeld, Universitatsstrasse 25, 33615 Bielefeld, Germany
    Angew Chem Int Ed Engl 47:6172-6. 2008
  23. ncbi Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells
    Oleg O Glebov
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Cell Biol 8:46-54. 2006
    ..We propose that flotillin-1 is one determinant of a clathrin-independent endocytic pathway in mammalian cells...
  24. pmc Dengue virus ensures its fusion in late endosomes using compartment-specific lipids
    Elena Zaitseva
    Section on Membrane Biology, Laboratory of Cellular and Molecular Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 6:e1001131. 2010
    ....
  25. pmc Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner
    Asuka Nanbo
    Influenza Research Institute, Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Pathog 6:e1001121. 2010
    ..These findings provide new insights into the lifecycle of Ebolavirus and may aid in the development of therapeutics for Ebolavirus infection...
  26. pmc The small RING finger protein Z drives arenavirus budding: implications for antiviral strategies
    Mar Perez
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:12978-83. 2003
    ..Moreover, members of the vacuolar protein sorting pathway appear to play an important role in arena-virus budding. These findings open possibilities for antiviral strategies to combat LFV and other hemorrhagic fever arenaviruses...
  27. ncbi Regulation of androgen receptor activity by tyrosine phosphorylation
    Zhiyong Guo
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Cell 10:309-19. 2006
    ....
  28. pmc A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes
    Albert Lu
    Departament de Biologia Cellular, Immunologia i Neurociencies, Institut d Investigacions Biomediques August Pi i Sunyer, Serveis Cientificotecnics, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    J Cell Biol 184:863-79. 2009
    ..Altogether, this study reveals novel aspects about KRas intracellular trafficking and signaling, shedding new light on the mechanisms controlling Ras regulation in the cell...
  29. ncbi Eradication of solid human breast tumors in nude mice with an intravenously injected light-emitting oncolytic vaccinia virus
    Qian Zhang
    Genelux Corporation, San Diego Science Center, San Diego, California 92109, USA
    Cancer Res 67:10038-46. 2007
    ..These findings suggest that immune activation may combine with viral oncolysis to induce tumor eradication in this model, providing a novel perspective for the design of oncolytic viral therapies for human cancers...
  30. pmc Shiga toxin subtypes display dramatic differences in potency
    Cynthia A Fuller
    Molecular Genetics, Biochemistry, and Microbiology, Room 3109, 231 Albert Sabin Way, ML 524, University of Cincinnati, Cincinnati, OH 45267 0524, USA
    Infect Immun 79:1329-37. 2011
    ..In vivo potency in mice was also assessed. Stx2b and Stx2c had potencies similar to that of Stx1, while Stx2a, Stx2d, and elastase-cleaved Stx2d were 40 to 400 times more potent than Stx1...
  31. ncbi Neuroligin 2 is exclusively localized to inhibitory synapses
    Frederique Varoqueaux
    Max Planck Institute for Experimental Medicine, Department of Molecular Neurobiology, Gottingen, Germany
    Eur J Cell Biol 83:449-56. 2004
    ..Our findings identify neuroligin 2 as a new cell adhesion protein specific for inhibitory synapses and open new avenues for identifiying the constituents of this unique type of postsynaptic specialization...
  32. ncbi Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin
    Alexandros Poulopoulos
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Neuron 63:628-42. 2009
    ..Deletion of neuroligin 2 in mice perturbs GABAergic and glycinergic synaptic transmission and leads to a loss of postsynaptic specializations specifically at perisomatic inhibitory synapses...
  33. ncbi Conserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptor
    Jens H Kuhn
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA
    J Biol Chem 281:15951-8. 2006
    ..These studies identify the receptor-binding domains of both viruses, indicate that these viruses utilize a common receptor, and suggest that a single small molecule or vaccine can be developed to inhibit infection of all filoviruses...
  34. pmc Cellular entry of ebola virus involves uptake by a macropinocytosis-like mechanism and subsequent trafficking through early and late endosomes
    Mohammad F Saeed
    Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS Pathog 6:e1001110. 2010
    ..The findings greatly expand our understanding of the ZEBOV entry mechanism that can be applied to development of new therapeutics as well as provide potential insight into the trafficking and entry mechanism of other filoviruses...
  35. pmc TREK-1, a K+ channel involved in neuroprotection and general anesthesia
    C Heurteaux
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, Institut Paul Hamel, Sophia Antipolis, Valbonne, France
    EMBO J 23:2684-95. 2004
    ..Trek1-/- mice are also resistant to anesthesia by volatile anesthetics. TREK-1 emerges as a potential innovative target for developing new therapeutic agents for neurology and anesthesiology...
  36. ncbi Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expression
    Jeffrey Vieira
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98109 8070, USA
    Virology 325:225-40. 2004
    ..This work also demonstrated strong synergy between KSHV/RTA and butyrate for the activation of KSHV lytic replication and the production of infectious virus...
  37. ncbi Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170
    Masaki Fukata
    Department of Cell Pharmacology, Nagoya University, Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466 8550, Japan
    Cell 109:873-85. 2002
    ..These results indicate that Rac1/Cdc42 marks special cortical spots where the IQGAP1 and CLIP-170 complex is targeted, leading to a polarized microtubule array and cell polarization...
  38. pmc Cellular factors required for Lassa virus budding
    Shuzo Urata
    First Department of Forensic Science, National Research Institute of Police Science, Kashiwa 277 0882, Japan
    J Virol 80:4191-5. 2006
    ..Our data may provide a clue to develop an effective antiviral strategy for Lassa virus...
  39. ncbi Quantitation of flaviviruses by fluorescent focus assay
    Anne F Payne
    The Arbovirus Laboratories, Wadsworth Center, New York State Department of Health, 5668 State Farm Rd, Slingerlands, NY 12159, USA
    J Virol Methods 134:183-9. 2006
    ..In addition, these viruses can be quantitated by FFA on a mosquito cell line (C6/36), which does not support plaque formation. The FFA for flaviviruses was validated for accuracy, precision, specificity, and robustness of the assay...
  40. ncbi High immunogenic enterovirus 71 strain and its production using serum-free microcarrier Vero cell culture
    Chia Chyi Liu
    Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan
    Vaccine 25:19-24. 2007
    ..Therefore, serum-free microcarrier culture is a valuable process for developing inactivated EV71 vaccines...
  41. pmc Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix
    Jean Paul ten Klooster
    Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, Netherlands
    J Cell Biol 172:759-69. 2006
    ..These data provide a model for the intracellular targeting and localized activation of Rac1 through its exchange factor beta-Pix...
  42. pmc Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopment
    Helen L Zenner
    Division of Virology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
    J Virol 85:8012-21. 2011
    ....
  43. pmc The Ebola virus ribonucleoprotein complex: a novel VP30-L interaction identified
    A Groseth
    National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg R3E 3R2, Canada
    Virus Res 140:8-14. 2009
    ..The identification of these interactions allows a preliminary model of the EBOV RNP complex structure to be proposed, and may provide insight into filovirus transcriptional regulation...
  44. pmc Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry
    Ayato Takada
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Virol 78:2943-7. 2004
    ..We propose that filoviruses use different C-type lectins to gain cellular entry, depending on the cell type, and promote efficient viral replication...
  45. pmc Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses
    Friedemann Weber
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    J Virol 80:5059-64. 2006
    ..Surprisingly, however, no dsRNA signals were detected for negative-strand RNA viruses. Thus, dsRNA is indeed a general feature of most virus groups, but negative-strand RNA viruses appear to be an exception to that rule...
  46. pmc Characterization of Ebola virus entry by using pseudotyped viruses: identification of receptor-deficient cell lines
    R J Wool-Lewis
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6076, USA
    J Virol 72:3155-60. 1998
    ....
  47. pmc Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate
    Roberto Zoncu
    Department of Cell Biology and Howard Hughes Medical Institute, Kavli Institute For Neuroscience and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 104:3793-8. 2007
    ..These findings demonstrate the critical importance of PI(4,5)P(2) in clathrin coat dynamics and Arp2/3-dependent actin regulation...
  48. pmc Dengue virus type 1 nonstructural glycoprotein NS1 is secreted from mammalian cells as a soluble hexamer in a glycosylation-dependent fashion
    M Flamand
    Unité des Arbovirus et Virus des Fièvres Hémorragiques, Institut Pasteur, 75724 Paris Cedex 15, 91198 Gif sur Yvette Cedex, France
    J Virol 73:6104-10. 1999
    ..These results, together with observations related to the absence of secretion of NS1 from Den-infected insect cells, suggest that maturation and secretion of hexameric NS1 depend on the glycosylation status of the host cell...
  49. pmc Epigallocatechin gallate inactivates clinical isolates of herpes simplex virus
    Charles E Isaacs
    Department of Developmental Biochemistry, Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Antimicrob Agents Chemother 52:962-70. 2008
    ..EGCG is stable in the pH range found in the vagina and appears to be a promising candidate for use in a microbicide to reduce HSV transmission...
  50. pmc Incorporation of the green fluorescent protein into the herpes simplex virus type 1 capsid
    P Desai
    Virology Laboratories, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 72:7563-8. 1998
    ....
  51. ncbi Flavivirus induces interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-kappaB activation
    Tsung Hsien Chang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
    Microbes Infect 8:157-71. 2006
    ..Therefore, we suggest that JEV and DEN-2 initiate the host innate immune response through a molecular mechanism involving RIG-I/IRF-3 and PI3K/NF-kappaB signaling pathways...
  52. ncbi Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1
    Jun Arii
    Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Nature 467:859-62. 2010
    ..The identification of NMHC-IIA as an HSV-1 entry receptor and the involvement of NM-IIA regulation in HSV-1 infection provide an insight into HSV-1 entry and identify new targets for antiviral drug development...
  53. ncbi Imaging of lipid biosynthesis: how a neutral lipid enters lipid droplets
    Lars Kuerschner
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, D 01307 Dresden, Germany
    Traffic 9:338-52. 2008
    ..In vitro assays on purified lipid droplets show that this fraction of the biosynthetic TG is directly inserted into the growing droplet...
  54. pmc Tyro3 family-mediated cell entry of Ebola and Marburg viruses
    Masayuki Shimojima
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Virol 80:10109-16. 2006
    ..Antibody to Axl inhibited infection of pseudotype viruses in a number of Axl-positive cell lines. These results implicate each Tyro3 family member as a cell entry factor in filovirus infection...
  55. ncbi Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression
    Rochelle M Hines
    Department of Psychiatry, Brain Research Centre, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurosci 28:6055-67. 2008
    ..These findings may provide the neural basis for E/I imbalance and altered behavior associated with neurodevelopmental disorders...
  56. ncbi Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing
    Chi Zhang
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 278:35325-36. 2003
    ....
  57. ncbi High CD46 receptor density determines preferential killing of tumor cells by oncolytic measles virus
    Bambi D Anderson
    Molecular Medicine Program, Mayo Clinic Cancer Center, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Res 64:4919-26. 2004
    ..Discrimination between high and low CD46 receptor density provides a compelling basis for the oncolytic specificity of MV-Edm and establishes MV-Edm as a promising CD46-targeted cancer therapeutic agent...
  58. ncbi Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes
    M G Ford
    Medical Research Council MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Science 291:1051-5. 2001
    ..This was shown by using purified components and a budding assay on preformed lipid monolayers. In the presence of AP180, clathrin lattices formed on the monolayer. When AP2 was also present, coated pits were formed...
  59. ncbi A class of membrane proteins shaping the tubular endoplasmic reticulum
    Gia K Voeltz
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Cell 124:573-86. 2006
    ..The simultaneous absence of the reticulons and Yop1p in S. cerevisiae results in disrupted tubular ER. We propose that these "morphogenic" proteins partition into and stabilize highly curved ER membrane tubules...
  60. ncbi Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer
    Motohide Uemura
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Shirokanedai 4 6 1 Minato ku, Tokyo 108 8639, Japan
    Cancer Sci 99:81-6. 2008
    ....
  61. ncbi A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development
    Atsushi Kamiya
    Department of Psychiatry Neurobiology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, CMSC 8 117, Baltimore, MD 21287, USA
    Nat Cell Biol 7:1167-78. 2005
    ..These results indicate that DISC1 is involved in cerebral cortex development, and suggest that loss of DISC1 function may underlie neurodevelopmental dysfunction in schizophrenia...
  62. ncbi Contribution of the respiratory syncytial virus G glycoprotein and its secreted and membrane-bound forms to virus replication in vitro and in vivo
    M N Teng
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, 7 Center Dr. MSC 0720, Bethesda, Maryland 20892-0720, USA
    Virology 289:283-96. 2001
    ..Thus, the putative heparin-binding domain is not the sole determinant of heparin sensitivity and is not a critical functional domain...
  63. pmc The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P
    O Lenz
    Institute of Virology, Philipps University, Robert Koch Strasse 17, 35037 Marburg, Germany
    Proc Natl Acad Sci U S A 98:12701-5. 2001
    ..To our knowledge, there have been no previous reports of this type of viral glycoprotein processing, one that may be an interesting target for antiviral therapy...
  64. pmc Heterocellular induction of interferon by negative-sense RNA viruses
    S Chen
    School of Biology, Centre for Biomolecular Sciences, BMS Building, North Haugh, University of St Andrews, St Andrews, Fife, KY16 9ST, UK
    Virology 407:247-55. 2010
    ..We show that only a limited number of infected cells are responsible for the production of IFN, and that this heterocellular production is a feature of the infecting virus as opposed to an intrinsic property of the cells...
  65. ncbi Generation of murine monoclonal antibodies which cross-neutralize human enterovirus genogroup B isolates
    Hsuen Wen Chang
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan Township, Miaoli County 350, Taiwan
    J Virol Methods 173:189-95. 2011
    ..It was also observed the monoclonal antibodies acted cooperatively in neutralizing the EV71/E59 virus...
  66. pmc Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network
    Seong H Park
    Cellular Neurology Unit, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke NINDS, NIH, Bethesda, Maryland 20892 3738, USA
    J Clin Invest 120:1097-110. 2010
    ..Thus, defects in tubular ER shaping and network interactions with the microtubule cytoskeleton seem to be the predominant pathogenic mechanism of HSP...
  67. pmc Assembly and maturation of the flavivirus Kunjin virus appear to occur in the rough endoplasmic reticulum and along the secretory pathway, respectively
    J M MacKenzie
    Clinical Medical Virology Centre, University of Queensland, St Lucia, Queensland 4072, Australia
    J Virol 75:10787-99. 2001
    ..The results suggest that the assembly of virions occurs within the lumen of the RER and that subsequent maturation occurs via the secretory pathway...
  68. ncbi Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology
    Sabine Kupzig
    Department of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
    Traffic 4:694-709. 2003
    ..Data from several experiments are consistent with this localization. We present a model in which BST-2/HM1.24 serves to link adjacent lipid rafts within the plasma membrane...
  69. pmc Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus
    Boyd Yount
    Department of Epidemiology and Microbiology, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Proc Natl Acad Sci U S A 100:12995-3000. 2003
    ....
  70. pmc Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis
    Han Jou Chen
    Division of Experimental Medicine, Faculty of Medicine, Centre for Neuroscience, Hammersmith Hospital, Imperial College London, London W12 0NN, United Kingdom
    J Biol Chem 285:40266-81. 2010
    ..In summary, we show that this newly identified mutation in human FALS has a pathogenic effect, supporting and reinforcing the role of VAPB as a causative gene of ALS...
  71. pmc Vesicular stomatitis virus-based Ebola vaccines with improved cross-protective efficacy
    Andrea Marzi
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, Montana 59840, USA
    J Infect Dis 204:S1066-74. 2011
    ..Our data demonstrate that cross-protection between the EBOV species can be achieved, although EBOV-GP alone cannot induce the required immune response...
  72. ncbi The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence
    J V Frangioni
    Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts 02215
    Cell 68:545-60. 1992
    ..The C-terminal 35 amino acids of PTP-1B are both necessary and sufficient for targeting to the ER. The finding of a tyrosine phosphatase on the ER suggests new possibilities for cellular events controlled by tyrosine phosphorylation...
  73. ncbi Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules
    Takashi Watanabe
    Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan
    J Cell Sci 122:2969-79. 2009
    ..Thus, phosphorylation of CLASP2 by GSK-3beta appears to control the regional linkage of microtubules to actin filaments through IQGAP1 for cell migration...
  74. pmc Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variants
    Matthew W McNatt
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York, United States of America
    PLoS Pathog 5:e1000300. 2009
    ....
  75. ncbi Continuous cell lines as a production system for influenza vaccines
    Yvonne Genzel
    Max Planck Institute for Dynamics of Complex Technical Systems, Bioprocess Engineering Magdeburg, Sandtorstr 1, Magdeburg 39106, Germany
    Expert Rev Vaccines 8:1681-92. 2009
    ..These encouraging developments for cell culture-based influenza virus production are summarized and an overview on potential cell substrates is given...
  76. pmc Cellular and viral requirements for rapid endocytic entry of herpes simplex virus
    Anthony V Nicola
    Medical Virology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1888, USA
    J Virol 78:7508-17. 2004
    ..Thus, similar to entry via direct penetration at the cell surface, HSV entry into cells by wortmannin-sensitive endocytosis is efficient, involves rapid cellular uptake of viral particles, and requires gB, gD, and gH-gL...
  77. pmc Amino acid residues in the fusion peptide pocket regulate the pH of activation of the H5N1 influenza virus hemagglutinin protein
    Mark L Reed
    Department of Infectious Diseases, MS 330, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    J Virol 83:3568-80. 2009
    ..Overall, the data show that residues comprising the fusion peptide pocket are important in triggering pH-dependent activation of the H5 HA protein...
  78. pmc The NS5 protein of the virulent West Nile virus NY99 strain is a potent antagonist of type I interferon-mediated JAK-STAT signaling
    Maudry Laurent-Rolle
    Laboratory of Virology, Rocky Mountain Laboratories, 903 S Fourth St, Hamilton, MT 59840, USA
    J Virol 84:3503-15. 2010
    ..Thus, a naturally occurring mutation is associated with the function of NS5 in IFN antagonism and may influence virulence of WNV field isolates...
  79. ncbi Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase
    Yi I Wu
    Department of Cell and Molecular Biology and Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    J Biol Chem 279:8278-89. 2004
    ..These data provide evidence for an additional mechanism for post-translational control of MT1-MMP activity and suggest that glycosylation of MT1-MMP may regulate its substrate targeting...
  80. ncbi Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy
    Anne Sophie Nicot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Department of Molecular Pathology, F 67400 Illkirch, France
    Nat Genet 39:1134-9. 2007
    ....
  81. pmc Peripheral ER structure and function
    Amber R English
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Curr Opin Cell Biol 21:596-602. 2009
    ....
  82. ncbi RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway
    Hiroaki Kajiho
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    J Cell Sci 116:4159-68. 2003
    ..These results indicate that RIN3 biochemically characterized as the stimulator and stabilizer for GTP-Rab5 plays an important role in the transport pathway from plasma membrane to early endosomes...
  83. pmc The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) functions as a dominant regulator of apoptosis in hippocampal neurons involving activation of the ERK survival pathway and upregulation of the antiapoptotic protein Bag-1
    D Perkins
    Departments of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore 21201, USA
    J Virol 77:1292-305. 2003
    ..Collectively, the data indicate that ICP10 PK-induced activation of the ERK survival pathway results in Bag-1 upregulation and overrides the proapoptotic JNK/c-Jun signal induced by other viral proteins...
  84. pmc Respiratory syncytial virus nonstructural proteins decrease levels of multiple members of the cellular interferon pathways
    Samer Swedan
    Department of Biochemistry and Molecular Biology, University of South Alabama, College of Medicine, 307 University Blvd, Mobile, AL 36688 0002, USA
    J Virol 83:9682-93. 2009
    ..Coimmunoprecipitation studies revealed that NS1 and NS2 form a heterodimer. Clearly, the NS proteins of RSV, working individually and together, regulate key signaling molecules of both the IFN activation and response pathways...
  85. ncbi Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5
    Yasuhiko Nakamura
    Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 366:174-9. 2008
    ..These results suggest that the SIRT3, SIRT4, and SIRT5 proteins exert distinct functions in mitochondria. In addition, the SIRT3 protein might function in nucleus...
  86. pmc Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases
    M B Calalb
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    Mol Cell Biol 15:954-63. 1995
    ..Our results indicate that phosphorylation of FAK by Src (or other Src family kinases) is an important step in the formation of an active signaling complex...
  87. ncbi Clathrin-mediated endocytosis of a lipid-raft-associated protein is mediated through a dual tyrosine motif
    Ruth Rollason
    Department of Biochemistry, University of Bristol, Bristol, BS8 1T, UK
    J Cell Sci 120:3850-8. 2007
    ....
  88. pmc Assembly and budding of Ebolavirus
    Takeshi Noda
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    PLoS Pathog 2:e99. 2006
    ..These data form a foundation for the identification and development of potential antiviral agents to combat the devastating disease caused by this virus...
  89. pmc Glycoprotein D receptor-dependent, low-pH-independent endocytic entry of herpes simplex virus type 1
    Richard S B Milne
    Department of Microbiology, University of Pennsylvania, School of Dental Medicine, 215 Levy Building, 240 South 40th Street, Philadelphia, PA 19104 6002, USA
    J Virol 79:6655-63. 2005
    ..Resistance to similar reagents should therefore not be taken as proof of HSV entry by a nonendosomal pathway. These data define a novel gD receptor-dependent acid-independent endocytic entry pathway for HSV...
  90. ncbi Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells
    Shumei Ren
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita 15 Nishi 7, Kita ku, Sapporo 060 0815, Japan
    J Biol Chem 281:32344-52. 2006
    ..The present work raises the possibility that inhibition of CagA multimerization abolishes pathophysiological activities of CagA that promote gastric carcinogenesis...
  91. pmc Severe acute respiratory syndrome coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strain
    Marc G Wathelet
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0576, USA
    J Virol 81:11620-33. 2007
    ..However, mutant virus replication was strongly attenuated in cells with an intact IFN response. Thus, nsp1 is likely a virulence factor that contributes to pathogenicity by favoring SARS-CoV replication...
  92. pmc Temporal analysis of Coxiella burnetii morphological differentiation
    Sherry A Coleman
    Coxiella Pathogenesis Unit, NIAID NIH, Rocky Mountain Laboratories, 903 S 4th Street, Hamilton, MT 59840, USA
    J Bacteriol 186:7344-52. 2004
    ..The experimental model described in this report will allow a global transcriptome and proteome analysis of C. burnetii developmental forms...
  93. ncbi DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
    M R Rountree
    The Johns Hopkins Oncology Center, Tumor Biology Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Genet 25:269-77. 2000
    ..Thus, DNMT1 not only maintains DNA methylation, but also may directly target, in a heritable manner, transcriptionally repressive chromatin to the genome during DNA replication...
  94. pmc Phenotype of a herpes simplex virus type 1 mutant that fails to express immediate-early regulatory protein ICP0
    Roger D Everett
    MRC Virology Unit, Institute of Virology, Glasgow G11 5JR, Scotland, United Kingdom
    J Virol 78:1763-74. 2004
    ....
  95. ncbi Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain
    Sinisa Urban
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Mol Cell 11:1425-34. 2003
    ..These results provide an explanation of how rhomboid proteases achieve specificity, and allow some rhomboid substrates to be predicted from sequence information...
  96. pmc Microtubule-mediated transport of incoming herpes simplex virus 1 capsids to the nucleus
    B Sodeik
    Yale University School of Medicine, Department of Cell Biology, New Haven, Connecticut 06520 8002, USA
    J Cell Biol 136:1007-21. 1997
    ..We propose that the incoming capsids bind to microtubules and use dynein to propel them from the cell periphery to the nucleus...
  97. pmc Differential inhibition of type I interferon induction by arenavirus nucleoproteins
    Luis Martinez-Sobrido
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Virol 81:12696-703. 2007
    ..Consistent with this observation, TCRV-infected cells also failed to inhibit interferon production...
  98. pmc N terminus is key to the dominant negative suppression of Ca(V)2 calcium channels: implications for episodic ataxia type 2
    Karen M Page
    Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 285:835-44. 2010
    ..Taken together, our evidence indicates that both the extreme N terminus and the Arg(52), Arg(54) motif are involved in the processes underlying dominant negative suppression...
  99. ncbi AIDS progression is associated with the emergence of IL-17-producing cells early after simian immunodeficiency virus infection
    Laure Campillo-Gimenez
    Institut National de la Santé et de la Recherche Médicale U 955, Faculté de Médecine de Créteil, Hopital Henri Mondor, Creteil, France
    J Immunol 184:984-92. 2010
    ..Altogether, these results demonstrate that IL-17-producing NKT are associated with the pathogenesis of SIV in RMs and suggest that TGF-beta and IL-18 play a role in their development...
  100. ncbi Real-time computation of subdiffraction-resolution fluorescence images
    S Wolter
    Applied Laser Physics and Laser Spectroscopy, Department of Physics, Bielefeld University, Universitatsstrasse 25, D 33615 Bielefeld, Germany
    J Microsc 237:12-22. 2010
    ....
  101. pmc During lytic infections, herpes simplex virus type 1 DNA is in complexes with the properties of unstable nucleosomes
    Jonathan J Lacasse
    Signal Transduction Research Group, Molecular Mechanisms of Growth Control Research Group, University of Alberta, 327C Heritage Medical Research Center, Edmonton, Alberta T6G 2S2, Canada
    J Virol 84:1920-33. 2010
    ..The HSV-1 DNAs in complexes fractionating as mono- to dinucleosomes were stabilized by cross-linking. Therefore, most HSV-1 DNA forms particularly unstable nucleosome-like complexes at 5 h of lytic infection...

Research Grants52

  1. Self-limiting, and Dominant-negative Herpes Simplex Virus Recombinants
    Feng Yao; Fiscal Year: 2007
    ..Specific Aim 4 will focus on investigating the influence of de novo expression of B7-1 and B7-2 by HSV-1 replication-defective vaccine virus on the augmentation of host immunity against HSV infection. [unreadable] [unreadable]..
  2. Brain and Behavioral Alterations After Methamphetamine
    William Melega; Fiscal Year: 2004
    ..METH dose protocol that reflects human METH abuse patterns will be administered to vervet monkeys (Cercopithecus aethiops sabaeus) housed in naturally composed social groups...
  3. NEUROAMINE RECEPTOR REG DURING INDUCTION & WITHDRAWAL
    Deborah Mash; Fiscal Year: 1993
    ..We propose to conduct these studies in animals taken from an experimental colony of Vervet monkeys (Cercopithecus aethiops) that have been previously characterized for their descriptive behaviors and alcohol preference...
  4. QTL Mapping of Impulsivity-related Traits Before and After a Stressful Life Chang
    Lynn Fairbanks; Fiscal Year: 2009
    ..This is a novel way of assessing the role of the gene-environment interactions in measuring effects of genetic variation on behavior traits ..
  5. Behavioral Genetics of Impulsivity
    Lynn Fairbanks; Fiscal Year: 2005
    ..Subjects for this research are 725 vervet monkeys (Cercopithecus aethiops sabaeus), living in naturally composed social groups in a multigenerational, pedigreed colony that ..
  6. Selective Prenatal Dopamine Damage in Non Human Primates
    John Elsworth; Fiscal Year: 2003
    ..Thus, the proposed work may lead ultimately to an animal model for one or more pediatric brain disorders. ..
  7. Estrogenic Effect on Hippocampal Theta Rhythm and Memory
    Csaba Leranth; Fiscal Year: 2004
    ....
  8. Negative Effects of Bisphenol A on the Monkey CNS
    Csaba Leranth; Fiscal Year: 2008
    ..Therefore, we propose to reveal the effect of BPA on estrogen-induced spine synapse formation in the brain of non-human primates, which will provide more relevance to human health. [unreadable] [unreadable] [unreadable]..
  9. Subcortical Estrogen Effect on The Hippocampus
    Csaba Leranth; Fiscal Year: 2005
    ..cholinergic and GABAergic septo-hippocampal neurons involved in mediating estrogenic effect to the hippocampus? and (d) Do SUM neurons mediate estrogenic effect to the hippocampus directly or indirectly, via the MSDB? ..
  10. Early experience and low 5-HT markers in alcohol abuse
    Mark Laudenslager; Fiscal Year: 2009
    ..Finally, involvement of the HPA axis in these relationships will be investigated as an exploratory goal. ..
  11. BEHAVIORAL AND PHYSIOLOGICAL CONSEQUENCES OF LOSS
    Mark Laudenslager; Fiscal Year: 2003
    ..The present application seeks to identify developmental factors affecting the HPA axis and the balance of CORT and DHEA with consequences for individual differences in rates of progression in immunodeficiency disease. ..
  12. Animal models to design & evaluate improved VZV vaccines
    WAYNE GRAY; Fiscal Year: 2007
    ..The study may also provide support for use of the VZV vaccine as a recombinant vector for immunization against other infectious agents, particularly human immunodeficiency virus (HIV). ..
  13. Mosquito Immunity to Alphaviruses
    Brian Foy; Fiscal Year: 2006
    ..3) Characterize the mechanisms that Culex tritaeniorhynchus mosquitoes use to clear Sindbis virus-infected midgut cells. [unreadable] [unreadable]..
  14. Bioreactor for Engineered Bioartificial Tissues (BATS)
    Albert Banes; Fiscal Year: 2005
    ..Expansion to a larger bioreactor chamber will allow biomedical researchers to develop better strategies for growth and testing of scaled up tissues for use in vivo in numerous connective tissue applications. ..
  15. MOLECULAR MECHANISM OF RENAL NA+ DEPENDENT COTRANSPORT
    Ana M Pajor; Fiscal Year: 2010
    ..Understanding how NaDC1 and SdcS work will help us to develop treatments for NaDC1-mediated diseases. ..
  16. CEREBROVASCULAR ION CHANNELS IN HYPERTENSION
    J Marc Simard; Fiscal Year: 2007
    ..abstract_text> ..
  17. Improving neural graft function in parkinsonian monkeys.
    DONALD REDMOND; Fiscal Year: 2007
    ..abstract_text> ..
  18. Genotypic and Phenotypic Analysis of West Nile virus, Yucatan Peninsula of Mexico
    Bradley Blitvich; Fiscal Year: 2008
    ..This information will help determine why there has not been an epidemic of WNV in the YP, and will identify risk factors associated with WNV disease. [unreadable] [unreadable] [unreadable]..
  19. GDNF Delivery to MPTP Monkeys by EIAV lentivirus and AAV
    DONALD REDMOND; Fiscal Year: 2008
    ..These studies aim to provide the necessary data to initiate successful clinical trials in Parkinson's patients at the earliest possible time. ..
  20. Pitx2 Function in Developing Mouse Brain Neurons
    Donna M Martin; Fiscal Year: 2010
    ..These results will help guide future experiments aimed at directing neural stem cell differentiation toward specific neuronal cell subtypes. ..
  21. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    ..Studies are proposed in this application to study the role of virus-like sequences in the onset and progression of environmentally-induced atherosclerosis in experimental systems. ..
  22. BETA 1 AND BETA 3 ADRENORECEPTORS
    JAMES GRANNEMAN; Fiscal Year: 2001
    ..Aim 2. To further characterize the differential signaling properties of beta1- beta3-AR and to examine the cellular and molecular basis. Specific Aim 3. To examine the molecular pharmacology of beta3-AR-selective agonists. ..
  23. PATHOPHYSIOLOGY OF NICOTINE IN CEREBRAL BLOOD VESSELS
    J Simard; Fiscal Year: 2004
    ....
  24. MOLECULAR MECHANISMS OF CHEMICAL ATHEROGENESIS
    Kenneth Ramos; Fiscal Year: 2005
    ..These studies will enable us to define the role of ARE/EpRE binding proteins in oxidant-induced atherogenesis and identify critical transacting factors involved in the atherogenic response to environmental injury. ..
  25. 2004 Mechanisms of Toxicity Gordon Research Conference
    Kenneth Ramos; Fiscal Year: 2004
    ..Thus, the 2004 conference is poised to continue its growth as the single leading small conference in toxicology. ..
  26. PHARYNGEAL MYOGENESIS AND ORGANOGENESIS IN C ELEGANS
    PETER OKKEMA; Fiscal Year: 2004
    ..Finally we are specifically examining role the PEB-l plays during pharyngeal development by isolating and characterizing apeb-1 mutant. ..
  27. FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENES
    Yun Fai Chris Lau; Fiscal Year: 2004
    ..Understanding the mechanisms of sex determination in mouse may shed insights on those in humans, and eventually may lead to developments of clinical diagnosis and treatment of gonadal dysgenesis and infertility. ..
  28. Mechanisms of Centrosome Reproduction in Animal Cells
    EDWARD HINCHCLIFFE; Fiscal Year: 2009
    ..abstract_text> ..
  29. UL34 and herpes simplex virus envelopment
    Richard J Roller; Fiscal Year: 2010
    ..3. We will fully characterize changes in the host cell nuclear lamina associated with infection and determine the mechanism by which UL34 and other viral proteins accomplish those changes. ..
  30. Pathogenesis of SIV in African green monkeys
    Ivona Pandrea; Fiscal Year: 2010
    ..Combined, these aims are designed to determine the viral and/or host factors responsible for resistance to AIDS. ..
  31. OSTEOPONTIN AND OXIDATIVE STRESS IN ATHEROGENESIS
    Kenneth Ramos; Fiscal Year: 2003
    ..These studies are important in view of the increasing scrutiny of the role of oxidative injury in the onset and progression of atherogenesis. ..
  32. Function and regulation of T-box factors in C. elegans
    Peter G Okkema; Fiscal Year: 2010
    ..elegans, and the results obtained will have a direct bearing on our understanding of these factors in all organisms. ..
  33. Peroxiredoxin 6 and Cataractogenesis
    Dhirendra P Singh; Fiscal Year: 2010
    ..The proposed studies will provide a sound scientific basis for developing an antioxidant-based therapy or combination of therapies for preventing cataractogenesis and age-associated degenerative diseases in general. ..
  34. Transformation of Cells by the REL Oncogene
    Thomas Gilmore; Fiscal Year: 2009
    ....
  35. Role of Leucine Metabolism in Leucine Signaling
    CHRISTOPHER JOHN LYNCH; Fiscal Year: 2010
    ..The implication of our ongoing research is that blocking the first step in BCAA metabolism with a drug, or to a less extent increasing dietary BCAAs, will promote weight loss. ..
  36. A High-Throughput Screen to Identify Small Molecule Compounds That Augment
    Brent Passer; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  37. HUMAN NEURAL STEM CELLS IN PRIMATE PARKINSON'S MODEL
    DONALD REDMOND; Fiscal Year: 2004
    ..The results will also advance understanding of useful methods for studying and treating a broad range of neurodegenerative, genetic, and traumatic conditions of the nervous system. ..
  38. Genetic analysis of congenital diaphragmatic hernia
    Anne Slavotinek; Fiscal Year: 2006
    ..abstract_text> ..
  39. Analysis of Therapeutic Adipose Tissue Remodeling
    JAMES GRANNEMAN; Fiscal Year: 2004
    ..2) To examine adipose tissue cellular dynamics during therapeutic remodeling induced by agonist activation of beta3-adrenergic receptors and PPAR-gamma. ..
  40. Arbovirus quasispecies-impact of arthropod transmission
    GREGORY EBEL; Fiscal Year: 2004
    ..abstract_text> ..
  41. Role of Pitx2 in the Mammalian Central Nervous System
    Donna Martin; Fiscal Year: 2005
    ..5-14.5) mouse diencephalon, 2) Develop and analyze mice with Pitx2 loss of function, and 3) Develop and analyze transgenic mice with CNS-specific Pitx2 gain of function. ..
  42. Reactive astrocytes from gliotic capsule
    J Marc Simard; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  43. TENDON CELLS:INTERACTIONS & RESPONSES TO STRESS IN VITRO
    Albert Banes; Fiscal Year: 2004
    ..Knowledge of how motion acts at the mechanistic level may lead to drug strategies for upregulating cell division and matrix expression with or without motion in aged or disabled patients. ..
  44. REGULATION OF ADIPOCYTE PROTEIN SYNTHESIS BY AMINO ACIDS
    Christopher Lynch; Fiscal Year: 2007
    ..The proposed studies will elucidate how leucine regulates mTOR and the roles of leucine stimulation of mTOR in adipose tissue physiology and obesity. ..
  45. Membrane Organization in Cell Signaling and Adhesion
    Tione Buranda; Fiscal Year: 2008
    ..Completion of the proposed work will yield a better mechanistic grasp of the dynamics of membrane organization as a factor in signaling and cell adhesion. ..
  46. Development of an VEE Replicon Vaccine Against Smallpox
    Kurt Kamrud; Fiscal Year: 2005
    ....
  47. Viral Genes Essential for MHV-68 Persistent Infection in the Spleen
    Ren Sun; Fiscal Year: 2008
    ..These viruses will strongly stimulate immune responses but will not establish persistent infection to cause diseases, thus a potential vaccine strategy. [unreadable] [unreadable] [unreadable]..
  48. CTL-BASED VACCINES FOR THE AIDS VIRUS
    David Watkins; Fiscal Year: 2003
    ..John Altman will synthesize MHC class I tetramers for CTL quantitation and Deborah Fuller will immunize animals using the gene gun. ..
  49. MECHANISM OF INTERFERON ACTION
    CHARLES SAMUEL; Fiscal Year: 2009
    ..Furthermore, elucidation of the actions of IFN at the molecular level is of importance in view of potential applications of interferon in the clinic. ..
  50. CENTER FOR CANCER SIGNALING NETWORKS
    Walter Atwood; Fiscal Year: 2009
    ..This award will fund the retention of a young assistant professor, enable the hiring of a research assistant and provide a reasonable budget for supplies. ..
  51. IgA-Antigen Uptake by Peyer's Patch M cells
    NICHOLAS MANTIS; Fiscal Year: 2003
    ..The three year KO1 award will provide the applicant with-additional research training and career skills that will greatly facilitate his transition to becoming a successful independent research investigator. ..